CN109715620B - 作为alk抑制剂的氨基嘧啶 - Google Patents

作为alk抑制剂的氨基嘧啶 Download PDF

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Publication number
CN109715620B
CN109715620B CN201780057518.0A CN201780057518A CN109715620B CN 109715620 B CN109715620 B CN 109715620B CN 201780057518 A CN201780057518 A CN 201780057518A CN 109715620 B CN109715620 B CN 109715620B
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compound
pharmaceutically acceptable
acceptable salt
cancer
compounds
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Chinese (zh)
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CN109715620A (zh
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王少萌
陈建勇
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University of Michigan Ann Arbor
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University of Michigan Ann Arbor
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Priority to CN202210533398.XA priority Critical patent/CN115043821B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780057518.0A 2016-08-29 2017-08-28 作为alk抑制剂的氨基嘧啶 Active CN109715620B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210533398.XA CN115043821B (zh) 2016-08-29 2017-08-28 作为alk抑制剂的氨基嘧啶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662380818P 2016-08-29 2016-08-29
US62/380,818 2016-08-29
PCT/US2017/048845 WO2018044767A2 (en) 2016-08-29 2017-08-28 Aminopyrimidines as alk inhibitors

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CN202210533398.XA Division CN115043821B (zh) 2016-08-29 2017-08-28 作为alk抑制剂的氨基嘧啶

Publications (2)

Publication Number Publication Date
CN109715620A CN109715620A (zh) 2019-05-03
CN109715620B true CN109715620B (zh) 2022-05-06

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CN201780057518.0A Active CN109715620B (zh) 2016-08-29 2017-08-28 作为alk抑制剂的氨基嘧啶
CN202210533398.XA Active CN115043821B (zh) 2016-08-29 2017-08-28 作为alk抑制剂的氨基嘧啶

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US (2) US10709705B2 (enExample)
EP (2) EP3504203B1 (enExample)
JP (2) JP7094566B2 (enExample)
KR (1) KR102530871B1 (enExample)
CN (2) CN109715620B (enExample)
AU (2) AU2017319135B2 (enExample)
IL (1) IL264638B (enExample)
MX (2) MX389265B (enExample)
NZ (1) NZ751713A (enExample)
SG (2) SG11201901251SA (enExample)
WO (1) WO2018044767A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019314625B2 (en) * 2018-07-31 2022-05-12 Ascentage Pharma (Suzhou) Co., Ltd. Method for treating cancer by combination of FAK/ALK/ROS1 inhibitor and EGFR inhibitor
CN111171033B (zh) * 2018-11-09 2021-11-02 天津大学 一种嘧啶衍生物及其合成方法和应用
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN110143947B (zh) * 2019-05-29 2021-10-15 华东师范大学 一种色瑞替尼类似物的制备方法
US20220117964A1 (en) * 2019-06-25 2022-04-21 Ascentage Pharma (Suzhu) Co., Ltd. Combination of fak inhibitor and btk inhibitor for treating a disease
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230381176A1 (en) * 2020-09-25 2023-11-30 Ascentage Pharma (Suzhou) Co., Ltd. A pharmaceutical composition and use thereof for treatment of cancer
CN115212311B (zh) * 2021-04-19 2024-08-09 苏州亚盛药业有限公司 一种药物组合及其用途
AU2022404890A1 (en) * 2021-12-09 2024-06-06 Oncobix Co., Ltd. Novel heterocyclic-substituted pyrimidine derivative exhibiting cancer cell growth inhibitory effect, and pharmaceutical composition containing same
CN116332919B (zh) * 2022-03-30 2025-08-26 苏州亚盛药业有限公司 一种alk抑制剂化合物及其中间体的制备方法
TWI885708B (zh) * 2023-01-20 2025-06-01 大陸商蘇州亞盛藥業有限公司 Alk抑制劑或其鹽、溶劑合物的結晶形式及其製備方法和應用
WO2024193693A1 (zh) * 2023-03-22 2024-09-26 苏州亚盛药业有限公司 药物组合及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1852900A (zh) * 2003-09-18 2006-10-25 诺瓦提斯公司 可用于治疗增殖性病症的2,4－二(苯基氨基)嘧啶类
CN101921236A (zh) * 2003-03-14 2010-12-22 诺瓦提斯公司 可用于治疗赘生性疾病、炎性和免疫系统病症的2,4-二(苯氨基)嘧啶
WO2012106540A1 (en) * 2011-02-02 2012-08-09 Irm Llc Methods of using alk inhibitors
WO2015081813A1 (zh) * 2013-12-03 2015-06-11 上海翰森生物医药科技有限公司 具有alk抑制活性的化合物及其制备与用途
WO2015130014A1 (ko) * 2014-02-28 2015-09-03 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
PL2287156T3 (pl) 2003-08-15 2013-11-29 Novartis Ag 2,4-Di(fenyloamino)-pirymidyny stosowane w leczeniu chorób nowotworowych, chorób zapalnych i zaburzeń układu immunologicznego
ME02125B (me) * 2004-04-07 2013-04-30 Novartis Ag Inhibitori protein apoptoze (iap)
CN101616895A (zh) 2006-12-08 2009-12-30 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
CA2720946C (en) 2008-04-07 2013-05-28 Irm Llc Compounds and compositions as protein kinase inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
JP2013539795A (ja) 2010-10-14 2013-10-28 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖の阻害方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101921236A (zh) * 2003-03-14 2010-12-22 诺瓦提斯公司 可用于治疗赘生性疾病、炎性和免疫系统病症的2,4-二(苯氨基)嘧啶
CN1852900A (zh) * 2003-09-18 2006-10-25 诺瓦提斯公司 可用于治疗增殖性病症的2,4－二(苯基氨基)嘧啶类
WO2012106540A1 (en) * 2011-02-02 2012-08-09 Irm Llc Methods of using alk inhibitors
WO2015081813A1 (zh) * 2013-12-03 2015-06-11 上海翰森生物医药科技有限公司 具有alk抑制活性的化合物及其制备与用途
WO2015130014A1 (ko) * 2014-02-28 2015-09-03 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물

Also Published As

Publication number Publication date
EP3504203A2 (en) 2019-07-03
MX2019002393A (es) 2019-07-08
JP2022120151A (ja) 2022-08-17
CN115043821B (zh) 2024-08-06
AU2021203098A1 (en) 2021-06-10
SG10201914030UA (en) 2020-03-30
US20190175595A1 (en) 2019-06-13
CA3033223A1 (en) 2018-03-08
BR112019003897A2 (pt) 2019-05-21
AU2017319135B2 (en) 2021-03-18
SG11201901251SA (en) 2019-03-28
MX389265B (es) 2025-03-20
US11110090B2 (en) 2021-09-07
IL264638B (en) 2021-08-31
KR102530871B1 (ko) 2023-05-09
CN109715620A (zh) 2019-05-03
AU2017319135A1 (en) 2019-04-04
JP2019528307A (ja) 2019-10-10
MX2022000376A (es) 2022-02-10
KR20190039760A (ko) 2019-04-15
US10709705B2 (en) 2020-07-14
US20200330464A1 (en) 2020-10-22
EP4001273A2 (en) 2022-05-25
CN115043821A (zh) 2022-09-13
WO2018044767A3 (en) 2018-04-12
NZ751713A (en) 2022-07-01
AU2021203098B2 (en) 2023-05-25
JP7094566B2 (ja) 2022-07-04
EP3504203B1 (en) 2022-09-28
WO2018044767A2 (en) 2018-03-08
EP4001273A3 (en) 2022-08-24

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