CN109170365A - A kind of functional feedstuff additive and its application method of cultured fishes liver protecting - Google Patents

A kind of functional feedstuff additive and its application method of cultured fishes liver protecting Download PDF

Info

Publication number
CN109170365A
CN109170365A CN201811076392.4A CN201811076392A CN109170365A CN 109170365 A CN109170365 A CN 109170365A CN 201811076392 A CN201811076392 A CN 201811076392A CN 109170365 A CN109170365 A CN 109170365A
Authority
CN
China
Prior art keywords
liver
additive
cultured fishes
feed
liver protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811076392.4A
Other languages
Chinese (zh)
Inventor
雷静
周永奎
周永亮
许秋怡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Fisherman Bao Aquatic Products Technology Co Ltd
Original Assignee
Guangdong Fisherman Bao Aquatic Products Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Fisherman Bao Aquatic Products Technology Co Ltd filed Critical Guangdong Fisherman Bao Aquatic Products Technology Co Ltd
Priority to CN201811076392.4A priority Critical patent/CN109170365A/en
Publication of CN109170365A publication Critical patent/CN109170365A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)

Abstract

Include the component of following dosage the invention proposes the functional feedstuff additive and its application method of a kind of cultured fishes liver protecting, in every 1000g additive: curcumin 80-120g, 98% beet alkali hydrochlorate 120-180g, taurine 80-120g, 80% bile acid 160-240g, silymarin 30-80g, Radix Glycyrrhizae extract element 60-140g, saltcake 250-340g.The present invention can quickly repair liver cell, promote bile secretion, reduce liver fat accumulation, quickly activation immunity of organism, the fast quick-recovery of organism metabolism is set to run well, can effectively degrading, the various mycotoxins in feed and water body medicine are residual, metabolic problems caused by the infiltration body such as ammonia nitrogen, nitrous acid when deteriorating, free radical can efficiently be removed, reduce the destruction to liver and hepatopancrease, fry, shrimp, crab seedling percent are improved, the fruits such as the enlargement of prawn crab hepatopancrease, hepatatrophy, red liver, yellow liver, flower liver are significant.

Description

A kind of functional feedstuff additive and its application method of cultured fishes liver protecting
Technical field
The present invention relates to field of feed additive technology, particularly relate to a kind of functional feed of cultured fishes liver protecting Additive.
Background technique
Cultured fishes fatty liver is the wide hair venereal disease evil for perplexing culture fishery many years, though it is studied and is prevented and treated for many years Practice, cannot still be contained at all so far.More precisely fatty,fiss liver is a kind of describe to be more than fish normal hepatocytes The general designation of physiological phenomenon and relevant metabolic disease that the excessive liver rouge accumulation of rouge content is characterized.It endangers main packet It includes 4 aspects: 1. reducing growth performance and food utilization efficiency, increase aquaculture cost；2. immunity and stress tolerance are reduced, Increase the sensibility and the death rate to disease；3. reducing the organoleptic quality of product, product sale is influenced；4. leading to antibiotic indirectly The abuse of equal drugs, influences edible safety.
At present in the product scope of fish liver protection, has the patent of some liver-protecting products (such as: 201410359787.0 Hes 201110245640.5), the liver protection ingredient of this kind of patents, primarily directed to being absorbed and utilized for fat, however, liver is being metabolized When fatty, many oxygen radicals, the excessively high damage that will increase liver cell of oxygen radical can be generated, and then influences liver to rouge The metabolism of fat.In addition, there are also patent, (such as: 201610136687.0), consideration addition Chinese herbal medicine repairs hepatic injury, to prevent Fatty liver, but fish are very low to the absorption of the effective component in Chinese herbal medicine, moreover, simple Chinese herbal medicine is pulverized and mixed, In premix or feed making, mixed uniformity coefficient is relatively low.
Summary of the invention
In view of the above-mentioned problems existing in the prior art, this application provides a kind of functionality of cultured fishes liver protecting to raise Feed additives.
In order to solve the above technical problems, the present invention is achieved by the following scheme:
A kind of functional feedstuff additive of cultured fishes liver protecting includes following dosage in every 1000g additive Component:
Curcumin 80-120g, 98% beet alkali hydrochlorate 120-180g, taurine 80-120g, 80% bile acid 160- 240g, silymarin 30-80g, Radix Glycyrrhizae extract element 60-140g, saltcake 250-340g.
Preferably, the functional feedstuff additive of above-mentioned cultured fishes liver protecting wraps in every 1000g additive Include the component of following dosage:
Curcumin 100g, 98% beet alkali hydrochlorate 150g, taurine 100g, 80% bile acid 200g, silymarin 50g, Radix Glycyrrhizae extract element 100g, saltcake 300g.
The application method of the functional feedstuff additive of cultured fishes liver protecting of the invention presses 100g- with feed The amount of 200/40kg adds stirring, and specific dosage suitably increases according to coincident with severity degree of condition, and then plus water is stirred evenly with feed, The full pool is splashed, and feed is splashed dosage are as follows: outer pool 200-250g/ mus/ meter Shui Shen；Industrial aquaculture, every cube of water body 1-2g.
The present invention has the beneficial effect that compared with prior art
(1) strong liver cholagogic: for organism metabolism obstacle caused by aquatic livestock nutrient imbalance, show as white liver, flower liver, Gollbladder dilation, unsticking, which fall the symptoms such as squama, can quickly repair liver cell using this product, promote bile secretion, reduce liver fat product It is tired, immunity of organism is quickly activated, the fast quick-recovery of organism metabolism is made to run well.
(2) toxin is discharged: the various mycotoxins and water body medicine that this product can effectively degrade in feed are residual, ammonia nitrogen when deteriorating, Nitrous acid etc. permeate body caused by metabolic problems, mycotoxin and water body toxin to fish liver, shrimp, crab hepatopancrease and itself Immune system all has sizable destruction, and the endotoxin antagonism factor and Chinese herbal medicine extract of this product addition can effectively drop Toxolysin repairs immunity of organism.
(3) steatohepatitis, liver fiber anti-oxidation stress: are caused to liver destruction for the free radical that fat oxidation generates Change and the symptoms such as hepatonecrosis, this product can efficiently remove free radical, reduces the destruction to liver and hepatopancrease.
(4) survival rate for improving fry, to fish breaststroke, anorexia, nutritional fatty liver, flower liver, green liver, hepatonecrosis effect Significantly.
(5) turned for shrimp the liver phase, turn material phase, weather and water quality mutation, adhere to spice, improve shrimp, crab seedling percent, it is right The fruits such as the enlargement of shrimp crab hepatopancrease, hepatatrophy, red liver, yellow liver, flower liver are significant.
Specific embodiment
The present invention is got information about to allow those skilled in the art to be more clear, the present invention will be made below further Explanation.
Embodiment 1
The functional feedstuff additive of the cultured fishes liver protecting of the present embodiment includes as follows in every 1000g additive The component of dosage:
It is curcumin 80g, 98% beet alkali hydrochlorate 180g, taurine 80g, 80% bile acid 240g, silymarin 30, sweet Grass extracts element 140g, saltcake 250g.
Embodiment 2
The functional feedstuff additive of the cultured fishes liver protecting of the present embodiment includes as follows in every 1000g additive The component of dosage:
Curcumin 100g, 98% beet alkali hydrochlorate 150g, taurine 100g, 80% bile acid 200g, silymarin 50g, Radix Glycyrrhizae extract element 100g, saltcake 300g.
Embodiment 3
The functional feedstuff additive of the cultured fishes liver protecting of the present embodiment includes as follows in every 1000g additive The component of dosage:
Curcumin 120g, 98% beet alkali hydrochlorate 120g, taurine 120g, 80% bile acid 160g, silymarin 80g, Radix Glycyrrhizae extract element 60g, saltcake 340g.
The application method of the functional feedstuff additive of cultured fishes liver protecting described in embodiment 1-3, with feed Stirring is added by the amount of 100-200g/40kg, specific dosage suitably increases according to coincident with severity degree of condition, and then plus water is stirred with feed It mixes uniformly, the full pool is splashed, and feed is splashed dosage are as follows: outer pool 200-250g/ mus/ meter Shui Shen；Industrial aquaculture, every cube of water body 1- 2g。
Effect test 1:
The additive for selecting embodiment 2 adds soybean oil in crucian carp feed and this product, control group is crucian carp feed, The influence to crucian liver function and immunocompetence is verified, as a result see the table below 1.
Table 1 adds influence of this product to crucian liver function and immunocompetence
Effect test 2:
The additive of embodiment 2 is selected to verify whether this product can effectively improve in feed the utilization rate of vegetable seed grease and right The influence of crucian liver function and immune function.Control group is the feed containing 6% vegetable seed, and experimental group is the feeding containing 6% vegetable seed This product is added in material, as a result as follows:
Table 2 adds influence of this product to the feed containing vegetable seed to the liver function and immune function of cultivation crucian
Illustrating from table above, addition this product effectively improves the utilization rate of vegetable seed grease in feed, liver function protecting, Enhance fish immunity power, promotes fish growth.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (3)

  1. It include the group of following dosage 1. a kind of functional feedstuff additive of cultured fishes liver protecting, in every 1000g additive Point:
    Curcumin 80-120g, 98% beet alkali hydrochlorate 120-180g, taurine 80-120g, 80% bile acid 160-240g, Silymarin 30-80g, Radix Glycyrrhizae extract element 60-140g, saltcake 250-340g.
  2. 2. the functional feedstuff additive of cultured fishes liver protecting according to claim 1, which is characterized in that every Include the component of following dosage in 1000g additive:
    It is curcumin 100g, 98% beet alkali hydrochlorate 150g, taurine 100g, 80% bile acid 200g, silymarin 50g, sweet Grass extracts element 100g, saltcake 300g.
  3. 3. the application method of the functional feedstuff additive of cultured fishes liver protecting according to claim 1 or 2, special Sign is, adds and stirs by the amount of 100g-200/40kg with feed, and then plus water is stirred evenly with feed, and the full pool is splashed, and is raised Expect dosage of splashing are as follows: outer pool 200-250g/ mus/ meter Shui Shen；Industrial aquaculture, every cube of water body 1-2g.
CN201811076392.4A 2018-09-14 2018-09-14 A kind of functional feedstuff additive and its application method of cultured fishes liver protecting Pending CN109170365A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811076392.4A CN109170365A (en) 2018-09-14 2018-09-14 A kind of functional feedstuff additive and its application method of cultured fishes liver protecting

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811076392.4A CN109170365A (en) 2018-09-14 2018-09-14 A kind of functional feedstuff additive and its application method of cultured fishes liver protecting

Publications (1)

Publication Number Publication Date
CN109170365A true CN109170365A (en) 2019-01-11

Family

ID=64911498

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811076392.4A Pending CN109170365A (en) 2018-09-14 2018-09-14 A kind of functional feedstuff additive and its application method of cultured fishes liver protecting

Country Status (1)

Country Link
CN (1) CN109170365A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110710611A (en) * 2019-11-05 2020-01-21 淮安市澳华农牧有限公司 Application of bile acid in feed for promoting T-2 toxin metabolism in broiler chickens
CN113016963A (en) * 2021-04-27 2021-06-25 深圳市沙利文生物科技有限公司 Fish feed additive containing traditional Chinese medicine components

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101744122A (en) * 2009-12-28 2010-06-23 浙江科盛饲料股份有限公司 Feed additive, feed and preparation method thereof for preventing nutritional fatty liver of fish
CN102210411A (en) * 2011-06-08 2011-10-12 广东恒兴饲料实业股份有限公司 Compound feed capable of improving fatty liver and body colour of marine fish and preparation method thereof
CN105851521A (en) * 2016-05-23 2016-08-17 中国海洋大学 Composite additive for reducing liver fat deposition of turbots
CN106360115A (en) * 2016-08-26 2017-02-01 佛山市南海东方澳龙制药有限公司 Feed additive for preventing and treating liver diseases and preparation method of same
CN108185218A (en) * 2017-12-19 2018-06-22 天邦食品股份有限公司 A kind of dedicated feed addictive of grass carp protect liver

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101744122A (en) * 2009-12-28 2010-06-23 浙江科盛饲料股份有限公司 Feed additive, feed and preparation method thereof for preventing nutritional fatty liver of fish
CN102210411A (en) * 2011-06-08 2011-10-12 广东恒兴饲料实业股份有限公司 Compound feed capable of improving fatty liver and body colour of marine fish and preparation method thereof
CN105851521A (en) * 2016-05-23 2016-08-17 中国海洋大学 Composite additive for reducing liver fat deposition of turbots
CN106360115A (en) * 2016-08-26 2017-02-01 佛山市南海东方澳龙制药有限公司 Feed additive for preventing and treating liver diseases and preparation method of same
CN108185218A (en) * 2017-12-19 2018-06-22 天邦食品股份有限公司 A kind of dedicated feed addictive of grass carp protect liver

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110710611A (en) * 2019-11-05 2020-01-21 淮安市澳华农牧有限公司 Application of bile acid in feed for promoting T-2 toxin metabolism in broiler chickens
CN113016963A (en) * 2021-04-27 2021-06-25 深圳市沙利文生物科技有限公司 Fish feed additive containing traditional Chinese medicine components

Similar Documents

Publication Publication Date Title
CN101889664B (en) Chinese herb medicinal additive for preventing tilapia fatty liver disease
CN101548728B (en) Chinese herbal medicine additive for improving meat quality of java tilapia
CN101233903A (en) Fodder for cultivating southern American white prawn
CN103598441A (en) Black carp feed capable of reducing incidence of diseases
CN103583886B (en) A kind of chicken feed preventing global-worm illness
CN105394452A (en) Special feed for mandarin fish fries
CN104054959A (en) Laying hen feed
CN105558424A (en) Special feed formulation for giant salamanders
CN104957438A (en) Fish feed for preventing enteritis of Pseudobagrus fulvidraco and preparation method of fish feed
CN101773217B (en) Low-sugar, high-fat and slow-precipitation type micropterus salmoides expanded formulated pellet feed and preparation method thereof
CN109170365A (en) A kind of functional feedstuff additive and its application method of cultured fishes liver protecting
CN102450516A (en) Compound feed for carp
CN103734496A (en) Broiler green formula feed with effect of incidence rate reducing
CN103110032B (en) Pomfret compound feed with anti-stress and growth prompting function
CN104770616B (en) Pig feed for improving feed conversion rate
CN103766660A (en) Pig feed containing no antibiotics or other synthetic drugs and preparation method of pig feed
CN104757303A (en) Feed for preventing desquamation bleeding of megalobrama amblycephala in high-density breeding condition
CN104068245A (en) Cured bouquet fish feed and preparation method thereof
CN106578358A (en) Expanded feed for grass carp and tropical fish and preparation method of expanded feed
CN106360118A (en) Additive for crayfishes
CN103750043B (en) A kind of formula forage improving pork pig ketone body quality
CN108813127A (en) A kind of frog feed and preparation method thereof
CN108850546A (en) A kind of Cortex Eucommiae functional feed additive and preparation method thereof
CN104431613A (en) Feed for lowering grass carp morbidity and prepration method of feed
CN103110031B (en) Trachinotus ovatus compound feed with anti-stress function

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20190111