CN109528533A - A kind of cosmetics and preparation method thereof containing choline cloves hydrochlorate - Google Patents

Abstract

The invention discloses a kind of cosmetics and preparation method thereof containing choline cloves hydrochlorate, and the raw material for preparing of the cosmetics includes following components: choline cloves hydrochlorate, solvent, conditioner, moisturizer, surfactant and thickener.Raw material will be prepared and be divided into A, B, C, D and E phase, as follows prepared by step: after S1, the processing that carries out disinfection to emulsion pot, A phase raw material is added, stirring to all the components is uniformly dispersed；80~90 DEG C are warming up under S2, uniform stirring, 20~40min of insulated and stirred；S3, it is cooled to 50~65 DEG C under uniform stirring, B phase raw material is added, and it is uniform to B phase stock dispersion to continue stirring；S4,40~45 DEG C are cooled to, C phase raw material is added, stirs evenly；S5,40 DEG C are cooled to hereinafter, addition D phase raw material, stirs evenly；S6, E phase raw material is added, stops stirring after mixing evenly, cools down up to the cosmetics.

Description

A kind of cosmetics and preparation method thereof containing choline cloves hydrochlorate

Technical field

The present invention relates to cosmetics manufacturing technology fields, and in particular to a kind of cosmetics containing choline cloves hydrochlorate and its Preparation method.

Background technique

As the improvement of people's living standards, people are higher and higher for the pursuit of beauty, therefore, especially for cosmetics It is that skin care item propose increasingly higher demands.Mildy wash is a kind of common face's clean type skin care item, can not only clean surface Portion's dirt, but also makeup removing function is had together.Mildy wash best in quality should have the function such as cleaning, nutrition, protection skin Effect.Usually, mildy wash is made of Multiple components such as oil phase thing, aqueous-phase material, surfactant, moisturizer, nutritional agents Liquiform product.The product of various trait is suitable for different skin quality, and butyrous mildy wash contains oil-phase component, is suitable for stemness skin Skin uses；Crystal clear product is free of oil-phase component, and such as formula conditioning is appropriate, can meet most consumers and use.It is clean Surfactant has wetting, dispersion, foaming, decontamination, five big effects of emulsification in the cream of face, is the chief active object of face cleaning product.This Outside, according to the similar principle that mixes, during washing one's face, the oil-soluble rouge dirt of oil phase thing dissolution face and extra grease can be borrowed； By means of water-soluble sweat stain dirt on its aqueous-phase material dissolution face.

Mildy wash pure color, fragrance are simple and elegant, quality is fine and smooth, have preferable mobility, ductility and permeability, use it Face cleaning can remove sweat stain, grease, foundation cream, the scurf etc. of face, can wash away greasepaint, cosmetics, lipstick, eyebrow pencil mark with its makeup removing Deng being especially difficult to the eye shadow cream removed.Having the mildy wash of some special natures can also use in anhydrous conditions, can not only Skin of face is cleaned, while also having the functions such as skin care, moisturizing, skin nutrition concurrently, can make face skin tender bright and clean after.Due to There is clean skin health-care efficacy with the mildy wash makeup removing that washes one's face, have the advantages that use perfumed soap clean skin incomparable.Therefore, mildy wash is more next It is more welcomed by the people.

Mildy wash can be divided into four major class: sulfate mildy wash, soap base mildy wash, collagen egg according to its main composition White type mildy wash and amino acid pattern mildy wash；Sulfate mildy wash refers to sulfonate of laurate sodium sulphate and laureth sodium sulfovinate is Main active, soap base mildy wash refer to using fatty bronsted lowry acids and bases bronsted lowry as main component, fatty acid are obtained after saponification The ingredient of the auxiliary such as soap, polyalcohol, emulsifier, emollient.This kind of mildy wash cleaning capacity is strong, and due to containing alkali, entirety is in Alkalinity, degreasing protein ability is stronger, is highly suitable for oily skin.However, this kind of mildy wash, also easily since alkalinity is too strong, no It is enough mild, it is not suitable for sensitive skin, further, since cleaning capacity is strong, frequently uses, excessive cleaning is also resulted in, after washing There is face's drying, tight feeling；If being used for a long time, cuticula can be not only removed, skin surface can be also damaged, be easy to quick It causes to stimulate in sense position.Collagen type mildy wash, it is gentle comfortable using no soap base formula, it can be effectively removed including black Face's cutin and dirt including pigment make skin restore transparent salubrious state.Nano-collagen ingredient in product is fast Speed penetrates into skin, while promoting skin metabolism, also increases one layer of protective barrier for face, it is therefore prevented that face's epidermis water The loss and extraneous pollutant divided largely are penetrated into, to protect skin not by the invasion of adverse factor, but it cleans dynamics It is relatively weak.Amino acid pattern mildy wash, be with weakly acidic amino acid surfactant face cleaning product as main component, due to The pH value of weak acid acidic amino acid is closer to skin pH value, along with amino acid itself is the basic object for constituting protein again, therefore, This kind of mildy wash milder pro-skin, irritation is smaller, is applicable to child and sensitive skin, similarly, cleans dynamics also phase To weaker.In conclusion all kinds of mildy wash have a single function in the prior art, it is difficult to meet the composite demand of user.

Choline is a kind of biostearin, while being also nutrient needed by human.It is the important component for constituting cell membrane, It is also one of the raw material of human body synthesis glycine.It is separated first from pig's bile by Andreas Strecker within 1864, It is synthesized chemically within 1866.The intracorporal choline of people, which has, greatly to be derived from food, and trimethylamine is broken down into large intestine. Choline is a kind of strong organic base, is the constituent of lecithin, exists among sphingomyelin, is that body can be changed methyl One source and the product for acting on synthesizing methyl, while being the precursor of acetylcholine again, it is also regarded as helping to mankind's brain Development and memory.Human body can also synthesize choline, therefore, not easily cause deficiency disease.Choline is heat-resisting, in processing and gastronomical process Loss seldom, under dry environment, has almost no change content of choline in some time storage food.Choline is lecithin Sphingomyelins important component, lecithin is phosphatidyl choline, is widely present in animals and plants.The mankind and rat milk A large amount of choline can be provided for newborn, it is ensured that the mechanism and multiple of fetus an d neonate acquisition choline.A small amount of phosphatide in film Composition, including phosphatidyl 01 derivatives, Cholinphospholipide, especially phosphatidyl choline and sphingomyelin, are that can amplify External signal or the bioactive molecule by generating inhibition second messenger abort signal process.Choline is also to regulating cell Apoptosis has the irreplaceable important specific function of other methyl donors.Choline has affinity to fat, can promote rouge Fat is transferred out by liver by blood with phospholipid form or is improved utilization of the fatty acid in liver itself, and prevents fat in liver Abnormal accumulation in dirty.If fat, which accumulates in, fatty liver occurs without choline in liver, in morbid state.Clinically, using choline Cirrhosis, hepatitis and other liver diseases are treated, are worked well.Choline and inositol (another vitamin B) are cooperated together to carry out Utilization to fat and cholesterol；Choline is a small number of one of substances that can pass through " blood brain barrier ".This " barrier " protects brain Portion is not influenced by the change of diet.But choline can enter brain cell by this " barrier ", manufacture the chemistry being memonic Substance.Currently, the skin care effect research for choline is relatively fewer, choline is added in the cosmetics of part, but effect is still inadequate It is ideal.

Syringic acid is distributed in compositae plant knitting wool grass, overground part ericad rhododendron dauricum, leaf korean rhododendron, Ye Bai In the natural plants such as flower cuckoo, Ye little Hua cuckoo, leaf umbelliferae fennel, widely applied to medicine, fragrance, pesticide It learns and organic synthesis is industrial.Syringic acid also has pharmacological action, antibacterial action and central inhibitory action, while also having anti-thin Bacterium, fungi and calmness, local anaesthesia effect.Syringic acid also has certain anti-cataract activity, especially combines with dendrophnol It is stronger to AR rejection, it has been established centainly for the development and utilization and development anti-diabetic cataract new drug of syringic acid resource Basis.Currently, rarely having the correlative study that syringic acid is added to cosmetics.

Cosmetics in the prior art, still to rely on other cosmetics moisturizings such as mildy wash cleaning, face cream, hair conditioning skin care Product are anti-oxidant, anti-acne, this to need multiple operations when nursing, the time are not only expended, moreover, can also be due to occurring between each product Antagonism causes ineffective, or even generates to the harmful ingredient of skin, therefore, if can will prepare it is a kind of both had it is clean Face, moisturizing, but the cosmetics with anti-oxidant anti-inflammatory antianaphylactic effect will be of great significance.If can be by choline and syringic acid In conjunction with being added in cosmetics, will be expected to realize the above problem, however, there has been no relevant reports at present.

Summary of the invention

The technical problems to be solved by the present invention are: providing one kind with face cleaning, moisturizing and anti-oxidant anti-inflammatory antiallergy Cosmetics and preparation method thereof.

In order to solve the above-mentioned technical problem, a kind of the technical solution adopted by the present invention are as follows: change containing choline cloves hydrochlorate The raw material for preparing of cosmetic, the cosmetics includes following components: choline cloves hydrochlorate, solvent, conditioner, moisturizer, surface are living Property agent and thickener.

Further, the choline cloves hydrochlorate is 0.01~5% preparing the weight ratio in raw material.

Further, the choline cloves hydrochlorate, solvent, conditioner, moisturizer, the weight of surfactant and thickener The ratio between number are as follows: (0.01~5): (25~35): (2~5): (30~40): (15~25): (0.1~3).

Further, the solvent is water；The conditioner includes sodium chloride and essence；The moisturizer include glycerol, Sorbierite and sodium lactate；The surfactant includes sodium lauroyl glutamate (preferably BAFEORII GPW100) and alkyl Glucosides (Alkyl Polyglycoside, APG, preferably APG1214)；The thickener include poly bis stearate (preferably DM638)。

Further, the raw material for preparing further includes pearling agent.

Further, the raw material for preparing further includes preservative.

Further, the cosmetics are skin care item.

Further, the skin care item are mildy wash.

The beneficial effects of the present invention are: the present invention program provides a kind of cosmetic formulations added with natural ion salt And preparation method, it can effectively solve to be also easy to produce irritation or effect to skin existing for the cosmetics such as mildy wash in background technique The problems such as insufficient；The cosmetics such as mildy wash in the prior art, because of ingredient and during preparing, functional component is different, to flesh Skin allergy causes product market irregular, the problem of effect difference.Not only ingredient is scientific and reasonable for the mildy wash of biological ion salt, And safe ready, the present invention program add " natural ion salt " choline cloves hydrochlorate and (use green chemical synthesis technology system It is standby), dissolubility enhances about 3 orders of magnitude than mono-acid cloves solubility in acid, can be good at locking moisture of skin, avoids skin water Shunt the dry skin lost and caused.The thermal stability of the natural ion salt reaches 150 degrees Celsius, has both choline and syringic acid is double Principal characteristic matter, inoxidizability and anti-inflammatory bactericidal properties enhance wetting and protection to skin.Since this natural ion salt is based on choline Class ion is extracted from natural animal-plant, therefore, can be as the important functional component in cosmetic formulations.

The invention also includes the preparation method of the above-mentioned cosmetics containing choline cloves hydrochlorate, the solvent is water；It is described Conditioner includes sodium chloride and essence；The moisturizer includes glycerol, sorbierite and sodium lactate；The surfactant includes the moon Osmanthus acyl sodium glutamate and alkyl glycosides；The thickener includes poly bis stearate；

Raw material will be prepared and be divided into A, B, C, D and E phase, A phase raw material includes water, sodium chloride, glycerol and sorbierite；B phase raw material Including sodium lauroyl glutamate, C phase raw material includes alkyl glycosides and poly bis stearate, and D phase raw material includes sodium lactate, and E phase is former Material includes choline cloves hydrochlorate and essence；

As follows prepared by step:

After S1, the processing that carries out disinfection to emulsion pot, A phase raw material is added, stirring to all the components is uniformly dispersed；

80~90 DEG C are warming up under S2, uniform stirring, 20~40min of insulated and stirred；

S3, it is cooled to 50~65 DEG C under uniform stirring, B phase raw material is added, and it is equal to B phase stock dispersion to continue stirring It is even；

S4,40~45 DEG C are cooled to, C phase raw material is added, stirs evenly；

S5,40 DEG C are cooled to hereinafter, addition D phase raw material, stirs evenly；

S6, E phase raw material is added, stops stirring after mixing evenly, cools down up to the cosmetics.

Further, the cooling operation in the step S3 is cooled down with the speed of 1-3 DEG C/min.

The beneficial effects of the present invention are: all contact cosmetics raw and auxiliary materials, the equipment of semi-finished product, use during the preparation process Tool, pipeline are with the production of nontoxic, harmless, anti-anticorrosion material, and inner wall smooth is without falling off；Production equipment carries out periodic maintenance, protects It supports and cleaning, production equipment will not introduce security risks substance.Each ingredient is dexterously classified, the raw material of the same category Ingredient adds at different temperatures, adds each raw material component by the sequence and temperature of the present invention program, can not only utmostly protect There is its active constituent, while the raw material being also more conducive in same phase preferably plays synergistic effect between each other.

Detailed description of the invention

Fig. 1 is the preparation flow schematic diagram of the embodiment of the present invention；

Fig. 2 is the inoxidizability test result figure of the embodiment of the present invention.

Specific embodiment

To explain the technical content, the achieved purpose and the effect of the present invention in detail, below in conjunction with embodiment and cooperate attached Figure is explained.

The embodiment of the present invention are as follows: a kind of mildy wash of choline cloves hydrochlorate is prepared: molten by the component of following parts by weight Agent: 31.73 parts of deionized water；Conditioner: 3 parts of NaCl (sodium chloride), 0.02 part of essence (can select, this example makes according to hobby The daily essence Christian Dior for being available from Yu Chenyou company spends the HF-20286 that ripples)；Moisturizer: 10 parts of glycerol, Neosorb 15 Part, (60%) 8 part of sodium lactate；Surfactant: 18 parts of sodium lauroyl glutamate (BAFEORII GPW100), alkyl glycosides (APG1214) 4 parts；Pearling agent: 9 parts of lauric acid sodium taurocholate (BAFEORIITGL)；Thickener: poly bis stearate (DM638) 1 part；Preservative: methylisothiazolinone and 0.1 part of 0.15 part of Sensiva SC50 (K220) and choline cloves hydrochlorate.

It prepares raw material by above-mentioned and is divided into A, B, C, D and E phase raw material by following table 1 rule:

The separate classification chart of 1 raw material of table

Above-mentioned mildy wash preparation method, as shown in Figure 1, comprising the following steps:

Step 1): with pure hot water washing and sterilizing emulsion pot；

Step 2): emulsion pot is added in A phase raw material, high-speed stirred is evenly dispersed completely；Wherein, alleged high-speed stirred can adopt With 300-600rpm, the present embodiment mixing speed is 450rpm.

Step 3): being warming up to 85 DEG C under uniform stirring, then insulated and stirred 30 minutes is with sterilizing；

Step 4): being cooled to 60 DEG C or so slowly under uniform stirring, emulsion pot is added in B phase raw material, and continue to stir To being uniformly dispersed；

Step 5): being cooled to 45 DEG C, and C phase raw material is added, stirs evenly.

Step 6): 40 DEG C are cooled to hereinafter, addition D phase raw material, stirs evenly.

Step 7): E phase raw material is added, stirs evenly.

Step 8): stop stirring, cooling and then inspection and wait discharging；

Step 9): sealing storage vat after discharging, and moves between standing for use.

Step 10): semi-finished product dispense after quality inspection is qualified；

Step 11): packaging coding obtains finished product, is put in storage.

Wherein, the testing result in step 8) is as shown in table 2 below:

2 testing result table of table

As can be seen from Table 2, mildy wash made from the present invention program is safe and reliable.

The choline cloves hydrochlorate and vitamin A, vitamin C, vitamin E and syringic acid for taking equivalent carry out inoxidizability survey Examination:

Utilize external 1,1- diphenyl -2- trinitrophenyl-hydrazine (1,1-Diphenyl-2-picrylhydrazyl Radical2,2-Diphenyl-1- (2,4,6-trinitrophenyl) hydrazyl, DPPH) radicals scavenging experiment (weigh A certain amount of DPPH is configured to the DPPH solution of 0.04mg/mL with dehydrated alcohol.2mL various concentration (2,4,6,8mg/ is taken respectively ML 2mL DPPH solution is added in solution), is uniformly mixed, and after being placed at room temperature for 30min, 5000r/min is centrifuged 10min.Take supernatant Liquid surveys light absorption value at 517nm.) inoxidizability of choline cloves hydrochlorate is measured, and itself and vitamin A, vitamin C, dimension are given birth to The antioxygenic property of plain E is compared, and the IC50 value that experiment test obtains is lower, indicates that inoxidizability is stronger.IC50 value such as Fig. 2 Shown, the inoxidizability of choline syringic acid is between vitamin C and vitamin E, and about than the inoxidizability of monomer syringic acid It is strong by 25%.According to common knowledge it is found that vitamin A, vitamin C, the stability of vitamin E are poor, and choline fourth of the invention Choline cloves hydrochlorate, so that its stability enhances, therefore, is added to cosmetics due to interionic interaction force by fragrant hydrochlorate In can not only obtain good stability, simultaneously, moreover it is possible to obtain excellent inoxidizability.

Mildy wash made from above-described embodiment is subjected to anti-acne effect (bactericidal properties) test:

It will need to carry out 15 volunteers of anti-acne test, compliance test result carried out using product of the present invention mildy wash, specifically , anti-acne effect tracking is carried out to 15 volunteers in 3 months between on June 10,10 days to 2018 March in 2018 and is examined It examines, every volunteer is sooner or later primary using the progress of mildy wash made from aforesaid operations face cleaning daily, and specific test result counts such as Shown in the following table 3.

3 clinical test results of table

By upper 3 experimental result of table it is found that carrying out face cleaning using choline syringic acid mildy wash of the invention, anti-acne effective percentage can Up to 100%, long-term to be used continuously, safe and efficient, anti-acne effect is good, and recurrence rate is low, and the invention is persistently used using user Product.

Deionization water as solvent in the face cleaning composition of milk, NaCl and essence make conditioner, and NaCl can increase cosmetics The viscosity of formula system acts on, and plays the role of convergence, Firm, and essence can promote the fragrance of the present invention program product, so that Spirit is more pleasant in user's use process, improves skin condition from mentally auxiliary；Glycerol, (solid) sorbierite, sodium lactate (60%) make moisturizer, BAFEORIITGL makees pearling agent, and BAFEORII GPW100, APG1214 make surfactant, DM638 Make thickener, K220 makees preservative, and syringic acid choline salt makees functional component (anti-oxidant anti-inflammatory)；The water of BAFEORII GPW100 Solution is in subacidity, it is possible to provide flexible foam can avoid dry skin, tight feeling after washing, so that the skin after washing moistens Sliding, pure and fresh, APG1214 performance is mild, small to human body stimulation, has the function of softness to skin, blistering is abundant, with BAFEORII GPW100 compounds the cleaning action that can have both enhanced BAFEORII GPW100, meanwhile, it can also assist thickening.The gallbladder of the present invention program Alkali cloves hydrochlorate not only has good dissolubility, but also with good stability, when avoiding individually addition choline, stability Difference, when individually adding syringic acid, the two fold problem of dissolubility difference.

Above scheme selects two kinds of comparatively mild surfactants of BAFEORII GPW100 and APG1214, guarantees While face cleaning dynamics, reduce the irritation to skin, meanwhile, the choline cloves hydrochlorate of addition advantageously reduces other components To the irritation of skin, meanwhile, also make the product while face cleaning, it being capable of skin care moisturizing and can be anti-oxidant, anti-simultaneously Inflammation and antianaphylactic effect.

Above-described embodiment illustrates for for mildy wash, but the present invention program can also be used for other similar having face cleaning effect Cosmetics in.

The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair Equivalents made by bright specification and accompanying drawing content are applied directly or indirectly in relevant technical field, similarly include In scope of patent protection of the invention.

Claims (10)

1. a kind of cosmetics containing choline cloves hydrochlorate, it is characterised in that: the raw material for preparing of the cosmetics includes with the following group Point: choline cloves hydrochlorate, solvent, conditioner, moisturizer, surfactant and thickener.

2. the cosmetics according to claim 1 containing choline cloves hydrochlorate, it is characterised in that: the choline cloves hydrochlorate It is 0.01~5% preparing the weight ratio in raw material.

3. the cosmetics according to claim 1 containing choline cloves hydrochlorate, it is characterised in that: the choline syringic acid The ratio between salt, solvent, conditioner, moisturizer, surfactant and parts by weight of thickener are as follows: (0.01~5): (25~35): (2~5): (30~40): (15~25): (0.1~3).

4. the cosmetics according to claim 1 or 2 or 3 containing choline cloves hydrochlorate, it is characterised in that: the solvent is Water；The conditioner includes sodium chloride and essence；The moisturizer includes glycerol, sorbierite and sodium lactate；The surface-active Agent includes sodium lauroyl glutamate and alkyl glycosides；The thickener includes poly bis stearate.

5. the cosmetics according to claim 1 or 2 or 3 containing choline cloves hydrochlorate, it is characterised in that: the preparation is former Material further includes pearling agent.

6. the cosmetics according to claim 1 or 2 or 3 containing choline cloves hydrochlorate, it is characterised in that: the preparation is former Material further includes preservative.

7. the cosmetics according to claim 1 or 2 or 3 containing choline cloves hydrochlorate, it is characterised in that: the cosmetics For skin care item.

8. the cosmetics according to claim 6 containing choline cloves hydrochlorate, it is characterised in that: the skin care item are face cleaning Cream.

9. a kind of preparation method of the cosmetics as described in claim 1 containing choline cloves hydrochlorate, it is characterised in that: described Solvent is water；The conditioner includes sodium chloride and essence；The moisturizer includes glycerol, sorbierite and sodium lactate；The table Face activating agent includes sodium lauroyl glutamate and alkyl glycosides；The thickener includes poly bis stearate；

Raw material will be prepared and be divided into A, B, C, D and E phase, A phase raw material includes water, sodium chloride, glycerol and sorbierite；B phase raw material includes Sodium lauroyl glutamate, C phase raw material include alkyl glycosides and poly bis stearate, and D phase raw material includes sodium lactate, E phase raw material packet Include choline cloves hydrochlorate and essence；

As follows prepared by step:

After S1, the processing that carries out disinfection to emulsion pot, A phase raw material is added, stirring to all the components is uniformly dispersed；

80~90 DEG C are warming up under S2, uniform stirring, 20~40min of insulated and stirred；

S3, it is cooled to 50~65 DEG C under uniform stirring, B phase raw material is added, and it is uniform to B phase stock dispersion to continue stirring；

S4,40~45 DEG C are cooled to, C phase raw material is added, stirs evenly；

S5,40 DEG C are cooled to hereinafter, addition D phase raw material, stirs evenly；

S6, E phase raw material is added, stops stirring after mixing evenly, cools down up to the cosmetics.

10. the preparation method of the cosmetics according to claim 9 containing choline cloves hydrochlorate, it is characterised in that: described Cooling operation in step S3 is the speed stirring cooling with 1-3 DEG C/min.