CN109715658B - 可溶性成纤维细胞生长因子受体3(sfgfr3)多肽及其用途 - Google Patents

可溶性成纤维细胞生长因子受体3(sfgfr3)多肽及其用途 Download PDF

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Publication number
CN109715658B
CN109715658B CN201780049433.8A CN201780049433A CN109715658B CN 109715658 B CN109715658 B CN 109715658B CN 201780049433 A CN201780049433 A CN 201780049433A CN 109715658 B CN109715658 B CN 109715658B
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sfgfr3
seq
polypeptide
del4
amino acid
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Expired - Fee Related
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Chinese (zh)
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CN109715658A (zh
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埃尔维雷·古兹
斯特凡妮·加西亚
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Blue Coast University
French Institute Of Health And Medicine
Tera Sean Holdings Ltd
Therachon
Pfizer Corp SRL
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Blue Coast University
French Institute Of Health And Medicine
Therachon
Universite de Nice Sophia Antipolis UNSA
Pfizer Corp SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
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  • Cell Biology (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201780049433.8A 2016-07-07 2017-07-07 可溶性成纤维细胞生长因子受体3(sfgfr3)多肽及其用途 Expired - Fee Related CN109715658B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662359607P 2016-07-07 2016-07-07
US62/359,607 2016-07-07
US201762467478P 2017-03-06 2017-03-06
US62/467,478 2017-03-06
PCT/EP2017/067119 WO2018007597A1 (en) 2016-07-07 2017-07-07 Soluble fibroblast growth factor receptor 3 (sfgfr3) polypeptides and uses thereof

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CN109715658A CN109715658A (zh) 2019-05-03
CN109715658B true CN109715658B (zh) 2023-09-12

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RU2751483C2 (ru) 2016-07-07 2021-07-14 Пфайзер Инк. Полипептиды, являющиеся растворимыми рецепторами 3 фактора роста фибробластов (sfgfr3), и пути их применения
CA3076396A1 (en) * 2017-09-20 2019-03-28 Pfizer Inc. Treatment of abnormal visceral fat deposition using soluble fibroblast growth factor receptor 3 (sfgfr3) polypeptides
WO2020243478A1 (en) * 2019-05-29 2020-12-03 Massachusetts Eye And Ear Infirmary Fibroblast growth factor 2 (fgf2) for treatment of human sensorineural hearing loss
US11625937B2 (en) * 2020-04-06 2023-04-11 Toyota Motor Engineering & Manufacturing North America, Inc. Methods and systems for monitoring human body weight with vehicle sensors and big data AI analytics
WO2022106976A1 (en) 2020-11-18 2022-05-27 Pfizer Inc. Stable pharmaceutical formulations of soluble fgfr3 decoys
WO2022254319A1 (en) 2021-06-01 2022-12-08 Pfizer Inc. Cell culture method for producing sfgfr3 polypeptide
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
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CN116284327A (zh) * 2023-03-28 2023-06-23 中国药科大学 一种靶向肿瘤的成纤维细胞生长因子19的重组蛋白及其应用

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SI3481859T1 (sl) 2022-07-29
BR112019000257A2 (pt) 2019-10-01
WO2018007597A1 (en) 2018-01-11
CA3029877A1 (en) 2018-01-11
US20200190162A1 (en) 2020-06-18
RU2019100381A (ru) 2020-08-11
CA3029877C (en) 2023-07-25
KR20190037240A (ko) 2019-04-05
ZA201900507B (en) 2023-04-26
US10294289B2 (en) 2019-05-21
EP3481859A1 (en) 2019-05-15
JP2019527053A (ja) 2019-09-26
US20180230197A1 (en) 2018-08-16
AU2017294551A1 (en) 2019-01-31
US20210309718A1 (en) 2021-10-07
PL3481859T3 (pl) 2022-07-11
KR20220122762A (ko) 2022-09-02
SG11201900074WA (en) 2019-02-27
EP3481859B1 (en) 2022-04-13
KR102432192B1 (ko) 2022-08-12
MX2018016257A (es) 2019-11-21
RU2751483C2 (ru) 2021-07-14
EP4122955A1 (en) 2023-01-25
IL264030A (en) 2019-01-31
JP7348980B2 (ja) 2023-09-21
RU2019100381A3 (enExample) 2020-11-23
ES2912559T3 (es) 2022-05-26
US11021528B2 (en) 2021-06-01
AU2017294551B2 (en) 2022-03-03
PT3481859T (pt) 2022-05-23
US11697678B2 (en) 2023-07-11
JP2022096660A (ja) 2022-06-29
AU2022202906A1 (en) 2022-05-26
CN109715658A (zh) 2019-05-03
DK3481859T3 (da) 2022-04-25
HUE058734T2 (hu) 2022-09-28
JP7046903B2 (ja) 2022-04-04

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