CN107996857A - A kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet and preparation method and application - Google Patents
A kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet and preparation method and application Download PDFInfo
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- CN107996857A CN107996857A CN201711343631.3A CN201711343631A CN107996857A CN 107996857 A CN107996857 A CN 107996857A CN 201711343631 A CN201711343631 A CN 201711343631A CN 107996857 A CN107996857 A CN 107996857A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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Abstract
The present invention relates to a kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet and preparation method and application, belong to field of fodder.Above-mentioned liquid amino acid vitamine supplement includes alanyl glutamine dipeptide, sodium butyrate, multi-vitamins, compound amino acid, xylo-oligosaccharide, emulsifying agent, antistaling agent.This liquid amino acid vitamine supplement can improve the nutritive digestibility of piglet, adjust intestinal microecology balance, improve body anabolism critical nutrients, strengthen protein synthesis, promote growth performance, improve child care survival rate.Its preparation method comprises the following steps：Aqueous phase solution and oil-phase solution are prepared respectively, are mixed aqueous phase solution and oil-phase solution, are obtained liquid amino acid vitamine supplement.This preparation method is simple, easy to operate.Above-mentioned beverage is used to prepare pig starter feed, the feed intake of weanling pig can be increased, improves daily gain, reduces Post Weaning Diarrhea rate, alleviates the weaning stress of weanling pig.
Description
Technical field
The present invention relates to field of fodder, and more particularly to a kind of liquid amino acid, vitamine for reducing weaning stress of piglet adds
Add agent and preparation method and application.
Background technology
Early weaning is that Pig Industry field improves sow utilization rate, increases the most basic mode of production of pig farm economic benefit,
So feeding management and the feed nutrition of transition stage are supplied just into the key link of this technology success or not after wean,
In this case, many pig farms cause son due to not more preferable transition stage feeding management and feed nutrition key technology
Pig feed intake reduces serious, or even hair is thick disorderly, lose flesh, severe diarrhea, survival rate are low etc. occurs, causes efficiency of feed utilization poor,
Slow-growing, growth and development stagnates and even forms cad pig, and immunity reduces, and the resistance of disease is weakened, easy scabies secondary infection
The phenomenon of other diseases, weaning stress of piglet syndrome serious threat have arrived the sound development of pig breeding industry.
Therefore, the product that can alleviate weaning stress of piglet syndrome is found into breeding enterprise, feed companies and is moved
The common objective of thing health products Co., Ltd.
The content of the invention
It is an object of the present invention to providing a kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet,
The liquid amino acid vitamine supplement first can repair piglet gastrointestinal tract mucosa epithelial cell, and energy is provided for enteron aisle fine hair
Material, promotes intestinal villus growth, improves nutritive digestibility；Second can adjust intestine of young pigs microecological balance, promote to have
Beneficial bacteria is grown, and produces short chain volatile aliphatic acid, strengthens intestines peristalsis, reduces gut pH, kills harmful bacteria；3rd can carry
High piglet body anabolism critical nutrients, strengthen protein synthesis, promote growth performance, improve feed intake, increase increases day by day
Weight, improves child care survival rate.
The second object of the present invention is to provide a kind of preparation method of above-mentioned liquid amino acid vitamine supplement, the system
Preparation Method is simple, easy to operate.
The third object of the present invention is to provide a kind of application of above-mentioned liquid amino acid vitamine supplement, is applied
In preparing pig starter feed, the feed intake of weanling pig can be effectively increased, improves daily gain, reduces Post Weaning Diarrhea rate, is alleviated disconnected
The weaning stress of milk piglet.
The present invention is solved its technical problem and is realized using following technical scheme：
The present invention proposes a kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet, its raw material includes 0.5-
The alanyl-glutamine dipeptides of 10 parts by weight, the sodium butyrate of 0.5-10 parts by weight, the compound dimension of 0.718-14.27 parts by weight
Raw element, the compound amino acid of 0.14-2.08 parts by weight, the xylo-oligosaccharide of 0.1-2 parts by weight, 1-20 parts by weight emulsifying agent and
The antistaling agent of 0.01-2 parts by weight.
Multi-vitamins include vitamin A, B family vitamin, vitamin D, vitamin E and biotin.
Compound amino acid includes lysine, methionine, tryptophan, threonine, phenylalanine, isoleucine, leucine, figured silk fabrics
Propylhomoserin, arginine and histidine.
The present invention also proposes a kind of preparation method of above-mentioned liquid amino acid vitamine supplement, comprises the following steps：Point
Aqueous phase solution and oil-phase solution are not prepared, are mixed aqueous phase solution and oil-phase solution, are obtained liquid amino acid vitamine supplement.
Aqueous phase solution is obtained through following steps：By B family vitamin, biotin, alanyl-glutamine dipeptides, sodium butyrate,
Compound amino acid, xylo-oligosaccharide and antistaling agent are dissolved in the water.
Preferably, the temperature of water is 75-85 DEG C.
Oil-phase solution is obtained through following steps：Blended emulsifier, vitamin A, vitamin D and vitamin E.
The present invention also proposes application of the above-mentioned liquid amino acid vitamine supplement in pig starter feed is prepared.
The liquid amino acid vitamine supplement and its system for the reduction weaning stress of piglet that present pre-ferred embodiments provide
Preparation Method and the beneficial effect of application are：
(1) product of the present invention is supplied with liquid concentrating function acidic amino acid vitamin form, reduces solid feed to disconnected
The feeding of milk piglet stress.
(2) product of the present invention can repair the intestinal epithelial cell of piglet damage, be provided for intestinal mucosa cells and intestinal villus
Energy, promotes intestinal villus growth, improves nutritive digestibility.
(3) product of the present invention can be combined with harmful bacteria surface external source coagulin, hinder harmful bacteria and enteric epithelium mucous membrane knot
Close, reduce the harm of harmful bacteria.
(4) product of the present invention can provide energy for intestinal beneficial bacterium such as Bacillus acidi lactici and Bifidobacterium, promote beneficial bacterium
Growth and breeding, adjusts intestinal flora balance, and activation beneficial bacterium produces metabolite short chain fatty acids, stimulates intestines peristalsis and reduction
Weanling pig gut pH.
(5) product of the present invention can be that piglet supplements enough vitamin, reduce the feed intake caused by weaning stress and reduce
And the influence of the vitamin insufficiency of intake occurred, for its body tissue grow and metabolic response provide necessary to coenzyme and prothetic group because
Son, catalysis carbohydrate, the eubolism of fat and protein, promote the perfect of tissue cell growth and immune function.
(6) product of the present invention can be that piglet supplements enough amino acid, reduce weanling pig because of solid protein of searching for food
The indigestion of appearance and cause trophism diarrhea problem, reduce because digestion decomposing protein into small peptide and amino acid needed for energy
Amount loss, quickly active factor is provided for body using Amino acid synthesis tissue protein.
(7) preparation method is simple, easy to operate.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
The liquid amino acid vitamine supplement of reduction weaning stress of piglet to the embodiment of the present invention and its preparation below
Method is specifically described with application.
Liquid amino acid vitamine supplement provided in an embodiment of the present invention, uses it for preparing pig starter feed, can increase
The feed intake of weanling pig, improves daily gain, reduces Post Weaning Diarrhea rate, strengthens fur glow, alleviates the wean of weanling pig
Stress, reduce the transitional period death rate.
Specifically, above-mentioned liquid amino acid vitamine supplement be after being mixed with piglet basal diet be used for for piglet into
Food.Optionally, the liquid amino acid vitamine supplement of 500-1500mL can be added in basal diet per ton, such as often
The liquid amino acid vitamine supplement of 500,1000mL and 1500mL can be added in ton basal diet, basic day preferably per ton
The liquid amino acid vitamine supplement of 1000mL is added in grain.It can make liquid amino acid contained in feed under the adding proportion
Vitamine supplement has excellent results, and cost performance is optimal.
The liquid amino acid vitamine supplement of the embodiment of the present invention contains the alanyl-glutamine of 0.5-10 parts by weight
Dipeptides, the sodium butyrate of 0.5-10 parts by weight, the multi-vitamins of 0.718-14.27 parts by weight, 0.14-2.08 parts by weight it is compound
Amino acid, the xylo-oligosaccharide of 0.1-2 parts by weight, the emulsifying agent of 1-20 parts by weight, the antistaling agent of 0.01-2 parts by weight.Specifically,
Per 100g liquid amino acid vitamine supplements contain the alanyl-glutamine dipeptides of 0.5-10g, 0.5-10g sodium butyrate,
The emulsification of the multi-vitamins of 0.718-14.27g, the compound amino acid of 0.14-2.08g, the xylo-oligosaccharide of 0.1-2g, 1-20g
Agent, the antistaling agent of 0.01-2g, surplus are pure water.
Wherein, multi-vitamins include vitamin A, B family vitamin, vitamin D, vitamin E and biotin.It is preferred that
Ground, above-mentioned multi-vitamins include the vitamin A of 0.1-2 parts by weight, the B family vitamin of 0.507-10.05 parts by weight, 0.01-
The biotin of the vitamin D of 0.2 parts by weight, the vitamin E of 0.1-2 parts by weight and 0.001-0.02 parts by weight.
Further, B family vitamin includes vitamin B1, vitamin B2, nicotinic acid, pantothenic acid, vitamin B6, folic acid and Wei Sheng
Plain B12.Preferably, the vitamin B1 of above-mentioned B family vitamin including 0.1-2 parts by weight, 0.1-2 parts by weight vitamin B2,
The nicotinic acid of 0.2-4 parts by weight, the pantothenic acid of 0.005-0.01 parts by weight, the vitamin B6 of 0.1-2 parts by weight, 0.001-0.02 weight
The folic acid of part and the vitamin B12 of 0.001-0.02 parts by weight.
Compound amino acid includes lysine, methionine, tryptophan, threonine, phenylalanine, isoleucine, leucine, figured silk fabrics
Propylhomoserin, arginine and histidine.Preferably, above-mentioned compound amino acid includes the lysine of 0.05-1 parts by weight, 0.05-1 weight
The methionine of part, the tryptophan of 0.005-0.01 parts by weight, the threonine of 0.005-0.01 parts by weight, 0.005-0.01 parts by weight
Phenylalanine, the isoleucine of 0.005-0.01 parts by weight, the leucine of 0.005-0.01 parts by weight, 0.005-0.01 weight
The valine, the arginine of 0.005-0.01 parts by weight and the histidine of 0.005-0.01 parts by weight of part.
Optionally, the emulsifying agent in the embodiment of the present invention can include alkylphenol polyoxyethylene ether, it is preferable that above-mentioned
Alkylphenol polyoxyethylene ether selects octyl phenol polyoxyethylene ether -10.Why the material is selected, its reason is this material
With after the liposoluble vitamin mixing in the embodiment of the present invention, it is not in turbid phenomenon that temperature, which reduces, final to ensure
Finished product viscosity is moderate and transparent.
Optionally, the antistaling agent in the embodiment of the present invention can include at least one in benzoic acid and sodium Diacetate
Kind, preferably include above two material at the same time.When including above two material at the same time, total dosage of benzoic acid and sodium Diacetate
Preferably 0.1 parts by weight.It is in view of the optimal pH of liquid amino acid vitamine supplement is 4.5- to select above two material
5.5, and the best use of pH value of above two material is just in the range of this.
On the one hand sodium butyrate in raw material can reduce the intracellular Ca of piglet2+Release, inhibition of histone deacetylase
(HDAC), it is horizontal to improve acetylation of histone, so as to suppress tumor cell proliferation, promote tumor cell senescence and apoptosis, raising
Intestinal villus growth, expand intestinal absorption area.On the other hand it can produce the butyric acid that can pass through cell membrane, to suppress harmful bacteria
Growth, promotes beneficial bacterium growth in intestines and stomach, micro ecology of gastrointestinal tract is in positive balance state.In addition, butyric acid absorbed through enteric cavity,
After oxidation quickly energy can be provided for intestinal epithelial cell.
What deserves to be explained is since sodium butyrate has very strong attractant smell, as liquid in the embodiment of the present invention
One of component of state amino acid, vitamine additive, can improve feed intake, the increase daily gain of weanling pig to a certain extent,
Improve food conversion ratio.
Alanyl-glutamine dipeptides is safe and stable, the efficient active carrier of glutamine, it can in enteron aisle
To discharge the precursor for purine biosynthesis ring, pyrimidine ring and amino sugar rapidly --- glutamine.In addition, alanyl-paddy
C, N donor that glutamine dipeptides is synthesized as the main energy sources and immunocyte nucleotide precursor of immune system, can maintain
The normal immune function of weanling pig.Also, alanyl-glutamine dipeptides can also adjust piglet body acid-base balance, promote
Intestinal mucosa cells division growth, suppresses enterocyte apoptosis, so as to maintain, repair enteron aisle structure to keep the complete of function of intestinal canal
Property.
Vitamin A is being protected the health of conjunctival epithelium tissue and nervous system, the normal breeding for maintaining body, growth and is being resisted
Sick power etc. plays an important roll, such as DNA can be promoted to transcribe, and adjusts metabolism and embryonic development, regulation and control secretion growth
The activity of hormone gene, promotes tissue differentiation and growth of animal.
Vitamin D is to maintaining calcium, phosphorus balance in animal body to play an important role.When calcium concentration reduces in blood, its
The calcium in bone tissue, phosphorus can be mobilized to enter blood, so as to maintain normal calcium level, and promote calcium to be deposited in bone.Together
When, vitamin D also by the mechanism of action similar to steroid hormone to many biological functions of animal (such as cell growth,
Differentiation and immune function, reproduction and the breeding of body, mineral metabolism etc.) it is adjusted.
Vitamin E is not only the most powerful natural of fat, also has many critical functions, such as increase nucleic acid generation
The synthesis of protein is thanked, promoted, the 26S Proteasome Structure and Function of biomembrane is protected, prevents necrosis of liver tissue and muscle damage, promotes to be immunized
The generation of globulin, improve animal body to the resistance of disease and enhancing anti-stress effect.
B family vitamin is each in catalysis carbohydrate, fat and protein metabolism mainly as coenzyme and prothetic group component
Kind reaction.Play in the B family vitamin of coenzyme existing interaction between various vitamins and show that these vitamins only have
Metabolism can be just sufficiently promoted in the case where playing a role jointly and animal is shown its expected generation performance, higher level
B family vitamin can improve Protein retention, improve growth rate, improve carcase quality.
Above-mentioned essential amino acid in raw material enter after alimentary canal need not move through that digestive ferment decomposes can be directly in small intestine quilt
Absorb and enter liver, a portion is decomposed in liver or synthetic protein, and another part continues to be distributed with blood
To each histoorgan to synthesize each species specific tissue protein.Amino acid can also pass through α -one caused by catabolism
Acid is metabolized through sugar or lipid metabolism approach, and 2-ketoacid can synthesize new amino acid again, or is changed into sugar or fat, or is entered
Tricarboxylic acid cycle oxygenolysis is into CO2And H2O, and release energy.What deserves to be explained is tryptophan and methionine etc. can also pass through
Catabolism generation methyl, methylene, methene, cresyl and formamino etc. are as purine biosynthesis and the primary raw material of pyrimidine
One carbon unit, become the tie contacted between amino acid and nucleotide.
Xylo-oligosaccharide enter alimentary canal after will not be digested enzyme degraded, and contestable and pathogen surface external source coagulate
Collection element combines, and hinders pathogen to stick in enteric epithelium, promotes it to be discharged with excrement, reduce the harm to animal.Also, pathogen
Cannot be by the use of xylo-oligosaccharide as the energy source of its growth, and beneficial bacterium such as Bacillus acidi lactici and Bifidobacterium etc. can be oligomeric
Xylose activates, and the metabolite short chain fatty acids that the beneficial bacterium after activation produces can stimulate intestines peristalsis, shortens chyme inside
Residence time, poisoned so as to reduce harmful substance caused by animal body.In addition, xylo-oligosaccharide is gone back as one of raw material
Adverse effect of the toxin to body can be eliminated by physical absorption or directly in conjunction with forms such as mycotoxins.Furthermore oligomeric wood
Sugar can also activate the effect of superoxide dismutase in body cell (SOD), catalase and glutathione peroxidase, promote
Oxide produces, and reduces the damage of free radical, improves antibody response ability.
Hold, intestinal mucosa recovery technique of the embodiment of the present invention based on weanling pig and enteron aisle small molecule nutriment
Direct absorption mode is combined and develops liquid amino acid vitamine supplement product, and on the one hand containing in the product to repair
Multiple intestine of young pigs damage Epithelial cell and for damaged epithelium provides energy nutrient and reparation sodium butyrate and alanyl-
Glutamine dipeptide, on the other hand contain provided for body tricarboxylic acid cycle and each tissue organ protein matter deposition it is comprehensive required
Amino acid and conditionally essential amino acid, key factor and profit are provided in addition, also containing for body eubolism and enzymatic reaction
Ten several vitamin substances of lubrication prescription, above reasonable composition add the liquid amino acid, vitamine in the embodiment of the present invention after coordinating
Add agent that there is reduction weanling pig, stress improve feed intake, increase daily gain, strengthen fur glow, reduce diarrhea, reduction transition
Phase death rate and other effects.
Since weanling pig is gradual from the behavior for sucking liquid breast milk to feeding solid religion groove child care material so that piglet disappears
Change road and physiological stress is caused to the burden of solid macromolecular nutrient digestion, in order to mitigate this transitional physiological stress,
The amino acid, vitamine functional product of the embodiment of the present invention uses liquid forms, on the one hand provides normal growth for piglet
Required micro critical nutrients and piglet is repaired due to gastrointestinal mucosal injury tissue caused by transitional period stress reaction, separately
On the one hand by using liquid preparation and liquid feed mode, the nutrition form searched for food before weaned piglet has been continued to use, had been reduced
Cross phase alimentary canal stress reaction.
Specifically, its preparation method may comprise steps of：Aqueous phase solution and oil-phase solution, mixing water phase are prepared respectively
Solution and oil-phase solution, obtain liquid amino acid vitamine supplement.
Wherein, aqueous phase solution can be obtained through following steps：By B family vitamin, biotin, alanyl-glutamine two
Peptide, sodium butyrate, compound amino acid, xylo-oligosaccharide and antistaling agent are dissolved in the water.
Specifically, pure water making system is opened, prepares the pure water needed for production, measures and produces the desired amount of water, is opened
Heating system, 75-85 DEG C is increased to by water temperature, is preferably 80 DEG C.By load weighted vitamin B1, vitamin B2, vitamin B6,
Vitamin B12, folic acid, nicotinic acid, pantothenic acid, biotin, alanyl-glutamine dipeptide, sodium butyrate, compound amino acid, oligomeric wood
Sugar, sodium Diacetate and benzoic acid input water phase pot, and are stirred continuously, until completely dissolved, reduce rapidly temperature to 50 DEG C it is spare.
Oil-phase solution is obtained through following steps：Blended emulsifier, vitamin A, vitamin D and vitamin E.
Specifically, octyl phenol polyoxyethylene ether -10, vitamin A, vitamin D and the vitamin E of formula ratio are weighed,
It is spare to be sufficiently stirred mixing.
The mixing of aqueous phase solution and oil-phase solution is that oil-phase solution is added in aqueous phase solution, is then sheared, homogeneous.Specifically
Ground, opens emulsification main cooker, vacuumizes, and aqueous phase solution is evacuated to emulsification main cooker, closes vacuum, opens cooling system, opens stirring
Machine (55-65 revs/min), oil-phase solution is slowly put into from material mouth to abundant dissolving.Vacuum is opened, stirring after ten minutes, is opened
Upper shearing (2800-3000 revs/min) while open after cooling system is sheared 6 minutes and continue stirring and treat that temperature is down to 35 degrees Celsius
Lower homogeneous (700-1000 revs/min) is opened below, is evacuated to storage tank, is prepared packaging.
Hold, the embodiment of the present invention adjusts fat-soluble and water-soluble substances parent by the surface active function of emulsifying agent
Hydrophile-lipophile balance value, makes up to certain stability range, and water oil dissolves each other to form the liquid of thin transparent equalization stable state.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
By the vitamin B1 of 0.1 parts by weight, the vitamin B2 of 0.1 parts by weight, the nicotinic acid of 0.2 parts by weight, 0.005 parts by weight
Pantothenic acid, the vitamin B6 of 0.1 parts by weight, the folic acid of 0.001 parts by weight, the vitamin B12 of 0.001 parts by weight, 0.001 weight
Part biotin, the alanyl-glutamine dipeptides of 0.5 parts by weight, the sodium butyrate of 0.5 parts by weight, 0.14 parts by weight it is compound
The antistaling agent of amino acid, the xylo-oligosaccharide of 0.1 parts by weight and 0.01 parts by weight is dissolved in 75 DEG C of water, obtains aqueous phase solution.
Wherein, compound amino acid contains the lysine of 0.05 parts by weight, the methionine of 0.05 parts by weight, 0.005 parts by weight
Tryptophan, the threonine of 0.005 parts by weight, the phenylalanine of 0.005 parts by weight, 0.005 parts by weight isoleucine,
The leucine of 0.005 parts by weight, the valine of 0.005 parts by weight, the group of the arginine of 0.005 parts by weight and 0.005 parts by weight
Propylhomoserin.Antistaling agent contains benzoic acid.
Mix the octyl phenol polyoxyethylene ether -10 of 1 parts by weight, the vitamin A of 0.1 parts by weight, 0.01 parts by weight
The vitamin E of vitamin D and 0.1 parts by weight, stirs and evenly mixs, and obtains oil-phase solution.
Aqueous phase solution is evacuated to emulsification main cooker, closes vacuum, opens cooling system, opens mixer (55 revs/min), from
Material mouth slowly puts into oil-phase solution to abundant dissolving.Vacuum is opened, stirring after ten minutes, (2800 revs/min) is sheared in unlatching,
Continue stirring after opening cooling system shearing at the same time 6 minutes and treat that temperature is down to less than 35 degrees Celsius and opens lower (700 revs/min of homogeneous
Clock), storage tank is evacuated to, prepares packaging, obtains liquid amino acid vitamine supplement.
Embodiment 2
By the vitamin B1 of 2 parts by weight, the vitamin B2 of 2 parts by weight, the nicotinic acid of 4 parts by weight, 0.01 parts by weight pantothenic acid,
The vitamin B6 of 2 parts by weight, the folic acid of 0.02 parts by weight, the vitamin B12 of 0.02 parts by weight, 0.02 parts by weight biotin,
The alanyl-glutamine dipeptides of 10 parts by weight, the sodium butyrate of 10 parts by weight, the compound amino acid of 2.08 parts by weight, 2 parts by weight
Xylo-oligosaccharide and the antistaling agents of 2 parts by weight be dissolved in 85 DEG C of water, obtain aqueous phase solution.
Wherein, compound amino acid contains the lysine of 1 parts by weight, the methionine of 1 parts by weight, the color ammonia of 0.01 parts by weight
Acid, the threonine of 0.01 parts by weight, the phenylalanine of 0.01 parts by weight, the isoleucine of 0.01 parts by weight, 0.01 parts by weight
Leucine, the valine of 0.01 parts by weight, the histidine of the arginine of 0.01 parts by weight and 0.01 parts by weight.Antistaling agent contains double
Sodium acetate.
Mix the octyl phenol polyoxyethylene ether -10 of 20 parts by weight, the vitamin A of 2 parts by weight, the dimension of 0.2 parts by weight
The vitamin E of raw element D and 2 parts by weight, stir and evenly mix, obtain oil-phase solution.
Aqueous phase solution is evacuated to emulsification main cooker, closes vacuum, opens cooling system, opens mixer (65 revs/min), from
Material mouth slowly puts into oil-phase solution to abundant dissolving.Vacuum is opened, stirring after ten minutes, (3000 revs/min) is sheared in unlatching,
Continue stirring after opening cooling system shearing at the same time 6 minutes and treat that temperature is down to less than 35 degrees Celsius and opens lower (1000 revs/min of homogeneous
Clock), storage tank is evacuated to, prepares packaging, obtains liquid amino acid vitamine supplement.
Embodiment 3
By the vitamin B1 of 1 parts by weight, the vitamin B2 of 1 parts by weight, the nicotinic acid of 2 parts by weight, 0.0075 parts by weight it is general
Acid, the vitamin B6 of 1 parts by weight, the folic acid of 0.01 parts by weight, the vitamin B12 of 0.01 parts by weight, the biology of 0.01 parts by weight
Element, the alanyl-glutamine dipeptides of 5.25 parts by weight, the sodium butyrate of 5.25 parts by weight, 1.11 parts by weight compound amino acid,
The xylo-oligosaccharide of 1 parts by weight and the antistaling agent of 0.1 parts by weight are dissolved in 80 DEG C of water, obtain aqueous phase solution.
Wherein, compound amino acid contains the lysine of 0.5 parts by weight, the methionine of 0.5 parts by weight, 0.0075 parts by weight
Tryptophan, the threonine of 0.0075 parts by weight, the phenylalanine of 0.0075 parts by weight, 0.0075 parts by weight isoleucine,
The leucine of 0.0075 parts by weight, the valine of 0.0075 parts by weight, the arginine of 0.0075 parts by weight and 0.0075 parts by weight
Histidine.Antistaling agent contains benzoic acid and sodium Diacetate.
Mix the octyl phenol polyoxyethylene ether -10 of 10.5 parts by weight, the vitamin A of 1 parts by weight, 0.1 parts by weight
The vitamin E of vitamin D and 1 parts by weight, stirs and evenly mixs, and obtains oil-phase solution.
Aqueous phase solution is evacuated to emulsification main cooker, closes vacuum, opens cooling system, opens mixer (60 revs/min), from
Material mouth slowly puts into oil-phase solution to abundant dissolving.Vacuum is opened, stirring after ten minutes, (2900 revs/min) is sheared in unlatching,
Continue stirring after opening cooling system shearing at the same time 6 minutes and treat that temperature is down to less than 35 degrees Celsius and opens lower (850 revs/min of homogeneous
Clock), storage tank is evacuated to, prepares packaging, obtains liquid amino acid vitamine supplement.
Test example 1
Repeat to implement above-described embodiment 1-3, obtain enough liquid amino acid vitamine supplement (hereinafter referred to as liquid
Dimension), by taking the liquid dimension of the gained of embodiment 3 as an example tests below is carried out as treatment group.Culture experiment is in the proud agriculture biotechnology in Fujian
Group Plc subordinate cultivation base carries out, and experiment uses single factor test completely randomized design, and selection health, weight are suitable
30 age in days Ternary Pig three way cross weanling pigs 120 (male and female is fifty-fifty), be randomly divided into 4 groups, each handle 2 repetitions, often
A 15 piglets of repetition, pre-feeding period 7 days, experimental period 15d.Each group is weighed when on-test and off-test, calculates each group
Piglet average daily gain (ADG)；Each group piglet feed consumption rate is counted during off-test, calculates average daily gain (ADFI), and count
Calculate feedstuff-meat ratio；Each group grice diarrhoea head number is counted daily and calculates diarrhea rate.Wherein, diarrhea rate=experimental period, respectively repeats accumulative son
The total head number of diarrhea of pigs/(experimental period respectively repeats total head number × experiment number of days) × l00%.Each group trophic level and addition scheme such as table
Shown in 1, result of the test is as shown in table 2.
1 each group trophic level of table and addition scheme
2 result of the test of table
As can be seen from Table 2, in terms of daily ingestion amount, treatment group 1, treatment group 2 and treatment group 3 are improved than control group respectively
3.72%, 14.88% and 6.81%；In terms of daily gain, treatment group 1, treatment group 2 and treatment group 3 are improved than control group respectively
3.69%, 9.98% and 6.57%；In terms of diarrhea rate, treatment group 1, treatment group 2 and treatment group 3 are reduced than control group respectively
24.20%th, 41.64% and 51.60%.Summary result is understood, liquid amino acid, vitamine is added in piglet diet and is added
Add agent to increase the feed intake of piglet, improve daily gain, reduce Post Weaning Diarrhea rate, alleviate the work(of weanling pig weaning stress
Energy.And contrast treatment group 1-3 is understood, the liquid amino acid, vitamine of 1000mL is added in control group 2 namely basal diet per ton
The best results that additive rises.
Test example 2
Using the liquid amino acid vitamine supplement of the gained of embodiment 3 as test group, control group 1- control groups 3 are set, it is right
According to group 1, difference lies in liquid amino acid vitamine supplement in control group 1 to be free of alanyl-glutamine two with test group
Peptide, difference lies in liquid amino acid vitamine supplement in control group 2 to be free of sodium butyrate, control group 3 for control group 2 and test group
Difference lies in liquid amino acid vitamine supplement in control group 3 to be free of xylo-oligosaccharide with test group.Contrast identical test bar
(the liquid amino acid vitamine supplement that 1000mL is added in basal diet per ton), the liquid ammonia of test group and control group under part
Base acid vitamine supplement is to the influence in terms of weanling pig daily ingestion amount, daily gain and diarrhea rate.
It is the results show that control group 1-3 is worse to weanling pig role compared with embodiment 3, specifically, control group
1-3 reduces 8.91%, 5.44% and 4.89 respectively compared with embodiment 3 in daily ingestion amount；Control group 1-3 is increasing day by day compared with embodiment 3
Reduce 12.33%, 10.74% and 7.25 respectively again；Control group 1-3 has been respectively increased 4.41% in diarrhea rate compared with embodiment 3,
4.63% and 6.68%.It follows that in liquid amino acid vitamine supplement whether containing alanyl-glutamine dipeptides,
Sodium butyrate and xylo-oligosaccharide have considerable influence to weanling pig daily ingestion amount, daily gain and diarrhea rate.
In addition, setting control group 4-6, control group 4 is free of alanyl-glutamine dipeptides and sodium butyrate, and control group 5 is free of
Alanyl-glutamine dipeptides and xylo-oligosaccharide, control group 6 are free of sodium butyrate and xylo-oligosaccharide, control group 7 without alanyl-
Glutamine dipeptide, sodium butyrate and xylo-oligosaccharide, using the experimental condition contrast control group 4-6 identical with above-mentioned experiment with implementing
The liquid amino acid vitamine supplement of example 3 is to the influence in terms of weanling pig daily ingestion amount, daily gain and diarrhea rate.
Itself the results show that control group 4-7 is worse compared with the effect that embodiment 3 and control group 1-3 play weanling pig,
Wherein, the effect of control group 7 is worst, and its effect well below any one group in control group 4-6 with it is right therewith in control group 1-3
The sum of one group effect answered (namely control group 4-6 combined with control group 1-3 after gained formula just contain the third ammonia at the same time
Acyl-glutamine dipeptide, sodium butyrate and xylo-oligosaccharide), illustrate alanyl-glutamine dipeptides, sodium butyrate and xylo-oligosaccharide it
Between exist synergistic effect.
Identical test is carried out to the liquid dimension of embodiment 1 and the gained of embodiment 2 according to the method for test example 1 and test example 2, its
As a result it is consistent with the result of the test effect of 3 liquid of embodiment dimension.
In conclusion liquid amino acid vitamine supplement provided by the invention can improve the nutrient digestion of piglet
Rate, adjust intestinal microecology balance, improve body anabolism critical nutrients, strengthen protein synthesis, promote growth performance,
Improve child care survival rate.Its preparation method is simple, easy to operate.Above-mentioned beverage is used to prepare pig starter feed, it is young that wean can be increased
The feed intake of pig, improves daily gain, reduces Post Weaning Diarrhea rate, alleviates the weaning stress of weanling pig.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of liquid amino acid vitamine supplement for reducing weaning stress of piglet, it is characterised in that its raw material includes 0.5-
The alanyl-glutamine dipeptides of 10 parts by weight, the sodium butyrate of 0.5-10 parts by weight, the compound dimension of 0.718-14.27 parts by weight
Raw element, the compound amino acid of 0.14-2.08 parts by weight, the xylo-oligosaccharide of 0.1-2 parts by weight, 1-20 parts by weight emulsifying agent and
The antistaling agent of 0.01-2 parts by weight；
The multi-vitamins include vitamin A, B family vitamin, vitamin D, vitamin E and biotin；
The compound amino acid includes lysine, methionine, tryptophan, threonine, phenylalanine, isoleucine, leucine, figured silk fabrics
Propylhomoserin, arginine and histidine.
2. the liquid amino acid vitamine supplement according to claim 1 for reducing weaning stress of piglet, it is characterised in that
The vitamin A of multi-vitamins including 0.1-2 parts by weight, the B family vitamin of 0.507-10.05 parts by weight,
The institute of the vitamin D of 0.01-0.2 parts by weight, vitamin E and the 0.001-0.02 parts by weight of 0.1-2 parts by weight
State biotin.
3. the liquid amino acid vitamine supplement according to claim 2 for reducing weaning stress of piglet, it is characterised in that
The B family vitamin includes vitamin B1, vitamin B2, nicotinic acid, pantothenic acid, vitamin B6, folic acid and vitamin B12；
Preferably, the B family vitamin includes the vitamin B1, the vitamin of 0.1-2 parts by weight of 0.1-2 parts by weight
The nicotinic acid of B2,0.2-4 parts by weight, the pantothenic acid of 0.005-0.01 parts by weight, the vitamin of 0.1-2 parts by weight
The vitamin B12 of folic acid and the 0.001-0.02 parts by weight of B6,0.001-0.02 parts by weight.
4. the liquid amino acid vitamine supplement according to claim 1 for reducing weaning stress of piglet, it is characterised in that
The compound amino acid includes the lysine, the methionine, the 0.005- of 0.05-1 parts by weight of 0.05-1 parts by weight
The tryptophan of 0.01 parts by weight, the threonine of 0.005-0.01 parts by weight, the benzene of 0.005-0.01 parts by weight
Alanine, the isoleucine of 0.005-0.01 parts by weight, the leucine, the 0.005-0.01 of 0.005-0.01 parts by weight
Described group of ammonia of the valine of parts by weight, arginine and the 0.005-0.01 parts by weight of 0.005-0.01 parts by weight
Acid.
5. the liquid amino acid vitamine supplement according to claim 1 for reducing weaning stress of piglet, it is characterised in that
The emulsifying agent is alkylphenol polyoxyethylene ether；
Preferably, the alkylphenol polyoxyethylene ether is octyl phenol polyoxyethylene ether -10.
6. the liquid amino acid vitamine supplement according to claim 1 for reducing weaning stress of piglet, it is characterised in that
The antistaling agent includes at least one of benzoic acid and sodium Diacetate.
7. as claim 1-6 any one of them reduces the preparation of the liquid amino acid vitamine supplement of weaning stress of piglet
Method, it is characterised in that comprise the following steps：Aqueous phase solution and oil-phase solution are prepared respectively, mix the aqueous phase solution and institute
Oil-phase solution is stated, obtains liquid amino acid vitamine supplement；
The aqueous phase solution is obtained through following steps：By the B family vitamin, the biotin, the alanyl-glutamine
Dipeptides, the sodium butyrate, the compound amino acid, the xylo-oligosaccharide and the antistaling agent are dissolved in the water；
Preferably, the temperature of water is 75-85 DEG C；
The oil-phase solution is obtained through following steps：Mix the emulsifying agent, the vitamin A, the vitamin D and the dimension
Raw element E.
8. preparation method according to claim 7, it is characterised in that the mixing of the aqueous phase solution and the oil-phase solution
It is that the oil-phase solution is added in the aqueous phase solution, then shears, homogeneous.
9. prepared by the liquid amino acid vitamine supplement that weaning stress of piglet is reduced such as claim 1-6 any one of them
Application in pig starter feed.
10. the liquid amino acid vitamine supplement according to claim 9 for reducing weaning stress of piglet is preparing piglet
Application in feed, it is characterised in that the liquid amino acid, vitamine that 500-1500mL is added in basal diet per ton adds
Add agent；
Preferably, the liquid amino acid vitamine supplement of 1000mL is added in basal diet per ton.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111642642A (en) * | 2020-06-30 | 2020-09-11 | 山东康裕生物科技有限公司 | Liquid multivitamin with high stability for weaned piglets |
| CN111713610A (en) * | 2020-07-17 | 2020-09-29 | 广东恒兴饲料实业股份有限公司 | Feed additive for promoting intestinal tract repair of weaned pigs and application thereof |
| CN114304409A (en) * | 2020-09-28 | 2022-04-12 | 河北科星药业有限公司 | Weaned piglet health feed additive and preparation method thereof |
| CN114601846A (en) * | 2020-12-03 | 2022-06-10 | 河北科星药业有限公司 | Complex vitamin amino acid injection for livestock and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461675A (en) * | 2013-09-23 | 2013-12-25 | 河南牧翔动物药业有限公司 | Livestock and poultry intestinal tract regulator and preparation method thereof |
| CN104522323A (en) * | 2014-12-19 | 2015-04-22 | 杨凌益佳泰生物科技有限公司 | Bicontinuous nanoemulsion with multiple victamins and preparation method thereof |
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105076862A (en) * | 2015-09-11 | 2015-11-25 | 安徽科技学院 | Anti-stress premix capable of promoting growth of piglets and preparation method of anti-stress premix |
| CN106509432A (en) * | 2016-11-03 | 2017-03-22 | 新希望六和股份有限公司 | Piglet intestinal health improving and weaning stress reducing creep feed and preparation method thereof |
| CN106974077A (en) * | 2017-03-23 | 2017-07-25 | 陕西金冠牧业有限公司 | A kind of nano nutrient liquid cultivated for weanling pig and preparation method thereof |
| CN107281304A (en) * | 2016-04-01 | 2017-10-24 | 瑞普（天津）生物药业有限公司 | A kind of Chinese veterinary medicinal composition and its preparation technology for treating grice diarrhoea |
-
2017
- 2017-12-14 CN CN201711343631.3A patent/CN107996857A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461675A (en) * | 2013-09-23 | 2013-12-25 | 河南牧翔动物药业有限公司 | Livestock and poultry intestinal tract regulator and preparation method thereof |
| CN104522323A (en) * | 2014-12-19 | 2015-04-22 | 杨凌益佳泰生物科技有限公司 | Bicontinuous nanoemulsion with multiple victamins and preparation method thereof |
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105076862A (en) * | 2015-09-11 | 2015-11-25 | 安徽科技学院 | Anti-stress premix capable of promoting growth of piglets and preparation method of anti-stress premix |
| CN107281304A (en) * | 2016-04-01 | 2017-10-24 | 瑞普（天津）生物药业有限公司 | A kind of Chinese veterinary medicinal composition and its preparation technology for treating grice diarrhoea |
| CN106509432A (en) * | 2016-11-03 | 2017-03-22 | 新希望六和股份有限公司 | Piglet intestinal health improving and weaning stress reducing creep feed and preparation method thereof |
| CN106974077A (en) * | 2017-03-23 | 2017-07-25 | 陕西金冠牧业有限公司 | A kind of nano nutrient liquid cultivated for weanling pig and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴家鑫等: "丙氨酰谷氨酰胺二肽在动物生产中的应用", 《饲料广角》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111642642A (en) * | 2020-06-30 | 2020-09-11 | 山东康裕生物科技有限公司 | Liquid multivitamin with high stability for weaned piglets |
| CN111713610A (en) * | 2020-07-17 | 2020-09-29 | 广东恒兴饲料实业股份有限公司 | Feed additive for promoting intestinal tract repair of weaned pigs and application thereof |
| CN114304409A (en) * | 2020-09-28 | 2022-04-12 | 河北科星药业有限公司 | Weaned piglet health feed additive and preparation method thereof |
| CN114601846A (en) * | 2020-12-03 | 2022-06-10 | 河北科星药业有限公司 | Complex vitamin amino acid injection for livestock and preparation method and application thereof |
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