CN109608543A - 稳定的多抗原结合抗体 - Google Patents
稳定的多抗原结合抗体 Download PDFInfo
- Publication number
- CN109608543A CN109608543A CN201811254222.0A CN201811254222A CN109608543A CN 109608543 A CN109608543 A CN 109608543A CN 201811254222 A CN201811254222 A CN 201811254222A CN 109608543 A CN109608543 A CN 109608543A
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- CN
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- Prior art keywords
- xaa xaa
- antibody
- antigen binding
- binding antibody
- aho
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/626—Diabody or triabody
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
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- Otolaryngology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549482P | 2011-10-20 | 2011-10-20 | |
| US61/549,482 | 2011-10-20 | ||
| CN201280051247.5A CN103890005A (zh) | 2011-10-20 | 2012-10-19 | 稳定的多抗原结合抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280051247.5A Division CN103890005A (zh) | 2011-10-20 | 2012-10-19 | 稳定的多抗原结合抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109608543A true CN109608543A (zh) | 2019-04-12 |
Family
ID=47115743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811254222.0A Pending CN109608543A (zh) | 2011-10-20 | 2012-10-19 | 稳定的多抗原结合抗体 |
| CN201280051247.5A Pending CN103890005A (zh) | 2011-10-20 | 2012-10-19 | 稳定的多抗原结合抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280051247.5A Pending CN103890005A (zh) | 2011-10-20 | 2012-10-19 | 稳定的多抗原结合抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20130101586A1 (https=) |
| EP (2) | EP2768855B1 (https=) |
| JP (3) | JP2014533239A (https=) |
| KR (1) | KR20140082700A (https=) |
| CN (2) | CN109608543A (https=) |
| AR (1) | AR088403A1 (https=) |
| AU (1) | AU2012325232B2 (https=) |
| BR (1) | BR112014009030A2 (https=) |
| CA (1) | CA2850572A1 (https=) |
| ES (1) | ES2687245T3 (https=) |
| MX (1) | MX2014004521A (https=) |
| RU (2) | RU2018112861A (https=) |
| TW (1) | TWI577696B (https=) |
| UY (1) | UY34404A (https=) |
| WO (1) | WO2013056851A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| AU2011283694B2 (en) | 2010-07-29 | 2017-04-13 | Xencor, Inc. | Antibodies with modified isoelectric points |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
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| JP2014533239A (ja) | 2014-12-11 |
| BR112014009030A2 (pt) | 2017-09-12 |
| US20130101586A1 (en) | 2013-04-25 |
| RU2018112861A (ru) | 2019-03-04 |
| CA2850572A1 (en) | 2013-04-25 |
| CN103890005A (zh) | 2014-06-25 |
| JP2019104759A (ja) | 2019-06-27 |
| TWI577696B (zh) | 2017-04-11 |
| AU2012325232A8 (en) | 2014-06-26 |
| AR088403A1 (es) | 2014-05-28 |
| TW201323445A (zh) | 2013-06-16 |
| JP2017125066A (ja) | 2017-07-20 |
| RU2652886C2 (ru) | 2018-05-03 |
| WO2013056851A3 (en) | 2013-06-13 |
| EP3431495A1 (en) | 2019-01-23 |
| MX2014004521A (es) | 2014-05-28 |
| EP2768855A2 (en) | 2014-08-27 |
| US20200048336A1 (en) | 2020-02-13 |
| UY34404A (es) | 2013-05-31 |
| WO2013056851A2 (en) | 2013-04-25 |
| AU2012325232A1 (en) | 2014-06-05 |
| ES2687245T3 (es) | 2018-10-24 |
| AU2012325232B2 (en) | 2017-08-31 |
| EP2768855B1 (en) | 2018-06-13 |
| RU2018112861A3 (https=) | 2021-08-12 |
| RU2014120154A (ru) | 2015-11-27 |
| KR20140082700A (ko) | 2014-07-02 |
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