CN109535010B - 一种盐酸溴己新的制备方法 - Google Patents
一种盐酸溴己新的制备方法 Download PDFInfo
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- CN109535010B CN109535010B CN201811613124.1A CN201811613124A CN109535010B CN 109535010 B CN109535010 B CN 109535010B CN 201811613124 A CN201811613124 A CN 201811613124A CN 109535010 B CN109535010 B CN 109535010B
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- aminobenzoate
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- dibromo
- bromhexine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
- C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
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CN201811613124.1A CN109535010B (zh) | 2018-12-27 | 2018-12-27 | 一种盐酸溴己新的制备方法 |
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CN201811613124.1A CN109535010B (zh) | 2018-12-27 | 2018-12-27 | 一种盐酸溴己新的制备方法 |
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CN109535010A CN109535010A (zh) | 2019-03-29 |
CN109535010B true CN109535010B (zh) | 2021-10-26 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111072499B (zh) * | 2019-11-14 | 2022-08-16 | 山东罗欣药业集团股份有限公司 | 一种盐酸氨溴索的合成工艺 |
CN110922336A (zh) * | 2019-12-12 | 2020-03-27 | 南京恒道医药科技有限公司 | 一种连续制备氨溴索高纯度关键中间体2-氨基-3,5-二溴苯甲酸的方法 |
WO2023058050A1 (en) * | 2021-10-04 | 2023-04-13 | Council Of Scientific And Industrial Research | A process for preparation of pharmaceutically active compounds via selective nitro reduction reactions |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2411848A1 (de) * | 1973-03-15 | 1974-09-26 | Huhtamaeki Yhthymae Oy | Verfahren zur herstellung eines cyclohexylaminderivats |
JPS5089345A (zh) * | 1973-12-13 | 1975-07-17 | ||
CN103396323A (zh) * | 2013-08-07 | 2013-11-20 | 张嵩 | 一种盐酸溴己新的生产方法 |
CN104086445A (zh) * | 2014-07-15 | 2014-10-08 | 浙江万邦药业股份有限公司 | 一种盐酸溴己新及制剂有关物质的检测方法 |
CN104610073A (zh) * | 2013-11-06 | 2015-05-13 | 康普药业股份有限公司 | 盐酸溴己新的合成生产方法 |
CN104628577A (zh) * | 2015-01-24 | 2015-05-20 | 上海默学医药科技有限公司 | 盐酸溴己新的合成方法 |
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- 2018-12-27 CN CN201811613124.1A patent/CN109535010B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2411848A1 (de) * | 1973-03-15 | 1974-09-26 | Huhtamaeki Yhthymae Oy | Verfahren zur herstellung eines cyclohexylaminderivats |
JPS5089345A (zh) * | 1973-12-13 | 1975-07-17 | ||
CN103396323A (zh) * | 2013-08-07 | 2013-11-20 | 张嵩 | 一种盐酸溴己新的生产方法 |
CN104610073A (zh) * | 2013-11-06 | 2015-05-13 | 康普药业股份有限公司 | 盐酸溴己新的合成生产方法 |
CN104086445A (zh) * | 2014-07-15 | 2014-10-08 | 浙江万邦药业股份有限公司 | 一种盐酸溴己新及制剂有关物质的检测方法 |
CN104628577A (zh) * | 2015-01-24 | 2015-05-20 | 上海默学医药科技有限公司 | 盐酸溴己新的合成方法 |
Non-Patent Citations (2)
Title |
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固体超强酸催化剂的研究进展;刘桂荣等;《江西化工》;20050930(第03期);第25页右栏倒数第2段,第24页右栏第3.1.1节,第26页4.7节 * |
盐酸氨澳索的合成;于书海等;《中国医药工业杂志》;19961231;第27卷(第10期);第436页左栏第4段 * |
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Effective date of registration: 20221110 Address after: No.6, Dongbo Road, East District, Shenzhen Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Address before: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee before: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20221226 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Patentee after: Guangdong Ruishi Pharmaceutical Technology Co.,Ltd. Address before: No.6, Dongbo Road, East District, Shenzhen Economic and Technological Development Zone, Guangdong 510000 Patentee before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee before: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee before: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee before: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee before: Euphorbia Biological Medicine Co.,Ltd. |
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