CN109662316A - A kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution and preparation method thereof - Google Patents
A kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution and preparation method thereof Download PDFInfo
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- CN109662316A CN109662316A CN201811597442.3A CN201811597442A CN109662316A CN 109662316 A CN109662316 A CN 109662316A CN 201811597442 A CN201811597442 A CN 201811597442A CN 109662316 A CN109662316 A CN 109662316A
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- cortex eucommiae
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Polymers & Plastics (AREA)
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- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solutions, oral solution is mixed and made by the material, auxiliary material and pure water of following ratio (mass ratio), wherein folium cortex eucommiae extract powder 4-6 parts, 2-4 parts of Extract of Huangqi, 1-3 parts of fructus lycii extract powder, 1-3 parts of huang jing extract powder, 1-2 parts of Chinese yam extract powder, 1-2 parts of Chinese date extract powder.The folium cortex eucommiae compound benefiting qi and nourishing blood oral solution prepared according to the present invention, have rebuild one's physical constitution, the health-care efficacies such as blood-nourishing bowl spares, be adapted to the demand of rehabilitation patient and sub-health population, wide market.
Description
Technical field
The invention belongs to health food manufacture field, it is related to a kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution and its preparation side
Method.
Background technique
Cortex Eucommiae is the distinctive rare tonic herb of China, and folium cortex eucommiae is rich in flavones, loose ester alcohol diglucoside, Geniposide
The various nutrient elements such as glycosides, chlorogenic acid, caffeic acid, aucubin, the minerals such as Yi Jitie, zinc, selenium, have clear liver and improve vision,
Tonify Qi of the kidney, regulating lipoid and reducing blood pressure, anti-inflammatory are antibacterial, strengthening the bones and muscles, anti-aging, it is antifatigue, increase many effects such as immunity.
More using folium cortex eucommiae as the functional beverage of core material at present, a variety of function of folium cortex eucommiae are often utilized in these
Effect, but it is a lack of the compound product for certain rehabilitation patients and sub-health population benefiting qi and nourishing blood.Furthermore it is soaked in folium cortex eucommiae
In the method mentioned, also the effective component of folium cortex eucommiae is not studied, to obtain the product of high nutritive value, it is ensured that product
Health-care efficacy.
Inventor is engaged in the research of Cortex Eucommiae beverage for many years, for example " a kind of Cortex Eucommiae is multiple in the Chinese patent of my invention in 2013
Close the preparation method (application No. is 201310658168.7) of anti-fatigue functional beverage, a kind of removal folium cortex eucommiae extract liquor peculiar smell is matched
The method (application No. is 201310658201.6) of health drink processed, a kind of preparation method of Cortex Eucommiae appetite-stimulating health-care drink
(201310658256.7) " in, a kind of preparation method of Cortex Eucommiae drinks is related to, after folium cortex eucommiae is extracted, using ozone
The method of processing and bioencapsulation processing overcomes careless fishy smell, bitter taste and the astringent taste problem outstanding in Cortex Eucommiae extract liquor, and soaks
Take use by folium cortex eucommiae boiled at 100 DEG C and hot conditions under the critical process that carries out.The above patented technology focuses on solving
The problem that folium cortex eucommiae peculiar smell how is removed in the preparation of Cortex Eucommiae beverage, does not optimize adjustment to technique in practice, to prevent
Only or reduce process for preparation in effective ingredient (active material) loss, so that it is guaranteed that the health-care efficacy of beverage.
Summary of the invention
The invention proposes a kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solutions and preparation method thereof, are with folium cortex eucommiae extract powder
Basic material, mixing are added to Radix Astragali, fructus lycii, rhizoma polygonati, Chinese yam, Chinese date extract powder, compound solid oral solution are made, is a kind of benefit
The health care product of gas blood-nourishing, after being ill rehabilitation, while link process optimization has been carried out in folium cortex eucommiae extraction, reduce effective component
It is lost, it is ensured that the health-care efficacy of oral solution.
The present invention is added to following auxiliary material on the basis of folium cortex eucommiae extract powder:
(1) Radix Astragali: based on qi-restoratives, be usually used in body decline with the passing of time, speech is low, thin and weak pulse person.There is enhancing immunity of organism
Function, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.
(2) fructus lycii: the immunity be capable of nourishing liver and kidney, benefiting shrewd head and blood-nourishing, enhance people, it is antifatigue and reduce blood pressure
And other effects.(3) rhizoma polygonati: there is the effect of boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.It is usually used in deficiency of spleen-QI and stomach-QI, fatigue and asthenia, stomach-Yin
Deficiency, dry deficiency of food, asthenia of essence and blood, soreness and weakness of waist and knees, the symptoms such as poliosis.(4) Chinese yam: there is qi-restoratives to nourish, tonifying middle-Jiao and Qi,
It gets rid of evils except cold, it is aid digestion, abnormal sweating is held back, the effect of antidiarrheal.(5) jujube: tonifying middle-Jiao and Qi, nourishing blood and tranquilization, beautifying face and moistering lotion and other effects.It will
Above-mentioned function raw material combines, and compound benefiting qi and nourishing blood oral solution is made.
Technical scheme is as follows:
A kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, it is mixed by the material, auxiliary material and pure water of following ratio (mass ratio)
Oral solution is made in conjunction, wherein folium cortex eucommiae extract powder 4-6 parts, 2-4 parts of Extract of Huangqi, and 1-3 parts of fructus lycii extract powder, huang jing extract powder
1-3 parts, 1-2 parts of Chinese yam extract powder, 1-2 parts of Chinese date extract powder.
In above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, auxiliary material be chitosan 4-6 parts, 2-4 parts of hydroxyl isomaltulose, β-ring
0.3-0.5 parts of dextrin, 0.3-0.5 parts of sodium carboxymethylcellulose, 0.1-0.15 parts of xanthan gum, 0.05-0.1 parts of potassium sorbate, lemon
0.05-0.1 parts of lemon acid, 0.075-0.15 parts of sodium citrate, 0.03-0.05 parts of calgon, ethylmaltol 0.01-0.02
Part；Pure water is 65-70 parts.
A kind of preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, which comprises the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
After the fresh folium cortex eucommiae of acquisition is dried in 60-70 DEG C of drying tunnel, ventilation is stored in using black woven bag and is kept away
It is spare in the warehouse of light；
[1.2] water logging is extracted
By the folium cortex eucommiae after cleaning according to dry folium cortex eucommiae: the ratio of water=1:10-30 (mass ratio) carries out flooding extraction,
Temperature is 60-70 DEG C, and water logging extraction time is 3-4 hours；
[1.3] filtering and concentrating
It is 20-30% (mass ratio) that leaching liquor, which is concentrated into solid content,；
[1.4] protective agent adds
Food acids are added in concentrated slurry, so that pH value is 3.5-4.0, add the table sugar of 5% (mass ratio), so
The beta-cyclodextrin of 5%-10% (mass ratio) is added afterwards, folium cortex eucommiae concentrate is made；
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, wherein shutting out
The moisture content of Zhong Ye extract powder is 5%-10%；It is stand-by that the folium cortex eucommiae extract powder of preparation is placed in low-temperature storage in sterile aluminum foil bag；
[2] prepared by oral solution:
By 4-6 parts of folium cortex eucommiae extract powder, 2-4 parts of Extract of Huangqi, 1-3 parts of fructus lycii extract powder, 1-3 parts of huang jing extract powder,
1-2 parts of Chinese yam extract powder, 1-2 parts of Chinese date extract powder, with after auxiliary material mixing, are added pure water 65-70 parts, at 60-70 DEG C of temperature
Feed liquid is made after being sufficiently stirred；Microwave disinfection is carried out after quantitative filling after filtering, homogeneous, wherein the material temperature in microwave disinfection
Degree control is at 60-70 DEG C.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, the moisture content of folium cortex eucommiae is low in step [1.1]
In 13%.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, the cleaning in step [1.2] is respectively adopted certainly
Water and pure water are sprayed wherein folium cortex eucommiae is placed on conveyer belt after being cleaned in pond with tap water with pure water
Cleaning.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, connected in step [1.2] using ultrasonic reverse back stream
Continuous extract equipment extracts.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, step sets folium cortex eucommiae leaching liquor in [1.3]
It is concentrated in dual-effect concentrator.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, food acids are citric acid, food in step [1.4]
It is sucrose or fructose with sugar.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, the outlet air of spray drying tower in step [1.5]
Temperature is 50-60 DEG C.
In the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, auxiliary material is chitosan 4-6 parts in step [2],
2-4 parts of hydroxyl isomaltulose, 0.3-0.5 parts of beta-cyclodextrin, 0.3-0.5 parts of sodium carboxymethylcellulose, 0.1-0.15 parts of xanthan gum, mountain
0.05-0.1 parts of potassium sorbate, 0.05-0.1 parts of citric acid, 0.075-0.15 parts of sodium citrate, 0.03-0.05 parts of calgon,
0.01-0.02 parts of ethylmaltol.
It is in step [2] that feed liquid is filling to vial in the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution
Or after plastic bottle, it is delivered to microwave sterilization machine and is sterilized, the frequency of microwave is 2450MHz.
It is in step [2] that feed liquid is filling to vial in the preparation method of above-mentioned folium cortex eucommiae compound benefiting qi and nourishing blood oral solution
Or after plastic bottle, it is delivered to microwave sterilization machine and is sterilized, the frequency of microwave is 2450MHz.
The advantageous effects that the present invention has are as follows:
1, the present invention for current rehabilitation patient and sub-health population insufficiency of vital energy and blood, it is weak and sickly the problems such as, preferred Du
Compound benefiting qi and nourishing blood oral solution is made in Zhong Ye, Radix Astragali, fructus lycii, rhizoma polygonati, Chinese yam, Chinese date extract powder, wherein Radix Astragali, fructus lycii, rhizoma polygonati,
Chinese yam, jujube are deployed by reasonable component ratio, play the role of blood-nourishing bowl spares, and Cortex Eucommiae is as rare invigorant, itself tool
Have the effect of regulating lipoid and reducing blood pressure, at the same also have it is neutral it is mild, as ministerial drug when the small property feature of repellency, can be with Radix Astragali, Chinese holly
The a variety of food medicinal material compatibilities of Qi, rhizoma polygonati, Chinese yam, jujube enhance effect.After oral solution is taken for a long time, except meeting current sub-healty adults
Group rebuilds one's physical constitution, outside the health care requirement of blood-nourishing bowl spares, moreover it is possible to play strengthening the bones and muscles, anti-aging, improve the composite efficacies such as immunity, entirely
Face nourishing is achieved many things at one stroke.
2, the present invention is in the stabilization to nutritional ingredients such as Chlorogenic Acid in Eucommia ulmoides Oliv. Leaves, flavones, Geniposidic acid, Aucubins
Property, on the basis of the characteristics such as anti-oxidant further investigation, in conjunction with the characteristic of institute's synthetic beverage, to the illumination influenced in raw material preparation,
The factors such as temperature, pH value have carried out accurate control, substantially increase product nutrient substances content.
3, intermediate products of the present invention in beverage --- in extract powder preparation, to the loss characteristic of folium cortex eucommiae nutritional ingredient into
Research of having gone, so that the PH that prime cement is concentrated is 3.5-4.0 or so, has by addition citric acid or the scheme of other food acid agent
Effect prevents the loss of the ingredients such as flavones, chlorogenic acid, Geniposidic acid, adjust again in beverage preparation in later use prime cement
To suitable pH value, the peculiar mouthfeel of Cortex Eucommiae beverage is maintained.The table sugar that joined 5% in concentration prime cement simultaneously, passes through increasing
Add sucrose concentration to reduce dissolved oxygen amount, effectively inhibits the oxygenolysis of the substances such as flavones, chlorogenic acid.Wherein selection 5% is sugared adds
Dosage be comprehensively consider sugared part ratio it is dry to subsequent spray to the degree of protection of nutritional ingredient and too low sugar in caused by
Agglomeration, viscous wall etc. influence, and carry out the result of parameter optimization.Furthermore it is added to the beta-cyclodextrin of 5%-10% before spray drying,
The characteristics of using its embedding effect and granular material, under the premise of not influencing drying process with atomizing, realize nutritional ingredient
Retain.
4, the raw material in the present invention takes shading treatment in storage and preparation process, and folium cortex eucommiae is stored up using black woven bag
It deposits, reducing illumination influences the brings oxygenolysis such as chlorogenic acid, Geniposidic acid, Aucubin；Simultaneously by picking
Fresh folium cortex eucommiae is processed in time is prepared into folium cortex eucommiae concentration prime cement or eucommia ulmoides extract product, and arranges through overnutrition protection
Long term storage is applied, and logistics deployment is carried out according to the progress demand of subsequent beverage preparation, is avoided in traditional Cortex Eucommiae beverage preparation
Because of the long term storage bring nutrient loss of folium cortex eucommiae, at the same also reduce storage area and strange land end product preparation plus
The transportation cost in working hour has adapted to the place of production in modern plants extraction product manufacturing and has carried out raw material roughing extraction, strange land completion eventually
Hold product manufacturing sale with the new model of save the cost.
5, the present invention has carried out accurate control to temperature in oral solution preparation, so that drying, water logging are extracted, concentration is dry
Temperature in dry controls within 70 DEG C, these measures effectively prevent the loss of effective component in folium cortex eucommiae.
6, the present invention prepares in oral solution and uses microwave sterilization in link instead of traditional TRANSIENT HIGH TEMPERATURE sterilization method, goes out
Pass through the temperature of monitoring oral solution during bacterium, and by extending sterilization time, temperature is controlled 60-70 DEG C, is gone out using microwave
The collective effect of microwave heating effect and non-thermal effect in bacterium becomes microbial body internal protein and physiological activity substance
Different, development delays and dead, achievees the purpose that food sterilizing, fresh-keeping, simultaneously because temperature control reduces often at 65 DEG C or so
Decomposition when advising high-temperature sterilization to flavones, chlorogenic acid, Geniposidic acid, aucubin and Pinoresinol diglucoside improves
The conservation rate of nutritional ingredient.Simultaneously in microwave sterilization, the product after packaging can be placed directly in microwave sterilization machine and be carried out,
Facilitate execute-in-place.
Specific embodiment
Inventor is studied for a long period of time discovery, either the storage of folium cortex eucommiae, water logging extract or beverage preparation link in,
The nutritional ingredients such as chlorogenic acid, flavones, Geniposidic acid, Aucubin, Pinoresinol diglucoside can all occur in various degree
It decomposes and is lost, major influence factors have:
(1) storage time and illumination effect
In traditional folium cortex eucommiae beverage processing, drying of being exposed to the sun in the sunlight after the picking of fresh folium cortex eucommiae, in the form of cured leaf into
Row long term storage carries out water logging extraction to Cortex Eucommiae leaf raw material again according to demand in beverage preparation.And inventor and other scholars
Research achievement show that raw material in prolonged storage, is influenced by extraneous factor, especially illumination is to yellow in folium cortex eucommiae
Ketone, chlorogenic acid, Geniposidic acid, Aucubin and Pinoresinol diglucoside have large effect effect, under light illumination
It easily causes oxygenolysis and causes nutrition loss.
For the influence of illumination factor in raw material long term storage, the present invention abandoned traditional folium cortex eucommiae drying and
Storing mode disposably dries storage using drying machine after feedstock capture in the fall, and carries out water to folium cortex eucommiae as early as possible
Extraction process is soaked, manufactured folium cortex eucommiae extract powder, which is placed in freezer, to be stored.In addition, taken in raw material storage and preparation process
Shading treatment, folium cortex eucommiae select the storage of black woven bag, and the folium cortex eucommiae concentration prime cement after preparation is then placed on the aluminium foil of shading
Bag stored for extended periods, this mode not only reduce the loss of nutritional ingredient, and by the side of folium cortex eucommiae at source long term storage
Formula is changed to the long term storage of folium cortex eucommiae extract powder, greatly reduce storage area and strange land beverage preparation processing when transport at
This.
(2) influence of temperature parameter
Traditional folium cortex eucommiae extracts usually leaches dozens of minutes in the boiled water boiled, and the newest result of study of inventor
During showing Cortex Eucommiae beverage preparation, high temperature is to flavones, chlorogenic acid, two grape of Geniposidic acid, Aucubin and rosin spirit
Glucoside has large effect, and chlorogenic acid therein is heat-sensitive substance, when heating temperature is more than 70 DEG C, green original in leaching liquid
The content meeting rapid decrease of acid, it is therefore desirable to water soaking temperature be controlled, the present invention is continuously extracted using ultrasonic reverse back stream and set
It is standby to be extracted in temperature for 60-70 DEG C, while taking into account extracting efficiency, reduce the loss of nutritional ingredient.
(3) influence of pH value and sugar
The research achievement of inventor shows the protection of sugar content and pH value appropriate in beverage to nutritional ingredient in folium cortex eucommiae
It acts on more significant.Within the scope of certain sucrose concentration, the loss late of the ingredients such as flavones, chlorogenic acid is with sucrose concentration in beverage
Increase and reduce, this is because the increase of sugared content, declines the oxygen content in solution, inhibits the oxidation of flavones, chlorogenic acid
It decomposes.Therefore concentration prime cement preparation in be purposefully added 5% sucrose, meet the requirement that extract powder product stores for a long time, and
The sugar of the ratio has no effect on subsequent spray drying process.In later period beverage preparation according to production need be diluted with water sugar it is dense
Degree, will not influence the mouthfeel of product.
By on pH value on nutritional ingredient influence studies have shown that for eucommia bark flavone, resist under acidic environment
Oxidability is stronger, and antioxidant activity significantly reduces under alkaline environment；And for chlorogenic acid, Geniposidic acid, peach jaurel
For glucoside and Pinoresinol diglucoside, under acidic environment, thermal stability is also at preferable states, comprehensively consider it is different at
Point different to the influence degree of pH value, and combine drink and production process and organoleptic requirements, final choice is by the soda acid of concentrate
Degree is 3.5-4.0 by increasing the scheme of the food acids such as citric acid to deploy to PH, realizes flavones and chlorogenic acid to the maximum extent
Etc. Different Nutritions ingredient balance retain.
(4) embedding effect of beta-cyclodextrin
Inventor it has been investigated that, a certain proportion of beta-cyclodextrin is added in folium cortex eucommiae concentrate, can effectively inhibit
The loss of the nutritional ingredients such as flavones and chlorogenic acid, this is because beta-cyclodextrin main component is stable oligosaccharide, embedding is made
With the oxygenolysis for inhibiting the nutritional ingredients such as chlorogenic acid, flavones, thermal stability is improved.And suitable beta-cyclodextrin will not be right
The mouthfeel of product has an impact, and will not also impact to the process that Cortex Eucommiae concentrate spray drying prepares extract powder.
Embodiment one:
The preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, comprising the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
The fresh folium cortex eucommiae for harvesting the current year 6-9 month is placed in circulation drying tunnel and is dried at 60 DEG C, so that folium cortex eucommiae contains
Water rate is lower than 13%, and cured leaf is stored in spare in the warehouse of ventilation lucifugal using black woven bag；
[1.2] water logging is extracted
Folium cortex eucommiae to be cleaned, cleaning is divided into two steps: folium cortex eucommiae is placed in pond and is cleaned using tap water by the first step,
Wash off the dust on blade face；Folium cortex eucommiae after cleaning is placed on conveyer belt by second step, is dripped after carrying out spray cleaning using pure water
It is dry；
By the folium cortex eucommiae after cleaning according to dry Cortex Eucommiae leaf raw material: the ratio of water=1:10 (mass ratio) is placed in ultrasonic reverse back
It flows continuous extract equipment to extract, temperature is 60 DEG C, and water logging extraction time is 3 hours；The work of the ultrasonic continuous extract equipment of reverse back stream
It is that the high-frequency signal issued by ultrasonic wave is converted into the cell that mechanical oscillating wave destroys extract by energy converter as principle
Wall dissolves in effective component with free state and completes extraction process in water, and ensures that the effective component of water and extract is quickly melted
Dissolution is closed, while effective component is not destroyed, extraction time and efficiency are significantly improved.The equipment can be automatic at low temperature real
Existing continuous feed and continuous discharge, have the characteristics that water-saving, energy conservation, recovery rate are high.
[1.3] filtering and concentrating
Leaching liquor is placed in inspissator and is concentrated, being concentrated into solid content is 20% or so.Inspissator is preferably double
Inspissator is imitated, which can be had using external heat Natural Circulation and negative pressure of vacuum mode according to enrichment factor come selection parameter
The features such as evaporation rate is fast, and cocnentration factor is great, pollution-free, easy to clean.
[1.4] protective agent adds
Citric acid, uniform and monitoring potential stirring while adding, until pH value is 3.5 are added in concentrated slurry；
Sucrose is added according still further to the ratio of 5% (mass ratio), the beta-cyclodextrin of 10% (mass ratio) is then added, folium cortex eucommiae concentration is made
Liquid；
The purpose that food acids, table sugar and beta-cyclodextrin is added is to prevent the oxygen of nutritional ingredient in folium cortex eucommiae in concentrate
Change loss, extends shelf lives, and have no effect on subsequent drink mouthfeel.
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, control into
Air temperature is 100 DEG C, and leaving air temp is 50 DEG C, and the moisture content for the folium cortex eucommiae extract powder being prepared is 5%-10%；
Material enters the hot wind progress that drying tower is atomization, sends with air inlet fan in dryer section through centrifugal spraying disk in implementation
Heat exchange, surface of material moisture evaporate rapidly, are landed the cone below equipment by dry extract powder, humid air is by arranging in tower
Blower is discharged, and institute's band particle is down in cone through Bag filter recycling and is mixed with extract powder in exhaust gas, automatic through rotating blanking valve
It flows out in tower.
[1.6] it stores
Manufactured folium cortex eucommiae extract powder is canned into sterile aluminum foil bag in clean workplace, and in air-conditioned cold store or freezer
It is stored, is prepared for beverage and other products, wherein the storage temperature of freezer is -10~-5 DEG C.
[2] mother liquor
By 4 parts of folium cortex eucommiae extract powder, 2 parts of Extract of Huangqi, 1 part of fructus lycii extract powder, 1 part of huang jing extract powder, Chinese yam medicinal extract
1 part of powder, 1 part of Chinese date extract powder, 4 parts of chitosan, 2 parts of hydroxyl isomaltulose, 0.3 part of beta-cyclodextrin, sodium carboxymethylcellulose 0.3
Part, 0.1 part of xanthan gum, 0.05 part of potassium sorbate, 0.05 part of citric acid, 0.075 part of sodium citrate, 0.03 part of calgon,
0.01 part of ethylmaltol, 65 parts of pure water are added, feed liquid is made after being sufficiently stirred under temperature 60 C；
[3] filtering, homogeneous, sterilizing, filling
Mother liquor after ingredient is pumped into high pressure homogenizer after the filtering of diatomite plate filter and carries out homogeneous, after homogeneous
After the filling vial or plastic bottle to 10 milliliters of drink, it is delivered to microwave sterilization machine and is sterilized；Wherein diatomite sheet frame mistake
The filtering accuracy of filter is 400 mesh, and the homogenization pressure of high pressure homogenizer is 60kPa；The frequency of microwave is 2450MHz in sterilizing,
The temperature of material is controlled at 60 DEG C in sterilization process, and the time of sterilizing depending on drink flow and microwave power, drinks after sterilizing
The total plate count and yeast bacterial content of product are no more than national regulations.
[4] it is packed and stored
Vanning, coding, inspection, storage.
Embodiment two:
The preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, comprising the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
The fresh folium cortex eucommiae for harvesting the current year 6-9 month is placed in circulation drying tunnel and is dried at 70 DEG C, so that folium cortex eucommiae contains
Water rate is lower than 13%, and cured leaf is stored in spare in the warehouse of ventilation lucifugal using black woven bag；
[1.2] water logging is extracted
Folium cortex eucommiae to be cleaned, cleaning is divided into two steps: folium cortex eucommiae is placed in pond and is cleaned using tap water by the first step,
Wash off the dust on blade face；Folium cortex eucommiae after cleaning is placed on conveyer belt by second step, is dripped after carrying out spray cleaning using pure water
It is dry；
By the folium cortex eucommiae after cleaning according to dry Cortex Eucommiae leaf raw material: the ratio of water=1:30 (mass ratio) is placed in ultrasonic reverse back
It flows continuous extract equipment to extract, temperature is 70 DEG C, and water logging extraction time is 4 hours；The work of the ultrasonic continuous extract equipment of reverse back stream
It is that the high-frequency signal issued by ultrasonic wave is converted into the cell that mechanical oscillating wave destroys extract by energy converter as principle
Wall dissolves in effective component with free state and completes extraction process in water, and ensures that the effective component of water and extract is quickly melted
Dissolution is closed, while effective component is not destroyed, extraction time and efficiency are significantly improved.The equipment can be automatic at low temperature real
Existing continuous feed and continuous discharge, have the characteristics that water-saving, energy conservation, recovery rate are high.
[1.3] filtering and concentrating
Leaching liquor is placed in inspissator and is concentrated, being concentrated into solid content is 30% or so.Inspissator is preferably double
Inspissator is imitated, which can be had using external heat Natural Circulation and negative pressure of vacuum mode according to enrichment factor come selection parameter
The features such as evaporation rate is fast, and cocnentration factor is great, pollution-free, easy to clean.
[1.4] protective agent adds
Citric acid, uniform and monitoring potential stirring while adding, until pH value is 4.0 are added in concentrated slurry；
Sucrose is added according still further to the ratio of 5% (mass ratio), the beta-cyclodextrin of 5% (mass ratio) is then added, folium cortex eucommiae concentration is made
Liquid；
The purpose that food acids, table sugar and beta-cyclodextrin is added is to prevent the oxygen of nutritional ingredient in folium cortex eucommiae in concentrate
Change loss, extend shelf lives, and since concentrate and extract powder are beverage and the intermediate product of other product configurations, and simultaneously
Subsequent drink mouthfeel is not influenced.
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, control into
Air temperature is 120 DEG C, and leaving air temp is 60 DEG C, and the moisture content for the folium cortex eucommiae extract powder being prepared is 5%-10%；
[1.6] it stores
Manufactured folium cortex eucommiae extract powder is canned into sterile aluminum foil bag in clean workplace, and in air-conditioned cold store or freezer
It is stored, is prepared for beverage and other products, wherein the storage temperature of freezer is -10~-5 DEG C.
[2] mother liquor
By 4 parts of 6 parts of folium cortex eucommiae extract powder, the Extract of Huangqi of storage, 3 parts of fructus lycii extract powder, 3 parts of huang jing extract powder, mountain
2 parts of medicine extract powder, 2 parts of Chinese date extract powder, 6 parts of chitosan, 4 parts of hydroxyl isomaltulose, 0.5 part of beta-cyclodextrin, carboxymethyl cellulose
0.5 part of sodium, 0.15 part of xanthan gum, 0.1 part of potassium sorbate, 0.1 part of citric acid, 0.15 part of sodium citrate, calgon 0.05
Part, 0.02 part of ethylmaltol, 70 parts of pure water are added, feed liquid is made after being sufficiently stirred under temperature 70 C；
[3] filtering, homogeneous, sterilizing, filling
Mother liquor after ingredient is pumped into high pressure homogenizer after the filtering of diatomite plate filter and carries out homogeneous, after homogeneous
After the filling vial or plastic bottle to 10 milliliters of drink, it is delivered to microwave sterilization machine and is sterilized；Wherein diatomite sheet frame mistake
The filtering accuracy of filter is 400 mesh, and the homogenization pressure of high pressure homogenizer is 60kPa；The frequency of microwave is 2450MHz in sterilizing,
The temperature of material is controlled at 70 DEG C in sterilization process, and the time of sterilizing depending on drink flow and microwave power, drinks after sterilizing
The total plate count and yeast bacterial content of product are no more than national regulations.
[4] it is packed and stored
Vanning, coding, inspection, storage.
In order to be verified to above-mentioned technical effect, the present invention carried out respectively folium cortex eucommiae drying sunning comparative experiments,
Extraction temperature comparative experiments, pH value comparative experiments, pol comparative experiments, beta-cyclodextrin embedding experiment, and chromatographic column is used, according to
National standard measurement method determines the content of the nutritional ingredients such as flavones, chlorogenic acid, Pinoresinol diglucoside.Experimental result
It is as follows:
(1) drying sunning comparative experiments
The fresh folium cortex eucommiae of picking is divided into three parts of phase homogenous quantities, carried out respectively fresh leaf directly extract, the sun
Under dry with the drying experiment of 60-70 DEG C of machine, wherein dried under the sun and continue one week under ventilated environment in the fall, use is identical
Process conditions are completed water logging and are extracted.Every group is tested in triplicate, takes its average value, measures the relative amount of its nutritional ingredient.Knot
Fruit is as shown in table 1.
The drying sunning control experiment result of table 1
1 experimental data of table explanation, using 60-70 DEG C of machine drying technology, than being dried under traditional sun to flavones and green
10% or so reserved can be improved in ortho acid.
(2) extraction temperature control experiment
The Folium Eucommiae of equal mass is placed in water logging in extractor to extract, only changes water soaking temperature, other parameters are identical,
Setting at a temperature of heat 30 minutes, then kept for 3 hours at 60 DEG C, measure the relative amount of its nutritional ingredient.Every group
It tests in triplicate, takes its average value, the results are shown in Table 2.
2 extraction temperature control experiment of table
| Extraction temperature | 100℃ | 90℃ | 80℃ | 70℃ | 60℃ | 50℃ |
| Chlorogenic acid | 75.2% | 80.4% | 88.5% | 96.8% | 105.3% | 100% |
| Pinoresinol diglucoside | 73.3% | 79.1% | 85.5% | 92.2% | 98.2% | 100% |
2 experimental data of table explanation, extraction temperature are most important to the reservation of nutritional ingredient.
(3) pH value control experiment
Appropriate citric acid is added in leaching liquor, is adjusted pH to setting value, is kept in dark place 3 months at room temperature, measures its battalion
The relative amount formed point, every group is tested in triplicate, takes its average value, the results are shown in Table 3.
Table 3PH value control experiment
| PH value | 3.0 | 4.0 | 5.0 | 6.0 |
| Chlorogenic acid | 110.3% | 104.6% | 103.5% | 100% |
| Flavones | 114.3% | 109.1% | 102.8% | 100% |
3 experimental data of table explanation, leaching liquor is under acidic environment, conducive to the long-term preservation of nutriment.
(4) pol control experiment
Suitable amount of sucrose is added in leaching liquor, is adjusted sugar content, is kept in dark place 3 months at room temperature, measures its nutritional ingredient
Relative amount, every group is tested in triplicate, takes its average value, the results are shown in Table 4.
4 pol control experiment of table
| Sugar content | 0% | 5% | 10% | 15% | 20% | 25% | 30% |
| Chlorogenic acid | 83.4% | 92.0% | 94.6% | 97.1% | 97.2% | 97.9% | 100% |
| Flavones | 84.3% | 91.9% | 95.2% | 96.5% | 97.2% | 98.0% | 100% |
4 experimental data of table explanation, addition sucrose facilitate the long-term preservation of leaching liquor nutriment.
(5) beta-cyclodextrin embedding experiment
Suitable beta-cyclodextrin is added in leaching liquor, is adjusted adding proportion, is kept in dark place 3 months at room temperature, measures it
The relative amount of nutritional ingredient, every group is tested in triplicate, takes its average value, the results are shown in Table 5.
The embedding experiment of 5 beta-cyclodextrin of table
| Beta-cyclodextrin amount | 0% | 2% | 4% | 6% | 8% | 10% |
| Chlorogenic acid | 88.2% | 90.4% | 90.4% | 93.0% | 94.6% | 100% |
| Pinoresinol diglucoside | 90.2% | 93.6% | 93.0% | 95.6% | 97.8% | 100% |
5 experimental data of table explanation is added beta-cyclodextrin to folium cortex eucommiae leaching liquor, facilitates the long-term preservation of nutriment.
The present invention on influenced in beverage and other product configurations the temperature of folium cortex eucommiae nutritional ingredient, illumination, pH value, containing sugar
Amount etc. has carried out parameter optimization and accurate control, is used successfully in the preparation of extract powder, and further experiment shows this hair
It is bright that the retention rate of the nutritional ingredients such as flavones, chlorogenic acid improves 20%-30% compared with traditional folium cortex eucommiae extractive technique,
Effectively reduce the loss of nutritional ingredient in product, it is ensured that the health-care efficacy of Cortex Eucommiae leaf beverage.
The folium cortex eucommiae compound benefiting qi and nourishing blood oral solution prepared according to the present invention, color is reddish brown bright, does not precipitate significantly,
And have the weak coffee fragrance of Cortex Eucommiae, have rebuild one's physical constitution, the health-care efficacies such as blood-nourishing bowl spares, be adapted to rehabilitation patient and sub-healty adults
The demand of group, wide market.
Claims (11)
1. a kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, it is characterised in that: by the material of following ratio (mass ratio), auxiliary material and
Pure water is mixed and made into oral solution, wherein folium cortex eucommiae extract powder 4-6 parts, 2-4 parts of Extract of Huangqi, 1-3 parts of fructus lycii extract powder, yellow
Smart extract powder 1-3 parts, 1-2 parts of Chinese yam extract powder, 1-2 parts of Chinese date extract powder.
2. a kind of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 1, it is characterised in that: auxiliary material is chitosan
4-6 parts, 2-4 parts of hydroxyl isomaltulose, 0.3-0.5 parts of beta-cyclodextrin, 0.3-0.5 parts of sodium carboxymethylcellulose, xanthan gum 0.1-
0.15 part, 0.05-0.1 parts of potassium sorbate, 0.05-0.1 parts of citric acid, 0.075-0.15 parts of sodium citrate, calgon
0.03-0.05 parts, 0.01-0.02 parts of ethylmaltol；Pure water is 65-70 parts.
3. a kind of preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution, which comprises the following steps:
[1] preparation of folium cortex eucommiae extract powder:
[1.1] feedstock capture
After the fresh folium cortex eucommiae of acquisition is dried in 60-70 DEG C of drying tunnel, ventilation lucifugal is stored in using black woven bag
It is spare in warehouse；
[1.2] water logging is extracted
By the folium cortex eucommiae after cleaning according to dry folium cortex eucommiae: the ratio of water=1:10-30 (mass ratio) carries out flooding extraction, temperature
It is 60-70 DEG C, water logging extraction time is 3-4 hours；
[1.3] filtering and concentrating
It is 20-30% (mass ratio) that leaching liquor, which is concentrated into solid content,；
[1.4] protective agent adds
Food acids are added in concentrated slurry so that pH value be 3.5-4.0, add the table sugar of 5% (mass ratio), then plus
Folium cortex eucommiae concentrate is made in the beta-cyclodextrin for entering 5%-10% (mass ratio)；
[1.5] it is spray-dried
Cortex Eucommiae concentrate is placed in spray drying tower and is spray-dried, folium cortex eucommiae extract powder is prepared, wherein folium cortex eucommiae
The moisture content of extract powder is 5%-10%；It is stand-by that the folium cortex eucommiae extract powder of preparation is placed in low-temperature storage in sterile aluminum foil bag；
[2] prepared by oral solution:
By 4-6 parts of folium cortex eucommiae extract powder, 2-4 parts of Extract of Huangqi, 1-3 parts of fructus lycii extract powder, 1-3 parts of huang jing extract powder, Chinese yam
1-2 parts of extract powder, 1-2 parts of Chinese date extract powder, with after auxiliary material mixing, are added pure water 65-70 parts, fill at 60-70 DEG C of temperature
Feed liquid is made after dividing stirring；Microwave disinfection is carried out after quantitative filling after filtering, homogeneous, wherein the temperature of charge in microwave disinfection
Control is at 60-70 DEG C.
4. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.1] moisture content of folium cortex eucommiae is lower than 13% in.
5. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.2] tap water and pure water is respectively adopted in the cleaning in, wherein folium cortex eucommiae is placed in biography after being cleaned in pond with tap water
It send and takes, carry out spray with pure water and clean.
6. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.2] it is extracted in using the ultrasonic continuous extract equipment of reverse back stream.
7. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.3] folium cortex eucommiae leaching liquor is placed in dual-effect concentrator in and is concentrated.
8. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.4] food acids are citric acid in, and table sugar is sucrose or fructose.
9. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[1.5] leaving air temp of spray drying tower is 50-60 DEG C in.
10. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[2] in auxiliary material be chitosan 4-6 parts, 2-4 parts of hydroxyl isomaltulose, 0.3-0.5 parts of beta-cyclodextrin, sodium carboxymethylcellulose 0.3-
0.5 part, 0.1-0.15 parts of xanthan gum, 0.05-0.1 parts of potassium sorbate, 0.05-0.1 parts of citric acid, sodium citrate 0.075-0.15
Part, 0.03-0.05 parts of calgon, 0.01-0.02 parts of ethylmaltol.
11. the preparation method of folium cortex eucommiae compound benefiting qi and nourishing blood oral solution according to claim 3, it is characterised in that: step
[2] in that feed liquid is filling to after vial or plastic bottle, it is delivered to microwave sterilization machine and is sterilized, the frequency of microwave is
2450MHz。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115363204A (en) * | 2022-08-31 | 2022-11-22 | 蔡福带 | Oral liquid for tonifying qi and blood and helping sleep and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988527A (en) * | 2012-11-19 | 2013-03-27 | 董德华 | Pharmaceutical composition for treating anaemia |
-
2018
- 2018-12-26 CN CN201811597442.3A patent/CN109662316A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988527A (en) * | 2012-11-19 | 2013-03-27 | 董德华 | Pharmaceutical composition for treating anaemia |
Non-Patent Citations (4)
| Title |
|---|
| 叶文峰: "杜仲叶、大蒜复合饮料的研制", 《食品科学》 * |
| 戚向阳等: "杜仲保健饮料中活性成分的稳定性研究", 《食品工业科技》 * |
| 肖玫等: "模糊数学评判杜仲叶复合保健饮料的生产配方", 《食品科学》 * |
| 蔡向红: "《单味中药补养速查》", 31 March 2017, 安徽科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115363204A (en) * | 2022-08-31 | 2022-11-22 | 蔡福带 | Oral liquid for tonifying qi and blood and helping sleep and preparation method thereof |
| CN115363204B (en) * | 2022-08-31 | 2023-11-17 | 蔡福带 | Qi-invigorating and blood-helping sleep-aiding oral liquid and preparation method thereof |
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