CN109512859A - Rabdosia rubescens lyophiled powder preparing technique - Google Patents
Rabdosia rubescens lyophiled powder preparing technique Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The invention discloses Rabdosia rubescens lyophiled powder preparing techniques, it is raw material by using Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud, the mode processed respectively, by different control technique come so that Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud dried frozen aquatic products respectively reach it is best in quality, then the mode prepared again produces the high Rabdosia rubescens dried frozen aquatic products of quality, convenient for promoting the use of Rabdosia rubescens as health care product.
Description
Technical field
The present invention relates to Chinese medicine preparation fields, and in particular to Rabdosia rubescens lyophiled powder preparing technique.
Background technique
Rabdosia rubescens also known as rabdosia rubesens are Labiatae scented tea category perennial herb or undershrub, and undershrub is Labiatae scented tea
Lepidium plant is cracked rice fork mutation, is gained the name because its plant condenses butterfly-shaped ice slush piece that is as thin as cicada's wings, coming in every shape.Complete stool knot Man Yin
White borneol.There is the benefits of anti-inflammatory analgetic, stomach invigorating promoting blood circulation.
Rabdosia rubescens belongs to positive shade plant, slightly happiness yin；Winter resistance is strong, has not only been resistant to -20 DEG C of low temperature, but also is resistant to 50 DEG C of height
Temperature, preference temperature are 25~30 DEG C, and 10~40 DEG C are suitble to growth.Temperature stops growing substantially lower than 5 DEG C.Sprout tiller strength is strong, resistance to dry
Non-irrigated, barren, even if summer soil moisture content is lower than 4%, Rabdosia rubescens still is able to grow, adaptable, requires soil not tight；Soil
Layer depth thickness, fertile soil, sand loam, pH6.5~8.0, Rabdosia rubescens growth are best.8~October of florescence, full-bloom stage September are bloomed
Preference temperature is 18~26 DEG C, and relative humidity is 60%~80%.Its every winter natural temperature is at 0 degree or less, it complete
Full silvery white borneol is tied in strain, windproof, is flickered with the wind, glittering after sunrise, shows magical natural landscape, is had only
The ornamental effect arrived, if making plate plantation with aithullium and winter flowers, it is very complete that motley visual effect, which is worked as,
The features such as U.S. picture scroll Rabdosia rubescens source area weather is more severe, cold-resistant, drought-resistant, pest and disease damage is few, management is easy, it can afforested
Deserted mountain checks winds and fixes drifting sand, has good utility value in water and soil conservation.Its florescence is long simultaneously, flower amount is big, is that good nectar source is planted
Object.
Rabdosia rubescens is a kind of plant with comprehensive development and utilization value.Rabdosia rubescens is adaptable, not tight to soil requirement,
Select in drying, be not easy ponding sand or light clay soil plantation.Implantation time is advisable in spring and autumn, and 4000 plants of mu kind or so.Winter
Insulting the main management of grass is tillage and weeding, anti-ponding.NATURAL DISTRIBUTION leads to resource exhaustion due to unauthorized and excessive mining in the southern segment of Taihang Mountain.
Rabdosia rubescens aerial part is used as medicine, and has clearing heat and detoxicating, the effect of promoting blood circulation and stopping pain.Its well developed root system, sprout tiller strength is strong, and growth is rapid,
It is excellent soil-and-water conservation effect, is suitable for soil erosion and arid area as ecological economy plant Extend culture.This is for force
Peace is conceded the land to forestry, water and soil conservation and development Chinese medicine plantation, help farmer richness are of great significance.
But current Rabdosia rubescens product is mostly divided into two kinds: extract, Chinese herbal medicine formula, for the city of modernization
For life, essence powder is increasingly entering daily life, but is directed to Rabdosia rubescens, and there are no an existing techniques can
The dried frozen aquatic products of high quality are made.
Summary of the invention
The technical problem to be solved by the present invention is in the prior art, the difficult problem of Rabdosia rubescens finished product preparation provides one
Kind draws the technique of Rabdosia rubescens dried frozen aquatic products, achievees the purpose that improve Rabdosia rubescens product quality.
The present invention is achieved through the following technical solutions:
Rabdosia rubescens lyophiled powder preparing technique, it is characterised in that the following steps are included:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material；
(b) pulverizing process: Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud are carried out respectively using micronizer
It pulverizes, Ultramicro-powder particle emulsified material is made respectively；
(c) drying process: above-mentioned emulsified material being dried in freeze dryer respectively, and freeze-drying block is made；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, proportionally it is mixed and made into freeze-dried powder.
Freeze-drying is a kind of technology being dried using the principle of distillation, and being will be fast at low temperature by dry substance
Quick-frozen knot, then in vacuum environment appropriate, be directly sublimed into the hydrone freezed for vapor evolution process.Freezing is dry
Dry obtained product is referred to as lyophilized products (lyophilizer), which, which is referred to as, is lyophilized (lyophilization).Substance is in drying
It is preceding to be in low temperature (frozen state) always, while ice crystal is uniformly distributed in substance, sublimation process will not occur dense because of dehydration
Contracting phenomenon avoids and generates the side effects such as foam, oxidation by vapor.Dry matter is in dry sponge cellular, and volume is substantially not
Become, is highly soluble in water and restores to the original state.The physics and chemistry for preventing dry matter to the full extent and the denaturation in terms of biology.Freezing
Drying machine is made of refrigeration system, vacuum system, heating system, electrical instrumentation control system.Main component be drying box,
Coagulator, freezing unit, vacuum pump, heating/cooling device etc..Its working principle is will to be first frozen into three by dry article
Then phase point temperature hereinafter, make the solid-state moisture content (ice) in article be directly sublimed into vapor, from article under vacuum conditions
It excludes, keeps article dry.Material is admitted to quick-frozen storehouse and freezes after pre-treatment, dryness storehouse distillation dehydration is re-fed into, later rear
Handle workshop packaging.Vacuum system is that low air pressure condition is established in lyophilization storehouse, and heating system provides latent heat of sublimation, system to material
Cooling system provides required cooling capacity to cold-trap and hothouse.This equipment is heated using high efficient radiation, and material is heated evenly；Using height
Effect catches water cooling trap, and can realize quick defrost；Using high-efficiency vacuum unit, and it can realize water-oil separating；Using centralized system in parallel
Cooling system, multichannel cooling on demand, stable conditions, advantageous energy conservation；Using artificial intelligence control, precision height is controlled, it is easy to operate.It is glad
Instruct instrument net is to the quality requirement of freeze-dried products: bioactivity is constant, appearance luster is uniform, form is full, sound construction, molten
Solution speed is fast, and residual moisture is low.The product for obtaining high quality, theory and technique to freeze-drying should have one than more comprehensive
Solution.Lyophilized technique includes pre-freeze, distillation and three is lyophilized again stage by stage.But there are also a set of suitable Rabdosia rubescens dried frozen aquatic products so far
Production technology.Present applicant is engaged in research nearly 30 years of Rabdosia rubescens, for the habit of Rabdosia rubescens, ectogenesis,
The links such as quality control are reacted to, and on the basis of years of researches, there is new discovery: the plant production process of Rabdosia rubescens
In, active constituent content is highest be not Rabdosia rubescens leaf, but its bud, after blooming, the effective component of flower
Content sharply declines；The active constituent content of Rabdosia rubescens leaf is related with the variation of temperature during sunning, and
The curve of the active constituent content of leaf and bud variation is not identical.According to the above discovery, applicant has investigated a set of suitable
The technique for being suitable for rabdosia rubescens tea drink to be processed is raw material by using Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud,
The mode processed respectively, by different control technique come so that Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud
Dried frozen aquatic products respectively reach best in quality, and the mode then prepared again produces the high Rabdosia rubescens dried frozen aquatic products of quality, convenient for will
Rabdosia rubescens is promoted the use of as health care product.
In the step (a), fresh Rabdosia rubescens tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is plant
Top or side shoot top length are no more than the part of 8cm.In actual research process, discovery Rabdosia rubescens leaf has applicant
Effect ingredient is also variation, and compared with horn of plenty, and with the growth of time, the fiber in leaf increases the state in tender shoots,
Active constituent content decreases, and in order to ensure the quality of rabdosia rubescens tea product, needs to control the length of leaf, when the length of leaf
Less than 3cm, the content of effective ingredient Oridonin can just be protected.The top of plant or side shoot top length are no more than
The part of 8cm equally have it is higher should form part, and by the repetition test of many years, change the plant stalk of length, fiber
It can be crushed.
In the step (a), the entire length of Rabdosia rubescens bud is less than 7mm when stock.It has been investigated that blooming in bud
During, Rabdosia rubescens effective component content changes with the degree of bursting forth blossomed, and is analyzed according to experimental result and data, most
Determine that the entire length of bud is not greater than 7mm eventually, when length is greater than 7mm, bursting forth, it is shorter to bloom the required time, for
It is unfavorable to process；It can satisfy the demand of this technique, it is ensured that dry product by controlling the length of bud relative to entire processing technology
Quality.
Step (b) pulverizing process includes following three mutually indepedent steps:
(b1) Rabdosia rubescens tender leaf adds 1.0~1.2kg of water according to per kilogram raw material, and 2~2 μ are crushed in micronizer
m；
(b2) Rabdosia rubescens tip adds 0.9~1.1kg of water according to per kilogram raw material, and 6~10 μ are crushed in micronizer
m；
(b3) Rabdosia rubescens bud adds 0.8~1.0kg of water according to per kilogram raw material, and 4~8 μ are crushed in micronizer
m。
Applicant in many years it was found that, putting together and crushing if it is three kinds of positions, product
Quality hardly results in control, and applicant takes notice of this very much, then finds after study, is that each position is pulverized
When, it is required that being different, by up to ten thousand times grope, the optimal proportion of raw material and water has been summed up, in aforementioned proportion, system
At emulsified material uniform ingredients, the hole after freeze-drying is reasonable, is conducive to long-term preservation.
In the step (c) drying process include the steps that following three it is mutually indepedent:
(c1) emulsified material made from Rabdosia rubescens tender leaf is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -5 DEG C are reduced to according to 2~3 DEG C/minute of cooling rate, keeps the temperature 15-20 minutes, then with 0.01~0.02 standard
Atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；Normal atmosphere is boosted to after keeping the temperature 20-30 minutes
Pressure, then heats to 0 DEG C, and dried frozen aquatic products are made；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 12-18 minutes, then with 0.01~0.02 standard
Atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；Normal atmosphere is boosted to after keeping the temperature 10-15 minutes
Pressure, then heats to 0 DEG C, and dried frozen aquatic products are made；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 10-15 minutes, then with 0.01~0.02 standard
Atmospheric pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；Normal atmosphere is boosted to after keeping the temperature 20-25 minutes
Pressure, then heats to 0 DEG C, and dried frozen aquatic products are made.
For the lyophilization process of emulsified material, due to through being done frequently with the mode loaded in mixture in drying process originally
Dry, finished surface appearance obtained is different, and porosity is also different, its subsequent dissolution time of different porositys is not also identical,
Therefore, in order to improve the quality of product, it is arranged by carrying out different technique to each emulsified material, to obtain identical in quality
Product substantially increases the unitized of product, and the unification degree of especially appearance greatly improves.
It is configured when preparing dried frozen aquatic products in the step (d) according to following weight ratio, Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens
Tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=(1.5~2.5): (2.2~2.6): 1.
The weight ratio of dried frozen aquatic products is Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens in step (d)
Flower bud dried frozen aquatic products=2.2:2.5:1.
Aforementioned proportion is obtained on the analysis foundation of many years, according to Rabdosia rubescens freeze-dried powder made of this process,
Determination of oridonin relative to it is traditional dry, dry, the dry product that fixing method obtains is higher by 1.5 times or more.
Compared with prior art, the present invention having the following advantages and benefits:
1, Rabdosia rubescens lyophiled powder preparing technique of the present invention, by using Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud
For raw material, the mode processed respectively, by different control technique come so that Rabdosia rubescens tender leaf, Rabdosia rubescens tip, winter
The dried frozen aquatic products for insulting careless bud respectively reach best in quality, and the mode then prepared again produces the high Rabdosia rubescens freeze-drying of quality
Product, convenient for being promoted the use of Rabdosia rubescens as health care product；
2, Rabdosia rubescens lyophiled powder preparing technique of the present invention, the effective component of Rabdosia rubescens leaf is also variation, in tender
Compared with horn of plenty, and with the growth of time, the fiber in leaf increases the state of bud, and active constituent content decreases, in order to
The quality for ensuring rabdosia rubescens tea product needs to control the length of leaf, when the length of leaf is less than 3cm, the content of effective ingredient
It can just be protected.The top of plant or side shoot top length no more than the part of 8cm equally have it is higher should form part, and
By the repetition test of many years, change the plant stalk of length, fiber can be crushed；
3, Rabdosia rubescens lyophiled powder preparing technique of the present invention is arranged by carrying out different technique to each emulsified material, thus
Product identical in quality is obtained, substantially increases the unitized of product, the unification degree of especially appearance greatly improves.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is made below with reference to embodiment
Further to be described in detail, exemplary embodiment of the invention and its explanation for explaining only the invention, are not intended as to this
The restriction of invention.
Embodiment one
Rabdosia rubescens lyophiled powder preparing technique of the present invention, follows the steps below to implement:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material, the fresh winter is insulted
Careless tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is the portion of top or side shoot top length no more than 8cm of plant
Point；
(b1) pulverizing process: micronizer is used, Rabdosia rubescens tender leaf adds water 1kg according to per kilogram raw material, in Ultramicro-powder
2~2 μm are crushed in broken machine；
(b2) Rabdosia rubescens tip adds water 0.9kg according to per kilogram raw material, and 6~10 μm are crushed in micronizer；
(b3) Rabdosia rubescens bud adds water 1.0kg according to per kilogram raw material, and 4~8 μm are crushed in micronizer；
(c) drying process: emulsified material made from (c1) Rabdosia rubescens tender leaf is dry in this way in freeze dryer: under normal temperature state
Be put into freeze dryer, be reduced to -5 DEG C according to 2~3 DEG C/minute of cooling rate, keep the temperature 15 minutes, then with 0.01~
0.02 standard atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard after 25 minutes
Atmospheric pressure then heats to 0 DEG C, and dried frozen aquatic products are made；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 18 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 15 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 15 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 14 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, configured according to according to following weight ratio,
Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=(1.5~2.5): (2.2~2.6): 1,
After mixing, the unified product of quality is formed.
Embodiment two
Rabdosia rubescens lyophiled powder preparing technique of the present invention, follows the steps below to implement:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material, the fresh winter is insulted
Careless tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is the portion of top or side shoot top length no more than 8cm of plant
Point；
(b1) pulverizing process: micronizer is used, Rabdosia rubescens tender leaf adds water 1.1kg according to per kilogram raw material, in ultra micro
2~2 μm are crushed in pulverizer；
(b2) Rabdosia rubescens tip adds water 1.0kg according to per kilogram raw material, and 6~10 μm are crushed in micronizer；
(b3) Rabdosia rubescens bud adds water 0.9kg according to per kilogram raw material, and 4~8 μm are crushed in micronizer；
(c) drying process: emulsified material made from (c1) Rabdosia rubescens tender leaf is dry in this way in freeze dryer: under normal temperature state
Be put into freeze dryer, be reduced to -5 DEG C according to 2~3 DEG C/minute of cooling rate, keep the temperature 10 minutes, then with 0.01~
0.02 standard atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard after 25 minutes
Atmospheric pressure then heats to 0 DEG C, and dried frozen aquatic products are made；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 15 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 15 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 12 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 14 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, configured according to according to following weight ratio,
Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=(1.5~2.5): (2.2~2.6): 1,
After mixing, the unified product of quality is formed.
Embodiment three
Rabdosia rubescens lyophiled powder preparing technique of the present invention, follows the steps below to implement:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material, the fresh winter is insulted
Careless tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is the portion of top or side shoot top length no more than 8cm of plant
Point；
(b1) pulverizing process: micronizer is used, Rabdosia rubescens tender leaf adds water 1.1kg according to per kilogram raw material, in ultra micro
2~2 μm are crushed in pulverizer；
(b2) Rabdosia rubescens tip adds water 1.0kg according to per kilogram raw material, and 6~10 μm are crushed in micronizer；
(b3) Rabdosia rubescens bud adds water 1.0kg according to per kilogram raw material, and 4~8 μm are crushed in micronizer；
(c) drying process: emulsified material made from (c1) Rabdosia rubescens tender leaf is dry in this way in freeze dryer: under normal temperature state
Be put into freeze dryer, be reduced to -5 DEG C according to 2~3 DEG C/minute of cooling rate, keep the temperature 15 minutes, then with 0.01~
0.02 standard atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard after 25 minutes
Atmospheric pressure then heats to 0 DEG C, and dried frozen aquatic products are made；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 18 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 15 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 15 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 14 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, configured according to according to following weight ratio,
Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=(1.5~2.5): (2.2~2.6): 1,
After mixing, the unified product of quality is formed.
Example IV
Rabdosia rubescens lyophiled powder preparing technique of the present invention, follows the steps below to implement:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material, the fresh winter is insulted
Careless tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is the portion of top or side shoot top length no more than 8cm of plant
Point；
(b1) pulverizing process: micronizer is used, Rabdosia rubescens tender leaf adds water 1.2kg according to per kilogram raw material, in ultra micro
2~2 μm are crushed in pulverizer；
(b2) Rabdosia rubescens tip adds water 1.1kg according to per kilogram raw material, and 6~10 μm are crushed in micronizer；
(b3) Rabdosia rubescens bud adds water 0.8kg according to per kilogram raw material, and 4~8 μm are crushed in micronizer；
(c) drying process: emulsified material made from (c1) Rabdosia rubescens tender leaf is dry in this way in freeze dryer: under normal temperature state
Be put into freeze dryer, be reduced to -5 DEG C according to 2~3 DEG C/minute of cooling rate, keep the temperature 15 minutes, then with 0.01~
0.02 standard atmospheric pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard after 25 minutes
Atmospheric pressure then heats to 0 DEG C, and dried frozen aquatic products are made；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 18 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 15 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer under normal temperature state
In, -4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 15 minutes, it is then big with 0.01~0.02 standard
Air pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；The temperature is kept to boost to standard atmospheric pressure after 14 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, configured according to according to following weight ratio,
Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=(1.5~2.5): (2.2~2.6): 1,
After mixing, the unified product of quality is formed.
Comparative example five
The present embodiment is using the whole strain leaf of Rabdosia rubescens as raw material, after directly adding pigment broken, the dry work of directly freezed
Freeze-drying block is made in skill.
The product obtained for above method is identified, it is as follows to obtain data:
By carrying out analysis to above-mentioned data as can be seen that the Rabdosia rubescens that process according to the invention manufactures is lyophilized
Powder, the content of active principle Oridonin are apparently higher than product made from the prior art, have substantive distinguishing features outstanding
And significant progress, there is apparent Social benefit and economic benefit for the plantation popularization of Rabdosia rubescens.
Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects
It is described in detail, it should be understood that being not intended to limit the present invention the foregoing is merely a specific embodiment of the invention
Protection scope, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (6)
1. Rabdosia rubescens lyophiled powder preparing technique, it is characterised in that the following steps are included:
(a) procedure for preparation: using fresh Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud as raw material；
(b) Rabdosia rubescens tender leaf, Rabdosia rubescens tip, Rabdosia rubescens bud pulverizing process: are carried out respectively by ultra micro using micronizer
It crushes, Ultramicro-powder particle emulsified material is made respectively；
(c) drying process: above-mentioned emulsified material being dried in freeze dryer respectively, and freeze-drying block is made；
(d) hybrid packed, after step (c) freeze-drying block obtained is carried out coarse crushing, proportionally it is mixed and made into freeze-dried powder.
2. Rabdosia rubescens lyophiled powder preparing technique according to claim 1, it is characterised in that fresh in the step (a)
Rabdosia rubescens tender leaf is the blade that length is less than 3cm, and Rabdosia rubescens tip is that the top of plant or side shoot top length are no more than 8cm
Part.
3. Rabdosia rubescens lyophiled powder preparing technique according to claim 1, it is characterised in that step (b) the pulverizing process packet
Containing following three mutually indepedent steps:
(b1) Rabdosia rubescens tender leaf adds 1.0~1.2kg of water according to per kilogram raw material, and 2~2 μm are crushed in micronizer；
(b2) Rabdosia rubescens tip adds 0.9~1.1kg of water according to per kilogram raw material, and 6~10 μm are crushed in micronizer；
(b3) Rabdosia rubescens bud adds 0.8~1.0kg of water according to per kilogram raw material, and 4~8 μm are crushed in micronizer.
4. Rabdosia rubescens lyophiled powder preparing technique according to claim 1, it is characterised in that drying process in the step (c)
Include the steps that following three it is mutually indepedent:
(c1) emulsified material made from Rabdosia rubescens tender leaf is dry in this way in freeze dryer: being put into freeze dryer, presses under normal temperature state
- 5 DEG C are reduced to according to 2~3 DEG C/minute of cooling rate, keeps the temperature 15-20 minutes, then with 0.01~0.02 normal atmosphere
Pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；Standard atmospheric pressure is boosted to after keeping the temperature 20-30 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c2) emulsified material made from Rabdosia rubescens tip is dry in this way in freeze dryer: being put into freeze dryer, presses under normal temperature state
- 8 DEG C are reduced to according to 1~2 DEG C/minute of cooling rate, keeps the temperature 12-18 minutes, then with 0.01~0.02 normal atmosphere
Pressure/point pressure decay rate be depressurized to 0.1 standard atmospheric pressure；Standard atmospheric pressure is boosted to after keeping the temperature 10-15 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products；
(c3) emulsified material made from Rabdosia rubescens bud is dry in this way in freeze dryer: being put into freeze dryer, presses under normal temperature state
- 4 DEG C are reduced to according to 1~3 DEG C/minute of cooling rate, keeps the temperature 10-15 minutes, then with 0.01~0.02 normal atmosphere
Pressure/point pressure decay rate be depressurized to 0.2 standard atmospheric pressure；Standard atmospheric pressure is boosted to after keeping the temperature 20-25 minutes, so
After be warming up to 0 DEG C, be made dried frozen aquatic products.
5. Rabdosia rubescens lyophiled powder preparing technique according to claim 1, it is characterised in that prepare freeze-drying in the step (d)
It is configured when product according to following weight ratio, Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=
(1.5~2.5): (2.2~2.6): 1.
6. Rabdosia rubescens lyophiled powder preparing technique according to claim 5, it is characterised in that the weight of dried frozen aquatic products in step (d)
Ratio is Rabdosia rubescens tender leaf dried frozen aquatic products: Rabdosia rubescens tip dried frozen aquatic products: Rabdosia rubescens bud dried frozen aquatic products=2.2:2.5:1.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342195A (en) * | 2008-08-18 | 2009-01-14 | 张伟华 | Preparation method for traditional Chinese medicine micro powder article |
| CN104288227A (en) * | 2014-10-17 | 2015-01-21 | 王新华 | Novel drying method of fresh traditional Chinese medicine materials and application of dried traditional Chinese medicine materials |
| CN104739777A (en) * | 2013-12-25 | 2015-07-01 | 汤广武 | Preparation method of single traditional Chinese medicinal powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342195A (en) * | 2008-08-18 | 2009-01-14 | 张伟华 | Preparation method for traditional Chinese medicine micro powder article |
| CN104739777A (en) * | 2013-12-25 | 2015-07-01 | 汤广武 | Preparation method of single traditional Chinese medicinal powder |
| CN104288227A (en) * | 2014-10-17 | 2015-01-21 | 王新华 | Novel drying method of fresh traditional Chinese medicine materials and application of dried traditional Chinese medicine materials |
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