CN101342195A - Preparation method for traditional Chinese medicine micro powder article - Google Patents
Preparation method for traditional Chinese medicine micro powder article Download PDFInfo
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- CN101342195A CN101342195A CNA2008101389952A CN200810138995A CN101342195A CN 101342195 A CN101342195 A CN 101342195A CN A2008101389952 A CNA2008101389952 A CN A2008101389952A CN 200810138995 A CN200810138995 A CN 200810138995A CN 101342195 A CN101342195 A CN 101342195A
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Abstract
The present invention discloses a Chinese medicinal micropowder preparation method. The present invention includes the following procedures: (1) the required clean Chinese medicinal raw materials are ordinarily ground to obtain the powder; (2) the powder obtained in (1) is superfined to obtain the micropowder; (3) the micropowder obtained in (2) is placed in a container for water immersion and then decocted for 2 to 30 minutes to obtain the mature paste; (4) the paste obtained in (3) is placed in a microwave vacuum freeze dryer for drying; {5} the dried paste is placed in an ultra-fine pulverizer for ultra-fine pulverization, thus obtaining the Chinese medicinal micropowder. The preparation method provided by the present invention maintains the effect of the Chinese medicinal decoction, changes the taste according to the needs, fully utilizes all Chinese medicinal raw materials without herb residue and improves the medicine absorption of human body. The present invention has the advantages of simple process, easy operation, high production efficiency, Chinese medicinal material saving and low production cost.
Description
Technical field
The present invention relates to Chinese medicine, is a kind of preparation method of Chinese medicine micro powder article.
Background technology
Chinese medicine has passed through clinical proof in several thousand, and the raw material of Chinese medicine compatibility of its Cheng Fang is reasonable, and preparation method is proper, can reach the purpose for the treatment of both the principal and secondary aspects of a disease to numerous disease, and toxic and side effects is less.Many in the world countries are being familiar with the value of Chinese medicine gradually at present, and are progressively applying.Clinical proof in several thousand, the curative effect of Chinese medicine decoction is best, but since decoction prepare, take, mouthfeel, preserve, carry, there is more deficiency in many-side such as transportation, so, except the traditional decoction dosage form, various modern dosage forms such as Chinese medicinal tablet, electuary and capsule have been engendered on the present market.Though these modern formulations have mouthfeel good and be convenient to take, preserve, carry, advantage such as transportation, but because the process characteristic of manufacture process still has than big difference the curative effect of medicine with Chinese medicine decoction, and the crude drug cell sporoderm-broken rate is low, the Cytoplasm stripping is insufficient, cause the medical material utilization rate lower, cause bigger waste.Attempt to adopt the preparation method of Western medicine to prepare the extract oral dosage form to these those skilled in the art, to reach the purpose that improves the Chinese Traditional Medicines curative effect, through industry continuous practice for many years, prove that these methods involve great expense, the purpose of raising curative effect of medication difficulty reaches.
Summary of the invention
The objective of the invention is, a kind of preparation method of Chinese medicine micro powder article is provided, its method can be made various extract oral dosage forms as required when having kept the Chinese medicine decoction advantage, and improves the medical material utilization rate, to overcome the deficiencies in the prior art.
The present invention is achieved through the following technical solutions for achieving the above object: a kind of preparation method of Chinese medicine micro powder article may further comprise the steps:
1. required clean prescriptions of Chinese medicine raw material is carried out common pulverizing, obtain powder;
2. the powder that step is obtained in 1. carries out micronizing, obtains micro powder article;
3. the micro powder article of step in 2. inserted in inherent 20 ℃ of-70 ℃ of water of container and soak, the weight ratio of micro powder article and water is 1: 7-15, soak back decoction 2-30 minute, and obtain the mastic thing of ripening;
4. the mastic thing that step is obtained in is 3. inserted and is carried out drying in the microwave vacuum freeze drying machine;
5. dried mastic thing is inserted and carry out micronizing in the super micron mill, obtain the Chinese medicine micro powder article.
The 2. described micronizing of the preparation method of described a kind of Chinese medicine micro powder article, step adopts the vibration type super micron mill, and micro powder article is crossed 300 mesh sieve all-pass.
The crushed work temperature is 10 ℃-50 ℃ during the 2. described micronizing of the preparation method of described a kind of Chinese medicine micro powder article, step, and the pulverizing time is 10-40 minute.
The preparation method of described a kind of Chinese medicine micro powder article, the step 3. soak time of middle micro powder article are 10-60 minute.
The preparation method of described a kind of Chinese medicine micro powder article, the step container described in 3. is a fermentation tank, and fermentation tank is the normal temperature and pressure jar.
Operating temperature when carrying out drying in the 4. described microwave vacuum freeze drying machine of the preparation method of described a kind of Chinese medicine micro powder article, step is 0 ℃-70 ℃, and the dried water content of mastic thing is 1%-3%.
The preparation method of a kind of Chinese medicine micro powder article of the present invention, step 5. described in crushed work temperature during micronizing be 10 ℃-50 ℃, the pulverizing time is 10-100 second.
Chinese medicine micro powder article with the inventive method preparation can add as required and improve mouthfeel or dosage form desired additives, makes dosage forms such as Chinese medicine electuary, powder, tablet, pill and capsule.
Preparation method of the present invention and can be improved mouthfeel as required when having kept the Chinese medicine decoction effect, and can make various dosage forms, make take, preserve, carry, convenient transportation and practicality.Used raw material of Chinese medicine can all make full use of in the preparation method of the present invention, and no medicinal residues are discharged, and can improve the absorption of human body to medicine.Technological process of the present invention is succinct, easy operating, production efficiency height, save raw material of Chinese medicine, production cost is cheaper.
The specific embodiment
The preparation method of a kind of Chinese medicine micro powder article of the present invention, may further comprise the steps: 1. required clean prescriptions of Chinese medicine raw material is carried out common pulverizing, obtain powder, described prescriptions of Chinese medicine raw material is meant various raw material of Chinese medicine with therapeutic effect, and each raw material of Chinese medicine all should be put down in writing in the Chinese medicine voluminous dictionary; 2. the powder that step is obtained in 1. carries out micronizing, obtains micro powder article; 3. the micro powder article of step in 2. inserted in inherent 20 ℃ of-70 ℃ of water of container and soak, be generally normal-temperature water, the also water of available higher temperature when special circumstances, be advisable to be no more than 70 ℃, the weight ratio of micro powder article and water is 1: 7-15, micro powder article and water are stirred, and soak time is 10-60 minute usually, can reach the immersion purpose, but soak time also can increase, for example, also can be the 21-35 minute arbitrary time in one, or the 36-180 minute arbitrary time in one.Soak the back and decoct, decocting temperature is 100 ℃, decocts 2-30 minute, preferred: 2-10 minute, be as the criterion with the ripening of mastic thing, and obtain the mastic thing; 4. the mastic thing that step is obtained in is 3. inserted and is carried out drying in the microwave vacuum freeze drying machine, this operation can reach the purpose with cell wall breaking, sterilizing, drying and simplification technological process, operating temperature is 0 ℃-70 ℃, and the water content behind the dry materials is between the 1%-3%; 5. dried mastic thing is inserted and carry out micronizing in the super micron mill, the crushed work temperature is 10 ℃-50 ℃, and the pulverizing time is 10-100 second, obtains the Chinese medicine micro powder article.This Chinese medicine micro powder article is the active drug that can be used for various peroral dosage forms such as capsule, pill, tablet or powder.
The 2. described micronizing of step adopts the vibration type super micron mill in the inventive method, and micro powder article is crossed 300 mesh sieve all-pass, provides good basis for the immersion of an operation afterwards decocts.
In the inventive method during the 2. described micronizing of step the crushed work temperature be 10 ℃-50 ℃, the pulverizing time is 10-40 minute, to reach the optimum efficiency of micronizing.
The container of step described in 3. is fermentation tank, and fermentation tank is the normal temperature and pressure jar, and this is a kind of preferred version.With other container also can, but be that nonmetallic materials are best.
Operating temperature when carrying out drying in the 4. described microwave vacuum freeze drying machine of step of the present invention is 0 ℃-70 ℃, water content behind the mastic dry materials is 1%-3%, under vacuum state, control operating temperature≤70 ℃, the property of medicine that can keep the Chinese medicine micro powder article preferably, and the working time can effectively shorten drying the time.
Step 5. described in crushed work temperature during micronizing be 10 ℃-50 ℃, the pulverizing time is 10-100 second, can realize all in arbitrary time of this time period that the best of Chinese medicine micropowder is absorbed effect.
Preparation method of the present invention also can be used for the preparation of health product, and raw material of Chinese medicine is got final product with the health product raw material substitution.
Claims (7)
1, a kind of preparation method of Chinese medicine micro powder article is characterized in that: may further comprise the steps:
1. required clean prescriptions of Chinese medicine raw material is carried out common pulverizing, obtain powder;
2. the powder that step is obtained in 1. carries out micronizing, obtains micro powder article;
3. the micro powder article of step in 2. inserted in inherent 20 ℃ of-70 ℃ of water of container and soak, the weight ratio of micro powder article and water is 1: 7-15, soak back decoction 2-30 minute, and obtain the mastic thing of ripening;
4. the mastic thing that step is obtained in is 3. inserted and is carried out drying in the microwave vacuum freeze drying machine;
5. dried mastic thing is inserted and carry out micronizing in the super micron mill, obtain the Chinese medicine micro powder article.
2, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 is characterized in that: the 2. described micronizing of step adopts the vibration type super micron mill, and micro powder article is crossed 300 mesh sieve all-pass.
3, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 and 2 is characterized in that: the crushed work temperature is 10 ℃-50 ℃ during the 2. described micronizing of step, and the pulverizing time is 10-40 minute.
4, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 is characterized in that: the step 3. soak time of middle micro powder article is 10-60 minute.
5, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 is characterized in that: the container of step described in 3. is fermentation tank, and fermentation tank is the normal temperature and pressure jar.
6, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 is characterized in that: the operating temperature when carrying out drying in the 4. described microwave vacuum freeze drying machine of step is 0 ℃-70 ℃, and the dried water content of mastic thing is 1%-3%.
7, the preparation method of a kind of Chinese medicine micro powder article according to claim 1 and 2 is characterized in that: step 5. described in crushed work temperature during micronizing be 10 ℃-50 ℃, the pulverizing time is 10-100 second.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101389952A CN101342195B (en) | 2008-08-18 | 2008-08-18 | Preparation method for traditional Chinese medicine micro powder article |
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| CN2008101389952A CN101342195B (en) | 2008-08-18 | 2008-08-18 | Preparation method for traditional Chinese medicine micro powder article |
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| CN101342195A true CN101342195A (en) | 2009-01-14 |
| CN101342195B CN101342195B (en) | 2011-01-05 |
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| CN2008101389952A Expired - Fee Related CN101342195B (en) | 2008-08-18 | 2008-08-18 | Preparation method for traditional Chinese medicine micro powder article |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173388A (en) * | 2014-05-26 | 2014-12-03 | 王亦能 | Method for preparing cultured cordyceps sinensis mycelium lyophilized powder |
| CN104547616A (en) * | 2014-12-31 | 2015-04-29 | 广东东阳光药业有限公司 | Traditional Chinese medicine tablet and preparation method thereof |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN109512859A (en) * | 2019-01-29 | 2019-03-26 | 韩佳妹 | Rabdosia rubescens lyophiled powder preparing technique |
| CN110403977A (en) * | 2018-04-27 | 2019-11-05 | 江西江中中药饮片有限公司 | The preparation method and application of pueraria lobata micro mist |
| CN113350248A (en) * | 2021-05-27 | 2021-09-07 | 贵州省农作物品种资源研究所 | Preparation and application method of bletilla striata gel freeze-dried powder skin moisturizer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1471961A (en) * | 2003-06-30 | 2004-02-04 | 李建立 | Method for preparing Chinese medicine decoction by ultramicro cracking technology |
-
2008
- 2008-08-18 CN CN2008101389952A patent/CN101342195B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173388A (en) * | 2014-05-26 | 2014-12-03 | 王亦能 | Method for preparing cultured cordyceps sinensis mycelium lyophilized powder |
| CN104547616A (en) * | 2014-12-31 | 2015-04-29 | 广东东阳光药业有限公司 | Traditional Chinese medicine tablet and preparation method thereof |
| CN110403977A (en) * | 2018-04-27 | 2019-11-05 | 江西江中中药饮片有限公司 | The preparation method and application of pueraria lobata micro mist |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN109512859A (en) * | 2019-01-29 | 2019-03-26 | 韩佳妹 | Rabdosia rubescens lyophiled powder preparing technique |
| CN113350248A (en) * | 2021-05-27 | 2021-09-07 | 贵州省农作物品种资源研究所 | Preparation and application method of bletilla striata gel freeze-dried powder skin moisturizer |
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| Publication number | Publication date |
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| CN101342195B (en) | 2011-01-05 |
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