CN103494882A - Traditional Chinese medicine preparation for promoting wound healing and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for promoting wound healing and preparation method thereof Download PDF

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CN103494882A
CN103494882A CN201310449727.3A CN201310449727A CN103494882A CN 103494882 A CN103494882 A CN 103494882A CN 201310449727 A CN201310449727 A CN 201310449727A CN 103494882 A CN103494882 A CN 103494882A
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韦成旺
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Abstract

The invention provides a traditional Chinese medicine preparation for promoting wound healing. The traditional Chinese medicine preparation comprises bulk drugs of the traditional Chinese medicine in parts by weight: 48-54 parts of wind mugwort, 28-32 parts of camphor branches and 18-22 parts of kapur branches. The preparation method comprises the following steps of: taking materials; preparing salty water; preparing; decocting and the like. The traditional Chinese medicine preparation is rational in formula, has the effects of invigorating the circulation of blood and dissipating decoction, warming channel to remove coldness and relieving pain, relaxing the muscles and stimulating the blood circulation, festering and converging boils, removing the necrotic tissue and promoting granulation and the like through cooperative function of the drugs, treating wound infection, inflammation, swelling, water flow, suppuration and long treatment of the surface of the skin, and has the effects of treating both symptoms and root causes and realizing no relapse after healing; the preparation method is simple, and the production cost is low.

Description

Promote Chinese medicine preparation of wound healing and preparation method thereof
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine preparation that promotes wound healing and preparation method thereof.
Background technology
Wound healing is a complexity and the strict process of controlling, and relates to dissimilar cell and a large amount of somatomedin and cytokines.These somatomedin and cytokine have its specific role in the stage of wound healing.The physiological imbalance may be disturbed wound healing, thereby forms cicatrix or delayed union.The purpose of Wound healing and bone regeneration is to optimize agglutination at present, for different wound healings, by supplementary means, realizes the individual treatment of optimizing.
Method and the Chinese and western drugs of the wound healing of great majority treatment now are directly the gluing liquid of Mel or Aloe to be embrocated on skin or wound; wound is protected; prevent infection and the dehydration of wound; reach antiinflammatory, pain relieving, stop blooding, alleviate edema, promote the purpose of wound healing; severe patient is to spray the medicine of antibiotic medicine cephalo and so on, the additional Western medicine that eats of amoxicillin and so on.But for inflammation, redness, flowing water, suppurated, the obstinate person, these medicines may not reach effect, and Western medicine is also large to the side effect of health.At present, increasing people tends to adopt the treatment by Chinese herbs wound healing, and Chinese medicine can significantly promote the healing of skin wound, promotes the epidermis epithelization, promotes that epidermal stem cells distributes again, thereby improves the quality of healing, little to the side effect of health.
Patent documentation application number CN201010157915.5 discloses " a kind of Chinese medicine composition that promotes wound healing and preparation method thereof ", and it is comprised of following crude drug: Radix Angelicae Sinensis 2-5%, Radix Glycyrrhizae 1.5-3%, the Radix Angelicae Dahuricae 1-2%, Sanguis Draxonis 1.5-4%, Olibanum 1-2.5%, Myrrha 1-2.5%, catechu 1-2.5%, Radix Arnebiae (Radix Lithospermi) 1.5-4%, Calomelas 1-2.0%, Camphora 0.4-0.8%, Borneolum Syntheticum 0.4-0.8%, Moschus 0.01-0.20%, white beeswax 9-12.7%, Oleum Sesami 38.3-62.5%, vaseline 0-38.3%.Its preparation method: first Radix Angelicae Sinensis, Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, part catechu and Radix Arnebiae (Radix Lithospermi) are dropped in Oleum Sesami and soak, decoct, drag for medicinal residues; Drop into again Sanguis Draxonis, continue to decoct, make Oleum Sesami maintain 180-210 ℃, then drop into successively white beeswax, vaseline, Camphora powder, borneol powder, from fire, finally drop into mixed-powder and the Calomelas powder of Moschus and part catechu, but this Chinese medicine decocts temperature requirement and maintains 180-210 ℃ in preparation process, high to decocting equipment requirements, and also composition is many, preparation technology's more complicated, cost is also higher.
Patent documentation application number CN02114046.4 discloses a kind of " ointment for wound healing ", it is by blood agglomeration 0.5-2 part, Myrrha 2-6 part, Radix Et Rhizoma Rhei 6-12 part, Radix Angelicae Sinensis 2-6 part, Rhizoma Paridis 2-9 part, the extractum that the crude drug of Borneolum Syntheticum 0.1-1.5 part weight proportion is made, the stickup cream that adds medical grade rubber to make this extractum, the healing district of pasting cream is right against wound, pastille medical grade rubber cream applying area and medical grade rubber cream applying area are placed in the wound both sides, by wound circumference cell Transdermal absorption, improve the wound circumference microcirculation, excitement is not damaged cell and is reached the activation damaged cell, recover the not tip of nerve, reduce the damaged part biologic resistance, promote physiological to repair skin function.This shows, this extractum need to coordinate medical grade rubber to use just can reach the effect of healing of wound, the use procedure inconvenience.
In sum, some medicine does not also have obvious therapeutic effect to the treatment wound healing, and some drug use gets up not to be easily, treats side effect large, and preparation technology is more complicated also, and expense is also higher, to the patient, increases financial burden.
Summary of the invention
The objective of the invention is the defect existed in existing Drug therapy, provide a kind of easy to use, preparation is simple, can effectively promote Chinese medicine preparation of wound healing and preparation method thereof.
For solving the problems of the technologies described above, technical scheme provided by the invention is: a kind of Chinese medicine preparation that promotes wound healing, comprise the raw material of Chinese medicine medicine, described raw material of Chinese medicine medicine is 48~54 parts of strong wind Folium Artemisiae Argyis, 28~32 parts, Camphora branch, 18~22 parts, Borneolum Syntheticum branch by weight ratio.
Preferably, the weight portion proportioning of described raw material of Chinese medicine medicine is 50 parts of strong wind Folium Artemisiae Argyis, 30 parts, Camphora branch, 20 parts, Borneolum Syntheticum branch.
The present invention also provides the preparation method of the Chinese medicine preparation of above-mentioned promotion wound healing, comprises the following steps:
(1) draw materials: the proportioning by the crude drug compositions is chosen raw medicinal material, washes clean and dries;
(2) produce saline: brine strength is 0.8~1.0%;
(3) concoct: strong wind Folium Artemisiae Argyi, Camphora branch, Borneolum Syntheticum branch crude drug compositions are added in light salt brine and soak, and soak time is 23~26 hours, and the weight summation of crude drug compositions and light salt brine are in 1:(3~4) ratio;
(4) boil: after immersion, first with big fire, be heated to boil, use moderate heat after boiling instead and boil, concentrate, extract plant essence, the time of boiling is 3 ± 0.5 hours, finally filters, and the bottling sterilizing, form Chinese medicine preparation.
Each material medicine of Chinese medicine preparation of the present invention has following character and effect:
1, strong wind Folium Artemisiae Argyi: hot, micro-hardship, tepor.There is the detumescence of dispeling the wind, the effect of promoting blood circulation to remove blood stasis.Cure mainly flu, rheumatic arthritis, joint swells and ache, and foot is soft unable, puerperal exposure to wind pain, dysmenorrhea; Traumatic injury is controlled in external, furuncle carbuncle, eczema, dermatitis, skin pruritus.
2, Camphora branch: hot, heat, poisonous.GUIXIN, spleen channel.Have the dehumidifying parasite killing, warming and odynolysis, have one's ideas straightened out and ward off dirty effect.Cure mainly scabies pruritus, traumatic pain, toothache.The central nervous system is had to excited effect simultaneously; Be applied to skin gentle stimulation and antisepsis are arranged; Firmly embrocated and sent out effect red, can stimulate Cold receptor and refrigerant sense is arranged, can antipruritic pain relieving, slight local anesthesia effect is arranged; Gastrointestinal tract is also had to stimulation, make the gastrointestinal snugness, but produce nausea and vomiting in a large number.In addition, oral Camphora has wind dispelling and slight phlegm-dispelling functions.
3, Borneolum Syntheticum branch: property of medicine suffering; Bitter; Cool.Return careful; Lung meridian.There is the refreshment of having one's ideas straightened out; The heat radiation pain relieving; The effect of improving eyesight removing nebula.Cure mainly the apoplexy locked mouth; The calentura coma; Infantile convulsion expectorant fan; Deafness with qi stagnation; Conjunctivitis; Sore throat; Aphtha; Carbuncle; Hemorrhoid; Enterobiasis.In addition, do weekly a Borneolum Syntheticum stifling, the energy relaxing muscles and tendons to promote blood circulation, make the skin children sliding, increases skin elasticity, is the standing good merchantable brands of domestic.
The present invention treats the skin surface traumatic infection, inflammation, redness, flowing water, the obstinate person suppurates, at first decoct water with the Chinese medicine Folium Artemisiae Argyi and clean wound face, after spray the wound healing Chinese medicine preparation, spray in 2 hours is once, wound can be in 24 hours dry and comfortable scabbing, change spray in 3 hours after scabbing into once, till being sprayed onto scar and coming off, more after preventing from scar.
The formula of Chinese medicine preparation of the present invention is reasonable, each drug synergism, there is the effects such as promoting blood circulation to remove blood stasis, warming and odynolysis, relaxing muscles and tendons to promote blood circulation, suppuration sore, removing the necrotic tissue and promoting granulation, the traumatic infection for the treatment of skin surface, inflammation, red and swollen, flowing water, suppurate and the disease such as control for a long time, and treating both the principal and secondary aspects of a disease is arranged, the effect do not recurred after reaching more, have advantages of easy to use, preparation is simple, toxic and side effects is little, can effectively promote wound healing.
The specific embodiment
Below in conjunction with embodiment, Chinese medicine preparation of the present invention and preparation method thereof is described in further detail.
Embodiment 1
The weight proportion of the crude drug compositions of Chinese medicine preparation is: 50 parts of strong wind Folium Artemisiae Argyis, 30 parts, Camphora branch, 20 parts, Borneolum Syntheticum branch.
The preparation method of this group crude drug compositions is:
(1) choose strong wind Folium Artemisiae Argyi 50g, Camphora branch 30g, Borneolum Syntheticum branch 20g by the proportioning of crude drug compositions, wash clean and dry;
(2) take out the water of 300g, add the salt of 2.7g, 0.9% of the quality that quality of salt is water, stirring and dissolving is produced light salt brine;
(3) strong wind Folium Artemisiae Argyi, Camphora branch, the mixing of Borneolum Syntheticum branch are added in light salt brine and soak, soak 25 hours;
(4) after soaking, first with big fire, be heated to boil, use moderate heat after boiling instead and boil, concentrate, extract plant essence, the time of boiling is 3 hours, finally filters, and the bottling sterilizing, form traditional Chinese medicine liquid.
Embodiment 2
The proportioning of the crude drug compositions of Chinese medicine preparation is: 54 parts of strong wind Folium Artemisiae Argyis, 28 parts, Camphora branch, 18 parts, Borneolum Syntheticum branch.
Its preparation method: choose strong wind Folium Artemisiae Argyi 54g, Camphora branch 28g, Borneolum Syntheticum branch 18g by the proportioning of crude drug compositions, wash clean and dry; Then take out the water of 350g, add the salt of 2.8g, 0.8% of the quality that quality of salt is water, stirring and dissolving is produced light salt brine; Again strong wind Folium Artemisiae Argyi, Camphora branch, Borneolum Syntheticum branch are mixed to add in light salt brine and soak, soak 23 hours; Boiled after immersion, at first be heated to boil with big fire, use moderate heat after boiling instead and boil, concentrate, extract plant essence, the time of boiling is 3 hours; Finally filter, the bottling sterilizing, form traditional Chinese medicine liquid.
Embodiment 3
The proportioning of the crude drug compositions of Chinese medicine preparation is: 48 parts of strong wind Folium Artemisiae Argyis, 32 parts, Camphora branch, 20 parts, Borneolum Syntheticum branch.
Its preparation method: choose strong wind Folium Artemisiae Argyi 48g, Camphora branch 32g, Borneolum Syntheticum branch 20g by the proportioning of crude drug compositions, wash clean and dry; Then take out the water of 400g, add the salt of 4g, 1.0% of the quality that quality of salt is water, stirring and dissolving is produced light salt brine; Again strong wind Folium Artemisiae Argyi, Camphora branch, Borneolum Syntheticum branch are mixed to add in light salt brine and soak, soak 26 hours; Boiled after immersion, at first be heated to boil with big fire, use moderate heat after boiling instead and boil, concentrate, extract plant essence, the time of boiling is 3 hours; Finally filter, the bottling sterilizing, form traditional Chinese medicine liquid.
Below further set forth the beneficial effect of Chinese medicine preparation of the present invention by test example, these test examples have comprised animal experiment and the clinical observation on the therapeutic effect test of Chinese medicine preparation of the present invention.
One, Chinese medicine preparation of the present invention promotes the animal experiment of wound healing.
1, test material:
Animal: 25 of white mice, male and female half and half, body weight 20g ± 4g, be divided into five groups of A, B, C, D, E, 5 every group at random.
Material: the Chinese medicine preparation of the embodiment of the present invention one, two, three, the ether of 35-37%, mercurochrome, ethanol, scalpel, shaver.
2, experimental condition:
In isolator, raise, temperature between 15-25 ℃, humidity between 50-65%, light and shade each 12 hours.
3, embodiment:
(1) with the ether of 35-37%, cause 25 white mice in slight comatose state, with shaver, shave out at the back of 25 white mice the part that area is 2 * 2cm respectively; Then shaving on hair side with the scalpel cutter (wound depth 0.2cm, length 2cm, have blood to ooze out) that rows dry 25 white mice respectively.
(2) A, B, C group: at first the wound face of white mice is decocted to water with the Chinese medicine Folium Artemisiae Argyi and clean, then the A group is sprayed the wound healing Chinese medicine preparation of the embodiment of the present invention one, the B group is sprayed the wound healing Chinese medicine preparation of embodiment, and the C group is sprayed the wound healing Chinese medicine preparation of embodiment tri-; Spray in 2 hours once, changes spray in 3 hours into once after scabbing, except evening, finish to experiment.
(3) the white mice wound of D group: D group only is coated with mercurochrome; Spray in 2 hours once, except evening, finishes to experiment.
(4) only simply disinfect with ethanol the white mice wound of E group: E group.
4, result of the test: (seeing the following form)
Table 1: animal experiment wound healing information slip
Figure BDA0000386407180000051
Figure BDA0000386407180000061
As can be seen from the above table, the white mice wound that is sprayed with Chinese medicine preparation of the present invention is compared with other wounds and is obtained comparatively fast, healing preferably, and meeting preventing from scar more, thereby also proved that Chinese medicine preparation of the present invention has good sterilization, analgesia, promote to organize effect more living and metabolism and blood circulation promoting, there is the effects such as promoting blood circulation to remove blood stasis, warming and odynolysis, relaxing muscles and tendons to promote blood circulation, suppuration sore, removing the necrotic tissue and promoting granulation, to promoting having a significant effect of wound healing.
Two, clinical observation on the therapeutic effect test
1, physical data
Patient's 350 examples, male's 200 examples, women's 150 examples, 15~25 years old age, 60 examples, 25~35 years old 157 example, 35~45 years old 76 example, 57 examples more than 45 years old.
2, Therapeutic Method
Select the embodiment Chinese medicine preparation of above-described embodiment 1, if wound is arranged, first with the Chinese medicine Folium Artemisiae Argyi, decoct water and clean wound face, after spray wound healing Chinese medicine preparation of the present invention, spray in 2 hours once, changes spray in 3 hours into once after scabbing; If there is no wound, directly spray wound healing Chinese medicine preparation of the present invention, spray in 3 hours is once; In the medication process, be all be sprayed onto scar and come off till, more after preventing from scar.
3, therapeutic effect
Through observing, be sprayed with in Chinese medicine preparation process of the present invention, dry and comfortable scabbing in wound 24 hours, three days scars that healed and occurred, a week cicatrix can automatically take off, Reusability, severe one is slightly long the course for the treatment of, and overall treatment time is 10-40 days, and therapeutic effect is all apparent in view, and preventing from scar more, concrete condition refers to table 2.
Table 2:350 example wound patient observation of curative effect table
Figure BDA0000386407180000071
As can be seen from the above table, in above-mentioned treatment, treat after 10-40 days, this organizes 350 examples, cures 236 examples, cure rate 67.43%; Produce effects 88 examples, obvious effective rate 25.14%; Effective 23 examples, effective percentage 6.57%; Invalid 3 examples, inefficiency 0.86%; Total effective rate reaches 99.14%; Chinese medicine preparation instant effect of the present invention is described, cure rate is high, has no side effect, and safety is good.
Model case:
Case 1: patient Chen, the man, 27, in year, at the beginning of 2012, the foot middle finger third finger is injured by a crashing object by stone, and through the treatment of local commune hospital, wound loses recovery from illness, comes to go to a doctor, and checks, and phalanges is shown in dew, and injury is even somewhat rotten, without regeneration capacity.Process, first with the Chinese medicine Folium Artemisiae Argyi, decoct water and clean wound face, after spray wound healing Chinese medicine preparation of the present invention, within 2 hours, spray once, change spray in 3 hours after scabbing into once, wound healing after 20 days, continue medication to 28 day, wound healing, continue medication to 30 day, scar comes off again, and does not stay any cicatrix.
Case 2: Dong so-and-so, man, 32 years old, left hand arm fracture, sit the operation fixation for treatment, but surgical wound and outer fixedly draw point wound lose healing, and the operation skin ulcer is festered, undisguised, hospital's suggestion is done and is mended the meat skin grafting, mend the meat skin grafting and do not protect successfully, the patient disagrees with, in May, 2011, comes to go to a doctor, on inspection, wound is skin ulcer clearly, and the wound intuition is very micro-, before growth retardation not, wound with the operation heavy damage the normal operation of blood.Process, first with the Chinese medicine Folium Artemisiae Argyi, decoct water cleaning wound face, after spray wound healing Chinese medicine preparation of the present invention, spray in 2 hours once, changes spray in 3 hours into once, medication 10 days after scabbing, taking a turn for the better appears in the wound situation, and wound healing after 20 days continues medication to 30 day, wound is almost recovered, continue medication to 35 day, scar comes off again, after 45 days, scar all comes off, and does not stay any cicatrix.
Case 3: Lee so-and-so, the female, 41 years old, the peasant, within 2 years, because being tied to one's bed, the buttocks large tracts of land is festered, and forms decubital ulcer, within 2011, uses Chinese medicine preparation of the present invention, recovery from illness in 25 days, the recurrence of following up a case by regular visits to that so far there are no.
Case 4: Zhang, 15 years old, the man, the student, the left index finger wound of lancinating because of carelessness, undisguised, decoct water with the Chinese medicine Folium Artemisiae Argyi and clean wound face, after spray wound healing Chinese medicine preparation of the present invention, spray in 2 hours once, changes 3 hours into and sprays once after scabbing.In the medication process, within 5 days, wound starts to scab, and within 8 days, scar starts to come off, and within 10 days, is almost recovered, and within 12 days, scar all comes off, and does not stay any cicatrix.
It should be noted that, these are only preferred embodiment of the present invention, conceive under prerequisite not breaking away from the present invention, any minor variations that the present invention is done and be equal to replacement, all belong to protection scope of the present invention.

Claims (3)

1. a Chinese medicine preparation that promotes wound healing, comprise the raw material of Chinese medicine medicine, it is characterized in that: described raw material of Chinese medicine medicine is 48~54 parts of strong wind Folium Artemisiae Argyis, 28~32 parts, Camphora branch, 18~22 parts, Borneolum Syntheticum branch by weight ratio.
2. the Chinese medicine preparation of promotion wound healing according to claim 1, it is characterized in that: the weight portion proportioning of described raw material of Chinese medicine medicine is 50 parts of strong wind Folium Artemisiae Argyis, 30 parts, Camphora branch, 20 parts, Borneolum Syntheticum branch.
3. a method for preparing the Chinese medicine preparation of promotion wound healing as claimed in claim 1 or 2 is characterized in that comprising the following steps:
(1) draw materials: the proportioning by the crude drug compositions is chosen raw medicinal material, washes clean and dries;
(2) produce saline: brine strength is 0.8~1.0%;
(3) concoct: strong wind Folium Artemisiae Argyi, Camphora branch, Borneolum Syntheticum branch crude drug compositions are added in light salt brine and soak, and soak time is 23~26 hours, and the weight summation of crude drug compositions and light salt brine are in 1:(3~4) ratio;
(4) boil: after immersion, first with big fire, be heated to boil, use moderate heat after boiling instead and boil, concentrate, extract plant essence, the time of boiling is 3 ± 0.5 hours, finally filters, and the bottling sterilizing, form Chinese medicine preparation.
CN201310449727.3A 2013-09-24 2013-09-24 Traditional Chinese medicine preparation for promoting wound healing and preparation method thereof Pending CN103494882A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103933105A (en) * 2014-03-31 2014-07-23 覃志友 Traditional Chinese medicine composition for trauma and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1259361A (en) * 1998-11-11 2000-07-12 李志方 Chinee medicinal power for treating toothache and its prepn. method
CN1565581A (en) * 2003-06-29 2005-01-19 王正坤 Immune function regulating antibiotic and anti-inflammatory drug with broad spectrum
CN102600363A (en) * 2012-03-15 2012-07-25 沈慰平 Traditional Chinese compound preparation for deep burnt wound restoration and tissue and skin regeneration promotion and preparation method of traditional Chinese compound preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1259361A (en) * 1998-11-11 2000-07-12 李志方 Chinee medicinal power for treating toothache and its prepn. method
CN1565581A (en) * 2003-06-29 2005-01-19 王正坤 Immune function regulating antibiotic and anti-inflammatory drug with broad spectrum
CN102600363A (en) * 2012-03-15 2012-07-25 沈慰平 Traditional Chinese compound preparation for deep burnt wound restoration and tissue and skin regeneration promotion and preparation method of traditional Chinese compound preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103933105A (en) * 2014-03-31 2014-07-23 覃志友 Traditional Chinese medicine composition for trauma and preparation method thereof

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Application publication date: 20140108