CN109418611A

CN109418611A - One kind preventing hepatic feed addictive and preparation method thereof

Info

Publication number: CN109418611A
Application number: CN201710715612.2A
Authority: CN
Inventors: 刘亮基
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-08-20
Filing date: 2017-08-20
Publication date: 2019-03-05

Abstract

It the invention discloses hepatic feed addictive is prevented, is calculated by mass percentage, comprising: bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5-5%, enzyme preparation 0.2-20% and auxiliary material 30.1-60%.The present invention carries out scientific compatibility with each ingredient of bile acid, curcumin, L-carnitine, multi-vitamins and complex enzyme formulation, prepared drug can effectively prevent the liver diseases such as aquatic livestock fatty liver, liver and gall syndrome, improve survival rate, promote the digestion and absorption of aquatic livestock nutriment, promote animal growth rate, shorten the culture-cycle, reduce feed coefficient, is suitble to the production market demand of feed addictive；The preparation method operating method for preventing hepatic feed addictive of the invention is simple, and raw material sources used are stablized, and low in cost, process controllability is strong, can produce and above-mentioned prevent hepatic feed addictive.

Description

One kind preventing hepatic feed addictive and preparation method thereof

Technical field

The present invention relates to a kind of technical fields of aquatic products feed additives more particularly to one kind to prevent hepatic feed addictive And preparation method thereof.

Background technique

Liver is an organ based on metabolic function, is generating bile, removing toxic substances, blood coagulation, immune, generation energy, water With very important effect is played in the adjusting of electrolyte, up to 1500 kinds or more of the chemical reaction occurred in liver, because This is also considered as one huge " chemical plant ".This is because its unique morphology and history structure and Characteristics of Chemical Constituents, are assigned The complicated and diversified biochemical function of liver is given.

Firstly, the blood supply of liver is very rich, there is arteria hepatica and pylic double blood supply, so that liver is thin Born of the same parents can not only obtain sufficient oxygen and metabolin from arteria hepatica, but also the largely various battalion by intestinal absorption can be obtained from portal vein Substance is supported, these are all that the various metabolisms of liver progress have established material base.Secondly, there are vena hepaticas and biliary tract system for liver It unites dual output channel.Vena hepatica is connected with body circulation, and the metabolite in liver can be transported to its hetero-organization and utilize or be discharged In vitro；Biliary system is communicated with enteron aisle, the bile of hepatic secretion is discharged into enteron aisle, and some metabolic wastes are discharged simultaneously.

Based on these above-mentioned features, liver is not only in the metabolisms such as sugar, lipid, protein, vitamin, hormone Central Position, but also the physiological function with bioconversion, secretion and excretion etc., therefore, nourishing and protecting liver just seems outstanding It is important.In view of the dual channel system of liver, the performance of metabolic function is highly dependent upon enteron aisle, and hepato-enteric circulation is wherein heavy The ring wanted.

Bile acid in bile is the essential substance of lipid food digestion, and primary bile acid flows into enteron aisle with bile, While promoting lipid to digest and assimilate, become secondary bile acid by bacterial action in enteron aisle, the bile acid of enteral there are about 95% by intestinal wall reabsorption (including active reabsorption and passive reabsorption), and re-absorbed bile acid trans-portal vein returns liver, warp After liver cell processing, it is discharged into enteron aisle through biliary tract again together with newly synthesized bile acid, this process is known as the hepato-enteric circulation of bile acid.

The meaning of hepato-enteric circulation is to improve bile availability, the digestion and absorption such as promotion lipid, while can also remove intestines Road endotoxin safeguards intestinal health.When compromised liver function, enteron aisle is possible to be contaminated；Conversely, intestinal flora loses It adjusts, is likely to that liver can be poisoned.Therefore, nourishing and protecting liver must have the integrated idea of liver sausage health care, and intestines two are protected in nourishing the liver Person is inseparable.

Under the conditions of intensive high-density breeding, breeding environment deteriorates, largely using anti-in antibiotic medicine, feedstuff Presence of trophic factors etc. all can cause to damage to cultivated animals liver and gallbladder, cause to occur becoming main with liver and bladder disease in current cultivation Want the disease in the liver and gallbladder syndrome of feature.Hepatic disease causes liver function that obstacle occurs, and influences being absorbed and utilized for nutriment, exempts from Epidemic disease function reduces, anti-stress ability and premunition decline, and then influences aquatic livestock normal growth, and culture efficiency is caused to be damaged Evil.

Summary of the invention

It is an object of the invention to aiming at the deficiencies in the prior art, provide a kind of liver protecting used for aquiculture Feed addictive, the feed addictive can be effectively improved hepato-enteric circulation, effectively prevent animal hepatopathy, promote the life of aquatic livestock Order power and health degree；The preparation method of the feed addictive, preparation process is easy, low production cost, promotes aquatic livestock rouge Fat metabolism reduces the generation of aquatic products fatty liver, promotes aquatic health growth.

To achieve this purpose, the present invention adopts the following technical scheme:

One kind preventing hepatic feed addictive, is calculated by mass percentage, comprising: bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5-5%, enzyme preparation 0.2-20% and auxiliary material 30.1-60%.

It illustrates, Vitamin U is selected as multi-vitamins, and enzyme preparation is preferably complex enzyme formulation.It is directed to existing cultivation Existing insufficient during aquatic products, feed addictive of the invention is used with bile acid, curcumin, L-carnitine, the life of compound dimension A variety of Hepatoprotective cholagogue drugs as main component such as element and complex enzyme formulation compound, and are free of any poisonous and harmful element, both It is safe and effective, the fatty infiltration of liver of aquatic livestock can be prevented, its liver function is enhanced, the absorption efficiency of feed is improved, promotees Water inlet produces growth of animal and improves its survival rate.

It further explains, bile acid and L-carnitine play an important role in fat metabolism, can effectively prevent to support Grow animal nutritional disease in the liver and gallbladder；Curcumin can remove the intracorporal free radical of animal with liver protection, cholagogue, protect liver, improve liver Dirty function promotes bile secretion and the inflammation that diminishes inflammation；Complex enzyme formulation effectively facilitate aquatic livestock to the digestion of nutriment and It absorbs, reduces the generation of intestinal endotoxin, so that the probability that intestinal endotoxin during hepato-enteric circulation absorbs damage liver is reduced, Effectively improve feed digestibility；Animal immune function, anti-stress ability and production performance then can be enhanced in multi-vitamins.

Above-mentioned each substance rational proportion, synergistic effect can effectively restore the hepar damnification of aquatic livestock and improve immune function Can, promote the autoimmunity and premunition of aquatic livestock, to reach aquatic livestock normal growth, improves economic benefit of aquaculture Purpose.

It further explains, the multi-vitamins are vitamin A, vitamin B1, vitamin B2, niacinamide, vitamin One or more combinations of B6, vitamin E, vitamin C, calcium pantothenate, folic acid and vitamin B12.

The multi-vitamins are supplemented, the necessary nutritional supplementation vitamin of the aquatic livestocks such as fish can improve fish body Nutritional status；Multi-vitamins itself have therapeutic effect simultaneously, can reinforce the disease resistance of fish body, and auxiliary removing toxic substances promotes liver The reparation of dirty damage and the regeneration of liver cell, promote physical recovery.The function of said vitamin is well known in the art adds Addition point, performance is without burdensome explanation.

It further explains, the complex enzyme formulation is neutral proteinase, cellulase, phytase, lipase, starch One or more combinations of enzyme, zytase and dextranase.

The complex enzyme formulation is exogenous enzymes, and addition exogenous enzymes effectively facilitate digestion and suction of the aquatic livestock to nutriment It receives, reduces the generation of intestinal endotoxin, to reduce the probability that intestinal endotoxin during hepato-enteric circulation absorbs damage liver, have Effect improves feed digestibility, promotes growth of animals or poultry.

It further explains, the auxiliary material is silica, maltodextrin and starch, accounts for the prevention and treatment hepatopathy feed and adds The mass percent of agent is added to be respectively as follows: silica 0.1-3%；Maltodextrin 20-37%；Starch 10-20%.

The higher river sand of silicone content can be used in silica, and as the carrier of feed addictive, the main aquatic products that increases is moved The WeiDongLi Capsule of object helps to digest, and square is applied in poultry feed, while the feed addition by adding the silica Agent has preferable mobility and anticaking capacity, convenient for the feeding of aquatic livestock.

Malt lake essence is to have with preferable emulsification and thickening effect and promote formed product and inhibit well The effect of product institutional framework, moldability can be good, can prevent deformation of products from can improve product appearance again, easily be absorbed, extensively Basic auxiliary material applied to feed product.

The starch is preferably alphalise starch, and is pre-gelatinized starch, facilitates the forming of particle and guarantees certain particle Hardness and durability increase the stability of aquatic feeds in water, reduce the dust in process, increase caking property, avoid Feed is easy to loosely in water, so that aquatic livestock ingests and prevent being scattered and being lost for nutriment.These are this field Known content, no longer additionally repeats.

Preferably, the vitamin is made of vitamin B1, vitamin B2, niacinamide, vitamin B6 and calcium pantothenate Multi-vitamins.The gastric digestion of vitamin B1 promotion aquatic livestock；Vitamin B2 is restored and is adjusted to aquatic livestock vivo oxidation Ganglion cell's breathing plays an important role, and can improve the utilization rate of feed；Vitamin B2 is relatively to attach most importance in B family vitamin to aquatic livestock It wants, and is not easy a kind of vitamin met, aquatic livestock is easy to appear deficiency disease, it should be noted that supply；Calcium pantothenate is coacetylase Component part, participates in carbohydrate, fat and protein metabolism, and the utilization of calcium pantothenate and vitamin B2 has a substantial connection, and one Another kind requirement increases when kind lacks；In addition, calcium pantothenate is very unstable, it is easy to be damaged when mixing with feed；Vitamin B6 It is the important vitamin for participating in sugar, fat and protein metabolism；Niacinamide is the component part of Coenzyme I and Coenzyme I I, is become perhaps The coenzyme of more dehydrogenases.

Using above-mentioned five kinds of substances as the multi-vitamins, the nutritional status of aquatic livestock is improved significantly, can be added The disease resistance of strong fish body promotes the reparation of hepar damnification and the regeneration of liver cell.

Preferably, the enzyme preparation is the complex enzyme formulation being made of neutral proteinase, cellulase and amylase.Pass through Protein digestibility is greatly improved after neutral proteinase is added, after amylase is added, the digestibility of starch, cellulose can be improved Enzyme can activate the secretion of endogenous enzymes, supplement the deficiency of endogenous enzymes, and be adjusted to endogenous enzymes, guarantee that animal normally digests suction Function is received, diseases prevention and somatotrophic is played the role of.

Using above-mentioned three kinds of substances as the complex enzyme formulation, promote digestion of the aquatic livestock to nutriment significantly And absorption, the generation of intestinal endotoxin is reduced, feed digestibility is effectively improved.

A kind of above-mentioned preparation method for preventing hepatic feed addictive, includes the following steps:

(1) by mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5- 5kg, enzyme preparation 0.2-20%, silica 0.1-3%, maltodextrin 20-37% and starch 10-20% are crushed, and are sieved, and are mixed , mixture A is obtained；

(2) the mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

It further explains, the mesh number of the sieving is 24-80 mesh.According to demand prepared by technique, the present invention is to through powder The requirement of the not clear specification of the partial size of mixed component after broken, as long as component fineness meets the general requirement of feed addictive i.e. Can, the fineness that the mixture thus crushed is within the scope of 24-80 mesh reaches preparation and requires, and explanation is not developed in details here.

It further explains, the vitamin is vitamin A, vitamin B1, vitamin B2, niacinamide, vitamin B6, dimension One or more combinations of raw element E, vitamin C, calcium pantothenate, folic acid and vitamin B12；The enzyme preparation be neutral proteinase, One or more combinations of cellulase, phytase, lipase, amylase, zytase and dextranase.

It further explains, above-mentioned prevents that hepatic feed addictive is cultivated for aquatic biological.By prevention and treatment liver The feed addictive of disease is widely used in aquatic biological cultivation, improves the anti-hepatopathy ability and vitality of aquatic biological, reduces and raises Expect the cost fed, improves the output value of aquatic biological.

It is the characteristics of present invention is according to the hepato-enteric circulation of aquatic livestock, theoretical based on liver sausage one, to bile acid, turmeric Each ingredient progress scientific compatibility of element, L-carnitine, multi-vitamins and complex enzyme formulation, prepared curcumin can effectively be prevented It harnesses the river and produces the liver diseases such as animal tallow liver, liver and gall syndrome, improve survival rate, the digestion of aquatic livestock nutriment is promoted to inhale It receives, promotes animal growth rate, shorten the culture-cycle, reduce feed coefficient, be suitble to the production market demand of feed addictive；It should Feed addictive is environmentally protective, can be used for large-scale industrial production, for feed palatability without any adverse effect, it has There are safety, specificity, noresidue and without side-effects.

The preparation method operating method for preventing hepatic feed addictive of the invention is simple, and raw material sources used are steady Fixed, low in cost, process controllability is strong, can produce and above-mentioned prevent hepatic feed addictive.

Specific embodiment

The present invention program is described in detail below by some specific embodiments.Those skilled in the art should manage Solution, it is following to be embodied as preferred embodiment, only the present invention program is explained, and wherein might have to known skill The appropriate omission of art, those skilled in the art should understand the present invention in conjunction with the explanation of well-known technique and embodiment.

One kind preventing hepatic feed addictive, is calculated by mass percentage, comprising: bile acid 1-20%, curcumin 0.1- 15%, L-carnitine 0.1-15%, multi-vitamins 0.5- 5%, complex enzyme formulation 0.2-20% and auxiliary material 30.1-60%.

It is existing insufficient in the process to be directed to existing aquatic, feed addictive of the invention is used with bile acid, ginger A variety of Hepatoprotective cholagogue drugs as main component such as flavine, L-carnitine, multi-vitamins and complex enzyme formulation compound, no It is both safe and effective containing any poisonous and harmful element, the fatty infiltration of liver of aquatic livestock can be prevented, its liver function is enhanced, The absorption efficiency of feed is improved, promotes aquatic livestock growth and improves its survival rate.

It further explains, bile acid and L-carnitine play an important role in fat metabolism, can effectively prevent to support It grows animal nutritional disease in the liver and gallbladder and improves aerobic oxidation and anti-stress ability；Curcumin can be removed in animal body with liver protection, cholagogue Free radical, protect liver, improve liver function, promote bile secretion and diminish inflammation inflammation；Complex enzyme formulation effectively facilitates water Digestion and absorption of the animal to nutriment are produced, the generation of intestinal endotoxin is reduced, to reduce enteron aisle during hepato-enteric circulation Endotoxin absorbs the probability of damage liver, effectively improves feed digestibility；Multi-vitamins then can be enhanced animal immune function, Anti-stress ability and production performance；Above-mentioned each substance rational proportion, synergistic effect, can effectively restore the hepar damnification of aquatic livestock And immune function is improved, promote the autoimmunity and premunition of aquatic livestock, to reach aquatic livestock normal growth, improves The purpose of economic benefit of aquaculture.

Curcumin is a kind of natural yellow extracted from the rhizome of Zingiber curcuma turmeric, curcuma zedoary, Radix Curcumae etc. Acid phenolic substances is the most important active constituent that turmeric plays pharmacological action.On the one hand curcumin can reduce high-fat It is especially more significant to reduce the effect of triglycerides with the content of hepatic cholesterol and triglycerides；And curcumin may lead to It crosses and promotes fat to the conversion of carbohydrate and inhibit cholesterol biosynthesis and there is effect for reducing blood fat；On the other hand, curcumin Can be by promoting the metabolism of liver and adrenal gland to low-density lipoprotein and lipoprotein, increase gall-bladder drains low-density lipoprotein, Inhibit intake of the spleen to low-density lipoprotein, reduces the content of low-density lipoprotein and lipoprotein in blood, the work with reducing blood lipid With；And curcumin can protect liver cell, increase the growth and secretion of bile, and can promote gallbladder contraction.

L-carnitine is the substance of one of fat metabolic process key, fatty acid can be promoted to enter mitochondrial oxidation It decomposes, promotes the conversion of fat.L-carnitine is the carrier for transporting fatty acid.Aquatic livestock in long-time strenuous exercise, The L-carnitine improves the oxidation rate of fat, reduces the consumption of glycogen, delay fatigue.

The multi-vitamins are supplemented, the necessary nutritional supplementation vitamin of the aquatic livestocks such as fish can improve fish body Nutritional status；Multi-vitamins itself have therapeutic effect simultaneously, can reinforce the disease resistance of fish body, and auxiliary removing toxic substances promotes liver The reparation of dirty damage and the regeneration of liver cell, promote physical recovery.

Vitamin A has the function of promoting aquatic livestock production, promotes the synthesis of mucopolysaccharide, maintain cell membrane and epithelium group The integrality knitted and normal permeability participate in constituting photoactive substance in cellula visualis, have emphatically to the photonasty for maintaining retina It acts on, therefore vitamin A is required to aquatic livestock immune system normal function is maintained；Vitamin C enhances immunity of organism Power plays the role of promoting the absorption of enteral iron, and for the poisoning of heavy metal ion and the removing toxic substances of drug poisoning, the subsidy of anaemia is controlled It treats；Vitamin E promotes aquatic livestock growth, and vitamin E is antioxidant important in animal body, can protect cell membrane and Asia Cell membrane prevents the generation of competent cell membrane phospholipid peroxide from Peroxidative damage, can increase the stability of meat and prolong It is long to save.The function of said vitamin is adding ingredient well known in the art, and performance is without burdensome explanation.

It further explains, the complex enzyme formulation is neutral proteinase, cellulase, phytase, lipase, starch One or more combinations of enzyme, zytase and dextranase.The complex enzyme formulation is exogenous enzymes, and addition exogenous enzymes effectively promote Digestion and absorption into aquatic livestock to nutriment, reduce the generation of intestinal endotoxin, thus during reducing hepato-enteric circulation Intestinal endotoxin absorbs the probability of damage liver, effectively improves feed digestibility, promotes growth of animals or poultry.

Specific mechanism is as follows:

1, neutral proteinase participates in the deficiency of the degradation of high molecular weight protein, the endogenous enzymic digestion secretion of supplement, improves protein raw materials Utilization rate；

2, cellulase can effectively improve cellulose, hemicellulose decomposes, and promote the dissolution of plant cell wall, make more to plant Object cellular content, which is dissolved, to be come out, and the digestion and absorption of animal gastrointestinal tract is conducive to；

3, phytase provides the utilization rate of phosphorus in feed, eliminates the anti-nutritional factors in feed, substitutes Phos, reduces animal excreta Just the content of middle phosphorus mitigates the pollution to environment；

4, lipase can promote the absorption of fat and albumen, reduce the chance of waste and diarrhea, promote fat-soluble nutrients element It absorbs, reduces pigment and add cost；

5, zytase can reduce the bracing and shape of mesh-shape hydrogel by the xylanolitic in feed at lesser segment At, be that waterpower declines with the generation of this decomposition, significantly reduce enteron aisle chyme viscosity, eliminate the anti-nutrition of xylan Effect；

6, amylase and dextranase act synergistically on starch, promote the digestion of starchy material in feed.

In conclusion the secretion of the complex enzyme formulation activation endogenous enzymes, supplements the deficiency of endogenous enzymes, each enzyme specificity enzyme Different macromolecular nutritional ingredients in prawn feed are solved, the digestive function of gut of shrimp has been effectively facilitated, to play raising growth Rate and digestibility, the effect for reducing feed coefficient.

Since the alimentary canal of fish and shrimp aquatic livestock is free of zytase, phytase and cellulase, amylase activity is low, And the complex enzyme formulation be made of one or more bioactive substances that can decompose feed nutrition strand it is micro Additive adds exogenous digestive ferment in feed, the strand of each nutrition composition or its digestion in degradable fishes and shrimps feed The composition of enzyme system in road promotes the digestion of protein, starch and fat, improves food utilization efficiency.

The silica is also known as river sand, as the carrier of feed addictive, the main WeiDongLi Capsule for increasing aquatic livestock, Help to digest, square is applied in poultry feed, while the feed addictive by adding the silica has preferably Mobility and anticaking capacity, convenient for the feeding of aquatic livestock.

The alphalise starch is pre-gelatinized starch again, facilitates the forming of particle and guarantees certain pellet hardness and durable Property, increase the stability of aquatic feeds in water, reduce the dust in process, increase caking property, avoids feed in water It is easy to loose, so that aquatic livestock ingests and prevent being scattered and being lost for nutriment.These are content known in this field, no It additionally repeats again.

(1) by mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5- 5%, enzyme preparation 0.2-20%, silica 0.1-3%, maltodextrin 20-37% and starch 10-20% are crushed, and sieving is mixed, Obtain mixture A；

The present invention is described in detail combined with specific embodiments below.

The Vitamin U that embodiment 1-5 is used is selected as multi-vitamins, and component is specially vitamin B1, vitamin B2, cigarette Amide, vitamin B6 and calcium pantothenate；Enzyme preparation is preferably complex enzyme formulation, component be specially neutral proteinase, cellulase and Amylase.

Embodiment 1:

Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin B1 0.3kg, vitamin B2 0.1kg, niacinamide 0.3kg, vitamin B6 0.1kg, calcium pantothenate 0.04kg, neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, two Silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains Mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

Embodiment 2:

Weigh bile acid 1kg, curcumin 15kg, L-carnitine 15kg, vitamin B1 0.1kg, vitamin B2 0.1kg, niacinamide 0.1kg, vitamin B6 0.1kg, calcium pantothenate 0.1kg, neutral proteinase 2kg, cellulase 1kg, amylase 6kg, silica 2.5kg, maltodextrin 37kg and α starch 20kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；It presses The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

Embodiment 3:

Weigh bile acid 15kg, curcumin 15kg, L-carnitine 0.1kg, vitamin B1 1kg, vitamin B2 1kg, niacinamide 1kg, vitamin B6 1kg, calcium pantothenate 1kg, neutral proteinase 4kg, cellulase 3kg, amylase 13kg, silica 3kg, Maltodextrin 31.9kg and α starch 10kg is crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；According to existing There is technique technology of preparing that the mixture A is pressed into agent, obtains preventing hepatic feed addictive.

Embodiment 4:

Weigh bile acid 20kg, curcumin 0.1kg, L-carnitine 15kg, vitamin B1 0.3kg, vitamin B2 0.3kg, cigarette Amide 0.4kg, vitamin B6 1kg, calcium pantothenate 0.4kg, neutral proteinase 4kg, cellulase 3kg, amylase 12.5kg, two Silica 3kg, maltodextrin 20kg and α starch 20kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

Embodiment 5:

Weigh bile acid 20kg, curcumin 15kg, L-carnitine 15kg, vitamin B1 0.6kg, vitamin B2 1kg, niacinamide 0.4kg, vitamin B6 0.6kg, calcium pantothenate 0.2kg, neutral proteinase 0.05kg, cellulase 0.05kg, amylase 0. 1kg, silica 3kg, maltodextrin 24kg and α starch 20kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains Mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

The vitamin that embodiment 6-9 is used for vitamin A, vitamin B1, vitamin B2, niacinamide, vitamin B6, One or more combinations of vitamin E, vitamin C, calcium pantothenate, folic acid and vitamin B12；The enzyme preparation used is neutrality One or more combinations of protease, cellulase, phytase, lipase, amylase, zytase and dextranase.

Embodiment 6:

Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin B1 0.3kg, neutral proteinase 4kg, cellulose Enzyme 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are crushed, and be sieved (mesh Number is 24-80 mesh), it is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, is obtained Prevent hepatic feed addictive.

Note: the vitamin in the product is single vitamin B1.

Embodiment 7:

Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin B1 0.3kg, niacinamide 0.3kg, neutral protein Enzyme 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are carried out It crushes, sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；The mixture A is pressed according to prior art technology of preparing Agent is made, obtains preventing hepatic feed addictive.

Note: the vitamin in the product is the multi-vitamins of vitamin B1 and niacinamide.

Embodiment 8:

Note: the vitamin in the product is the multi-vitamins of vitamin B1, vitamin B6 and niacinamide.

Embodiment 9:

Note: the enzyme preparation in the product is single neutral proteinase.

Embodiment 10:

Note: the enzyme preparation in the product is the complex enzyme formulation of neutral proteinase and cellulase.

The Vitamin U that comparative example 1-5 is used is selected as multi-vitamins, and component is specially vitamin B1, vitamin B2, niacinamide, vitamin B6 and calcium pantothenate；Enzyme preparation is preferably complex enzyme formulation, and component is specially neutral proteinase, cellulose Enzyme and amylase.

Comparative example 1:

Weigh curcumin 5kg, L-carnitine 3kg, vitamin B1 0.3kg, vitamin B2 0.1kg, niacinamide 0.3kg, dimension life Plain B6 0.1kg, calcium pantothenate 0.04kg, neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

Note: the product is without addition bile acid component.

Comparative example 2:

Weigh bile acid 20kg, L-carnitine 3kg, vitamin B1 0.3kg, vitamin B2 0.1kg, niacinamide 0.3kg, dimension life Plain B6 0.1kg, calcium pantothenate 0.04kg, neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed addictive.

Note: the product is without addition curcumin.

Comparative example 3:

Weigh bile acid 20kg, curcumin 5kg, vitamin B1 0.3kg, vitamin B2 0.1kg, niacinamide 0.3kg, vitamin B6 0.1kg, calcium pantothenate 0.04kg, neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, Maltodextrin 36.06kg and α starch 16kg is crushed, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；According to The mixture A is pressed into agent by prior art technology of preparing, obtains preventing hepatic feed addictive.

Note: the product is without addition L-carnitine.

Comparative example 4:

Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg are crushed, sieving (mesh number is 24-80 mesh), It is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains preventing hepatic feed Additive.

Note: the product is without addition multi-vitamins.

Comparative example 5:

Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin B1 0.3kg, vitamin B2 0.1kg, niacinamide 0.3kg, vitamin B6 0.1kg, calcium pantothenate 0.04kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg into Row crushes, and sieving (mesh number is 24-80 mesh) is mixed, obtains mixture A；According to prior art technology of preparing the mixture A It is pressed into agent, obtains preventing hepatic feed addictive.

Note: the product is without addition complex enzyme formulation.

Comparative example 6:

Weigh silica 0.1kg, maltodextrin 36.06kg and α starch 16kg is crushed, sieving (mesh number be 24-80 mesh), It is mixed, obtains mixture A；The mixture A is pressed into agent according to prior art technology of preparing, obtains feed addictive.

Note: the product is without addition bile acid, curcumin, L-carnitine, multi-vitamins and complex enzyme formulation.

Effect proof property test is carried out for the feed addictive of each embodiment and comparative example preparation.

Penaeus Vannmei 600 are chosen, is divided into two groups, every group 300, feed prepared by each embodiment and comparative example is added Agent is added to carry out the feeding that feeds intake by the dosage of 5g/kg.It is carried out the 30th day in experiment, observation each group prawn sign, record growth conditions, Liver color state simultaneously scores (standards of grading, which correspond to table, see the table below 1), while weighing to Penaeus Vannmei, records and calculates The indexs such as survival rate, feed coefficient, obtained experimental result see the table below 2- table 4.

1 standards of grading of table correspond to table

2 embodiment 1-5 growth-promoting effect of table

As seen from the results in Table 2:

(1) component of embodiment 1 can be seen that with embodiment 2-5 comparison respectively by embodiment 1 and dosage is optimum formula, The survival rate of Penaeus Vannmei is higher than the said components of embodiment 2-5, and feed coefficient wants small, growth conditions and liver state Scoring score want high, other components numerical value corresponding in value range has corresponding variation, all has preferable prevention and treatment liver The effect of disease.

3 embodiment 6-10 growth-promoting effect of table

As seen from the results in Table 3:

(1) being compared respectively with embodiment 6-8 by embodiment 1 can be seen that when other components are centainly constant, using single The feed addictive of the compound of vitamin or two kinds of vitamin preparation, the multi-vitamins than implementing 1 used component The survival rate of the fed Penaeus Vannmei of additive want low, feed coefficient is big, the scoring point of growth conditions and liver state Number wants low；

(2) it is compared with embodiment 9-10 as can be seen that when other components are centainly constant respectively by embodiment 1, use is single Enzyme preparation or two kinds of enzyme preparations compound preparation feed addictive, the equal complex enzyme systems than implementing 1 used component The survival rate of the fed Penaeus Vannmei of feed addictive of agent preparation wants low, and feed coefficient is big, growth conditions and liver shape The scoring score of state wants low.

(3) by above-mentioned provable, Vitamin U is selected as implementing 1 multi-vitamins, and enzyme preparation is preferably embodiment 1 Complex enzyme formulation, prepared by feed addictive it is better than single vitamin or the feeding effect of enzyme preparation.

4 comparative example 1-6 growth-promoting effect of table

From the result of table 4 and table 2:

(1) it is compared with comparative example 1-5 as can be seen that when other components are centainly constant, is not added respectively by embodiment 1 Bile acid, curcumin, L-carnitine, multi-vitamins and complex enzyme formulation a certain component therein, Penaeus Vannmei survive Rate all adds the low of said components than embodiment 1, and feed coefficient is big, and the scoring score of growth conditions and liver state is wanted It is low；

(2) by embodiment 1 and the comparison of comparative example 6 as can be seen that addition bile acid, curcumin, L-carnitine, compound dimension Feed prepared by raw element and complex enzyme formulation, the survival rate for the Penaeus Vannmei fed and does not add any component Want high, feed coefficient wants low, represents that feed for nursing is fewer, and the scoring score of growth conditions and liver state wants high.

In conclusion the present invention with bile acid, curcumin, L-carnitine, multi-vitamins and complex enzyme formulation it is each at Divide and carry out scientific compatibility, the compound effect of the curcumin and other components of prepared component can effectively prevent aquatic livestock fat The liver diseases such as liver, liver and gall syndrome improve survival rate, reduce feed coefficient, and the digestion of aquatic livestock nutriment is promoted to inhale It receives, promotes animal growth rate, improve the economic benefit of cultivation.

The above description of the embodiments is intended to facilitate ordinary skill in the art to understand and use the invention. Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general Principle is applied in other embodiments without having to go through creative labor.Therefore, the present invention is not limited to the above embodiments, ability Field technique personnel announcement according to the present invention, improvement and modification made without departing from the scope of the present invention all should be of the invention Within protection scope.

Claims

1. one kind prevents hepatic feed addictive, which is characterized in that be calculated by mass percentage, comprising: bile acid 1-20%, Curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5- 5%, enzyme preparation 0.2-20% and auxiliary material 30.1-60%.

2. according to claim 1 prevent hepatic feed addictive, which is characterized in that the vitamin be vitamin A, Vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin E, vitamin C, calcium pantothenate, folic acid and vitamin B12 one Kind or multiple combinations.

3. according to claim 1 prevent hepatic feed addictive, which is characterized in that the enzyme preparation is neutral protein One or more combinations of enzyme, cellulase, phytase, lipase, amylase, zytase and dextranase.

4. according to claim 1 prevent hepatic feed addictive, which is characterized in that the auxiliary material be silica, Maltodextrin and starch, the mass percent for accounting for the prevention and treatment hepatopathy feed addictive are respectively as follows: silica 0.1-3%；Wheat Bud dextrin 20-37%；Starch 10-20%.

5. according to claim 1 prevent hepatic feed addictive, which is characterized in that the vitamin is by vitamin The multi-vitamins that B1, vitamin B2, niacinamide, vitamin B6 and calcium pantothenate form.

6. according to claim 1 prevent hepatic feed addictive, which is characterized in that the enzyme preparation is by neutral egg The complex enzyme formulation of white enzyme, cellulase and amylase composition.

7. a kind of preparation method for preventing hepatic feed addictive, which comprises the steps of:

(2) the mixture A is pressed into agent, obtains preventing hepatic feed addictive.

8. the preparation method according to claim 7 for preventing hepatic feed addictive, which is characterized in that the sieving Mesh number is 24-80 mesh.

9. the preparation method according to claim 7 for preventing hepatic feed addictive, which is characterized in that the vitamin For vitamin A, vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin E, vitamin C, calcium pantothenate, folic acid and Wei Sheng One or more combinations of plain B12；The enzyme preparation is neutral proteinase, cellulase, phytase, lipase, amylase, wood One or more combinations of dextranase and dextranase.

10. by preventing that hepatic feed addictive is used for aquatic biological cultivation as described in any one of claim 1-6.