CN109452269A - Avermectin emulsion formulations and preparation method and application - Google Patents
Avermectin emulsion formulations and preparation method and application Download PDFInfo
- Publication number
- CN109452269A CN109452269A CN201811573725.4A CN201811573725A CN109452269A CN 109452269 A CN109452269 A CN 109452269A CN 201811573725 A CN201811573725 A CN 201811573725A CN 109452269 A CN109452269 A CN 109452269A
- Authority
- CN
- China
- Prior art keywords
- pesticidal preparations
- avermectin
- organic solvent
- propylene
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Abstract
The present invention provides avermectin emulsion formulations, and preparation method and application.Specifically, the present invention provides a kind of pesticidal preparations, the pesticidal preparations contain the component of following weight ratio: 0.1-10wt% avermectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% stabilizer and water, wherein the organic solvent includes propylene-glycol diacetate and methylene dicarbamate.Pesticidal preparations of the present invention kill that effect is good, the lasting period is long, quick-acting is good to pest, have good repellent action and lethal effect to pest, and insecticidal spectrum is wide, easy to use, cost is relatively low, safe and reliable, have the characteristics that efficiently, low toxicity, low cost pesticide.
Description
Technical field
The invention belongs to pesticide field, in particular it relates to avermectin emulsion formulations, and preparation method thereof and answer
With.
Background technique
Avermectin is a kind of agricultural or for animals sterilization being widely used, Insecticidal and acaricidal agent.It is big by Japanese North university
One kind that village's intelligence etc. and U.S. Merck company develop first have sterilization, desinsection, mite killing, eelworm-killing activity ten hexa-atomic big rings
Lactone disaccharide compound is the natural products separated from edaphon.There is stomach toxicity and action of contace poison to insect and mite class,
And have faint fumigation action, no systemic action.Mechanism of action interferes nervous physiology activity unlike general insecticide, thorn
Swash release γ-aminobutyric acid, and aminobutyric acid has inhibiting effect to the nerve conduction of arthropod.Mite class adult, nymph and elder brother
There is paralysis symptom in worm larva after contacting with avermectin, inactive, not feeding is dead after 2~4 days.Because not causing insect
Rapid dehydration, so avermectin lethal effect is slower.Though avermectin has direct touching to insect predator and insect parasite
The effect of killing, but because plant surface residual is few, therefore to the damage very little of beneficial insect.Avermectin will not be moved in soil by adsorption by soil
It is dynamic, and be decomposed by the microorganisms, thus in the environment without cumulative function, it can be used as a component part of integrated control.
In recent years, with the needs of the raising of environmental consciousness and sustainable development, the requirement to the formulations of pesticide is higher and higher,
Especially develop towards the direction of synergy, sustained release, safety, then to the transformation that traditional formulations of pesticide upgrade, invention
The cry of novel form is higher and higher.Although the microemulsion of avermectin has a wide range of applications, because not having sustained release performance
And the lasting period is caused not grow, and use the toxic solvents such as cyclohexanone, n,N-Dimethylformamide.Therefore, how to improve and obtain
It is to have technical problem to be solved with sustained release performance, safety and environmental protection.
Summary of the invention
The object of the present invention is to provide a kind of avermectin pesticides preparation with sustained release performance, safety and environmental protection.
The first aspect of the present invention provides a kind of pesticidal preparations, with pesticidal preparations total weight, the pesticidal preparations packet
Include following components: 0.1-10wt% avermectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% stabilizer
And water, wherein the organic solvent includes propylene-glycol diacetate and methylene dicarbamate.
In another preferred example, the content of the organic solvent is 10-40wt%, preferably 15-37.5wt%, by pesticide
The total weight of preparation.
In another preferred example, the total content of the propylene-glycol diacetate and methylene dicarbamate is at least
25wt%, preferably 40-80wt%, more preferably 50-65wt%, by the total weight of organic solvent.
In another preferred example, the weight ratio of the propylene-glycol diacetate and methylene dicarbamate is 10:1-
1:1, preferably 8:1-2:1.
In another preference, the content of the propylene-glycol diacetate is at least 20wt%, preferably 30-80wt%,
It is more preferably 40-60wt%, by the total weight of organic solvent.
In another preferred example, the content of the methylene dicarbamate is at least 5w%, preferably 6-20wt%,
It is more preferably 10-15wt%, by the total weight of organic solvent.
In another preferred example, the organic solvent, which also contains, one of is selected from the group or a variety of: N- ethyl pyrrolidine
Ketone, dimethyl sulfoxide, N, N- dimethyldecamide, N, N- dimethyl-octa certain herbaceous plants with big flowers amide.
In another preferred example, the organic solvent contains propylene-glycol diacetate, methylene dicarbamate, N- ethyl
Pyrrolidones, dimethyl sulfoxide, and also contain spectrasolv DMDA and N, one of N- dimethyl-octa certain herbaceous plants with big flowers amide or
Two kinds.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, the N- dimethyl last of the ten Heavenly stems
Amide.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, N- dimethyl-octa
Certain herbaceous plants with big flowers amide.
In another preferred example, the total content of the propylene-glycol diacetate and methylene dicarbamate is 6-
40wt%, preferably 11.5-26wt%, by the total weight of pesticidal preparations.
In another preference, the content of the propylene-glycol diacetate is 5-30wt%, and preferably 10-20wt% is pressed
The total weight of pesticidal preparations.
In another preferred example, the content of the methylene dicarbamate be 1-10w%, preferably 1.5-6wt%,
By the total weight of pesticidal preparations.
In another preferred example, the content of the avermectin is 0.1-10wt%, preferably 1-5wt%, by pesticide system
The total weight of agent.
In another preferred example, the avermectin includes AVERMECTIN B1 and/or Avermectin B2.
In another preferred example, the AVERMECTIN B1 includes Avermectin B1a and/or avermectin B1b.
In another preferred example, the Avermectin B2 includes avermectin B2a and/or Avermectin B2 b.
In another preferred example, the content of the emulsifier is 10-20wt%, by the total weight of pesticidal preparations.
In another preferred example, the emulsifier one of is selected from the group or a variety of (preferably 2,3,4,5 kind): triphen
Vinyl benzene phenol polyethenoxy ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether, anacardol polyoxy
Vinethene, non-ionic hydroxyl polyethylene oxide block copolymer.
In another preferred example, the emulsifier contains tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxy
Ethylene polyethenoxy ether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether and non-ionic hydroxyl poly-ethylene oxide block
At least three kinds in copolymer.
In another preferred example, the emulsifier contains tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxy
Ethylene polyethenoxy ether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether and non-ionic hydroxyl poly-ethylene oxide block
Copolymer.
In another preferred example, in parts by weight, the emulsifier contains 2-8 parts of triphenyl vinyl phenol polyoxyethylene
Ether, 2-8 parts of phenethyl phenol polyoxyethylene poly-oxygen propylene aethers, 1-2 parts of fatty alcohol polyoxyethylene ether, 1-2 parts of anacardol polyoxy second
Alkene ether and 1-2 parts of non-ionic hydroxyl polyethylene oxide block copolymers.
In another preferred example, the stabilizer is selected from the group: 2,6- toluene di-tert-butyl phenols (BHT), butylhydroxy
Anisole (BHA), tert-butylhydroquinone (TBHQ), triethyl citrate (TEC), vitamin C, or combinations thereof.
In another preferred example, the pesticidal preparations further include: synergist, vegetable oil, or combinations thereof.
In another preferred example, the synergist is selected from the group: azone, thiophene ketone, aerosol OT, organosilicon
Polyoxyethylene ether, or combinations thereof.
In another preferred example, the content of the synergist is 0.5-5wt%, preferably 1-3wt%, by pesticidal preparations
Total weight.
In another preferred example, the vegetable oil is selected from the group: oleic acid, methylation methyl oleate, ethylization methyl oleate,
Castor oil, eucalyptus oil, olive oil, cashew nut shell oil, or combinations thereof.
In another preferred example, the content of the vegetable oil is 0.05-5wt%, preferably 0.1-2wt%, by pesticide system
The total weight of agent.
In another preferred example, the pesticidal preparations also contain: synergist, vegetable oil, dispersing agent, wetting agent, antifreezing agent,
Defoaming agent, pH adjusting agent, thickener, or combinations thereof.
In another preferred example, the total weight based on the pesticidal preparations, the pesticidal preparations include following components:
Avermectin 1-10wt%, it organic solvent 10-40wt%, emulsifier 10-20wt%, stabilizer 0.5-3wt%, plants
Object oil 0.1-2wt%, synergist 1-5wt%, dispersing agent 1-3wt%, antifreezing agent 3-5wt%, defoaming agent 0.01-0.05wt%,
With the water of surplus.
In another preferred example, based on the total weight of pesticidal preparations, the pesticidal preparations are mainly by the group of following weight ratio
It is grouped as:
Avermectin 1-10wt%, it organic solvent 10-40wt%, emulsifier 10-20wt%, stabilizer 0.5-3wt%, plants
Object oil 0.1-2wt%, synergist 1-5wt%, dispersing agent 1-3wt%, antifreezing agent 3-5wt%, defoaming agent 0.01-0.05wt%,
With the water of surplus.
In another preferred example, the dispersing agent is phosphoric acid salt anionic dispersing agents.
In another preferred example, the antifreezing agent is selected from the group: urea, ethylene glycol, propylene glycol, glycerine, or combinations thereof.
In another preferred example, the defoaming agent be dimethicone, isomery alcohol ether, or combinations thereof.
In another preferred example, the sum of each component content is 100% in the pesticidal preparations.
In another preferred example, described " each component " further includes above-mentioned other components.
In another preferred example, the pesticidal preparations are liquid preparation, preferably emulsion formulations.
In another preferred example, the emulsion formulations include: microemulsion, aqueous emulsion or missible oil, preferably microemulsion.
In another preferred example, the partial size of the microemulsion is 1-100nm, preferably 15-50nm.
The second aspect of the present invention provides pesticidal preparations described in first aspect present invention in prevention and treatment harmful organism
Using.
In another preferred example, the harmful organism is selected from the group: lepidoptera pest, mite class, nematode, or combinations thereof.
In another preferred example, for preventing and/or inhibiting harmful organism on agricultural, forestry or gardening.
The third aspect of the present invention provides a kind of preparation method of pesticidal preparations, the method includes the steps:
(a) 0.01-10wt% avermectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% is steady
Agent, water and optional auxiliary agent mixing are determined, wherein the organic solvent includes propylene-glycol diacetate and methyl carbamic acid first
Ester obtains mixture；With
(b) mixture in step (a) is emulsified, obtains the pesticidal preparations.
In another preferred example, the auxiliary agent is selected from the group: synergist, dispersing agent, wetting agent, antifreezing agent, disappears at vegetable oil
Infusion, pH adjusting agent, thickener, or combinations thereof.
In another preferred example, it the described method comprises the following steps:
(1) avermectin, organic solvent, vegetable oil, synergist, stabilizer, emulsifier and defoaming agent are mixed, obtains oil
Phase；
(2) dispersing agent, antifreezing agent and water are mixed, obtains water phase；
(3) water phase is mixed and is emulsified with the oil, the pesticidal preparations are made.
In another preferred example, in step (b), the revolving speed of the emulsification is 1000-2500rpm.
In another preferred example, in step (b), the time of the emulsification is 30-60min.
The fourth aspect of the present invention provides a kind of organic solvent, and with organic solvent total weight, the organic solvent contains
Have:
(a) 30-80 parts, preferably 40-60 parts of propylene-glycol diacetate；
(b) 6-20 parts, preferably 10-15 parts of methylene dicarbamate；And optional
(c) N- ethyl pyrrolidone, dimethyl sulfoxide, N, in N- dimethyldecamide and N, N- dimethyl-octa certain herbaceous plants with big flowers amide
It is one or more.
In another preferred example, the total content of the propylene-glycol diacetate and methylene dicarbamate is at least
25wt%, preferably 40-80wt%, more preferably 50-65wt%, by the total weight of organic solvent.
In another preferred example, the weight ratio of the propylene-glycol diacetate and methylene dicarbamate is 10:1-
1:1, preferably 8:1-2:1.
In another preference, the content of the propylene-glycol diacetate is at least 20wt%, preferably 30-80wt%,
It is more preferably 40-60wt%, by the total weight of organic solvent.
In another preferred example, the content of the methylene dicarbamate is at least 5w%, preferably 6-20wt%,
It is more preferably 10-15wt%, by the total weight of organic solvent.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, the N- dimethyl last of the ten Heavenly stems
Amide.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, N- dimethyl-octa
Certain herbaceous plants with big flowers amide.
The fifth aspect of the present invention provides the purposes of organic solvent as described in the fourth aspect of the present invention, is used to prepare
Pesticidal preparations.
In another preferred example, the pesticidal preparations are avermectin pesticides preparation.
It should be understood that above-mentioned each technical characteristic of the invention and having in below (eg embodiment) within the scope of the present invention
It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist
This no longer tires out one by one states.
Specific embodiment
The present inventor after extensive and in-depth study, is surprised to find that for the first time containing propylene-glycol diacetate, methyl ammonia
The organic solvent of base methyl formate especially contains propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidine
The organic solvent of ketone, dimethyl sulfoxide and N, N- dimethyldecamide or N, N- dimethyl-octa certain herbaceous plants with big flowers amide can dissolve well Ah
Rhzomorph is tieed up, significantly improves insecticidal effect and the lasting period of avermectin, and environmental pollution is few, toxicity is low, safe, very
It is suitable as the novel solvent of avermectin.In addition, the combination of organic solvent of the present invention and emulsifier can make the Avermectin of preparation
Plain lotion oil bead diameter reaches nanoscale, and dilution particles ultra fine is micro-, is conducive to medical fluid in the adherency and deposition of blade surface, hence it is evident that
It improves the infiltration to target plant and holds dose, to reduce Pesticide use amount.Pesticidal preparations of the present invention kill pest
Effect is good, the lasting period is long, quick-acting is good, has a good repellent action and lethal effect to pest, insecticidal spectrum is wide, it is easy to use,
Cost is relatively low, safe and reliable, has the characteristics of efficient, low toxicity, inexpensive pesticide.On this basis, inventor completes this
Invention.
Term explanation
Unless otherwise defined, otherwise whole technologies used herein and scientific term all have such as fields of the present invention
The normally understood identical meanings of those of ordinary skill.
As used herein, in use, term " about " means that the value can be from enumerating in mentioning the numerical value specifically enumerated
Value changes not more than 1%.For example, as used herein, statement " about 100 " include 99 and 101 and between whole values (for example,
99.1,99.2,99.3,99.4 etc.).
As used herein, term " containing " or " including (including) " can be open, semi-enclosed and enclosed.It changes
Yan Zhi, the term also include " substantially by ... constitute " or " by ... constitute ".
Avermectin
The structure of avermectin is as shown in following formula I:
Avermectin appearance be it is faint yellow to white crystalline powder, it is tasteless.Density: 1.16；It is molten: 150~155 DEG C；Steam
Pressure: 2 × 10-7Pa；Relative density 1.16 (21 DEG C)；Specific rotatory power: D+55.7 ± 2 ° (c=0.87in CHCl3)；Solubility (21
DEG C): toluene 350g/L, acetone 100g/L, isopropanol 70g/L, chloroform 25g/L, ethyl alcohol 20g/L, methanol 19.5g/L, hexamethylene
6g/L, kerosene 0.5g/L, 10 μ g/L of water.Distribution coefficient: 9.9 × 103.Stability: stablizing under normal condition, when pH value 5~9 not
It can hydrolyze.
Avermectin has stomach toxicity and action of contace poison to mite class and insect, is unable to ovicidal.Mechanism of action and general insecticide
The difference is that nervous physiology activity is interfered, stimulation release γ-aminobutyric acid, and aminobutyric acid has the nerve conduction of arthropod
Inhibiting effect.There is paralysis symptom in mite class adult, nymph and insect larvae after contacting with avermectin, inactive, not feeding,
It is dead after 2~4 days.Because not causing insect rapid dehydration, so avermectin lethal effect is slower.Avermectin is to predatism
Though insect and insect parasite have direct action of contace poison, because plant surface residual is few, therefore to the damage very little of beneficial insect.Avermectin
Element will not be moved in soil by adsorption by soil, and be decomposed by the microorganisms, thus in the environment without cumulative function, it can be used as comprehensive
Close a component part of prevention and treatment.Modulation is easy, and can be used slightly stirring in the preparation water of falling people, also safer to crop,
Phytotoxicity will not occur by the method use of introduction.Applicable crops vegetables, citrus, cotton etc..
Controlling object: antagonism pest has special efficacy, such as diamondback moth, leaf miner, red spider.
Application technology: avermectin has stomach toxicity and action of contace poison to mite class and insect, and permeability is strong, and medical fluid is sprayed onto plant
It is rapidly permeated into behind blade face and forms numerous miniature anther sacs, the adult of mite class, the larval feeding of nymph and insect and contact in mesophyll
Occurs paralysis symptom after medical fluid immediately, inactive, not feeding is dead after 2~4 days.The medicament pole on avermectin residual blade face
It is few, and it is broken down into innocuous substance quickly, so lethal to natural enemy small.Avermectin does not have ovicidal action.
Avermectin is a kind of agricultural or for animals sterilization being widely used, Insecticidal and acaricidal agent.It is big by Japanese North university
One kind that village's intelligence etc. and U.S. Merck company develop first have sterilization, desinsection, mite killing, eelworm-killing activity ten hexa-atomic big rings
Lactone disaccharide compound is the natural products separated from edaphon.There is stomach toxicity and action of contace poison to insect and mite class,
And have faint fumigation action, no systemic action.Mechanism of action interferes nervous physiology activity unlike general insecticide, thorn
Swash release γ-aminobutyric acid, and aminobutyric acid has inhibiting effect to the nerve conduction of arthropod.Mite class adult, nymph and elder brother
There is paralysis symptom in worm larva after contacting with avermectin, inactive, not feeding is dead after 2~4 days.Because not causing insect
Rapid dehydration, so avermectin lethal effect is slower.Though avermectin has direct touching to insect predator and insect parasite
The effect of killing, but because plant surface residual is few, therefore to the damage very little of beneficial insect.Avermectin will not be moved in soil by adsorption by soil
It is dynamic, and be decomposed by the microorganisms, thus in the environment without cumulative function, it can be used as a component part of integrated control.
Organic solvent
In the present invention, in the pesticidal preparations, the content of the organic solvent is 5-45wt%, preferably 10-
40wt%, more preferably 15-37.5wt%, by the total weight of pesticidal preparations.
In the present invention, the organic solvent includes propylene-glycol diacetate and methylene dicarbamate.Organic molten
In agent, the total content of the propylene-glycol diacetate and methylene dicarbamate is at least 25wt%, preferably 40-
80wt%, more preferably 50-65wt%, by the total weight of organic solvent.
In another preferred example, the weight ratio of the propylene-glycol diacetate and methylene dicarbamate is 10:1-1:
1, preferably 8:1-2:1.
In another preferred example, in organic solvent, the content of the propylene-glycol diacetate is at least 20wt%, preferably
Ground is 30-80wt%, is more preferably 40-60wt%, by the total weight of organic solvent.
In another preferred example, in organic solvent, the content of the methylene dicarbamate is at least 5w%, preferably
Ground is 6-20wt%, is more preferably 10-15wt%, by the total weight of organic solvent.
In another preferred example, the organic solvent, which also contains, one of is selected from the group or a variety of: N- ethyl pyrrolidine
Ketone, dimethyl sulfoxide, N, N- dimethyldecamide, N, N- dimethyl-octa certain herbaceous plants with big flowers amide.
In another preferred example, the organic solvent contains propylene-glycol diacetate, methylene dicarbamate, N- ethyl
Pyrrolidones, dimethyl sulfoxide, and also contain spectrasolv DMDA and N, one of N- dimethyl-octa certain herbaceous plants with big flowers amide or
Two kinds.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, the N- dimethyl last of the ten Heavenly stems
Amide.
In another preferred example, in parts by weight, the organic solvent contains 20-55 parts of propylene-glycol diacetates, 10-30
Part methylene dicarbamate, 1-10 parts of N- ethyl pyrrolidones, 1-10 parts of dimethyl sulfoxides and 20-25 parts of N, N- dimethyl-octa
Certain herbaceous plants with big flowers amide.
In another preferred example, the total content of the propylene-glycol diacetate and methylene dicarbamate is 6-
40wt%, preferably 11.5-26wt%, by the total weight of pesticidal preparations.
In another preference, the content of the propylene-glycol diacetate is 5-30wt%, and preferably 10-20wt% is pressed
The total weight of pesticidal preparations.
In another preferred example, the content of the methylene dicarbamate be 1-10w%, preferably 1.5-6wt%,
By the total weight of pesticidal preparations.
Methylene dicarbamate, appearance: clear solution, 71 DEG C of flash-point, boiling range；168-175 DEG C, purity；>=98%.
Propylene-glycol diacetate, appearance；Clear solution, flash-point: 88 DEG C, boiling range；180-210 DEG C, purity: >=99%.Third
Glycol diacetate contains light mint smell, and Environmental Safety is nonflammable.Propylene-glycol diacetate is soluble in alcohol, ether and other has
Solvent, the general chemical property with ester, flash-point is high, not volatile, and hydrolysis is easy in the presence of caustic alkali and inorganic acid
At pure and mild acetic acid, easily biological-degradable.
Emulsifier
In the present invention, the content of the emulsifier is 5-20wt%, preferably 10-20wt%, by the total of pesticidal preparations
Poidometer.
The emulsifier one of is selected from the group or a variety of (preferably 2,3,4,5 kind): triphenyl vinyl phenol polyoxy
Vinethene, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether, nonionic
Type hydroxyl polyethylene oxide block copolymer.
In another preferred example, the emulsifier contains tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxy
Ethylene polyethenoxy ether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether and non-ionic hydroxyl poly-ethylene oxide block
At least three kinds in copolymer.
In another preferred example, the emulsifier contains tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxy
Ethylene polyethenoxy ether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether and non-ionic hydroxyl poly-ethylene oxide block
Copolymer.
In another preferred example, in parts by weight, the emulsifier contains 2-8 parts of triphenyl vinyl phenol polyoxyethylene
Ether, 2-8 parts of phenethyl phenol polyoxyethylene poly-oxygen propylene aethers, 1-2 parts of fatty alcohol polyoxyethylene ether, 1-2 parts of anacardol polyoxy second
Alkene ether and 1-2 parts of non-ionic hydroxyl polyethylene oxide block copolymers.
Pesticidal preparations
The present invention provides a kind of avermectin pesticides efficiently, less toxic, inexpensive.
As used herein, " avermectin nanometer lotion " " avermectin preparation " " avermectin pesticides " " pesticide of the present invention
Preparation " is used interchangeably, and refers both to pesticidal preparations described in first aspect present invention.
In the present invention, the pesticidal preparations include following components: 0.1-10wt% avermectin, 5-45wt% are organic molten
Agent, 5-20wt% emulsifier, 0.5-3wt% stabilizer and water, wherein the organic solvent includes propylene-glycol diacetate and first
Ylcarbamic acid methyl ester.
Specifically, the present invention provides the preparation methods and application of a kind of avermectin nanometer lotion.
In a preferred embodiment of the invention, the avermectin nanometer lotion includes: avermectin 1.0%
~10.0wt%, solvent 10.0wt%~40.0wt%, vegetable oil 0.1wt%~2.0wt%, stabilizer 0.5%~
2.0wt%, dispersing agent 1.0wt%~3.0wt%, synergist 1.0wt%~5.0wt%, emulsifier 10.0wt%~
20.0wt%, antifreezing agent 3.0wt%~5.0wt%, defoaming agent 0.01wt%~0.05wt%, the water of surplus, by avermectin
The total weight of nano-emulsion.
Wherein, it is preferable that the avermectin content is 5.0wt%.
Wherein, it is preferable that the solvent contains propylene-glycol diacetate and methylene dicarbamate.In addition, described molten
Agent can also contain N- ethyl pyrrolidone, dimethyl sulfoxide, N, in N- dimethyldecamide and N, N- dimethyl-octa certain herbaceous plants with big flowers amide
It is one or more.
Wherein, it is preferable that the solvent be propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone,
Dimethyl sulfoxide and spectrasolv DMDA or propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidine
Ketone, dimethyl sulfoxide and N, the combination of N- dimethyl-octa certain herbaceous plants with big flowers amide.
Wherein, it is preferable that the vegetable oil is cashew nut shell oil.
Wherein, the dispersing agent is phosphoric acid salt anion.
Wherein, it is preferable that the synergist is to have aerosol OT, machine silicon polyoxyethylene ether.
Wherein, it is preferable that the emulsifier is tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene is poly-
Oxypropylene ether, fatty alcohol polyoxyethylene ether, non-ionic hydroxyl polyethylene oxide block copolymer and combinations thereof.
Wherein, it is preferable that the antifreezing agent is glycerine.
Wherein, the defoaming agent is dimethicone.
The sum of each component content is 100% in pesticidal preparations of the invention.It will be understood by those skilled in the art that " each group
The sum of point content further includes above-mentioned other components (such as various routines added according to actual needs for " each component " in 100% "
Auxiliary agent).
In one particular embodiment of the present invention, the preparation method of avermectin nanometer lotion includes the following steps:
S1: weighing avermectin, solvent, vegetable oil and stabilizer, is added in container A, is mixed evenly together；
S2: being added emulsifier, synergist and defoaming agent into the container A again, stir evenly, and forms oily phase；
S3: weighing dispersing agent, antifreezing agent and water, is added in container B, is mixed evenly together, forms water phase；
S4: the water phase is added in the oily phase, high speed shearing emulsification is carried out, the AVM hereinafter of homogeneous phase transparent is made
Rhzomorph nanoemulsions.
Above-mentioned avermectin nanometer lotion is prepared by emulsification oil process or emulsified water method, the partial size of nanoparticle in nanoemulsions
Preferably 15-25nm.Thus it is preferably dispersed to assign avermectin nanometer lotion, is easy to penetrate into target body, be conducive to
The infiltration of drug effect and enhancing to harmful organisms or plant surface is played, therefore contact efficacy can be improved or prevent and treat concealed
Pest, harmful mite and nematode.
Technical solution of the present invention has the following beneficial effects:
1. pesticidal preparations preparation process of the present invention is simple, favorable reproducibility, at low cost, it can be achieved that industrial production；
2. pesticidal preparations of the present invention do not have penetrating odor, and ageing stability is good；
3. comparing existing level, pesticidal preparations of the present invention are more preferable to pest repelling and fragmentation effect, the lasting period significantly extends,
Quick-acting is good；
4. the solvent that pesticidal preparations of the present invention are selected is environmentally friendly solvent, easily biological-degradable, environmentally protective, safety, toxicity are low；
5. pesticidal preparations of the present invention are with water dispersion medium, to the producer and user, the safety is improved.
Below with reference to specific implementation, the present invention is further explained.It should be understood that these embodiments be merely to illustrate the present invention and
It is not used in and limits the scope of the invention.In the following examples, the experimental methods for specific conditions are not specified, usually according to normal condition,
Such as Sambrook et al., molecular cloning: laboratory manual (New York:Cold Spring Harbor Laboratory
Press, 1989) condition described in, or according to the normal condition proposed by manufacturer.Unless otherwise stated, otherwise percentage and
Number is calculated by weight.
Embodiment 1
The avermectin nanometer lotion of the present embodiment is equipped with solvent, vegetable oil, stabilization using avermectin as effective component
Agent, dispersing agent, emulsifier, synergist, antifreezing agent, defoaming agent, water form avermectin nanometer lotion.Contain by mass percentage
Have:
Avermectin: 5%
Solvent: 25%
Vegetable oil: 1%；
Light stabilizer: 1.5%；
Emulsifier: 15%
Synergist: 3%；
Dispersing agent: 2%；
Antifreezing agent: 5%；
Defoaming agent: 0.01%；
Soft water: 42.49%
Wherein, solvent is propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide
With the combination of spectrasolv DMDA, wherein propylene-glycol diacetate 10.5%, methylene dicarbamate 1.5%, N- second
Base pyrrolidones 1.5%, dimethyl sulfoxide 1.5%, N, N- dimethyl certain herbaceous plants with big flowers amide 10%, with lotion total weight；Vegetable oil is
Cashew nut shell oil；Light stabilizer is BHT；Emulsifier is tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene is poly-
Oxypropylene ether, the combination of non-ionic hydroxyl polyethylene oxide block copolymer；Synergist is organosilicone polyoxyethylene ether；Dispersing agent
For phosphoric acid salt anion；Antifreezing agent is glycerine, and defoaming agent is dimethicone.
The preparation method of the avermectin nanometer cream of the present embodiment: 5g the former medicine of AVM, 30g propylene glycol are weighed in proportion
The mixing of diacetate esters, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide and N, N- dimethyldecamide
Object, 1g cashew nut shell oil, 1.5gBHT, 3g organosilicone polyoxyethylene ether stir to clarify transparent, addition 15g triphenyl vinyl phenol
Polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, the mixing of non-ionic hydroxyl polyethylene oxide block copolymer
Object, 0.01g dimethicone, stirring form oily phase.2g dispersing agent, 5g antifreezing agent, 42.49g water is weighed in proportion to be mixed
Afterwards, water phase is formed.Oily phase is added in water phase under high speed shear effect, forms 5% avermectin nanometer lotion.
Embodiment 2
The avermectin nanometer lotion of the present embodiment is equipped with solvent, vegetable oil, stabilization using avermectin as effective component
Agent, dispersing agent, emulsifier, synergist, antifreezing agent, defoaming agent, water form avermectin nanometer lotion.Contain by mass percentage
Have:
Avermectin B2: 5%
Solvent: 25%；
Vegetable oil: 1%；
Stabilizer: 1.5%
Emulsifier: 15%；
Synergist: 3%
Dispersing agent: 2%；
Antifreezing agent: 5%；
Defoaming agent: 0.01%；
Soft water: 42.49%
Wherein, solvent is propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide
And combination propylene-glycol diacetate 10.5%, methylene dicarbamate 1.5%, the N- N-ethyl pyrrole N of N, N- dimethyldecamide
Alkanone 1.5%, dimethyl sulfoxide 1.5%, N, N- dimethyl-octa certain herbaceous plants with big flowers amide 10%, with lotion total weight；Vegetable oil is cashew nut
Shell oil；Stabilizer is BHT；Emulsifier is tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene
Ether, cardanol polyoxyethylene ether combination；Synergist is aerosol OT；Dispersing agent is phosphoric acid salt anion；It is anti-
Jelly agent is glycerine, and defoaming agent is dimethicone.
The preparation method of the avermectin nanometer cream of the present embodiment: 5g the former medicine of AVM, 25g propylene glycol are weighed in proportion
The mixing of diacetate esters, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide and N, N- dimethyldecamide
Object, 1g cashew nut shell oil, 1.5gBHT, 3g aerosol OT stir to clarify transparent, addition 15g triphenylethylene base benzene
Phenol polyethenoxy ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, cardanol polyoxyethylene ether mixture, 0.01g dimethyl
Silicone oil, stirring form oily phase.After weighing 2g dispersing agent, 5g antifreezing agent, the mixing of 42.49g water in proportion, water phase is formed.?
Oily phase is added in water phase under high speed shear effect, forms 5% Avermectin B2 nanoemulsions.
Embodiment 3
The avermectin nanometer lotion of the present embodiment is equipped with solvent, vegetable oil, stabilization using avermectin as effective component
Agent, dispersing agent, emulsifier, synergist, antifreezing agent, defoaming agent, water form avermectin nanometer lotion.Contain by mass percentage
Have:
Avermectin: 10%
Solvent: 37.5%
Vegetable oil: 0.5%；
Light stabilizer: 3%
Emulsifier: 20%；
Synergist: 1.5%；
Dispersing agent: 2%；
Antifreezing agent: 5%；
Defoaming agent: 0.02%；
Soft water: 20.48%
Wherein, solvent is propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide
And combination propylene-glycol diacetate 19.5%, methylene dicarbamate 5%, the N- N-ethyl pyrrole N of N, N- dimethyl-octa decyl amide
Alkanone 1.5%, dimethyl sulfoxide 1.5%, N, N- dimethyl certain herbaceous plants with big flowers amide 10%, with lotion total weight；Vegetable oil is cashew nut shell
Oil；Stabilizer is BHT；Emulsifier be tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether,
Fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether, non-ionic hydroxyl polyethylene oxide block copolymer mixture；Synergy
Agent is organosilicone polyoxyethylene ether；Dispersing agent is phosphoric acid salt anion；Antifreezing agent is glycerine, and defoaming agent is dimethyl-silicon
Oil.
The preparation method of the avermectin nanometer cream of the present embodiment: 10g the former medicine of AVM, 37.5g are weighed in proportion
Propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide and N, N- dimethyldecamide
Mixture, 0.5g cashew nut shell oil, 3gBHT, 1.5g organosilicone polyoxyethylene ether stir to clarify transparent, addition 20g triphenylethylene
Base phenol polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether, cashew nut phenol polyethenoxy
Ether, non-ionic hydroxyl polyethylene oxide block copolymer mixture, 0.02g dimethicone, stirring form oily phase.In proportion
After weighing 2g dispersing agent, 5g antifreezing agent, the mixing of 20.48g water, water phase is formed.Water phase is added under high speed shear effect
Oily phase forms 10% avermectin nanometer lotion.
Embodiment 4
The avermectin nanometer lotion of the present embodiment is equipped with solvent, vegetable oil, stabilization using avermectin as effective component
Agent, dispersing agent, emulsifier, synergist, antifreezing agent, defoaming agent, water form avermectin nanometer lotion.Contain by mass percentage
Have:
Avermectin B2: 10%
Solvent: 37.5%
Vegetable oil: 0.5%；
Light stabilizer: 3%
Emulsifier: 20%；
Synergist: 1.5%；
Dispersing agent: 2%；
Antifreezing agent: 5%；
Defoaming agent: 0.02%；
Soft water: 20.48%
Wherein, solvent is propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide
And combination propylene-glycol diacetate 19.5%, methylene dicarbamate 5%, the N- N-ethyl pyrrole N of N, N- dimethyl-octa decyl amide
Alkanone 1.5%, dimethyl sulfoxide 1.5%, N, N- dimethyl-octa certain herbaceous plants with big flowers amide 10%, with lotion total weight；Vegetable oil is cashew nut
Shell oil；Light stabilizer is triethyl citrate；Emulsifier is tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxy second
Alkene polyethenoxy ether, fatty alcohol polyoxyethylene ether, cardanol polyoxyethylene ether, the copolymerization of non-ionic hydroxyl poly-ethylene oxide block
Object mixture；Synergist is aerosol OT；Dispersing agent is phosphoric acid salt anion；Antifreezing agent is glycerine, is disappeared
Infusion is dimethicone.
The preparation method of the avermectin nanometer cream of the present embodiment: 10g the former medicine of AVM, 37.5g are weighed in proportion
Propylene-glycol diacetate, methylene dicarbamate, N- ethyl pyrrolidone, dimethyl sulfoxide and N, N- dimethyl-octa decyl amide
Mixture, 0.5g cashew nut shell oil, 3gBHT, 1.5g aerosol OT stir to clarify transparent, 20g triphen is added
Vinyl benzene phenol polyethenoxy ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether, anacardol polyoxy
Vinethene, non-ionic hydroxyl polyethylene oxide block copolymer mixture, 0.02g dimethicone, stirring form oily phase.It presses
After ratio weighs 2g dispersing agent, 5g antifreezing agent, the mixing of 20.48g water, water phase is formed.By water phase under high speed shear effect
Oily phase is added, forms 10% Avermectin B2 nanoemulsions.
Embodiment 5
The avermectin nanometer lotion of the present embodiment is equipped with solvent, vegetable oil, stabilization using avermectin as effective component
Agent, dispersing agent, emulsifier, synergist, antifreezing agent, defoaming agent, water form avermectin nanometer lotion.Contain by mass percentage
Have:
Avermectin: 5%
Solvent: 30%
Vegetable oil: 0.5%；
Light stabilizer: 1.5%
Emulsifier: 15%；
Synergist: 3%；
Dispersing agent: 2%；
Antifreezing agent: 5%；
Defoaming agent: 0.01%；
Soft water: 37.99%
Wherein, solvent is the combination of propylene-glycol diacetate, methylene dicarbamate: propylene-glycol diacetate
22.5%, methylene dicarbamate 7.5%, with lotion total weight；Vegetable oil is cashew nut shell oil；Light stabilizer is BHT；Cream
Agent be tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether,
Cardanol polyoxyethylene ether, non-ionic hydroxyl polyethylene oxide block copolymer mixture；Synergist is organosilicon polyoxy second
Alkene ether；Dispersing agent is phosphoric acid salt anion；Antifreezing agent is glycerine, and defoaming agent is dimethicone.
The preparation method of the avermectin nanometer cream of the present embodiment: 10g the former medicine of AVM, 22.5g third are weighed in proportion
Glycol diacetate, 7.5g methylene dicarbamate, 0.5g cashew nut shell oil, the stirring of 1.5gBHT, 3g organosilicone polyoxyethylene ether
To clear, 20g tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fat is added
Alcohol polyoxyethylene ether, cardanol polyoxyethylene ether, non-ionic hydroxyl polyethylene oxide block copolymer mixture, 0.01g bis-
Methyl-silicone oil, stirring form oily phase.After weighing 2g dispersing agent, 5g antifreezing agent, the mixing of 37.99g water in proportion, water is formed
Phase.Oily phase is added in water phase under high speed shear effect, forms 5% avermectin nanometer lotion.
The avermectin nanometer lotion prepared in above-described embodiment is carried out drug effect to wild cabbage plutella xylostella in field by embodiment 6
Test, with 5% abamectin emulsifiable concentrate (commercially available) and 10% avermectin suspending agent (commercially available), 10% avermectin water dispersible granular
(commercially available) agent is comparison medicament, and experimental result is shown in Table 1.
Field control effectiveness test method is according to GB/T 17980.13-2000 field control effectiveness test criterion (one) insecticide control
The lepidopterous larvae of brassicaceous vegetable
1 avermectin nanometer cream of table prevents and treats wild cabbage plutella xylostella field efficacy
Table 1 the experimental results showed that, avermectin nanometer lotion is above the control efficiency of wild cabbage plutella xylostella in 1-3 days
88%, it is better than comparison medicament.In terms of holding effect sex expression, the preventive effect of avermectin nanometer lotion after 28 days can reach 71% with
On, 42 days control efficiency are also higher than 62%, are completely superior to comparison medicament, show that the sustained release performance of said preparation is excellent.
The avermectin nanometer lotion prepared in above-described embodiment is carried out drug effect to cotton red spider in field by embodiment 7
Test, with 5% abamectin emulsifiable concentrate (commercially available) and 10% avermectin suspending agent (commercially available), 10% avermectin water dispersible granular
(commercially available) agent is comparison medicament, and experimental result is shown in Table 2.
Field control effectiveness test method is according to GB/T 17980.74-2000 field control effectiveness test criterion (two) insecticide control
Cotton red spider
2 avermectin nanometer cream of table prevents and treats cotton red spider field efficacy
Table 2 the experimental results showed that, avermectin nanometer lotion is above the control efficiency of cotton red spider in 1-3 days
91%, it is better than comparison medicament.In terms of holding effect sex expression, the preventive effect of avermectin nanometer lotion after 28 days can reach 75% with
On, 42 days control efficiency are also higher than 64%, are completely superior to comparison medicament, show that said preparation prevents also cotton red spider
With preferable effect.
Embodiment 8
The avermectin nanometer lotion prepared in above-described embodiment is subjected to pharmacodynamic test to citrus red mite in field, with
5% abamectin emulsifiable concentrate (commercially available) and 10% avermectin suspending agent (commercially available), 10% water dispersion particle agent of abamectin (city
Sell) it is comparison medicament, experimental result is shown in Table 3.
Field control effectiveness test method is anti-according to GB/T 17980.38-2000 field control effectiveness test criterion (one) nematicide
Control root nematodiasis
3 avermectin nanometer cream of table prevents and treats cucumber root-knot nematode field efficacy
Table 3 the experimental results showed that, the avermectin nanometer lotion of embodiment 2 and embodiment 4,1-3 days to cucumber root knot
The control efficiency of nematode is above 89%, is better than comparison medicament.In terms of holding effect sex expression, avermectin nanometer cream is after 28 days
Preventive effect can reach 77% or more, 42 days control efficiency are also higher than 66%, are completely superior to comparison medicament, show said preparation pair
Cucumber root-knot nematode prevents also with preferable effect.
All references mentioned in the present invention is incorporated herein by reference, independent just as each document
It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can
To make various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims
It encloses.
Claims (10)
1. a kind of pesticidal preparations, which is characterized in that with pesticidal preparations total weight, the pesticidal preparations include following components:
0.1-10wt% avermectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% stabilizer and water, wherein institute
Stating organic solvent includes propylene-glycol diacetate and methylene dicarbamate.
2. pesticidal preparations as described in claim 1, which is characterized in that the propylene-glycol diacetate and methyl carbamic acid first
The total content of ester is at least 25wt%, preferably 40-80wt%, more preferably 50-65wt%, by the total weight of organic solvent.
3. pesticidal preparations as described in claim 1, which is characterized in that the propylene-glycol diacetate and methyl carbamic acid first
The weight ratio of ester is 10:1-1:1, preferably 8:1-2:1.
4. pesticidal preparations as described in claim 1, which is characterized in that the organic solvent, which also contains, one of to be selected from the group
It is or a variety of: N- ethyl pyrrolidone, dimethyl sulfoxide, N, N- dimethyldecamide, N, N- dimethyl-octa certain herbaceous plants with big flowers amide.
5. pesticidal preparations as described in claim 1, which is characterized in that the emulsifier one of is selected from the group or a variety of:
Tristyrylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, fatty alcohol polyoxyethylene ether, anacardol
Polyoxyethylene ether, non-ionic hydroxyl polyethylene oxide block copolymer.
6. pesticidal preparations as described in claim 1, which is characterized in that the total weight based on pesticidal preparations, the pesticidal preparations
Include following components:
Avermectin 1-10wt%, organic solvent 10-40wt%, emulsifier 10-20wt%, stabilizer 0.5-3wt%, vegetable oil
0.1-2wt%, synergist 1-5wt%, dispersing agent 1-3wt%, antifreezing agent 3-5wt%, defoaming agent 0.01-0.05wt% and water.
7. application of the pesticidal preparations described in claim 1 in prevention and treatment harmful organism.
8. a kind of preparation method of pesticidal preparations, which is characterized in that the method includes the steps:
(a) by 0.01-10wt% avermectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% stabilizer,
Water and the mixing of optional auxiliary agent obtain wherein the organic solvent includes propylene-glycol diacetate and methylene dicarbamate
To mixture；With
(b) mixture in step (a) is emulsified, obtains the pesticidal preparations.
9. a kind of organic solvent, which is characterized in that with organic solvent total weight, the organic solvent contains:
(a) 30-80 parts, preferably 40-60 parts of propylene-glycol diacetate；
(b) 6-20 parts, preferably 10-15 parts of methylene dicarbamate；And optional
(c) N- ethyl pyrrolidone, dimethyl sulfoxide, N, one of N- dimethyldecamide and N, N- dimethyl-octa certain herbaceous plants with big flowers amide
Or it is a variety of.
10. the purposes of organic solvent as claimed in claim 9, which is characterized in that be used to prepare pesticidal preparations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811573725.4A CN109452269B (en) | 2018-12-21 | 2018-12-21 | Abamectin emulsion preparation and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811573725.4A CN109452269B (en) | 2018-12-21 | 2018-12-21 | Abamectin emulsion preparation and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109452269A true CN109452269A (en) | 2019-03-12 |
| CN109452269B CN109452269B (en) | 2021-06-01 |
Family
ID=65614261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811573725.4A Active CN109452269B (en) | 2018-12-21 | 2018-12-21 | Abamectin emulsion preparation and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109452269B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931143A (en) * | 2022-06-20 | 2022-08-23 | 硅羿科技（上海）有限公司 | Pesticide preparation for killing panonychus citri and preparation method and application thereof |
Citations (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307802A (en) * | 2000-12-29 | 2001-08-15 | 唐睿 | Serial abamectin pesticide micro emulsion and its production process |
| CN1586199A (en) * | 2004-07-19 | 2005-03-02 | 马韵升 | High concentration abamectin pest killing micro emulsion |
| US20060078585A1 (en) * | 2004-10-08 | 2006-04-13 | Wyeth | Amitraz compositions |
| CN1775026A (en) * | 2005-11-21 | 2006-05-24 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN101002559A (en) * | 2006-01-17 | 2007-07-25 | 上海农乐生物制品股份有限公司 | Aqueous emulsion containing abamectin, and its preparing method |
| CN101035432A (en) * | 2004-10-08 | 2007-09-12 | 辛根塔参与股份公司 | Fungicidal compositions |
| CN101112195A (en) * | 2007-08-22 | 2008-01-30 | 武汉大学 | Avermectin micro-emulsion and method for preparing the same |
| CN101422155A (en) * | 2007-10-29 | 2009-05-06 | 山东京博控股发展有限公司 | Insecticide and miticide composition |
| CN101502266A (en) * | 2009-03-27 | 2009-08-12 | 郭正 | Liquid pesticide formulation containing avermectin pesticide and organosilicon surfactant and preparation method thereof |
| CN101530075A (en) * | 2008-03-14 | 2009-09-16 | 北京绿色农华植保科技有限责任公司 | Abamectin hexythiazox micro-emulsion and preparation method thereof |
| CN101564036A (en) * | 2009-04-08 | 2009-10-28 | 陶钧炳 | Abamectin-containing aqueous emulsion |
| CN101589717A (en) * | 2009-07-02 | 2009-12-02 | 江苏省农业科学院 | The sustained-release synergistic avermectin microemulsion that is used for paddy rice |
| CN101669491A (en) * | 2009-09-25 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Pesticide emulsion and preparation method thereof |
| CN102783481A (en) * | 2012-08-02 | 2012-11-21 | 天津市汇源化学品有限公司 | Preparation method of abamectin water emulsion |
| CN102885059A (en) * | 2012-09-28 | 2013-01-23 | 王龙华 | Avermectin emulsion pesticide and production technology thereof |
| CN102885060A (en) * | 2012-09-29 | 2013-01-23 | 华南农业大学 | Avermectin nanometer microemulsion and preparation method thereof |
| CN103518713A (en) * | 2013-10-12 | 2014-01-22 | 天津市华宇农药有限公司 | Synergist used in 5% avermectin emulsion in water |
| WO2014128564A2 (en) * | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| CN104273142A (en) * | 2014-10-15 | 2015-01-14 | 济南新起点医药科技有限公司 | Abamectin-containing emulsion in water and application |
| CN104304244A (en) * | 2014-09-11 | 2015-01-28 | 广西田园生化股份有限公司 | Uvioresistant absorber used for pesticide preparation |
| CN104738031A (en) * | 2013-12-31 | 2015-07-01 | 汕头市深泰新材料科技发展有限公司 | Abamectin emulsion in water and preparation method thereof |
| CN106614548A (en) * | 2016-12-28 | 2017-05-10 | 王敏 | Vegetable oil compounded synergistic microemulsion type acaricidal agent and preparation method thereof |
| CN107027746A (en) * | 2017-04-10 | 2017-08-11 | 华南理工大学 | A kind of slow-release pesticide microemulsion and preparation method thereof |
| CN107156115A (en) * | 2017-07-14 | 2017-09-15 | 安徽海日生物科技有限公司 | A kind of HEXAFLUMURON and emamectin-benzoate complex microemulsion and preparation method thereof |
| WO2017180587A2 (en) * | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN107306975A (en) * | 2017-05-26 | 2017-11-03 | 河北威远生物化工有限公司 | A kind of avermectin B2a synergy microemulsion and preparation method thereof |
| CN108029683A (en) * | 2017-10-26 | 2018-05-15 | 江苏腾龙生物药业有限公司 | A kind of aqueous emulsion and its preparation process containing phenthoate dimephenthoate cidial and avermectin |
-
2018
- 2018-12-21 CN CN201811573725.4A patent/CN109452269B/en active Active
Patent Citations (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307802A (en) * | 2000-12-29 | 2001-08-15 | 唐睿 | Serial abamectin pesticide micro emulsion and its production process |
| CN1586199A (en) * | 2004-07-19 | 2005-03-02 | 马韵升 | High concentration abamectin pest killing micro emulsion |
| US20060078585A1 (en) * | 2004-10-08 | 2006-04-13 | Wyeth | Amitraz compositions |
| CN101035432A (en) * | 2004-10-08 | 2007-09-12 | 辛根塔参与股份公司 | Fungicidal compositions |
| CN1775026A (en) * | 2005-11-21 | 2006-05-24 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN101002559A (en) * | 2006-01-17 | 2007-07-25 | 上海农乐生物制品股份有限公司 | Aqueous emulsion containing abamectin, and its preparing method |
| CN101112195A (en) * | 2007-08-22 | 2008-01-30 | 武汉大学 | Avermectin micro-emulsion and method for preparing the same |
| CN101422155A (en) * | 2007-10-29 | 2009-05-06 | 山东京博控股发展有限公司 | Insecticide and miticide composition |
| CN101530075A (en) * | 2008-03-14 | 2009-09-16 | 北京绿色农华植保科技有限责任公司 | Abamectin hexythiazox micro-emulsion and preparation method thereof |
| CN101502266A (en) * | 2009-03-27 | 2009-08-12 | 郭正 | Liquid pesticide formulation containing avermectin pesticide and organosilicon surfactant and preparation method thereof |
| CN101564036A (en) * | 2009-04-08 | 2009-10-28 | 陶钧炳 | Abamectin-containing aqueous emulsion |
| CN101589717A (en) * | 2009-07-02 | 2009-12-02 | 江苏省农业科学院 | The sustained-release synergistic avermectin microemulsion that is used for paddy rice |
| CN101669491A (en) * | 2009-09-25 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Pesticide emulsion and preparation method thereof |
| CN102783481A (en) * | 2012-08-02 | 2012-11-21 | 天津市汇源化学品有限公司 | Preparation method of abamectin water emulsion |
| CN102885059A (en) * | 2012-09-28 | 2013-01-23 | 王龙华 | Avermectin emulsion pesticide and production technology thereof |
| CN102885060A (en) * | 2012-09-29 | 2013-01-23 | 华南农业大学 | Avermectin nanometer microemulsion and preparation method thereof |
| WO2014128564A2 (en) * | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| CN103518713A (en) * | 2013-10-12 | 2014-01-22 | 天津市华宇农药有限公司 | Synergist used in 5% avermectin emulsion in water |
| CN104738031A (en) * | 2013-12-31 | 2015-07-01 | 汕头市深泰新材料科技发展有限公司 | Abamectin emulsion in water and preparation method thereof |
| CN104304244A (en) * | 2014-09-11 | 2015-01-28 | 广西田园生化股份有限公司 | Uvioresistant absorber used for pesticide preparation |
| CN104273142A (en) * | 2014-10-15 | 2015-01-14 | 济南新起点医药科技有限公司 | Abamectin-containing emulsion in water and application |
| WO2017180587A2 (en) * | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN106614548A (en) * | 2016-12-28 | 2017-05-10 | 王敏 | Vegetable oil compounded synergistic microemulsion type acaricidal agent and preparation method thereof |
| CN107027746A (en) * | 2017-04-10 | 2017-08-11 | 华南理工大学 | A kind of slow-release pesticide microemulsion and preparation method thereof |
| CN107306975A (en) * | 2017-05-26 | 2017-11-03 | 河北威远生物化工有限公司 | A kind of avermectin B2a synergy microemulsion and preparation method thereof |
| CN107156115A (en) * | 2017-07-14 | 2017-09-15 | 安徽海日生物科技有限公司 | A kind of HEXAFLUMURON and emamectin-benzoate complex microemulsion and preparation method thereof |
| CN108029683A (en) * | 2017-10-26 | 2018-05-15 | 江苏腾龙生物药业有限公司 | A kind of aqueous emulsion and its preparation process containing phenthoate dimephenthoate cidial and avermectin |
Non-Patent Citations (12)
| Title |
|---|
| GREAVES A J ET AL: "Abamectin to control armoured scales (Hemiptera: Diaspididae) on kiwifruit", 《NEW ZEALAND JOURNAL OF EXPERIMENTAL AGRICULTURE》 * |
| HOY M A ET AL.: "Selection of the Western Predatory Mite, Metaseiulus occidentalis (Acari: Phytoseiidae), for Resistance to Abamectin", 《JOURNAL OF ECONOMIC ENTOMOLOGY》 * |
| SLAVICA GAŠIĆ ET AL: "Oil Dispersion with Abamectin as Active Ingredient", 《PESTICIDI I FITOMEDICINA》 * |
| WANG A ET AL: "Fabrication, characterization, and biological activity of avermectin nano-delivery systems with different particle sizes", 《NANOSCALE RES LETT》 * |
| 张宏浩等: "2%阿维菌素水乳剂的研制", 《热带农业工程》 * |
| 曾令玲等: "0.9%阿维菌素乳油防治柑桔红蜘蛛田间药效试验", 《现代农业科技》 * |
| 曾益良等: "氨基甲酸酯类杀虫剂与阿维菌素混配防治甜菜夜蛾", 《植物保护》 * |
| 李戎: "乙螨唑水分散粒剂和阿维菌素微乳剂防治柑桔全爪螨药效试验", 《中国南方果树》 * |
| 梁孝生: "5%阿维菌素微乳剂的研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》 * |
| 汪保记: "阿维菌素不同剂型及浓度对梨木虱防效试验", 《安徽农学通报》 * |
| 韩鹏杰等: "7种水基化杀虫剂对露地甘蓝小菜蛾的防治效果", 《山西农业科学》 * |
| 马立功: "几种杀虫剂对十字花科蔬菜小菜蛾的药效试验", 《北方园艺》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931143A (en) * | 2022-06-20 | 2022-08-23 | 硅羿科技（上海）有限公司 | Pesticide preparation for killing panonychus citri and preparation method and application thereof |
| CN114931143B (en) * | 2022-06-20 | 2024-03-08 | 硅羿科技（上海）有限公司 | Pesticide preparation for killing panonychus citri, and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109452269B (en) | 2021-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lucia et al. | Emulsions containing essential oils, their components or volatile semiochemicals as promising tools for insect pest and pathogen management | |
| KR101780834B1 (en) | Anthraquinone containing derivatives as biochemical agricultural products | |
| CN102057897B (en) | Chlorpyrifos microcapsule suspension and preparation method thereof | |
| ITBO20130530A1 (en) | PESTICIDE BASED ON NATURAL EXTRACTS | |
| CN105557747A (en) | Stable pesticide microcapsule suspending agent | |
| Sánchez-Gómez et al. | Lethal and sublethal effects of essential oil-loaded zein nanocapsules on a zoonotic disease vector mosquito, and their non-target impact | |
| CN110476963A (en) | A kind of tank-mix adjuvants and its preparation method and application | |
| CN111165481A (en) | Diatomite-avermectin pesticide composition with specific structure and application thereof | |
| JP6832275B2 (en) | Limonene: formulation and pesticide use | |
| CN101406185A (en) | Compositional agent for killing insects and mites with synergistic interaction containing spirodiclofen | |
| CN101485338B (en) | Green food pesticide composition and uses thereof | |
| CN109452269A (en) | Avermectin emulsion formulations and preparation method and application | |
| CN101554159A (en) | Fenpropathrin microemulsion and preparation method thereof | |
| CN102511477B (en) | Pyrethrin hot fogging agent and preparation method and application thereof | |
| CN110537555A (en) | Preparation of mosquito repellent liquid with bactericidal effect based on natural plant extract | |
| CN102696641A (en) | Molluscicide for Pomacea canaliculata and production method for molluscicide | |
| WO2020160536A1 (en) | Methods for controlling black sigatoka in bananas using pongamia oil and formulations thereof | |
| CN103070191B (en) | Pesticide composition containing phoxim and azadirachtin | |
| CN102246827A (en) | Compound pesticide | |
| CN104542729A (en) | Azadirachtin-containing botanical insect aerosol and preparation method thereof | |
| CN108782615A (en) | One kind killing thrips plant essential oil composition, preparation and its application | |
| US20130059909A1 (en) | Cinnamaldehyde-Allicin Formulations and Methods of Their Use | |
| US20120156316A1 (en) | Biocompatible tea tree oil compositions | |
| EP2477489A1 (en) | Synergistic combination and composition for use as acaricide, insecticide, pupicide and/or larvicide | |
| CN108402061B (en) | Biopesticide composition for preventing and treating tea geometrid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |