CN1096455A - The Chinese patent medicine of a kind of prevention and treatment neurasthenia and " preexam psychentonia syndrome " - Google Patents

Abstract

The present invention is the neurasthenic Chinese patent medicine of a kind of control.It is made by the extracting solution of following traditional Chinese medicines material: Radix Panacis Quinquefolii, Rhizoma Dioscoreae, Semen Nelumbinis, Fructus Alpiniae Oxyphyllae, Fructus Corni, Herba Pyrolae, Radix Astragali, Poria, Fructus Jujubae, the Radix Rehmanniae, the Radix Paeoniae Alba, Semen Ziziphi Spinosae, Radix Polygoni Multiflori Teng, Bulbus Lilii, Cortex Albiziae, Flos lupuli (Flos Humuli Lupuli), Os Draconis (calcined), river Rhizoma Coptidis, Herba Lophatheri, Flos Chrysanthemi, Rhizoma Acori Graminei, Fructus Crataegi.This medical instrument has kidney and spleen invigorating, tranquilizing by nourishing the heart, the effect of brain.Zoopery and clinical observation all show: characteristics such as it has evident in efficacy, safety to treatment neurasthenia and " preexam psychentonia syndrome ", and is nontoxic.

Description

The Chinese patent medicine of a kind of prevention and treatment neurasthenia and " preexam psychentonia syndrome "

The present invention is the neurasthenic Chinese patent medicine of a kind of control.

Clinical observation shows that in the face of nervous learning life and fierce examination hall competition, the people knows from experience, and a series of psychology, physiological change take place, because the difference of individual mind, body constitution.Quite a few examinee suffers from neurasthenia or appearance " tension syndrome before the examination ", and the clinical manifestation of above-mentioned disease is a psychentonia, fatigue and asthenia, hypomnesis, dizziness and tinnitus, insomnia and dreamful sleep, cardiopalmus, inappetence etc.In intellectual and scientific and technical personnel, because long-term heavy mental work, excessive thinking also has numerous patients that suffer from above-mentioned disease.In prior art, above-mentioned disease is not found gratifying therapy and medicine as yet, often treat clinically at present with the sedative hypnotic, and this type of medicine has and causes drowsiness, dizzy, the weak effect of paying, and for a long time with producing toleration, habituation and addiction.Therefore, press for a kind of medicine that can effectively prevent and treat above-mentioned disease and have no adverse reaction in the society, to remove numerous examinees and highbrow misery.

The objective of the invention is can effectively prevent and treat neurasthenia and " tension syndrome before the examination " for the demand that satisfies society provides a kind of, and Chinese patent medicine nontoxic, pair effect.

Theory of Chinese medical science is thought: anxiety impairing the spleen, and excessive thinking then causes deficiency of heart-blood, deficiency-weakness of spleen-QI in other words, and insufficiency of the spleen biochemistry is passive, deficiency of heart-blood, then gods are lost and are supported irritability.Deficiency-weakness of spleen-QI causes the kidney essense loss again thereupon, and the kidney master gives birth to marrow, leads in brain, the brain being the reservoir of the marrow, so the kidney essense loss, it is foster that brain is become homeless, thereby a series of above-mentioned clinical manifestations occur.Therefore, the inventor thinks: deficiency-weakness of spleen-QI, deficiency of heart-blood, kidney essense loss are neurasthenia, the main pathogenesis of tension syndrome before the examination.At above-mentioned pathogenesis, the present invention is the Therapeutic Principle with the kidney invigorating and essence nourishing, invigorating spleen and nourishing heart, and body and mind is nursed one's health.

Concrete therapeutic regimen of the present invention is as follows: this Chinese patent medicine is made (% meter by weight) by the extracting solution of following traditional Chinese medicines material:

Radix Panacis Quinquefolii 4% Rhizoma Dioscoreae 6% Semen Nelumbinis 4% Fructus Alpiniae Oxyphyllae 6%

Fructus Corni 4% Herba Pyrolae 4% Radix Astragali 6% Poria 4%

Fructus Jujubae 2% Radix Rehmanniae 4% Radix Paeoniae Alba 4% Semen Ziziphi Spinosae 4%

Shou Wu Tie-up 3% Bulbus Lilii 4% Cortex Albiziae 3% Flos lupuli (Flos Humuli Lupuli) 2%

Os Draconis (calcined) 13% river Rhizoma Coptidis 2% Herba Lophatheri 2% Flos Chrysanthemi 2%

Rhizoma Acori Graminei 6% Fructus Crataegi 10%

Radix Panacis Quinquefolii in the such scheme has yin nourishing, promotes the production of body fluid, the effect of clear asthenic fire, heat clearing away and restlessness relieving.Modern study shows that the effective constituent that mainly contains of Radix Panacis Quinquefolii is the ginsenoside.Its pharmacological evaluation proves that it can strengthen corticocerebral excitement and process of inhibition, improves neururgic motility; Can improve body mental work and blue-collar efficient, significant antifatigue effect is arranged; Can regulate vegetative nerve function; Enhancing immunity; Improve the defence capability of body to multiple destructive stimulus.Compare with Radix Ginseng, Radix Panacis Quinquefolii is mended and not dry, so elect it as principal agent.The all medicines of in the such scheme all the other are all accessory drugs, and wherein Rhizoma Dioscoreae, Semen Nelumbinis, Fructus Alpiniae Oxyphyllae have the effect of spleen reinforcing, supplementing the kidney to control the nocturnal; The Fructus Corni liver and kidney tonifying, the arresting seminal emission arresting sweating; Herba Pyrolae kidney tonifying, tonify deficiency, and have the effect of heart tonifying, coronary artery dilating and blood pressure lowering; The Radix Astragali is important Qi-tonifying drug, has the effect of invigorating the spleen and replenishing QI, yang invigorating consolidating superficial resistance, and can strengthen and regulate body's immunity, and disease resistance enhancemen can promote organism metabolism, also has stronger resisting fatigue and strong effect; Poria, Fructus Jujubae invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart; The Radix Rehmanniae, Radix Paeoniae Alba YIN nourishing, nourish blood; Semen Ziziphi Spinosae, Radix Polygoni Multiflori Teng, Bulbus Lilii, Cortex Albiziae, Flos lupuli (Flos Humuli Lupuli), Os Draconis (calcined) mind calming, calmness, calm the nerves; Rhizoma Coptidis, Herba Lophatheri, Flos Chrysanthemi clearing heat and relieving fidgetness; Rhizoma Acori Graminei is had one's ideas straightened out, is good for the stomach, the Fructus Crataegi appetite-stimulating indigestion-relieving.Above-mentioned all medicines share, and play kidney and spleen invigorating altogether, tranquilizing by nourishing the heart, the effect of brain.

Example:

According in the prior art to drawing in above-mentioned Chinese crude drug and the chemical composition analysis data, the composition that has in the above-mentioned Chinese crude drug has compositions such as glycoside (as the Saponin in Radix Panacis Quinquefolii, the Rhizoma Dioscoreae, the paeoniflorin in the Radix Paeoniae Alba, the Fructus Corni glycoside in the Fructus Corni etc.), alkaloid salt (as berberine in the Rhizoma Coptidis etc.), aminoacid.Mentioned component is not only water-soluble but also be dissolved in alcohol, and precipitable in 60% ethanol of impurity such as the starch in the medical material, pectin, phlegmatic temperament.For keeping effective ingredient as much as possible, and reduce impurity, the present invention adopts existing decoction and alcohol sedimentation technique to prepare this Chinese patent medicine, and selects the electuary dosage form for use.Have preparation technology and be divided into following three steps:

1. extract: with preparing by weight percentage after the clean system of the Chinese crude drug in the such scheme, soak, decoct three times, merge extractive liquid, left standstill 12-24 hour, supernatant concentration to relative density 1.12-1.15(40 ℃ ±)

2. precipitate with ethanol: above-mentioned extraction concentrated solution adds ethanol precipitation.Add 95% ethanol the first time, makes medicinal liquid contain the alcohol amount and reach 60%, after stirring, left standstill 24 hours, gets supernatant liquid filtering.The precipitation part adds the ethanol of about 1 times of amount 60% again, after stirring, leaves standstill supernatant liquid filtering 24 hours.Merge filtrate twice, reclaim ethanol, continue to be concentrated into relative density 1.30-1.35(80 ℃ ±)

3. system granule: get above-mentioned extractum, add 3 times of amount Icing Sugar, 1 times of amount dextrin is adjusted humidity with 70% ethanol, stir, make soft material, granulate 70-80 ℃ of drying with the 12-14 mesh sieve, carry out granulate with 10 mesh sieves, the Fructus Citri Limoniae essence of adding 0.05%, sealing is 1-2 hour behind the mixing, and packing (every bag 10 grams) is promptly.

The present invention has carried out the zoopery of pharmacology, toxicology aspect.The experiment of pharmacology aspect has: this Chinese patent medicine is to the influence of mice study, memory ability; This Chinese patent medicine is to effect of immunologic function; This Chinese patent medicine is to the influence of mice digestive system; This Chinese patent medicine is to the test of mouse anti-reflecting fatigue effect.The experiment of toxicology aspect has: acute toxicity testing, long term toxicity test.Above-mentioned result of experiment shows: this Chinese patent medicine safe, nontoxic has significant raising study, the ability of memory and the effect of enhancing human body immunity power, the function of improving digestive system and enhancing body anti-fatigue ability.

The present invention has carried out clinical observation.303 examples have been observed altogether.In 303 examples, be categorized as according to TCM Syndrome Type: deficiency of both the heart and spleen 180 examples, fire derived from stagnation of liver-QI type 35 examples, liver-kidney yin deficiency 88 examples, with deficiency of both the heart and spleen, liver-kidney yin deficiency for seeing more.Show that from the statistical result of observation table this Chinese patent medicine is best to the type of deficiency of both the heart and spleen curative effect, effective percentage is 97%; Liver-kidney yin deficiency takes second place, and effective percentage is 96%; Fire derived from stagnation of liver-QI type is relatively poor, and effective percentage is 66.7%.This shows that this Chinese patent medicine has the effect of invigorating the spleen and benefiting QI preferably, tonifying the kidney to consolidate the essence, nourishing the liver and kidney.In addition, take the variation of the every detection index in this Chinese patent medicine front and back from 303 examples, this Chinese patent medicine is to neurasthenia's (brain fag syndrome, should consider tension syndrome) due to multiple symptom significant improvement effect is all arranged, especially so that common symptons such as insomnia, spiritlessness and weakness, hypomnesis, uncomfortable in chest, inappetence are improved obviously.And blood pressure, RBC number, hemoglobin, leukocyte there is not influence.There simultaneously only have 2 examples to have in 303 examples to be slightly drowsiness, weak, disappears after four days, points out this Chinese patent medicine safety, nontoxic.

From the zoopery to the clinical observation, characteristics such as this Chinese patent drugs for treatment neurasthenia has evident in efficacy, safety, and is nontoxic have all been shown.

In sum, superiority of the present invention is that the paathogenic factor analysis is correct, and medication is accurate, nurse one's health proper, so evident in efficacy, be better than other similar medicine in the prior art, and do not have any poison, the effect of paying.

Claims (1)

1, the Chinese patent medicine of a kind of prevention and treatment neurasthenia and " tension syndrome before the examination " is characterized in that: the extracting solution by the following traditional Chinese medicines material is made (% meter by weight):

Radix Panacis Quinquefolii 4% Rhizoma Dioscoreae 6% Semen Nelumbinis 4% Fructus Alpiniae Oxyphyllae 6%

Fructus Corni 4% Herba Pyrolae 4% Radix Astragali 6% Poria 4%

Fructus Jujubae 2% Radix Rehmanniae 4% Radix Paeoniae Alba 4% Semen Ziziphi Spinosae 4%

Radix Polygoni Multiflori Teng 3% Bulbus Lilii 4% Cortex Albiziae 3% Flos lupuli (Flos Humuli Lupuli) 2%

Os Draconis (calcined) 13% river Rhizoma Coptidis 2% Herba Lophatheri 2% Flos Chrysanthemi 2%

Rhizoma Acori Graminei 6% Fructus Crataegi 10%