CN109563158B - 抗补体因子bb抗体以及其用途 - Google Patents

抗补体因子bb抗体以及其用途 Download PDF

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Publication number
CN109563158B
CN109563158B CN201780029742.9A CN201780029742A CN109563158B CN 109563158 B CN109563158 B CN 109563158B CN 201780029742 A CN201780029742 A CN 201780029742A CN 109563158 B CN109563158 B CN 109563158B
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antibody
amino acid
seq
acid sequence
cdr
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CN109563158A (zh
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桑迪普·帕尼克
格雷汉姆·帕里
凯伦·苏·克里斯托弗森
托尼·桑永·布云
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Genzyme Corp
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Biobelli America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780029742.9A 2016-04-04 2017-04-03 抗补体因子bb抗体以及其用途 Active CN109563158B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210862505.3A CN116790614A (zh) 2016-04-04 2017-04-03 抗补体因子bb抗体以及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317897P 2016-04-04 2016-04-04
US62/317,897 2016-04-04
PCT/US2017/025784 WO2017176651A1 (en) 2016-04-04 2017-04-03 Anti-complement factor bb antibodies and uses thereof

Related Child Applications (1)

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CN202210862505.3A Division CN116790614A (zh) 2016-04-04 2017-04-03 抗补体因子bb抗体以及其用途

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CN109563158A CN109563158A (zh) 2019-04-02
CN109563158B true CN109563158B (zh) 2022-08-09

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CN202210862505.3A Pending CN116790614A (zh) 2016-04-04 2017-04-03 抗补体因子bb抗体以及其用途

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US (3) US10934347B2 (https=)
EP (1) EP3452510A4 (https=)
JP (3) JP6967528B2 (https=)
KR (2) KR20240096672A (https=)
CN (2) CN109563158B (https=)
AU (2) AU2017246794B2 (https=)
BR (1) BR112018070357A2 (https=)
CA (1) CA3019332A1 (https=)
CL (1) CL2018002810A1 (https=)
CO (1) CO2018010827A2 (https=)
CR (1) CR20180529A (https=)
DO (1) DOP2018000219A (https=)
EA (1) EA201892225A1 (https=)
EC (1) ECSP18082302A (https=)
IL (3) IL311675A (https=)
MA (1) MA44878A (https=)
MX (2) MX2018012176A (https=)
MY (1) MY194603A (https=)
PE (1) PE20190209A1 (https=)
PH (1) PH12018502137A1 (https=)
SG (1) SG11201808525UA (https=)
TN (1) TN2018000341A1 (https=)
WO (1) WO2017176651A1 (https=)

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JP6967528B2 (ja) 2016-04-04 2021-11-17 バイオベラティブ ユーエスエー インコーポレイテッド 抗補体Ｂｂ因子抗体及びその使用
CA3043251A1 (en) * 2016-12-09 2018-06-14 Gliknik Inc. Methods of treating inflammatory disorders with multivalent fc compounds
CN110177802A (zh) 2016-12-09 2019-08-27 格利克尼克股份有限公司 多聚化stradomer GL-2045的制造优化
US11690919B2 (en) * 2017-01-17 2023-07-04 The Texas A&M University System Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells
CN111527105B (zh) * 2017-10-11 2024-10-25 美国比奥维拉迪维股份有限公司 诱导补体活性的方法
US11905533B2 (en) 2017-12-19 2024-02-20 The University Of North Carolina At Chapel Hill Methods and compositions for delivery of viral vectors across the blood-brain barrier
KR20220042128A (ko) * 2019-06-27 2022-04-04 베르조 테라퓨틱스, 아이엔씨. 골수성 세포 염증성 표현형을 조절하기 위한 항-cd53 조성물 및 방법, 그리고 이의 용도
AR122286A1 (es) * 2019-07-17 2022-08-31 Gemini Therapeutics Sub Inc Anticuerpos potenciadores del factor h y usos de estos
US20230050339A1 (en) * 2020-02-18 2023-02-16 Children's Hospital Medical Center Compositions and methods for treating liver disease
KR20230004686A (ko) * 2020-04-20 2023-01-06 젠자임 코포레이션 인간화 항-보체 인자 Bb 항체 및 그의 용도
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BR112018070357A2 (pt) 2019-01-29
CL2018002810A1 (es) 2019-03-15
CR20180529A (es) 2019-03-21
JP2021191789A (ja) 2021-12-16
JP7326393B2 (ja) 2023-08-15
US10934347B2 (en) 2021-03-02
DOP2018000219A (es) 2019-03-31
EP3452510A1 (en) 2019-03-13
CN109563158A (zh) 2019-04-02
ECSP18082302A (es) 2019-01-31
MA44878A (fr) 2019-03-13
MY194603A (en) 2022-12-06
KR20240096672A (ko) 2024-06-26
US20240228599A1 (en) 2024-07-11
MX2018012176A (es) 2019-02-07
AU2017246794B2 (en) 2024-07-04
CO2018010827A2 (es) 2018-11-22
IL295288B1 (en) 2024-04-01
IL295288A (en) 2022-10-01
EP3452510A4 (en) 2020-01-15
IL262010A (en) 2018-10-31
MX2023007149A (es) 2023-06-28
PE20190209A1 (es) 2019-02-07
TN2018000341A1 (en) 2020-06-15
IL311675A (en) 2024-05-01
WO2017176651A1 (en) 2017-10-12
US20210221877A1 (en) 2021-07-22
JP2023139289A (ja) 2023-10-03
JP2019513726A (ja) 2019-05-30
CN116790614A (zh) 2023-09-22
AU2024224000A1 (en) 2024-12-19
EA201892225A1 (ru) 2019-09-30
CA3019332A1 (en) 2017-10-12
US20190153079A1 (en) 2019-05-23
SG11201808525UA (en) 2018-10-30
IL262010B (en) 2022-09-01
PH12018502137A1 (en) 2019-09-23
US11851482B2 (en) 2023-12-26
KR20190003951A (ko) 2019-01-10
AU2017246794A1 (en) 2018-10-25
NZ747018A (en) 2025-05-02
KR102673420B1 (ko) 2024-06-07
IL295288B2 (en) 2024-08-01
JP6967528B2 (ja) 2021-11-17

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