JPH0920667A - Production of calcium ion-containing water and skin cleaning/cleaning material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To easily obtain the calcium ion-containing water capable of preventing the secondary infection in the inflammation of atopic dermatitis, effective for suppressing pruritus and burning sensation involved in the inflammation, thus useful as a skin cleansing/cleaning material, by mutual contact between chilled purified water and Ostreae testa powder. SOLUTION: (A) Chilled purified water is brought into contact with (B) Ostreae testa powder to effect leaching calcium ions. In this case, the component A pref. contain (C) a leaching and stabilizing auxiliary for the calcium ions (e.g. glycerol). Specifically, for example, the objective calcium ion-contg. water is pref. obtained by the following process: the component B containing about 60wt.% of calcium as the chief ingredient (e.g. obtained by current injection treatment of the pearl layer of oystershells) is brought into contact with the component A at about 0-10 deg.C to effect leaching calcium ions so as to be about 800-1,000ppm in concentration of the calcium ions.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a method for producing calcium ion water and a material for cleaning and wiping skin using the same, and more specifically, to elute calcium ions from bole powder using cold purified water to prevent bacteria.・ Method for producing calcium ion water having antifungal effect, and skin cleaning / cleaning material in which the base cloth is impregnated with the calcium ion water, and atopy made of these calcium ion water or skin cleaning / cleaning material The present invention relates to a composition for preventing secondary infection during inflammation of dermatitis and suppressing itching and hot flashes associated with inflammation.

[0002]

2. Description of the Related Art Conventionally, synthetic cotton and cleaning cloths for the purpose of cleaning and cleaning the skin are synthetic sterilizers such as cetylpyridinium chloride, benzalkonium chloride, alkyltrimethylammonium chloride, chlorhexidine gluconate solution, and triclosan. Agents, benzoic acid, preservatives such as paraoxybenzoic acid alkyl esters are mixed. However, the cleaning / cleaning materials containing these bactericidal / preservatives have no problem in application to healthy skin, but may cause skin troubles in the treatment of allergic skin and inflamed skin. Not suitable. Therefore, it is obligatory to label the products containing these sterilizing / preservatives as a designated component.

[0003]

DISCLOSURE OF THE INVENTION The object of the present invention is to sterilize the conventional sterilizers which are concerned about the safety of the skin as described above.
Establish a method for producing calcium ion water, which is expected to be applied to people with weak skin, in place of preservatives, and establish a method for producing more stable calcium ion water. Providing a safe skin cleansing and wiping agent that utilizes properties and preventing secondary infection during inflammation of atopic dermatitis consisting of these calcium ion water or skin cleansing and wiping materials. The purpose of the present invention is to provide a composition for suppressing itching and hot flashes associated with inflammation.

[0004]

Means for Solving the Problems As a result of extensive studies for solving the above problems, the present invention uses boley powder as a calcium source, and how
Maintaining a stable state over time by eluting calcium ions at an effective concentration that produces a mildew-proofing effect to produce calcium ion water, or impregnating absorbent cloth, non-woven fabric, gauze, or other base cloth with calcium ion water A method to prepare calcium ion water by solving the problems such as whether it can be used as a cleansing and wiping agent for skin, stirring and shaking from cold powdered water to extract calcium ions, and elution from boley powder・ We found a method to prepare more effective and stable calcium ion water by stirring and shaking with cold purified water with auxiliary agent added, and further using these calcium ion water as the active ingredient in the base fabric. The present invention has been completed by finding that an impregnated skin cleaning / cleaning material is useful.

That is, the invention of claim 1 of the present invention is a method for producing calcium ion water, characterized in that cold purified water and boley powder are contacted to elute calcium ions.

The invention of claim 2 of the present invention is characterized in that cold purified water containing a calcium ion elution / stabilization aid is brought into contact with boley powder to elute and stabilize calcium ions. Is a manufacturing method.

The invention of claim 3 of the present invention is a cleansing and wiping material for skin, characterized in that the base cloth is impregnated with the calcium ion water according to claim 1 or 2 as an active ingredient.

The invention according to claim 4 of the present invention is characterized in that the material for cleaning and wiping skin according to claim 3 is housed in a packaging container having a take-out port which can be taken out one by one when used. .

The invention according to claim 5 of the present invention comprises the calcium ion water according to claim 1 or 2 or the skin cleaning / cleaning material according to claim 3 or 4. It is a composition for preventing secondary infection during inflammation of atopic dermatitis, and for suppressing itching and hot flashes associated with inflammation. Hereinafter, the present invention will be described in detail.

The boley powder used in the present invention is oyster family (Os
oysters (Treaidae)
The white part of the shell of humberg) is crushed, washed and sized. Specific examples of boley powder preferably used in the present invention include, for example, those containing approximately 60% by weight of calcium as a main component obtained by subjecting a pearl layer of an oyster shell to an electric current treatment (trade name: Kaihou Hysea S. , Manufactured by Kaihou Co., Ltd.).

The calcium ion water according to the present invention and the calcium ion water which is stable with time are, for example, cold purified water (deionized water) added to boley powder, and the mixture is stirred and shaken and left for one day and night. A method of collecting and obtaining calcium ion water, and adding cold purified water with an elution / stabilization aid to boley powder, stirring and shaking, and leaving it for one day and night, collecting the supernatant liquid and stabilizing calcium over time. It can be obtained by a method of obtaining ionized water. The temperature of the cold purified water is, for example, about 0 to 10 ° C, preferably about 0 to 5 ° C, and particularly preferably about 4 ° C. If the temperature is lower than 0 ° C, elution of calcium ions is delayed, which is not preferable. If it exceeds 10 ° C, the temperature further rises due to the exothermic reaction during dissolution, and the solubility of calcium ions decreases. The calcium ion water thus prepared has antibacterial properties and can be used as an active ingredient in a skin cleansing and wiping material.

The raw materials used in the above-mentioned calcium ion water preparation operation include "Borei powder" (preferably food additives) listed in "Japanese Pharmacopoeia", "Food Additive Official Document" and "Cosmetic Raw Material Nonstandard Component Standards". The above-mentioned "Kaihou Hyceer S: manufactured by Kaihou Co., Ltd.") is used as a product, and as a dissolution / stabilization aid, polyhydric alcohols such as glycerin, sorbitol, propylene glycol, 1,3-butylene glycol, and ethanol. ,
Alcohols such as isopropanol can be used.

In addition, thickeners such as carrageenan, xanthan gum, polyvinyl alcohol, carboxyvinyl polymer and the like listed in "Japanese Pharmacopoeia", "Food Additives Officially Registered Document" and "Cosmetic Raw Material Nonstandard Standards", dl-pyrrolidone carboxylic acid Sodium acid solution, sodium hyaluronate solution, moisturizer such as macrogol, arnica extract, aloe extract, seaweed extract, chamomile extract, licorice extract, peach leaf extract, hypericum extract, rosemary extract, quina extract, garlic extract, melissa extract, etc. The plant extract can be appropriately added to the above-mentioned calcium ion water as long as the intended effect of the present invention is not impaired.

The dosage form of the above-mentioned calcium ion water may be any of those which can be applied to the outer skin such as lotion, milky lotion and gel. The calcium ion water may be impregnated into a base cloth such as absorbent cotton, non-woven fabric or gauze. The anti-bacterial / mildew-proof clean cotton, wet tissue, gauze, etc. of the present invention can be used as the skin cleansing / cleaning material of the present invention.

Examples of the base fabric impregnated with calcium ion water include all non-woven fabrics made of absorbent cotton, gauze, cellulose or rayon of the Japanese Pharmacopoeia (JP).

[0016]

Calcium ion water for use DETAILED DESCRIPTION OF THE INVENTION The present invention is contacted with a temperature of about 0 ° C. cold purified water Borei powder containing approximately 60 wt% of calcium as a main component of calcium ions (Ca ^{+ +} ) Is eluted and about 500 to 1500 p of the whole is obtained as calcium ions (Ca ⁺⁺ ).
Calcium ionized water having a concentration of pm, preferably about 800 to 1000 ppm.

As an elution / stabilization aid for elution and stabilization of calcium ions (Ca ⁺⁺ ) by contacting bovine powder with cold purified water, many glycerin, propylene glycol, 1,3-butylene glycol and the like are used. Approximately 2 to 1 of the total amount of the polyhydric alcohols individually or in combination.
0% by weight, preferably about 3 to 5% by weight.

As the base fabric used in the present invention, all non-woven fabrics made of natural cellulose or rayon, absorbent cotton, gauze and the like cut into an appropriate size can be used. Can be impregnated with it to provide the skin cleansing and wiping material of the present invention. The impregnated amount of calcium ion water is about 2 to 4 ml, preferably about 2.5 to 3.5 ml per 1 g of the base cloth in the case of the non-woven fabric or gauze, and about 4 to 6 ml per 1 g of the base cloth in the absorbent cotton. Preferably about 4.5-
The standard is to impregnate 5.5 ml. However, the amount of calcium ion water to be impregnated into the non-woven fabric, absorbent cotton, gauze, etc. varies depending on the weight and thickness of the base fabric, the composition of calcium ion water, the dosage form, etc., and is not particularly limited. It is preferred that the saturated impregnated amount of calcium ion water with respect to the base fabric be within a range so that the impregnated amount can achieve the object of the present invention without dropping during use.

The packaging container for enclosing the skin cleaning / wiping material of the present invention is not particularly limited. Specific examples of preferred packaging containers that can achieve the object of the present invention include a base cloth impregnated with a composition of a certain amount of calcium ion water or calcium ion water containing an elution / stabilizing auxiliary agent, etc. Examples include synthetic resin containers such as cylinder type, prismatic type, lunch box type, bag type, etc. that have a sealable outlet that can be taken out, and pouch type containers made of synthetic resin or enclosed in an aluminum laminate film. it can.

[0020]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. In the following description and examples,% means% by weight unless otherwise specified.

Examples for preparing calcium ion water constituting the present invention, characteristics of calcium ion water such as ion concentration, stability over time, antibacterial and antifungal properties will be described. (Example 1) Boiling powder (trade name: Kaihou Hysea S) (1 g) was preliminarily boiled to drive out dissolved carbonic acid, 100 ml of purified water cooled to 5 ° C or lower was added, and the mixture was shaken with stirring and allowed to stand still in a refrigerator for one day and night. After that, the supernatant was collected to obtain about 75 ml of calcium ion water.

(Examples 2 to 5) Dissolved carbonic acid previously boiled in 1 g of the same boreal powder was rid of, and then glycerin (Example 2) was added as a stabilizing aid in purified water cooled to 5 ° C or below.
Or propylene glycol (Example 3), or 1,
Solution 10 containing 3 g of 3-butylene glycol (Example 4) or 3 ml of absolute ethanol (Example 5) 10
After adding 0 ml and stirring and shaking, the mixture was allowed to stand in the refrigerator for one day and night, and the supernatant was recovered to obtain about 75 ml of calcium ion water.

When the recovery rate, properties, calcium ion concentration and the like of Example 1 and Examples 2 to 5 were confirmed, the following results were obtained. (Recovery rate): The yield of calcium ion water is
It was about 75% in each of Examples 2 to 5. (Property): A colorless and clear liquid with a slightly peculiar odor. (Calcium ion concentration): Example 1 and Examples 2-5
The calcium ion (Ca ⁺⁺ ) concentration of the calcium ion water obtained in 1. was measured by an ion electrode method (mV) using a digital pH / mV meter manufactured by Fischer Akiyumet.
Measurement) and a chelate titration method using a disodium edetate solution. Table 1 shows the results.

[0024]

[Table 1]

As shown in Table 1, Example 1 and Example 2
Calcium ion (Ca ⁺⁺ ) concentrations in -5 were highest when glycerin was added as an elution / stabilization aid (Example 2), and propylene glycol (Example 3) was particularly effective. .

When the stability of calcium ionized water in Examples 1 and 2 to 5 was confirmed, the following results were obtained. The calcium ion water prepared according to Example 1 is not problematic if it is stored in a container sealed in a container with air blocked, but when stored in an open state at room temperature for a long time (3 months or more), calcium hydroxide (Ca (Ca ( Part of OH) ₂ ) forms calcium carbonate (CaCO ₃ ) due to carbon dioxide in the air, which may cause turbidity. On the other hand, Example 2
The calcium ion water prepared by ~ 5 does not become turbid even when stored for a long time (more than 1 year) in the released state, and glycols added as an elution / stabilization aid function as a stabilizer. It was confirmed.

(Examples 6 to 9) The calcium ion water prepared in Examples 1 and 2 was applied to a nonwoven fabric (Example 6), absorbent cotton (Examples 7 and 8) and gauze (Example 9). The skin cleansing and wiping material of the present invention was produced by impregnation under the conditions shown in 2, and the following experiments were conducted for the purpose of confirming their antibacterial effect. That is, a sample was prepared by impregnating the non-woven fabric (trade name: Benlyse, manufactured by Asahi Kasei Co., Ltd.), absorbent cotton (JP) and gauze (JP) with the calcium ion water obtained in Examples 1 and 2. On the other hand, the effect was compared with a control product in which the non-woven fabric (Comparative Example 1), the absorbent cotton (Comparative Example 2) and the gauze (Comparative Example 3) were impregnated with sterilized physiological saline under the conditions shown in Table 3. . Regarding the gauze in the base cloth, a sample that was washed with hot purified water and then dried again was used. In both cases, the base cloth was impregnated aseptically after steam-heat sterilizing the base cloth at 121 ° C. for 15 minutes.

[0028]

[Table 2]

[0029]

[Table 3]

(Measurement of antibacterial activity): Example 1 and Example 2
Samples 1 to 4 (Examples 6 to 9) for cleaning and cleaning the skin of the present invention prepared by impregnating the calcium ion water obtained in 1. and control samples 5 to 7 prepared by impregnating sterilized physiological saline.
Regarding (Comparative Examples 1 to 3), the antibacterial activity was measured according to the method for measuring the number of bacteria in "Testing method for evaluating processing effect of sanitary products" of the Textile Products Sanitary Processing Association. That is, Staphylococcus aureus 20
The bacterial suspension of 9P), and 0.2ml increments inoculated into each sample, was measured number of bacteria and incubated for 18 hours immediately after Nyukin, increase or decrease value difference of the common logarithm value _{(log 10) (log ≧ 1} . 6: Effective) was obtained and evaluated. Table 4 shows the results.

[0031]

[Table 4]

As shown in Table 4, the non-woven fabric was impregnated with the sample 1 obtained in Example 1 by impregnating the nonwoven fabric with the calcium ion water, the sample 2 impregnated with absorbent cotton, and the calcium ion water obtained in Example 2 was absorbed by the absorbent cotton. The impregnated sample 3 and the sample 4 impregnated with gauze showed excellent antibacterial activity against Staphylococcus aureus. Staphylococcus aureus is a typical type of pathogen that is resident in the epidermis and is a causative bacterium of secondary infection during inflammation such as atopic dermatitis, and the skin cleaning / cleaning material of the present invention is atopic. This proves that it is useful for preventing secondary infection during inflammation such as dermatitis.

(Confirmation of antifungal property): The result of measuring the minimum inhibitory concentration (MIC) of calcium ion water prepared from boley powder (trade name: Kaihou Highsea S) against certain yeasts and molds Is shown in Table 5.

[0034]

[Table 5]

From the above experimental results, the composition of the present invention (calcium ion water used in the present invention and the skin cleansing / cleaning material of the present invention) was found to contain the above-mentioned calcium ion water, elution / stabilizing auxiliary agent, base cloth, etc. It has been found that it is preferable to consist of the following components.

A specific embodiment will be additionally described below. Example 10 A lotion (composition) was produced by mixing and dissolving according to the following formulation. Aloe extract 2.0 g Chamomile extract 0.5 g Licorice extract 0.5 g Peach leaf extract 0.5 g Arnica extract 0.1 g Glycerin 2.0 g Calcium ion water prepared by the method of Example 2 was added to make a total volume of 100.0 ml. . The obtained lotion was applied to a non-woven fabric (size: 140 × 200 mm) per 1 g of weight,
When the skin was wiped using a wet tissue impregnated with 3.0 ml, the effect of suppressing "itch" and "hot flash" associated with skin inflammation was observed.

Example 11 A lotion (composition) was produced by mixing and dissolving according to the following formulation. dl-Pyrrolidonecarboxylate sodium solution 1.0 g Seaweed extract 0.5 g Chamomile extract 3.0 g Arnica extract 0.1 g Propylene glycol 5.0 g Calcium ion water prepared by the method of Example 1 was added to make a total amount of 100.0 ml. . The obtained lotion was added to absorbent cotton (size: 75 × 80 mm) per 1 g of weight, and
When cleaning the skin with 0 ml of impregnated cleansing cotton,
The effect of removing dirt and unpleasant odor of the skin, giving a refreshing scent and a moist feeling was recognized.

Example 12 A gel lotion (composition) was produced by mixing and dissolving it according to the following formulation. Sodium hyaluronate solution Sodium acid solution 2.0 g Carrageenan 0.5 g Arnica extract 0.1 g Sodium paraoxybenzoate 0.2 g 1,3-butylene glycol 3.0 g Calcium ionized water prepared by the method of Example 2 was added. The total volume was 100.0 ml. The gel-like lotion obtained was applied to a nonwoven fabric (size: 140 x 200 mm) and weighed 1 g.
To remove the unpleasant odor of the skin when wiping the skin with a wet tissue impregnated with 3.5 ml,
A refreshing fragrance and a moisturizing effect were recognized.

Example 13 A gel-like lotion (composition) was produced by mixing and dissolving according to the following formulation. Macrogol 400 4.0 g Hydroxypropyl cellulose 1.0 g The calcium ion water prepared by the method of Example 2 was added to make the total amount 100.0 ml. 1 g of the obtained gel lotion was added to gauze (size: 200 x 200 mm).
When a gauze pad impregnated with 4.0 ml was applied to the inflamed area (affected area) of the epidermis due to a burn, the effect of suppressing "hot flashes" in the affected area and promoting recovery of damage was recognized.

[0040]

As described above, by using cold purified water, it is possible to easily produce calcium ion water by eluting calcium ions having antibacterial and antifungal effects from boll powder. By using cold purified water containing a calcium ion elution / stabilizer, stable calcium ion water that does not become turbid even when stored for a long period in an open state can be easily produced.

The skin cleansing and wiping material of the present invention is one in which the base cloth is impregnated with these calcium ion water (natural composition) having antibacterial and antifungal effects, and it is safe.
It is easy to use.

If the skin cleansing and wiping material of the present invention is stored in a packaging container having a take-out port which can be taken out one by one at the time of use, it is easy and convenient to use.

The calcium ionized water and the skin cleansing and wiping material of the present invention are yellow resident in the epidermis which is a causative bacterium of secondary infection which is a problem in inflammation such as atopic dermatitis. Because of its excellent antibacterial activity against staphylococcal bacteria, it is possible to manufacture a product which is useful especially for use in atopic dermatitis to prevent secondary infection. In addition, the skin cleansing and wiping material of the present invention is used in combination with the plant extracts specifically mentioned in the examples, particularly when used for atopic dermatitis, to prevent secondary infection and to accompany inflammation. It is possible to provide a useful product that is useful for soothing "itchiness" and "hot flashes".

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Hiroshi Suhara 846-3 Tokaichiba, Midori-ku, Yokohama-shi, Kanagawa

Claims (5)

[Claims] 1. A method for producing calcium ionized water, which comprises bringing cold purified water into contact with boley powder to elute calcium ions. 2. A method for producing calcium ion water, which comprises contacting cold purified water containing a calcium ion elution / stabilization aid with boley powder to elute and stabilize calcium ions. 3. A cleansing / cleaning material for skin, wherein a base cloth is impregnated with the calcium ion water according to claim 1 or 2 as an active ingredient. 4. The skin cleaning / cleaning material according to claim 3, which is contained in a packaging container having a take-out port which can be taken out one by one at the time of use. 5. At the time of inflammation of atopic dermatitis, which comprises the calcium ionized water according to claim 1 or 2, or the skin cleansing / cleaning material according to claim 3 or 4. For preventing secondary infection in the above and suppressing itch and hot flash associated with inflammation.