JP2000247892A - Preparation composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation composition excellent in sterilizing property and mildewproof property and having high safety to use by including a specific electroreductive ionic water or its gel-like substance. SOLUTION: This preparation composition comprises a specific electroreductive ionic water [e.g. Multicleaner S-100 and GE-100(R) or the like] or its gel-like substance. The composition is prepared as cosmetic (e.g. skin cream, facial cleansing cream, make-up milky lotion, skin lotion or liquid cosmetic), quasi-drug (e.g. bathing agent, sun-screening agent, body odor-preventing agent, mouth refringerant, hair growing agent or medicinal dentifrice) or medicine (e.g. aerosol, solution, eye ointment, suspension or emulsion). Dosage form of the composition can be formulated as cream, ointment, milky lotion, gel or liquid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to pharmaceutical compositions such as cosmetics, quasi-drugs, and pharmaceuticals.

[0002]

2. Description of the Related Art Water is generally used for preparing cosmetics, quasi-drugs, pharmaceuticals and the like. Normally, tap water, well water,
Spring water, purified water, etc.

[0003]

These waters are most often used together with water-soluble or oil-soluble organic substances in the preparation of pharmaceutical compositions. This organic substance is for utilizing its physiological activity, and is often an extract from animal organs or an extract from natural materials such as plant leaves, flowers, stems and roots.

[0004] Therefore, when a pharmaceutical composition containing such an organic substance is stored for a long period of time, the generation of microorganisms and fungi cannot be avoided. In order to prevent this, various bactericides and preservatives are generally blended in the preparation of the pharmaceutical composition.

[0005] However, some of the commonly used germicides and preservatives have not been confirmed to be sufficiently safe for the skin, and some users may have a skin irritation or allergic reaction. In some cases, it is not always safe, and it is important that cosmetics and the like used for a long period of time be sufficiently safe.

Although some pharmaceutical compositions do not contain any bactericide or preservative, the pot life after opening or opening is as short as about one week, which is a problem for consumers. In fact, it is in fact not possible to say that this pot life guarantees the complete safety of the pharmaceutical composition.

[0007] Therefore, a basic object of the present invention is to provide a pharmaceutical composition which is excellent in bactericidal and fungicidal properties and which is highly safe to use.

[0008]

Means for Solving the Problems The present inventors have developed a special alkali ion having a physical excess of electrons obtained by electrolyzing natural water and applying current and pressure using a special diaphragm device. "Multi-cleaner S-100" which is water and is sold by Nisseki Co., Ltd.
And GE-100 "is a non-toxic, highly safe, high-performance water that exhibits excellent detergency, has a sterilizing and fungicidal effect, and its effect lasts for a long time. Intensive studies were conducted to use these as water for preparing a pharmaceutical composition.

That is, when the influence of the above-mentioned ionic water on microorganisms was examined, it was found that the ionic water exhibited an excellent bactericidal effect against Escherichia coli, Pseudomonas aeruginosa, Salmonella, Staphylococcus aureus and the like. In addition, when the pH, oxidation-reduction potential and appearance change were observed for a long period of time, it was confirmed that no change over time was observed, and the beginning of the present invention was obtained.

[0010] Further, a plant extract and a silanol derivative are added to the above-mentioned ionic water to prepare a gel-like external preparation,
The appearance change, the number of general viable bacteria, and the number of E. coli were measured at room temperature for 3 months. As a result, it was confirmed that there was no change in the appearance, and that there was a significant bacteriostatic effect even in the measurement of the viable cell count.

Further, it has been confirmed that various oils can be emulsified and dispersed without using any surfactant when the oil is added to the above-mentioned special electrolytic reducing ionic water and stirred. Was found to be extremely useful.

In addition to the above tests, the above-mentioned special electrolytic reducing ionic water used in the preparation of the pharmaceutical composition according to the present invention was also examined for its detergency, deodorant effect, antistatic effect and the like. These also exhibited excellent effects, and were found to be extremely useful as water for preparing pharmaceutical compositions.

[0013] In the above-mentioned special electrolytic reducing ionic water, S-100 is a liquid, and GE-100 obtained by partially changing the manufacturing method of S-100 is in a gel state in a normal state. In addition, when vibration is applied, the viscosity decreases, and the liquid can be handled as a normal liquid. Therefore GE-
When 100 is used, a gel-like pharmaceutical composition can be prepared without adding any thickening component, and there is an advantage that there is no problem even if this pharmaceutical composition is filled in a spray-type container. It was confirmed that this was extremely useful in the formulation design.

Accordingly, the pharmaceutical composition according to the present invention is characterized by containing the above-mentioned special electrolytic reducing ionized water.

[0015] The pharmaceutical composition according to the present invention can be cosmetic, quasi-drug or pharmaceutical.

[0016] The dosage form of the pharmaceutical composition according to the present invention can be cream, ointment, emulsion, gel or liquid.

In the pharmaceutical composition according to the invention, "cosmetics" refers to those used to clean, beautify, increase the appeal, change the appearance or keep the skin or hair healthy of the human body. I do.

In the pharmaceutical composition according to the present invention, "quasi-drug" is used for the purpose prescribed in Chapter 1, Article 2, Paragraph 2 of the Pharmaceutical Affairs Law, and has a moderate effect on the human body. Is referred to.

In the pharmaceutical composition according to the present invention, "pharmaceuticals" refers to those intended to be used exclusively for diagnosis, treatment or prevention of human or animal diseases.

In the pharmaceutical composition according to the present invention, the term "cream" is an oil-in-water type, a water-in-oil type, a water-in-oil-in-water type or an oil-in-water-in-oil type emulsified and has a relatively high viscosity. The composition may contain inorganic or organic pigments whose safety is guaranteed.

The term "ointment" refers to an oily vaseline-like state containing little or little water, and is composed of an inorganic or organic substance whose safety is guaranteed. May be contained.

The term "emulsion" refers to an oil-in-water type, a water-in-oil type, a water-in-oil-in-water type or an oil-in-water-in-oil type which is emulsified and has relatively low viscosity and exhibits fluidity. However, this composition may contain an inorganic or organic pigment whose safety is guaranteed.

The term "gel-like" refers to a substance that is transparent or translucent and has a low viscosity having fluidity and a high viscosity having no fluidity.

The term "liquid" refers to a substance which is transparent or opaque and has almost no viscosity and is close to water.

The pharmaceutical composition in each of the above-mentioned states, and specific examples of cosmetic preparations include skin cream, face wash cream, lotion, lotion, serum,
Examples include makeup removers, liquid foundations, pressed powders, lipsticks, lip glosses, shampoos, body soaps, soaps, liquid detergents, rinses, treatments, and the like.

Specific examples of quasi-drug preparations include bath agents, sunscreen agents (creams, emulsions, lotions, packs, etc.), armpit deodorants, mouth fresheners, hair restorers, medicated toothpastes, permanent waving agents , Gel-like fragrance, bath cleaner, cleaning cotton, sterilizing detergent, contact lens preservative, eyeglass cleaner, insect repellent and the like.

Specific pharmaceutical preparations include aerosols, solutions, eye ointments, suspensions, emulsions, eye drops,
Ointments, poultices, liniments, lotions and the like can be exemplified.

The pharmaceutical composition according to the present invention is, of course, an additive conventionally used in cosmetics, quasi-drugs and pharmaceuticals, such as surfactants, animal and vegetable oils and fats, fatty acid esters, higher alcohols and higher fatty acids. , Polyhydric alcohols, waxes, synthetic or natural polymers, preservatives, pigments and dyes, fragrances, physiologically active substances, and the like can be used within a range that does not impair the effects of the present invention by blending them.

In this case, specific examples of the surfactant include sorbitan fatty acid esters, ethylene glycol fatty acid esters, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, and the like. Examples include lipophilic nonionic surfactants such as methyl glucoside fatty acid esters, alkyl glyceryl ethers, and trialkyl phosphoric acids. On the other hand, specific examples of the hydrophilic nonionic surfactant include, for example, polyglycerin fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid ester , Polyoxyethylene alkylphenyl ethers, polyoxyethylene / polyoxypropylene ethers, polyoxyethylene
Polyoxypropylene alkyl ethers, polyoxyethylene animal and vegetable fats and oils, polyoxyethylene cured animal fats, polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, fatty acid alkanolamides, polyoxyethylene methyl glucoside fatty acid esters, Examples include sucrose fatty acid esters, alkylamine oxides and the like. Specific examples of the anionic surfactant include, for example, fatty acid soaps, alkyl sulfates, alkyl ether sulfates, higher fatty acid amide sulfonates, alkyl phosphates, alkyl ether phosphates, and sulfosuccinic acid. Salts, alkyl sulfonates, alkyl ether carboxylate salts, acyl amino acid salts, olefin sulfonates and the like can be exemplified. Further, specific examples of the cationic surfactant include, for example, alkyltrimethylammonium salts, dialkyldimethylammonium salts, alkylbenzylammonium salts, alkylpyridinium salts, and alkylbenzethonium salts. Furthermore, specific examples of the amphoteric surfactant include, for example, imidazoline-based amphoteric surfactants, alkylbetaines, alkylaminoacetic acid betaines, sulfobetaines, amidobetaines, and the like.

Specific examples of animal and vegetable oils and fats include, for example, almond oil, avocado oil, apricot kernel oil, olive oil, drill oil, grape seed oil, tallow, beef bone marrow fat, wheat germ oil,
Rice bran oil, sasanqua oil, safflower oil, squalane,
Camellia oil, lard, rapeseed oil, sunflower oil, castor oil, horse oil, palm oil, palm kernel oil, pristane, jojoba oil, macadamia nut oil, mink oil, cottonseed oil, coconut oil, rosehip oil, ozokerite, cocoa butter And the like.

Specific examples of the fatty acid ester include isopropyl myristate, isopropyl palmitate, isostearyl isostearate, cetyl octanoate, butyl stearate, octyldodecyl myristate, butyl myristate, ethyl oleate, myristyl myristate, Cetyl palmitate, isocetyl myristate, isocetyl stearate, isostearyl palmitate, isocetyl isostearate, hexyl laurate, cholesteryl stearate, cetyl lactate, diethyl sebacate, diisopropyl sebacate, diisopropyl adipate, propylene glycol monocaprylate, Propylene glycol dicaprylate, glyceryl trioctanoate, glyceryl tricaprylate, glyceryl tribehenate, Riisosuterin trimethylolpropane trioctanoate pentaerythritol, it can be exemplified monostearate batyl like.

Specific examples of higher alcohols include, for example, lauryl alcohol, myristyl alcohol, cetyl alcohol, hexyldecanol, stearyl alcohol, oleyl alcohol, cetostearyl alcohol,
Examples thereof include batyl alcohol, serachyl alcohol, behenyl alcohol, octyl dodecanol, cholesterol, phytosterol, jojoba alcohol and the like.

Specific examples of higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid,
Oleic acid, behenic acid, 12-hydroxystearic acid, linoleic acid, linolenic acid, coconut oil fatty acid, castor oil fatty acid and the like can be exemplified.

Specific examples of polyhydric alcohols include, for example, ethylene glycol, propylene glycol, glycerin, butylene glycol, polyglycerins, trimethylolpropane, pentaerythritol and the like.

Specific examples of the wax include, for example, paraffin wax, microcrystalline wax, carnauba wax, candelilla wax, whale wax, rice bran wax, ceresin wax, beeswax, mokuro, montan wax, hardened castor oil, hydrogenated jojoba oil, hardened tallow, etc. Can be exemplified.

Specific examples of synthetic or natural polymers include, for example, polyvinyl alcohol, sodium polyacrylate, polyvinylpyrrolidone, carboxyvinyl polymer, high molecular weight polyethylene glycol, methylcellulose, carboxymethylcellulose, ethylcellulose.
Hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, microcrystalline cellulose, carboxymethyl starch, phosphorylated starch, gum arabic, alginic acid, albumin, casein, guar gum, carrageenan, agar, xanthan gum, collagen, dextran, starch, pectin, quince, etc. Examples can be given.

Specific examples of preservatives include, for example, methyl paraben, propyl paraben, isopropyl paraben, butyl paraben, phenoxyethanol and the like.

Specific examples of pigments and dyes include, for example, titanium oxide, zinc oxide, iron oxide, silicic anhydride, aluminum oxide, talc, kaolin, sericite, calcium carbonate, magnesium carbonate, calcium sulfate, magnesium sulfate, silica Inorganic pigments such as calcium silicate, magnesium silicate, aluminum silicate, hydroxyapatite, ultramarine, navy blue, carbon black, and metal soaps such as aluminum stearate and calcium stearate;
Metal powders such as aluminum powder, mica titanium, bismuth oxychloride, fish scale foil, pearl pigments such as pearl shell powder, organic pigments such as azo pigments, indigo pigments, phthalocyanine pigments, Red No. 201, Red No. 202 No., red 203
No., Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 218, Red No. 219
No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228
No., Red No. 401, Red No. 504, Red No. 405, Red No. 506, Orange No. 201, Orange No. 205,
Orange No. 206, Orange No. 207, Orange 401, Yellow 201, Yellow 203, Yellow 204
No. 1, yellow No. 401, blue No. 201, blue No. 204, green No. 202, tar dyes such as green No. 401, red No. 2,
Red No. 3, Red No. 102, Red No. 104, Red No. 106
No., Red No. 227, Red No. 230, Red No. 231, Orange No. 205, Orange No. 207, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Yellow No. 403, Yellow No. 407, Orange No. No. 205, orange color 207
No., Blue No. 1, Blue No. 2, Blue No. 404, Green No. 201
No., green No. 204, purple No. 401, black No. 401, etc., and natural pigments such as β-carotene, canthaxanthin, calsamine, rutin, cochineal, alizarin, chlorophyll, curcumin and the like.

[0039]

Next, the present invention will be described in more detail and specifically with reference to Test Examples and Examples (Formulation Examples). The appearance and the like of “S-100” in the special electrolytic reducing ionic water used in the following Test Examples and Examples are as follows. Appearance: Colorless transparent liquid Odor: None pH (20 ° C.): 12.0-12.4 Specific gravity (20 ° C.): 1.002 Iron: 1 ppm or less Arsenic: 0.05 ppm or less Lead: 0.05 ppm or less Phenols: 0 0.005 ppm or less General viable cell count: 100 / ml or less Coliform bacteria: not detected

Test Example 1 (Stability over time of S-100) S- as a test solution was placed in a 100 ml transparent glass bottle with a lid.
100 as well as alkaline ionized water 1 and 2 of other companies as a control solution, and these were left at room temperature.
H change, redox potential change and appearance change were measured daily. In addition, HORIBA, pH / 10N was used for pH measurement.
Using a meter and model F24, changes in appearance were visually observed, and no significant difference was observed among the three.
The change in H and the change in oxidation-reduction potential are as shown in Table 1 below, and it was found that S-100 was clearly milder than the competitors and was superior in stability.

[0041]

[Table 1]

Test Example 2 (Bacteriostatic action of S-100) As a test method, a commonly used "plate culture method" was used, and the storage temperature was set at 25 ° C. Sterile purified water was used as a control, and the viable cell count of the control was measured at the start of the test, and the value was used as the value at the start. The results are as shown in Table 2 below, and it was confirmed that S-100, which is the test water, was significantly superior in bacteriostatic action to any of the bacteria when compared to the control. Was.

[0043]

[Table 2]

Test Example 3 (Acute Toxicity Test) As an acute toxicity test of S-100, a fish toxicity test was carried out on medaka. The test conditions are as follows. Test fish: Medaka (average body length 3.0 cm, average body weight 0.24 g) Condition of acclimation: 14 days before the test, the animals were reared and acclimated under the same water quality (dilution water), temperature and lighting conditions as the test conditions.
The mortality rate of the test fish during the acclimatization period was 5% or less. Number of fish per group: 10 Fish temperature: 23 ± 1 ° C Lighting: 14 hours / day Test container: Round glass water tank Dilution water: Natural standing Tap water (pH 7.9) from which residual chlorine was removed by (1) Preparation of test water: Test water of each concentration was prepared by adding S-100 to dilution water. The control group contained only dilution water. Measurement: The behavior of the test fish in each test group was observed, and the number of deaths after 24, 48, 72 and 96 hours was recorded.

The S-100 concentration of the test water was 1000-10
Although it was set to 0000 ppm, the number of deaths in the test group and the control group was 0. Therefore, 0% mortality is 10
0000 mg / l or more, and 218.
Since it was 341 g / g or more, it was proved that S-100 exhibited substantially no toxicity.

Test Example 4 (detergency test) S-100 was used as test water, alkali ionized water of another company used in Test Example 1 was used as control water 1 and 2, and a commercially available kitchen mainly containing a surfactant was used. Detergent as a standard product,
These detergency was evaluated comparatively according to the detergency evaluation method of 7.2 (synthetic detergent for kitchen) of JIS K3362 (test method for synthetic detergent).

After washing for 3 minutes using a detergency tester (rotational speed 250 ± 10 rpm) equipped with a glass piece to which a standard stain (a mixture of beef tallow, soybean oil, monoolein and oil red) was attached, After rinsing for a minute, air dried at room temperature for 24 hours. Immerse the glass pieces in a chloroform solution, and the redness of the chloroform solution (the degree of dirt removal)
Was evaluated by visual comparison with the case where was treated with a standard product. The results are as shown in Table 3 below, and it was found that S-100 has a detergency almost equal to that of the standard solution.

[0048]

[Table 3]

Test Example 5 (Antistatic Effect) A sample water (100% polyester) which had been washed, rinsed, dehydrated and air-dried in accordance with the washing method No. 103 defined in JIS L0217 was used as a sample water (as test water). S-10
0, 20 m of alkaline ionized water 1 and 2 of other companies used in Test Example 1 as control water and commercially available pure water)
1 / m 2 was sprayed and dried with hot air (70 ° C.) for 1 hour.
Then humidify for 24 hours (temperature 20 ± 5 ° C, relative humidity 40)
% Or less) and sealed in a polyethylene bag to prepare a sample. The sample was placed in a rotary friction device and run on a drum at 60 ± 10 ° C. for 15 minutes. Take out the sample from the drum with the insulating glove, put it into the Faraday gauge of the charged electric charge measuring device, read the value V (v) of the potentiometer, and read the charged electric charge Q
(C) was determined. The static electricity charged on the sample is
Each time, static elimination was performed using a self-discharge static eliminator. The results are as shown in Table 4 below, and it was found that S-100 was excellent in antistatic effect.

[0050]

[Table 4]

Test Example 6 (Deodorizing Effect ) 1 g of sample water (S-100 as test water and alkaline ionized water 1 and 2 of other companies used in Test Example 1 as control water) was weighed into a container, The vessel was sealed, and 50 μl of methyl mercaptan was injected into the sealed vessel using a gas-tight syringe, and allowed to stand at room temperature with shaking. The gas in the container was injected into the gas chromatogram over time. A blank test was performed in the same manner, the peak height on the obtained gas chromatogram was measured, and the residual ratio at each measurement time of the sample was measured using the blank as 100. The results are as shown in Table 5 below, and it was found that S-100 was extremely excellent in deodorizing effect.

[0052]

[Table 5]

[0053] Example 1 (Lotion) prescribing wt% S-100 77.0 1,3- butylene glycol 10.0 Polyoxyethylene (10) sunflower oil 2.0 (trade name: FLORASUN PEG-10, FLORATECH ) Polyoxyethylene (20) oleyl ether 1.0 Ethanol 10.0 Perfume

Preparation method: Components other than ethanol and S-100 are mixed and heated with stirring to make uniform. Ethanol was added to this, added sufficiently, and mixed well.
100 is further added and mixed to form a uniform solution.

[0055] Example 2 (for anti-wrinkle cosmetic gel) prescribing wt% GE-100 82.0 1,3- butylene glycol 10.0 Hydroxyethyl cellulose 1.0 Soy protein hydrolyzate 3.0 (trade name: PHYLDERM VEGETAL C, GATTEFOSSE) Beech bud extract 5.0 (trade name: GATULINE RC, GATTEFOSSE)

Preparation method: Hydroxyethyl cellulose is dispersed in water and allowed to stand. The other ingredients are then added with gentle stirring.

[0057] Example 3 (Makeup Remover) prescribing wt% GE-100 88.0 POE (10 ) sunflower oil 2.0 (trade name: FLORASUN PEG-10, FLORATECH) Propylene glycol 10.0 Preparation: All Add ingredients and stir and mix until uniform.

[0058] Example 4 (nourishing cream) Recipe wt% POE (8) Beeswax 8.0 (trade name: APIFIL, GATTEFOSSE) isostearyl octyldodecyl myristate 10.0 isostearate 10.0 S-100 64.4 Carboxyvinyl polymer 0.2 (Product name: Carbopol 934, BF Goodrich) Sodium hydroxide (10% aqueous solution) 0.4 Beech extract 2.0 (Product name: GATULINE RC, GATTEFOSSE) Diethylene glycol monoethyl ether 5 .0

Preparation method: Carbopol is dispersed in water. While stirring, the aqueous solution of Carbopol heated to 75 ° C is added to the mixture of APIFIL and ester heated to 75 ° C. Next, an aqueous solution of sodium hydroxide is added to add p
Adjust H to about 7. Cool with stirring, add other ingredients at 30 ° C. and cool completely.

[0060] Example 5 (emulsion moisturizing) prescribing wt% POE (6) stearate, POE (20) and Sechirue 6.0 ether, POE (20) mixed compound with stearyl ether (trade name: Tefose 2000, GATTEFOSSE) Stearic acid 1.0 Glyceryl stearate 1.0 Isostearyl isostearate 6.0 Sunflower oil 4.0 (trade name: FLORASUN 90, FLORATECH) Dimethyl polysiloxane (100CS) 2.0 S-100 76. 8 Hydroxyethyl cellulose 0.2 Collagen 3.0 (Product name: PANCOGENE MARIN, GATTEFOSSE)

Preparation method: Hydroxyethyl cellulose is dispersed in water and allowed to stand. While stirring, the aqueous solution of hydroxyethyl cellulose heated to 75 ° C is added to the emulsifier heated to 75 ° C and the oil phase. Hold at 75 ° C for 2 to 3 minutes, cool with stirring, add other components at 30 ° C, and cool completely.

Example 6 (Liquid Foundation) Prescription weight% (A) S-100 60.2 Carboxymethylcellulose 0.3 Magnesium aluminum silicate 0.8 1,3-butylene glycol 10.0 (B) Talc 0 Titanium oxide 5.0 Bengala 0.5 Yellow iron oxide 1.5 Black iron oxide 0.1 (C) Jojoba ester 5.0 (trade name: FLORAESTERS 30, FLORATECH) Isopropyl palmitate 7.0 Tocopherol acetate 0.2 Cetanol 0.5 Stearic acid 2.5 Decaglycerin monooleate 1.2 Decaglycerin decaoleate 2.0 (D) Triethanolamine 0.4

Preparation: Heat Phase A S-100 to 75 ° C. CMC and magnesium aluminum silicate are previously mixed and added to heating S-100 with rapid stirring. The remaining components of phase A are pre-mixed and added to a S-100 solution containing CMC and magnesium aluminum silicate with gentle stirring and mixed at 75 ° C for 20 minutes. While stirring with a high-speed homomixer, add the phase B component to the phase A at 75 ° C. and stir for 30 minutes. Heat the C-phase component to 80 ° C with stirring and 80 ° C with gentle stirring
And gradually add to the A + B phase. After stirring for 20 minutes,
Allow to cool to 75 ° C. with stirring, then adjust the pH to about 7 by adding phase D ingredients and cool to room temperature.

Example 7 (W / O type foundation) Preparative weight% (A) Triglycerin diisostearate 2.0 Hardened castor oil 1.0 Liquid paraffin 14.0 Dimethyl polysiloxane 2.0 (B) Lipophilic treatment Titanium oxide 6.4 Yellow iron oxide 1.0 Bengala 1.0 Triglyceryl diisostearate 3.0 Liquid paraffin (C) S-100 68.6 Sodium carbonate 0.5 Magnesium sulfate 0.5

Preparation method: B phase components are kneaded and homogenized using three rolls (number of kneading: 3 times). Add Phase B ingredients to Phase A. With rapid stirring, the phase C component heated to 85 ° C. is added to the (A + B) phase heated to 85 ° C., and cooled with stirring.

Example 8 (Deodorant and antiperspirant) prescription weight% GE-100 54.0 Ethanol 30.0 Aluminum chlorohydrate 5.0 1,3-butylene glycol 10.0 Benzalkonium chloride solution 1. 0 Suitable amount of fragrance

Preparation method: Components other than ethanol and flavor are mixed and made uniform. Next, the fragrance and ethanol are added and mixed.

Example 9 (Essence for whitening) Prescription weight% GE-100 81.8 1,3-butylene glycol 5.0 Magnesium L-ascorbyl phosphate 3.0 Sodium metasulfite 0.2

Preparation method: Mix all components and homogenize with stirring.

Example 10 (gel ointment) Prescription weight% GE-100 81.0 Hydroxyethyl cellulose 1.0 Indomethacin 3.0 Propylene glycol 5.0 Diethylene glycol monoethyl ether 10.0

Preparation method: After dissolving hydroxyethylcellulose in GE-100, the remaining components are added, mixed and made uniform.

Example 11 (Liquid detergent for kitchen) Prescription weight% S-100 87.5 Alkyl ether sulfate 5.0 Coconut oil fatty acid diethanolamide 2.0 EDTA-2Na 0.5 Propylene glycol 5.0 Perfume Appropriate amount

Preparation: Mix all components and stir until uniform.

Example 12 (Bactericidal cleaning agent for bathroom) Preparative weight% S-100 94.0 Benzalkonium chloride solution 1.0 Polyoxyethylene alkyl ether 2.0 (trade name: Sophthalanol 90, Nippon Shokubai) Sodium metasilicate 3.0

Preparation: Mix all components and stir until uniform.

Example 13 (soap-type body detergent) prescription weight% lauric acid 3.0 myristic acid 7.0 palmitic acid 2.0 oleic acid 3.0 lauroyl diethanolamide 5.0 glycerin 20.0 hydroxylated Potassium 3.5 S-100 56.5 Fragrance appropriate amount Chelating agent appropriate amount

Preparation: Components other than potassium hydroxide and S-100 are mixed and stirred while heating, and then an aqueous solution of potassium hydroxide is added. Stir and cool until uniform.

Example 14 (Liquid body soap) Prescription weight% Sodium polyoxyethylene lauryl ether sulfate 30.0 Ammonium lauryl ether sulfate 15.0 Palm fatty acid diethanolamide 4.0 Sodium chloride 2.0 Plant extract 3.0 Chelate Agent appropriate amount S-100 46.0

Preparation method: Mix components other than plant extract,
Mix while heating to make uniform. Next, the mixture is cooled with stirring, and when it reaches room temperature, the plant extract is added and mixed.

Example 15 (Liquid bath agent) Prescription weight% polyoxyethylene (30) polyoxypropylene (6) 20.0 decyltetradecyl ether glycerin 25.0 sunflower oil 25.0 fragrance appropriate amount S-100 30. 0

Preparation method: Components other than S-100 were mixed,
Make uniform with stirring. While stirring this mixture,
Add -100 and mix.

Example 16 (Gel-like fragrance) Prescription weight% GE-100 74.5 Carbopol 940 0.5 Fragrance 5.0 Dye qs Ethanol 20.0 Triethanolamine qs

Preparation method: Carbopol is dispersed in GE-100 and allowed to stand. Components other than triethanolamine are added thereto, and the mixture is stirred to make it uniform. The pH is then adjusted to about 7 by adding triethanolamine.

[0084]

EFFECT OF THE INVENTION The pharmaceutical composition according to the present invention is S-100 and / or GE-100 which are special electrolytic reducing ionic water.
It contains. These S-100 and GE-100
Is a highly functional water having a long-lasting bactericidal and antifungal action, an oil emulsifying action, a washing action, a deodorant action, an antistatic action, etc., and is extremely excellent as water for preparing pharmaceutical compositions, such as an emulsifying action. Utilization eliminates the need to use a surfactant. In particular, GE-100 is in a gel state in a normal state, has a property of lowering its viscosity when vibrated to be in a liquid state, and has a property of immediately returning to a gel normal state when left to stand.
If -100 is used, a gel-like preparation can be prepared without using a special gelling agent.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/48 A61K 7/48 7/50 7/50 31/00 617 31/00 617A A61L 9/01 A61L 9/01 Q C11D 17/08 C11D 17/08 (72) Inventor Toshio Yamaguchi 3-10-27 Okisho, Showa-ku, Nagoya City, Aichi Prefecture Inside Nisseki Co., Ltd. (72) Inventor Masahiro Okajima 3-chome, Sakashitacho, Kasugai-shi, Aichi Prefecture 450 F-term in AI System Products Co., Ltd. AC242 AC252 AC352 AC402 AC542 AC642 AC692 AC782 AD052 AD092 AD162 AD282 AD412 AD432 AD512 AD642 AD652 CC01 CC04 CC05 CC12 CC 17 CC23 CC25 CC29 DD22 DD32 DD41 EE01 4C086 AA01 AA02 HA30 MA01 MA04 MA16 MA22 MA28 MA34 ZB35 4H003 AB31 AC13 BA12 BA15 DA02 EB16 ED02 ED28 FA01 FA16 FA21 FA27 FA34

Claims (3)

[Claims] 1. A pharmaceutical composition comprising special electrolytic reducing ionic water or a gel-like substance thereof. 2. The pharmaceutical composition according to claim 1, which is a cosmetic, a quasi-drug, or a pharmaceutical. 3. The dosage form according to claim 1, wherein the dosage form is cream, ointment, emulsion, gel or liquid.
5. The pharmaceutical composition according to item 1.