CN109394675B - Skin care matrix for rapidly repairing skin and preparation method and application thereof - Google Patents
Skin care matrix for rapidly repairing skin and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a skin-care matrix for rapidly repairing skin, a preparation method and an application thereof, wherein the skin-care matrix comprises the following components: tremella polysaccharide, melissa officinalis extract, taxus chinensis stem cell extract and aloe extract. According to the invention, the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are compounded and used in the skin care matrix, and the combination of the four components can generate a synergistic interaction effect, so that the tremella polysaccharide can be efficiently applied to the field of skin repair. The skin care matrix disclosed by the invention has the effect of quickly repairing damaged skin, also has excellent antibacterial, bactericidal and anti-inflammatory effects and moisturizing effects, can effectively prevent wound surface bacterial infection and skin allergy, keep the wound surface moist, prevent the wound surface from being dry, lack of water and accumulated pus and flowing, can reduce the formation of scar tissue, and has a good application prospect in the aspect of healing of skin wounds.
Description
Technical Field
The invention relates to a composition for repairing skin, in particular to a skin-care matrix for quickly repairing skin, a preparation method and application thereof.
Background
The skin covers the whole body, being the largest organ of the human body, and protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microbial attacks. The wound surface is the damage of normal skin (tissue) caused by external injury factors such as surgery, external force, heat, current, chemical substances, low temperature and internal factors of the body such as local blood supply disorder, and is often accompanied by the damage of the integrity of the skin and the loss of a certain amount of normal tissue, and at the same time, the normal function of the skin is damaged. The ultimate goal of skin damage is to promote wound healing and reestablish or restore skin barrier function. The basic processes of wound healing include hemostasis, inflammatory response, cell proliferation, wound contraction, and tissue remodeling, which all require a microenvironment consistent with cell growth, and any factors affecting these processes and the environment affect the healing of the wound.
Traditional skin repair typically employs: transplanting autologous tissues; transplantation of variant tissues; and applying artificial substitute. Although good repairing effect is achieved in autologous tissue or organ transplantation, the autologous tissue or organ transplantation is limited by conditions such as lack of donor sources and need of secondary operations. Allogenic and xenogenic transplantation not only faces the limitation of few donor sources, but also has the risks of causing immune rejection, spreading pathogen and the like. Artificial substitutes can only serve to repair or fill limited tissues or organs. According to the research results of follow-up survey, the cure rate of all ulcers in half a year reaches 85%, but the recurrence rate reaches 1.7%, and the recurrence rate reaches 4.6% in 5 years. This suggests that the long-term prognosis of conventional therapies is not ideal and does not accelerate the healing process by these mechanisms.
The biological dressing with excellent performance can temporarily play a part of the role of skin barrier function, protect wounds, prevent moisture and body fluid from evaporating and losing from the wound surface, prevent pollution, accelerate the regeneration epithelization process formed by skin accessories, effectively relieve the pain of patients and provide an environment which is favorable for wound healing for the growth of new skin. Therefore, finding and manufacturing an ideal biological dressing is one of the important tasks for wound repair research. The polysaccharide is a long-chain saccharide, and various mushrooms and hypha thereof are rich in the polysaccharide, are important components of cells, have good affinity, can repair damaged cells, activate cells and vegetative cells, have good effects of eliminating inflammation and stopping bleeding, and are extremely beneficial to the immune system of a human body. Therefore, if the polysaccharide can be effectively applied to the field of skin wound repair, the polysaccharide has a very good market prospect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a skin-care matrix for quickly repairing skin and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: a skin care base comprising the following components: tremella polysaccharide, melissa officinalis extract, taxus chinensis stem cell extract and aloe extract.
Tremella (Tremella) is rich in Tremella polysaccharide, and belongs to acidic heterogeneous polysaccharide. Animal experiment research shows that the polysaccharide in tremella can lower blood sugar and low density cholesterol content, resist inflammation, promote lymphocyte proliferation, promote platelet cell activity, etc. and raise the immunity of body. The tremella polysaccharide has the characteristics of moisture retention, reduction of skin moisture loss, deep water supplement and capability of keeping skin glossy and elastic.
The Melissa officinalis extract is whole plant extract of Melissa officinalis (Melissa officinalis) belonging to Labiatae, and the Hierochloes Adoratae oil is active ingredient thereof, and has effects of tranquilizing, relieving, resisting anxiety, dispelling pathogenic wind, relieving spasm, resisting bacteria, resisting virus, resisting fungi, resisting tumor, resisting inflammation, resisting oxidation, resisting fat tissue formation, and improving blood sugar tolerance level. Meanwhile, the melissa officinalis extract is proved to have very obvious antibacterial and antiseptic effects, and has synergistic antibacterial effects with sodium nitrite, sodium benzoate, potassium sorbate and the like. Other components of melissa officinalis extracts such as rosmarinic acid, caffeic acid, flavonoids and the like are known to have antibacterial activity against the following bacteria: bacillus subtilis, Bacillus bifidus, Corynebacterium, Escherichia coli, Klebsiella, acidophilus, Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus rhamnosus, Listeria, Pseudomonas aeruginosa, Salmonella enteritidis, Shigella, Staphylococcus aureus, etc., and fungi such as Candida albicans, Aspergillus niger, etc.
Taxus chinensis (Pilger) Rehd.) also known as Taxus chinensis is a plant of the genus Taxus. Taxol contained in taxus chinensis can block cell division, and can also influence a series of important cellular immunity and inflammation activities, including migration, chemotaxis, adhesion and intracellular transportation of cells, and can influence excessive cell proliferation existing in wound surfaces. The taxus chinensis stem cell extract can effectively prevent the generation of superficial scars in the healing process of skin wounds.
The Aloe extract is an extract of leaf of Aloe (Aloe vera L. ver. chinensis (Haw.) Berger) belonging to Liliaceae, and is a colorless transparent brown slightly viscous liquid, and is dried to give yellow fine powder. The anthrone compounds in Aloe have antibacterial, antiinflammatory, toxic materials clearing away, and wound healing effects. Researches show that the aloesin and the aloe-emodin glycoside have the functions of sterilization and inflammation diminishing. Aloin and aloesin have skin beautifying effects, and have certain effects in keeping moisture, relieving inflammation, inhibiting bacteria, relieving itching, resisting allergy, softening skin, preventing acne, inhibiting sweat, and deodorizing.
The inventor finds that when the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are used together, a synergistic effect is generated in the aspect of skin repair, damaged skin can be quickly repaired, wound pain is relieved, scar formation is reduced, wound infection and allergy can be prevented, and a wound can be kept moist.
As a preferred embodiment of the skin care matrix, the weight ratio of the tremella polysaccharide to the melissa officinalis to the taxus chinensis to the aloe extract is 0.01-5: 0.01-5. The tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are compounded according to the proportion, so that the skin repairing effect is good.
As the most preferable embodiment of the skin care matrix of the invention, the weight ratio of the tremella polysaccharide to the melissa officinalis to the taxus chinensis stem cell extract to the aloe extract is 2:3:2: 3. The tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are compounded according to the proportion, so that the skin repairing effect is best.
As a preferred embodiment of the invention, the skin care matrix comprises the following components in parts by weight: 0.01-5 parts of tremella polysaccharide, 0.01-5 parts of melissa officinalis extract, 0.01-5 parts of taxus chinensis stem cell extract, 0.01-5 parts of aloe extract, 0.1-1 part of dipotassium glycyrrhizinate, 0.1-2 parts of panthenol, 0.01-1 part of sodium polyacrylate grafted starch, 1-15 parts of 1, 3-propylene glycol, 0.001-1 part of sodium hyaluronate, 1-15 parts of glycerol and 65-90 parts of water.
As a more preferred embodiment of the present invention, the skin care base comprises the following components in parts by weight: 2-5 parts of tremella polysaccharide, 3-5 parts of melissa officinalis extract, 2-5 parts of taxus chinensis stem cell extract, 3-5 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 65-90 parts of water.
As the most preferred embodiment of the present invention, the skin care base comprises the following components in parts by weight: 2 parts of tremella polysaccharide, 3 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 65-90 parts of water.
As the most preferred embodiment of the invention, the preparation method of the skin care matrix comprises the following steps:
(1) mixing the sodium polyacrylate grafted starch, 1, 3-propylene glycol, sodium hyaluronate, glycerol and water, heating and uniformly stirring to obtain a mixed solution A;
(2) and (3) defoaming the mixed solution A in vacuum, cooling, sequentially adding panthenol, dipotassium glycyrrhizinate, tremella polysaccharide, melissa officinalis extract, taxus chinensis stem cell extract and aloe extract when the temperature is reduced to 30-45 ℃, and uniformly stirring to obtain the skin-care matrix.
As a preferable embodiment of the preparation method of the skin care matrix, in the step (1), the heating temperature is 80-90 ℃, the heat preservation time is 30min, and the stirring speed is 1000-1300 r/min.
As a preferred embodiment of the preparation method of the skin care matrix, in the step (2), the stirring speed is 500-800 r/min, and the stirring time is 30 min.
Furthermore, it is an object of the present invention to provide the use of said skin care base, in particular the use of said skin care base in skin repair. Preferably, the skin care matrix is used in a wound dressing.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are compounded and used in the skin care matrix, and the combination of the four components can generate a synergistic interaction effect, so that the tremella polysaccharide can be efficiently applied to the field of skin repair.
(2) The skin care matrix disclosed by the invention has the effect of quickly repairing damaged skin, also has excellent antibacterial, bactericidal and anti-inflammatory effects and moisturizing effects, can effectively prevent wound surface bacterial infection and skin allergy, keep the wound surface moist, prevent the wound surface from being dry, lack of water and accumulated pus and flowing, can reduce the formation of scar tissue, and has a good application prospect in the aspect of healing of skin wounds.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples. It should be understood that the examples are not intended to limit the scope of the present invention. The raw materials used in the present invention were all commercially available, and the sources of the raw materials used in this example are shown in the following table.
| Raw materials | Purchasing manufacturer |
| Tremella polysaccharide | Korea Kabushiki Kaisha |
| Melissa extract | Clariant chemical Company (CLARIANT) |
| Taxus chinensis stem cell extract | SHANGHAI OLI BIOTECH Co.,Ltd. |
| Aloe extract | De Zhi Xin Co., Ltd (SYMRISE) |
| Glycyrrhizic acid dipotassium salt | Shanghai hong Jiu Enterprise development Co Ltd |
| Panthenol | Huilang group |
| Polysodium polyacrylate grafted starch | Dadonghua (Shanghai) cosmetics science and technology Co., Ltd |
| 1, 3-propanediol | Kesi International trade (Guangzhou) Inc |
| Hyaluronic acid sodium salt | BLOOMAGE FREDA BIOPHARM Co.,Ltd. |
| Glycerol | Youli oil & fat chemical trade (Shanghai) Co Ltd |
Example 1
This example 1 provides a skin care matrix for rapidly repairing skin, where the skin care matrix is composed of the following components in parts by weight: 0.1 part of tremella polysaccharide, 0.1 part of melissa officinalis extract, 0.1 part of taxus chinensis stem cell extract, 0.1 part of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 68 parts of water.
The preparation method of the skin care matrix comprises the following steps:
(1) adding sodium polyacrylate grafted starch, 1, 3-propylene glycol, sodium hyaluronate, glycerol and water into a stirring pot, and stirring for 30min at the temperature of 80-90 ℃ at the speed of 1000-1300 r/min until the materials are uniformly mixed to obtain a mixed solution A;
(2) and (3) defoaming the mixed solution A in vacuum, cooling, adding panthenol, dipotassium glycyrrhizinate, tremella polysaccharide, melissa officinalis extract, taxus chinensis stem cell extract and aloe extract in sequence when the temperature is reduced to 30-45 ℃, and stirring for 30min at a speed of 500-800 r/min until the mixture is uniformly mixed to obtain the skin-care matrix.
Example 2
This example 2 provides a skin care matrix for rapidly repairing skin, where the skin care matrix is composed of the following components in parts by weight: 2 parts of tremella polysaccharide, 1 part of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 1 part of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 75 parts of water. The skin care base was prepared as in example 1.
Example 3
This example 3 provides a skin care matrix for rapidly repairing skin, where the skin care matrix is composed of the following components in parts by weight: 2 parts of tremella polysaccharide, 3 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 80 parts of water. The skin care base was prepared as in example 1.
Example 4
This example 4 provides a skin care matrix for rapidly repairing skin, where the skin care matrix is composed of the following components in parts by weight: 2 parts of tremella polysaccharide, 4 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 4 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 82 parts of water. The skin care base was prepared as in example 1.
Example 5
This example 5 provides a skin care matrix for rapidly repairing skin, wherein the skin care matrix comprises the following components in parts by weight: 4 parts of tremella polysaccharide, 4 parts of melissa officinalis extract, 4 parts of taxus chinensis stem cell extract, 4 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 88 parts of water. The skin care base was prepared as in example 1.
Example 6
This example 6 provides a skin care matrix for rapidly repairing skin, wherein the skin care matrix comprises the following components in parts by weight: 0.01 part of tremella polysaccharide, 0.01 part of melissa officinalis extract, 5 parts of taxus chinensis stem cell extract, 5 parts of aloe extract, 0.1 part of dipotassium glycyrrhizinate, 2 parts of panthenol, 1 part of sodium polyacrylate grafted starch, 15 parts of 1, 3-propylene glycol, 1 part of sodium hyaluronate, 1 part of glycerol and 90 parts of water. The skin care base was prepared as in example 1.
Example 7
This example 7 provides a skin care matrix for rapidly repairing skin, which is composed of the following components in parts by weight: 5 parts of tremella polysaccharide, 5 parts of melissa officinalis extract, 0.01 part of taxus chinensis stem cell extract, 0.01 part of aloe extract, 1 part of dipotassium glycyrrhizinate, 0.1 part of panthenol, 0.01 part of sodium polyacrylate grafted starch, 1 part of 1, 3-propylene glycol, 0.001 part of sodium hyaluronate, 15 parts of glycerol and 65 parts of water. The skin care base was prepared as in example 1.
Comparative example 1
The skin care matrix comprises the following components in parts by weight: 2 parts of tremella polysaccharide, 2 parts of taxus chinensis stem cell extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 80 parts of water. The skin care base was prepared according to example 1.
Comparative example 2
The skin care matrix comprises the following components in parts by weight: 3 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 80 parts of water. The skin care base was prepared according to example 1.
Comparative example 3
The skin care matrix comprises the following components in parts by weight: 2 parts of tremella polysaccharide, 3 parts of melissa officinalis extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 80 parts of water. The skin care base was prepared according to example 1.
Comparative example 4
The skin care matrix comprises the following components in parts by weight: 2 parts of tremella polysaccharide, 3 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 80 parts of water. The skin care base was prepared according to example 1.
Comparative example 5
The skin care matrix comprises the following components in parts by weight: 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 65 parts of water. The skin care base was prepared according to example 1.
Product performance testing
1. Product antibacterial property test
The skin care bases of examples 1-7 and comparative examples 1-5 were tested for antibacterial activity.
The method comprises the following steps: the test bacteria to be cultured are inoculated into 5-20 mL of nutrient culture solution and cultured for 18-24 hours at 37 ℃. And then, carrying out ten-fold dilution method on the cultured bacterial liquid to obtain the number of cultured strains.
Placing the object to be tested on a culture dish, dripping culture bacteria liquid, then placing the object to be tested in an incubator at 37 ℃ for 18 hours of culture, then calculating the number of propagated colonies and calculating the sterilization rate in a sample, and the antibacterial effect of the product can be estimated according to the sterilization rate.
The sterilization rate (%) [ (Ma-Mb)/Ma ] × 100%
And Ma: the contact time t of the sample and the bacterial liquid is 0 hour;
mb: the number of colonies of the sample in contact with the bacterial solution for t hours.
(Staphylococcus aureus) (t ═ 18h, volume of analyte 10ml)
The test results are given in the following table:
| group of | Sterilization (%) |
| Example 1 | 80 |
| Example 2 | 90 |
| Example 3 | 96 |
| Example 4 | 96 |
| Example 5 | 98 |
| Example 6 | 82 |
| Example 7 | 85 |
| Comparative example 1 | 65 |
| Comparative example 2 | 70 |
| Comparative example 3 | 68 |
| Comparative example 4 | 66 |
| Comparative example 5 | 15 |
The results in the table show that the skin care bases prepared in the examples all have better antibacterial performance than the comparative examples, wherein the effect of example 5 is the best, and then example 3 and example 4. Comparing example 3 with comparative example 5, it can be seen that the addition of Tremella polysaccharides, Melissa officinalis extract, Taxus chinensis Stem cell extract and Aloe vera extract can significantly improve the antibacterial properties of the skin care matrix. Comparing example 3 with comparative examples 1 to 4, it can be seen that when the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract are used together, a synergistic effect is generated, so that the antibacterial property of the skin care matrix is stronger, and when the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract or the aloe extract is absent, the antibacterial property of the skin care matrix is reduced.
2. Evaluation of product efficacy
The skin care matrices prepared in the examples and comparative examples were used in clinical trials, and 220 patients from hospital after minimally invasive surgery were tried out. The adverse reactions in the recovery period after minimally invasive surgery mainly include symptoms such as red swelling, pain, erythema, exudation, edema, pigmentation, superficial scars and even infection, and the adverse reactions after the recovery period of trauma are symptoms such as skin darkness and scars. The experiment is mainly aimed at four items of redness and swelling and exudation in the postoperative recovery period and skin pigmentation and scars after the postoperative recovery period, and the evaluation of symptom integral values is carried out, wherein the symptom integral values are evaluated by a four-stage scoring method and are respectively counted as 1, 2, 3 and 4 in terms of lightness, middle, weight and severity. The trial objects are evenly divided into 11 groups, 20 persons in each group use the skin care matrixes prepared in the examples 1-7 and the comparative examples 1-4 respectively, the skin care matrixes are directly coated on the wounds for 2 times a day and are continuously used for 30 days, other variable factors are strictly controlled during the trial period, and the results are recorded in detail.
The therapeutic effect criteria are as follows: the effect is shown: the symptom integral value is reduced by over 71 percent; the method has the following advantages: the symptom integral value is reduced by 35 to 70 percent; and (4) invalidation: the integral value of symptoms is reduced by 35% or less.
The test evaluation results are as follows:
| group of | Red swelling and pain | Oozing out | Pigmentation of the skin | Scar formation |
| Example 1 | 90％ | 90.5％ | 91.2％ | 91％ |
| Example 2 | 92％ | 93.7％ | 92.9％ | 93.5％ |
| Example 3 | 95％ | 95.6％ | 96.2％ | 96.1％ |
| Example 4 | 95.2％ | 96.0％ | 96％ | 96.5％ |
| Example 5 | 96.3％ | 95.8％ | 96.5％ | 96.7％ |
| Example 6 | 90.5％ | 91％ | 92％ | 91.3％ |
| Example 7 | 91.3％ | 92.4％ | 92.5％ | 92.2％ |
| Comparative example 1 | 84％ | 83％ | 81.2％ | 80.3％ |
| Comparative example 2 | 82.6％ | 81％ | 81％ | 82％ |
| Comparative example 3 | 80.4％ | 82％ | 80.8％ | 81％ |
| Comparative example 4 | 80.7％ | 78.6％ | 79.3％ | 81.9％ |
The results in the table show that the skin care matrix prepared in the example can obviously reduce the red swelling and exudation in the wound recovery period and the skin pigmentation and scar symptoms after the wound recovery period, so that the wound can be rapidly repaired, and the effect is better than that of the comparative example. Comparing the example 3 with the comparative examples 1 to 4, it can be seen that the effect of the skin care matrix is reduced when any one of the four effective components, namely the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe extract is absent, and the skin repair effect of the skin care matrix can be further provided when the four effective components are used together. In addition, the effect of the skin care base is gradually improved with the increase of the dosage of the four effective components of the tremella polysaccharide, the melissa officinalis extract, the taxus chinensis stem cell extract and the aloe vera extract, but the results of the examples 3, 4 and 5 are not greatly different, and the example 3 is preferred in consideration of the effect and the cost. According to statistics, patients using the skin care matrix of the embodiment have no adverse reaction.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. The skin care matrix is characterized by comprising the following components in parts by weight: 0.01-5 parts of tremella polysaccharide, 0.01-5 parts of melissa officinalis extract, 0.01-5 parts of taxus chinensis stem cell extract, 0.01-5 parts of aloe extract, 0.1-1 part of dipotassium glycyrrhizinate, 0.1-2 parts of panthenol, 0.01-1 part of sodium polyacrylate grafted starch, 1-15 parts of 1, 3-propylene glycol, 0.001-1 part of sodium hyaluronate, 1-15 parts of glycerol and 65-90 parts of water.
2. The skin care base according to claim 1, wherein the weight ratio of the tremella polysaccharide to the melissa officinalis to the taxus chinensis stem cell extract to the aloe vera extract is 2:3:2: 3.
3. The skin care matrix of claim 1 comprising the following components in parts by weight: 2-5 parts of tremella polysaccharide, 3-5 parts of melissa officinalis extract, 2-5 parts of taxus chinensis stem cell extract, 3-5 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 65-90 parts of water.
4. The skin care matrix of claim 3 comprising the following components in parts by weight: 2 parts of tremella polysaccharide, 3 parts of melissa officinalis extract, 2 parts of taxus chinensis stem cell extract, 3 parts of aloe extract, 0.5 part of dipotassium glycyrrhizinate, 1 part of panthenol, 0.3 part of sodium polyacrylate grafted starch, 8 parts of 1, 3-propylene glycol, 0.5 part of sodium hyaluronate, 10 parts of glycerol and 65-90 parts of water.
5. A method of making a skin care base according to any one of claims 1 to 4 comprising the steps of:
(1) mixing the sodium polyacrylate grafted starch, 1, 3-propylene glycol, sodium hyaluronate, glycerol and water, heating and uniformly stirring to obtain a mixed solution A;
(2) and (3) defoaming the mixed solution A in vacuum, cooling, sequentially adding panthenol, dipotassium glycyrrhizinate, tremella polysaccharide, melissa officinalis extract, taxus chinensis stem cell extract and aloe extract when the temperature is reduced to 30-45 ℃, and uniformly stirring to obtain the skin-care matrix.
6. The method for preparing a skin care base according to claim 5, wherein in the step (1), the heating temperature is 80-90 ℃, the heat preservation time is 30min, and the stirring speed is 1000-1300 r/min.
7. The method of preparing a skin care base according to claim 5, wherein in the step (2), the stirring speed is 500 to 800r/min and the stirring time is 30 min.
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| CN101543467A (en) * | 2009-04-01 | 2009-09-30 | 完美（中国）日用品有限公司 | Aloe gel and preparation method thereof |
| CN106726943A (en) * | 2016-12-19 | 2017-05-31 | 广州睿森生物科技有限公司 | Cosmetic composition, invisible face pack for damaged skin protection and repair and preparation method thereof |
| CN108210887A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of Medical cold application and preparation method thereof |
| CN108210982A (en) * | 2016-12-22 | 2018-06-29 | 南通蓝智新材料科技有限公司 | Wound repair dressing and its preparation method and application |
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| DK2296676T3 (en) * | 2008-05-09 | 2016-12-19 | Regenics As | cellular extracts |
| WO2016210074A1 (en) * | 2015-06-23 | 2016-12-29 | Carrie D. Alspaugh, M.D., P.A. | Hand sanitizing compositions |
| CN106606798A (en) * | 2016-12-07 | 2017-05-03 | 武汉医佳宝生物材料有限公司 | Medical hyaluronic acid bioremediation plaster and preparation method thereof |
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| CN101543467A (en) * | 2009-04-01 | 2009-09-30 | 完美（中国）日用品有限公司 | Aloe gel and preparation method thereof |
| CN106726943A (en) * | 2016-12-19 | 2017-05-31 | 广州睿森生物科技有限公司 | Cosmetic composition, invisible face pack for damaged skin protection and repair and preparation method thereof |
| CN108210982A (en) * | 2016-12-22 | 2018-06-29 | 南通蓝智新材料科技有限公司 | Wound repair dressing and its preparation method and application |
| CN108210887A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of Medical cold application and preparation method thereof |
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