CN105770058A - Traditional Chinese medicine composition for treating orthopedic diseases and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating orthopedic diseases and preparation method and application thereof Download PDFInfo
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- CN105770058A CN105770058A CN201610235273.3A CN201610235273A CN105770058A CN 105770058 A CN105770058 A CN 105770058A CN 201610235273 A CN201610235273 A CN 201610235273A CN 105770058 A CN105770058 A CN 105770058A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese medicine composition for treating orthopedic diseases and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 18-26 parts of herba patriniae, 15-25 parts of herb of spanishneedles, 3-10 parts of Chinese tallowtree root-bark and 30-38 parts of emilia sonchifolia.Chinese tallowtree root-bark is smashed, filtered and subjected to heat treatment and then Chinese tallowtree root-bark powder is obtained; 65% ethyl alcohol is added into herba patriniae, herb of spanishneedles and emilia sonchifolia, and soaking, boiling and filtering are conducted; two times of filtrate are combined, concentration is conducted, and a concentrated solution is obtained; the Chinese tallowtree root-bark powder is put in the concentrated solution, after heat treatment is conducted, the temperature is reduced to the room temperature, and the traditional Chinese medicine composition is obtained.By means of synergetic cooperation of the raw materials, the traditional Chinese medicine composition achieves the effects of invigorating the circulation of blood, strengthening bones, warming channels, expelling cold and activating meridians to stop pains.Clinically, the traditional Chinese medicine composition is mainly used for treating various orthopedic diseases such as osteoproliferation, arthritis, femoral head necrosis and traumatic injuries, the healing time is short, the cure rate is high, no toxic or side effect is caused, both symptoms and root causes are treated, relapse is avoided after healing, the preparation technology is simple, operation is easy, and the traditional Chinese medicine composition is beneficial to industrial application.
Description
Technical field
The present invention relates to pharmaceutical technology field, a kind of Chinese medicine composition treating orthopaedic disease and preparation method thereof and should
With.
Background technology
Along with the change of aged tendency of population and human lives with working method, orthopaedic disease is obvious ascendant trend.Bone clinically
Section's disease generally comprises cervical spondylosis, hyperosteogeny, arthritis, femur head necrosis, traumatic injury etc..Its clinical symptoms is main
Showing as affected part pain, redness, stiff, action obstacle etc., the course of disease is the longest, has had a strong impact on the orthobiosis of patient.Especially
It is femur head necrosis and hyperosteogeny, and not only the persistent period is long, is also difficult to cure.
At present, treat the pain medication that above-mentioned disease causes and mostly be Western medicine, such as: ibuprofen, tablet for alleviating pain etc., clinical effectiveness is relatively
Good, but side effect is bigger, it is impossible to play the effect of radical cure, recur after drug withdrawal, and the drug price having is higher, long
Take the financial burden adding patient period, the most also its health can be produced harmful effect.
Summary of the invention
It is an object of the invention to provide that a kind of healing time is short, cure rate is high, have no side effect, the controlling of non-relapse after healing
Treat Chinese medicine composition of orthopaedic disease and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine composition treating orthopaedic disease, is made up of according to the raw material of weight portion following: Herba Patriniae 18-26 part,
Herba Bidentis Bipinnatae 15-25 part, Cortex Sapii Radicis 3-10 part, purple back of the body grass 30-38 part.
As the further scheme of the present invention: the Chinese medicine composition of described treatment orthopaedic disease, by following former according to weight portion
Material composition: Herba Patriniae 20-24 part, Herba Bidentis Bipinnatae 18-22 part, Cortex Sapii Radicis 5-8 part, purple back of the body grass 32-36 part.
As the further scheme of the present invention: the Chinese medicine composition of described treatment orthopaedic disease, by following former according to weight portion
Material composition: Herba Patriniae 22 parts, Herba Bidentis Bipinnatae 20 parts, Cortex Sapii Radicis 7 parts, purple back of the body grass 34 parts.
The preparation method of the Chinese medicine composition of described treatment orthopaedic disease, comprises the steps of:
1) Cortex Sapii Radicis pulverized, cross 200 mesh sieves, then stir process 15-20min at 110-120 DEG C, prepare crow
Chinese tallow tree wood root bark powder is standby；
2) in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, add 65% ethanol of three's mass 12-14 times, and at 50-55 DEG C
Soaking 2-3 hour, heating is boiled 35-45 minute, filters, and filtrate is standby；Filtering residue adds the 65% of filtering residue quality 8-10 times
Ethanol, heated and boiled 20-25 minute, to filter, filtrate is standby；Merging the filtrate of twice, being concentrated into relative density is 1.30
Concentrated solution；
3) Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 5-8min at 80-85 DEG C, it is down to room temperature and i.e. obtains Chinese medicine
Compositions.
The application in preparation treatment orthopaedic disease medicine of the described Chinese medicine composition.
In the present invention, Herba Patriniae has heat-clearing and toxic substances removing, the effect of evacuation of pus of eliminating the phlegm.Cure mainly acute appendicitis, lung abscess, dysentery, postnatal blood stasis
Stomachache, carbuncle furuncle.
Herba Bidentis Bipinnatae has effect of heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis,
Acute icterohepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, furuncle, venom, treating swelling and pain by traumatic injury are controlled in external.
Cortex Sapii Radicis has diuretic, removing food stagnancy, parasite killing, removing toxic substances.Harness the river swollen, tympanites, lump in the abdomen, constipation and anuresis, eczema,
Scabies, furunculosis effect.
Purple back of the body grass antiinflammatory, dysentery relieving, cure mainly parotitis, mastitis, infantile malnutrition, skin eczema, menoxenia, abdomen in puerperal
Bitterly, the disease such as traumatic injury.
Compared with prior art, the invention has the beneficial effects as follows:
Raw material selected by the present invention is pure Chinese herbal medicine, by the coordinated of each raw material, makes medicine reach invigorate blood circulation bone strengthening, warming the meridian
Cold expelling, effect of removing obstruction in the collateral to relieve pain.It is mainly used in hyperosteogeny, arthritis, femur head necrosis, traumatic injury etc. clinically each
The treatment of kind of orthopaedic disease, healing time is short, cure rate is high, have no side effect, treating both the principal and secondary aspects of a disease, and instant safety is controlled
The recurrence after healing can be avoided.Preparation technology of the present invention is simple to operation, low cost, it is simple to industrial applications.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobvious
So, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine composition treating orthopaedic disease, it is made up of according to the raw material of weight portion following:
Herba Patriniae 18 parts, Herba Bidentis Bipinnatae 15 parts, Cortex Sapii Radicis 3 parts, purple back of the body grass 30 parts.
Cortex Sapii Radicis is pulverized, crosses 200 mesh sieves, then stir process 15min at 110 DEG C, prepare Cortex Sapii Radicis powder
Standby.The ethanol that volumetric concentration is 65% of addition three's mass 12 times in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, and
Soaking 2 hours at 50 DEG C, heating is boiled 35 minutes, filters, and filtrate is standby；Filtering residue adds the volume of filtering residue quality 8 times
Concentration is the ethanol of 65%, heated and boiled 20 minutes, filters, and filtrate is standby；Merge the filtrate of twice, be concentrated into relatively
Density is the concentrated solution of 1.30.Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 5min at 80 DEG C, it is down to room
Temperature i.e. obtains Chinese medicine composition.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine composition treating orthopaedic disease, it is made up of according to the raw material of weight portion following:
Herba Patriniae 26 parts, Herba Bidentis Bipinnatae 25 parts, Cortex Sapii Radicis 10 parts, purple back of the body grass 38 parts.
Cortex Sapii Radicis is pulverized, crosses 200 mesh sieves, then stir process 20min at 120 DEG C, prepare Cortex Sapii Radicis powder
Standby.In Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, add 65% ethanol of three's mass 14 times, and at 55 DEG C, soak 3
Hour, heating is boiled 45 minutes, filters, and filtrate is standby；Adding 65% ethanol of filtering residue quality 10 times in filtering residue, heating is boiled
Boiling 25 minutes, filter, filtrate is standby；Merge the filtrate of twice, be concentrated into the concentrated solution that relative density is 1.30.By crow
Chinese tallow tree wood root bark powder is inserted in concentrated solution, and stir process 8min at 85 DEG C is down to room temperature and is i.e. obtained Chinese medicine composition.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine composition treating orthopaedic disease, it is made up of according to the raw material of weight portion following:
Herba Patriniae 20 parts, Herba Bidentis Bipinnatae 18 parts, Cortex Sapii Radicis 5 parts, purple back of the body grass 32 parts.
Cortex Sapii Radicis is pulverized, crosses 200 mesh sieves, then stir process 20min at 115 DEG C, prepare Cortex Sapii Radicis powder
Standby.The ethanol that volumetric concentration is 65% of addition three's mass 13 times in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, and
Soaking 2.5 hours at 52 DEG C, heating is boiled 40 minutes, filters, and filtrate is standby；Filtering residue adds the volume of filtering residue quality 9 times
Concentration is the ethanol of 65%, heated and boiled 25 minutes, filters, and filtrate is standby；Merge the filtrate of twice, be concentrated into relatively
Density is the concentrated solution of 1.30.Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 7min at 82 DEG C, it is down to room
Temperature i.e. obtains Chinese medicine composition.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine composition treating orthopaedic disease, it is made up of according to the raw material of weight portion following:
Herba Patriniae 20-24 part, Herba Bidentis Bipinnatae 18-22 part, Cortex Sapii Radicis 5-8 part, purple back of the body grass 32-36 part.
Cortex Sapii Radicis is pulverized, crosses 200 mesh sieves, then stir process 20min at 115 DEG C, prepare Cortex Sapii Radicis powder
Standby.The ethanol that volumetric concentration is 65% of addition three's mass 13 times in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, and
Soaking 2.5 hours at 52 DEG C, heating is boiled 40 minutes, filters, and filtrate is standby；Filtering residue adds the volume of filtering residue quality 9 times
Concentration is the ethanol of 65%, heated and boiled 25 minutes, filters, and filtrate is standby；Merge the filtrate of twice, be concentrated into relatively
Density is the concentrated solution of 1.30.Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 7min at 82 DEG C, it is down to room
Temperature i.e. obtains Chinese medicine composition.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine composition treating orthopaedic disease, it is made up of according to the raw material of weight portion following:
Herba Patriniae 22 parts, Herba Bidentis Bipinnatae 20 parts, Cortex Sapii Radicis 7 parts, purple back of the body grass 34 parts.
Cortex Sapii Radicis is pulverized, crosses 200 mesh sieves, then stir process 20min at 115 DEG C, prepare Cortex Sapii Radicis powder
Standby.The ethanol that volumetric concentration is 65% of addition three's mass 13 times in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, and
Soaking 2.5 hours at 52 DEG C, heating is boiled 40 minutes, filters, and filtrate is standby；Filtering residue adds the volume of filtering residue quality 9 times
Concentration is the ethanol of 65%, heated and boiled 25 minutes, filters, and filtrate is standby；Merge the filtrate of twice, be concentrated into relatively
Density is the concentrated solution of 1.30.Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 7min at 82 DEG C, it is down to room
Temperature i.e. obtains Chinese medicine composition.
Comparative example 1
In addition to not containing Cortex Sapii Radicis, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only Cortex Sapii Radicis, its preparation process is consistent with embodiment 5.
In order to prove the therapeutic effect of Chinese medicine composition of the present invention, carry out following experiments
One, toxicity test
The Chinese medicine composition of the present invention is that one can treat femur head necrosis, hyperosteogeny, various traumatic injury and arthritis
Special effect Chinese preparation, existing as a example by the Chinese medicine composition that embodiment 5 prepares, carry out studies on acute toxicity.
1, experiment material
1.1 medicines: the Chinese medicine composition that embodiment 5 is made.
1.2 animals: mice, Kunming kind, body weight 18-22 gram, male and female all use, purchased from Shandong anti-Pharmaceutical Group Lu Yuan branch company
Experimental Animal Center.
2, method and result
Take body weight 18-22 gram kunming mice 10, male and female half and half, gavage this product 33mg/10 gram, normally raise,
Observe seven days.
Result: animal is taken food, drinking-water, fur, extremity are movable the most without exception with behavior etc., and body weight increases, and dissects naked eyes and sees
Wipe, main organs no abnormality seen.
3, brief summary and discussion
Gavage 33mg/10 gram of the present invention, seeing to wipe has any toxic reaction less than animal to this, due to by preparation and perfusion
Approach consumption is limited, and gavage cannot obtain the mice median lethal dose(LD 50) to bone growth promoting ball, can only substantially calculate that gavage of mice is raw
The maximum tolerated dose (MTO) of bone ball is more than 33mg/10g.This dose is calculated by kg body weight, is equivalent to people's dose
More than 100 times, the medicine of embodiment 5 is safe without toxic side effect in the case of oral.
It is the most without exception that medicine obtained in other scope of the invention carries out toxicity test.
Two, zoopery
1, case source
Certain province 1050 patient of various big hospital random choose as drug use volunteer, wherein hyperosteogeny patient 350
Example, Patients with Aseptic Necrosis of Femoral 350 example, traumatic injury Patients Patients 350 example.Wherein, male patient 600, women suffers from
Person 450, patient age is between 35-65 year, and patient's mild or moderate, moderate, the severe state of an illness all have, and the severe state of an illness accounts for 20-30%,
State of an illness judgment basis country relevant regulations.
2, experimental technique
Hyperosteogeny patient is equally divided into 7 groups according to sex, age, the state of an illness, often organizes 50 examples, wherein treatment group totally five
Group, is respectively treatment 1 group, treats 2 groups, treats 3 groups, treats 4 groups, treats 5 groups, use embodiment 1-5 respectively
Medicine, matched group totally 2 groups, it is respectively comparison 1 group, compares 2 groups, use comparative example 1-2 medicine respectively, respectively organize patient
Age, sex, the course of disease and severity extent aspect comparing difference without significance (P ＞ 0.05), there is comparability.
Patients with Aseptic Necrosis of Femoral, traumatic injury patient carry out being grouped and dispenser the most according to the method described above.
3, application method
The medicine of embodiment 1-5 prepared according to the inventive method and comparative example 1-2 is granted patient respectively, and application method is
2g every time, 2 times on the one.
4, criterion
Effective: after using one month, state of an illness recovery from illness or substantially alleviate, the transference cure such as pain, numbness, swelling or substantially disappear
Lose；
Effective: after using one month, the state of an illness has been alleviated, the symptom such as pain, numbness, swelling substantially alleviates；
Invalid: after using one month, the state of an illness is without alleviating or aggravation.
5, experimental result
Table 1 hyperosteogeny patient treatment situation
| Group | Total number of cases | Effective | Effectively | Invalid | Total effective rate % |
| Treat 1 group | 50 | 43 | 6 | 1 | 98 |
| Treat 2 groups | 50 | 44 | 5 | 1 | 98 |
| Treat 3 groups | 50 | 47 | 3 | 0 | 100 |
| Treat 4 groups | 50 | 48 | 2 | 0 | 100 |
| Treat 5 groups | 50 | 50 | 0 | 0 | 100 |
| Compare 1 group | 50 | 1 | 18 | 31 | 38 |
| Compare 2 groups | 50 | 0 | 6 | 44 | 12 |
Table 2 Patients with Aseptic Necrosis of Femoral treatment situation
| Group | Total number of cases | Effective | Effectively | Invalid | Total effective rate % |
| Treat 1 group | 50 | 41 | 7 | 2 | 96 |
| Treat 2 groups | 50 | 42 | 7 | 1 | 98 |
| Treat 3 groups | 50 | 45 | 5 | 0 | 100 |
| Treat 4 groups | 50 | 46 | 4 | 0 | 100 |
| Treat 5 groups | 50 | 50 | 0 | 0 | 100 |
| Compare 1 group | 50 | 1 | 16 | 33 | 34 |
| Compare 2 groups | 50 | 0 | 4 | 46 | 8 |
Table 3 traumatic injury patient treatment situation
| Group | Total number of cases | Effective | Effectively | Invalid | Total effective rate % |
| Treat 1 group | 50 | 45 | 4 | 1 | 98 |
| Treat 2 groups | 50 | 46 | 4 | 0 | 100 |
| Treat 3 groups | 50 | 47 | 3 | 0 | 100 |
| Treat 4 groups | 50 | 48 | 2 | 0 | 100 |
| Treat 5 groups | 50 | 50 | 0 | 0 | 100 |
| Compare 1 group | 50 | 1 | 22 | 27 | 46 |
| Compare 2 groups | 50 | 0 | 8 | 16 | 16 |
6, experiment conclusion
From above-mentioned experimental result it can be seen that medicine of the present invention is bad to hyperosteogeny, femoral head under the common effect of each raw material
Extremely, traumatic injury all have good therapeutic effect, and this cured substance time is short, onset equal to most patients, effective percentage
Height, has no side effect, non-relapse after healing.
Case 1
Grandson, man, 45 years old, suffer from femur head necrosis 7 years, often have an injection, oral multiple Chinese and western drugs, hurt like hell, shadow
Ring sleep, it is impossible to walking of leaving the bed.Take the embodiment of the present invention 5 medicine, the same day pain relief, state of an illness recovery from illness after month.
Case 2
Week certain, man, 62 years old, suffer from hyperosteogeny, take the present invention, the same day pain relief, state of an illness recovery from illness after month.
Case 3
Wu, man, 35 years old, during motion leg soft tissue of joint damage, swell and ache unbearably, the same day pain relief, a Zhou Houhang
Move freely.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only comprises
One independent technical scheme, this narrating mode of description is only the most for clarity sake, and those skilled in the art should be by
Description is as an entirety, and the technical scheme in each embodiment can also be through appropriately combined, and forming those skilled in the art can
With other embodiments understood.
Claims (5)
1. the Chinese medicine composition treating orthopaedic disease, it is characterised in that be made up of according to the raw material of weight portion following: lose
Beans grass 18-26 part, Herba Bidentis Bipinnatae 15-25 part, Cortex Sapii Radicis 3-10 part, purple back of the body grass 30-38 part.
The Chinese medicine composition for the treatment of orthopaedic disease the most according to claim 1, it is characterised in that by following according to weight
The raw material composition of part: Herba Patriniae 20-24 part, Herba Bidentis Bipinnatae 18-22 part, Cortex Sapii Radicis 5-8 part, purple back of the body grass 32-36 part.
The Chinese medicine composition for the treatment of orthopaedic disease the most according to claim 2, it is characterised in that by following according to weight
The raw material composition of part: Herba Patriniae 22 parts, Herba Bidentis Bipinnatae 20 parts, Cortex Sapii Radicis 7 parts, purple back of the body grass 34 parts.
4. a preparation method for the Chinese medicine composition of the treatment orthopaedic disease as described in claim 1-3 is arbitrary, its feature exists
In, comprise the steps of:
1) Cortex Sapii Radicis pulverized, cross 200 mesh sieves, then stir process 15-20min at 110-120 DEG C, prepare crow
Chinese tallow tree wood root bark powder is standby；
2) in Herba Patriniae, Herba Bidentis Bipinnatae, purple back of the body grass, add 65% ethanol of three's mass 12-14 times, and at 50-55 DEG C
Soaking 2-3 hour, heating is boiled 35-45 minute, filters, and filtrate is standby；Filtering residue adds the 65% of filtering residue quality 8-10 times
Ethanol, heated and boiled 20-25 minute, to filter, filtrate is standby；Merging the filtrate of twice, being concentrated into relative density is 1.30
Concentrated solution；
3) Cortex Sapii Radicis powder is inserted in concentrated solution, stir process 5-8min at 80-85 DEG C, it is down to room temperature and i.e. obtains Chinese medicine
Compositions.
5. the application in preparation treatment orthopaedic disease medicine of the Chinese medicine composition as described in claim 1-3 is arbitrary.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943656A (en) * | 2016-06-03 | 2016-09-21 | 山东省文登整骨医院 | Traditional Chinese medicine composition for treating orthopedic diseases and preparation method and application thereof |
| CN106038712A (en) * | 2016-08-11 | 2016-10-26 | 温州医科大学附属第二医院 | Traditional Chinese medicinal preparation for treating orthopedic diseases, and preparation method and application thereof |
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| 南京中医药大学编著: "《中药大辞典》", 31 March 2006 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943656A (en) * | 2016-06-03 | 2016-09-21 | 山东省文登整骨医院 | Traditional Chinese medicine composition for treating orthopedic diseases and preparation method and application thereof |
| CN106038712A (en) * | 2016-08-11 | 2016-10-26 | 温州医科大学附属第二医院 | Traditional Chinese medicinal preparation for treating orthopedic diseases, and preparation method and application thereof |
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