CN109394566A - A kind of facial mask essence for repairing blue light damage - Google Patents
A kind of facial mask essence for repairing blue light damage Download PDFInfo
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- CN109394566A CN109394566A CN201811559355.9A CN201811559355A CN109394566A CN 109394566 A CN109394566 A CN 109394566A CN 201811559355 A CN201811559355 A CN 201811559355A CN 109394566 A CN109394566 A CN 109394566A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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Abstract
A kind of facial mask essence for repairing blue light damage, it is by purified water, allantoin, dipropylene glycol, methyl gluceth -20, PPG-24- glycerin polyether -24, EDETATE SODIUM, fragrant fresh ketone, 1,2- hexylene glycol, carbomer, arginine, Sodium Hyaluronate, hydroxyethyl cellulose, hydroxylated lecithin, creatine, carnosine and transparent ceramide inclusion enclave composition, it has to the skin after blue light illumination with repair.
Description
Technical field
This patent is related to a kind of facial mask essence of reparation blue light damage, belongs to cosmetic technical field.
Technical background
It is well known that protection skin will avoid UVB, UVA and IR ray extremely important, but comparatively how skin copes with
It can be seen that light injury, especially high energy visible light-blue light then have kind of an ignored feeling.The wavelength of blue light connects between 400-500nm
Near ultraviolet is the shortest high-energy visible light of wavelength, also referred to as high energy visible light (High Energy Visible Light,
HEVL).Artificial blue light includes artificial light source: for energy-efficient fluorescent lamp bulb, LED light and electronic equipment such as mobile phone, plate and
Computer, TV.Recent studies suggest that there is also harmful one sides for blue light, signified blue light contamination, which refers to, at present is exposed to " hyperlink
Connect life style " artificial blue light.As be persistently exposed under blue light just before going to bed with it is sleep disordered, epiphysin is not normal and eye early ageing
It is related, also referred to as " blue light harm ".1) influence of visible light or high energy visible light HEV to Skin Cell, which specifically includes that, to be increased
Add active oxygen, induced skin oxidative damage, 2) promote inflammatory factor secretion, cascade of response of inflammation is induced, skin aging is accelerated,
3) delay epidermal barrier reparation, 4) mitochondrial DNA damage, 5) consume carotenoid in skin corium.Research shows that by 2020
It is expected that increasing by 53% smart phone user.60% people spends at least 6h on a digital device daily, therefore we expose daily
Time under blue light considerably beyond the time for being directly subjected to UV radiation.At present in China, " 3C is early for the hot spot of consumer's concern
Decline " it include Cities (air pollution), Computers (blue light) and Communications (wireless radiation).Therefore, it develops
Have effects that repair the cosmetic material that damages of blue light or cosmetics finished product is very necessary.
Repair blue light damage mainly from enhancing blue light illumination after organizational vitality, mitigate blue light illumination after tissue damage and
Three aspect of oxide after confrontation blue light illumination.Creatine (creatine) is that a kind of one kind being naturally occurring in vertebrate body contains
The organic acid of nitrogen can assist providing energy for muscle and nerve cell.It can quickly provide energy, the Activities of human body
It is by ATP, i.e., atriphos provides energy, and ATP is very few in the intracorporal amount of storage of people, and when movement, ATP disappears soon
Totally, at this moment creatine can synthesize ATP again quickly to supply energy to consumption.Blue light can be effectively increased in facial mask using creatine
The organizational vitality of cell after damage.
Carnosine can be removed by a kind of dipeptides being made of two kinds of amino acid of Beta-alanine and L-Histidine in oxidative stress
The active oxygen radical for making the fatty acid excessive oxidation of cell membrane in the process and being formed.
Ceramide forms sphingoin matter one kind by sphingosine long chain base and fatty acid.Ceramide
(Ceramide) it is a kind of phosphatide using ceramide as skeleton, mainly there is ceramide phosphocholine and ceramide phosphoric acid second
Hydramine, phosphatide are the main components of cell membrane, and the sebum of 40%-50% is made of ceramide in cuticula, and ceramide is
The major part of intercellular matrix plays an important role in the balance for keeping cuticula moisture.But ceramide is in cosmetics
In be easy crystallization be precipitated, influence both effectiveness and stability.Ceramide in the present invention using the Semen Tritici aestivi extract containing 2% is saturating
Bright inclusion enclave.Sugared sheath ester and digalactosyl diglyceride are mainly contained in Semen Tritici aestivi extract, are played stable ceramide and are being made up
Stability in product and both effectiveness.
Summary of the invention
Object of the present invention is to develop a kind of facial mask essence of reparation blue light damage, it has to the skin after blue light illumination
With repair.
A kind of facial mask essence for repairing blue light damage, which is characterized in that formulation weight proportion is as follows:
Purified water: 69.5%-85%,
Allantoin: 0.1%-0.2%,
Dipropylene glycol: 5%-10%,
Methyl gluceth -20:0.5%-1%,
PPG-24- glycerin polyether -24:0.5%-1%,
EDETATE SODIUM: 0.02%-0.1%,
Fragrant fresh ketone: 0.3%-0.6%,
1,2- hexylene glycol: 0.3%-0.6%,
Carbomer: 0.1%-0.2%,
Arginine: 0.1%-0.2%,
Sodium Hyaluronate: 0.01%-0.1%,
Hydroxyethyl cellulose: 0.01%-0.1%,
Hydroxylated lecithin: 0.1%-0.2%,
Creatine: 0.3%-0.8%,
Carnosine: 0.1%-0.4%,
Transparent ceramide inclusion enclave: 8%-15%,
The sum of above each raw material weight percentage is 100%.
A kind of facial mask essence of reparation blue light damage, wherein carnosine chemical formula is β-alanyl-L- group ammonia
Acid.
The facial mask essence of a kind of reparation blue light damage, wherein transparent ceramide is package Cer NS, mind
Through amide 3 and Cer AP partial size 10-20nm ceramide inclusion enclave.
A kind of facial mask essence of reparation blue light damage, transparent ceramide, wherein being containing weight percent
2% Semen Tritici aestivi extract.
Detailed description of the invention
Fig. 1 is organizational capacity effect picture of the present invention.
Specific embodiment
The present invention is further illustrated below by specific embodiment, reference examples, it is to be understood that, it is these embodiments, right
It is only used for specifically describing in more detail as usual being used, but should not be understood as present invention is limited in any form.
Embodiment 1
A kind of facial mask essence for repairing blue light damage, weight proportion are as follows:
Purified water: 69.5%-85%
Allantoin: 0.1%
Dipropylene glycol: 5%
Methyl gluceth -20:0.5%
PPG-24- glycerin polyether -24:0.5%
EDETATE SODIUM: 0.02%
Fragrant fresh ketone: 0.3%
1,2- hexylene glycol: 0.3%
Carbomer: 0.1%
Arginine: 0.1%
Sodium Hyaluronate: 0.01%
Hydroxyethyl cellulose: 0.01%
Hydroxylated lecithin: 0.1%
Creatine: 0.3%
Carnosine: 0.1%
Transparent ceramide inclusion enclave: 8%
The preparation method of embodiment 1:
1. dipropylene glycol is added in carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin
In, it stirs evenly；
2. purified water is added to be added in the mixture of step 1, stirring to grainless state；
3. arginine is stirred to viscous liquid state；
4. addition methyl gluceth -20, PPG-24- glycerin polyether -24,1,2- hexylene glycol, creatine, carnosine are transparent
Ceramide inclusion enclave and hydroxylated lecithin, stir evenly, discharging.
Embodiment 2
A kind of facial mask essence for repairing blue light damage, weight proportion are as follows:
Purified water: 69.5%-85%
Allantoin: 0.15%
Dipropylene glycol: 7.5%
Methyl gluceth -20:0.75%
PPG-24- glycerin polyether -24:0.75%
EDETATE SODIUM: 0.05%
Fragrant fresh ketone: 0.5%
1,2- hexylene glycol: 0.5%
Carbomer: 0.15%
Arginine: 0.15%
Sodium Hyaluronate: 0.05%
Hydroxyethyl cellulose: 0.05%
Hydroxylated lecithin: 0.15%
Creatine: 0.5%
Carnosine: 0.25%
Transparent ceramide inclusion enclave: 12%；
The preparation method of embodiment 2:
1. dipropylene glycol is added in carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin
In, it stirs evenly；
2. purified water is added to be added in the mixture of step 1, stirring to grainless state；
3. arginine is stirred to viscous liquid state；
4. addition methyl gluceth -20, PPG-24- glycerin polyether -24,1,2- hexylene glycol, creatine, carnosine are transparent
Ceramide inclusion enclave and hydroxylated lecithin, stir evenly, discharging；
Embodiment 3
A kind of facial mask essence for repairing blue light damage, weight proportion are as follows: purified water: 69.5%-85%
Allantoin: 0.20%
Dipropylene glycol: 10%
Methyl gluceth -20:1%
PPG-24- glycerin polyether -24:1%
EDETATE SODIUM: 0.1%
Fragrant fresh ketone: 0.6%
1,2- hexylene glycol: 0.6%
Carbomer: 0.20%
Arginine: 0.20%
Sodium Hyaluronate: 0.10%
Hydroxyethyl cellulose: 0.10%
Hydroxylated lecithin: 0.20%
Creatine: 0.8%
Carnosine: 0.4%
Transparent ceramide inclusion enclave: 15%
The preparation method of embodiment 3:
1. dipropylene glycol is added in carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin
In, it stirs evenly；
2. purified water is added to be added in the mixture of step 1, stirring to grainless state；
3. arginine is stirred to viscous liquid state；
4. addition methyl gluceth -20, PPG-24- glycerin polyether -24,1,2- hexylene glycol, creatine, carnosine are transparent
Ceramide inclusion enclave and hydroxylated lecithin, stir evenly, discharging；
Comparative example 1
A kind of facial mask essence for repairing blue light damage, weight proportion are as follows:
Purified water: 69.5%-85%
Allantoin: 0.20%
Dipropylene glycol: 10%
Methyl gluceth -20:1%
PPG-24- glycerin polyether -24:1%
EDETATE SODIUM: 0.1%
Fragrant fresh ketone: 0.6%
1,2- hexylene glycol: 0.6%
Carbomer: 0.20%
Arginine: 0.20%
Sodium Hyaluronate: 0.10%
Hydroxyethyl cellulose: 0.10%
Hydroxylated lecithin: 0.20%
The preparation method of comparative example 1:
1. dipropylene glycol is added in carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin
In, it stirs evenly；
2. purified water is added to be added in the mixture of step 1, stirring to grainless state；
3. arginine is stirred to viscous liquid state；
4. methyl gluceth -20, PPG-24- glycerin polyether -24 are added, stir evenly, discharges；
4 groups of compositions of above-mentioned preparation are utilized into 3D epidermis model (Epikutis), the effect of blue light damage is repaired in test.
The specific test method is as follows:
Preparation based on EpiKutis blue light damage model: the skin model Epikutis after recovery is turned according to grouping
It moves in 24 orifice plates containing model culture solution.It draws 25 μ L embodiment 1-3 respectively using pipettor and comparative example 1 is added on skin
Skin model surface is placed in continuous irradiation 8h under blue-ray light, modal distance fluorescent tube height about 5cm in superclean bench.Irradiation knot
Shu Hou, using the tested material of cotton swab model surface, cotton swab dries surface moisture content, and by the skin model after cleaning, (every group takes 3
It is a) it is transferred in 6 orifice plates, 0.9mL culture solution is added in every hole, is placed in 37 DEG C, the incubator of 5%CO2 and 95% relative humidity
In, it is incubated for 16h.
The test grouping of table 1
Organizational vitality measurement based on EpiKutis blue light damage model: every in 24 sterile orifice plates after the completion of incubation
The MTT working solution (1mg/mL) of 300 μ L is added in hole, and cotton swab is dried bottom surface culture solution residual, is then transferred to by label containing MTT
In 24 orifice plates of working solution.It is placed in 37 DEG C, in the incubator of 5%CO2 and 95% relative humidity, is incubated for 3h ± 5min.MTT is incubated
After the completion of educating, MTT solution is sucked using pipette tips are soft from orifice plate.It to DPBS solution is added in orifice plate, sucks, repeats again
This cleaning process totally 3 times, it is ensured that organize to dry out when sucking for the last time.After washing, tissue bottom surface is wiped with blotting paper
It is dry, it is transferred in 24 new orifice plates, 2mL isopropanol, the crystallization that dissolution MTT is generated is added in culture cell.Using sealed membrane
Sealing 24 hole sheet separations avoids isopropanol volatilization from influencing final volume.4 DEG C stand overnight dissolution.After the completion of dissolution, using 200 μ L rifles
Head pierces through tissue, flows to dissolved matter in culture hole from tissue.Pierced tissue is abandoned, piping and druming is molten up and down in culture hole
Ensure that solution is uniform liquid at least 3 times.Measurement OD value is read in wavelength 570nm with 96 orifice plates, using isopropanol as blank control.
Tectology detection based on EpiKutis blue light damage model: (every group of skin model after cleaning will be incubated for
Take 3) under scalpel ring cutting, it is transferred in 1.5mL EP pipe, neutral formalin fixer is added and fixes for 24 hours, gradient second
Dehydration of alcohols, dimethylbenzene is transparent, and routine paraffin wax embedding carries out H&E dyeing after slice is made.It takes pictures under microscope observation, acquisition figure
Piece.
Superoxide dismutase SOD vigor: collecting the model (every group takes 6) after being incubated for cleaning, and 300 μ L albumen are added and mention
Liquid is taken, after piping and druming uniformly, collects upper layer protein solution.Concentration mensuration is carried out using BCA protein reagent box.It measures and tries according to SOD
Agent box specification is measured the SOD vigor of each group sample.
Experimental result:
Organizational vitality: as shown in figure, compared with blank control group, the organizational vitality of negative control group is remarkably decreased, and
Positive controls significantly rise compared to organizational vitality compared with negative control group, it was demonstrated that cell tissue vigor can be bright after blue light illumination
Aobvious decline, and illustrate this time to test effective.It can be seen from Fig. 1 that organizational vitality remains basically stable with negative control in comparative example 1, say
Bright, comparative example 1 has no repair under blue light illumination, and embodiment 1-3 organizational vitality comparison negative control group significantly rises
And with the increase of creatine, carnosine and transparent ceramide inclusion enclave weight percent, organizational vitality also increase accordingly, says
Bright creatine, carnosine and transparent ceramide inclusion enclave have repair to the skin after blue light illumination；
Tectology detection: compared with blank group BC, negative control group NC living cells layer number is reduced, living cells layer born of the same parents
Core is largely shunk, and tissue morphology is abnormal, and Sunburn Cell (at arrow) quantity increases；It is positive compared with negative control group NC
Control group PC living cells layer number increases, and living cells layer karyon shrinking percentage reduces, and Sunburn Cell quantity is reduced, with blank group
There was no significant difference for structure compared, illustrates that this experiment is effective.Compared with negative control group NC, embodiment 1-3 Sunburn
Cell quantity is reduced, and living cells layer number is more compared with negative control group NC, and living cells layer karyon shrinking percentage is low, and tissue morphology is extensive
It is multiple.Comparative example 1 is with negative control group NC living cells layer number and living cells layer karyon shrinking percentage with negative control group NC without obvious
Difference.Skin after illustrating embodiment 1-3 blue light illumination has repair；
Superoxide dismutase SOD vigor: with blank group BC ratio, negative control group NC SOD vigor is significantly reduced；With yin
Property control group NC compare, positive controls PCSOD vigor significantly rises, it was demonstrated that this experiment is effective.With negative control group NC phase
Than the SOD vigor of embodiment 1-3 significantly rises.Skin after illustrating embodiment 1-3 blue light illumination has repair.
Claims (4)
1. a kind of facial mask essence for repairing blue light damage, which is characterized in that formulation weight proportion is as follows:
Purified water: 69.5%-85%,
Allantoin: 0.1%-0.2%,
Dipropylene glycol: 5%-10%,
Methyl gluceth -20:0.5%-1%,
PPG-24- glycerin polyether -24:0.5%-1%,
EDETATE SODIUM: 0.02%-0.1%,
Fragrant fresh ketone: 0.3%-0.6%,
1,2- hexylene glycol: 0.3%-0.6%,
Carbomer: 0.1%-0.2%,
Arginine: 0.1%-0.2%,
Sodium Hyaluronate: 0.01%-0.1%,
Hydroxyethyl cellulose: 0.01%-0.1%,
Hydroxylated lecithin: 0.1%-0.2%,
Creatine: 0.3%-0.8%,
Carnosine: 0.1%-0.4%,
Transparent ceramide inclusion enclave: 8%-15%,
The sum of above each raw material weight percentage is 100%.
2. a kind of facial mask essence for repairing blue light damage according to claim 1, wherein carnosine chemical formula is β-the third ammonia
Acyl group-L-Histidine.
3. a kind of facial mask essence for repairing blue light damage according to claim 1, wherein transparent ceramide is package
The ceramide inclusion enclave of Cer NS, Cer NP and Cer AP partial size in 10-20nm.
4. a kind of facial mask essence for repairing blue light damage according to claim 3, transparent ceramide, wherein containing weight
Measure the Semen Tritici aestivi extract that percentage is 2%.
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| CN201811559355.9A CN109394566B (en) | 2018-12-19 | 2018-12-19 | Mask essence for repairing blue light damage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811559355.9A CN109394566B (en) | 2018-12-19 | 2018-12-19 | Mask essence for repairing blue light damage |
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| CN109394566B CN109394566B (en) | 2021-10-08 |
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ID=65460028
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114948789A (en) * | 2022-05-10 | 2022-08-30 | 珠海冀百康生物科技有限公司 | SOD composition with high-efficiency blue light resisting effect and preparation method thereof |
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| CN114948789A (en) * | 2022-05-10 | 2022-08-30 | 珠海冀百康生物科技有限公司 | SOD composition with high-efficiency blue light resisting effect and preparation method thereof |
| CN114948789B (en) * | 2022-05-10 | 2023-07-25 | 珠海冀百康生物科技有限公司 | SOD composition with blue light resisting effect and preparation method thereof |
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| CN109394566B (en) | 2021-10-08 |
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