JP5275532B2 - Formulation composition - Google Patents

Description

  The present invention relates to pharmaceutical compositions such as cosmetics, quasi drugs, and pharmaceuticals.

  When preparing cosmetics, quasi-drugs, pharmaceuticals, etc., water is generally used. The water usually used for preparing these pharmaceutical compositions is tap water, well water, spring water, purified water and the like.

Problems to be solved by the invention and objects of the invention

  These waters are most often used with water-soluble or oil-soluble organic substances in the preparation of pharmaceutical compositions. This organic substance is used for utilizing its physiological activity, and is often an extract from an animal organ or an extract from natural materials such as plant leaves, flowers, stems and roots.

  Therefore, in the case where a pharmaceutical composition containing such an organic substance is stored for a long period of time, generation of microorganisms and soot cannot be avoided. In order to prevent this, in the preparation of a pharmaceutical composition, it is usual to incorporate various bactericides and preservatives.

  However, some of the widely used disinfectants and preservatives cannot be said to have been sufficiently confirmed to be safe for the skin, and some users may exhibit skin irritation or allergic reactions. However, it is not always safe, and it is important that cosmetics and the like that are used for a long time are sufficiently safe.

  Some pharmaceutical compositions contain no bactericides or preservatives, but the pot life after opening or opening is as short as about one week, which is inconvenient for consumers. In addition, it is difficult to say that this pot life guarantees the complete safety of the pharmaceutical composition.

  Therefore, the basic object of the present invention is to provide a pharmaceutical composition which is excellent in bactericidal and antifungal properties and has high use safety.

Means for solving the problem

[Means for Solving the Problems]
The inventors of the present invention are special alkaline ionized water obtained by electrolyzing natural water and energizing / pressurizing using a special diaphragm device, and physically having excess electrons. " Product name: Multi-cleaner S-100 and GE-100" manufactured and sold by Niseki Co., Ltd., which is one of the company, is non-toxic, highly safe, exhibits excellent detergency, and has a sterilizing and antifungal effect In view of the fact that these are highly functional waters that have long-lasting effects, they have been intensively studied to use them as water for preparing pharmaceutical compositions.

  That is, as a result of examining the influence of the ionic water on microorganisms, it has been found that it exhibits an excellent bactericidal effect against Escherichia coli, Pseudomonas aeruginosa, Salmonella, Staphylococcus aureus and the like. Moreover, when pH, oxidation-reduction potential, and appearance change were observed over a long period of time, it was confirmed that no change over time was observed, and the beginning of the present invention was obtained.

  Furthermore, a plant extract and a silanol derivative were added to the above ion water to prepare a gel-like external preparation, and the appearance change, the number of viable bacteria, and the number of E. coli were measured over 3 months at room temperature. As a result, it was confirmed that there was no change in appearance and that there was a significant antibacterial effect in the measurement of the number of viable bacteria.

  Furthermore, it was confirmed that various oils can be emulsified and dispersed without using any surfactants after adding and stirring the oil in the special electroreductive ionic water described above, which is extremely useful in developing a formulation. It turned out to be.

  In addition to the above tests, the above-mentioned special electroreductive ionic water used for the preparation of the pharmaceutical composition according to the present invention was also examined for its detergency, deodorizing effect, antistatic effect, etc. An excellent effect was recognized, and it was proved that it was extremely useful as water for preparing a pharmaceutical composition.

  In addition, S-100 is a liquid in the above-mentioned special electrolytic reducing ion water, and GE-100 obtained by changing a part of the production method of S-100 is normally in a gel state, and vibrations. When applied, the viscosity decreases and it can be handled as a normal liquid. Therefore, when GE-100 is used, a gel-like pharmaceutical composition can be prepared without adding any thickening component, and there is no problem even if this pharmaceutical composition is filled in a spray container. It was confirmed that it has an advantage, and it was suggested that it is extremely useful in the formulation design.

  Therefore, the pharmaceutical composition according to the present invention is characterized by containing the above-mentioned special electrolytic reducing ion water.

  It can be a cosmetic, quasi-drug or pharmaceutical product of the pharmaceutical composition according to the invention.

  The dosage form of the pharmaceutical composition according to the present invention can be cream, ointment, emulsion, gel or liquid.

  In the pharmaceutical composition according to the present invention, “cosmetics” refers to those used to cleanse, beautify, enhance attractiveness, change the appearance or keep the skin or hair healthy.

  In the pharmaceutical composition according to the present invention, the “quasi-drug” is used for the purpose stipulated in Article 2, Paragraph 2 of Chapter 1 of the Pharmaceutical Affairs Law, and refers to those that have a mild effect on the human body. .

  In the pharmaceutical composition according to the present invention, “pharmaceutical” refers to a substance intended exclusively for use in the diagnosis, treatment or prevention of human or animal diseases.

  In the pharmaceutical composition according to the present invention, “creamy” refers to an oil-in-water type, a water-in-oil type, a water-in-oil-in-water type, or an oil-in-water-in-oil type, which has a relatively high viscosity. In addition, the composition may contain an inorganic or organic pigment with guaranteed safety.

  “Ointment” refers to an oily petrolatum-like state that contains little or no water, and this composition contains an inorganic or organic pigment with guaranteed safety. Can be contained.

  “Emulsion” means an oil-in-water type, a water-in-oil type, a water-in-oil-in-water type, or an oil-in-water-in-oil type, which has a relatively low viscosity and exhibits fluidity. The composition may contain an inorganic or organic pigment with guaranteed safety.

  “Gel” refers to a transparent or semi-transparent liquid having a low viscosity to a high viscosity with no fluidity.

  “Liquid” refers to water that is transparent or opaque and has almost no viscosity.

Formulation compositions in each of the above states, and specific examples of cosmetic preparations include skin creams, facial creams, cosmetic emulsions, lotions, lotions, cosmetics, makeup removers, liquid foundations, pressed powders, lipsticks, Examples include lip gloss, shampoo, body soap, soap, liquid detergent, rinse, treatment and the like.

  Specific quasi-drug preparations include bath preparations, sunscreens (creams, emulsions, lotions, packs, etc.), anti-odor agents, mouth fresheners, blue hairs, medicated toothpastes, permanent wave agents, gels Examples include fragrances, bath cleaners, cleaning cottons, bactericidal cleaners, contact lens preservatives, eyeglass cleaners, insect repellents, and the like.

  Specific examples of pharmaceutical preparations include aerosols, solutions, eye ointments, suspensions, emulsions, eye drops, ointments, poultices, liniments, lotions and the like.

  Naturally, the pharmaceutical composition according to the present invention includes additives conventionally used in cosmetics, quasi-drugs and pharmaceuticals, such as surfactants, animal and vegetable oils and fats, fatty acid esters, higher alcohols, higher fatty acids, polyvalents. Alcohols, waxes, synthetic or natural polymers, preservatives, pigments and dyes, fragrances, physiologically active substances, and the like can be used within a range that does not impair the effects of the present invention.

  In this case, specific examples of the surfactant include, for example, sorbitan fatty acid esters, ethylene glycol fatty acid esters, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, methyl glucoside fatty acid. Examples include lipophilic nonionic surfactants such as esters, alkyl glyceryl ethers, and trialkyl phosphates. On the other hand, specific examples of the hydrophilic nonionic surfactant include, for example, polyglycerin fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid ester. , Polyoxyethylene alkyl phenyl ethers, polyoxyethylene / polyoxypropylene ethers, polyoxyethylene / polyoxypropylene alkyl ethers, polyoxyethylene animal and vegetable oils, polyoxyethylene hardened animal oils, polyoxyethylene alkyl Amines, polyoxyethylene fatty acid amides, fatty acid alkanolamides, polyoxyethylene methyl glucoside fatty acid esters, sucrose fatty acid esters, alkylamine oxy It can be exemplified de and the like. Specific examples of the anionic surfactant include fatty acid soap, alkyl sulfate ester salts, alkyl ether sulfate ester salts, higher fatty acid amide sulfonate salts, alkyl phosphate ester salts, alkyl ether phosphate ester salts, and sulfosuccinic acid. Examples thereof include salts, alkyl sulfonates, alkyl ether carboxylates, acylamino acid salts, olefin sulfonates and the like. Furthermore, specific examples of the cationic surfactant include alkyltrimethylammonium salts, dialkyldimethylammonium salts, alkylbenzylammonium salts, alkylpyridinium salts, alkylbenzetonium salts, and the like. Furthermore, specific examples of amphoteric surfactants include imidazoline-based amphoteric surfactants, alkylbetaines, alkylaminoacetic acid betaines, sulfobetaines, amide betaines, and the like.

  Specific examples of animal and vegetable oils and fats include, for example, almond oil, avocado oil, apricot kernel oil, olive oil, killi oil, grape seed oil, beef tallow, beef bone marrow oil, wheat germ oil, rice bran oil, sasanqua oil, safflower oil, squalane, Camellia oil, lard, rapeseed oil, castor oil, castor oil, horse oil, palm oil, palm kernel oil, pristane, jojoba oil, macadamia nut oil, mink oil, cottonseed oil, coconut oil, rosehip oil, ozokerite, cocoa butter Etc. can be illustrated.

  Specific examples of fatty acid esters include isopropyl myristate, isopropyl palmitate, isostearyl isostearate, cetyl octanoate, butyl stearate, octyldodecyl myristate, butyl myristate, ethyl oleate, myristyl myristate, cetyl palmitate , Isocetyl myristate, Isocetyl stearate, Isostearyl palmitate, Isocetyl isostearate, Hexyl laurate, Cholesteryl stearate, Cetyl lactate, Diethyl sebacate, Diisopropyl sebacate, Diisopropyl adipate, Propylene glycol monocaprylate, Propylene dicaprylate Glycol, glyceryl trioctanoate, glyceryl tricaprylate, glyceryl tribehenate, triisostearate Phosphate trimethylolpropane trioctanoate pentaerythritol, can be exemplified monostearate batyl like.

  Specific examples of higher alcohols include, for example, lauryl alcohol, myristyl alcohol, cetyl alcohol, hexyl decanol, stearyl alcohol, oleyl alcohol, cetostearyl alcohol, batyl alcohol, ceralkyl alcohol, behenyl alcohol, octyldodecanol, cholesterol, phytosterol, jojoba alcohol, etc. Can be illustrated.

  Specific examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, 12-hydroxystearic acid, linoleic acid, linolenic acid, coconut oil fatty acid, castor oil fatty acid and the like. be able to.

  Specific examples of the polyhydric alcohol include ethylene glycol, propylene glycol, glycerin, butylene glycol, polyglycerins, trimethylolpropane, pentaerythritol and the like.

  Specific examples of the wax include, for example, paraffin wax, microcrystalline wax, carnauba wax, candelilla wax, whale wax, rice bran wax, ceresin wax, beeswax, owl, montan wax, hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated beef tallow and the like. be able to.

  Specific examples of the synthetic or natural polymer include, for example, polyvinyl alcohol, sodium polyacrylate, polyvinyl pyrrolidone, carboxyvinyl polymer, high molecular weight polyethylene glycol, methyl cellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, Examples thereof include crystalline cellulose, carboxymethyl starch, phosphorylated starch, gum arabic, alginic acid, albumin, casein, guar gum, carrageenan, agar, xanthan gum, collagen, dextran, starch, pectin, quince and the like.

  Specific examples of the preservative include methyl paraben, propyl paraben, isopropyl paraben, butyl paraben, phenoxyethanol and the like.

  Specific examples of pigments and dyes include, for example, titanium oxide, zinc oxide, iron oxide, anhydrous silicic acid, aluminum oxide, talc, kaolin, sericite, calcium carbonate, magnesium carbonate, calcium sulfate, magnesium sulfate, calcium silicate, Inorganic pigments such as magnesium silicate, aluminum silicate, hydroxyapatite, ultramarine, bitumen, carbon black, metal soaps such as aluminum stearate and calcium stearate, metal powders such as aluminum powder, titanium mica, bismuth oxychloride, Pearl pigments such as fish scale foil and pearl oyster powder, organic pigments such as azo pigments, indigo pigments, phthalocyanine pigments, red 201, red 202, red 203, red 204, red 205, red 206, Red 207, Red 208, Red 2 8, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 401, Red 504, Red 405, Red 506 , Orange color 201, orange color 205, orange color 206, orange color 207, orange color 401, yellow 201, yellow 203, yellow 204, yellow 401, blue 201, blue 204, Tar dyes such as green No. 202 and green No. 401, red No. 2, red No. 3, red No. 102, red No. 104, red No. 106, red No. 227, red No. 230, red No. 231, red No. 205, Dai No. 207, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Yellow No. 403, Yellow No. 407, Dai No Color 205, Dai No Color No. 207, Blue Lake pigments such as No. 1, Blue No. 2, Blue No. 404, Green No. 201, Green No. 204, Purple No. 401, Black No. 401, β-carotene, canthaxanthin, calsamine, rutin, cochineal, alizarin, chlorophyll, curcumin And natural pigments such as

Examples etc.

Next, the present invention will be described in more detail and specifically with reference to test examples and examples (formulation examples). The appearance of “S-100” in the special electrolytic reducing ion water used in the following test examples and examples is as follows.
Appearance: Colorless transparent liquid Odor: None pH (20 ° C.): 12.0-12.4
Specific gravity (20 ° C.): 1.002
Iron: 1 ppm or less Arsenic: 0.05 ppm or less Lead: 0.05 ppm or less Phenols: 0.005 ppm or less General viable count: 100 cells / ml or less Escherichia coli group: Not detected

Test Example 1 (S-100 stability over time)
Collect S-100 as a test solution in a 100 ml transparent glass bottle with a lid, and sample other companies' alkaline ionized water 1 and 2 as a control solution, and leave them at room temperature to change their pH and redox potential. And the appearance change was measured over time. In addition, HORIBA, pH / 10N meter, model F24 was used for pH measurement, and the appearance change was observed with the naked eye, and no significant difference was observed among the three, but pH change and oxidation-reduction potential change were As shown in Table 1 below, it was found that S-100 was clearly milder than other products and superior in stability.

Test example 2 (antibacterial action of S-100)
As a test method, a generally used “plate culture method” was used, and the storage temperature was set to 25 ° C. As a control, sterilized purified water was used, and the number of viable bacteria in the control was measured at the start of the test to obtain a value at the start. The results are as shown in Table 2 below, and it was confirmed that S-100, which is the test water, was significantly superior in antibacterial activity when compared to any of the bacteria. It was.

Test Example 3 (Acute toxicity test)
As an acute toxicity test for S-100, a fish toxicity test was carried out against Himedaka. The test conditions are as follows.
Test fish: Himedaka (average length 3.0 cm, average weight 0.24 g)
Acclimatization conditions: For 14 days before the test, the animals were acclimated under the same water quality (diluted water), temperature and lighting conditions as the test conditions. The mortality rate of the test fish during the acclimatization period was 5% or less. Number of fish per group: 10 fish Water temperature: 23 ± 1 ° C
Lighting: 14 hours / day Test vessel: Round glass water tank Diluted water: Tap water (pH 7.9) from which residual chlorine has been removed by natural standing
Preparation of test water: Each concentration of test water was prepared by adding S-100 to dilution water. The control group was diluted water only.
Measurement: The behavior of the test fish in each test section was observed, and the number of deaths after 24, 48, 72 and 96 hours was recorded.

  The S-100 concentration of the test water was set to 1000-100000 ppm, but there were no deaths in the test group and the control group. Therefore, the 0% mortality rate is 100000 mg / l or more, and it is 218.341 g / g or more per body weight. Therefore, it was proved that S-100 exhibits substantially no toxicity.

Test example 4 (detergency test)
With S-100 as the test water, the alkaline ionized water of the other company used in Test Example 1 as the control waters 1 and 2, and a commercially available kitchen detergent mainly composed of a surfactant as a standard product, these detergency Were evaluated in accordance with the detergency evaluation method of 7.2 (kitchen detergent for detergent) of JIS K3362 (synthetic detergent test method).

  Wash for 3 minutes using a detergency tester (rotation speed 250 ± 10 rpm) equipped with a piece of glass with standard soil (a mixture of beef tallow, soybean oil, monoolein and oil red) and then rinse for 1 minute Then air dried at room temperature for one day. Evaluation was performed by immersing a glass piece in a chloroform solution and visually comparing the degree of redness (degree of soiling) of the chloroform solution with a standard product. The results are as shown in Table 3 below, and it was found that S-100 has a detergency that is almost the same as the standard solution.

Test Example 5 (Antistatic effect)
In accordance with the washing method number 103 defined in JIS L0217, a sample water (100% polyester) subjected to washing-rinsing-dehydration-air drying was added to sample water (S-100 as test water, Test Example 1 as control water). Sprayed with 20 ml / m 2 of alkaline ionized water 1 and 2 of other companies and commercial pure water used in 1) and dried with hot air (70 ° C.) for 1 hour. The sample was then conditioned for 24 hours (temperature 20 ± 5 ° C., relative humidity 40% or less) and enclosed in a polyethylene bag. The sample was placed in a rotary friction device and run on a drum at 60 ± 10 ° C. for 15 minutes. A sample was taken out of the drum with an insulating glove, put into a Faraday gauge of a charged charge measuring device, and a numerical value V (v) of a potentiometer was read to obtain a charged charge amount Q (C). The static electricity charged on the sample was removed by using a self-discharge type static eliminator every time. The results are as shown in Table 4 below, and S-100 was found to be excellent in the antistatic effect.

Test Example 6 (Deodorizing Effect ) 1 g of sample water (S-100 as test water and alkali ion waters 1 and 2 of other companies used in Test Example 1 as control water) was weighed into a container and sealed. 50 μl of methyl mercaptan was poured into a tightly sealed container using a gas tight syringe and left at room temperature with shaking. Over time, the gas in the container was injected into the gas chromatogram. A blank test was performed in the same manner, the peak height on the obtained gas chromatogram was measured, and the residual rate at each measurement time of the sample was measured using the blank as 100. The results are as shown in Table 5 below, and S-100 was found to be extremely excellent in the deodorizing effect.

Example 1 (lotion)
Treatment weight%
S-100 77.0
1,3-butylene glycol 10.0
Polyoxyethylene (10) sunflower oil 2.0
(Product name: FLORASUN PEG-10, FLORATECH)
Polyoxyethylene (20) oleyl ether 1.0
Ethanol 10.0
Perfume

Preparation method:
Ingredients other than ethanol and S-100 are mixed and heated with stirring to make uniform. Ethanol is added to the mixture and mixed well, and then S-100 is further added and mixed to obtain a uniform solution.

Example 2 (beauty gel for preventing wrinkles)
Treatment weight%
GE-100 82.0
1,3-butylene glycol 10.0
Hydroxyethyl cellulose 1.0
Soy protein hydrolyzate 3.0
(Product name: PHYLDERM VEGETAL C, GATTEFOSSE)
Beech bud extract 5.0
(Product name: GATULINE RC, GATTEFOSSE)

Preparation method:
Hydroxyethyl cellulose is dispersed in water and left standing. The other ingredients are then added with gentle stirring.

Example 3 (makeup remover)
Treatment weight%
GE-100 88.0
POE (10) sunflower oil 2.0
(Product name: FLORASUN PEG-10, FLORATECH)
Propylene glycol 10.0
Preparation method:
Add all ingredients and stir and mix until uniform.

Example 4 (nutrition cream)
Treatment weight%
POE (8) Beeswah 8.0
(Product name: APIFIL, GATTEFOSSE)
Octyldodecyl myristate 10.0
Isostearyl isostearate 10.0
S-100 64.4
Carboxyvinyl polymer 0.2
(Product name: Carbopol 934, BF Goodrich)
Sodium hydroxide (10% aqueous solution) 0.4
Beech bud extract 2.0
(Product name: GATULINE RC, GATTEFOSSE)
Diethylene glycol monoethyl ether 5.0

Preparation method:
Carbopol is dispersed in water. While stirring, an aqueous carbopol solution heated to 75 ° C. is added to the mixture of APIFIL and ester heated to 75 ° C. Next, an aqueous sodium hydroxide solution is added to adjust the pH to about 7. Cool with stirring and add other ingredients at 30 ° C. to cool completely.

Example 5 (milky lotion for moisturizing)
Treatment weight%
POE (6) stearate and POE (20) cetyl acetate 6.0
Mixture of Pt and POE (20) stearyl ether
(Product name: TEFOSE 2000, GATTEFOSSE)
Stearic acid 1.0
Glyceryl stearate 1.0
Isostearyl isostearate 6.0
Sunflower oil 4.0
(Product name: FLORASUN 90, FLORATECH)
Dimethylpolysiloxane (100CS) 2.0
S-100 76.8
Hydroxyethyl cellulose 0.2
Collagen 3.0
(Product name: PANCOGENE MARIN, GATTEFOSSE)

Preparation method:
Hydroxyethyl cellulose is dispersed in water and allowed to stand. While stirring, an aqueous hydroxyethyl cellulose solution heated to 75 ° C. is added to the emulsifier and oil phase heated to 75 ° C. Hold at 75 ° C. for 2-3 minutes, cool with stirring, add other ingredients at 30 ° C. and cool completely.

Example 6 (Liquid Foundation)
Treatment weight%
(A)
S-100 60.2
Carboxymethylcellulose 0.3
Magnesium aluminum silicate 0.8
1,3-butylene glycol 10.0
(B)
Talc 3.0
Titanium oxide 5.0
Bengala 0.5
Yellow iron oxide 1.5
Black iron oxide 0.1
(C)
Jojoba ester 5.0
(Product name: FLORAESTERS 30, FLORATECH)
Isopropyl palmitate 7.0
Tocopherol acetate 0.2
Cetanol 0.5
Stearic acid 2.5
Decaglycerin monooleate 1.2
Decaoleic acid decaglycerin 2.0
(D)
Triethanolamine 0.4

Preparation method:
Heat the A-100 S-100 to 75 ° C. CMC and magnesium aluminum silicate are mixed in advance and added to the heated S-100 with rapid stirring. The remaining components of the phase A are mixed in advance, added to the S-100 solution containing CMC and magnesium aluminum silicate with gentle stirring, and mixed at 75 ° C. for 20 minutes. While stirring with a high-speed homomixer, add the phase B component to phase A at 75 ° C. and stir for 30 minutes. The C phase component is heated to 80 ° C. with stirring and gradually added to the A + B phase at 80 ° C. with gentle stirring. After stirring for 20 minutes, cool to 75 ° C. with stirring, then add Phase D ingredients to adjust pH to about 7 and cool to room temperature.

Example 7 (W / O type foundation)
Treatment weight%
(A)
Triglycerin diisostearate 2.0
Hardened castor oil 1.0
Liquid paraffin 14.0
Dimethylpolysiloxane 2.0
(B)
Lipophilic treated titanium oxide 6.4
Yellow iron oxide 1.0
Bengala 1.0
Triglyceryl diisostearate 3.0
Liquid paraffin (C)
S-100 68.6
Sodium carbonate 0.5
Magnesium sulfate 0.5

Preparation method:
Using three rolls, the B phase component is kneaded to make it uniform (number of kneading: 3 times). Add Phase B ingredients to Phase A. While stirring rapidly, add Phase C component heated to 85 ° C. to Phase (A + B) heated to 85 ° C. and cool with stirring.

Example 8 (deodorant antiperspirant)
Treatment weight %
GE-100 54.0
Ethanol 30.0
Aluminum chlorohydrate 5.0
1,3-butylene glycol 10.0
Benzalkonium chloride solution 1.0
Perfume

Preparation method:
Ingredients other than ethanol and flavor are mixed and made uniform. Subsequently, a fragrance | flavor and ethanol are added and mixed.

Example 9 (Whitening serum)
Treatment weight%
GE-100 81.8
1,3-butylene glycol 5.0
L-ascorbyl magnesium phosphate 3.0
Sodium metasulfite 0.2

Preparation method:
Mix all ingredients and homogenize with stirring.

Example 10 (gel ointment)
Treatment weight%
GE-100 81.0
Hydroxyethyl cellulose 1.0
Indomethacin 3.0
Propylene glycol 5.0
Diethylene glycol monoethyl ether 10.0

Preparation method:
After hydroxyethylcellulose is dissolved in GE-100, the remaining components are added and mixed until uniform.

Example 11 (Liquid detergent for kitchen)
Treatment weight%
S-100 87.5
Alkyl ether sulfate 5.0
Palm oil fatty acid diethanolamide 2.0
EDTA-2Na 0.5
Propylene glycol 5.0
Perfume

Preparation method:
Mix all ingredients and stir until uniform.

Example 12 (Bactericidal detergent for bathroom)
Treatment weight%
S-100 94.0
Benzalkonium chloride solution 1.0
Polyoxyethylene alkyl ether 2.0
(Product name: Softanol 90, Nippon Shokubai)
Sodium metasilicate 3.0

Preparation method:
Mix all ingredients and stir until uniform.

Example 13 (soap-type body cleaning agent)
Treatment weight%
Lauric acid 3.0
Myristic acid 7.0
Palmitic acid 2.0
Oleic acid 3.0
Lauroyl diethanolamide 5.0
Glycerin 20.0
Potassium hydroxide 3.5
S-100 56.5
Perfume appropriate amount Chelating agent appropriate amount

Preparation method:
Components other than potassium hydroxide and S-100 are mixed and stirred while heating, and then an aqueous solution of potassium hydroxide is added. Stir and cool until uniform.

Example 14 (Liquid Body Soap)
Treatment weight%
Sodium polyoxyethylene lauryl ether sulfate 30.0
Ammonium lauryl ether sulfate 15.0
Palm fatty acid diethanolamide 4.0
Sodium chloride 2.0
Plant extract 3.0
Chelating agent appropriate amount S-100 46.0

Preparation method:
Ingredients other than plant extract are mixed and mixed while heating to make uniform. Next, the mixture is cooled with stirring, and when the temperature reaches room temperature, the plant extract is added and mixed.

Example 15 (Liquid bath agent)
Treatment weight%
Polyoxyethylene (30) Polyoxypropylene (6) 20.0
Decyl tetradecyl ether Glycerin 25.0
Sunflower oil 25.0
Perfume appropriate amount S-100 30.0

Preparation method:
Components other than S-100 are mixed and made uniform while stirring. While stirring this mixture, S-100 is added and mixed.

Example 16 (gel fragrance)
Treatment weight%
GE-100 74.5
Carbopol 940 0.5
Fragrance 5.0
Dye appropriate amount Ethanol 20.0
Triethanolamine appropriate amount

Preparation method:
The carbopol is dispersed in GE-100 and allowed to stand. To this, ingredients other than triethanolamine are added and stirred to make uniform. Triethanolamine is then added to adjust the pH to about 7.

Effect of the invention

【Effect of the invention】
The pharmaceutical composition according to the present invention is S-100, which is a special electroreductive ionic water obtained by electrolyzing natural water and energizing / pressurizing using a special diaphragm device and physically having excess electrons. And / or GE-100. These S-100 and GE-100 are highly functional waters having a long-lasting sterilization and antifungal action, oil emulsifying action, deodorizing action, antistatic action and the like, and are extremely excellent as water for preparing a pharmaceutical composition. For example, if an emulsifying action is used, the necessity of using a surfactant is eliminated. In particular, GE-100 is normally in the form of a gel, and when subjected to vibration, the viscosity decreases and becomes liquid, and has the property of returning to the gel normal state when left standing, and if GE-100 is used, The gel-form preparation can be prepared without using a special gelling agent.

Claims (4)

S-100 (trade name: Multi-cleaner S-100) obtained by electrolyzing natural water 77.0% by weight, 1,3-butylene glycol 10.0% by weight, polyoxyethylene (10) sunflower oil A lotion comprising 2.0% by weight, 1.0% by weight of polyoxyethylene (20) oleyl ether, and 10.0% by weight of ethanol .
GE-100 (trade name: Multi-cleaner GE-100) 82.0% by weight obtained by electrolyzing natural water, 10.0% by weight of 1,3-butylene glycol, 1.0% by weight of hydroxyethyl cellulose, A cosmetic gel for preventing wrinkles, comprising 3.0% by weight of soybean protein hydrolyzate and 5.0% by weight of beech bud extract .
POE (8) beeswax 8.0 wt%, octyldodecyl myristate 10.0 wt%, isostearyl isostearate 10.0 wt%, S-100 obtained by electrolyzing natural water (trade name: Multi-cleaner S-100) 64.4 wt%, carboxyvinyl polymer 0.2 wt%, sodium hydroxide (10% aqueous solution) 0.4 wt%, beech bud extract 5.0 wt%, diethylene glycol monoethyl ether 5. A nutritional cream characterized by containing 0% by weight .
GE-100 (trade name: Multicleaner GE-100) obtained by electrolyzing natural water 81.0% by weight, hydroxyethylcellulose 1.0% by weight, indomethacin 3.0% by weight, propylene glycol 5.0% by weight %, A gel-like ointment containing 10.0% by weight of diethylene glycol monoethyl ether .