CN109562185A - 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 - Google Patents

药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 Download PDF

Info

Publication number
CN109562185A
CN109562185A CN201780047924.9A CN201780047924A CN109562185A CN 109562185 A CN109562185 A CN 109562185A CN 201780047924 A CN201780047924 A CN 201780047924A CN 109562185 A CN109562185 A CN 109562185A
Authority
CN
China
Prior art keywords
formula
conjugate
base
nch
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780047924.9A
Other languages
English (en)
Chinese (zh)
Inventor
S·佩特里
O·普勒滕贝格
N·特纳格尔斯
U·韦尔纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of CN109562185A publication Critical patent/CN109562185A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
CN201780047924.9A 2016-06-02 2017-06-02 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 Pending CN109562185A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16305640 2016-06-02
EP16305640.1 2016-06-02
PCT/EP2017/063447 WO2017207754A1 (en) 2016-06-02 2017-06-02 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein

Publications (1)

Publication Number Publication Date
CN109562185A true CN109562185A (zh) 2019-04-02

Family

ID=56121007

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780047924.9A Pending CN109562185A (zh) 2016-06-02 2017-06-02 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物

Country Status (13)

Country Link
US (3) US11090364B2 (enExample)
EP (1) EP3463480A1 (enExample)
JP (1) JP2019520342A (enExample)
KR (1) KR20190015413A (enExample)
CN (1) CN109562185A (enExample)
AU (1) AU2017272862A1 (enExample)
BR (1) BR112018074716A2 (enExample)
CA (1) CA3025988A1 (enExample)
IL (1) IL263390A (enExample)
MX (1) MX2018014929A (enExample)
RU (1) RU2018147235A (enExample)
SG (1) SG11201810701XA (enExample)
WO (1) WO2017207754A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115920081A (zh) * 2022-11-02 2023-04-07 重庆大学 红细胞膜自发定向包被ros响应的纳米前药及其应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3025988A1 (en) * 2016-06-02 2017-12-07 Sanofi Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
CN111433193A (zh) 2017-12-01 2020-07-17 赛诺菲 药剂和能够结合至葡萄糖传感蛋白的部分的新型缀合物
US12378229B2 (en) 2021-02-02 2025-08-05 Liminal Biosciences Limited GPR84 antagonists and uses thereof
WO2025199666A1 (en) * 2024-03-25 2025-10-02 Canwell Biotech Limited Multivalent linkers for high loading antibody-drug conjugates, and compositions and methods thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010088300A1 (en) * 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
WO2010107520A1 (en) * 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
CN102026666A (zh) * 2007-12-11 2011-04-20 康久化学生物技术公司 促胰岛素肽缀合物制剂
CN102365025A (zh) * 2009-01-28 2012-02-29 斯马特塞尔斯公司 用于受控药物递送的基于缀合物的系统
CN103037690A (zh) * 2010-03-24 2013-04-10 俄亥俄州立大学 用于葡萄糖转运抑制的组合物和方法
WO2013182612A1 (en) * 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
US20150105317A1 (en) * 2013-10-04 2015-04-16 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
CN108778318A (zh) * 2016-01-14 2018-11-09 北卡罗莱纳州立大学 葡萄糖响应性胰岛素递送组合物和方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK111489D0 (da) 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2003535106A (ja) 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
EP1453860A2 (en) 2001-12-02 2004-09-08 Novo Nordisk A/S Novel glucose-dependant insulins
FR2929615B1 (fr) 2008-04-02 2010-12-17 Tfchem Composes c-aryl glycosides pour le traitement du diabete et de l'obesite.
CN101638423B (zh) 2008-07-29 2012-09-05 常州高新技术产业开发区三维工业技术研究所有限公司 根皮苷衍生物及其制备方法和用途
US20110230403A1 (en) 2008-09-19 2011-09-22 Novartis Ag Glycoside derivatives and uses thereof
EP2448962B1 (en) 2009-06-30 2016-10-19 Novo Nordisk A/S Insulin derivatives
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
WO2013121296A1 (en) 2012-02-15 2013-08-22 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
JP2014510782A (ja) 2011-04-14 2014-05-01 ノバルティス アーゲー グリコシド誘導体およびその使用
PL2721045T3 (pl) 2011-06-20 2017-11-30 Radiomedix Inc. Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych
KR20140145148A (ko) 2012-03-21 2014-12-22 에리테끄 파르마 급성 골수성 백혈병 치료를 위한 약제
EP2813234A1 (en) 2013-06-11 2014-12-17 Erytech Pharma Composition of erythrocytes encapsulating phenylalanine hydroxylase and therapeutic use thereof
ES2742102T3 (es) 2014-01-15 2020-02-13 Baseclick Gmbh Moléculas de ácido nucleico modificadas con sacárido
FR3017299B1 (fr) 2014-02-12 2018-05-18 Erytech Pharma Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
CA3025988A1 (en) 2016-06-02 2017-12-07 Sanofi Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102026666A (zh) * 2007-12-11 2011-04-20 康久化学生物技术公司 促胰岛素肽缀合物制剂
WO2010088300A1 (en) * 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
CN102365025A (zh) * 2009-01-28 2012-02-29 斯马特塞尔斯公司 用于受控药物递送的基于缀合物的系统
WO2010107520A1 (en) * 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
CN103037690A (zh) * 2010-03-24 2013-04-10 俄亥俄州立大学 用于葡萄糖转运抑制的组合物和方法
WO2013182612A1 (en) * 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
US20150105317A1 (en) * 2013-10-04 2015-04-16 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
CN108778318A (zh) * 2016-01-14 2018-11-09 北卡罗莱纳州立大学 葡萄糖响应性胰岛素递送组合物和方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IVONE CARVALHO. ET AL: "‘Click chemistry’ synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
JOCHEN LEHMANN ，MARKUS SCHEURING: "Mono-, di- and tri-antennary d-galactose ligands as competitive inhibitors and photoaffinity labels of the hexose transporting system in erythrocytes. A model for the irreversible blocking of receptors in cell membranes", 《CARBOHYDRATE RESEARCH》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115920081A (zh) * 2022-11-02 2023-04-07 重庆大学 红细胞膜自发定向包被ros响应的纳米前药及其应用

Also Published As

Publication number Publication date
WO2017207754A1 (en) 2017-12-07
CA3025988A1 (en) 2017-12-07
SG11201810701XA (en) 2018-12-28
BR112018074716A2 (pt) 2019-03-12
AU2017272862A1 (en) 2019-01-17
RU2018147235A (ru) 2020-07-10
US20210401947A1 (en) 2021-12-30
KR20190015413A (ko) 2019-02-13
IL263390A (en) 2018-12-31
US11090364B2 (en) 2021-08-17
JP2019520342A (ja) 2019-07-18
US20190209656A1 (en) 2019-07-11
MX2018014929A (es) 2019-08-26
US20210401946A1 (en) 2021-12-30
EP3463480A1 (en) 2019-04-10

Similar Documents

Publication Publication Date Title
CN109562185A (zh) 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物
CN105121426B (zh) 吡咯烷gpr40调节剂
CN101754966B (zh) 丙型肝炎病毒抑制剂
CN105705501B (zh) RORγ调节剂
CN106117309B (zh) 丙型肝炎病毒的抑制剂
HK1210483A1 (en) Macrocyclic inhibitors of flaviviridae viruses
CN105209467A (zh) 咪唑并吡咯烷酮衍生物及其在治疗疾病中的用途
HK1211285A1 (en) Macrocyclic inhibitors of flaviviridae viruses
KR20230024361A (ko) Il-17의 소분자 조절제
CN103249730A (zh) 丙型肝炎病毒抑制剂
CN110526903A (zh) 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN109689664B (zh) 作为par4抑制剂的三环杂芳基取代的喹啉和氮杂喹啉化合物
CA3197092A1 (en) 1-(2-(4-cyclopropyl-1h-1,2,3-triazol-1-yl)acetyl)-4-hydroxy-n-(benzyl)pyrrolidin e-2-carboxamide derivatives as vhl inhibitors for the treatment of anemia and cancer
US20260091022A1 (en) Pharmaceutical composition for treating fatty liver disease
CN111630047A (zh) 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途
WO2025106586A1 (en) Macrocyclic ketone compounds and applications thereof
EP3717463A1 (en) Novel conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
WO2026044024A1 (en) Compositions comprising combinations of pharmaceutically acceptable salts and other derivatives of glucagon-like peptide-1 receptor agonist and pharmaceutically acceptable salts and other derivatives of amylin analog, and uses thereof
HK40082231A (en) Pharmaceutical for treating fatty liver diseases
WO2025184608A1 (en) Compositions comprising pharmaceutically acceptable salts and other derivatives of an amylin analog and uses thereof
CN115536576A (zh) 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用
CN120265641A (zh) GHSR 1a激动剂、药物组合物及其制备方法和应用
HK40056262A (en) Therapeutic compounds
HK40005106B (zh) 大环吲哚衍生物
HK1232545A1 (en) Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of asgpr

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
AD01 Patent right deemed abandoned

Effective date of abandoning: 20230228