JP2010100606A - Lotion - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a lotion utilizing electrolytically reduced water based on the finding that electrolytically reduced water is effective for curing burns. <P>SOLUTION: A lotion using electrolytically reduced water is prepared. The curing effect of the lotion for burns is studied. Third degree burns are caused on the skin of the back of mice. The electrolyzed water lotion is applied on the burns region (once a day) immediately after the burns are caused. When comparison is made between the group applied with the electrolyzed water lotion ((+) group) and the group applied with a physiological saline lotion ((-) group) as a control group on the burns region, a significant reduction in the injured area is observed in the (+) group. Further, histologic findings are that tissue spaces, blood vessels and lymphatic vessels are much observed in the subcutaneous tissue of the (-) group, whereas little in the subcutaneous tissue of the (+) group. The results above shows the electrolyzed water lotion is effective for curing burns region over the control and indicates the electrolyzed water lotion may possibly promote to heal burns region. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a coating agent containing electrolytic reduced water.

  Conventionally, coatings containing chemicals have been used for the treatment of burns and atopy and have achieved predetermined results.

However, there are many cases in which symptoms containing chemicals are unsuitable for some people and the symptoms worsen if the treatment method is wrong.
Therefore, an object of the present invention is to provide a coating agent that is harmless to all people and that exhibits excellent efficacy as a therapeutic agent for burns and atopy.

The coating composition according to claim 1, which is an invention made to achieve the above object, is characterized by containing electrolytic reduced water having a pH (hydrogen ion concentration index) of 10.5 to PH14.
This coating is natural water that has only a high PH value and is reduced by electrolysis. In addition, this coating agent showed an excellent improvement effect when it was applied to the affected area of burns and atopy by treatment.

  Therefore, the coating agent described in claim 1 is harmless to all since natural water is used, and can be used as a coating agent that exhibits excellent efficacy as a treatment for burns and atopy. .

The PH value of the electrolytically reduced water is more preferably 11.5 to 12.5, and most preferably 12.
By the way, the surface tension of natural water at room temperature (15 ° C. to 20 ° C.) is generally 70 dyn / cm or more, and as the electrolytic reduced water, the surface tension is 70 dyn / cm or less as described in claim 2. It is preferable to use one. This is because when the surface tension is small, the electrolytic reduced water penetrates smoothly into the affected area, and is effective in improving the affected area.

  In addition, as electrolytic reduction water, as described in claim 3, it is more preferable that the surface tension is 62 dyn / cm or less (corresponding to the surface tension of hot water of 80 ° C. or more). Thus, the surface tension is more preferably 58 dyn / cm or less.

Next, as described in claim 5, the coating agent of the present invention is preferably one obtained by gelling electrolytically reduced water using a gelling agent.
However, since the efficacy cannot be maintained if the PH value of the electrolytically reduced water is lowered, the gelling agent described in claim 6 can be used as a gelling agent capable of stably maintaining the PH value of the electrolytically reduced water. preferable. Specifically, as the gelling agent, it is possible to use a gelling agent for polyacrylates, celluloses, natural polymers, or a gelling agent used as a thickener for foods or a thickener for cosmetics. preferable.

  In addition, as a gelling agent capable of stably maintaining the pH value of electrolytically reduced water, it has been found by experiment that it is optimal to use sodium carboxymethylcellulose described in claim 7. As the coating agent of the invention, it is preferable to use carboxymethyl cellulose as a gelling agent.

It is a graph (C) of a photograph (A) immediately after burn wound creation, a drawing of the measurement site (B), and a number of days after burn wound-wound area ratio. In the photograph of the wound part to which the lotion of the present embodiment was applied and (+), the photograph of the wound part to which the physiological saline solution of the comparative example was applied (−), 0, 3, 6, 8, The photograph of the 11th day is shown. The photograph of the wound part 3 days after the wound to which the lotion of this embodiment was applied and (+), and the photograph of the wound part 3 days after the wound to which the physiological saline solution of the comparative example was applied (-), respectively, It is a photograph of. 3A is a magnified photograph of 2 times the wound part, FIG. 3A1 is a magnified photograph of 10 times of the part surrounded by a square in FIG. 3A, FIG. 3A2 is a magnified photograph of 20 times of FIG. 3A, and FIG. It is a 30 times enlarged photograph. 3B is a magnified photograph of the wound part twice, FIG. 3B1 is a magnified photograph of 10 times of the part surrounded by the square in FIG. 3B, FIG. 3B2 is a magnified photograph of 20 times of FIG. 3B, and FIG. It is a 30 times enlarged photograph. 3A4 and 3B4 are photographs showing the thickness of the skin directly under each wound. It is an enlarged photograph of the blood vessel near the injury on the third day from the wound.

Embodiments to which the present invention is applied will be described below with reference to the drawings.
[１． Overview of healing effect of lotion using electrolytically reduced water]
A lotion (corresponding to the coating agent of the present invention) containing electrolytically reduced water (hereinafter, electrolyzed water) was prepared, and the healing effect of burn wounds in the lotion was examined. First, a third degree burn wound was created on the back skin of the mouse, and immediately after the wound, an electrolyzed water lotion and a lotion containing physiological saline (hereinafter, saline) as a control were applied to the burn wound site (once a day). Then, the wound area was measured over time, and histological examination of the burn wound site (day 3) was performed. When comparing the wound wound site with the group to which the electrolyzed water lotion was applied ((+) group) and the group to which the saline lotion was applied ((−) group), the wound area was significantly reduced in the (+) group. . Furthermore, as histological findings, many tissue gaps and blood vessels / lymph vessels were confirmed in the subcutaneous tissue of the (−) group, but there were few in the (+) group. From the above results, the electrolyzed water lotion was found to be more effective in healing the wound wound site than the control, suggesting the possibility of promoting the healing of the burn wound.

[2. About wound treatment]
Wound healing refers to a phenomenon in which a tissue damaged by trauma or the like is destroyed, and a regeneration or repair reaction occurs on the lost tissue or cell. Injuries include cuts, wounds, stab wounds, burns and chemical damage. A series of biological reactions in which a living body tries to recover and reconstruct the tissue itself and functions lost by such a mechanism are called wound healing.

  Among them, burns are a state in which the skin is damaged by heat, and is roughly classified into three according to the degree. Level I burns are skin surface damage, Level II burns are damage to the dermis and are accompanied by edema. A third-degree burn is an injury that extends to the dermis and even to the subcutaneous tissue, and scars often remain after healing. In the past, treatment of II and III burns has mainly been performed using topical therapies (such as disinfectants such as isodine, steroid-containing ointments, antibiotic-containing ointments, etc.) to suppress wound infection. We have been using various wound dressings (polyurethane films, hydrocolloids, polyurethane foams and hydrogel dressings, alginate dressings, hydropolymers, etc.) to make the most of the healing action of living bodies. It has changed to therapy.

  These topical therapeutic agents and wound dressings play important roles in the damaged area, such as promoting epithelialization, preventing infection, and reducing pain. Recently, basic fibroblast growth factor (bFGF) preparations have been clinically applied and are effective in shortening the wound healing period.

[3. About electrolytically reduced water]
The special electrolytic reducing water used in the present embodiment (hereinafter abbreviated as electrolytic water: corresponding to the electrolytic reduced water of the present invention) is physically obtained by treating natural water by electrolysis, energizing and pressurizing. It is an electron-excess water, and it is known to show cleaning, deodorizing, sterilizing and dust-proofing effects because it is removed by the action of exfoliating dirt and bacteria that cause odors due to special alkaline properties and negative ions. (Trade name S-100: manufactured by AI System Product Co., Ltd.). It also has rust and antiseptic effects to prevent oxidation. Furthermore, it has also been found that an emulsifying action by electrolyzed water alone is shown without adding an emulsifier. Utilizing these properties, they are now widely used as cleaning solutions for various industrial products.

  Specifically, the electrolyzed water used in the present embodiment is a deoxygenation process in which deoxygenation treatment is performed to reduce dissolved oxygen in pure water to 1 ppm or less, and the pure water that has undergone deoxygenation treatment in this deoxygenation process. An electrolysis process for electrolyzing water containing an electrolyte such as a small amount of sodium chloride, and among the water electrolyzed by this electrolysis process, the water on the cathode chamber side is 4 kg / kg in a sealed stabilization tank. It is manufactured by treating the water through a stabilization step of stabilizing by applying a pressure of cm 2 or more.

As a chemical property, the electrolyzed water used in this embodiment is stable at PH12.
The hydrogen ion concentration index of the electrolyzed water is not limited to PH12, but may be stabilized at PH10.5 to PH14, and more preferably at PH11.5 to PH12.5.

  As other chemical properties, the electrolyzed water used in the present embodiment has a surface tension of 56.1 dyn / cm (surface tension meter: BPA-manufactured by Max Planck Institute of Colloids and Interfaces, Germany) 800P model).

  If the surface tension of the electrolyzed water is smaller than the surface tension of natural water at room temperature (70 dyn / cm or more), the effect of penetrating into the affected area is seen. Therefore, the surface tension is preferably 70 dyn / cm or less, and 62 dyn / cm or less. Furthermore, it is more preferable that it is 58 dyn / cm or less.

The surface tension of the electrolyzed water may be in the range of 29 to 62 dyn / cm, 55 to 58 dyn / cm, and more preferably 56.1 dyn / cm.
In this embodiment, in order to examine the application of this electrolyzed water to pharmaceuticals, the effect of promoting healing in burn wounds was examined using electrolyzed water.

[4. Study method]
<4.1. Handling animals>
In this study, a total of 20 ddy male mice aged 7 to 10 weeks were used.

<4.2. Experimental Materials>
As the electrolyzed water, electrolyzed water S-100 manufactured by AI System Product Co., Ltd. was used. Moreover, all the various reagents used special grades.

<4.3. Preparation of electrolyzed water and saline lotion>
Electrolyzed water and saline lotion were prepared in a dispersion medium (electrolyzed water or saline) by adding sodium carboxymethylcellulose (Kanto Chemical Co., Ltd.) as a gelling agent with stirring to a final concentration of 7%.

<4.4. Burn wound creation method>
Under anesthesia by intraperitoneal injection of sodium pentobarbital (Nacalai Tesque), the back of the mouse was shaved with an electric clipper with reference to the reports of Hashimoto et al. And the III degree burn wound was created by applying the iron tip of the electric iron (made by Hakumitsu Co., Ltd.) heated to 300 degreeC to the back part for 5 seconds. The electric iron was applied uniformly to the side of the iron tip so that the pressure at the time of wound creation was constant. In addition, in order to avoid the heterogeneity of the experiment as much as possible, the same experimenter created the wound.

<4.5. Measurement of burn wound area>
After creating burn wounds for 14 mice, 7 mice were divided into 2 groups.
And it was set as the group ((+) group) which apply | coated the electrolysis water lotion, and the group ((-) group) which apply | coated the saline lotion, respectively. First, immediately after the wound was created, the wound site was photographed with a digital camera (Day 0). After wound preparation, electrolyzed water and saline lotion were applied to each group once a day, and photographs were taken on days 1, 2, 3, 6, 8, 10, 11, 13, and 15. And the wound area was measured for the image data obtained with the digital camera using software Image J (Bioarts Corporation). Taking the measurement value on the wound creation date as 100%, the ratio (%) of the wound area on each measurement day was determined, and the healing effect of the electrolyzed water lotion was examined.

<4.6. Histological examination>
A burn wound was created in the same manner by applying an electric iron to one back of six mice.
Divided into 2 groups of 3 animals, electrolytic water and saline lotion were applied to each group once a day. Three days after the creation of the wound, it was sacrified under inhalation anesthesia with diethyl ether, and the skin including the tissue around the wound was removed. After immersion and fixation with 20% neutral buffered formalin solution for pathological examination (Kanto Chemical Co., Inc.), 4 μm thick paraffin sections were prepared, and hematoxylin and eosin staining (hereinafter referred to as HE staining) was applied. Was made. Thereafter, each specimen was photographed using an optical microscope, and the tissue was observed. The preparation and evaluation of tissue specimens were commissioned to the Institute for Tissue Science.

<4.7. Observation of blood vessels near wound>
Six mice used in the histological evaluation were sacrified three days after the creation of the burn wound, and after removing the back skin, the state of the capillary in the subcutaneous tissue was confirmed.

<5. Result>
In this experiment, we examined the healing effect on burn wounds using electrolyzed water lotion to examine its application to pharmaceuticals. As a general index for evaluating wound healing, days until the completion of another epithelialization and wound area are used.

Therefore, in this experiment, after creating a third degree burn on the dorsal skin of the mouse, the wound area was measured over time, and compared with a case where a saline lotion was applied as a control.
<5.1. Time course of wound area>
FIG. 1 shows a photograph (A) immediately after creation of a burn wound and a drawing (B) depicting a measurement site. In FIG. 1B, a portion surrounded by an ellipse is a portion that is in contact with the electric iron, and is a portion determined to be a wound.

  FIG. 1C shows a graph of the number of days after burn wound-wound area ratio. From this graph, when the wound area on the wound creation day is set to 100% and the measurement ratio of each measurement day is compared, it can be seen that the (+) group is significantly smaller than the (−) group at the time of measurement excluding the first day. . In the (−) group, no tendency to shrink the wound was observed until 2 days after the injury, but the (+) group showed a tendency to shrink from the second day.

<5.2. Transition of healing after burn wound creation>
As shown in the photograph of FIG. 2, after creating the burn wound, electrolytic water and saline lotion were applied to each group once a day, and photographs were taken on the 0th, 3rd, 6th, 8th, and 11th days. And the wound site | part of the (+) group and the (-) group was compared.

As a result, the healing effect of the (+) group was clearly recognized as compared with the (−) group from the 6th day. Furthermore, on the 11th day, the (+) group was almost completely cured.
<5.3. Skin tissue image 3 days after burn creation>
1) Microscopic examination around the burn wound The whole image (2 times) of the wound site cross section after HE burn (hematoxylin and eosin stain) 3 days after the burn wound treatment was shown (FIG. 3AB). FIG. 3A and FIGS. 3A1 to A3 are photographs of the (+) group in which electrolytic water lotion is applied. FIG. 3B and FIGS. 3B1 to B3 are photographs of the (−) group, in which a saline lotion is applied. As a comparative example, FIGS. 3C1 to C2 are photographs of “normal sites”, showing sites where no abnormality is seen in the epidermis or appendages. Moreover, the arrowhead mark shown in the photograph represents the center of the wound site, Epi represents the epidermis, Der represents the dermis, SC represents the subcutaneous tissue, and CM represents the skin muscle.

  Regarding the (+) group, an enlarged (10 times) portion indicated by □ in FIG. 3A (left side edge of the wound site) is A1, and further, an enlarged image of the epidermis side of the wound site of A1 (20 times) A3 is an enlarged image (20 times) of the subcutaneous tissue side of the wound sites A2 and A1.

  Similarly, with respect to the control (-) group, an enlarged (10 times) portion indicated by □ in FIG. 3B (left side edge of the wound site) is B1, and further, the epidermis of the wound site of B1 The side magnified image (20 times) is B2 and the subcutaneous tissue side magnified image (20 times) of the wound site of A1 is B3.

  Further, an enlarged (10 times) normal skin tissue site is C1, and further, an epidermis side enlarged image (20 times) of the wound site of C1 is a subcutaneous tissue side enlarged image (20 times) of the wound sites of C2 and C1. C3.

  In the subcutaneous tissue (SC) of the wound site of the (−) group, many portions not stained with HE staining were observed (FIG. 3B1). This indicates that there are many tissue gaps, blood vessels and lymphatic vessels, and the staining is dense in the (+) group, suggesting that the wound is minor compared to the (−) group ( FIG. 3A1).

2) Microscopic examination directly under the wound wound When comparing the thickness of the skin directly under the wound with that of normal skin, the (-) group showed deformation in the epidermis and dermis, but no significant difference was observed as in the (+) group. (FIG. 3A4, B4). In addition, it was observed that inflammatory cells (mainly neutrophils) stained blue-purple with HE staining were more infiltrated just below the (+) and (−) wounds.

<5.4. Blood vessel in subcutaneous tissue 3 days after burn creation>
The blood vessels near the wound were confirmed from the subcutaneous tissue side. FIG. 4 is an enlarged photograph of a blood vessel near the damage. As shown in FIG. 4, blood vessels were confirmed in the burn wound and the surrounding area as compared with the (+) group in the (−) group.

[4. Discussion]
In order to confirm the wound healing of electrolyzed water, the effect of applying electrolyzed water on the wound surface was examined. Initially, electrolyzed water was applied as it was, but it dried quickly and the moist environment could not be maintained. In order to maintain the moist environment of the wound surface, preparation of an ointment and the use of a covering material were also examined, but in order to make it easier to observe changes over time of the wound surface, it is transparent and viscous, and itself has a pharmacological action. A lotion dosage form was prepared using sodium carboxymethylcellulose (hereinafter abbreviated as CMC-Na). This CMC-Na is a pharmaceutical polymer that is also used as a coating material. It is easily dissolved in water and has properties such as viscosity, stability and protective colloid properties. Many are used. During the experiment, the dosage form of a viscous lotion was used to keep the electrolyzed water at the burn wound site for a long time, thereby maintaining the healing effect.

  After the injury, electrolyzed water and saline lotion were applied once a day, respectively, and the mouse skin of the burn wound model was removed 3 days after the injury. Then, in order to examine the effect of electrolyzed water histopathologically, HE-stained specimens were prepared and microscopically observed. In specimens applied with electrolyzed water and saline lotion, histologically third degree burns were observed. And when the tissue findings of both were compared, a clear difference was recognized (FIG. 3).

  First, regarding the histological findings of the specimen (-) applied with the raw saline lotion as a control, the epidermis of the burn wound part disappeared, and the entire dermis was in a state of coagulation necrosis to melting necrosis including the appendages. (FIG. 3B1-4). Furthermore, necrosis extended to the cutaneous muscle, and muscle fibers were severely melted, particularly in the central part of the burn wound. In the so-called “ulcer”, the ulcer portion was filled with necrotic tissue and exudate (scab) (FIG. 3B4). A large amount of nuclear decay products (positive for hematoxylin) were found in the dermal necrotic area. A marked inflammatory reaction was observed in the subcutaneous tissue at the bottom of the ulcer. In addition, the epidermis around the burn wound was thickened, and a reconstructed image of the epidermis (image where the new epidermis was sent to the defect) was observed at the boundary. In this area, inflammatory cell infiltration from the dermis to the subcutaneous tissue was remarkable, and the muscle line of the cutaneous muscle was atrophied.

  On the other hand, regarding the tissue findings of the specimens to which the electrolyzed water lotion was applied, coagulative necrosis occurred from the epidermis of the burn wound area to the entire dermis, but unlike the (−) group, the structure of the epidermis and appendages remained. (FIG. 3A1-4). Furthermore, although coagulative necrosis extends to the cutaneous muscle, it was less severe than the (−) group, and the structure of the myoline was maintained without falling into melting necrosis. A marked inflammatory reaction and an increase in granulation tissue were observed in the subcutaneous tissue at the center of the burn wound (FIG. 3A4). In addition, the epidermis around the wound was thickened, and a regenerated image of the epidermis was observed at the boundary portion, but the amount of the new epidermis fed to the defect portion was smaller than that in the (−) group. The inflammatory cell infiltration from the dermis to the subcutaneous tissue was slight, and the muscle fibers of the cutaneous muscle were atrophied.

  Next, blood vessels near the wound were confirmed from the subcutaneous tissue side (FIG. 4). On the third day of the injury, in the (−) group, capillaries could be confirmed at and around the damaged portion, but the (+) group was hardly observed. This is the stage of the third day of injury in FIG. 1C, and the (+) group tends to have a smaller wound area than the (−) group, and considering this, the (+) group is earlier in the third day of the injury. The possibility of a smooth transition from the inflammatory stage to the granulation stage was considered.

  As described above, when the effect of the therapeutic agent application on the mouse skin burn model was examined histopathologically, necrosis caused by electrolysis water lotion on wounds up to 3 days after injury was assumed on the premise that the degree of initial burn wound was equivalent. It was suggested that it has the effect of reducing changes and inflammatory reactions.

  Generally, the process of wound healing can be divided into three stages: an inflammatory stage, a granulation stage, and a remodeling stage. Three days after this injury, the inflammatory phase was intensified, and it was thought that cells such as neutrophils secreted phagocytosed cells and physiologically active substances such as cytokines.

  From the results of this experiment, the (+) group had less inflammatory cell infiltration from the dermis to the subcutaneous tissue compared to the (−) group, so electrolyzed water may have the property of keeping the inflammation process small ( FIG. 3A1, B1).

As a result of examining the effect of electrolysis water lotion on burn wounds, it was suggested that wound healing was promoted.
[5. Conclusion]
The wound healing effect of electrolyzed water lotion on the third degree burn wound was examined experimentally. As a result, it was suggested that electrolyzed water lotion is effective in improving burn wounds and may promote burn wound healing.

[6. Others]
<6.1>
In the above experiment, only the efficacy of burns is shown, but in other experiments, when the electrolyzed water lotion of this embodiment was applied to the affected area of the atopic disease, the affected area was not noticeable in about 2 weeks. Saw improved results.

<6.2>
It has been found that the electrolyzed water lotion of the present embodiment exerts a bactericidal action, but when the electrolyzed water lotion is hung on the periodontal bacteria taken out from the mouth, 99% of the periodontal bacteria are killed.

Moreover, it was found that the electrolyzed water lotion of this embodiment has an effect of neutralizing butyric acid when a few drops of electrolyzed water lotion are dripped onto butyric acid taken out from the mouth together with periodontal bacteria.
Butyric acid has a function of destroying leukocyte immune cells when it enters the body through the gums. By neutralizing butyric acid in the mouth with the electrolyzed water lotion of this embodiment, it is possible to protect the immune cells in the body. As a result, the immune cells in the body destroy cancer cells, AIDS virus, etc. in the body, so if the electrolyzed water lotion of this embodiment is used as a dental treatment or dentifrice, it will be used for the treatment and prevention of alveolar pyorrhea and dental caries. Not only does it become cancer treatment and prevention, it also treats and prevents AIDS.

<6.3>
Moreover, it is known from a storage experiment conducted separately from the above experiment that the electrolyzed water lotion of the present embodiment has a storage performance because the PH value does not change even after one year or more. That is, it has been found that the above-mentioned sodium carboxymethyl cellulose is most preferable as the gelling agent.

  However, if storage performance such as sodium carboxymethylcellulose is not required, gelling agents such as polyacrylates, celluloses, natural polymers, thickeners for foods, thickeners for cosmetics You may use the gelatinizer used as an agent.

As polyacrylates, polyacrylates and carboxyvinyl polymers are preferred.
As the cellulose, carboxymethylcellulose sodium salt, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose and the like are preferable.

  As natural polymers, xanthan gum, carrageenan sodium salt, sodium alginate, hydroxypropyl guar gum, gum arabic, tragacanth gum, guar hydroxypropyltrimonium chloride and the like are preferable.

  As the thickener for food, pectin, guar gum, xanthan gum, tamarind gum, carrageenan, propylene glycol, propylene glycol fatty acid ester, sodium carboxymethylcellulose (CMC) and the like are preferable.

  Cosmetic thickeners include pectin, gum arabic, arginine carbomer (carboxyvinyl polymer) / carbomer, sodium alginate / Na alginate, propylene glycol alginate / PG alginate, ethyl cellulose, sodium carboxymethyl cellulose / cellulose gum / sodium glycolate / CMC, xanthan gum, gellan gum, hydroxypropyl guar gum (HP guar), hydroxyethyl cellulose (HEC), cationized guar gum (guar hydroxypropyltrimonium chloride), locust bean gum, cationized cellulose (polyquaternium-10), synthetic sodium silicate Magnesium, dimethyl distearyl ammonium hectorite / quaternium-18 hectorite, B cyclodextrin / CD, sodium polyacrylate / polyacrylic acid Na, lauramide DEA, PEG-120 methyl glucose etc. dioleate preferred.

<6.4>
In the above embodiment, the electrolyzed water lotion has a concentration of 7% (weight ratio, electrolyzed water 93: CMC-Na7), but is not limited thereto. Of course, the concentration may be changed according to the application.

  The present invention is not limited to the above-described embodiment as long as it matches the gist of the invention described in the claims.

Claims (7)

A coating agent comprising electrolytic reduced water having a pH of 10.5 to PH14. The coating composition according to claim 1,
The electrolytically reduced water is
A coating agent having a surface tension of 70 dyn / cm or less. In the coating agent according to claim 2,
The electrolytically reduced water is
A coating agent having a surface tension of 62 dyn / cm or less. In the coating agent according to claim 3,
The electrolytically reduced water is
A coating agent having a surface tension of 58 dyn / cm or less.   The coating agent according to any one of claims 1 to 4, wherein the electrolytically reduced water is gelled using a gelling agent. In the coating agent according to claim 5,
The gelling agent is
Gelling agents for polyacrylates, celluloses, natural polymers,
Or
A coating agent characterized by being a gelling agent used as a thickener for foods and a thickener for cosmetics.   The coating agent according to claim 6, wherein the gelling agent is sodium carboxymethylcellulose.