CN109568556B - 一种用于治疗脱发的中药组合物及洗发水 - Google Patents
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Abstract
本发明涉及洗护品领域,公开了一种用于治疗脱发的中药组合物及洗发水,中药组合物包括:当归20‑30份、丹参10‑20份、川芎10‑30份、首乌10‑20份、无患子4‑8份、桉叶2‑6份、薄荷4‑8份、桑叶4‑8份、生姜2‑6份、灵芝2‑6份、侧柏叶4‑8份、三七0.5‑2份、桑葚0.5‑2份。本发明的中药组合物以及洗发水具有出色的促生发效果,且对皮肤无刺激。
Description
技术领域
本发明涉及洗护品领域,尤其涉及一种用于治疗脱发的中药组合物及洗发水。
背景技术
脱发的相关记载最早见于《黄帝内经》,将脱发称为“发堕”、“发落”、“毛折”。晋代葛洪所著的《肘后备急方》中出现了“发秃”的名称。隋代巢元方所著《诸病源候论》强调毛发的生长需要肾气的推动和血液的濡养,并详细分析了脱发的病因,认为脱发多是肾精亏虚,阴血不足,毛发失养所致。至此脱发作为疾病被正式记录下来。
西方医学对脱发病因的探究尚不完全明确,目前认为脱发多与遗传、雄激素、内分泌、生活习惯和精神压力等因素有关。对于疾病的治疗多采用激素类药物,副作用较为明显,不易被患者接受。而中医治疗脱发从整体角度出发,通过将不同药性、功效的中药配伍组方,实现多成分、多靶点、多途径的协同治疗作用,其疗效确切、毒副作用小,因此更易被中国患者接受。因此有必要开发出一款新的用于资料脱发的新中药产品。
发明内容
为了解决上述技术问题,本发明提供了一种用于治疗脱发的中药组合物及洗发水,本发明的中药组合物以及洗发水具有出色的促生发效果,且对皮肤无刺激。
本发明的具体技术方案为:一种用于治疗脱发的中药组合物,包括以下重量份的原料:当归20-30份、丹参10-20份、川芎10-30份、首乌10-20份、无患子4-8份、桉叶2-6份、薄荷4-8份、桑叶4-8份、生姜2-6份、灵芝2-6份、侧柏叶4-8份、三七0.5-2份、桑葚0.5-2份。
中医理论认为脱发的病因多为精血不足、痰湿、瘀血和血热,其疾病属性多为“虚实夹杂,本虚标实”。湿热、瘀血和热邪影响脏腑功能,导致肝不藏血、肾不藏精,气、血、精生化乏源,不能濡养毛发而致毛发脱落。本方是老中医整理历代中医古籍后经过长期临床试验并加以改良得到的经验方。通过对治疗脱发方剂的中药类别、药性、药味、归经进行整理总结,本脱发方剂配伍以补虚药为主导,与疾病“本虚”的属性一致,再配伍活血化瘀药、解表药、清热药、止血药等祛除“标实”之症。体现出补其虚损,去其实邪的治则治法。
补虚药首乌、当归、桑葚。首乌为补肾填精、平补阴血之良药。脱发多为慢性疾病,病程日久难免耗伤脏腑精气,何首乌既可补益肝肾,又可养血滋阴,使得肾精充足,毛发健旺,肝血充盈,须发荣润光泽。当归其补血与活血并行,一方面可以补血,血脉充盈则脏腑皮毛得养,头发光泽不易脱落;另一方面可以活血,使血行通畅,不形成瘀阻,毛发得以濡养,发根牢固,新发得生。桑葚可滋阴补血,生津润燥,通过补益肾气治疗阴血亏虚的须发早白。当归、何首乌、桑葚合用,不仅能够滋养肝肾、益精养血,还可补血行血,使得精血化生之源充足,流行之势通畅。可固其本源,滋其泉源,使头发生之有根,茂之有源。
活血化瘀药川芎、丹参辅灵芝。川芎为血中之气药,虽入血分,又能去一切风,调一切气。补新血祛瘀血助血行,同时,川芎可清热润燥,祛风养血,血中燥邪得祛,阴血得养,则毛发强健。丹参为临床常用活血药物,脱发患者湿热内蕴瘀阻经络、脉道,或肝气郁结瘀血阻滞之症,都可取丹参活血祛瘀之功效,使经络、脉道通畅,毛发得以润养,而不易脱落。灵芝具有补中益气、扶正固本、滋阴强壮之功效,可用于气血亏损引起的神疲体倦、腰虚酸软、脱发等症。已有研究证实灵芝孢子可加速患部血液循环,增强皮肤新陈代谢。灵芝配伍活血化瘀药川芎、丹参可滋阴血、活血化瘀以固发生发。
解表药薄荷、桑叶、生姜。《素问·痿论》:“肺热者,色白而毛败。”头面疾病多与风邪有关,风邪上犯扰动发根,不得濡养致毛发脱落。《医宗金鉴·油风》:“毛孔开张,邪风乘虚袭入,以致风盛燥血,不能荣养毛发。解表药物多具有祛除风邪之力,薄荷发散风热,可循经上至头目。桑叶乃手足阳明之药,可明目,长发。生姜味辛,能散、能行,可发散、行气、行血,用于治疗表证,而脱发即为表证,故姜可到达病所,可助其行气以利于血液运行,血行通畅则脱发得以改善。
止血药三七、侧柏叶。三七味甘苦、性温,为外科圣药,可化瘀止血,具有活血和养血双向调节功能,可扩张血管,改善头皮微环境,促进毛囊复苏,育发防脱。侧柏叶苦涩,微寒,除凉血止血功效外,历代医家多将其用于治疗须发疾病的方剂中。《日华子》中记载:“烧取汁,涂头,黑润鬓发。”为生发乌发良药。
清热解毒药无患子,拔毒生肌药桉叶。中医认为湿热上蒸、血热风燥会导致发蛀脱发,又称“蛀发癣”,即西医的脂溢性脱发。其病因与雄性激素及局部合并的细菌和真菌感染有关,发根细菌产生的溶解酶会导致毛囊萎缩、坏死而加重脂溢性脱发。无患子具有清热解毒、杀虫之功效,可抗菌、杀虫、治癣疾。无患子皂苷是天然表面活性剂,可清除皮肤油脂,同时具有抑菌、去屑、防脱发、滋润皮肤的功效。桉叶辛凉解表,清热解毒,其挥发油具有杀虫止痒、抗菌消炎、促进透皮吸收的作用。本方配伍无患子、桉叶以清热凉血燥湿,杀虫抗菌,养发生发。
由上配伍机理可知,本发明药方中的各味药之间能够实现互补,当上述特定原料配伍后能够起到较好的协同起效,缺一不可。
作为优选,配方包括以下重量份的原料:当归20-25份、丹参15-20份、川芎10-20份、首乌10-15份、无患子5-7份、桉叶3-6份、薄荷5-7份、桑叶5-7份、生姜3-5份、灵芝3-5份、侧柏叶4-6份、三七1-2份、桑葚1-2份。
最优选地,配方包括以下重量份的原料:当归20份、丹参20份、川芎10份、首乌10份、无患子6份、桉叶6份、薄荷5份、桑叶5份、生姜5份、灵芝5份、侧柏叶4份、三七2份、桑葚2份。
一种中药组合物的制备方法,包括以下步骤:
1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉,加水,浸泡,提取挥发油,收集轻、重挥发油备用,水液滤过备用,药渣备用;
2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉,与步骤1)中的药渣混合,加入乙醇溶液,浸泡,加热回流提取,滤过,将提取液浓缩至无乙醇味,与步骤1)中水液合并,过大孔树脂柱,以水洗脱,再以乙醇溶液洗脱,收集洗脱液备用;
3)将灵芝、三七药材粉碎为中粉,加入水,浸泡,加热回流提取,滤过,水液备用;
4)取步骤2)中所得的洗脱液与步骤3)中的水液合并,减压浓缩,得中药组合物。
在本发明制备方法中,需要严格进行分批制备,其中步骤(1)中的药材都含有挥发油,所以先提挥发油,水液含有水溶性成分备用,药渣再和步骤(2)中的药材混合后一起用乙醇提脂溶性成分。浓缩后过大孔树脂柱以水洗脱除去糖类、蛋白质等杂质。而步骤(3)中灵芝和三七都是难提取的药材,需要浸泡时间长,其有效成分也是水溶性,因此需要水提。
作为优选,所述粗粉为可全部通过二号筛且不超过40%可通过四号筛;所述中粉为可全部通过四号筛且不超过60%可通过五号筛。
作为优选,步骤1)中,加入与药材重量比为5-10倍量的水,浸泡2-3小时,提取挥发油1-2次,每次2-5小时。
作为优选,步骤2)中,加入与药材重量比5-10倍量、浓度为60-70wt%的乙醇溶液,浸泡2-3小时,加热回流提取2次,每次1-3小时;过大孔树脂柱时,以水洗脱2-4倍柱体积,再以70-90wt%的乙醇溶液洗脱。
作为优选,步骤3)中,加入与药材重量比5-10倍量的水,浸泡2-3小时,加热回流提取3次,每次2-3小时。
作为优选,步骤4)中,减压浓缩至总体积的1/8至1/10。
可将上述中药组合物作为洗发水的组分之一。
优选地,一种洗发水,包括以下质量百分数的原料:
中药组合物 5-10%,
挥发油重油 0.1-1%,
挥发油轻油 0.1-1%,
甘油 1-5%,
月桂醇聚醚硫酸酯钠 10-20%,
椰油酰谷氨酸钠 10-20%,
椰油酰胺丙基甜菜碱 3-8%,
椰油酰两性基乙酸钠 3-8%,
羟丙基瓜尔胶羟丙基三甲基氯化铵 0.1-2%,
椰油酰胺DEA 0.2-1%,
EDTA二钠 0.05-0.2%,
水余量至 100%。
一种洗发水的制备方法,包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至50-60℃加入中药组合物和混合液B,搅拌均匀,得到混合液D;
⑤将混合液D降温至40-45℃加入甘油和混合液C,搅拌均匀,制得成品。
在洗发水制备过程中,需要注意的是在步骤④中,中药组合物和混合液B在高温下易变化,因此需要在50-60℃左右加入;在步骤⑤中,由于混合液C易挥发,因此需要在40-45℃左右加入。
作为优选,步骤①、④、⑤中,搅拌速率为20-30rpm,搅拌时间20-30min。
与现有技术对比,本发明的有益效果是:本发明的中药组合物以及洗发水具有出色的促生发效果,且对皮肤无刺激,为脱发者提供了一种新的选择。
而与章光101育发剂相比,由于章光101育发剂配方中主要溶剂是乙醇,对皮肤有一定刺激性。使用时需要清洁头部后涂抹在头皮上,每天使用两次,每次3-10mL,使用不便。本发明产品为洗发水,可在每天洗头时使用,无需另外涂抹,使用更方便,且不含乙醇等刺激性溶剂。
附图说明
图1为实施例1中对照组实验第1、8、14天小鼠背部皮肤照片;
图2为实施例1中101组实验第1、8、14天小鼠背部皮肤照片;
图3为实施例1中洗发水组实验第1、8、14天小鼠背部皮肤照片;
图4为实施例1中各组小鼠背部皮肤HE染色情况图。
具体实施方式
下面结合实施例对本发明作进一步的描述。
总实施例一种用于治疗脱发的中药组合物,包括以下重量份的原料:当归20-30份、丹参10-20份、川芎10-30份、首乌10-20份、无患子4-8份、桉叶2-6份、薄荷4-8份、桑叶4-8份、生姜2-6份、灵芝2-6份、侧柏叶4-8份、三七0.5-2份、桑葚0.5-2份。
优选配方为:当归20-25份、丹参15-20份、川芎10-20份、首乌10-15份、无患子5-7份、桉叶3-6份、薄荷5-7份、桑叶5-7份、生姜3-5份、灵芝3-5份、侧柏叶4-6份、三七1-2份、桑葚1-2份。
一种上述中药组合物的制备方法,括以下步骤:
1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉,加入与药材重量比为5-10倍量的水,浸泡2-3小时,采用可同时提取轻、重挥发油的提取器(专利号:ZL201510038567.2)提取挥发油1-2次,每次2-5小时,收集轻、重挥发油备用,水液滤过备用,药渣备用;
2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉,与步骤1)中的药渣混合,加入与药材重量比5-10倍量、浓度为60-70wt%的乙醇溶液,浸泡2-3小时,加热回流提取2次,每次1-3小时,滤过,将提取液浓缩至无乙醇味,与步骤1)中水液合并,过大孔树脂柱,以水洗脱2-4倍柱体积,再以70-90wt%的乙醇溶液洗脱,收集洗脱液备用;
3)将灵芝、三七药材粉碎为中粉,加入与药材重量比5-10倍量的水,浸泡2-3小时,加热回流提取3次,每次2-3小时,滤过,水液备用;
4)取步骤2)中所得的洗脱液与步骤3)中的水液合并,减压浓缩至总体积的1/8至1/10,得中药组合物。
其中,所述粗粉为可全部通过二号筛且不超过40%可通过四号筛;所述中粉为可全部通过四号筛且不超过60%可通过五号筛。
一种洗发水,包括以下质量百分数的原料:
中药组合物 5-10%,
挥发油重油 0.1-1%,
挥发油轻油 0.1-1%,
甘油 1-5%,
月桂醇聚醚硫酸酯钠 10-20%,
椰油酰谷氨酸钠 10-20%,
椰油酰胺丙基甜菜碱 3-8%,
椰油酰两性基乙酸钠 3-8%,
羟丙基瓜尔胶羟丙基三甲基氯化铵 0.1-2%,
椰油酰胺DEA 0.2-1%,
EDTA二钠 0.05-0.2%,
水余量至 100%。
所述洗发水的制备方法包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至50-60℃加入中药组合物和混合液B,20-30rpm搅拌20-30min,得到混合液D;
⑤将混合液D降温至40-45℃加入甘油和混合液C,20-30rpm搅拌20-30min,制得成品。
实施例1
一种用于治疗脱发的中药组合物,包括以下重量份的原料:当归20份、丹参20份、川芎10份、首乌10份、无患子6份、桉叶6份、薄荷5份、桑叶5份、生姜5份、灵芝5份、侧柏叶4份、三七2份、桑葚2份。
制备方法为:
(1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉(能全部通过二号筛,但混有能通过四号筛不超过40%的粉末),加入与药材重量比为7.5倍量的水,浸泡2.5小时,采用可同时提取轻、重挥发油的提取器(专利号:ZL201510038567.2)提取挥发油2次,每次3.5小时,收集轻、重挥发油备用。水液滤过备用。药渣备用。
(2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉(能全部通过二号筛,但混有能通过四号筛不超过40%的粉末),与(1)中的药渣混合,加入与药材重量比7.5倍量、浓度为65%的乙醇,浸泡2.5小时,加热回流提取2次,每次2小时,滤过,乙醇提取液浓缩至无乙醇味,与(1)中水液合并,过大孔树脂柱,以水洗脱3倍柱体积,再以80%的乙醇洗脱,收集乙醇洗脱液备用。
(3)将灵芝、三七药材粉碎为中粉(指能全部通过四号筛,但混有能通过五号筛不超过60%的粉末),加入与药材重量比7.5倍量的水,浸泡2.5小时,加热回流提取3次,每次2.5小时,滤过,水液备用。
(4)取(2)中乙醇洗脱液与(3)中的水液合并,减压浓缩至总体积的1/9,得中药组合物。
一种洗发水,包括以下质量百分数的原料:
中药组合物 6%,
挥发油重油 0.5%,
挥发油轻油 0.5%,
甘油 2%,
月桂醇聚醚硫酸酯钠 14%,
椰油酰谷氨酸钠 12%,
椰油酰胺丙基甜菜碱 4%,
椰油酰两性基乙酸钠 5%,
羟丙基瓜尔胶羟丙基三甲基氯化铵 0.2%,
椰油酰胺DEA 1%,
EDTA二钠 0.1%,
水余量至 100%。
所述洗发水的制备方法包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至55℃加入中药组合物和混合液B,25rpm搅拌25min,得到混合液D;⑤将混合液D降温至42.5℃加入甘油和混合液C,25rpm搅拌25min,制得成品。
效果评价
(1)实验动物:21只近交系C57BL/6小鼠(上海斯莱克实验动物有限责任公司,合格证号2015000564635,雌性,6-8周)。
(2)实验方法:小鼠经乙醚麻醉后,采用松香/石蜡混合物(1∶1)脱毛法于小鼠背部制造面积约2cm×2cm的脱毛区。脱毛次日,将小鼠按随机排列表法分为:对照组(超纯水)、阳性对照组(章光101育发液)和中药洗发水组,每组7只,分别于脱毛区涂抹超纯水、章光101育发液、中药洗发水,每日2次,每次0.2mL/只,连续涂抹17天。
涂药后每天观察小鼠皮肤及毛色变化,记录每只小鼠背部去毛区的皮肤颜色从涂药到开始变黑的时间,从开始变黑到长满毛的时间。给药后第18天,将小鼠处死,取相同脱毛区皮肤,10%甲醛溶液固定,脱水,石蜡包埋切片,苏木精-伊红(HE)染色,显微镜下观察并统计小鼠皮肤毛囊数量(每例统计3个高倍视野内毛囊总数,10×20倍)。
实验结果
小鼠脱毛后,皮肤呈现粉红色,毛发进入休止期,涂药6~8天,101组和中药洗发水组小鼠皮肤开始发黑,8天后蒸馏水对照组开始变黑(分别如图1-3所示,由左至右分别为实验第1、8、14天各组小鼠背部皮肤照片;其中图1为对照组;图2为101组;图3为洗发水组),统计结果表明,与蒸馏水对照组比较,101组和中药洗发水组均可显著缩短C57BL/6小鼠脱毛后皮肤颜色由粉红变黑的时间,还可显著缩短皮肤由黑到长出毛的时间。洗发水组与101组比较皮肤由粉到黑时间、由黑到长出毛时间具有显著差异,结果见表l。
小鼠皮肤组织学检查结果表明,101组和洗发水组的毛囊数较对照组显著增加,结果见表2。
组别 | 皮肤由粉到黑时间(天) | 皮肤由黑到长出毛时间(天) |
对照组 | 8.2±0.5 | 4.5±0.3 |
101组 | 7.1±0.5** | 3.8±0.4* |
洗发水组 | 6.1±0.9**<sup>#</sup> | 3.3±0.4*<sup>#</sup> |
注:与对照组相比,*P<0.05;**P<0.01;洗发水组与101组相比,#P<0.05。
组别 | 毛囊计数 |
对照组 | 32.0±4.0 |
101组 | 39.6±5.3* |
洗发水组 | 41.9±4.2* |
注:与对照组相比,*P<0.05
各组小鼠背部皮肤HE染色情况如图4所示,其中A为对照组,B为101组,C为洗发水组。
通过观察C57BL/6近交系小鼠给药后毛发生长周期的变化以及小鼠毛囊计数结果,反映出给药对C57BL/6近交系小鼠毛发生长周期的影响。实验结果表明,本发明研制的中药洗发水能明显缩短C57BL/6近交系小鼠毛发生长有休止期进入生长期以及毛发长出表皮的时间,中药洗发水的生发效果良好,且对皮肤无刺激。
章光101是国内生发知名品牌,在生毛发行业中市场对其认可度较高。在生毛发实验中,通常将其作为阳性对照组,用来观察实验组的功效。洗发水组与101组比较,皮肤由粉到黑时间、由黑到长出毛时间具有显著差异。本研究通过实验证明中药洗发水能诱导C57BL/6小鼠毛发生长,缩短从休止期进人生长期的时间,增加毛囊数目。
实施例2
一种用于治疗脱发的中药组合物,包括以下重量份的原料:当归20份、丹参15份、川芎20份、首乌10份、无患子7份、桉叶3份、薄荷4份、桑叶4份、生姜3份、灵芝3份、侧柏叶4份、三七1份、桑葚1份。一种上述中药组合物的制备方法,括以下步骤:
1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉,加入与药材重量比为5倍量的水,浸泡2小时,采用可同时提取轻、重挥发油的提取器(专利号:ZL201510038567.2)提取挥发油2次,每次2小时,收集轻、重挥发油备用,水液滤过备用,药渣备用;
2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉,与步骤1)中的药渣混合,加入与药材重量比5倍量、浓度为70wt%的乙醇溶液,浸泡2小时,加热回流提取2次,每次1小时,滤过,将提取液浓缩至无乙醇味,与步骤1)中水液合并,过大孔树脂柱,以水洗脱2倍柱体积,再以70wt%的乙醇溶液洗脱,收集洗脱液备用;
3)将灵芝、三七药材粉碎为中粉,加入与药材重量比5倍量的水,浸泡2小时,加热回流提取3次,每次2小时,滤过,水液备用;
4)取步骤2)中所得的洗脱液与步骤3)中的水液合并,减压浓缩至总体积的1/8,得中药组合物。
其中,所述粗粉为可全部通过二号筛且不超过40%可通过四号筛;所述中粉为可全部通过四号筛且不超过60%可通过五号筛。
一种洗发水,包括以下质量百分数的原料:
中药组合物 5%,
挥发油重油 1%,
挥发油轻油 0.1%,
甘油 5%,
月桂醇聚醚硫酸酯钠 15%,
椰油酰谷氨酸钠 20%,
椰油酰胺丙基甜菜碱 3%,
椰油酰两性基乙酸钠 8%,
羟丙基瓜尔胶羟丙基三甲基氯化铵 0.1%,
椰油酰胺DEA 1%,
EDTA二钠 0.05%,
水余量至 100%。
所述洗发水的制备方法包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至50℃加入中药组合物和混合液B,20rpm搅拌20min,得到混合液D;⑤将混合液D降温至40℃加入甘油和混合液C,20rpm搅拌20min,制得成品。
实施例3
一种用于治疗脱发的中药组合物,包括以下重量份的原料:当归25份、丹参15份、川芎10份、首乌15份、无患子7份、桉叶6份、薄荷7份、桑叶7份、生姜5份、灵芝5份、侧柏叶6份、三七2份、桑葚2份。一种上述中药组合物的制备方法,括以下步骤:
1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉,加入与药材重量比为10倍量的水,浸泡3小时,采用可同时提取轻、重挥发油的提取器(专利号:ZL201510038567.2)提取挥发油2次,每次5小时,收集轻、重挥发油备用,水液滤过备用,药渣备用;
2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉,与步骤1)中的药渣混合,加入与药材重量比10倍量、浓度为60wt%的乙醇溶液,浸泡3小时,加热回流提取2次,每次3小时,滤过,将提取液浓缩至无乙醇味,与步骤1)中水液合并,过大孔树脂柱,以水洗脱4倍柱体积,再以70wt%的乙醇溶液洗脱,收集洗脱液备用;
3)将灵芝、三七药材粉碎为中粉,加入与药材重量比10倍量的水,浸泡3小时,加热回流提取3次,每次3小时,滤过,水液备用;
4)取步骤2)中所得的洗脱液与步骤3)中的水液合并,减压浓缩至总体积的1/10,得中药组合物。
其中,所述粗粉为可全部通过二号筛且不超过40%可通过四号筛;所述中粉为可全部通过四号筛且不超过60%可通过五号筛。
一种洗发水,包括以下质量百分数的原料:
中药组合物 10%,
挥发油重油 0.1%,
挥发油轻油 1%,
甘油 5%,
月桂醇聚醚硫酸酯钠 15%,
椰油酰谷氨酸钠 20%,
椰油酰胺丙基甜菜碱 3%,
椰油酰两性基乙酸钠 8%,
羟丙基瓜尔胶羟丙基三甲基氯化铵 0.1%,
椰油酰胺DEA 1%,
EDTA二钠 0.05%,
水余量至 100%。
所述洗发水的制备方法包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至60℃加入中药组合物和混合液B,30rpm搅拌30min,得到混合液D;⑤将混合液D降温至45℃加入甘油和混合液C,30rpm搅拌30min,制得成品。
本发明中所用原料、设备,若无特别说明,均为本领域的常用原料、设备;本发明中所用方法,若无特别说明,均为本领域的常规方法。
以上所述,仅是本发明的较佳实施例,并非对本发明作任何限制,凡是根据本发明技术实质对以上实施例所作的任何简单修改、变更以及等效变换,均仍属于本发明技术方案的保护范围。
Claims (10)
1.一种用于治疗脱发的中药组合物,其特征在于由以下重量份的原料制成:当归20-30份、丹参10-20份、川芎10-30份、首乌10-20份、无患子4-8份、桉叶2-6份、薄荷4-8份、桑叶4-8份、生姜2-6份、灵芝2-6份、侧柏叶4-8份、三七0.5-2份、桑葚0.5-2份。
2.如权利要求1所述的一种用于治疗脱发的中药组合物,其特征在于由以下重量份的原料制成:当归20-25份、丹参15-20份、川芎10-20份、首乌10-15份、无患子5-7份、桉叶3-6份、薄荷5-7份、桑叶5-7份、生姜3-5份、灵芝3-5份、侧柏叶4-6份、三七1-2份、桑葚1-2份。
3.如权利要求2所述的一种用于治疗脱发的中药组合物,其特征在于由以下重量份的原料制成:当归20份、丹参20份、川芎10份、首乌10份、无患子6份、桉叶6份、薄荷5份、桑叶5份、生姜5份、灵芝5份、侧柏叶4份、三七2份、桑葚2份。
4.一种如权利要求1所述的中药组合物的制备方法,其特征在于包括以下步骤:
1)将当归、川芎、薄荷、侧柏叶、生姜、桉叶药材粉碎为粗粉,加水,浸泡,提取挥发油,收集轻、重挥发油备用,水液滤过备用,药渣备用;
2)将丹参、首乌、桑叶、无患子、桑葚药材粉碎为粗粉,与步骤1)中的药渣混合,加入乙醇溶液,浸泡,加热回流提取,滤过,将提取液浓缩至无乙醇味,与步骤1)中水液合并,过大孔树脂柱,以水洗脱,再以乙醇溶液洗脱,收集洗脱液备用;
3)将灵芝、三七药材粉碎为中粉,加入水,浸泡,加热回流提取,滤过,水液备用;
4)取步骤2)中所得的洗脱液与步骤3)中的水液合并,减压浓缩,得中药组合物。
5.如权利要求4所述的制备方法,其特征在于,所述粗粉为可全部通过二号筛且不超过40%可通过四号筛;所述中粉为可全部通过四号筛且不超过60%可通过五号筛。
6.如权利要求4所述的制备方法,其特征在于:
步骤1)中,加入与药材重量比为5-10倍量的水,浸泡2-3小时,提取挥发油1-2次,每次2-5小时;
步骤2)中,加入与药材重量比5-10倍量、浓度为60-70wt%的乙醇溶液,浸泡2-3小时,加热回流提取2次,每次1-3小时;过大孔树脂柱时,以水洗脱2-4倍柱体积,再以70-90wt%的乙醇溶液洗脱;
步骤3)中,加入与药材重量比5-10倍量的水,浸泡2-3小时,加热回流提取3次,每次2-3小时;
步骤4)中,减压浓缩至总体积的1/8至1/10。
7.一种包含由权利要求4所述制备方法获得的中药组合物的洗发水。
8.如权利要求7所述的洗发水,其特征在于包括以下质量百分数的原料:
由权利要求4所述制备方法获得的中药组合物5-10%,
权利要求4所述制备方法获得的挥发油重油0.1-1%,
权利要求4所述制备方法获得的挥发油轻油0.1-1%,
甘油1-5%,
月桂醇聚醚硫酸酯钠 10-20%,
椰油酰谷氨酸钠 10-20%,
椰油酰胺丙基甜菜碱 3-8%,
椰油酰两性基乙酸钠 3-8%,
羟丙基瓜尔胶羟丙基三甲基氯化铵0.1-2%,
椰油酰胺DEA 0.2-1%,
EDTA二钠0.05-0.2%,
水余量至100%。
9.一种如权利要求8所述洗发水的制备方法,其特征在于包括以下步骤:
①将水、月桂醇聚醚硫酸酯钠、羟丙基瓜尔胶羟丙基三甲基氯化铵、椰油酰胺DEA、EDTA二钠混合并加热至70-80℃,搅拌均匀,得到混合液A;
②将所述挥发油重油与椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠在室温下搅拌混合均匀,得到混合液B;
③将所述挥发油轻油与椰油酰谷氨酸钠在室温下搅拌混合均匀,得到混合液C;
④将混合液A降温至50-60℃加入所述中药组合物和混合液B,搅拌均匀,得到混合液D;
⑤将混合液D降温至40-45℃加入甘油和混合液C,搅拌均匀,制得成品。
10.如权利要求9所述的制备方法,其特征在于:步骤①、④、⑤中,搅拌速度为20-30rpm,搅拌时间20-30min。
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