CN109662999A - A kind of pulvis and preparation method thereof for treating diabetic foot ulcer - Google Patents
A kind of pulvis and preparation method thereof for treating diabetic foot ulcer Download PDFInfo
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- CN109662999A CN109662999A CN201810711490.4A CN201810711490A CN109662999A CN 109662999 A CN109662999 A CN 109662999A CN 201810711490 A CN201810711490 A CN 201810711490A CN 109662999 A CN109662999 A CN 109662999A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
A kind of pulvis for treating sugar material foot disease ulcer, it is characterized in that, it is made of the raw material of following parts by weight: 65-80 parts of bioactivity silicon, 10-25 parts of calamine stone, 5-8 parts of charred RADIX RUBIAE, 1-3 parts of vitamin c powder, this formula uses specific proportion, using bioactivity silicon as major ingredient, cooperate calamine, charred RADIX RUBIAE, the auxiliary elements such as vitamin c powder mix, over the course for the treatment of can be antibacterial well and absorb the secretion of ulcer spot, improve local wound microenvironment, promote the wound healing of diabetic foot ulcer, realize the reconstruction of sugar material foot disease ulcer spot blood vessel, and energy dissolving stasis after the completion of healing, it promotes blood circulation, fundamentally solve the problems, such as diabetic foot ulcer.
Description
Technical field
The present invention relates to the technical field of external drug pulvis more particularly to a kind of pulvis for treating diabetic foot ulcer and
Preparation method.
Background technique
Diabetes refer to that diabetic foot makes the decline of lower limb defencive function, big blood vessel and micro- blood due to neuropathy
Pipe lesion makes arterial perfusion deficiency cause microcirculation disorder and ulcer and gangrenous morbid state occurs.Diabetes are diabetes one
Kind serious complication is that diabetic is disabled or even lethal one of the major reasons, not only causes suffering to patient, and
And it is made to add huge financial burden.
It include: at present general debridement treatment, reconstructive vascular operation, externally applied drug promotion healing for the treatment of diabetes
Deng；But diabetic foot ulcer difference and other ulcer, ulcer can also be spread after the tissue of necrosis is removed using traditional debridement, instead
Amputation can only finally be moved towards by dispelling again, bring great pain to patient；Reconstructing blood vessel relies primarily on minimally invasive and traditional bridging
Art combines, but success rate is not high and patient vessel can block again again shortly after dredging, and operation is to trouble repeatedly
Person brings pain and economic pressures；Although traditional external drug can promote Wound healing, but still not can solve reconstructing blood vessel
Problem cannot still prevent further ulcer repeatedly.
Summary of the invention
The present invention provides a kind of pulvis and preparation method thereof for treating diabetic foot ulcer, it is therefore an objective to solve the prior art and ask
Topic, blood vessel is rebuild in dredging while providing a kind of promotion ulcer Wound healing, fundamentally to solve the treatment sugar of patient suffering
Urinate the method for the pulvis and its preparation of foot disease ulcer.
The present invention solve the problems, such as the technical solution adopted is that:
A kind of pulvis for treating diabetic foot ulcer, which is characterized in that be made of the raw material of following parts by weight: bioactivity silicon
65-80 parts, 10-25 parts of calamine stone, 5-8 parts of charred RADIX RUBIAE, 1-3 parts of vitamin c powder.
The ingredient of the bioactivity silicon are as follows: without fixed kenel silica 50-75%, phosphorous oxides 8-15%, calcium oxide
20-32%。
Powder granularity D90≤60 μm of the bioactivity silicon, specific surface area are 180-300 ㎡/g.
A kind of preparation method of pulvis that treating diabetic foot ulcer, it is characterised in that:
(1) it is ground to uniformly in mortar after mixing calamine stone, charred RADIX RUBIAE, vitamin c powder, is tentatively mixed；
(2) mixed powder described in bioactivity silicon and (1) is added in flour mill together, further crushes and mixes.
(3) mixed powder in (2) is subjected to hot air sterilization, pack.
The revolving speed of the flour mill is 800-1500r/min, grinding time 3-7min.
The hot air sterilization temperature is 100-130 DEG C, time 10-30min.
Beneficial effects of the present invention: this formula uses specific proportion, using bioactivity silicon as major ingredient, cooperates calamine, madder
The auxiliary elements such as turf, vitamin c powder mix, over the course for the treatment of can secretion that is antibacterial well and absorbing ulcer spot
Object improves local wound microenvironment, promotes the wound healing of diabetic foot ulcer, realizes the reparation weight of diabetic foot ulcer position blood vessel
Build, and after the completion of healing can dissolving stasis, promote blood circulation, fundamentally solve the problems, such as diabetic foot ulcer.
Specific embodiment
For further understanding of the invention, the present invention will be further described combined with specific embodiments below, is retouched
The embodiment stated is only a part of the embodiment of the present invention, instead of all the embodiments.
A kind of pulvis for treating diabetic foot ulcer, is made of the raw material of following parts by weight: bioactivity silicon 65-80
Part, 10-25 parts of calamine stone, 5-8 parts of charred RADIX RUBIAE, 1-3 parts of vitamin c powder.
The ingredient of the bioactivity silicon are as follows: without fixed kenel silica 50-75%, phosphorous oxides 8-15%, calcium oxide
20-32%。
Powder granularity D90≤60 μm of the bioactivity silicon, specific surface area are 180-300 ㎡/g.
A kind of preparation method of pulvis that treating diabetic foot ulcer,
(1) it is ground to uniformly in mortar after mixing calamine stone, charred RADIX RUBIAE, vitamin c powder, is tentatively mixed；
(2) mixed powder described in bioactivity silicon and (1) is added in flour mill together, further crushes and mixes.
(3) mixed powder in (2) is subjected to hot air sterilization, pack.
The revolving speed of the flour mill is 800-1500r/min, grinding time 3-7min.
The hot air sterilization temperature is 100-130 DEG C, time 10-30min.
Each embodiment group is grouped as table
| Component (parts by weight) | Embodiment one | Embodiment two | Embodiment three | Example IV |
| Bioactivity silicon (part) | 72 | 65 | 78 | 80 |
| Calamine stone (part) | 20 | 25 | 11 | 14 |
| Charred RADIX RUBIAE (part) | 6 | 7 | 8 | 5 |
| Vitamin c powder (part) | 2 | 3 | 3 | 1 |
Above-described embodiment preparation method is identical:
(1) it is ground to uniformly in mortar after mixing calamine stone, charred RADIX RUBIAE, vitamin c powder, is tentatively mixed；
(2) then the mixed powder of bioactivity silicon and above-mentioned (1) is added in flour mill together, with the speed of 1000r/min
It is pulverized and mixed 5min；
(3) mixed powder of (2) is then subjected to 100-130 DEG C of hot air sterilization 10-30min, is packed after cooling.
Preferably, the bioactivity silicon, be with containing 50-75% without based on fixed kenel silica, 8-15% phosphorus oxygen
Compound is inlayed wherein, and the calcium oxide of 20-32% is combined to form；Bioactivity silicon powder granularity: D90≤60 micron, specific surface
Product: 180-300m2/g, and containing the non-bridging oxygen of high concentration in structure, bioactivity with higher can be with inducing cell and group
Knit the wound healing for promoting diabetic foot ulcer from source Regeneration and Repair and as tissue especially the bracket of vascular repair process with
Bridge realizes the reconstruction of ulcer spot blood vessel.
Preferably, the fineness of powder after the calamine stone, charred RADIX RUBIAE are dry is 200-300 mesh.
Preferably, the vitamin c powder is medical grade, Han Liang≤99%.
Wherein bioactivity silicon is using the bioactivity of itself and with inducing cell and tissue from the function of source Regeneration and Repair
Can, promote the wound healing of diabetic foot ulcer and bracket and bridge as tissue especially vascular repair process, realizes and burst
The reconstruction of ulcer position blood vessel solves the problems, such as most intractable the most fundamental in diabetic ulcer treatment；Charred RADIX RUBIAE has promoting blood circulation
Dissolving stasis；Calamine can partially absorb wound extract, there is antibacterial, convergence, protective effect；Vitamin C can also promote being cured for ulcer
It closes and synergistic effect is played to bioactivity silicon.
Above-mentioned major ingredient bioactivity silicon and auxiliary agent calamine stone, charred RADIX RUBIAE, vitamin c powder compatibility, over the course for the treatment of
Energy is antibacterial well and absorbs the secretion of ulcer spot, improves local wound microenvironment, repairs for biological activated silica progress organization healing
Multiple, reconstructing blood vessel is laid the foundation, and after the completion of healing can dissolving stasis, promote blood circulation, above-mentioned formula each component collaboration is made
With can fundamentally solve the problems, such as diabetic foot ulcer.
Below with reference to clinical laboratory data, illustrate beneficial effects of the present invention, the difference of above-described embodiment is each component
Difference, but can reach it is of the present invention the utility model has the advantages that
To verify effect of the invention, diabetes are collected by hospital outpatient and diabetes control association in October, 2017 and are festered
Patient 152, observation tracking on probation has been carried out, as a result as follows:
One, object is observed:
152 patients, wherein male 84, female 68, the oldest person 83 years old, youngest person 28 years old, when wherein wound festers
Between the longest 1 year, time of festering most short person 7d；Wherein have to fester and spreads 42 people of symptom；According to the mode of random grouping of drawing lots
Patient is divided into four groups: being respectively 40 people, 37 people, 38 people, 37 people, uses embodiment one (being denoted as the 1st group), embodiment two respectively
(being denoted as the 2nd group), embodiment three (being denoted as the 3rd group), the corresponding powder samples of example IV (being denoted as the 4th group) are treated.
Two, treatment method:
First ulcer wound is cleaned with physiological saline or professional debridement liquid, is sterilized, is then uniformly spread pulvis of the present invention
On the surface of a wound, then by wound hospital gauze or profession application protection；Replacement in every 48 hours is primary.
Three, therapeutic effect:
1. criterion:
It is effective: after medication three times, remission；
Recovery from illness: ulcer Wound healing within medication 28 days, and pass through more than half a year without recurrence；
Invalid: repeatedly treatment symptom is not improved.
2. result
Treatment results statistics is as follows:
In the treatment, patient's symptom has alleviation after medication twice, and wound secretion is reduced, and wound is not being spread, some patientss
Ulcer spot has new granulation tissue to be formed, and shows as, obvious effective rate 100% effective to all patients；It is different after medication 28d
The cure rate of experimental group table as above.
Cure case:
Case one: patient male, 48 years old, diabetic foot ulcer can not heal, and be fully recovered using 28d after the treatment of one powder of embodiment.
Case two: female patient, 42 years old, diabetes caused ulcer that can not heal, and used 28d after the treatment of one powder of embodiment
Wound healing, skin restores as excellent as before after 60d.
Case three: male patient, 57 years old, diabetes cause foot ulcers that can not heal, use one powder of embodiment treat
14d, skin incrustation healing.
This product is induction tissue from the reparation of source property, and healing process not will form hyperblastosis, preventing from scar, after healing
Skin histology is as excellent as before, no recurrence.
The above, only presently preferred embodiments of the present invention, are not intended to limit the scope of the present invention.
Claims (6)
1. a kind of pulvis for treating diabetic foot ulcer, which is characterized in that be made of the raw material of following parts by weight: bioactivity
65-80 parts of silicon, 10-25 parts of calamine stone, 5-8 parts of charred RADIX RUBIAE, 1-3 parts of vitamin c powder.
2. a kind of pulvis for treating diabetic foot ulcer as described in claim 1, it is characterised in that: the bioactivity silicon at
It is divided into: without fixed kenel silica 50-75%, phosphorous oxides 8-15%, calcium oxide 20-32%.
3. a kind of pulvis for treating diabetic foot ulcer as claimed in claim 2, it is characterised in that: the powder of the bioactivity silicon
Body granularity D90≤60 μm, specific surface area are 180-300 ㎡/g.
4. a kind of preparation method for the pulvis for treating diabetic foot ulcer as described in claim 1, it is characterised in that:
(1) it is ground to uniformly in mortar after mixing calamine stone, charred RADIX RUBIAE, vitamin c powder, is tentatively mixed；
(2) mixed powder described in bioactivity silicon and (1) is added in flour mill together, further crushes and mixes；
(3) mixed powder in (2) is subjected to hot air sterilization, is packed after cooling.
5. a kind of preparation method for the pulvis for treating diabetic foot ulcer as claimed in claim 4, it is characterised in that: the milling
The revolving speed of machine is 800-1500r/min, grinding time 3-7min.
6. a kind of preparation method for the pulvis for treating diabetic foot ulcer as claimed in claim 4, it is characterised in that: described xeothermic
Sterilising temp is 100-130 DEG C, time 10-30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810711490.4A CN109662999A (en) | 2018-07-03 | 2018-07-03 | A kind of pulvis and preparation method thereof for treating diabetic foot ulcer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810711490.4A CN109662999A (en) | 2018-07-03 | 2018-07-03 | A kind of pulvis and preparation method thereof for treating diabetic foot ulcer |
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| CN109662999A true CN109662999A (en) | 2019-04-23 |
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| CN201810711490.4A Pending CN109662999A (en) | 2018-07-03 | 2018-07-03 | A kind of pulvis and preparation method thereof for treating diabetic foot ulcer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263615A (en) * | 2020-10-23 | 2021-01-26 | 温州医科大学慈溪生物医药研究院 | Composition containing bioglass ceramics and application thereof in treating diabetic foot ulcer |
| CN115591009A (en) * | 2022-10-27 | 2023-01-13 | 江苏阳生生物股份有限公司（Cn） | Dressing for promoting rapid repair of skin wound surface |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362214A (en) * | 2016-08-24 | 2017-02-01 | 北京幸福益生高新技术有限公司 | Regenerated silicon material as well as preparation method and application thereof |
-
2018
- 2018-07-03 CN CN201810711490.4A patent/CN109662999A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362214A (en) * | 2016-08-24 | 2017-02-01 | 北京幸福益生高新技术有限公司 | Regenerated silicon material as well as preparation method and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263615A (en) * | 2020-10-23 | 2021-01-26 | 温州医科大学慈溪生物医药研究院 | Composition containing bioglass ceramics and application thereof in treating diabetic foot ulcer |
| CN115591009A (en) * | 2022-10-27 | 2023-01-13 | 江苏阳生生物股份有限公司（Cn） | Dressing for promoting rapid repair of skin wound surface |
| CN115591009B (en) * | 2022-10-27 | 2023-09-26 | 江苏阳生生物股份有限公司 | Dressing for promoting rapid repair of skin wound surface |
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