CN101564036A - Abamectin-containing aqueous emulsion - Google Patents
Abamectin-containing aqueous emulsion Download PDFInfo
- Publication number
- CN101564036A CN101564036A CNA2009100973132A CN200910097313A CN101564036A CN 101564036 A CN101564036 A CN 101564036A CN A2009100973132 A CNA2009100973132 A CN A2009100973132A CN 200910097313 A CN200910097313 A CN 200910097313A CN 101564036 A CN101564036 A CN 101564036A
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- CN
- China
- Prior art keywords
- aqueous emulsion
- avermectin
- oil
- ether
- abamectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005660 Abamectin Substances 0.000 title claims abstract description 67
- 239000000839 emulsion Substances 0.000 title claims abstract description 51
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract description 26
- 229950008167 Abamectin Drugs 0.000 title abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- LNJXZKBHJZAIKQ-UHFFFAOYSA-N 1,1,1,2-tetrachloro-3-(2,3,3,3-tetrachloropropoxy)propane Chemical compound ClC(Cl)(Cl)C(Cl)COCC(Cl)C(Cl)(Cl)Cl LNJXZKBHJZAIKQ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 231100000053 low toxicity Toxicity 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 239000003921 oil Substances 0.000 claims description 30
- 235000019198 oils Nutrition 0.000 claims description 30
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 24
- 241000196324 Embryophyta Species 0.000 claims description 15
- -1 polyoxy ethene Polymers 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
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- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 5
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- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 4
- 241001044369 Amphion Species 0.000 claims description 4
- 241000195493 Cryptophyta Species 0.000 claims description 4
- 229940067606 Lecithin Drugs 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000008158 vegetable oil Substances 0.000 claims description 4
- KWKXNDCHNDYVRT-UHFFFAOYSA-N Dodecylbenzene Chemical compound CCCCCCCCCCCCC1=CC=CC=C1 KWKXNDCHNDYVRT-UHFFFAOYSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
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- 239000002904 solvent Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- OMFRMAHOUUJSGP-IRHGGOMRSA-N κ-bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 claims description 3
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Hexanone Chemical compound CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 claims description 2
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 claims description 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N Benzophenone Chemical group C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 2
- 210000000481 Breast Anatomy 0.000 claims description 2
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- 229910001051 Magnalium Inorganic materials 0.000 claims description 2
- 229940099511 POLYSORBATE 65 Drugs 0.000 claims description 2
- 229920002642 Polysorbate 65 Polymers 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 2
- NWGKJDSIEKMTRX-HSACVWGTSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (E)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-HSACVWGTSA-N 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000003337 fertilizer Substances 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- AHAREKHAZNPPMI-UHFFFAOYSA-N hexa-1,3-diene Chemical compound CCC=CC=C AHAREKHAZNPPMI-UHFFFAOYSA-N 0.000 claims description 2
- 239000010720 hydraulic oil Substances 0.000 claims description 2
- 150000002430 hydrocarbons Chemical class 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L na2so4 Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- 238000005457 optimization Methods 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 239000005648 plant growth regulator Substances 0.000 claims description 2
- 230000037039 plant physiology Effects 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 claims description 2
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 239000011850 water-based material Substances 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
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- AMFGTOFWMRQMEM-UHFFFAOYSA-N Triazofos Chemical compound N1=C(OP(=S)(OCC)OCC)N=CN1C1=CC=CC=C1 AMFGTOFWMRQMEM-UHFFFAOYSA-N 0.000 description 5
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- 210000002784 Stomach Anatomy 0.000 description 2
- 241001468227 Streptomyces avermitilis Species 0.000 description 2
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
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- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
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- 230000001804 emulsifying Effects 0.000 description 2
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- FEKGWIHDBVDVSM-UHFFFAOYSA-N 1,1,1,2-tetrachloropropane Chemical compound CC(Cl)C(Cl)(Cl)Cl FEKGWIHDBVDVSM-UHFFFAOYSA-N 0.000 description 1
- AZSNMRSAGSSBNP-XPNPUAGNSA-N 22,23-dihydroavermectin B1a Chemical compound C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 AZSNMRSAGSSBNP-XPNPUAGNSA-N 0.000 description 1
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- JHIVVAPYMSGYDF-UHFFFAOYSA-N Cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention relates to an abamectin-containing aqueous emulsion. In order to reduce the use amount of aromatics organic solvents as much as possible, protect users and other beneficial organisms, an abamectin emulsion which has a plurality of functions such as being suitable for plant physiological characteristics, having low toxicity, no incitation or little incitation to people and animals, being not harmful to crops and friendly to environment, preventing insects, treating disease and optimizing quality is provided. The aqueous emulsion consists of abamectin, octachlorodipropyl ether, refined oil, film forming base materials, a plurality of emulgators, plant nutritions, a defoaming agent, a stabilizing agent, an antifreezing agent, and deionized water. The aqueous emulsion is characterized by scientific formulation, advanced process, stability and low toxicity, and broad spectrum and high efficiency.
Description
Technical field
The present invention relates to abamectin pest killing, miticide.The manufacturing process and the method that belong to agricultural chemicals.
Background technology
Avermectin, English name Avermectins, be to have desinsection, kill ten hexa-atomic Macrocyclic lactone compounds of mite, eelworm-killing activity, produce by streptomyces griseus Streptomyces avermitilis fermentation in the streptomycete by university's big village intelligence in the Japanese north etc. and the class that U.S. Merck company at first develops.Contain 8 components among the natural A vermectins, mainly containing 4 kinds is A1a, A2a, B1a and B2a, its total content 〉=80%; 4 corresponding less homologues of ratio are A1b, A2b, B1b and B2b, its total content≤20%.The separation screening from the soil of Jieyang, Guangdong that China is developed by the Shanghai Pesticide Research Institute late 1980s obtains 7051 bacterial strains, and is after this bacterial strain of assay certificate is similar to S.avermitilis Ma-8460, identical with the chemical constitution of avermectin.New Tech. Development General Co., Beijing Agriculture Univ.'s project verification research in 1993 is also produced this medicine of exploitation.Avermectin is a kind of new antibiotic class, has novel structure, the dual-purpose characteristics of farming animals.Along with the raising of people's living standard and to the call of pollution-free food, biopesticide gains great popularity in current agricultural chemicals market, and the authoritative sources predicts that 21 century will be the century of biopesticide.It is reported that European biopesticide will rise to 2004 1.69 hundred million dollars from 100,000,000 dollars sales volumes in 1997.Avermectins is the new product of most popular and tool keen competition in the current biopesticide market.Present commercially available Avermectin agricultural chemicals is to be main insecticidal constituent (Avermectin B1a+B1b, wherein B1a is not less than 90%, B1b is no more than 5%) with abamectin, demarcates with the content of B1a.Since the harmful utmost point in 1991 goes out after (abamectin) enter China agricultural chemicals market, the Avermectis agricultural chemicals occupies than critical role in the control of insect system of China.Avermectins China have 10 at present surplus enterprise of family produce, there are 11 families in the enterprise of enterprise that has obtained the formal registration of agricultural chemicals.
The main formulation of Avermectin is a missible oil at present, and missible oil uses organic solvents such as a large amount of toluene, dimethylbenzene, and these preparations can evaporate in the pesticide application process in the air, and environment is had contamination; Association was appealing always that domestic agricultural chemicals enterprise developed the good novel form of some Environmental compatibilities in recent years, progressively eliminated existing emulsifiable concentrate pesticide product.
A lot of research and reports about abamectin aqueous emulsion and microemulsion are also arranged both at home and abroad.But existing abamectin aqueous emulsion and microemulsion exist problems such as poor stability, function singleness.The incompatibility modern technologies require and environmental protection requirement, and it is transformed exploitation is the main path of developing the Avermectin novel form at present.
Summary of the invention
At the problems referred to above; the present invention is in order to reduce the usage amount of aromatics organic solvent as far as possible; protection user and other beneficial organisms; a kind of suitable plant physiology characteristics are provided; to people and animals' low toxicity, non-stimulated or minimal irritation; crop there is not poisoning, affine to environment, collect pest control treatment and optimize the integrate Avermectin multi-function aqueous emulsion product of body of quality multiple efficacies.
The invention scheme: the composition of its formulation weight percentage is formulated as follows:
Avermectin 0.5～8%; Octachlorodipropyl Ether 0～3%; Refined oil: 10～68%; Numerous emulsifiers: 5～28%; Organic solvent: 0～10%; Plant nutrient substance 2～25%; Film forming base-material: 0～40%; Defoamer: 0～1.5%; Stabilizing agent: 0.5～3%; Antifreezing agent 0～2%; The deionized water surplus.
Described Avermectin is that commercially available Avermectins series pesticide has the Avermectin ointment, the smart powder of Avermectin, the smart powder of ivermectin and the smart powder of emamection benaoate.Molecular formula: C48H72O14 (B1a) C47H70O14 (B1b).Molecular weight: (873.09); (859.06).Physicochemical property: the smart powder of former medicine is white or yellow crystal (containing B1a 〉=90%), density: 1.16, vapour pressure＜200nPa, fusing point 150-155 ℃, in the time of 21 ℃ solvability in water in 7.8 micrograms per litre, the acetone 100, in the toluene 350, isopropyl alcohol 70, chloroform 25 (g/L); Normal temperature is difficult for down decomposing.At 25 ℃, there is not decomposing phenomenon in the solution of pH5-9.
The mode of action and characteristics: tag, stomach toxicity, penetration is strong.It is a kind of macrolide disaccharide compounds.Be the natural products that from edaphon, separates, insect and mite class had tag and stomach poison function and faint fumigation action is arranged, no systemic action.But it has very strong osmosis to blade, can kill subepidermal insect, and the longevity of residure is long.
Described Octachlorodipropyl Ether is a kind of pesticide synergistic agent.Weak yellow liquid.Another name: two (2,3,3,3-tetrachloro propyl group) ether; 1, two (2,3,3, the 3-tetrachloro) propane of 1 '-oxo; S-421 or S2.English name: bis (2,3,3,3-tetrachloropropyl) ether; 1, and 1 '-oxybis (2,3,3,3-tetrachloro-Propane; Octachlorodipropyl ether; Ether, and bis (2,3,3,3-tetrachloropropyl).Molecular formula: C6H6Cl80.Molecular weight: 377.7, proportion: 1.64-1.65, boiling point: 154-155 ℃/mmHg, index of refraction: 1.528-1.529
Described organic solvent is one or more a composition of benzophenone class and solvent naphtha.As toluene, dimethylbenzene, acetone, cyclohexanone etc.Because refined oil has certain solvability, when the less aqueous emulsion product of preparation Avermectin content, can not add other organic solvents.
The composition of one or more of described refined oil employing vegetable oil, reclaimed oil and mineral oil.Vegetable oil is the fat general designation from plant seed, pulp and other extracting section gained, comprises soya-bean oil, rapeseed oil, cocoa butter, palm oil, linseed oil, castor-oil plant wet goods, uses vegetable oil for industry purpose usually.Reclaimed oil comprises the oil of industrial waste oil and the treated regeneration of municipal sewage system abandoned oil, composition more complicated.Mineral oil is meant oil product.Diesel oil emulsion in the conventional art or machine oil emulsion have multiple application in agricultural chemicals, easily produce the light toxic action, cause chemical injury of crops, and blade is come off, and be dangerous to crop.Through a large amount of contrast experiments, the refined oil of selecting for use is carried out the research of chemical injury of crops influence factor, carbon chain lengths, the viscosity of vapo(u)rizing temperature, aromatic hydrocarbons semi-annular jade pendant thing content, product, indexs such as the pH value of product have been carried out integrated survey to the influence of crop.The index of determining refined oil is: unsaturated hydrocarbon content is less than 1%, and boiling point is in 280-450 ℃ of scope, and carbon chain lengths is 18-36C, and viscosity is at 10-80mm2/S, and sulfonated bodies content is less than 5%.Reach These parameters, can avoid poisoning, guarantee its certain desinsection effectiveness again crop.Promptly be called refined oil.
Described film forming base-material; adopt and the affine plant protection film of environment; make plant surface keep the method for continuous rete; as the high fat film product that adopts higher fatty acid and higher aliphatic to synthesize; derive from the biomembrane of plant as primary raw material, platymiscium source avirulence product, its finished product are white " cream " shape aqueous emulsion; aromatic odor is arranged, soluble in water.Be sprayed at that (soil, fruit etc.) can form the invisible molecule rete of naked eyes on plant or other solids, its rete allows oxygen and carbonic acid gas to see through, and hydrone is difficult for seeing through, and when rete is met water, but automatic expansion is kept continuous rete.Though high fat film itself is not had an effect of sterilization, desinsection, but rete can play marvellous physical effect, as the repellent insect, press down the ovum hatching, prevent and treat dehiscent fruit, resist windburn, air pollution preventing, control mini pest (aphid, mite, thrips etc.), reduce rising, promote photosynthesis, increase output, improve multiple efficacies such as quality.
Described emulsifier is several compositions in anion, nonionic, the amphion three class surfactants.In three class surfactants,, and be suitable for producing in batches with the stability and the economic benefit of raising product.As contain alkyl benzene sulphonate system, TX system, NP system, PO system etc.Adopt polynary emulsification method, the emulsifier and the auxiliary agent of at first low HLB value carry out emulsification to oily components, and the emulsifier that adds the composite high HLB value of being made up of anion, nonionic, amphion of kinds of surface activating agent again carries out emulsification to aqueous components.Can oil product is fully emulsified; Make that the preparation emulsifying ability is extremely strong, existing hydrophily has lipophile again, and has stronger detergency, and very strong sterilization, disinfecting power are also arranged simultaneously.Filtering out ten plurality of raw materials reagent in early stage in 300 plurality of raw materials tests.Its prescription is optimized, and the primary raw material in the selection basic recipe is as variable, and less important raw material carries out the test of four factors, three horizontal quadratures as constant, reciprocation cycle, and repeated multiple times is found out optimum formula.In range of doses, has stability preferably.Stability test is the result show, still for stable, all can present uniform and stable white emulsion after heat storage, freezing and centrifugal treating.
Described plant nutrient substance adopts and affine activating agent, the growth regulator of plant, comprises plant growth regulator, foliage fertilizer: as algae essence, compound sodium nitrophenolate, fatty alcohol, polyvinylpyrrolidone, lecithin etc.
It is suspension stabilizer that described stabilizing agent has been chosen ethylenediamine tetra-acetic acid and Magnesiumaluminumsilicate and bentonite.Make this product that the long storage life be arranged, make product not stratified, do not emanate, never degenerate.
Also can add an amount of antioxidant, antifreezing agent, thickener etc. in case of necessity.
Production technology of the present invention and method: divide oiliness and aqueous components in process of production, stir the back respectively and add.With even and stable being dispersed in the preparation of active ingredient of guaranteeing agricultural chemicals.
The first step, Avermectin and organic solvent are mixed to whole dissolvings, add the emulsifier and the auxiliary agent of refined oil, Octachlorodipropyl Ether, low HLB value, stir 20-60 minute, form oily components.
Second step, adopt emulsifier, water-based material and the deionized water of high HLB value to mix, stirred 20-60 minute, form aqueous components;
The 3rd step, above-mentioned oily components and aqueous components were left standstill respectively 20-120 minute, then two kinds of liquid are stirred to mix after 20-60 minute again and stir;
In the 4th step, high speed shear stirred 50-120 minute, added defoamer, stabilizing agent, antifreezing agent and stirred and disperse to make the thick shape aqueous emulsion of milky homogeneous.Check, can, packing, finished product.
Advantage of the present invention and good effect:
1. because the present invention all is dissolved to the former medicine of Avermectin in the oil-phase component earlier, and to make oil be the oil-in-water formulation of continuous phase for disperse phase water, the active ingredient of agricultural chemicals is in oil phase, and the diameter of suspension oil droplet is at micron order.By a large amount of formulation screening tests, determine the formula for a product that physical and chemical performance is the most stable, the water base property product that has solved the Avermectin preparation is easy to generate the technical problem that precipitation is separated out, and has improved the stability in the product storage transportation.
2. because the present invention adopts water to replace organic solvent, and preparation is solvent with water, adopt easily degraded chemicals, reduce aromatics organic solvents such as benzene, dimethylbenzene, and three-waste free discharge aborning, environmental pollution reduced.Toxicity reduces, to the person poultry safety.To eyes minimal irritation and non-stimulated to skin.Natural enemy to insect is hurt less.
3. because the present invention has adopted Octachlorodipropyl Ether, its drug effect is higher than with the missible oil of dosage and other products.
4. because the present invention takes into full account chemical stability, pH value, viscosity, arene content, carbon chain lengths, indexs such as sulfonated bodies content reduce the light toxic action, and plant safety is not had poisoning.
5. because refined oil of the present invention and film forming base-material, be sprayed on plant or other solids, can form the molecule rete, can play marvellous physical effect, as the repellent insect, press down the ovum hatching, resist windburn, air pollution preventing, minimizing transpiration, promote photosynthesis, increase output, improve multiple efficacies such as quality.
6. owing to adopt the numerous emulsifiers of anion, nonionic, amphion composition in the aqueous emulsion component, adopt polynary emulsification method, can oil product is fully emulsified; Make that the preparation emulsifying ability is extremely strong, existing hydrophily has lipophile again.
In a word, the multi-function aqueous emulsion that contains Avermectin have efficiently, stablize, low toxicity, characteristics such as multi-functional.
Embodiment
Embodiment 1:2% abamectin aqueous emulsion has another name called prominent (LA-2) composition prescription (mass percent) of green peace: Avermectin 2%, Octachlorodipropyl Ether 1%, 36# hydraulic oil 65%, polyvinyl alcohol 4.4%, neopelex 2.0%, alkylphenol-polyethenoxy (10) ether 1.2%, octyl phenol polyoxy ethene (4) ether 1.5%, lecithin 1%, aliphatic alcohol polyethenoxy (3) ether 2.1%, polyoxyethylene alkyl ether sulfate sodium 0.5%, ethylenediamine tetra-acetic acid 0.2%, 2,4-potassium hexadiene 0.1%, glycerine 0.5%, 500 order bentonite 1%, deionized water adds to 100%.By technological process, mixing and stirring is made.
Embodiment 2:2.5% Avermectin multi-function aqueous emulsion composition prescription (mass percent): Avermectin 2.5%, Octachlorodipropyl Ether 1.8%, acetone 2%, dimethylbenzene 6%, 30# machine oil 30%, high fat film 18%, polyvinyl alcohol 3%, alkyl benzene calcium sulfonate (farming breast 500) 8%, alkylphenol polyoxyethylene 2%, sorbitan monooleate APEO (polysorbate65) 3.5%, aliphatic acid polyethenoxy ether 2%, compound sodium nitrophenolate 1.2%, phosphoric acid magnalium 0.8%, ethylene glycol 0.4%, deionized water adds to 100%.By technological process, mixing and stirring is made.
Embodiment 3: it is (LA-9) composition prescription (mass percent) that the composite aqueous emulsion of Avermectin and Biphenthrin has another name called green peace: Avermectin 1%, Biphenthrin 1%, Octachlorodipropyl Ether 1.5%, methyl-n-butyl ketone 2%, dimethylbenzene 2.5%, isopropyl alcohol 0.5%, 46# white oil 36%, high fat film 26%, alkylphenol-polyethenoxy (10) ether phosphate 8%, algae essence 2%, coconut oil diethanol amide 0.6%, fatty alcohol-polyoxyethylene ether 2%, polyvinylpyrrolidone 1.6%, deionized water adds to 100%.By technological process, mixing and stirring is made.
Stability test:
By study on the stability, heat storage (54 ± 2 ℃) 14 d are stable, not stratified, newborn analysing not; 0 ℃ ,-5 ℃ 7 d of cold storage are stable, and bad phenomenon such as crystallization, no concentration gradient, no layering are analysed, do not had to agalasisa.Through quality inspection, to detections such as outward appearance, effective ingredient, pH value, stability of emulsion, low-temperature stability heat storage stabilities, the active ingredient resolution ratio is less than 5%.Meet standard-required.
Through the chemical producting safety evaluation test:
Rat acute per os toxicity: occurred flocking together in 20 minutes behind the animal contaminated, poisoning symptom such as movable minimizings, recover normally next day.Viewing duration does not have animal dead.Surviving animals is observed 2 all backs weight increase, and execution is done gross anatomy and do not seen that each internal organs has macroscopic material alterations.According to the GB15670-1995 regulation, no longer carry out the more test of high dose.
According to above-mentioned result of the test, abamectin aqueous emulsion (green peace is prominent) is to male and female rat oral LD
50All greater than 5000mg/kg.Detailed results sees the following form.
Press GB15670-1995 China existing agricultural chemicals acute oral toxicity grade scale, abamectin aqueous emulsion (green peace is prominent) all belongs to low toxicity to male and female rat acute per os toxicity.
2. percutaneous toxicity: animal contaminated is not seen skin irritatin and whole body poisoning symptom after 4 hours, do not occur animal dead in the observation period.Surviving animals is observed 2 all backs weight increase, and execution is done gross anatomy and do not seen that each internal organs has macroscopic material alterations.Press the GB15670-1995 regulation, no longer carry out more high dose test.
According to above-mentioned result of the test, abamectin aqueous emulsion (green peace prominent) to the male and female rat through skin LD50 all greater than 2000mg/kg.Detailed results sees the following form.
Press GB15670-1995 China existing agricultural chemicals acute dermal toxicity grade scale, abamectin aqueous emulsion (green peace is prominent) all belongs to low toxicity to male and female rat acute percutaneous toxicity.
3. rabbit eye mucosa: drip behind the medicine 1 hour visible animal eye conjunctiva mild hyperaemia and hyperemia, with a small amount of secretion, iris and cornea there is no unusually.48 animal conjunctiva sxs, all animals all recovered normal in 72 hours.Detailed results is seen attached list.
Press GB15670-1995 China existing agricultural chemicals eye irritation grade scale, abamectin aqueous emulsion (green peace is prominent) has slight excitant to the rabbit eyes.
4. rabbit skin: behind the coating 4,24,48 hours, animal experiment position and contrast position skin there is no erythema and oedema forms.Detailed results is seen attached list
Press GB15670-1995 China existing agricultural chemicals skin irritation grade scale, abamectin aqueous emulsion (green peace is prominent) is to rabbit skin nonirritant.
Conclusion: check is assert through chemical products safety evaluatio center, and rat acute per os toxicity (LD50) is greater than 5g/kg for abamectin aqueous emulsion (green peace is prominent), and percutaneous toxicity (LD50) is greater than 2g/kg, and to rabbit skin nonirritant, eye mucosa has slight excitant.
The indoor biologically active and the test of pesticide effectiveness:
1. dash forward the indoor biologically active very high, the LC in the time of 48 hours with green peace agricultural-chemical emulsion and abamectin compounded green peace to Tetranychus cinnabarinus
50Be 0.19mg/L, contrast medicament alkynes mite spy is 469.07mg/L to the indoor biologically active of Tetranychus cinnabarinus.Utilize the DPS data processing software, try to achieve abamectin aqueous emulsion (green peace is prominent) and the special LC of alkynes mite
5095% confidence interval of ratio is 0.0003 ~ 0.0005, its confidence interval does not comprise 1, illustrate that abamectin aqueous emulsion (green peace prominent) and alkynes mite spy have significant difference to the indoor biologically active of Tetranychus cinnabarinus, and abamectin aqueous emulsion (green peace is prominent) is significantly higher than alkynes mite spy to the biologically active of Tetranychus cinnabarinus.
2. abamectin aqueous emulsion (green peace is prominent) is to the good indoor biologically active of diamond-back moth, the LC in the time of 48 hours
50Be 1.11mg/L, contrast medicament Hostathion is 721.65mg/L (annotate: the activity of Hostathion is significantly higher than leaf dipping method in dip method) to the indoor biologically active of diamond-back moth.Utilize the DPS data processing software, try to achieve abamectin aqueous emulsion (green peace is prominent) and Hostathion LC
5095% confidence interval of ratio is 0.0008 ~ 0.0028, its confidence interval does not comprise 1, illustrate that abamectin aqueous emulsion (green peace is prominent) and Hostathion have significant difference to the indoor biologically active of diamond-back moth, and the biologically active of abamectin aqueous emulsion (green peace is prominent) diamond-back moth is significantly higher than Hostathion.
Through plant protection unit how the cloth experimental tests use, applicability and safety experiment on the crops such as vegetables, cotton oranges and tangerines, tealeaves are shown: synergistic effect is obvious, to crop safety, no poisoning.
4. through plant protection master station; applicable cases at the oranges and tangerines blade shows: this product also has the plant growing facilitation; can promote the oranges and tangerines leaf growth, make the blade and blade area increase (3%～14%), mesophyll thickens; dry matter increases; (the blade weightening finish reaches 11%～15%) leaf look dark green, and photosynthetic capacity strengthens, and can also strengthen cold tolerance; reduce fallen leaves, thereby improve the quality and the quality of oranges and tangerines greatly.
The Avermectin multi-function aqueous emulsion is a kind of to people and animals' low toxicity, and slight excitant is arranged, and crop is not had poisoning, and is affine to environment, the insecticide of collection pest control treatment and the multiple function of optimization quality.Compare with domestic and international similar technology, have scientific formulation, technology advanced person stablizes low toxicity, the characteristics of broad-spectrum high efficacy.
Claims (10)
1. the aqueous emulsion that contains Avermectin provides a kind of suitable plant physiology characteristics, to people and animals' low toxicity, crop is not had poisoning, and is affine to environment, the aqueous emulsion method of pest control treatment and optimization quality multiple efficacies; It is characterized in that: Avermectin 0.5～8%; Octachlorodipropyl Ether 0～3%; Refined oil 10～68%; Numerous emulsifiers 5～28%; Organic solvent 0～10%; Plant nutrient substance 2～25%; Film forming base-material 0～40%; Defoamer 0～1.5%; Stabilizing agent 0.5～3%; Antifreezing agent 0～2%; The deionized water surplus; And following production technology and method are made:
The first step, former medicine of Avermectin and organic solvent are mixed to dissolving, add the emulsifier and the auxiliary agent of refined oil, Octachlorodipropyl Ether, low HLB value, stir 20-60 minute, form oily components;
Second step, adopt emulsifier, water-based material and the deionized water of high HLB value to mix, stirred 20-60 minute, form aqueous components;
In the 3rd step, above-mentioned oily components and aqueous components were left standstill respectively 20-120 minute;
The 4th step, two kinds of liquid are stirred after 20-60 minute again mix then, high speed shear stirred 50-120 minute, added defoamer, stabilizing agent, antifreezing agent and stirred dispersion, made the thick shape aqueous emulsion of milky homogeneous; Check, can, packing, finished product.
2. the aqueous emulsion that contains Avermectin as claimed in claim 1, it is characterized in that: Avermectin 2%, Octachlorodipropyl Ether 1%, 36# hydraulic oil 65%, polyvinyl alcohol 4.4%, neopelex 2.0%, alkylphenol-polyethenoxy (10) ether 1.2%, octyl phenol polyoxy ethene (4) ether 1.5%, lecithin 1%, aliphatic alcohol polyethenoxy (3) ether 2.1%, polyoxyethylene alkyl ether sulfate sodium 0.5%, ethylenediamine tetra-acetic acid 0.2%, 2,4-potassium hexadiene 0.1%, glycerine 0.5%, 500 order bentonites 1%, deionized water adds to 100%; By technological process, the aqueous emulsion that mixing and stirring is made.
3. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: Avermectin 2.5%, Octachlorodipropyl Ether 1.8%, acetone 2%, dimethylbenzene 6%, 30# machine oil 30%, high fat film 18%, polyvinyl alcohol 3%, alkyl benzene calcium sulfonate (farming breast 500) 8%, alkylphenol polyoxyethylene 2%, sorbitan monooleate APEO (polysorbate65) 3.5%, aliphatic acid polyethenoxy ether 2%, compound sodium nitrophenolate 1.2%, phosphoric acid magnalium 0.8%, ethylene glycol 0.4%, deionized water adds to 100%; By technological process, the aqueous emulsion that mixing and stirring is made.
4. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: Avermectin 1%, Biphenthrin 1%, Octachlorodipropyl Ether 1.5%, methyl-n-butyl ketone 2%, dimethylbenzene 2.5%, isopropyl alcohol 0.5%, 46# white oil 36%, high fat film 26%, alkylphenol-polyethenoxy (10) ether phosphate 8%, algae essence 2%, coconut oil diethanol amide 0.6%, fatty alcohol-polyoxyethylene ether 2%, polyvinylpyrrolidone 1.6%, deionized water adds to 100%.By technological process, the aqueous emulsion that mixing and stirring is made.
5. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: the composition of one or more of refined oil employing vegetable oil, reclaimed oil or mineral oil.
6. the aqueous emulsion that contains Avermectin as claimed in claim 5, it is characterized in that: the index of refined oil is: unsaturated hydrocarbon content is less than 1%, and boiling point is in 280-450 ℃ of scope, and carbon chain lengths is 18-36C, viscosity is at 10-80mm2/S, and sulfonated bodies content is less than 5%.
7. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: emulsifier is several compositions in anion, nonionic, the amphion three class surfactants.
8. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: the film forming base-material adopts higher fatty acid and the synthetic high fat film of higher aliphatic.
9. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: organic solvent is one or more a composition of benzophenone class and solvent naphtha.
10. the aqueous emulsion that contains Avermectin as claimed in claim 1 is characterized in that: plant nutrient substance adopts plant growth regulator and foliage fertilizer: as algae essence, compound sodium nitrophenolate, fatty alcohol, polyvinylpyrrolidone, lecithin.
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| CN102826916A (en) * | 2012-09-21 | 2012-12-19 | 黑龙江禾田丰泽兴农科技开发有限公司 | Method for preparing microemulsion by mixing pesticide, liquid fertilizer and bioemulsifier |
| CN103081929A (en) * | 2013-03-06 | 2013-05-08 | 西南大学 | Mothproof growth promoting suspending agent and preparation method thereof |
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| CN103563927A (en) * | 2012-07-30 | 2014-02-12 | 王玉万 | Plant insecticide containing avermectin B2a and B1a |
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| CN103563927A (en) * | 2012-07-30 | 2014-02-12 | 王玉万 | Plant insecticide containing avermectin B2a and B1a |
| CN102826916A (en) * | 2012-09-21 | 2012-12-19 | 黑龙江禾田丰泽兴农科技开发有限公司 | Method for preparing microemulsion by mixing pesticide, liquid fertilizer and bioemulsifier |
| CN103081929A (en) * | 2013-03-06 | 2013-05-08 | 西南大学 | Mothproof growth promoting suspending agent and preparation method thereof |
| CN103250732A (en) * | 2013-05-02 | 2013-08-21 | 新疆农业科学院植物保护研究所 | Synergistic pesticide composition for killing scale insects |
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| CN109221187A (en) * | 2018-09-28 | 2019-01-18 | 绩溪农华生物科技有限公司 | A kind of disinsection aqueous emulsion and preparation method thereof containing avermectin |
| CN109452269A (en) * | 2018-12-21 | 2019-03-12 | 硅羿科技（上海）有限公司 | Avermectin emulsion formulations and preparation method and application |
| CN109452269B (en) * | 2018-12-21 | 2021-06-01 | 硅羿科技（上海）有限公司 | Abamectin emulsion preparation and preparation method and application thereof |
| CN112970768A (en) * | 2021-02-23 | 2021-06-18 | 广西壮族自治区农业科学院 | Medicament composition for improving spider mite control effect |
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