CN109221187A - A kind of disinsection aqueous emulsion and preparation method thereof containing avermectin - Google Patents
A kind of disinsection aqueous emulsion and preparation method thereof containing avermectin Download PDFInfo
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- CN109221187A CN109221187A CN201811134794.5A CN201811134794A CN109221187A CN 109221187 A CN109221187 A CN 109221187A CN 201811134794 A CN201811134794 A CN 201811134794A CN 109221187 A CN109221187 A CN 109221187A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/14—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing aromatic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds
- A01N57/32—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds containing heterocyclic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
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Abstract
The present invention relates to technical field of pesticide preparations, it more particularly to a kind of disinsection aqueous emulsion containing avermectin, is assembled by the raw material of following parts by weight: 1-5 parts of avermectin, 3-7 parts of active constituent, 10-15 parts of solvent, 4-8 parts of emulsifier, 1-3 parts of surfactant, 5-10 parts of oiliness bentonite, 3-6 parts of dispersing agent, 1-3 parts of thickener, 1-3 parts of stabilizer, 0.6-1 parts of palm oil methyloctanoic acid methyl esters, 0.3-0.7 parts of defoaming agent, 80-100 parts of deionized water；It wherein, further include 5-10 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coated fertilizer is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio composition.Disinsection aqueous emulsion of the invention has double effects, and active principle stabilization coexists and high efficiency dispersion, efficacy stability, storage life are long.
Description
Technical field
The present invention relates to technical field of pesticide preparations, and in particular to a kind of disinsection aqueous emulsion and its preparation containing avermectin
Method.
Background technique
Pesticide emulsion in water refer to raw medicine liquid not soluble in water or raw medicine are dissolved in it is molten obtained by organic solvent not soluble in water
A kind of formulations of pesticide that liquid is dispersed in water.Compared with other traditional formulations of pesticide especially missible oil product, due in aqueous emulsion
Water instead of, as decentralized medium, reducing the dosage of organic solvent for environment and the poisonous and hazardous organic solvent of people and animals, because
This has many advantages, such as environmental protection, without fire hazard, storage and convenient transportation, and aqueous emulsion has become the one of current formulations of pesticide development
A important directions.
The preparation of aqueous emulsion needs that the oil droplet in water phase is broken into micron-sized dispersity by the means of high shear,
Simultaneously by the addition of auxiliary agent is carried out chemistry package, drop low-surface-energy or using surface electric layer repulsive interaction make it is whole
A aqueous emulsion stable system, it is therefore desirable to select suitable raw medicine and suitable surfactant and solvent, can just prepare
Meet the aqueous emulsion of the indexs such as cold (heat) storage stability, dilution stability, pourability, viscosity.
Avermectin (Abamectin) be a kind of wide spectrum, efficiently, the macrolides antibiotics compound of safety, have
Strong desinsection, mite killing, eelworm-killing activity.Avermectin has stomach toxicity and action of contace poison, and no systemic action is unable to ovicidal,
Mechanism of action is by interfering pest nervous physiology activity, and stimulation release γ-aminobutyric acid makes pest central nervous system signal
Constantly receive for motor neuron, paralysis, food refusal, slow-action or motionless so as to cause death rapidly, is widely used within a few hours
Prevent and treat the pests such as crops diamondback moth, the cabbage caterpillars such as vegetables, fruit tree.
However, in the real process of agricultural production, the problem of pest control most easily produces is the production of pest resistance to insecticide
It is raw.Different cultivars ingredient is compounded, and is to prevent and treat the very common method of resistant insect.Therefore desinsection is being carried out using avermectin
When, it needs to be equipped with other active components.However heterogeneity is compounded, and chemical reaction occurs each other and causes shadow to drug effect
It rings.
Disclose a kind of pesticide emulsion in water in invention patent mandate notification number CN101627764B, the chemicals it is effective
Ingredient is avermectin and Rynaxypyr, further includes solvent, surfactant and other auxiliary agents in preparation.The skill of the invention
Art scheme is to carry out emulsion dispersion after mixing two class active principles, function additive, organic solvent and water, thus the multiple-effect system of obtaining
Agent, avermectin and Rynaxypyr are respectively bacteria remover and insecticide, because both the above substance is pulvis, and mutually
Between be not easy anti-biochemical reaction, therefore the compound formulation prepared has dual drug effect, and effect is relatively stable.But for
The substance of other kinds of difference drug effect is difficult shape if still prepared using the method for producing aqueous emulsion of the invention
At stability emulsion system, can there are problems that the validity loss of drug or stability decline.
Weatherability and storage stability are also a pesticidal preparations important performance in need of consideration, conventional aqueous emulsion because
It is that water oil meets system, therefore there is a problem of that stability is poor, such as disclosed in license notification number CN101669480B
In pesticide emulsion in water and preparation method thereof, by the way that builder and ethylene glycol, propylene glycol, hexylene glycol, diethylene glycol (DEG), 1,3- fourth is added
Glycol etc. improves the resistance to frost of preparation, so that pesticidal preparations are more cold-resistant, will not cause the dispersion of drug in frozen-thaw process
Property reduce or drug effect the problem of losing.But this medicament still remains preparation heat resistance deficiency and drug suspends surely
Qualitative poor problem, this makes the validity period of medicament shorter, not can be carried out and saves for a long time.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of disinsection aqueous emulsion and its system containing avermectin
Preparation Method, the disinsection aqueous emulsion have double effects, and active principle stabilization coexists and high efficiency dispersion, efficacy stability, and storage is effective
Phase is long.
In order to achieve the above object, the present invention is achieved through the following technical solutions:
A kind of disinsection aqueous emulsion containing avermectin, the aqueous emulsion are assembled by the raw material of following parts by weight: AVM hereinafter
1-5 parts of rhzomorph, 3-7 parts of active constituent, 10-15 parts of solvent, 4-8 parts of emulsifier, 1-3 parts of surfactant, oiliness bentonite 5-
10 parts, 3-6 parts of dispersing agent, 1-3 parts of thickener, 1-3 parts of stabilizer, 0.6-1 parts of palm oil methyloctanoic acid methyl esters, defoaming agent 0.3-
0.7 part, 80-100 parts of deionized water；
It wherein, further include 5-10 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio
Composition.
Preferably, the aqueous emulsion is assembled by the raw material of following parts by weight: 3 parts of avermectin, activity at
Points 5 parts, 12 parts of solvent, 6 parts of emulsifier, 2 parts of surfactant, 7.5 parts of oiliness bentonite, 4.5 parts of dispersing agent, 2 parts of thickener,
2 parts of stabilizer, 0.8 part of palm oil methyloctanoic acid methyl esters, 0.5 part of defoaming agent, 90 parts of deionized water；
It wherein, further include 7.5 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio
Composition.
Preferably, the active constituent be selected from following one or more: carbosulfan, Hostathion,
Diazinon, mite prestige be more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Preferably, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Preferably, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene
Wool alcohol ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, polyoxyethylene
It is one or more of in castor oil.
Preferably, in the surfactant anionic surfactant containing 65wt% and 35wt% it is non-
Ionic surface active agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol poly-
Ethylene oxide ether phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or poly- second
Vinyl acetate.
Preferably, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresols-first
Aldehyde condensate sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt,
One or more of styrene-succinic anhydride copolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener
For one of hydroxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose.
Preferably, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tertiary fourth
At least one of base hydroquinone.
Preferably, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 85-95 DEG C, with the revolving speed decentralized processing 10-14min of 400-450r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with 450-550r/min
Revolving speed be uniformly dispersed, then coating avermectin and surfactant are added in Scattered Kettle, continue decentralized processing 5-
10min obtains oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 40-50
DEG C temperature dispersion handle 6-8min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 18-22min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Major technique innovative point of the invention is:
(1) containing avermectin and active constituent in disinsection aqueous emulsion of the invention, two kinds of drugs have the function of desinsection,
By coordinated, it is insufficient to solve the problems, such as single medicament insecticidal effect, and pest can be reduced for the anti-of single medicament
The generation of property, increases the service life of medicament, in addition, the preparation method provided through the invention, it can be by two kinds of drug substance stables
It is scattered in aqueous emulsion, avoids chemical reaction occurs between drug impacting drug effect, and drug is stablized point
It dissipates in emulsion system, sedimentation, coalescence and the effect of other physical deteriorations will not occur, improve the stability of pesticide and be stored with
The effect phase.
(2) it in the present invention, avoids avermectin and active constituent that drug effect conflict occurs, is by being covered to avermectin
What film process was realized, methyl methacrylate, attapulgite, N, N-methylene bisacrylamide acyl are utilized in technical solution of the present invention
The ingredients such as amine, polyglycol ether form a kind of special functional film layer on avermectin surface, the functional membrane can to drug into
Row effectively cladding, prevents drug from revealing in lotion, and functional membrane is after drug sprays, due to the oxygen of nature multiple factors
Change effect can gradually discharge internal active principle, to play drug effect.
(3) present invention makes a kind of controllable effective component release speed by the way that avermectin is carried out coating processing
The dosage form of degree, therefore according to its purposes, determines the thickness of membranous wall to control rate of release, required to achieve the effect that.
(4) solvent in instant component and dispersing agent can obtain oil for avermectin and active constituent are fully dispersed
Phase, oiliness bentonite and palm oil methyloctanoic acid methyl esters can generate synergistic effect, have fabulous synergistic effect, water can be improved
The stability of emulsion preparations.
Specific embodiment
Below with reference to embodiment, further description of the specific embodiments of the present invention, and following embodiment is only used for more
Technical solution of the present invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
Embodiment 1
The disinsection aqueous emulsion containing avermectin of the present embodiment, the aqueous emulsion assembled by the raw material of following parts by weight and
At: 1 part of avermectin, 3 parts of active constituent, 10 parts of solvent, 4 parts of emulsifier, 1 part of surfactant, oiliness bentonite 5 part, point
3 parts of powder, 1 part of thickener, 1 part of stabilizer, 0.6 part of palm oil methyloctanoic acid methyl esters, 0.3 part of defoaming agent, 80 parts of deionized water；
It wherein, further include 5 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating material
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 group in mass ratio
At.
Wherein, the active constituent is selected from following one or more: carbosulfan, Hostathion, diazinon, mite
Prestige is more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Wherein, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Wherein, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene lanonol
Ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, Emulsifier EL-60
Middle one or more.
Wherein, in the surfactant anionic surfactant containing 65wt% and 35wt% non-ionic surface
Activating agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether
Phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
Wherein, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensation product
Sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-fourth
One or more of anhydride multipolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener is that methylol is fine
One of dimension element, hydroxyethyl cellulose and hydroxypropyl cellulose.
Wherein, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tert-butyl to benzene two
At least one of phenol.
Wherein, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 85 DEG C, with the revolving speed decentralized processing 10min of 400r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 450r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 5min, obtains
Oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 40 DEG C
Temperature dispersion handle 6min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 18min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Embodiment 2
The disinsection aqueous emulsion containing avermectin of the present embodiment, the aqueous emulsion assembled by the raw material of following parts by weight and
At: 5 parts of avermectin, 7 parts of active constituent, 15 parts of solvent, 8 parts of emulsifier, 3 parts of surfactant, oiliness bentonite 10 part, point
6 parts of powder, 3 parts of thickener, 3 parts of stabilizer, 1 part of palm oil methyloctanoic acid methyl esters, 0.7 part of defoaming agent, 100 parts of deionized water；
It wherein, further include 10 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating material
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 group in mass ratio
At.
Wherein, the active constituent is selected from following one or more: carbosulfan, Hostathion, diazinon, mite
Prestige is more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Wherein, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Wherein, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene lanonol
Ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, Emulsifier EL-60
Middle one or more.
Wherein, in the surfactant anionic surfactant containing 65wt% and 35wt% non-ionic surface
Activating agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether
Phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
Wherein, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensation product
Sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-fourth
One or more of anhydride multipolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener is that methylol is fine
One of dimension element, hydroxyethyl cellulose and hydroxypropyl cellulose.
Wherein, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tert-butyl to benzene two
At least one of phenol.
Wherein, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 95 DEG C, with the revolving speed decentralized processing 14min of 450r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 550r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 10min, obtains
To oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 50 DEG C
Temperature dispersion handle 8min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 22min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Embodiment 3
The disinsection aqueous emulsion containing avermectin of the present embodiment, the aqueous emulsion assembled by the raw material of following parts by weight and
At: 3 parts of avermectin, 5 parts of active constituent, 12 parts of solvent, 6 parts of emulsifier, 2 parts of surfactant, 7.5 parts of oiliness bentonite,
4.5 parts of dispersing agent, 2 parts of thickener, 2 parts of stabilizer, 0.8 part of palm oil methyloctanoic acid methyl esters, 0.5 part of defoaming agent, deionized water
90 parts；
It wherein, further include 7.5 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio
Composition.
Wherein, the active constituent is selected from following one or more: carbosulfan, Hostathion, diazinon, mite
Prestige is more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Wherein, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Wherein, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene lanonol
Ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, Emulsifier EL-60
Middle one or more.
Wherein, in the surfactant anionic surfactant containing 65wt% and 35wt% non-ionic surface
Activating agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether
Phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
Wherein, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensation product
Sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-fourth
One or more of anhydride multipolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener is that methylol is fine
One of dimension element, hydroxyethyl cellulose and hydroxypropyl cellulose.
Wherein, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tert-butyl to benzene two
At least one of phenol.
Wherein, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 90 DEG C, with the revolving speed decentralized processing 12min of 430r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 500r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 7.5min, obtains
To oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 45 DEG C
Temperature dispersion handle 7min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 20min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Embodiment 4
The disinsection aqueous emulsion containing avermectin of the present embodiment, the aqueous emulsion assembled by the raw material of following parts by weight and
At: 2 parts of avermectin, 4 parts of active constituent, 11 parts of solvent, 5 parts of emulsifier, 1.5 parts of surfactant, 6 parts of oiliness bentonite,
4 parts of dispersing agent, 1.5 parts of thickener, 1.5 parts of stabilizer, 0.7 part of palm oil methyloctanoic acid methyl esters, 0.4 part of defoaming agent, deionization
85 parts of water；
It wherein, further include 6 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating material
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 group in mass ratio
At.
Wherein, the active constituent is selected from following one or more: carbosulfan, Hostathion, diazinon, mite
Prestige is more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Wherein, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Wherein, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene lanonol
Ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, Emulsifier EL-60
Middle one or more.
Wherein, in the surfactant anionic surfactant containing 65wt% and 35wt% non-ionic surface
Activating agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether
Phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
Wherein, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensation product
Sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-fourth
One or more of anhydride multipolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener is that methylol is fine
One of dimension element, hydroxyethyl cellulose and hydroxypropyl cellulose.
Wherein, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tert-butyl to benzene two
At least one of phenol.
Wherein, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 88 DEG C, with the revolving speed decentralized processing 11min of 410r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 480r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 6min, obtains
Oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 43 DEG C
Temperature dispersion handle 6.5min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 19min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Embodiment 5
The disinsection aqueous emulsion containing avermectin of the present embodiment, the aqueous emulsion assembled by the raw material of following parts by weight and
At: 4 parts of avermectin, 6 parts of active constituent, 14 parts of solvent, 7 parts of emulsifier, 2.5 parts of surfactant, 9 parts of oiliness bentonite,
5 parts of dispersing agent, 2.5 parts of thickener, 2.5 parts of stabilizer, 0.9 part of palm oil methyloctanoic acid methyl esters, 0.6 part of defoaming agent, deionization
95 parts of water；
It wherein, further include 9 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coating material
Material is by methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 group in mass ratio
At.
Wherein, the active constituent is selected from following one or more: carbosulfan, Hostathion, diazinon, mite
Prestige is more, chlopyrifos, cyfluthrin, Tefluthrin, lythidathion, phoxim.
Wherein, the solvent is at least one of toluene, dimethylbenzene, cyclohexanone.
Wherein, the emulsifier is selected from anhydrous sorbitol laurate, polyoxyethylene laurel ether, polyoxypropylene lanonol
Ether, polyoxyethylene monopalmitate, polyoxyethylene sorbitol lanolin, polyoxyl 40 stearate, Emulsifier EL-60
Middle one or more.
Wherein, in the surfactant anionic surfactant containing 65wt% and 35wt% non-ionic surface
Activating agent；Anionic surfactant selects alpha-alkene sulfonate, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether
Phosphate；Nonionic surfactant selects Tween-80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
Wherein, the dispersing agent is selected from aromatic sulphonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensation product
Sulfonate, C4-C11 alkene and copolymer-maleic anhydride sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-fourth
One or more of anhydride multipolymer sodium, polymerization of carboxylic acid sodium salt, alkyl pyrrolidone；The thickener is that methylol is fine
One of dimension element, hydroxyethyl cellulose and hydroxypropyl cellulose.
Wherein, the stabilizer is 2,6-di-tert-butyl p-cresol, tertiary butyl-4-hydroxy anisole, tert-butyl to benzene two
At least one of phenol.
Wherein, the defoaming agent is one of poly- alkyl silicon ethylene oxide, tributyl phosphate.
The present invention also provides the preparation methods of the above-mentioned disinsection aqueous emulsion containing avermectin, include the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, heat
To 92 DEG C, with the revolving speed decentralized processing 13min of 440r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, be then sprayed at coated fertilizer made from step (1)
The avermectin surface after preheating carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 530r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 9min, obtains
Oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 48 DEG C
Temperature dispersion handle 7.5min, obtain aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm fibre is then added
Palmitic acid oil methyl methyl caprylate, ultrasonic emulsification handle 21min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
Comparative example 1
Using pesticide emulsion in water made from license notification number CN101627764B.
Comparative example 2
Using pesticide emulsion in water made from license notification number CN101669480B.
Comparative example 3
Compared with Example 1, difference is only that avermectin does not carry out cladding processing to this comparative example.
Comparative example 4
Compared with Example 1, difference is only that in component that unused oiliness bentonite and palm oil methyl are pungent to this comparative example
Sour methyl esters.
Test example 1
The drug effect of disinsection aqueous emulsion in the present embodiment and comparative example is tested, efficacy testing includes the killing rate of insecticidal test,
Specific test result is shown in Table 1:
Table 1
The above test data discovery is analyzed, compared with comparative example, two kinds in the disinsection aqueous emulsion in the present embodiment are effectively
Ingredient maintains good drug effect, and pharmaceutical properties it may be concluded that utilize skill of the invention generally 99% or more
The disinsection aqueous emulsion of art scheme preparation, can stablize the dual drug effect for keeping two kinds of drugs.
Test example 2
The stability of pesticide emulsion in water in the present embodiment and comparative example is tested, stability passes through freezing-thawing test and high temperature respectively
Storage stability test is detected, and detects the drug suspendability difference under different condition respectively；The circulation time of freezing-thawing test
Number is 3 times, and the storage requirement of high-temperature storage stability is 58 ± 1 DEG C, 30d.
Wherein the test method of suspendability is as follows:
150 milliliters of standard hard water is weighed in 250 milliliters of beakers.Magnetic stirring apparatus is placed in beaker, and will be burnt
Cup is placed on mixing platform.The speed of mixing platform is set so that vortex will not reach stirring rod.By 5 grams of suspension composition
It then weighs and is put into beaker in weighing boat, timer starts immediately and is set as 2 minutes, and by suspension composition
Agitator speed is adjusted after being added in beaker to ensure good mixing.After mixing 2 minutes, beaker is taken from mixing platform
Under, it takes out magnetic stirring apparatus and is rinsed with the wash bottle for filling standard hard water, the content of beaker is then poured into 250 milliliters of graduated cylinders
In, beaker is rinsed, wash water is added in 250 milliliters of graduated cylinders.The volume in graduated cylinder is adjusted to 250 milli of highest with standard hard water
It rises.The step of emptying and rinse the beaker is completed in 1 minute.Then by 250 milliliters of graduated cylinder sealings, and with each cycle 2-3
Second overturns 15 periods, it is then enabled to be kept for interference-free 30 minutes at ambient temperature.Then pipette is used in 10-25 seconds
The suspension for extracting 225 milliliters out from 250 milliliters of graduated cylinders is always to maintain liquid level in lower than 250 milliliters graduated cylinders of pipette tip
Only several millimeters, pay attention to reducing the disturbance to entire graduated cylinder to the greatest extent.Discard the liquid extracted out with pipette.Dry evaporating dish is weighed into
Close to 0.05 gram.The remaining 25 milliliters particles being contained therein with suspension in 250 milliliters of graduated cylinders are rotated, and by this 250 milliliters
The content of graduated cylinder is poured into the evaporating dish.250 milliliters of graduated cylinders are rinsed, wash water is added in evaporating dish.With i.e. by evaporating dish
It is placed into drying oven and dries whole night.When the content of evaporating dish is dry, evaporating dish is taken out from furnace, enables it about
21 DEG C of holding at room temperature 5 minutes.Then evaporating dish is weighed.By from the solid masses of suspension composition initial sample
The weight of residue in evaporating dish is subtracted, then obtains the result divided by the weight of residue in evaporating dish and multiplied by 100%
The test result of suspendability is shown in Table 2.
Table 2
The above experimental result discovery is analyzed, the cold resistance and heat resistance of pesticide emulsion in water provided in this embodiment are more excellent
Show, the high stability of preparation can effectively be kept in the suspendability of frozen process experiment and high temperature storage test, suspendability compared with
Comparative example is also more outstanding.
In conclusion creativeness of the invention is mainly reflected in the following:
(1) containing avermectin and active constituent in disinsection aqueous emulsion of the invention, two kinds of drugs have the function of desinsection,
By coordinated, it is insufficient to solve the problems, such as single medicament insecticidal effect, and pest can be reduced for the anti-of single medicament
The generation of property, increases the service life of medicament, in addition, the preparation method provided through the invention, it can be by two kinds of drug substance stables
It is scattered in aqueous emulsion, avoids chemical reaction occurs between drug impacting drug effect, and drug is stablized point
It dissipates in emulsion system, sedimentation, coalescence and the effect of other physical deteriorations will not occur, improve the stability of pesticide and be stored with
The effect phase.
(2) it in the present invention, avoids avermectin and active constituent that drug effect conflict occurs, is by being covered to avermectin
What film process was realized, methyl methacrylate, attapulgite, N, N-methylene bisacrylamide acyl are utilized in technical solution of the present invention
The ingredients such as amine, polyglycol ether form a kind of special functional film layer on avermectin surface, the functional membrane can to drug into
Row effectively cladding, prevents drug from revealing in lotion, and functional membrane is after drug sprays, due to the oxygen of nature multiple factors
Change effect can gradually discharge internal active principle, to play drug effect.
(3) present invention makes a kind of controllable effective component release speed by the way that avermectin is carried out coating processing
The dosage form of degree, therefore according to its purposes, determines the thickness of membranous wall to control rate of release, required to achieve the effect that.
(4) solvent in instant component and dispersing agent can obtain oil for avermectin and active constituent are fully dispersed
Phase, oiliness bentonite and palm oil methyloctanoic acid methyl esters can generate synergistic effect, have fabulous synergistic effect, water can be improved
The stability of emulsion preparations.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although referring to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features.It is all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of disinsection aqueous emulsion containing avermectin, which is characterized in that the aqueous emulsion is assembled by the raw material of following parts by weight
It forms: 1-5 parts of avermectin, 3-7 parts of active constituent, 10-15 parts of solvent, 4-8 parts of emulsifier, 1-3 parts of surfactant, oiliness
5-10 parts of bentonite, 1-3 parts of thickener, 1-3 parts of stabilizer, 0.6-1 parts of palm oil methyloctanoic acid methyl esters, disappears at 3-6 parts of dispersing agent
0.3-0.7 parts of infusion, 80-100 parts of deionized water；
It wherein, further include 5-10 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coated fertilizer
By methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio composition.
2. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the aqueous emulsion is by following heavy
Amount part raw material assemble: 3 parts of avermectin, 5 parts of active constituent, 12 parts of solvent, 6 parts of emulsifier, 2 parts of surfactant,
7.5 parts of oiliness bentonite, 4.5 parts of dispersing agent, 2 parts of thickener, 2 parts of stabilizer, 0.8 part of palm oil methyloctanoic acid methyl esters, defoaming
0.5 part of agent, 90 parts of deionized water；
It wherein, further include 7.5 parts of coated fertilizer, the coated fertilizer is for coating avermectin, and coated fertilizer
By methyl methacrylate, attapulgite, N, N-methylene-bisacrylamide, polyglycol ether 8:5:3:1 in mass ratio composition.
3. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the active constituent is selected from down
The one or more of column: carbosulfan, Hostathion, diazinon, mite prestige be more, chlopyrifos, cyfluthrin, Tefluthrin,
Lythidathion, phoxim.
4. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the solvent is toluene, two
At least one of toluene, cyclohexanone.
5. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the emulsifier is selected from dehydration
Sorbitan laurate, polyoxyethylene laurel ether, polyoxypropylene wool alcohol ether, polyoxyethylene monopalmitate, polyoxyethylene mountain
It is pears alcohol lanolin, polyoxyl 40 stearate, one or more of in Emulsifier EL-60.
6. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that contain in the surfactant
There are the anionic surfactant of 65wt% and the nonionic surfactant of 35wt%；Anionic surfactant selects α-alkene
Sulfonated hydrocarbon, lignosulfonates or triphenyl vinyl phenol polyoxyethylene ether phosphate；Nonionic surfactant selects poly- mountain
Pear ester -80, alkyl glycosides, vinyl pyrrolidone or polyvinyl acetate.
7. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the dispersing agent is selected from fragrance
Race's sulfonate, acrylic acid and acrylic ester copolymers, cresol/formaldehyde condensate sulfonates, C4-C11 alkene and maleic anhydride
Object sodium salt, maleic anhydride-isobutylene copolymers sodium salt, styrene-succinic anhydride copolymer sodium, polymerization of carboxylic acid sodium salt,
One or more of alkyl pyrrolidone；The thickener is hydroxymethyl cellulose, hydroxyethyl cellulose and hydroxy propyl cellulose
One of element.
8. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the stabilizer is 2,6- bis-
At least one of Butylated Hydroxytoluene, tertiary butyl-4-hydroxy anisole, tert-butyl hydroquinone.
9. the disinsection aqueous emulsion according to claim 1 containing avermectin, which is characterized in that the defoaming agent is poly- alkyl
One of silicon ethylene oxide, tributyl phosphate.
10. the preparation method of -9 described in any item disinsection aqueous emulsions containing avermectin, feature exist according to claim 1
In including the following steps:
(1) prepare coated fertilizer each component according to mass fraction, component raw material is added in sealed reaction kettle, is heated to
85-95 DEG C, with the revolving speed decentralized processing 10-14min of 400-450r/min, it is spare to obtain coated fertilizer；
(2) avermectin is placed in coating equipment in sugar production line and is heated, coated fertilizer made from step (1) is then sprayed at preheating
The avermectin surface afterwards carries out coating, and dry, coating avermectin is spare；
(3) according to mass fraction, active constituent, solvent and dispersing agent are added in Scattered Kettle, with turning for 450-550r/min
Speed is uniformly dispersed, and then coating avermectin and surfactant are added in Scattered Kettle, continues decentralized processing 5-10min,
Obtain oil phase composition；
(4) emulsifier, thickener, stabilizer, defoaming agent and deionized water are mixed, is added in reaction kettle, with 40-50 DEG C
Temperature dispersion handles 6-8min, obtains aqueous phase composition；
(5) aqueous phase composition and oil phase composition are added sequentially in Scattered Kettle, oiliness bentonite and palm oil is then added
Methyloctanoic acid methyl esters, ultrasonic emulsification handle 18-22min, the disinsection aqueous emulsion containing avermectin needed for obtaining.
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Application publication date: 20190118 |