CN109620745A - A kind of anti-oxidant and anti-facial essence composition just to decline - Google Patents
A kind of anti-oxidant and anti-facial essence composition just to decline Download PDFInfo
- Publication number
- CN109620745A CN109620745A CN201811486412.5A CN201811486412A CN109620745A CN 109620745 A CN109620745 A CN 109620745A CN 201811486412 A CN201811486412 A CN 201811486412A CN 109620745 A CN109620745 A CN 109620745A
- Authority
- CN
- China
- Prior art keywords
- skin
- oxidant
- decline
- essence composition
- facial essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8188—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bonds, and at least one being terminated by a bond to sulfur or by a hertocyclic ring containing sulfur; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of anti-oxidant and anti-facial essence compositions just to decline, including following mass percent component: polyalcohol 2-6%；Beta glucan 0.2%-5%；Film forming agent 0.12%-1.8%；Thicken suspending agent 0.05%-1%；Silicone oil 0.2%-10%；Emulsifier 2.5%-4.5%；Dipotassium glycyrrhizinate 0.02%-0.2%；Dehydroxanthan 0.1%-1%；D-pantothenyl aleohol 0.1%-1%；Caffeine silanol 0.1-5%；Niacinamide 1%-5%；Plankton extractions 0.1-3%；Allantoin 0.05%-0.2%.Composition of the invention can effectively delay senescence and repair because of time bring face skin problem.
Description
Technical field
The present invention relates to daily chemicals fields, and in particular to a kind of anti-oxidant and anti-facial essence composition just to decline.
Background technique
Requirement with the development and people of modern society to quality of life is continuously improved, people increasingly pursues details and
Beauty also increasingly focuses on face modification and skin management.The skin problem of time to time change also increasingly causes people
Attention, many people are finding and are going delay skin aging and relaxation and wrinkle problem, many functions by various means
Property cosmetics and cure U.S. means and also therefore develop rapidly.
Studies have shown that aging is generally since 25 years old or so, and accelerate with the increase at age.Aging course is related to being permitted
More internal and external factors, the most common endogenous Some Circulating Factors related with aging course are free radicals.It is filled in the environment of human survival
Denounce countless free radical, we are not exposed to all the time in the encirclement and attack of free radical.Scientists discovery damage
The free radical of evil human health is nearly all related with those stronger oxygen carriers of activity, they with these substances combining
Free radical is called active oxygen radical.Damage of the active oxygen radical to human body is actually a kind of oxidation process.Therefore, it to drop
The damage of low free radical from anti-oxidant it is necessary to doing.Aging often brings many skin problems, relaxation, recess or even sagging
The case where start to protrude, skin lacks flexibility, and temple start to be recessed, apple flesh start it is sagging, decree line deepen, face pine
It relaxes, facial fat is started to move down by gravity.With advancing age, the symptom of aging is gradually appeared.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-oxidant and anti-facial-care products just to decline, and the composition passes through various
Ingredient it is reasonably combined so that composition of the invention have endogenous neurogenesis skin just decline, it is exogenous anti-oxidant, resist freely
Base.To more preferably solve the problems, such as face skin.Product is grown with significant moisturizing by the collaboration collocation of moisturizer and grease
Effect is supported, so that lotion of the present invention has outstanding moisture feeling.
A kind of anti-oxidant and anti-facial essence composition just to decline, including following mass percent component:
Polyalcohol 2-6%；
Beta glucan 0.2%-5%；
Film forming agent 0.12%-1.8%；
Thicken suspending agent 0.05%-1%；
Silicone oil 0.2%-10%；
Emulsifier 2.5%-4.5%；
Dipotassium glycyrrhizinate 0.02%-0.2%；
Dehydroxanthan 0.1%-1%；
D-pantothenyl aleohol 0.1%-1%；
Caffeine silanol 0.1-5%；
Niacinamide 1%-5%；
Plankton extractions 0.1-3%；
Allantoin 0.05%-0.2%.
Beta glucan is the polysaccharide that immunity is improved in a kind of yeast cell wall, is excellent immunoactivator, Neng Gouti
The immunity of high skin itself has the effect of removing free radical, assists damaged tissues to accelerate to restore to generate cytokine, in sensitive flesh
There is unique bioactivity in terms of skin reparation.Application enhancing skin immunity of β -1, the 3- glucan in cosmetics, can increase
The power of regeneration of damaged skin cell improves the regeneration rate of cuticula, has the characteristic for helping wound to restore.Clinical research
Showing beta glucan also has significant anti-inflammatory, antiallergic activity, and can help to skin resist it is exogenous various mechanical and
Chemical stimulation.
Beta glucan increases epidermal growth factor (EGF) on aged skin and wrinkle skin, will promote collagen in skin
Albumen and elastin laminin increase, so as to improve skin appearance and wrinkle reduction.Lang Gehanshi in ultraviolet light Irradiation on Skin is thin
Born of the same parents are inhibited, and if in the sun, langerhans' cells quantity can greatly reduce for skin exposure for a long time, activity is reduced,
Weaken the defence immunocompetence of skin.And beta glucan is except itself having anti-sunlight function and in addition to can be reduced pain inflammation, it is also
Langerhans' cells can be promoted to be proliferated, the immunocompetence of skin can be enhanced.Basis in beta glucan energy activating immune system is thin
Born of the same parents --- macrophage, macrophage generates epidermal growth factor (EGF), to promote collagen necessary to wound healing
It generates, while angiogenesis factor (AF) can promote neovascularization necessary to wound healing.
There is promotion growth to external epidermal keratinocytes (HaCaT), by the pendant carboxylic group in molecular structure
Can also be anti-oxidant, free radical is removed, while compounding also with polyalcohol and have good anti-corrosion synergistic effect.
This substance of dipotassium glycyrrhizinate can function similarly to the effect of adrenal gland sebum hormone, and not any pair
Effect.It can inhibit the inflammatory reaction of skin, improving telangiectasis so that the redness of skin be allowed to be improved has antiallergic
Antiinflammation.
There are three hydroxyls for D-pantothenyl aleohol, and physiological activity is higher, is changed into pantothenic acid in skin panthenol, panthenol exists in the form of pantothenic acid
In in human body living tissue, it is the component of coacetylase key, plays a part of acetylization reaction carrier.Acetate is reacted with coacetylase
The acetate for generating activation is to show the bioactivity of vitamin necessary to lipid and the synthesis of daytime albumen.It can reinforce just
Normal skin hydration function, having improves dry, coarse, furfur, the antipruritic and relevant erythema effect for the treatment of multiple dermatosis.Reinforce
It can promote the normal keratinization of skin after skin barrier function external application, improve the tolerance of skin Surfactant.Mitigate
Discomfort caused by constituent-sensitive is as calcination, shouting pain, itch and tingling etc. in cosmetics.Help to mitigate allergic symptom, help
In wound healing.
Not only (derivative of caffeine and silanol) works caffeine silanol in terms of solving rouge, meanwhile, and in weight
Skin histology is built, real compact skin (derivative of alginic acid and silanol) is increased, and anti-inflammatory aspect works.
Niacinamide can increase glycosyl ceramide and sphingomyelin content significantly, and can enhance ammonia
Acid --- the activity of palmitoyl transferase, colleague can also increase the synthesis of free fatty acid.Niacinamide can pass through stimulation in a word
The overall process of ceramide synthesis and the activity of up-regulation serine transferase improve the barrier of the permeability of skin.
Studies have shown that topical application niacinamide increases cuticula ceramide and dissociates on human volunteer dry skin
The level of fatty acid, while cholesterol levels also tend to increase.The increase of lipid level between corneocyte, especially neural acyl
The increase of amine level can improve the impaired permeable barrier function of epidermis.
Further, polyalcohol include ethylene glycol, glycerol, propylene glycol, polyethylene glycol, 1,3-BDO, in polyglycereol
It is at least one.The skin of human body be it is weakly acidic, skin oil and fat removal causes to have dry skin too much, to destroy sebum film, one
Denier loses sebum film, and skin is highly susceptible to external injury.Feel to also bring along many negative impacts to using.In order to protect
Skin is not dried and mild use feeling, therefore needs that there is the polyalcohol of moisturizing and moisturizing effect to make an addition to facial-care product
In.
Further, thickening suspending agent includes ammonium acryloyldime-thyltaurate/VP copolymer.Thickening suspending agent has increasing
It is thick, it is suspending stabilized and other effects, the viscosity of system can be increased, while also improving the stability of system.
Further, film forming agent includes kayexalate, Sodium Hyaluronate and carboxymethylchitosan.Polyphenyl
Vinyl sulfonic acid sodium is a multi-functional polymer, has original application in hair care and skin care item.It can be formed it is transparent, have
The film of elasticity, and shunk when dry, electrostatic is guided rapidly.Its form a film also have high-temperature stability, be resistant to be more than
The high temperature of 300oC.It has strong anionic property, can help to reduce surface tension.In skin care item, its film forming characteristics makes
It has the function of compact skin, smooth wrinkle.Carboxymethylchitosan has good film forming.It is coated on skin table
Behind face, then can form the sugared film of one layer of biology by its extremely strong film forming can significantly improve skin epidermis water loss problem, right
Cuticula keeps moisture-keeping function, prevents from having dry skin.Pm2.5 pollutant and carbon particle can be isolated simultaneously, reduce pm2.5
Response to oxidative stress caused by pollutant and mitochondrial toxicity and reduction skin carbon particle attachment.
Hyaluronic acid is the bio-molecules being widely present in skin and other tissues, has fabulous moisture-keeping function,
It is known as ideal natural moisturizing factor in the world.It is the best object of the performance of keeping humidity used for cosmetic that finds in current nature
Matter.
Meanwhile hyaluronic acid is also one of the main matrix ingredient of application on human skin epidermis and corium, physiological function is to make
Moisture enters space between cells, and forms protein gel in conjunction with protein, and cell is sticked together, the cell generation brought into normal play
The effect of thanking is played and keeps cell moisture, protects cell not by the infringement of pathogen, accelerates to restore skin histology, improves wound and be cured
The effects of conjunction power of regeneration, reduction scar, strengthen immunity.
Hyaluronic acid can also improve skin growth condition, for dermal collagen and elastomer synthesis provide it is superior
The effect of skin-protecting face nursing is played in external environment, the supply of reinforced nutrition matter.Studies have shown that hyaluronic acid HA can be prevented carefully
The generation of some enzymes in born of the same parents, reduces the formation of free radical, is preventing free radical from destroying eucaryotic cell structure, generation lipid peroxidation and is drawing
Play senility of humanbody etc. to play an important role: there is low-molecular-weight hyaluronic acid anti-inflammatory, inhibition germ to generate, keep skin light
Clean effect；Suitable place is provided for cell Proliferation and differentiation, directly facilitate cell growth, differentiation, rebuild and repair etc..
Further, silicone oil includes polymethylsilsesquioxane, dimethiconol, the poly- methyl silicon of cetearyl
At least one of oxygen alkane.Silicone oil colorless and odorless is had the advantage that after adding silicone oil in cosmetics, does not influence final product
Appearance and fragrance；Using there is relaxation, extensibility is good；Hydrophobicity and slickness are good；It is non-stimulated to skin, property safe to the human body
It is high；Gas-premeable is good, does not interfere cutaneous respiration；Chemical stability is good, does not react with other cosmetic materials.In skin
Dimethicone is added in care article, cosmetics can be improved to the extensibility of skin, play the effect of protection skin；
At present silicone oil oneself become many cosmetics important component or auxiliary agent, silicone oil have many unique properties, be added makeup
Comfort can have been increased in product and assigned gloss.
Further, emulsifier includes hydrolecithin and sodium acrylate/dimethyl acrylamide sodium acyl taurine and different 16 carbon
Alkane, at least one of polysorbate -80.Hydrolecithin has human skin as a kind of excellent naturally occurring emulsifying agent
There is protective effect.It is the proper constituent of Skin Cell, plays important work in terms of cell metabolism and cell membrane permeability adjusting
With, and to skin, there are also certain physiological actions, increase the cholesterol level of skin, form one layer of skin screen in skin surface
Barrier repairs cuticula, reduces skin irritatin.Also there are moisture-keeping functions simultaneously, there is synergistic function with other raw materials.Propylene
Sour sodium/dimethyl acrylamide sodium acyl taurine and different hexadecane, polysorbate -80 and hydrolecithin collocation skin sense are soft, outside
It goes sightseeing bright.
Further, plankton extractions include coral algae extract.Coral algae is the plant of swimming being made of unicellular alga
Object, also referred to as microalgae.Have benefited from original morphology and pigment synthesis device, this coral algae can resist intense light irradiation.It enables it to
Suspend mode is kept when bad environments should not survive, but can be brought back to life when environment is suitable for.Plankton extractions can increase protease
The activity of body subunit promotes the protein renaturation of oxidation by stimulation thioredoxin and thioredoxin reductase, and maintains
Biobalance.Reinforce cellular hydration degree with extracellular exchange into the cell by increasing.Increase cell activity, has and dispel well
Wrinkle and anti-oxidation efficacy.
Above-mentioned technical proposal is applied, the present invention has the following technical effect that
1. the facial essence to decline at the beginning of one kind of the present invention is anti-oxidant and anti-can needle by the ratio and combination of heterogeneity
The problems such as just declining to facial free radical and face develops new local therapeutic formula.Caffeine silanol in formula and floating
Bio-extract is swum by stimulation thioredoxin and thioredoxin reductase, promotes the protein renaturation of oxidation, passes through increase
It is intracellular to reinforce cellular hydration degree with extracellular exchange, increase cell activity.Not only in solution rouge and elimination facial edema etc.
Aspect works, meanwhile, and skin histology is being rebuild, increase real compact skin and anti-inflammatory aspect works, has good anti-wrinkle and resist
Oxidation efficiency.A variety of skin problems caused by just declining are repaired, while protecting skin to reduce free radical and generating.
2. the facial essence to decline at the beginning of one kind of the present invention is anti-oxidant and anti-, by niacinamide, D-pantothenyl aleohol and β-Portugal are poly-
Sugared is reasonably combined, synergistic in formula.The generation that all kinds of ceramides in skin can be increased, the level in cuticula
Lower in atopic dermatitis and the skin of aging, plays a significant role in the stable state of epidermal barrier maintains.And it can be improved
The immunity of skin itself has the effect of removing free radical, assists damaged tissues to accelerate to restore to generate cytokine, in sensitive skin
Repairing aspect has unique bioactivity, enhances skin immunity, can increase the power of regeneration of damaged skin cell, improves cutin
The regeneration rate of layer has the characteristic for helping wound to restore.And can help to skin resist it is exogenous it is various mechanically and chemically
Stimulation promotes collagen and elastin laminin in skin to increase, so as to improve skin appearance and wrinkle reduction.
3. the facial essence to decline at the beginning of one kind of the present invention is anti-oxidant and anti-, passes through hyaluronic acid and polystyrolsulfon acid
Sodium and anti-inflammatory anti-sensitizer it is reasonably combined, supplement moisture of skin in all fields.Kayexalate, hyaluronic acid and carboxylic first
Base chitosan forms layer protecting film in skin surface, allows the cuticula constantly to dry out originally to suspend dehydration, stays
Time restores the barrier ability of oneself, and repairs the barrier being damaged in skin, and skin can be allowed to restore " intercellular lipid " rapidly
Ability, film forming characteristics make it have the function of compact skin, smooth wrinkle, and the production of some enzymes in cell can be prevented by coordinating synergy
It is raw, the formation of free radical is reduced, is preventing free radical from the side such as destroying eucaryotic cell structure, generating lipid peroxidation and cause senility of humanbody
Face plays an important role, promote cell growth, differentiation, rebuild and repair etc..
Detailed description of the invention
Fig. 1 is on volunteer 1- embodiment 1() under & embodiment 2() patch test results comparison diagram.
Fig. 2 is on volunteer 2- embodiment 1() under & embodiment 2() patch test results comparison diagram.
Fig. 3 is that volunteer 3- embodiment 1(is left) & embodiment 2(is right) patch test results comparison diagram.
Fig. 4 is on volunteer 4- embodiment 1() under & embodiment 2() patch test results comparison diagram.
Fig. 5 is on volunteer 5- embodiment 1() under & embodiment 2() patch test results comparison diagram.
Specific embodiment
Below in conjunction with specific embodiment, present invention is further described in detail.
Unless otherwise specified, all percentage, number and ratio are based on content poidometer relevant to ingredients listed,
It and does not therefore include the carrier or by-product being possibly comprised in commercially available raw material.
The following table 1 is 3 preferred embodiments of the present invention and 3 comparative examples
Table 1: the formula of embodiment and comparative example
Prepare above-mentioned 3 groups of embodiments and 4 groups of comparative examples the preparation method is as follows:
A phase substance is weighed to beaker, is uniformly mixed, is warming up to 80 DEG C, B phase substance is weighed to another beaker, heating
To 80 DEG C to uniform oily liquid；After A phase substance homogeneous to gel, B phase substance is poured into A and mixes 5 min of homogeneous；Stirring
Paddle stirring is stirred evenly to 40 DEG C hereinafter, sequentially add C phase substance, after sequentially add D phase substance, continue stirring cooling
To 30 DEG C hereinafter, stopping stirring.
Test purpose: instrument efficacy assessment is carried out the effect of to above-mentioned 8 compositions, human body evaluates two methods
Efficacy assessment is carried out, finally obtains the average result as shown in table 2.
Test process: arbitrarily selecting 320 volunteers, and after entering group, every group is 35 volunteers, selects arm
As test position, test position, which is tested first 2~3 days, to use any product (cosmetics or topical drug) for inside, and 1~3
Hour cannot contact water, and cuticula moisture content measuring project symmetrically randomly selects the survey of 4 points (interval 1cm) in test position
Region is tried, symmetrically longitudinally chooses the test zone of (interval 2cm), control in test position through epidermis fluid loss test item at 3 points
Area and sample area should all wherein side that is random and being uniformly present in sample totality left and right sides, check plot and sample area take a little
It should bilateral symmetry；
After screening group, subject needs unified clear water cleaning test position, wipes moisture with dry face tissue, is meeting
Sit quietly 10 min in the room of environmental requirement, during which cannot drink water and beverage.Test position exposure, is placed in test mode, is protected
It holds and loosens；
With the cuticula moisture content of Corneometer moisture measurement probe test subject check plot, sample area, each region
It is measured in parallel 2 times, is averaged as basic cuticula moisture content；
With Tewameter water loss probe test subject check plot, sample area through epidermis fluid loss, each area test
3 times, through epidermis fluid loss based on being averaged；
It uses sample: 0.018g sample being applied to sample area, is applied to and fully absorbs.Check plot is blank；
Efficacy test: the timing since the time for smearing sample measures the cuticula of sample area, check plot in 1h, 3h, 6h respectively
Moisture content, through epidermis fluid loss, each region of cuticula moisture content is measured in parallel 2 times, through each region of epidermis fluid loss
Measurement 3 times is respectively averaged as test cuticula moisture content value, test through epidermis dehydration magnitude, the same subject
Test must use same instrument be completed by the same tester, twice measurement between should clean test probe.
Test equipment and material:
Table 2: test equipment
| Instrument title | Model specification |
| Skinanalysis apparatus | CK MPA580 |
| Corneometer moisture measurement probe | Corneometer CM825 |
| Tewameter water loss probe | Tewameter TM300 |
Method for testing and analyzing: mean analysis, change rate analysis and T are examined.
Test result:
Table 3: the effect of embodiment and comparative example, assesses test result
Comparative example 1 does not add caffeine silanol, plankton extractions and beta glucan these antioxidant contents, Bu Nenghe
Other components infringement of the static free radical to cell membrane together, free radical excessively will also result in a series of vicious circle-inflammation
Disease, cell death or canceration, collagen follow the string-spot, wrinkle and small pox, and crossing polyradical can also be such that skin accelerates
Saccharifying allows skin to lose dark yellow and elastic.Antioxidant forms layer protecting film, while anti-oxidant resistance in skin surface
Free radical avoids injury of the extraneous factor to skin, inhibits the Apoptosis of response to oxidative stress induction, maintains the complete of cell membrane
It is whole to have the function of significant anti-oxidant, anti-aging with stable.And percutaneous water loss rate is effectively reduced, make the great guarantor of skin
It is wet.So the moisture content of comparative example 1 is substantially reduced, skin moisture content is substantially reduced, through epidermis average moisture turnover rate
Obviously increase.
Comparative example 2 does not add hydrolecithin, allantoin, dipotassium glycyrrhizinate, beta glucan and D-pantothenyl aleohol these anti-inflammatory
Anti-sensitizer, cannot be with other components together synergistic supplement lipid identical with composition epidermal permeability barrier, cannot be in skin
Skin reaches antiinflammation, these anti-inflammatory anti-sensitizers not only have anti-inflammatory performance in skin, there are also bacteriostatic activity use, can protect and
Skin is cured, protects it from the influence of daily tension, and accelerate the healing process of skin, and the shape that declines at the beginning of can obviously improve skin
Condition.So the moisture content of comparative example 2 is substantially reduced, also increased through epidermis average moisture turnover rate in short term.
Comparative example 3 does not add niacinamide, hyaluronic acid, carboxymethylchitosan and kayexalate, they
Can be synergistic in formula, the generation of ceramide in skin can be increased, and can play in the maintenance of the stable state of epidermal barrier
Important function, decline state at the beginning of improving skin, restores full state.Kayexalate, hyaluronic acid and carboxymethyl are deacetylated
Chitin has good film forming, after being coated on skin surface, then can form the sugared film of one layer of biology.By its it is extremely strong at
Film property can significantly improve skin epidermis water loss problem, and energy Stratum Corneum keeps moisture-keeping function, prevents from having dry skin, and resists outer
Portion's injury, coordinates synergistic antioxidant, also there is compact lifting to skin.So the moisture content of comparative example 3 is substantially reduced,
It is also being increased through epidermis average moisture turnover rate in short term.
Preferred embodiment 1 and embodiment 2.Chicken embryo test is carried out to embodiment, passes through human skin enclosed type patch test
Examine product to human skin potential risks.5 volunteers for meeting test request are recruited, in stipulated time visiting experiment
Room；In spot tester (10 slots), 5 slots are not added sample and do blank area, and in addition 5 dropwise addition samples, are attached to volunteer's inner forearm.
Spot tester is removed after 7 h, is observed test position dermoreaction after 30min, is judged skin irritatin grade.
Test result:
Table 4: dermoreaction rank table
Table 5: cosmetic skin patch test results
Specific test result is as Figure 1-Figure 5, and human skin patch test result is shown, for two embodiments, in 5 people0
There is adverse reaction in example, and skin wound repair is determined as negative reaction, grading system 0.So embodiment irritation on the skin
It is minimum.
Although description of this invention combination embodiments above carries out, those skilled in the art
Member can carry out many replacements based on the above contents, modifications and variations, be obvious.Therefore, all such substitutions,
Improvements and changes are included in the spirit and scope of appended claims.
Claims (7)
1. a kind of anti-oxidant and anti-facial essence composition just to decline, which is characterized in that including following mass percent component:
Polyalcohol 2-6%；
Beta glucan 0.2%-5%；
Film forming agent 0.12%-1.8%；
Thicken suspending agent 0.05%-1%；
Silicone oil 0.2%-10%；
Emulsifier 2.5%-4.5%；
Dipotassium glycyrrhizinate 0.02%-0.2%；
Dehydroxanthan 0.1%-1%；
D-pantothenyl aleohol 0.1%-1%；
Caffeine silanol 0.1-5%；
Niacinamide 1%-5%；
Plankton extractions 0.1-3%；
Allantoin 0.05%-0.2%.
2. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that described is polynary
Alcohol includes at least one of ethylene glycol, glycerol, propylene glycol, polyethylene glycol, 1,3-BDO, polyglycereol.
3. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that the thickening
Suspending agent includes ammonium acryloyldime-thyltaurate/VP copolymer.
4. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that the film forming
Agent includes kayexalate, Sodium Hyaluronate and carboxymethylchitosan.
5. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that the silicone oil
Including polymethylsilsesquioxane, dimethiconol, at least one of cetearyl methicone.
6. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that the emulsification
Agent includes hydrolecithin and sodium acrylate/dimethyl acrylamide sodium acyl taurine and different hexadecane, in polysorbate -80 extremely
Few one kind.
7. the according to claim 1 anti-oxidant and anti-facial essence composition just to decline, which is characterized in that described swims
Bio-extract includes coral algae extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811486412.5A CN109620745A (en) | 2018-12-06 | 2018-12-06 | A kind of anti-oxidant and anti-facial essence composition just to decline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811486412.5A CN109620745A (en) | 2018-12-06 | 2018-12-06 | A kind of anti-oxidant and anti-facial essence composition just to decline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109620745A true CN109620745A (en) | 2019-04-16 |
Family
ID=66071549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811486412.5A Pending CN109620745A (en) | 2018-12-06 | 2018-12-06 | A kind of anti-oxidant and anti-facial essence composition just to decline |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109620745A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2853254A1 (en) * | 2013-09-26 | 2015-04-01 | Symrise AG | A cosmetic composition for lightening skin and/or hair |
| CN107638331A (en) * | 2017-08-31 | 2018-01-30 | 澳宝化妆品（惠州）有限公司 | A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical |
| CN108261368A (en) * | 2018-02-09 | 2018-07-10 | 广州重生化妆品实业有限公司 | A kind of compound goes pouch gel and its preparation process |
| CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
-
2018
- 2018-12-06 CN CN201811486412.5A patent/CN109620745A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2853254A1 (en) * | 2013-09-26 | 2015-04-01 | Symrise AG | A cosmetic composition for lightening skin and/or hair |
| CN107638331A (en) * | 2017-08-31 | 2018-01-30 | 澳宝化妆品（惠州）有限公司 | A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical |
| CN108261368A (en) * | 2018-02-09 | 2018-07-10 | 广州重生化妆品实业有限公司 | A kind of compound goes pouch gel and its preparation process |
| CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
Non-Patent Citations (2)
| Title |
|---|
| 宝拉.培冈 等: "《美丽圣经：升级版》", 30 April 2017, 广西师范大学出版社 * |
| 王昌涛 等: "《化妆品植物添加剂的开发与应用》", 30 April 2013, 中国轻工业出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11752168B2 (en) | Methods of using cosmetic compositions comprising exopolysaccharides derived from microbial mats | |
| CN109620746A (en) | A kind of Calyx Hibisci Sabdariffae extract and its application in facial-care composition | |
| KR102044562B1 (en) | cosmetic compositions | |
| CN109730954A (en) | It is quick with town, releive, maintenance, the skin care item and preparation method thereof for improving sebum film effect | |
| JP2011516585A (en) | Skin care composition and method of use thereof | |
| CN107638331A (en) | A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical | |
| CN111067832A (en) | Facial care product for repairing sensitive skin and resisting premature senility | |
| CN105943491A (en) | Moistening and moisturizing essence and preparation method thereof | |
| BR112020026167A2 (en) | lactobacillus plantarum for skin care | |
| CN107296764B (en) | Cream and preparation method thereof | |
| EP1870094A1 (en) | Antiwrinkle agent | |
| WO2010145008A1 (en) | Use of skin care compositions comprising laminariacea extract for treatment of skin aging signs | |
| CN109953926A (en) | Five crease-resistant, Antiageing effect skin care item of dimension and preparation method thereof | |
| CN112137951A (en) | Silicone-oil-free transparent amino acid shampoo capable of strengthening hair and repairing scalp barrier and preparation method thereof | |
| KR20150120426A (en) | Cosmetic composition containing a brown alga extract, a yeast extract and ascorbic acid | |
| CN108392434A (en) | A kind of silk-extract and whitening spot-eliminating composition and preparation method containing it | |
| CN101766550A (en) | Combination of monosaccharides and ascorbic acid and its use in cosmetic | |
| CN109862875A (en) | A kind of active mixture | |
| JP2007262012A (en) | Hyaluronic acid production promoter, skin external preparation containing the hyaluronic acid production promoter, cosmetic, quasi drug, chapped skin ameliorating agent, and wrinkle ameliorating agent | |
| CN107468610A (en) | A kind of extraction product of rice bran shell and its application in facial-care | |
| CN113041172B (en) | Sebum membrane bionic composition for skin barrier repair, application thereof and cosmetics | |
| JP2007269636A (en) | Interleukin 6 production inhibitor | |
| CN109620745A (en) | A kind of anti-oxidant and anti-facial essence composition just to decline | |
| US10596095B2 (en) | Method for moisturizing skin using P-113 peptide | |
| WO2022232566A2 (en) | Collagen compositions and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190416 |
|
| RJ01 | Rejection of invention patent application after publication |