CN108813163A - A kind of feed addictive and preparation method thereof for treating fish hepatopathy - Google Patents

A kind of feed addictive and preparation method thereof for treating fish hepatopathy Download PDF

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Publication number
CN108813163A
CN108813163A CN201810756337.3A CN201810756337A CN108813163A CN 108813163 A CN108813163 A CN 108813163A CN 201810756337 A CN201810756337 A CN 201810756337A CN 108813163 A CN108813163 A CN 108813163A
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hepatopathy
feed addictive
fish
liver
preparation
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卢光贤
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Foshan Gaoming Science And Technology Information Consulting Service Department
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Foshan Gaoming Science And Technology Information Consulting Service Department
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Insects & Arthropods (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

The invention discloses the feed addictives for the treatment of fish hepatopathy, are calculated by mass percentage, including：Bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, ammonium glycyrrhetate 5-8%, glycine 6-10%, Lamivudine 2-8%, Lovastatin 4-10%, enzyme preparation 0.2-20% and auxiliary material 30.1-60%.Drug prepared by the present invention can effectively prevent the liver diseases such as aquatic livestock fatty liver, liver and gall syndrome, improve survival rate, promote the digestion and absorption of aquatic livestock nutriment, promote animal growth rate, shorten the culture-cycle, reduce feed coefficient, is suitble to the production market demand of feed addictive；The preparation method operating method of the feed addictive for the treatment of fish hepatopathy of the invention is simple, and raw material sources used are stablized, and low in cost, process controllability is strong, can produce the feed addictive of above-mentioned treatment fish hepatopathy.

Description

A kind of feed addictive and preparation method thereof for treating fish hepatopathy
Technical field
The present invention relates to a kind of technical fields of aquatic products feed additives more particularly to a kind of feed for treating fish hepatopathy to add Add agent and preparation method thereof.
Background technique
Liver is an organ based on metabolic function, is generating bile, removing toxic substances, blood coagulation, immune, generation energy, water With very important effect is played in the adjusting of electrolyte, up to 1500 kinds or more of the chemical reaction occurred in liver, because This is also considered as one huge " chemical plant ".This is because its unique morphology and history structure and Characteristics of Chemical Constituents, are assigned The complicated and diversified biochemical function of liver is given.
Firstly, the blood supply of liver is very rich, there is arteria hepatica and pylic double blood supply, so that liver is thin Born of the same parents can not only obtain sufficient oxygen and metabolin from arteria hepatica, but also the largely various battalion by intestinal absorption can be obtained from portal vein Substance is supported, these are all that the various metabolisms of liver progress have established material base.Secondly, there are vena hepaticas and biliary tract system for liver It unites dual output channel.Vena hepatica is connected with body circulation, and the metabolite in liver can be transported to its hetero-organization and utilize or be discharged In vitro；Biliary system is communicated with enteron aisle, the bile of hepatic secretion is discharged into enteron aisle, and some metabolic wastes are discharged simultaneously.
Based on these above-mentioned features, liver is not only in the metabolisms such as sugar, lipid, protein, vitamin, hormone Central Position, but also the physiological function with bioconversion, secretion and excretion etc., therefore, nourishing and protecting liver just seems outstanding It is important.In view of the dual channel system of liver, the performance of metabolic function is highly dependent upon enteron aisle, and hepato-enteric circulation is wherein heavy The ring wanted.
Bile acid in bile is the essential substance of lipid food digestion, and primary bile acid flows into enteron aisle with bile, While promoting lipid to digest and assimilate, become secondary bile acid by bacterial action in enteron aisle, the bile acid of enteral there are about 95% by intestinal wall reabsorption (including active reabsorption and passive reabsorption), and re-absorbed bile acid trans-portal vein returns liver, warp After liver cell processing, it is discharged into enteron aisle through biliary tract again together with newly synthesized bile acid, this process is known as the hepato-enteric circulation of bile acid.
The meaning of hepato-enteric circulation is to improve bile availability, the digestion and absorption such as promotion lipid, while can also remove intestines Road endotoxin safeguards intestinal health.When compromised liver function, enteron aisle is possible to be contaminated；Conversely, intestinal flora loses It adjusts, is likely to that liver can be poisoned.Therefore, nourishing and protecting liver must have the integrated idea of liver sausage health care, and intestines two are protected in nourishing the liver Person is inseparable.
Under the conditions of intensive high-density breeding, breeding environment deteriorates, largely using anti-in antibiotic medicine, feedstuff Presence of trophic factors etc. all can cause to damage to cultivated animals liver and gallbladder, cause to occur becoming main with liver and bladder disease in current cultivation Want the disease in the liver and gallbladder syndrome of feature.Hepatic disease causes liver function that obstacle occurs, and influences being absorbed and utilized for nutriment, exempts from Epidemic disease function reduces, anti-stress ability and premunition decline, and then influences aquatic livestock normal growth, and culture efficiency is caused to be damaged Evil.
Summary of the invention
It is an object of the invention to aiming at the deficiencies in the prior art, provide a kind of liver protecting used for aquiculture Feed addictive, the feed addictive can be effectively improved hepato-enteric circulation, effectively prevent animal hepatopathy, promote the life of aquatic livestock Order power and health degree；The preparation method of the feed addictive, preparation process is easy, low production cost, promotes aquatic livestock rouge Fat metabolism reduces the generation of aquatic products fatty liver, promotes aquatic health growth.
For this purpose, the present invention uses following technical scheme：
A kind of feed addictive for treating fish hepatopathy, is calculated by mass percentage, including：Bile acid 1-20%, curcumin 0.1- 15%, L-carnitine 0.1-15%, ammonium glycyrrhetate 5-8%, glycine 6-10%, Lamivudine 2-8%, Lovastatin 4-10%, enzyme system Agent 0.2-20% and auxiliary material 30.1-60%.
Feed addictive of the invention can prevent the fatty infiltration of liver of aquatic livestock, enhance its liver function, improve and raise The absorption efficiency of material promotes aquatic livestock growth and improves its survival rate.
It further explains, bile acid and L-carnitine play an important role in fat metabolism, can effectively prevent to support Grow animal nutritional disease in the liver and gallbladder；Curcumin can remove the intracorporal free radical of animal with liver protection, cholagogue, protect liver, improve liver Dirty function promotes bile secretion and the inflammation that diminishes inflammation；Complex enzyme formulation effectively facilitate aquatic livestock to the digestion of nutriment and It absorbs, reduces the generation of intestinal endotoxin, so that the probability that intestinal endotoxin during hepato-enteric circulation absorbs damage liver is reduced, Effectively improve feed digestibility；Animal immune function, anti-stress ability and production performance then can be enhanced in multi-vitamins.
Ammonium glycyrrhetate, glycine have anti-inflammatory, protection liver plasma membrane, immunological regulation, antiviral anti-hepatic fibrosis, inhibit liver Many-sided effect such as cell carcinogenesis, regulating cell apoptosis, anticomplement.ALT, AST are synchronous to improve, and has apparent drop enzyme and removing jaundice to make With.It is significant to treat hepatitis b curative effect；Lovastatin competitively inhibits the speed limit during cholesterol biosynthesis in vivo Enzyme HMG-CoA reductase reduces the synthesis of cholesterol, also increases LDL receptor synthesis, mainly As a result site of action reduces cholesterolemia and low-density lipoprotein cholesterol level in liver.
Above-mentioned each substance rational proportion, synergistic effect can effectively restore the hepar damnification of aquatic livestock and improve immune function Can, promote the autoimmunity and premunition of aquatic livestock, to reach aquatic livestock normal growth, improves economic benefit of aquaculture Purpose.
It further explains, the complex enzyme formulation is neutral proteinase, cellulase, phytase, lipase, starch One or more combinations of enzyme, zytase and dextranase.
The complex enzyme formulation is exogenous enzymes, and addition exogenous enzymes effectively facilitate digestion and suction of the aquatic livestock to nutriment It receives, reduces the generation of intestinal endotoxin, to reduce the probability that intestinal endotoxin during hepato-enteric circulation absorbs damage liver, have Effect improves feed digestibility, promotes growth of animals or poultry.
It further explains, the auxiliary material is silica, maltodextrin and starch, accounts for the prevention and treatment hepatopathy feed and adds The mass percent for adding agent is respectively：Silica 0.1-3%；Maltodextrin 20-37%；Starch 10-20%.
The higher river sand of silicone content can be used in silica, and as the carrier of feed addictive, the main aquatic products that increases is moved The WeiDongLi Capsule of object helps to digest, and square is applied in poultry feed, while the feed addition by adding the silica Agent has preferable mobility and anticaking capacity, convenient for the feeding of aquatic livestock.
Malt lake essence is to have with preferable emulsification and thickening effect and promote formed product and inhibit well The effect of product institutional framework, moldability can be good, can prevent deformation of products from can improve product appearance again, easily be absorbed, extensively Basic auxiliary material applied to feed product.
The starch is preferably alphalise starch, and is pre-gelatinized starch, facilitates the forming of particle and guarantees certain particle Hardness and durability increase the stability of aquatic feeds in water, reduce the dust in process, increase caking property, avoid Feed is easy to loosely in water, so that aquatic livestock ingests and prevent being scattered and being lost for nutriment.These are this field Known content, no longer additionally repeats.
Preferably, the enzyme preparation is the complex enzyme formulation being made of neutral proteinase, cellulase and amylase.Pass through Protein digestibility is greatly improved after neutral proteinase is added, after amylase is added, the digestibility of starch, cellulose can be improved Enzyme can activate the secretion of endogenous enzymes, supplement the deficiency of endogenous enzymes, and be adjusted to endogenous enzymes, guarantee that animal normally digests suction Function is received, diseases prevention and somatotrophic is played the role of.
Using above-mentioned three kinds of substances as the complex enzyme formulation, it is obviously promoted digestion of the aquatic livestock to nutriment And absorption, the generation of intestinal endotoxin is reduced, feed digestibility is effectively improved.
A kind of preparation method of the feed addictive of above-mentioned treatment fish hepatopathy, includes the following steps：
（1）By mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, ammonium glycyrrhetate 5- 8%, glycine 6-10%, Lamivudine 2-8%, Lovastatin 4-10%, enzyme preparation 0.2-20% and auxiliary material 30.1-60% carry out powder Broken, sieving is mixed, obtains mixture A；
（2）The mixture A is pressed into agent according to prior art technology of preparing, the feed addition for the fish hepatopathy that obtains medical treatment Agent.
It further explains, the mesh number of the sieving is 24-80 mesh.According to demand prepared by technique, the present invention is to through powder The requirement of the not clear specification of the partial size of mixed component after broken, as long as component fineness meets the general requirement of feed addictive i.e. Can, the fineness that the mixture thus crushed is within the scope of 24-80 mesh reaches preparation and requires, and explanation is not developed in details here.
It further explains, the feed addictive of above-mentioned treatment fish hepatopathy is cultivated for aquatic biological.It is controlled by The feed addictive for treating fish hepatopathy is widely used in aquatic biological cultivation, improves the anti-hepatopathy ability and life of aquatic biological Power reduces the cost of forage feed, improves the output value of aquatic biological.
It is the characteristics of present invention is according to the hepato-enteric circulation of aquatic livestock, theoretical based on liver sausage one, to bile acid, turmeric Element, L-carnitine, ammonium glycyrrhetate, glycine, Lamivudine, Lovastatin and complex enzyme formulation each ingredient carry out science and match 5, prepared curcumin can effectively prevent the liver diseases such as aquatic livestock fatty liver, liver and gall syndrome, improve survival rate, promote Water inlet produces the digestion and absorption of Animal nutrition substance, promotes animal growth rate, shortens the culture-cycle, reduces feed coefficient, is suitble to The production market demand of feed addictive；The feed addictive is environmentally protective, can be used for large-scale industrial production, for feed Palatability without any adverse effect.
Simple, the used raw material sources of the preparation method operating method of the feed addictive for the treatment of fish hepatopathy of the invention Stablize, low in cost, process controllability is strong, can produce the feed addictive of above-mentioned treatment fish hepatopathy.
Specific embodiment
The present invention program is described in detail below by some specific embodiments.Those skilled in the art should manage Solution, it is following to be embodied as preferred embodiment, only the present invention program is explained, and wherein might have to known skill The appropriate omission of art, those skilled in the art should understand the present invention in conjunction with the explanation of well-known technique and embodiment.
Embodiment 1：
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, ammonium glycyrrhetate 5kg, glycine 6kg, Lamivudine 2kg, Lip river Cut down statin 4kg neutral proteinase 4kg, cellulase 2.5kg, amylase 12.5kg, silica 0.1kg, maltodextrin 36.06kg and α starch 16kg is crushed, sieving（Mesh number is 24-80 mesh）, it is mixed, obtains mixture A；According to prior art The mixture A is pressed into agent by technology of preparing, the feed addictive for the fish hepatopathy that obtains medical treatment.
Embodiment 2：
Weigh bile acid 1kg, curcumin 15kg, L-carnitine 15kg, ammonium glycyrrhetate 6kg, glycine 7kg, Lamivudine 6kg, Lovastatin 5kg, neutral proteinase 2kg, cellulase 1kg, amylase 6kg, silica 2.5kg, maltodextrin 37kg and α Starch 20kg is crushed, sieving（Mesh number is 24-80 mesh）, it is mixed, obtains mixture A；According to prior art technology of preparing handle The mixture A is pressed into agent, the feed addictive for the fish hepatopathy that obtains medical treatment.
Embodiment 3：
Weigh bile acid 15kg, curcumin 15kg, L-carnitine 0.1kg, ammonium glycyrrhetate 8kg, glycine 10kg, Lamivudine 8kg, Lovastatin 10kg, neutral proteinase 4kg, cellulase 3kg, amylase 13kg, silica 3kg, maltodextrin 31.9kg and α starch 10kg is crushed, sieving（Mesh number is 24-80 mesh）, it is mixed, obtains mixture A；According to prior art system The mixture A is pressed into agent by standby technology, the feed addictive for the fish hepatopathy that obtains medical treatment.
The above description of the embodiments is intended to facilitate ordinary skill in the art to understand and use the invention. Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general Principle is applied in other embodiments without having to go through creative labor.Therefore, the present invention is not limited to the above embodiments, ability Field technique personnel announcement according to the present invention, improvement and modification made without departing from the scope of the present invention all should be of the invention Within protection scope.

Claims (5)

1. a kind of feed addictive for treating fish hepatopathy, which is characterized in that it is calculated by mass percentage, including：Bile acid 1- 20%, curcumin 0.1-15%, L-carnitine 0.1-15%, ammonium glycyrrhetate 5-8%, glycine 6-10%, Lamivudine 2-8%, Lip river are cut down Statin 4-10%, enzyme preparation 0.2-20% and auxiliary material 30.1-60%；
The enzyme preparation is neutral proteinase, cellulase, phytase, lipase, amylase, zytase and dextranase One or more combinations；
The auxiliary material is silica, maltodextrin and starch, and the mass percent for accounting for the feed addictive is respectively：Two Silica 0.1-3%；Maltodextrin 20-37%；Starch 10-20%.
2. the feed addictive for the treatment of fish hepatopathy according to claim 1, which is characterized in that the enzyme preparation is in Property protease, cellulase and amylase composition complex enzyme formulation.
3. a kind of preparation method for the feed addictive for treating fish hepatopathy, which is characterized in that include the following steps：
（1）By mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, ammonium glycyrrhetate 5- 8%, glycine 6-10%, Lamivudine 2-8%, Lovastatin 4-10%, enzyme preparation 0.2-20%, silica 0.1-3%, malt paste Smart 20-37% and starch 10-20% are crushed, and sieving is mixed, obtains mixture A；
（2）The mixture A is pressed into agent, the feed addictive for the fish hepatopathy that obtains medical treatment.
4. the preparation method of the feed addictive for the treatment of fish hepatopathy according to claim 3, which is characterized in that the mistake The mesh number of sieve is 24-80 mesh.
5. the feed addictive of the treatment fish hepatopathy as described in any one of claim 1-2 is used to aquatic biological to support It grows.
CN201810756337.3A 2018-07-12 2018-07-12 A kind of feed addictive and preparation method thereof for treating fish hepatopathy Withdrawn CN108813163A (en)

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Application Number Priority Date Filing Date Title
CN201810756337.3A CN108813163A (en) 2018-07-12 2018-07-12 A kind of feed addictive and preparation method thereof for treating fish hepatopathy

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Application publication date: 20181116