CN106360115A - Feed additive for preventing and treating liver diseases and preparation method of same - Google Patents
Feed additive for preventing and treating liver diseases and preparation method of same Download PDFInfo
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- CN106360115A CN106360115A CN201610729670.6A CN201610729670A CN106360115A CN 106360115 A CN106360115 A CN 106360115A CN 201610729670 A CN201610729670 A CN 201610729670A CN 106360115 A CN106360115 A CN 106360115A
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Abstract
The invention discloses a feed additive for preventing and treating liver diseases, which includes, by mass, 1-20% of bile acid, 0.1-15% of curcumin, 0.1-15% of L-carnitine, 0.5-5% of vitamins, 0.2-20% of an enzyme preparation and 30.1-60% of an auxiliary material. In the invention, the bile acid, the curcumin, the L-carnitine, the compound vitamins and the compound enzyme preparation are scientifically combined, so that the feed additive can effectively prevent and treat liver diseases, such as fatty liver, liver and gall syndrome and the like of aquatic animals, improves survival rate, improves digestion and absorption of nutrients by the aquatic animals, accelerates growth of the animals, reduces breeding period, reduces food coefficient and is suitable for production and market demands of feed additives. A preparation method of the feed additive is simple in processes and employs raw materials being stable in sources and low in cost and has strong process controllability, and is used for preparing the feed additive for preventing and treating the liver diseases.
Description
Technical field
The present invention relates to a kind of technical field of Aquatic product feed additives, more particularly, to a kind of anti-hepatic feed additive
And preparation method thereof.
Background technology
Liver is an organ based on metabolic function, is generating bile, removing toxic substances, blood coagulation, immunity, is producing energy, water
With all play very important effect in the regulation of electrolyte, in liver occur up to more than 1500 kinds of chemical reaction, because
This is also considered as huge " chemical plant ".This is due to its unique morphology and history structure and Characteristics of Chemical Constituents, assigns
Give the complicated and diversified biochemical function of liver.
First, the blood supply of liver is very abundant, has Hepatic artery and pylic double blood supply so that liver is thin
Born of the same parents both can obtain oxygen and the metabolite of abundance from Hepatic artery, can obtain a large amount of various battalion by intestinal absorption from portal vein again
Foster material, these are all that liver carries out various substance metabolismes and established material base.Secondly, there is hepatic vein and biliary tract system in liver
Unite dual output channel.Hepatic vein is connected with body circulation, the metabolite in liver can be transported its hetero-organization and utilize or discharge
In vitro；Biliary system is communicated with intestinal, and the bile of hepatic secretion is entered intestinal, and discharges some metabolic wastes simultaneously.
Based on these features above-mentioned, liver is not only in the substance metabolismes such as sugar, lipid, protein, vitamin, hormone
Central Position, but also there is the physiological function of the aspects such as bioconversion, secretion and excretion, therefore, nourishing and protecting liver just seems outstanding
For important.In view of the dual channel system of liver, the performance of its metabolic function is highly dependent upon intestinal, and hepato-enteric circulation is wherein to weigh
The ring wanted.
Bile acid in bile is the requisite material of lipid food digestion, and primary bile acid flows into intestinal with bile,
While promoting lipid to digest and assimilate, it is changed into secondary bile acid by bacterial action in intestinal, the bile acid of enteral there are about
95% by intestinal wall reabsorption (including active reabsorption and passive reabsorption), and re-absorbed bile acid trans-portal vein returns liver,
After processing through hepatocyte, enter intestinal through biliary tract again together with the bile acid of new synthesis, the liver sausage that this process is referred to as bile acid follows
Ring.
The meaning of hepato-enteric circulation is to improve bile availability, promotes lipid etc. to digest and assimilate, can also remove intestinal simultaneously
Road endotoxin, safeguards intestinal health.When compromised liver function, intestinal is possible to be contaminated；Conversely, intestinal microbial population loses
Adjust, be likely to poison liver.Therefore, nourishing and protecting liver it is necessary to have liver sausage health care integration idea, nourishing the liver protect intestinal two
Person is inseparable.
Under the conditions of intensive high-density breeding, breeding environment deteriorates, in a large number using anti-in antibiotic medicine, feedstuff
Presence of trophic factors etc. all can cause to cultivated animals liver and gall to damage, and leads to occur in that in current cultivation based on liver-gallbladder disease change
Want the liver and gall diseases syndrome of feature.Hepatic lesions lead to liver function that obstacle, absorbing of impact nutrient substance occur, and exempt from
Epidemic disease function reduces, and anti-stress ability and premunition decline, and then affect aquatic animal normal growth, cause culture benefit to be damaged
Evil.
Content of the invention
Present invention aims to weak point of the prior art, provide a kind of hepatoprotective used for aquiculture
Feed additive, this feed additive can be effectively improved hepato-enteric circulation, effectively preventing and treating animal hepatopathy, the life of lifting aquatic animal
Life power and health degree；The preparation method of this feed additive, preparation process is easy, low production cost, promotes aquatic animal fat
Fat metabolism, reduces the generation of Aquatic product fatty liver, promotes aquatic health growth.
For reaching this purpose, the present invention employs the following technical solutions:
A kind of anti-hepatic feed additive, calculates, comprising: bile acid 1-20%, curcumin by mass percentage
0.1-15%, L-carnitine 0.1-15%, vitamin 0.5-5%, enzyme preparation 0.2-20% and adjuvant 30.1-60%.
Special instruction, Vitamin U elects compound vitamin as, and enzyme preparation is preferably compound enzymic preparation.It is directed to existing cultivation
Not enough present in Aquatic product process, the feed additive of the present invention adopts with bile acid, curcumin, L-carnitine, compound dimension life
Element and compound enzymic preparation etc. compound and form for multiple hepatic cholagogic medicines of main component, without any poisonous and harmful element, both
Safely and effectively, the fatty infiltration of liver of aquatic animal can be prevented, strengthen its liver function, improve absorption efficiency, the rush of feedstuff
Enter Aquatic product growth of animal and improve its survival rate.
Further illustrate, bile acid and L-carnitine play an important role in lipid metabolism, can effectively prevent to support
Grow animal nutritional liver and gall diseases；Curcumin can be removed the free radical in animal body, the liver protecting, improved liver with liver protection, function of gallbladder promoting
Dirty function, promotes bile secretion and the inflammation that diminishes inflammation；Compound enzymic preparation effectively facilitate aquatic animal to the digestion of nutrient substance and
Absorb, reduce the generation of intestinal endotoxin, thus reducing intestinal endotoxin during hepato-enteric circulation to absorb the probability damaging liver,
Effectively improve feed digestibility；Compound vitamin then can strengthen animal immune function, anti-stress ability and production performance.
Above-mentioned each material rational proportion, synergism, can effectively recover the hepar damnification of aquatic animal and improve immune work(
Can, promoting autoimmunity and the premunition of aquatic animal, thus reaching aquatic animal normal growth, improving fanning economics
Purpose.
Further illustrate, described compound vitamin is vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin
One or more combination of b6, vitamin e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12.
Supplement described compound vitamin, the necessary nutritional supplementation vitamin of the aquatic animal such as Fish, fish body can be improved
Nutritional statuses；Compound vitamin has therapeutical effect in itself simultaneously, can strengthen the resistances against diseases of fish body, auxiliary removing toxic substances, promotion liver
The reparation of dirty damage and hepatocellular regeneration, promote physical recovery.The function of said vitamin is well known in the art adding
Addition divides, and its performance does not carry out burdensome explanation.
Further illustrate, described compound enzymic preparation is neutral protease, cellulase, phytase, Digestive Enzyme, starch
One or more combination of enzyme, xylanase and glucanase.
Described compound enzymic preparation is exogenous enzyme, adds exogenous enzyme and effectively facilitates aquatic animal to the digestion of nutrient substance and suction
Receiving, reduce the generation of intestinal endotoxin, thus reducing intestinal endotoxin during hepato-enteric circulation to absorb the probability damaging liver, having
Effect improves feed digestibility, promotes growth of animals or poultry.
Further illustrate, described adjuvant is silicon dioxide, maltodextrin and starch, and it accounts for described hepatopathy feedstuff of preventing and treating and adds
Plus the mass percent of agent is respectively as follows: silicon dioxide 0.1-3%；Maltodextrin 20-37%；Starch 10-20%.
Silicon dioxide can be using the higher river sand of silicone content, and, as the carrier of feed additive, the main Aquatic product that increases moves for it
The gastric motility of thing, contributes to digesting, square is applied in poultry feed, and the feedstuff simultaneously passing through to add described silicon dioxide adds
Agent has preferable mobility and anticaking capacity, is easy to the feeding of aquatic animal.
Described Fructus Hordei Germinatus lake essence, for having preferable emulsification and thickening effect, has promotion formed product and suppresses well
The effect of product organizational structure, moulding property can be good, can prevent deformation of products from can improve product appearance again, easily be absorbed, extensively
It is applied to the basic adjuvant of feed product.
Described starch is preferably alphalise starch, is pre-gelatinized starch again, contributes to the shaping of granule and ensures certain granule
Hardness and durability, increase stability in water for the aquatic feeds, reduce the dust in the course of processing, increase caking property, it is to avoid
Feedstuff is easy to loose in water, so that aquatic animal is ingested and prevented being scattered and running off of nutrient substance.These are this area
Known content, no longer additionally repeats.
Preferably, described vitamin is made up of vitamin b1, vitamin b2, nicotiamide, vitamin b6 and calcium pantothenate
Compound vitamin.Vitamin b1 promotes the gastric digestion of aquatic animal；Vitamin b2 to the reduction of aquatic animal vivo oxidation and adjusts
Ganglion cell's breathing plays an important role, and can improve the utilization rate of feedstuff；Vitamin b2 is in b vitamin, aquatic animal relatively to be attached most importance to
Will, and it is difficult a kind of vitamin meeting, easily deficiency disease it should be noted that feeding in aquatic animal；Calcium pantothenate is coenzyme a
Ingredient, participates in carbohydrate, fat and protein metabolism, calcium pantothenate and vitamin b2 using there being substantial connection, one
Planting another kind of requirement when lacking increases；Additionally, calcium pantothenate is very unstable, easily it is damaged when mixing with feedstuff；Vitamin b6
It is the important vitamin of involved in sugar, fat and protein metabolism；Nicotiamide is the ingredient of coenzyme i and coenzyme ii, becomes perhaps
The coenzyme of many dehydrogenases.
Using above-mentioned five kinds of materials as described compound vitamin, significantly increase the nutritional statuses of aquatic animal, can add
The resistances against diseases of strong fish body, promote the reparation of hepar damnification and hepatocellular regeneration.
Preferably, described enzyme preparation is the compound enzymic preparation being made up of neutral protease, cellulase and amylase.Pass through
Greatly improve protein digestibility after adding neutral protease, after adding amylase, the digestibility of starch, cellulose can be improved
Enzyme can activate the secretion of endogenous enzymes, supplement the deficiency of endogenous enzymes, and endogenous enzymes are adjusted it is ensured that animal normally digests suction
Receive function, play diseases prevention and somatotrophic effect.
Using above-mentioned three kinds of materials as described compound enzymic preparation, it is obviously promoted the digestion to nutrient substance for the aquatic animal
And absorption, reduce the generation of intestinal endotoxin, effectively improve feed digestibility.
A kind of preparation method of above-mentioned anti-hepatic feed additive, comprises the steps:
(1) by mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, dimension life
Plain 0.5-5kg, enzyme preparation 0.2-20%, silicon dioxide 0.1-3%, maltodextrin 20-37% and starch 10-20% carry out powder
Broken, sieve, be mixed, obtain mixture a；
(2) according to existing process technology of preparing, described mixture a is pressed into agent, obtains anti-hepatic feedstuff and add
Agent.
Further illustrate, the described mesh number sieved is 24-80 mesh.According to the demand of technique preparation, the present invention is to through powder
The particle diameter of the blending ingredients after broken does not have the requirement of clear and definite specification, as long as the general requirement that component fineness meets feed additive is
Can, the fineness that the mixture thus pulverized is in the range of 24-80 mesh reaches preparation and requires, and is not developed in details in explanation here.
Further illustrate, described vitamin is vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin b6, dimension
One or more combination of raw element e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12；Described enzyme preparation be neutral protease,
One or more combination of cellulase, phytase, Digestive Enzyme, amylase, xylanase and glucanase.
Further illustrate, above-mentioned anti-hepatic feed additive is used for aquatic biological and cultivates.By anti-treating the liver
The feed additive of disease is widely used in aquatic biological cultivation, improves anti-hepatopathy ability and the vitality of aquatic biological, and reduction is raised
The cost that material is fed, improves the output value of aquatic biological.
The present invention according to the feature of the hepato-enteric circulation of aquatic animal, based on liver sausage one theoretical, to bile acid, Rhizoma Curcumae Longae
Each composition of element, L-carnitine, compound vitamin and compound enzymic preparation carries out scientific compatibility, and prepared curcumin can be effectively anti-
Control the hepatic disease such as Aquatic product Animal fat liver, liver and gallbladder syndrome, improve survival rate, promote the digestion of aquatic animal nutrient substance to inhale
Receive, lift animal growth rate, Shortening culturing period, reduce feed coefficient, the production market demand of suitable feed additive；Should
Feed additive environmental protection, can be used for large-scale industrial production, and for the no any harmful effect of palatability of feedstuff, it has
There are safety, specificity, noresidue and have no side effect.
The preparation method operational approach of the anti-hepatic feed additive of the present invention is simple, and raw material sources used are steady
Fixed, with low cost, process controllability is strong, you can produce above-mentioned anti-hepatic feed additive.
Specific embodiment
The present invention program is described in detail below by some specific embodiments.Those skilled in the art should manage
Solution, following be embodied as preferred embodiment, it only explains to the present invention program, and wherein might have to known skill
The suitable omission of art, those skilled in the art should understand to the present invention in conjunction with the explanation of known technology and embodiment.
A kind of anti-hepatic feed additive, calculates, comprising: bile acid 1-20%, curcumin by mass percentage
0.1-15%, L-carnitine 0.1-15%, compound vitamin 0.5-5%, compound enzymic preparation 0.2-20% and adjuvant 30.1-
60%.
It is directed to not enough present in existing aquatic process, the feed additive of the present invention adopts with bile acid, Rhizoma Zingiberis Recens
Flavin, L-carnitine, compound vitamin and compound enzymic preparation etc. be main component multiple hepatic cholagogic medicines compound form, no
Containing any poisonous and harmful element, both safe and effective, the fatty infiltration of liver of aquatic animal can be prevented, strengthen its liver function,
Improve the absorption efficiency of feedstuff, promote aquatic animal growth and improve its survival rate.
Further illustrate, bile acid and L-carnitine play an important role in lipid metabolism, can effectively prevent to support
Grow animal nutritional liver and gall diseases and improve aerobic oxidation and anti-stress ability；Curcumin can be removed in animal body with liver protection, function of gallbladder promoting
Free radical, the liver protecting, improve liver function, promote bile secretion and diminish inflammation inflammation；Compound enzymic preparation effectively facilitates water
Producing animal to the digestion of nutrient substance and absorption, reducing the generation of intestinal endotoxin, thus reducing intestinal during hepato-enteric circulation
Endotoxin absorbs the probability damaging liver, effectively improves feed digestibility；Compound vitamin then can strengthen animal immune function,
Anti-stress ability and production performance；Above-mentioned each material rational proportion, synergism, can effectively recover the hepar damnification of aquatic animal
And raising immunologic function, promoting autoimmunity and the premunition of aquatic animal, thus reaching aquatic animal normal growth, improving
The purpose of fanning economics.
Curcumin is a kind of natural yellow extracted from the rhizome of Zingiberaceae curcuma Rhizoma Curcumae Longae, Rhizoma Curcumae, Radix Curcumae etc.
Acid aldehydes matter, is the topmost active component that Rhizoma Curcumae Longae plays pharmacological action.Curcumin one side can reduce higher fatty acid
With the content of hepatic cholesterol and triglyceride, especially with reduce triglyceride effect more notable；And curcumin may lead to
Cross and promote fat to have effect for reducing blood fat to the conversion of carbohydrate and suppression cholesterol biosynthesis；On the other hand, curcumin
Gallbladder can be increased low density lipoprotein, LDL drained by promoting the metabolism to low density lipoprotein, LDL and lipoprotein of liver and adrenal gland,
The suppression picked-up to low density lipoprotein, LDL for the spleen, reduces the content of low density lipoprotein, LDL and lipoprotein in blood, has the work of blood fat reducing
With；And curcumin can protect hepatocyte, increase growth and the secretion of bile, and gallbladder contraction can be promoted.
L-carnitine is the crucial material of one of fat metabolic process, and fatty acid can be promoted to enter mitochondrial oxidation
Decompose, promote the conversion of fat.L-carnitine is the carrier of transhipment fatty acid.Aquatic animal in long-time strenuous exercise,
Described L-carnitine improves the oxidation rate of fat, decreases the consumption of glycogen, delay fatigue.
Further illustrate, described compound vitamin is vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin
One or more combination of b6, vitamin e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12.
Supplement described compound vitamin, the necessary nutritional supplementation vitamin of the aquatic animal such as Fish, fish body can be improved
Nutritional statuses；Compound vitamin has therapeutical effect in itself simultaneously, can strengthen the resistances against diseases of fish body, auxiliary removing toxic substances, promotion liver
The reparation of dirty damage and hepatocellular regeneration, promote physical recovery.
Vitamin a has the effect promoting aquatic animal to produce, and promotes the synthesis of mucopolysaccharide, maintains cell membrane and epithelium group
The integrity knitted and normal permeability, participate in constituting photoactive substance in optic cell, the photonasty maintaining retina are had emphatically
Act on, therefore vitamin a is necessary to maintaining aquatic animal immune system normal function；Vitamin c enhancing human body immunity
Power, plays the role of absorption, the poisoning for heavy metal ion and the removing toxic substances of drug intoxication promoting enteral ferrum, and the subsidy of anemia is controlled
Treat；Vitamin e promotes aquatic animal growth, and vitamin e is important antioxidant in animal body, can protect cell membrane and Asia
Cell membrane, from Peroxidative damage, prevents the generation of competent cell membrane phospholipid peroxide, can increase the stability of meat and prolong
Long preservation.The function of said vitamin is adding ingredient well known in the art, and its performance does not carry out burdensome explanation.
Further illustrate, described compound enzymic preparation is neutral protease, cellulase, phytase, Digestive Enzyme, starch
One or more combination of enzyme, xylanase and glucanase.Described compound enzymic preparation is exogenous enzyme, adds exogenous enzyme and effectively promotees
Enter aquatic animal to the digestion of nutrient substance and absorption, reduce the generation of intestinal endotoxin, thus during reducing hepato-enteric circulation
Intestinal endotoxin absorbs the probability damaging liver, effectively improves feed digestibility, promotes growth of animals or poultry.
Concrete mechanism is as follows:
1st, neutral protease participates in the degraded of high molecular weight protein, the deficiency of supplement endogenous enzymic digestion secretion, improves proteinogen
The utilization rate of material；
2nd, cellulase can effectively improve cellulose, hemicellulose decomposes, and promote the dissolving of plant cell wall, make more
Plant cell content be dissolved out, be conducive to digesting and assimilating of animal gastrointestinal tract；
3rd, phytase provides the utilization rate of phosphorus in feedstuff, eliminates the antinutritional factor in feedstuff, substitutes Phos, reduces dynamic
The content of phosphorus in thing feces, mitigates the pollution to environment；
4th, Digestive Enzyme can promote the absorption of fat and albumen, reduces the chance wasting and suffering from diarrhoea, and promotes fat-soluble nutrients unit
The absorption of element, reduces pigment and adds cost；
5th, the xylanolitic in feedstuff can be become less fragment by xylanase, decrease the bracing of mesh-shape hydrogel
And formation, it is that waterpower declines with the generation of this decomposition, significantly reduces intestinal chyme viscosity, eliminate the anti-of xylan
Nutrition；
6th, amylase and glucanase act synergistically on starch, promote the digestion of starchy material in feedstuff.
In sum, described compound enzymic preparation activates the secretion of endogenous enzymes, supplements the deficiency of endogenous enzymes, each enzyme specificity enzyme
In solution prawn feed, different macromole nutritional labelings, have effectively facilitated the digestive function of gut of shrimp, thus playing raising growth
Rate and digestibility, reduce the effect of feed coefficient.
Digestive tract due to fish and shrimp aquatic animal does not contain xylanase, phytase and cellulase, and amylase activity is low,
And described compound enzymic preparation by the bioactive substance that one or more can be decomposed feed nutrition strand form micro
Additive, adds exogenous digestive enzyme in feedstuff, the strand of each nutrition composition in degradable fish and shrimp feedstuff, or its digestion
The composition of enzyme system in road, promotes the digestion of protein, starch and fat, improves food utilization efficiency.
Further illustrate, described adjuvant is silicon dioxide, maltodextrin and starch, and it accounts for described hepatopathy feedstuff of preventing and treating and adds
Plus the mass percent of agent is respectively as follows: silicon dioxide 0.1-3%；Maltodextrin 20-37%；Starch 10-20%.
Described silicon dioxide is also called river sand, as the carrier of feed additive, mainly increases the gastric motility of aquatic animal,
Contribute to digesting, square is applied in poultry feed, had preferably by adding the feed additive of described silicon dioxide simultaneously
Mobility and anticaking capacity, be easy to the feeding of aquatic animal.
Described Fructus Hordei Germinatus lake essence, for having preferable emulsification and thickening effect, has promotion formed product and suppresses well
The effect of product organizational structure, moulding property can be good, can prevent deformation of products from can improve product appearance again, easily be absorbed, extensively
It is applied to the basic adjuvant of feed product.
Described alphalise starch is pre-gelatinized starch again, contributes to the shaping of granule and ensures certain pellet hardness and durable
Property, increase stability in water for the aquatic feeds, reduce the dust in the course of processing, increase caking property, it is to avoid feedstuff is in water
It is easy to loose, so that aquatic animal is ingested and prevented being scattered and running off of nutrient substance.These are all known in the art content, no
Additionally repeat again.
Preferably, described vitamin is made up of vitamin b1, vitamin b2, nicotiamide, vitamin b6 and calcium pantothenate
Compound vitamin.Vitamin b1 promotes the gastric digestion of aquatic animal；Vitamin b2 to the reduction of aquatic animal vivo oxidation and adjusts
Ganglion cell's breathing plays an important role, and can improve the utilization rate of feedstuff；Vitamin b2 is in b vitamin, aquatic animal relatively to be attached most importance to
Will, and it is difficult a kind of vitamin meeting, easily deficiency disease it should be noted that feeding in aquatic animal；Calcium pantothenate is coenzyme a
Ingredient, participates in carbohydrate, fat and protein metabolism, calcium pantothenate and vitamin b2 using there being substantial connection, one
Planting another kind of requirement when lacking increases；Additionally, calcium pantothenate is very unstable, easily it is damaged when mixing with feedstuff；Vitamin b6
It is the important vitamin of involved in sugar, fat and protein metabolism；Nicotiamide is the ingredient of coenzyme i and coenzyme ii, becomes perhaps
The coenzyme of many dehydrogenases.
Using above-mentioned five kinds of materials as described compound vitamin, significantly increase the nutritional statuses of aquatic animal, can add
The resistances against diseases of strong fish body, promote the reparation of hepar damnification and hepatocellular regeneration.
Preferably, described enzyme preparation is the compound enzymic preparation being made up of neutral protease, cellulase and amylase.Pass through
Greatly improve protein digestibility after adding neutral protease, after adding amylase, the digestibility of starch, cellulose can be improved
Enzyme can activate the secretion of endogenous enzymes, supplement the deficiency of endogenous enzymes, and endogenous enzymes are adjusted it is ensured that animal normally digests suction
Receive function, play diseases prevention and somatotrophic effect.
Using above-mentioned three kinds of materials as described compound enzymic preparation, it is obviously promoted the digestion to nutrient substance for the aquatic animal
And absorption, reduce the generation of intestinal endotoxin, effectively improve feed digestibility.
A kind of preparation method of above-mentioned anti-hepatic feed additive, comprises the steps:
(1) by mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, dimension life
Plain 0.5-5%, enzyme preparation 0.2-20%, silicon dioxide 0.1-3%, maltodextrin 20-37% and starch 10-20% carry out powder
Broken, sieve, be mixed, obtain mixture a；
(2) according to existing process technology of preparing, described mixture a is pressed into agent, obtains anti-hepatic feedstuff and add
Agent.
Further illustrate, the described mesh number sieved is 24-80 mesh.According to the demand of technique preparation, the present invention is to through powder
The particle diameter of the blending ingredients after broken does not have the requirement of clear and definite specification, as long as the general requirement that component fineness meets feed additive is
Can, the fineness that the mixture thus pulverized is in the range of 24-80 mesh reaches preparation and requires, and is not developed in details in explanation here.
Further illustrate, described vitamin is vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin b6, dimension
One or more combination of raw element e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12；Described enzyme preparation be neutral protease,
One or more combination of cellulase, phytase, Digestive Enzyme, amylase, xylanase and glucanase.
Further illustrate, above-mentioned anti-hepatic feed additive is used for aquatic biological and cultivates.By anti-treating the liver
The feed additive of disease is widely used in aquatic biological cultivation, improves anti-hepatopathy ability and the vitality of aquatic biological, and reduction is raised
The cost that material is fed, improves the output value of aquatic biological.
With reference to specific embodiment, the present invention is described in detail.
The Vitamin U that embodiment 1-5 adopts elects compound vitamin as, and component is specially vitamin b1, vitamin b2, cigarette
Amide, vitamin b6 and calcium pantothenate；Enzyme preparation is preferably compound enzymic preparation, component be specially neutral protease, cellulase and
Amylase.
Embodiment 1:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, cigarette
Amide 0.3kg, vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase
12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh),
It is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feedstuff
Additive.
Embodiment 2:
Weigh bile acid 1kg, curcumin 15kg, L-carnitine 15kg, vitamin b1 0.1kg, vitamin b20.1kg, cigarette
Amide 0.1kg, vitamin b6 0.1kg, calcium pantothenate 0.1kg, neutral protease 2kg, cellulase 1kg, amylase 6kg, dioxy
SiClx 2.5kg, maltodextrin 37kg and α starch 20kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain mixture
a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Embodiment 3:
Weigh bile acid 15kg, curcumin 15kg, L-carnitine 0.1kg, vitamin b1 1kg, vitamin b21kg, nicotinoyl
Amine 1kg, vitamin b6 1kg, calcium pantothenate 1kg, neutral protease 4kg, cellulase 3kg, amylase 13kg, silicon dioxide
3kg, maltodextrin 31.9kg and α starch 10kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain mixture a；Press
According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Embodiment 4:
Weigh bile acid 20kg, curcumin 0.1kg, L-carnitine 15kg, vitamin b1 0.3kg, vitamin b2
0.3kg, nicotiamide 0.4kg, vitamin b6 1kg, calcium pantothenate 0.4kg, neutral protease 4kg, cellulase 3kg, amylase
12.5kg, silicon dioxide 3kg, maltodextrin 20kg and α starch 20kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed,
Obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains anti-hepatic feedstuff and add
Agent.
Embodiment 5:
Weigh bile acid 20kg, curcumin 15kg, L-carnitine 15kg, vitamin b1 0.6kg, vitamin b2 1kg, cigarette
Amide 0.4kg, vitamin b6 0.6kg, calcium pantothenate 0.2kg, neutral protease 0.05kg, cellulase 0.05kg, amylase
0.1kg, silicon dioxide 3kg, maltodextrin 24kg and α starch 20kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain
To mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Embodiment 6-9 adopt described vitamin be vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin b6,
One or more combination of vitamin e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12；Using described enzyme preparation be neutrality
One or more combination of protease, cellulase, phytase, Digestive Enzyme, amylase, xylanase and glucanase.
Embodiment 6:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, neutral protease 4kg, fibre
The plain enzyme 2.5kg of dimension, amylase 12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, mistake
Sieve (mesh number is 24-80 mesh), is mixed, obtains mixture a；According to existing process technology of preparing, described mixture a is pressed into agent,
Obtain preventing hepatic feed additive.
Note: the vitamin in this product is single vitamin b1.
Embodiment 7:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, nicotiamide 0.3kg, neutrality
Protease 4kg, cellulase 2.5kg, amylase 12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg
Pulverized, sieve (mesh number is 24-80 mesh), be mixed, obtain mixture a；According to existing process technology of preparing described mixing
Thing a is pressed into agent, obtains preventing hepatic feed additive.
Note: the vitamin in this product is the compound vitamin of vitamin b1 and nicotiamide.
Embodiment 8:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, cigarette
Amide 0.3kg, vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase
12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh),
It is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feedstuff
Additive.
Note: the vitamin in this product is the compound vitamin of vitamin b1, vitamin b6 and nicotiamide.
Embodiment 9:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, cigarette
Amide 0.3kg, vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase
12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh),
It is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feedstuff
Additive.
Note: the enzyme preparation in this product is single neutral protease.
Embodiment 10:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, cigarette
Amide 0.3kg, vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase
12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh),
It is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feedstuff
Additive.
Note: the enzyme preparation in this product is the compound enzymic preparation of neutral protease and cellulase.
The Vitamin U that comparative example 1-5 adopts elects compound vitamin as, and component is specially vitamin b1, vitamin
B2, nicotiamide, vitamin b6 and calcium pantothenate；Enzyme preparation is preferably compound enzymic preparation, and component is specially neutral protease, cellulose
Enzyme and amylase.
Comparative example 1:
Weigh curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, nicotiamide 0.3kg,
Vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase 12.5kg, silicon dioxide
0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain mixture
a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Note: this product is not add bile acid component.
Comparative example 2:
Weigh bile acid 20kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, nicotiamide 0.3kg,
Vitamin b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase 12.5kg, silicon dioxide
0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain mixture
a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Note: this product is not add curcumin.
Comparative example 3:
Weigh bile acid 20kg, curcumin 5kg, vitamin b1 0.3kg, vitamin b2 0.1kg, nicotiamide 0.3kg, dimension
Raw element b6 0.1kg, calcium pantothenate 0.04kg, neutral protease 4kg, cellulase 2.5kg, amylase 12.5kg, silicon dioxide
0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieve (mesh number is 24-80 mesh), are mixed, obtain mixture
a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains preventing hepatic feed additive.
Note: this product is not add L-carnitine.
Comparative example 4:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, neutral protease 4kg, cellulase 2.5kg, starch
Enzyme 12.5kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg are pulverized, and sieving, (mesh number is 24-80
Mesh), it is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains anti-hepatic
Feed additive.
Note: this product is not add compound vitamin.
Comparative example 5:
Weigh bile acid 20kg, curcumin 5kg, L-carnitine 3kg, vitamin b1 0.3kg, vitamin b2 0.1kg, cigarette
Amide 0.3kg, vitamin b6 0.1kg, calcium pantothenate 0.04kg, silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch
16kg is pulverized, and sieves (mesh number is 24-80 mesh), is mixed, obtains mixture a；According to existing process technology of preparing described
Mixture a is pressed into agent, obtains preventing hepatic feed additive.
Note: this product is not add compound enzymic preparation.
Comparative example 6:
Weigh silicon dioxide 0.1kg, maltodextrin 36.06kg and α starch 16kg is pulverized, sieving, (mesh number is 24-80
Mesh), it is mixed, obtain mixture a；According to existing process technology of preparing, described mixture a is pressed into agent, obtains feedstuff and add
Agent.
Note: this product is not add bile acid, curcumin, L-carnitine, compound vitamin and compound enzymic preparation.
Feed additive for each embodiment and comparative example preparation carries out effect proof property test.
Choose Penaeus vannamei 600, be divided into two groups, every group 300, the feedstuff of each embodiment and comparative example preparation is added
Plus agent carries out, by the consumption of 5g/kg, the feeding that feeds intake.Carry out the 30th day in experiment, observation each group prawn sign, record growth conditions,
Liver color state simultaneously scores (the corresponding table of standards of grading see table 1), Penaeus vannamei is weighed simultaneously, records and calculate
The indexs such as survival rate, feed coefficient, obtained experimental result see table 2- table 4.
Table 1 standards of grading correspond to table
Table 2 embodiment 1-5 growth-promoting effect
As seen from the results in Table 2:
(1) pass through embodiment 1 to can be seen that the component of embodiment 1 and consumption respectively with the contrast of embodiment 2-5 is most preferably to join
Side, the survival rate of the Penaeus vannamei said components than embodiment 2-5 high, feed coefficient is little, growth conditions and liver
The scoring fraction of state is high, and the corresponding numerical value in value range of other components has corresponding change, is respectively provided with preferably anti-
Hepatic effect.
Table 3 embodiment 6-10 growth-promoting effect
As seen from the results in Table 3:
(1) pass through embodiment 1 and can be seen that when other components are necessarily constant with the contrast of embodiment 6-8 respectively, using list
The feed additive of the complex preparation of one vitamin or two kinds of vitamin, all than the compound dimension implementing 1 adopted component
The survival rate of the fed Penaeus vannamei of additive of raw element is low, and feed coefficient will greatly, the commenting of growth conditions regulating liver-QI dirty situation
Divide fraction low；
(2) pass through embodiment 1 to can be seen that when other components are necessarily constant with the contrast of embodiment 9-10 respectively, adopt
The feed additive of the complex preparation of single enzyme preparation or two kinds of enzyme preparations, all ratios implement the compound of 1 adopted component
The survival rate of the fed Penaeus vannamei of feed additive of enzyme preparation is low, and feed coefficient is big, growth conditions regulating liver-QI
The scoring fraction of dirty situation is low.
(3) pass through above-mentioned provable, Vitamin U elects the compound vitamin implementing 1 as, and enzyme preparation is preferably embodiment 1
Compound enzymic preparation, its prepared feed additive is all good than the feeding effect of single vitamin or enzyme preparation.
Table 4 comparative example 1-6 growth-promoting effect
Result from table 4 and table 2:
(1) pass through embodiment 1 and can be seen that when other components are necessarily constant with comparative example 1-5 contrast respectively, no
Add bile acid, curcumin, L-carnitine, compound vitamin and compound enzymic preparation a certain component therein, Penaeus vannamei
Survival rate all adds the low of said components than embodiment 1, and feed coefficient is big, and the scoring of growth conditions regulating liver-QI dirty situation divides
Number is low；
(2) embodiment 1 and comparative example 6 contrast are passed through as can be seen that adding bile acid, curcumin, L-carnitine, multiple
Close vitamin and the feedstuff prepared by compound enzymic preparation, the survival rate of the Penaeus vannamei fed with all without any one
Component will height, feed coefficient is low, represents that feed for nursing is fewer, and the scoring fraction of growth conditions regulating liver-QI dirty situation will height.
In sum, the present invention with bile acid, curcumin, L-carnitine, compound vitamin and compound enzymic preparation each become
Point carry out scientific compatibility, the effect that the curcumin of prepared component and other components are combined can effectively prevent and treat aquatic animal fat
The hepatic disease such as liver, liver and gallbladder syndrome, improve survival rate, reduce feed coefficient, promote the digestion of aquatic animal nutrient substance to inhale
Receive, lift animal growth rate, improve the economic benefit of cultivation.
The above-mentioned description to embodiment is to be understood that and use invention for ease of those skilled in the art.
Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general
Principle is applied in other embodiment without through performing creative labour.Therefore, the invention is not restricted to above-described embodiment, ability
, according to the announcement of the present invention, the improvement made without departing from scope and modification all should be the present invention's for field technique personnel
Within protection domain.
Claims (10)
1. a kind of anti-hepatic feed additive is it is characterised in that calculate by mass percentage, comprising: bile acid 1-20%,
Curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin 0.5-5%, enzyme preparation 0.2-20% and adjuvant 30.1-60%.
2. according to claim 1 prevent hepatic feed additive it is characterised in that described vitamin be vitamin a,
The one of vitamin b1, vitamin b2, nicotiamide, vitamin b6, vitamin e, vitamin c, calcium pantothenate, Folic Acid and vitamin b12
Plant or multiple combination.
3. anti-hepatic feed additive according to claim 1 is it is characterised in that described enzyme preparation is neutral protein
One or more combination of enzyme, cellulase, phytase, Digestive Enzyme, amylase, xylanase and glucanase.
4. according to claim 1 prevent hepatic feed additive it is characterised in that described adjuvant be silicon dioxide,
Maltodextrin and starch, it accounts for the described mass percent preventing and treating hepatopathy feed additive and is respectively as follows: silicon dioxide 0.1-3%；
Maltodextrin 20-37%；Starch 10-20%.
5. anti-hepatic feed additive according to claim 1 is it is characterised in that described vitamin is by vitamin
B1, vitamin b2, the compound vitamin of nicotiamide, vitamin b6 and calcium pantothenate composition.
6. anti-hepatic feed additive according to claim 1 is it is characterised in that described enzyme preparation is by neutral egg
The compound enzymic preparation of white enzyme, cellulase and amylase composition.
7. a kind of preparation method preventing hepatic feed additive is it is characterised in that comprise the steps:
(1) by mass percentage, by bile acid 1-20%, curcumin 0.1-15%, L-carnitine 0.1-15%, vitamin
0.5-5%, enzyme preparation 0.2-20%, silicon dioxide 0.1-3%, maltodextrin 20-37% and starch 10-20% are pulverized,
Sieve, be mixed, obtain mixture a；
(2) described mixture a is pressed into agent, obtains preventing hepatic feed additive.
8. the preparation method preventing hepatic feed additive according to claim 7 is it is characterised in that described sieve
Mesh number is 24-80 mesh.
9. the preparation method preventing hepatic feed additive according to claim 7 is it is characterised in that described vitamin
For vitamin a, vitamin b1, vitamin b2, nicotiamide, vitamin b6, vitamin e, vitamin c, calcium pantothenate, Folic Acid and Wei Sheng
One or more combination of plain b12；Described enzyme preparation is neutral protease, cellulase, phytase, Digestive Enzyme, amylase, wood
Dextranase and one or more combination of glucanase.
10. the anti-hepatic feed additive as described in any one in claim 1-6 is used for aquatic biological cultivation.
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| CN201610729670.6A CN106360115A (en) | 2016-08-26 | 2016-08-26 | Feed additive for preventing and treating liver diseases and preparation method of same |
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| CN201610729670.6A CN106360115A (en) | 2016-08-26 | 2016-08-26 | Feed additive for preventing and treating liver diseases and preparation method of same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993715A (en) * | 2017-03-15 | 2017-08-01 | 苏州大学 | Feed for preventing and treating white feces of prawns |
| CN108185218A (en) * | 2017-12-19 | 2018-06-22 | 天邦食品股份有限公司 | A kind of dedicated feed addictive of grass carp protect liver |
| CN108185121A (en) * | 2018-01-22 | 2018-06-22 | 通威股份有限公司 | A kind of middle Warsaw loach starter diet and preparation method thereof and application method |
| CN108606187A (en) * | 2018-04-19 | 2018-10-02 | 广东联鲲集团有限公司 | It is a kind of prevent golden pomfret hepatic disease additive and its application |
| CN109170365A (en) * | 2018-09-14 | 2019-01-11 | 广东渔夫宝水产科技有限公司 | A kind of functional feedstuff additive and its application method of cultured fishes liver protecting |
| CN112890048A (en) * | 2021-01-25 | 2021-06-04 | 重庆斯特佳生物科技有限公司 | Initial feed for improving survival rate of sturgeon fries |
| CN114886048A (en) * | 2022-04-06 | 2022-08-12 | 诺立(上海)生物工程有限公司 | Compound conditioner for repairing liver pathological changes of aquatic animals |
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| CN103392932A (en) * | 2013-07-26 | 2013-11-20 | 广东海大畜牧兽医研究院有限公司 | Compound feed for jade perch and spot fish cultivation and preparation method thereof |
| CN103719639A (en) * | 2014-01-24 | 2014-04-16 | 青岛根源生物技术集团有限公司 | Compound enzyme feed additive capable of improving growth rate and non-specific immunity of prawns and application thereof |
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| CN103392932A (en) * | 2013-07-26 | 2013-11-20 | 广东海大畜牧兽医研究院有限公司 | Compound feed for jade perch and spot fish cultivation and preparation method thereof |
| CN103719639A (en) * | 2014-01-24 | 2014-04-16 | 青岛根源生物技术集团有限公司 | Compound enzyme feed additive capable of improving growth rate and non-specific immunity of prawns and application thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993715A (en) * | 2017-03-15 | 2017-08-01 | 苏州大学 | Feed for preventing and treating white feces of prawns |
| CN106993715B (en) * | 2017-03-15 | 2019-09-03 | 苏州大学 | Feed for preventing and treating white feces of prawns |
| CN108185218A (en) * | 2017-12-19 | 2018-06-22 | 天邦食品股份有限公司 | A kind of dedicated feed addictive of grass carp protect liver |
| CN108185121A (en) * | 2018-01-22 | 2018-06-22 | 通威股份有限公司 | A kind of middle Warsaw loach starter diet and preparation method thereof and application method |
| CN108606187A (en) * | 2018-04-19 | 2018-10-02 | 广东联鲲集团有限公司 | It is a kind of prevent golden pomfret hepatic disease additive and its application |
| CN109170365A (en) * | 2018-09-14 | 2019-01-11 | 广东渔夫宝水产科技有限公司 | A kind of functional feedstuff additive and its application method of cultured fishes liver protecting |
| CN112890048A (en) * | 2021-01-25 | 2021-06-04 | 重庆斯特佳生物科技有限公司 | Initial feed for improving survival rate of sturgeon fries |
| CN114886048A (en) * | 2022-04-06 | 2022-08-12 | 诺立(上海)生物工程有限公司 | Compound conditioner for repairing liver pathological changes of aquatic animals |
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Application publication date: 20170201 |