CN105342908A - 一种缓解皱纹的积雪草中药美容抗皱膏及其制备方法 - Google Patents
一种缓解皱纹的积雪草中药美容抗皱膏及其制备方法 Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Abstract
本发明提供一种缓解皱纹的积雪草中药美容抗皱膏,包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。本发明能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。
Description
技术领域
本发明涉及含有来源于植物、动物或矿物组份的美容配制品,特别涉及一种缓解皱纹的积雪草中药美容抗皱膏及其制备方法。
背景技术
中药美容是在中医中药基础理论的指导下,通过使用美容中药内服或外用来恢复或提高机体的生理功能的一种方法。内服法从内部补益气血、调节脏腑功能,使人气血充沛,容光焕发。外用法是运用药物直接作用于体表局部,它利用药物的性能,使气血流动、经气畅通,以达到美容防衰的功效。与化学化妆品相比较,中药美容具有显著的特点与优势。一是中药美容与中医药融为一体,具有明显的功能性,其原理跟中医学一样,注重整体的调理,强调先调理内在,然后就会形之于外,因此,美容效果持久、稳定。二是以中医理论为指导,具有中医理论特征,如整体观念、辨证论治、药性理论、复方配伍,具有与现代化妆品不同的思路。三是具有纯天然性,中药在美容防晒方面较化学合成品具有独特和显著的优势,具有无毒、无害、不致癌等特点。
迄今为止总结出来的美容中药共300多种,美容药方近千种,其精华可为现代美容提供行之有效的天然药物疗法。当归、人参、白芷、薏苡仁、杏仁、桃仁、枸杞、黄柏、菊花、白附子、川芎、百合、丹参、芡实等都是较常用的美容中药。其中当归性温,味甘、辛。具有活血、补血的功效,能加快血液循环,营养皮肤,使皮肤健康红润。人参含有挥发油,人参皂苷,多糖,多种低分子肽氨基酸,B族维生素、维生素C等成分,能改善局部皮肤的血液循环,加强皮肤营养物质的供应,促进皮肤的新陈代谢,保持皮肤的光洁和滋润,因而可以起到延缓皮肤衰老的作用。
杏仁性温,味苦。能润泽皮、毛及通利气机,古人用杏仁加以炮制,每早空腹服食,久用有驻颜延年之功。珍珠自古至今一直是人们喜爱的护肤驻颜美容佳品,能使肌肤细腻,颜色红润,无皱纹。据传清代慈禧太后就常吞服珍珠粉以驻颜美容。淮山、莲子、百合、红枣均能健脾养胃,养血安神,使得肌肤润泽健美。红花、桃仁等活血化淤药有改善皮肤微循环作用,从而使人的气血充盛,容光焕发。三七、丹参能滋润和清洁皮肤,祛除皮肤黄褐斑和黑斑,抑制脂溢性皮炎,对皮肤有延缓衰老作用。应用中药进行美容,内服的有汤剂、散剂、膏剂、酒剂,以及美容药膳等。生活中药膳美容应用较多,其实这是基于中医“医食同源、药食同源”的理论,选用某些作用相关的药物和食物配制成食品,以达到美容和保健的双重功效。外用有洗、熏,以及面膜敷等,又以面膜应用较多。
积雪草,为多年生匍匐草本。别名:十八缺、崩大碗、马蹄草、雷公根、蚶壳草、铜钱草、老虎草、落得打等。生于阴湿荒地、村旁、路边、水沟边。茎伏地,节上生根。叶互生,叶柄长;叶片圆形或肾形,直径2~4厘米。清热利湿,消肿解毒。治痧气腹痛,暑泻,痢疾,湿热黄疸,砂淋,血淋,吐、衄、咳血,目赤,喉肿,风疹,疥癣,疔痈肿毒,跌打损伤。
药理作用:对中枢神经作用
其中所含的甙对小鼠、大鼠有镇静、安定作用,此作用主要是对中枢神经系统中的胆碱能系统的影响。醇提取物无镇痛作用。
对皮肤组织的作用
积雪草甙能治疗皮肤溃疡,如顽固性创伤、皮肤结核、麻风等。对小鼠,豚鼠、兔肌肉注射或皮下植入可促进皮肤生长,局部白细胞增多、结缔组织盘管网增生、粘液分泌增加、毛及尾的生长加速等。曾有报告用含积雪草0.25~1%醇提取物(含积雪草酸、积雪草甙)的乳霜剂(其中尚含胚胎的或年幼的牛、猪或羊皮肤、肝、脑的水醇提取物)治疗皮肤病,获良好效果。
美容作用
积雪草具有清热解毒,利湿消肿、滋补、消炎、镇定的作用。能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。既能促进表皮与真皮之间的密切连接,又能抑制脂肪细胞的增加,防止皮肤水肿、出现肥胖。
积雪草适用于各种肤质,其幼芽的水提取物具有抗菌消炎的作用,其属双子叶植物伞形科,能消肿解毒祛脓疮。
抗菌作用
幼芽的水提取物有抗菌作用。积雪草甙能治疗麻风,有人认为其作用为溶解细菌的蜡膜,从而被其他药物或机体防御机能所消灭。
其他作用
醇提取物能松弛大鼠离体回肠。甙部分能降低家兔及大鼠离体回肠的张力及收缩幅度,并能轻度抑制乙酰胆碱的作用。对麻醉犬,静脉注射可轻度兴奋呼吸,心率变慢及中度的降低血压,后二者不能被阿托品阻断。
发明内容
本发明所要解决的技术问题在于,中药美容是在中医中药基础理论的指导下,通过使用美容中药内服或外用来恢复或提高机体的生理功能的一种方法。内服法从内部补益气血、调节脏腑功能,使人气血充沛,容光焕发。外用法是运用药物直接作用于体表局部,它利用药物的性能,使气血流动、经气畅通,以达到美容防衰的功效。与化学化妆品相比较,中药美容具有显著的特点与优势。
为解决这些技术难题,本发明提供了一种缓解皱纹的积雪草中药美容抗皱膏,其所述中药抗皱膏中包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
所述缓解皱纹的积雪草中药美容抗皱膏,其所述中药抗皱膏中可以包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
所述缓解皱纹的积雪草中药美容抗皱膏,其所述中药抗皱膏中还可以包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
为解决上述技术问题,本发明还提供一种缓解皱纹的积雪草中药美容抗皱膏的制备方法,其所述制备方法包括以下步骤:
a.积雪草的制备,萃取,作为组分1;
b.取薄荷、三七、白芷与白芨用蒸馏法汽化成结晶,粉碎过细筛待用,作为组分2;
c.将其余原料药用乙醇提取2次,合并浓缩提取液,作为组分3;
d.将组分1、组分2与组分3混合后加基质调和,杀菌装罐。
所述步骤a中,取春夏季将采摘好的积雪草切碎,过80-100目筛。
所述步骤a中,进一步包括萃取的步骤是,将药粉置于有盖不锈钢桶内,加70%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置。加热浓缩至膏状,静置备用,成组分1。
所述步骤b中,可以取薄荷、三七、白芷与白芨用蒸馏法汽化成结晶,粉碎过120-150目细筛待用,作为组分2。
所述步骤c中,可以将所述其余原料加入占其质量5-10倍量的乙醇浸泡4-6小时,加热提取2次,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,再置入0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,作为组分3。
所述步骤d中,可以将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,成凝胶剂;所述基质选自:蜂胶、聚山梨酯-80、三乙醇胺、丙二醇,半合成脂肪酸甘油酯、泊洛沙姆、聚乙二醇、羊毛脂中的一种或多种。
为解决上述技术问题,本发明还提供一种缓解皱纹的积雪草中药美容抗皱膏的使用方法,使用的方法是:每次临睡前洁面后,将抗皱膏均匀涂抹于脸部,并用中指指肚在脸部按摩15-20分钟,至其充分吸收后,第二天早起洗去即可。
本发明参考古今中医学药理研究成就,筛选滋润肌肤、补气活血、清肝明目、滋肝补肾、明目退翳、平肝潜阳、消肿除水的天然中药,扶正祛邪,通腑泄毒,活血散瘀,调节人体的新陈代谢机能,提高人体脸部皮肤血液循环,从而达到去除皱纹,紧致肌肤,消除皮肤纹理,消肿祛瘀、缓解疲劳、紧致眼周肌肤、淡化眼袋,减少皱纹、美化容貌的目的。本发明能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。
具体实施方式
中药美容是在中医中药基础理论的指导下,通过使用美容中药内服或外用来恢复或提高机体的生理功能的一种方法。内服法从内部补益气血、调节脏腑功能,使人气血充沛,容光焕发。外用法是运用药物直接作用于体表局部,它利用药物的性能,使气血流动、经气畅通,以达到美容防衰的功效。与化学化妆品相比较,中药美容具有显著的特点与优势。一是中药美容与中医药融为一体,具有明显的功能性,其原理跟中医学一样,注重整体的调理,强调先调理内在,然后就会形之于外,因此,美容效果持久、稳定。二是以中医理论为指导,具有中医理论特征,如整体观念、辨证论治、药性理论、复方配伍,具有与现代化妆品不同的思路。三是具有纯天然性,中药在美容防晒方面较化学合成品具有独特和显著的优势,具有无毒、无害、不致癌等特点。
迄今为止总结出来的美容中药共300多种,美容药方近千种,其精华可为现代美容提供行之有效的天然药物疗法。当归、人参、白芷、薏苡仁、杏仁、桃仁、枸杞、黄柏、菊花、白附子、川芎、百合、丹参、芡实等都是较常用的美容中药。其中当归性温,味甘、辛。具有活血、补血的功效,能加快血液循环,营养皮肤,使皮肤健康红润。人参含有挥发油,人参皂苷,多糖,多种低分子肽氨基酸,B族维生素、维生素C等成分,能改善局部皮肤的血液循环,加强皮肤营养物质的供应,促进皮肤的新陈代谢,保持皮肤的光洁和滋润,因而可以起到延缓皮肤衰老的作用。
中医气血理论认为,气血循环过程是人体一切组织器官进行工作的物质基础,气血以流畅平衡为贵,如果气血不流畅就会产生瘀血,瘀血阻于体内,将进一步导致气血循环的恶化,造成更严重的瘀塞,故中医以气血为纲,通过调气活血使之流畅平衡,可祛病强身、养血美容。皮肤斑点之根本在瘀,退斑必先祛瘀、祛瘀当须活血,活血更须补气、理气,气为血之帅,血随之而运行;血为气之守,气得之而静谧,气结则血凝,气虚则血脱,气迫则血走。气血和则俱和。而理气在肝,补气在肺肾,肺主皮毛。因气滞血瘀,影响到肺脾肝肾的气血运行功能,而致面部出现黄褐斑、黑眼圈、眼袋、眼部浮肿、雀斑等色斑,甚至出现头发脱落、斑秃。
积雪草,为多年生匍匐草本。别名:十八缺、崩大碗、马蹄草、雷公根、蚶壳草、铜钱草、老虎草、落得打等。生于阴湿荒地、村旁、路边、水沟边。茎伏地,节上生根。叶互生,叶柄长;叶片圆形或肾形,直径2~4厘米。清热利湿,消肿解毒。治痧气腹痛,暑泻,痢疾,湿热黄疸,砂淋,血淋,吐、衄、咳血,目赤,喉肿,风疹,疥癣,疔痈肿毒,跌打损伤。
药理作用:对中枢神经作用
其中所含的甙对小鼠、大鼠有镇静、安定作用,此作用主要是对中枢神经系统中的胆碱能系统的影响。醇提取物无镇痛作用。
对皮肤组织的作用
积雪草甙能治疗皮肤溃疡,如顽固性创伤、皮肤结核、麻风等。对小鼠,豚鼠、兔肌肉注射或皮下植入可促进皮肤生长,局部白细胞增多、结缔组织盘管网增生、粘液分泌增加、毛及尾的生长加速等。曾有报告用含积雪草0.25~1%醇提取物(含积雪草酸、积雪草甙)的乳霜剂(其中尚含胚胎的或年幼的牛、猪或羊皮肤、肝、脑的水醇提取物)治疗皮肤病,获良好效果。
美容作用
积雪草具有清热解毒,利湿消肿、滋补、消炎、镇定的作用。能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。既能促进表皮与真皮之间的密切连接,又能抑制脂肪细胞的增加,防止皮肤水肿、出现肥胖。
积雪草适用于各种肤质,其幼芽的水提取物具有抗菌消炎的作用,其属双子叶植物伞形科,能消肿解毒祛脓疮。
黄芪以补虚为主,能补气固表,利尿托毒,排脓,敛疮生肌。用于气血不足、疮疡内陷、脓成不溃或久溃不敛者。黄芪具有很好的托毒生肌的功能,即久不愈合的脓肿化脓生肌。现代医学研究表明,黄芪内含而多种抗菌有效成分,而且能增强机体的免疫功能,因此还能用于预防某些传染病的发生。《本草逢原》载:“黄芪能补五脏诸虚,治脉弦自汗,泻阴火,去肺热,无汗则发,有汗则止。”是增进抵抗力和防御疾病的良药。
天竺葵止血,收缩血管,气喘,肝排毒,胆结石,肾排毒,肾结石,利尿,肌肉酸痛,油性皮肤,老化皮肤活化,疱疹,皮肤苍白,减肥,促进结疤,湿疹,灼伤晒伤,癣,月经不顺,乳房充血发炎,减轻忧郁不安,驱赶恶魔,补身,除臭,抗菌,杀菌,戒烟〔酒〕。天竺葵的主要功能在于调肤,天竺葵提取液中的有效成分与天然有机脂具有很强的亲和性,因此,天竺葵常与有机脂结合制成凝脂产品。一般的清洁用品在清洗过后,护肤的功能性成分大部分会被水冲洗流失,瑞士的科研人员在三高新鲜提取技术的基础上,通过添加择向活性酶等手段,使天竺葵的有效成分在与凝脂亲和的同时也与肌肤表皮层产生亲和性,这种亲和性超越了与水的亲和性,因此,在清洗的过程中,天竺葵的大部分有效成分仍能够被皮肤吸收,起到调肤的效果,天竺葵几乎适合各种皮肤状况,因为它能平衡皮脂分泌而使皮肤饱满。可能对湿疹、灼伤、带状疱疹、疱疹、癣及冻疮有益。对松垮、毛孔阻塞及油性皮肤也很好,由于天竺葵可以收缩毛孔,促进血液循环,使用后会让苍白的皮肤较为红润有活力,使皮肤亮泽细腻。
白芍入肝、脾经,养血柔肝,缓中止痛,敛阴收汗。治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下,妇人血闭不通,消瘀血,能蚀脓,益女子血。《日华子本草》:治风、补劳,主女人一切病,并产前后诸疾,通月水,退热,除烦,益气,天行热疾,瘟瘴,惊狂,妇人血运,及肠风,泻血,痔瘘。发背,疮疥,头痛,明目,目赤努肉。赤色者多补气,白者治血。
白芨性苦、甘、涩,微寒。归肺、肝、胃经。功能主治收敛止血,消肿生肌。用于咳血吐血,外伤出血,疮疡肿毒,皮肤皲裂;肺结核咳血,溃疡病出血。《神农本草经》:“主痈肿、恶疮、败疽,伤阴死肌,胃中邪气”;《本草纲目》:“气味(根)苦、平、无毒。
白芷性味归经:辛,温。归肺、胃经。祛风散寒,通窍止痛,消肿排脓,燥湿止带。《日华子本草》:治目赤胬肉,及补胎漏滑落,破宿血,补新血,乳痈、发背、瘰疬、肠风、痔瘘,排脓,疮痍、疥癣,止痛生肌,去面皯疵瘢。
丹参苦,微寒。归心、肝经。祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠。用于胸肋胁痛,风湿痹痛,症瘕结块,疮疡肿痛,跌仆伤痛,月经不调,经闭痛经,产后瘀痛等。治疗胸肋疼痛、症瘕结块,以及月经不调、经闭经痛具有良效。《纲目》载:丹参,按《妇人明理论》云,四物汤治妇人病,不问产前产后,经水多少,皆可通用,惟一味丹参散,主治与之相同。盖丹参能破宿血,补新血,安生胎,落死胎,止崩中滞下,调经脉。丹参主要成分丹参酮有扩张血管、改善循环、解除血管内凝血等作用,具有活血化痕之功效,并能促进肝脏血液循环,利于肝细胞再生。
金盏花,拉丁名(Calendulaofficinalis),又名金盏菊、常春花。金盏菊富含多种维生素,尤其是维生素A和维生素C,可预防色素沉淀、增进皮肤光泽与弹性、减缓衰老、避免肌肤松弛生皱。也可预防文明病,如血管病变及癌症,更能理气止咳、健胃、化痰、预防哮喘及支气管炎。几乎各部位都可以食用;其花瓣有美容之功能,花含类胡萝卜素、番茄烃、蝴蝶梅黄素、玉红黄质、挥发油、树脂、黏液质、苹果酸等。根含苦味质,山金东二醇;种子含甘油酯、蜡醇和生物碱。放入洗发精里可以使得头发颜色变淡。
薄荷,土名叫“银丹草”,为唇形科植物,即同属其他干燥全草,多生于山野湿地河旁,根茎横生地下,是一种有特种经济价值的芳香作物。全株青气芳香。叶对生,花小淡紫色,唇形,花后结暗紫棕色的小粒果。薄荷是中华常用中药之一。它是辛凉性发汗解热药,治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症。处用可治神经痛、皮肤瘙痒、皮疹和湿疹等。薄荷是中国常用中药,幼嫩茎尖可作菜食,全草又可入药,治感冒发热喉痛,头痛,目赤痛,肌肉疼痛,皮肤风疹搔痒,麻疹不透等症,此外对痈、疽、疥、癣、漆疮亦有效。薄荷含有薄荷醇,该物质可清新口气并具有多种药性,可缓解腹痛、胆囊问题如痉挛,还具有防腐杀菌、利尿、化痰、健胃和助消化等功效。大量食用薄荷可导致失眠,但小剂量食用却有助于睡眠。
红花(拉丁学名:CarthamustinctoriusL.),别名:红蓝花、刺红花,菊科、红花属植物,干燥的管状花,橙红色,花管狭细,先端5裂,裂片狭线形,花药黄色,联合成管,高出裂片之外,其中央有柱头露出。具特异香气,味微苦。以花片长、色鲜红、质柔软者为佳。活血通经,散瘀止痛,有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。有活血化瘀,散湿去肿的功效。
桃仁(SemenPersicae),可指桃核里的仁儿;作为中草药桃仁使用时,特指蔷薇科植物桃或山桃的种子,别名毛桃仁、扁桃仁、大桃仁,6~7月果实成熟时采摘,除去果肉及核壳,取出种子,晒干,有活血祛瘀、润肠通便的功效,可用于经闭、痛经、癓瘕痞块、跌扑损伤、肠燥便秘等。孕妇慎用。临床观察证明,桃仁对血流阻滞、血行障碍有改善作用,能使各脏器各组织机能恢复正常。
火棘果,火棘(Pyracanthafortuneana(Maxim.)Li),以果实、根、叶入药,性平,味甘、酸,叶能清热解毒,外敷治疮疡肿毒,火棘果实含有丰富的有机酸、蛋白质、氨基酸、维生素和多种矿质元素,可鲜食,也可加工成各种饮料。其果实秋季成熟,似火把,可作行道树或庭院栽植。其根皮、茎皮、果实含丰富的单宁,可用来提取鞣料。火棘根可入药,其性味苦涩,具有止泻、散瘀、消食等功效,果实、叶、茎皮也具类似药效。火棘树叶可制茶,具有清热解毒,生津止渴、收敛止泻的作用。红果中含有抑制龋齿的活性物质,对人类牙齿防治有积极意义,又是制作牙膏的优质原料。台湾红果红中透亮玲珑如珠,因味似苹果又被称为“袖珍苹果”,“微果之王”。一颗如珠的红果其维生素C的含量相当于一个大苹果,是营养极高的保健型水果。科学研究发现,红果中含有生物增白物质,能有效地抑制人体内各种色素酶的活力,使皮肤不产生色素。红果提取液被广泛用于化妆品中,富含天然火棘精华,能达肌肤底层,由内而外深层美白,保湿,有效改善暗沉干燥现象。
龙胆草清热燥湿;泻肝定惊。湿热黄疸;小便淋痛;阴肿阴痒;湿热带下;肝胆实火之头胀头痛;目赤肿痛;耳聋耳肿;胁痛口苦;热病惊风抽搐。《纲目》:疗咽喉痛,风热盗汗。相火寄在肝胆,有泻无补,故龙胆之益肝胆之气,正以其能泻肝胆之邪热也。但大苦大寒,过服恐伤胃中生发之气,反助火邪,亦久服黄连反从火化之义。《本草经疏》:草龙胆味既大苦,性复大寒,纯阴之药也,虽能除实热,胃虚血少之人不可轻试。空腹饵之令人溺不禁,以其太苦则下泄太甚故也。
玫瑰花中含有300多种化学成份,如芳香的醇、醛、脂肪酸、酚和含香精的油和脂,常食玫瑰制品中以柔肝醒胃,舒气活血,美容养颜,令人神爽。玫瑰初开的花朵及根可入药,有理气、活血、收敛等作用、主治月经不调,跌打损伤、肝气胃痛,乳臃肿痛等症。玫瑰果的果肉,可制成果酱,具有特殊风味,果实含有丰富的维生素C及维生素P,可预防急、慢性传染病、冠心病、肝病和阻止产生致癌物质等。用玫瑰花瓣以蒸馏法提炼而得的玫瑰精油(称玫瑰露),可活化男性荷尔蒙及精子。玫瑰露还可以改善皮肤质地,促进血液循环及新陈代谢。
益母草味辛苦、凉,活血、祛淤、调经、消水,治疗妇女月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血、泻血,痈肿疮疡。益母草有利尿消肿、收缩子宫作用的作用,是历代医家用来治疗妇科病的要药。益母草可全草入药,有效成分为益母草素,益母草含益母草碱、水苏碱、益母草定、益母草宁等多种生物碱及苯甲酸、氯化钾等。益母草制剂有兴奋动物子宫的作用,与脑垂体后叶素相似,益母草浸膏及煎剂对子宫有强而持久的兴奋作用,不但能增强其收缩力,同时能提高其紧张度和收缩率。
白蔹为葡萄科植物白蔹的根,每年春、秋季采挖,除去茎及细须根,洗净后多纵切成两瓣、四瓣或斜片,晒干即可入药。其性凉,味苦甘辛,具有清热、解毒、散结、生肌、止痛的功效,用于治疗痈肿、疔疮、瘰疬、烫伤、温疟、惊痫、血痢、肠风、痔漏等症。
人参自古誉为“百草之王”“滋阴补生,扶正固本”之极品,含多种皂甙和多糖类成分,浸出液可被皮肤缓慢吸收且无不良刺激,能扩张皮肤毛细血管,促进皮肤血液循环,增加皮肤营养,调节皮肤的水油平衡,防止皮肤脱水、硬化、起皱,人参活性物质抑制黑色素的还原性能,使皮肤洁白光滑,能增强皮肤弹性,使细胞获得新生,是护肤美容的极品。将人参直接浸入50%甘油,10日后甘油搓脸,或将人参煎成浓汁,每日往洗脸水倒一点,用含人参的甘油搓脸或人参水洗脸,能让皮肤相当滋润。
玉竹,学名:Polygonatumodoratum(Mill.)Druce,为百合科多年生草本植物。根茎横走,肉质黄白色,密生多数须根。玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质-洗胰清糖素(cics),具有降血糖、血脂、血压等作用。玉竹具养阴、润燥、清热、生津、止咳等功效。用作滋补药品,主治热病伤阴、虚热燥咳、心脏病、糖尿病、结核病等症,并可作高级滋补食品、佳肴和饮料,具有保健作用。
月季花花朵可提取香精,并可入药。也有较好的抗真菌及协同抗耐药真菌活性。花可提取香料。根、叶、花均可入药,具有活血消肿、消炎解毒功效。而且是一味妇科良药。中医认为,月季味甘、性温,入肝经有活血调经、消肿解毒之功效。由于月季花的祛瘀、行气、止痛作用明显,故常被用于治疗月经不调、痛经等病症。月经过多、白带多,用月季花(或根)15g水煎服或炖猪肉食;月季花10g、大枣12g同煎,汤成后加适量蜂蜜服用,此方又香又甜,不像是药,对经期潮热很有效。此外,女性常用月季花瓣泡水当茶饮,或加入其他健美茶中冲饮,还可活血美容,使人青春长驻。
地桃花为锦葵科梵天花属植物肖梵天花UrenalobataL.,以根和全草入药。甘,淡,平入心、肺经。祛风利湿,清热解毒。感冒发热,风湿痹痛,痢疾,水肿,白带,吐血,痈肿,外伤出血,毒蛇咬伤,急惊风,破伤风,哮喘,胃痛产后风。祛风活血,清热利湿,解毒消肿。根:用于风湿关节痛,感冒,疟疾,肠炎,痢疾,小儿消化不良,白带。全草:外用治跌打损伤,骨折,毒蛇咬伤,乳腺炎。
三七,中药名。为五加科植物三七Panaxnotoginseng(Burk.)F.H.Chen的干燥根和根茎。散瘀止血,消肿定痛。《本草纲目》:止血散血定痛,金刃箭伤、跌扑杖疮、血出不止者,嚼烂涂,或为末掺之,其血即止。亦主吐血衄血,下血血痢,崩中经水不止,产后恶血不下,血运血痛,赤目痈肿,虎咬蛇伤诸病。
实施例1
春夏季采摘积雪草,干燥制备,泡入乙醇萃取,作为组分1;
取三七、薄荷、白芷与白芨用蒸馏法汽化成结晶,粉碎过细筛待用,作为组分2;
将其余原料玉竹,黄芪,益母草,桃仁,丹参,人参,红花,白芍,火棘果,白蔹,月季花,金盏花,龙胆草,天竺葵,玫瑰花,地桃花用乙醇提取2次,合并浓缩提取液,作为组分3;
将组分1、组分2与组分3混合后加基质搅拌均匀,加热,调和基质,成凝胶剂;所述基质选自:蜂胶、聚山梨酯-80、三乙醇胺、丙二醇,半合成脂肪酸甘油酯、泊洛沙姆、聚乙二醇、羊毛脂中的一种或多种调和,杀菌装罐。
实施例2:
春夏期间都可以采摘积雪草,将晾晒好的积雪草3500g切碎,过100-120目筛,将药粉置有盖不锈钢桶内,加70%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置。加热浓缩至膏状,静置备用,成组分1。将薄荷1000g、三七1000g、白芷1000g和白芨1000g用蒸馏法汽化成结晶,粉碎待用,为组分2;再将其他原料玉竹1000g,黄芪1000g,益母草1000g,桃仁1000g,丹参1000g,人参1000g,红花1000g,白芍1000g,火棘果1000g,白蔹1000g,月季花1000g,金盏花1000g,龙胆草1000g,天竺葵1000g,玫瑰花1000g,地桃花1000g,加入占其质量5-10倍量的乙醇浸泡4-6小时,加热提取2次,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置备用。将上述步骤提取的两种滤液,放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,再置入0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,成组分3。将组分1投入组分2中组分3,搅拌均匀,加热,调和基质,成凝胶剂;所述基质选自:聚山梨酯-80、三乙醇胺、丙二醇,半合成脂肪酸甘油酯、泊洛沙姆、聚乙二醇、羊毛脂中的一种或多种。
实施例3
春夏期间都可以采摘积雪草,将晾晒好的积雪草4000g浸泡水中12小时,然后放入提取罐加热煮沸1小时,过滤,滤液备用;滤渣加水,第二次加热,煮沸45分钟,过滤,滤液备用;滤渣再加水,第三次加热煮沸半小时,过滤;将三次滤液合在一起,用纱布过滤,残渣中加入50-60%乙醇,60℃-70℃继续浸提2h,每10min搅拌一次,纱布过滤,合并浸提液,成组分1;薄荷1000g、三七1100g、白芷1000g和白芨1100g用蒸馏法汽化成结晶,粉碎待用,为组分2;再取玉竹1100g,黄芪1200g,益母草1100g,桃仁1000g,丹参1000g,人参1000g,红花1000g,白芍1000g,火棘果1000g,白蔹1200g,月季花1100g,金盏花1200g,龙胆草1000g,天竺葵1000g,玫瑰花1000g,地桃花1200g,,用水浸泡,加热煮沸3次,每次1-2小时,过滤,滤液备用;将合并后3次的滤液抽入减压浓缩罐内,减压浓缩至相对密度为1.20,温度至60℃-70℃的浸膏;成为组分3,混合组分1和组分2组分3,调和基质,成凝胶剂;所述基质选自:蜂胶。
药理学毒性试验
毒理学试验:
试验例1:本发明急性毒性试验
一、试验材料:
动物:昆明种小鼠,体重21-24g,雌雄各半,山东大学生物试验室育种。药物:本发明美容霜。
二、方法:
1、LD50计算:采用改良寇氏法,将小鼠随机分成5组,每组10只,雌雄各半,将洗液剂溶解,配成最大浓度,按小鼠最大允许容量给药,所给剂量按生药量依次为18,14.4,11.5,9.2,7.4(g.kg-1),在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml,观察动物死亡情况。
2、最大耐受剂量测定(MTD值):取小鼠20只,雌雄各10只。将片剂加蒸馏水溶解,配成最高浓度,按动物的最大耐受量,以注射灌喂器能抽动为准。在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml(每ml含生药0.36g),总药量为18g生药/kg.d,相当临床成人50Kg体重用量的300倍。给药后连续观察7天。
三、试验结果:
在LD50计算中当用最大允许浓度和最大允许容量给予小鼠时(18g/Kg.d),未见小鼠死亡,即未测出LD50,只可求最大耐受剂量,在7天观察期中,动物其食欲、活动、毛色、精神状态等皆正常,发育正常,未见有死亡。即选用相当于临床剂量的300倍药量,并无不良反应发生,表明急性毒性极小,MTD>18g/Kg.d。
试验例2:本发明急性皮肤刺激试验报告
1、实验目的:检测本发明对实验动物皮肤的刺激/腐蚀作用和强度
2、材料和方法:
2.1.受试物名称:本发明美容霜(实施例方法2制得)
2.2.实验动物:壹级大耳白种家兔,10只,雌性,体重2.1-2.3kg;由青岛大学医学院生物系实验动物中心提供;
2.3.试验方法:
选用皮肤完好的健康家兔10只,于试验前24小时将其背部脊柱两侧被毛剪掉,去毛面积左、右各约4cm×4cm。试验时取受试物0.2ml涂于2.5cm×2.5cm的二层纱布上,敷贴于一侧去毛皮肤表面,油纸覆盖,胶布固定。另一侧皮肤作为空白对照。封闭4小时后,去除覆盖物,并用温水清洗去残留受试物,于去除受试物后的1、24和48小时观察涂抹部位皮肤反应,并评分。
3、实验结果:实验动物皮肤未出现任何红斑,红肿,发炎现象。
4、小结:根据《消毒技术规范》(1999)中皮肤刺激反应评分标准判定,本发明软膏剂对动物皮肤刺激强度属无刺激性。
实施例3:阴道粘膜刺激试验结果
1.试验方法:
实验动物检疫3天后,选用18只上述健康家兔,随机分为三组,每组各6只,分别为:空白对照、赋形剂对照、本发明眼霜。分别用适当大小的灭菌棉条浸以灭菌生理盐水和受试物置于赋形剂对照组和受试物组动物阴道内,与阴道粘膜接触6小时,24小时后处死动物。取出局部阴道组织,观察病变情况。
2、试验结果:阴道粘膜刺激试验结果
实施例4:皮肤过敏试验结果
用本发明美容霜,进行诱导和激发接触试验,在24小时和48小时后观察试验小鼠,均不见皮肤有红斑及水肿等现象,与阴性对照组无差异。结果表明,该膏剂对皮肤反应强度近于零,即无皮肤变态反应。
实施例5:长期毒性实验资料
1、实验方法
将豚鼠随机份成4组,每组15只。在豚鼠背部脊柱两侧将脱毛剂均匀涂上,使其脱毛范围约40平方厘米。洗净脱毛剂,观察24小时后每组豚鼠分别涂本发明眼霜0.2、0.4和0.8ml,分别含生药92、184和368mg,另一组涂溶媒0.8ml每日二次,连续30天,观察豚鼠的一般情况,实验结束后处死动物进行血液学、血液生化及病理学检查。
2、结果
上述三组用药豚鼠躯干去毛区,未见局部皮肤有水肿、充血、红斑、出血点及溃疡。用药组与对照组动物毛发色泽、摄食、四肢活动等对照组无明显差异,血液生化检查,用药组与对照组均在正常范围。病理组织学检查,实验各组心、肝、肾及局部皮肤均未见明显病变。提示,本发明中药眼霜长期用药对局部皮肤及全身重要脏器均未见明显的毒性作用。
药理学实验
一、本发明的微循环实验方法:
1、材料与方法:取50只小鼠,随机分成5组,每组10只(雌雄各半),对照组每鼠右耳涂生理盐水少许;阳性对照组每鼠右耳给予市售佰草集紧致抗皱美容霜(上海佰草集化妆品有限公司出品),受试组为本发明外用美容膏15ml。15min后腹腔注射0.1%戊巴比妥钠0.1ml/10g麻醉动物,随后尾静脉注射0.1%肾上腺素0.1mL/10g,立即观察小鼠右耳微动静脉口径(μm)及0.2mm2毛细血管网点数.t检验处理实验数据.
2结果与讨论
2.1.对微循环的影响
与对照组相比,受试组1对小鼠毛细血管开放数有明显增多(P<0.01);受试组2对微静脉口径和毛细血管开放数有显著增加(P<0.01);受试组3对小鼠微动、静脉口径及毛细血管开放数皆有增加(P<0.01);说明受试药能改善微循环,有活血化瘀作用(表1)。
表1、本发明美容膏对小鼠微动、静脉口径及毛细血管开放数的影响
二、对巴豆油所致小鼠耳廓肿胀的影响
取健康小鼠30只,随机分成3组,即空白对照组、佰草集新恒美紧肤眼霜阳性对照组、本发明美容膏,每组10只,雌雄各半,阳性对照组和本发明组分别涂抹,空白对照组涂抹等剂量的生理盐水,连续给药7天,于末次给药后0.5小时,在小鼠左耳内外测涂巴豆油致炎剂(2%巴豆油,20%无水乙醇,5%蒸馏水,73%乙醚)0.1ml致炎,致炎后4小时用打孔器(孔径6mm)打下左、右耳片,称重,以左右耳片重量差作为肿胀程度,结果见表2。
表2对巴豆油所致小鼠耳廓肿胀的影响(X±SD)
组别 | 动物数(只) | 肿胀度(mg) |
空白对照组 | 10 | 8.51±1.72 |
佰草集紧致抗皱美容霜 | 10 | 5.32±1.57** |
本发明美容膏组 | 10 | 4.26±1.39# |
注:与对照组比较:**P<0.01;与阳性对照组比较:#P<0.05;由上表实验结果可以看出,本发明眼霜具有更好的消肿药理作用。
三.对角叉菜胶所致大鼠足跖肿胀的影响
取健康大鼠30只,体重180-220g,随机分成空白对照组、佰草集紧致抗皱美容霜阳性对照组、本发明美容膏。每组10只,雌雄各半,分笼饲养。阳性对照组和本发明药物组分别每日涂抹0.2g,空白对照组给予同剂量的生理盐水涂抹,连续给药7天,于末次给药后30分钟,分别在大鼠右后足跖皮下注射1%角叉菜胶混悬液0.1ml/只致炎,分别于致炎前和致炎后15、30、60、120、240分钟测大鼠右后足跖的周长,并计算肿胀率【肿胀率=(致炎后足跖周长-致炎前足跖周长)/致炎前足跖周长×100%】;结果见表3。
表3对角叉菜胶所致大鼠足跖肿胀的影响(X±SD)
注:与对照组比较:**P<0.01;与阳性对照组比较:#P<0.05;由上表实验结果可以看出,本发明药物组具有更好的抗皱平肌肉,消除肌肤纹理的药理作用。
3讨论
临床试验
说明:我院于2014年6月-2015年6月,使用自制抗皱霜、对面部皱纹,颈部皱纹、眼角皱纹,疗效显著,现报道如下。
临床资料:临床选取面部皱纹,眼角皱纹、颈部皱纹明显者100例。全部为女性。年龄35-55岁,平均41.3岁;未婚者25例,已婚者75例,已育者65例;病程6个月-20年,平均9.58年;教育水平大学文化67人,白领、教师、干部、科室人员65例,其他人员22例。自述经常熬夜加班43例,遗传35倒,失眠20例,每日保养皮肤者78人,激光治疗祛皱26人。临床分为治疗组50例,对照组50例。
治疗方法:治疗组采用自制中药美容膏,方用:积雪草30g,玉竹11g,黄芪12g,益母草11g,三七12g,丹参12g,桃仁13g,人参13g,红花11g,白芍12g,白芨12g,薄荷12g,火棘果11g,白蔹12g,白芷13g,月季花12g,金盏花12g,龙胆草11g,天竺葵11g,玫瑰花12g,地桃花11g。按实施例2的方法制备成眼霜。
取对照组,每组50例,分别使用市售的佰草集紧致抗皱美容霜。
操作过程:进行时人员平卧床上,用3%双氧水清洁面部,用负离子喷雾器喷雾面部,同时配合经络穴位按摩十二法进行面部按摩,眼周局部做重点按摩,时间约10min.后取眼霜,均匀涂于脸部,注意不要弄进眼睛,可适当按摩10-15分钟。每日一次,15天一疗程。疗程结束后,每月随访1次,连续随访3个月。治疗期间嘱病人少食辛辣,注意休息,并停用其它美容护理品。
疗效标准
痊愈:治疗2疗程后,脸部肌肤紧致,脸部皱纹,眼袋、眼角皱纹明显淡化,且疗效维持1个月以上,脸部肌肤略有改善紧致,眼疲劳缓解;有效:眼袋、眼角皱纹明显变淡,消退50%以上,病人自觉满意,睡眠质量好;或治疗期间眼袋消失,但随访中睡眠不好,加班又有复发;无效:眼袋、眼角皱纹改变不明显或无变化;或曾消退50%以上,但随访中明显加重,试验人员不满意。
治疗结果:治疗组总有效率与各对照组比较,差别均有显著性(P<0.01),说明自制美容膏疗效明显优于市售紧致抗皱产品。详见表4
表43组疗效对比表(%)
注:与其他各组比较*P<0.01
随访结果随访发现,按摩者强于不按摩的人士。复发后,若继续使用仍然有效。积雪草具有清热解毒,利湿消肿、滋补、消炎、镇定的作用。能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。既能促进表皮与真皮之间的密切连接,又能抑制脂肪细胞的增加,防止皮肤水肿、出现肥胖。
Claims (10)
1.一种缓解皱纹的积雪草中药美容抗皱膏,其特征在于,所述中药抗皱膏中包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
2.根据权利要求1所述缓解皱纹的积雪草中药美容抗皱膏,其特征在于,所述中药抗皱膏中包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
3.根据权利要求1所述缓解皱纹的积雪草中药美容抗皱膏,其特征在于,所述中药抗皱膏中包括以下重量份数的原料药:积雪草10~50份,玉竹10~20份,黄芪10~20份,益母草10~20份,三七10~20份,丹参10~20份,桃仁10~20份,人参10~20份,红花10~20份,白芍10~20份,白芨10~20份,薄荷10~20份,火棘果10~20份,白蔹10~20份,白芷10~20份,月季花10~20份,金盏花10~20份,龙胆草10~20份,天竺葵10~20份,玫瑰花10~20份,地桃花10~20份。
4.一种如权利要求1~3中任一项所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述制备方法包括以下步骤:
a.积雪草的制备,萃取,作为组分1;
b.取薄荷、三七、白芷与白芨用蒸馏法汽化成结晶,粉碎过细筛待用,作为组分2;
c.将其余原料药用乙醇提取2次,合并浓缩提取液,作为组分3;
d.将组分1、组分2与组分3混合后加基质调和,杀菌装罐。
5.根据权利要求4所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述步骤a中,取春夏季将采摘好的积雪草切碎,过80-100目筛。
6.根据权利要求4所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述步骤a中,萃取的步骤是,将药粉置于有盖不锈钢桶内,加70%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置。加热浓缩至膏状,静置备用,成组分1。
7.根据权利要求4所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述步骤b中,取薄荷、三七、白芷与白芨用蒸馏法汽化成结晶,粉碎过120-150目细筛待用,作为组分2。
8.根据权利要求4所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述步骤c中,将所述其余原料加入占其质量5-10倍量的乙醇浸泡4-6小时,加热提取2次,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,再置入0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,作为组分3。
9.根据权利要求4所述缓解皱纹的积雪草中药美容抗皱膏的制备方法,其特征在于,所述步骤d中,将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,成凝胶剂;所述基质选自:蜂胶、聚山梨酯-80、三乙醇胺、丙二醇,半合成脂肪酸甘油酯、泊洛沙姆、聚乙二醇、羊毛脂中的一种或多种。
10.根据权利要求1~8中任一项所述缓解皱纹的积雪草中药美容抗皱膏的使用方法,其特征在于,抗皱美容膏的使用方法是,每次临睡前洁面后,将抗皱膏均匀涂抹于脸部,并用中指指肚在脸部按摩15-20分钟,至其充分吸收后,第二天早起洗去即可。
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