CN109476698B - 基于基因的炎性肠病诊断 - Google Patents
基于基因的炎性肠病诊断 Download PDFInfo
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- CN109476698B CN109476698B CN201780044934.7A CN201780044934A CN109476698B CN 109476698 B CN109476698 B CN 109476698B CN 201780044934 A CN201780044934 A CN 201780044934A CN 109476698 B CN109476698 B CN 109476698B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
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- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311263442.0A CN117286238A (zh) | 2016-05-20 | 2017-05-19 | 基于基因的炎性肠病诊断 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339357P | 2016-05-20 | 2016-05-20 | |
| US62/339,357 | 2016-05-20 | ||
| PCT/US2017/033625 WO2017201461A1 (en) | 2016-05-20 | 2017-05-19 | Diagnosis of inflammatory bowel disease based on genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311263442.0A Division CN117286238A (zh) | 2016-05-20 | 2017-05-19 | 基于基因的炎性肠病诊断 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109476698A CN109476698A (zh) | 2019-03-15 |
| CN109476698B true CN109476698B (zh) | 2023-10-17 |
Family
ID=60326226
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780044934.7A Active CN109476698B (zh) | 2016-05-20 | 2017-05-19 | 基于基因的炎性肠病诊断 |
| CN202311263442.0A Pending CN117286238A (zh) | 2016-05-20 | 2017-05-19 | 基于基因的炎性肠病诊断 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311263442.0A Pending CN117286238A (zh) | 2016-05-20 | 2017-05-19 | 基于基因的炎性肠病诊断 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11549146B2 (https=) |
| EP (1) | EP3458466B1 (https=) |
| JP (4) | JP7475811B2 (https=) |
| KR (4) | KR102481305B1 (https=) |
| CN (2) | CN109476698B (https=) |
| WO (1) | WO2017201461A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
| KR102481305B1 (ko) * | 2016-05-20 | 2022-12-26 | 세다르스-신나이 메디칼 센터 | 유전자에 기반한 염증성 장 질환의 진단 |
| WO2020112890A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| JP2022533956A (ja) | 2019-05-14 | 2022-07-27 | プロメテウス バイオサイエンシーズ,インク. | Tl1a患者を選択する方法、システム、およびデバイス |
| CN116322762A (zh) * | 2020-06-26 | 2023-06-23 | 辉瑞公司 | 用tl1a抗体治疗炎症性肠病的方法 |
| CA3197828A1 (en) * | 2020-11-13 | 2022-05-19 | Laurens Kruidenier | Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a |
| CN115851911B (zh) * | 2022-11-25 | 2025-10-24 | 南京鼓楼医院 | 一种用于鉴别狼疮性肾炎的尿液外泌体tsRNA标志物和探针及其应用 |
| EP4646434A2 (en) * | 2023-01-06 | 2025-11-12 | Prometheus Biosciences, Inc. | Methods of treating inflammatory diseases with combination of tl1a inhibitors and tnf inhibitors |
| CN121843714A (zh) | 2023-08-11 | 2026-04-10 | 派拉冈医疗公司 | Tl1a结合抗体及使用方法 |
Citations (15)
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| WO2000006768A1 (en) * | 1998-07-25 | 2000-02-10 | Astrazeneca Ab | Genetic polymorphisms in the human neurokinin 1 receptor gene and their uses in diagnosis and treatment of diseases |
| CN1890384A (zh) * | 2003-10-06 | 2007-01-03 | 诺瓦提斯公司 | 与炎性疾病的治疗功效相关的遗传多态性的用途 |
| WO2007073478A2 (en) * | 2005-12-19 | 2007-06-28 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| WO2008106451A2 (en) * | 2007-02-26 | 2008-09-04 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2009039244A2 (en) * | 2007-09-18 | 2009-03-26 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| CN101688239A (zh) * | 2007-02-12 | 2010-03-31 | 约翰·霍普金斯大学 | 结肠癌的早期检测和预后 |
| WO2010062960A2 (en) * | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| WO2011088380A1 (en) * | 2010-01-15 | 2011-07-21 | Cedars-Sinai Medical Center | Methods of using fut2 genetic variants to diagnose crohn's disease |
| US20110217310A1 (en) * | 2007-01-10 | 2011-09-08 | Siegel Richard M | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology |
| WO2011153501A2 (en) * | 2010-06-04 | 2011-12-08 | Prometheus Laboratories Inc. | Methods for improving inflammatory bowel disease diagnosis |
| WO2014186750A2 (en) * | 2013-05-17 | 2014-11-20 | Cedars-Sinai Medical Center | Variants of tnfsf15 and dcr3 associated with crohn's disease |
| CN104204230A (zh) * | 2012-02-10 | 2014-12-10 | 诺和诺德A/S(股份有限公司) | 治疗炎性疾病和病症的相关方法 |
| WO2015054529A1 (en) * | 2013-10-09 | 2015-04-16 | Cedars-Sinai Medical Center | Diagnosis and treatment of irritable bowel syndrome and inflammatory bowel disease |
| CN104805198A (zh) * | 2008-08-12 | 2015-07-29 | 金帆德尔制药股份有限公司 | 鉴定疾病风险因子的方法 |
| HK1200933A1 (zh) * | 2011-10-21 | 2015-08-14 | Nestec S.A. | 改善炎性肠病诊断的方法 |
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2017
- 2017-05-19 KR KR1020227003985A patent/KR102481305B1/ko active Active
- 2017-05-19 US US16/303,033 patent/US11549146B2/en active Active
- 2017-05-19 JP JP2018560186A patent/JP7475811B2/ja active Active
- 2017-05-19 WO PCT/US2017/033625 patent/WO2017201461A1/en not_active Ceased
- 2017-05-19 KR KR1020247019512A patent/KR20240095363A/ko not_active Ceased
- 2017-05-19 CN CN201780044934.7A patent/CN109476698B/zh active Active
- 2017-05-19 CN CN202311263442.0A patent/CN117286238A/zh active Pending
- 2017-05-19 KR KR1020227044940A patent/KR20230003433A/ko not_active Ceased
- 2017-05-19 KR KR1020187037151A patent/KR20190016972A/ko not_active Ceased
- 2017-05-19 EP EP17800279.6A patent/EP3458466B1/en active Active
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2022
- 2022-03-18 JP JP2022044738A patent/JP7392020B2/ja active Active
- 2022-12-09 US US18/063,931 patent/US12545959B2/en active Active
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2023
- 2023-12-18 JP JP2023213224A patent/JP2024037945A/ja active Pending
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2025
- 2025-11-25 JP JP2025203084A patent/JP2026048696A/ja active Pending
Patent Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000006768A1 (en) * | 1998-07-25 | 2000-02-10 | Astrazeneca Ab | Genetic polymorphisms in the human neurokinin 1 receptor gene and their uses in diagnosis and treatment of diseases |
| CN1890384A (zh) * | 2003-10-06 | 2007-01-03 | 诺瓦提斯公司 | 与炎性疾病的治疗功效相关的遗传多态性的用途 |
| WO2007073478A2 (en) * | 2005-12-19 | 2007-06-28 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| US20110217310A1 (en) * | 2007-01-10 | 2011-09-08 | Siegel Richard M | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology |
| CN101688239A (zh) * | 2007-02-12 | 2010-03-31 | 约翰·霍普金斯大学 | 结肠癌的早期检测和预后 |
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| CN104805198A (zh) * | 2008-08-12 | 2015-07-29 | 金帆德尔制药股份有限公司 | 鉴定疾病风险因子的方法 |
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| WO2011153501A2 (en) * | 2010-06-04 | 2011-12-08 | Prometheus Laboratories Inc. | Methods for improving inflammatory bowel disease diagnosis |
| HK1200933A1 (zh) * | 2011-10-21 | 2015-08-14 | Nestec S.A. | 改善炎性肠病诊断的方法 |
| CN104204230A (zh) * | 2012-02-10 | 2014-12-10 | 诺和诺德A/S(股份有限公司) | 治疗炎性疾病和病症的相关方法 |
| WO2014186750A2 (en) * | 2013-05-17 | 2014-11-20 | Cedars-Sinai Medical Center | Variants of tnfsf15 and dcr3 associated with crohn's disease |
| WO2015054529A1 (en) * | 2013-10-09 | 2015-04-16 | Cedars-Sinai Medical Center | Diagnosis and treatment of irritable bowel syndrome and inflammatory bowel disease |
Non-Patent Citations (6)
| Title |
|---|
| HIDETOSHI TAKEDATSU等.TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation.《GASTROENTEROLOGY》.2008,第135卷552-567. * |
| Reversal of Murine Colitis and Fibrosis by Neutralizing TL1A Antibody: Potential Novel Therapy to Alter Natural History of Crohn"s Disease;David Q. Shih等;《Gastroenterology》;20120531;第142卷(第5期);S-84 * |
| rs918490;佚名;《dbSNP》;20080526;1-9 * |
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| KR20220025122A (ko) | 2022-03-03 |
| US20190194754A1 (en) | 2019-06-27 |
| EP3458466B1 (en) | 2024-08-07 |
| KR20240095363A (ko) | 2024-06-25 |
| JP2024037945A (ja) | 2024-03-19 |
| JP7392020B2 (ja) | 2023-12-05 |
| KR102481305B1 (ko) | 2022-12-26 |
| JP2026048696A (ja) | 2026-03-17 |
| EP3458466A4 (en) | 2020-03-04 |
| KR20190016972A (ko) | 2019-02-19 |
| JP7475811B2 (ja) | 2024-04-30 |
| CN117286238A (zh) | 2023-12-26 |
| KR20230003433A (ko) | 2023-01-05 |
| US11549146B2 (en) | 2023-01-10 |
| JP2022095688A (ja) | 2022-06-28 |
| US20230366028A1 (en) | 2023-11-16 |
| JP2019516375A (ja) | 2019-06-20 |
| WO2017201461A1 (en) | 2017-11-23 |
| CN109476698A (zh) | 2019-03-15 |
| US12545959B2 (en) | 2026-02-10 |
| EP3458466A1 (en) | 2019-03-27 |
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