CN108904399A - It is a kind of to remove acarid, cleaning solution of reparation skin and preparation method thereof - Google Patents
It is a kind of to remove acarid, cleaning solution of reparation skin and preparation method thereof Download PDFInfo
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- CN108904399A CN108904399A CN201811187985.8A CN201811187985A CN108904399A CN 108904399 A CN108904399 A CN 108904399A CN 201811187985 A CN201811187985 A CN 201811187985A CN 108904399 A CN108904399 A CN 108904399A
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- acarid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
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- Pest Control & Pesticides (AREA)
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- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
The present invention relates to a kind of removing acarids, the cleaning solution for repairing skin and preparation method thereof.The cleaning solution removed acarid, repair skin includes the raw material of following parts by weight：65~75 parts of distilled water, 15~25 parts of propylene glycol, 1~3 part of glycerol, 1~3 part of Radix Gentianae extract, 0.5~1.5 part of pericarpium zanthoxyli schinifolii extract, 0.25~0.75 part of clary active peptide and 0.25~0.75 part of lavender plant active peptides.The cleaning solution can kill bacterium, acarid, and firm skin adjusts mental emotion, and maintains the cleaning of skin, and effect is long-acting persistently.The preparation method only needs to mix each raw material substep, and technique is easy to control, is conducive to large-scale production.
Description
Technical field
The invention belongs to skin care fields, and in particular to a kind of to remove acarid, cleaning solution of reparation skin and preparation method thereof.
Background technique
The growth of face mite often leads to the impaired of skin, such as：Epifolliculitis, seborrhea, blear-eye, acne and wine
Slag nose etc..Acarid multiparasitization draws intracellular nutritional substance and smegma object, in pilosebaceous follicle so as to cause normal
The breakage of cell.And the chemical irritation effect of the mechanical stimulus and polypide excreta due to polypide, parasitic site can cause hair
The symptoms such as capsule expansion, blood vessel dilatation, peripheral cell infiltration, proliferation of fibrous tissue.Simultaneously face mite active degree with mood,
The variation of the factors Characteristic fluctuation such as diet, health and menstrual cycle, therefore many factors need to be comprehensively considered by eradicating acarid.
The patent of Publication No. CN107661281A proposes a kind of except face oil, the Cleansing Foam of mite killing worm, and effective component includes
Jasmine wall cell disruption powder, attapulgite wall cell disruption powder, egg white and black sesame paste, the Cleansing Foam can deoil anti-mite.But it is formulated
Design ignores the lasting degree of the factor and effect that can reduce acarid active degree.
Summary of the invention
Of the existing technology in order to solve the problems, such as, the present invention provides a kind of removing acarids, the cleaning solution of reparation skin
And preparation method thereof.The cleaning solution can kill bacterium, acarid, and firm skin adjusts mental emotion, and maintains the clear of skin
It is clean, and effect is long-acting persistently.The preparation method only needs to mix each raw material substep, and technique is easy to control, is conducive to scale
Metaplasia produces.
The solution of the present invention is to provide a kind of cleaning solution removed acarid, repair skin, the original including following parts by weight
Material：65~75 parts of distilled water, 15~25 parts of propylene glycol, 1~3 part of glycerol, 1~3 part of Radix Gentianae extract, pericarpium zanthoxyli schinifolii extract 0.5
~1.5 parts, 0.25~0.75 part of clary active peptide and 0.25~0.75 part of lavender plant active peptides.
Preferably, the described cleaning solution removed acarid, repair skin further includes the preservative that parts by weight are 0.1~0.5 part.
Preferably, the preservative is the mixture of fatty acid glyceride, decoyl hydroximic acid and parahydroxyacet-ophenone.
Preferably, the weight ratio of the fatty acid glyceride, decoyl hydroximic acid and parahydroxyacet-ophenone is 1：1~2：
1~2.
Preferably, the described cleaning solution removed acarid, repair skin includes the raw material of following parts by weight：70 parts of distilled water,
20 parts of propylene glycol, 2 parts of glycerol, 2 parts of Radix Gentianae extract, 1 part of pericarpium zanthoxyli schinifolii extract, 0.5 part of clary active peptide, lavender
0.5 part of plant active peptides, 0.05 part of fatty acid glyceride, 0.1 part of decoyl hydroximic acid and 0.1 part of parahydroxyacet-ophenone.
The conductivity size of distilled water and the wherein general correlation of content of mineral substances, to avoid distilled water Minerals
The influence of confrontation product stability is verified repeatedly through inventor, it is preferable that conductivity≤0.1mS/m of the distilled water.
The present invention also provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
(1) distilled water, propylene glycol and pericarpium zanthoxyli schinifolii extract are mixed and heated heat preservation, obtain mixture a；
(2) mixture a is cooled down, and surplus stock is added and stirs evenly.
Preferably, in step (1), the temperature of the heating is 80~90 DEG C, and the time of heat preservation is 25~35min.
Preferably, described to be cooled to 40~50 DEG C in step (2).
Preferably, in step (2), the revolving speed of the stirring is 15~25r/min, and the time of stirring is 20~30min.
The present invention also provides the application methods of a kind of removing acarid, the cleaning solution for repairing skin：After face cleaning, by the cleaning
Liquid is uniformly applied to face, pats to fully absorbing.
Beneficial effects of the present invention are：
1, the cleaning solution of the present invention removed acarid, repair skin, containing plurality of active ingredients, wherein：Rough gentian mentions
It takes object and clary active peptide that there is antibacterial, the antibacterial action of wide spectrum, is able to maintain the cleaning of skin environment；It is equipped with blueness again
To kill acarid, and during sterilization, deinsectization, skin inevitably generates sense of discomfort to pepper extract, and pericarpium zanthoxyli schinifolii extract is also
There is antalgesic-antipruritic effect, issuable pruritis can be alleviated；In view of acarid is generally originated between dermatoglyph, therefore
Addition has effects that shrink the lavender plant active peptides of skin, to pore refining, smooth skin, can both repair acarid growth
It is damaged caused by skin in the process, and compressible acarid living space, in addition, the aromatic odor energy of lavender plant active peptides
It enough releives pressure, calms down mood, the active degree of acarid can be reduced；And the addition of propylene glycol and glycerol can reduce the table of system
Face tension, so that cleaning solution is more bonded with skin, effect is more lasting.To sum up gained, the cleaning solution can kill bacterium,
Acarid, firm skin adjust mental emotion, and maintain the cleaning of skin, and effect is long-acting persistently.
2, the preparation method of the cleaning solution of the present invention removed acarid, repair skin, it is only necessary to which each raw material substep is mixed
Conjunction, technique is easy to control, is conducive to large-scale production.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
It (1) is that 0.08mS/m distilled water, 250g propylene glycol and 5g pericarpium zanthoxyli schinifolii extract are mixed and heated by 650g conductivity
To 80 DEG C and 35min is kept the temperature, obtains mixture a；
(2) mixture a is cooled to 40 DEG C, and 10g glycerol, 30g Radix Gentianae extract, 7.5g clary activity is added
Peptide and 2.5g lavender plant active peptides mix 30min under the stirring rate of 15r/min.
Embodiment 2
The present embodiment provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
It (1) is that 0.06mS/m distilled water, 150g propylene glycol and 15g pericarpium zanthoxyli schinifolii extract are mixed and heated by 750g conductivity
To 90 DEG C and 25min is kept the temperature, obtains mixture a；
(2) mixture a is cooled to 50 DEG C, and 30g glycerol, 10g Radix Gentianae extract, 2.5g clary activity is added
Peptide and 7.5g lavender plant active peptides mix 20min under the stirring rate of 25r/min.
Embodiment 3
The present embodiment provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
It (1) is that 0.09mS/m distilled water, 250g propylene glycol and 5g pericarpium zanthoxyli schinifolii extract are mixed and heated by 650g conductivity
To 80 DEG C and 35min is kept the temperature, obtains mixture a；
(2) mixture a is cooled to 40 DEG C, and 10g glycerol, 30g Radix Gentianae extract, 7.5g clary activity is added
Peptide, 2.5g lavender plant active peptides, 1g fatty acid glyceride, 2g decoyl hydroximic acid and 2g parahydroxyacet-ophenone, in 15r/min
Stirring rate under mix 30min.
Embodiment 4
The present embodiment provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
It (1) is that 0.06mS/m distilled water, 150g propylene glycol and 15g pericarpium zanthoxyli schinifolii extract are mixed and heated by 750g conductivity
To 90 DEG C and 25min is kept the temperature, obtains mixture a；
(2) mixture a is cooled to 50 DEG C, and 30g glycerol, 10g Radix Gentianae extract, 2.5g clary activity is added
Peptide, 7.5g lavender plant active peptides, 0.33g fatty acid glyceride, 0.33g decoyl hydroximic acid and 0.34g parahydroxyacet-ophenone,
20min is mixed under the stirring rate of 25r/min.
Embodiment 5
The present embodiment provides the preparation methods of a kind of removing acarid, the cleaning solution for repairing skin, include the following steps：
It (1) is that 0.06mS/m distilled water, 200g propylene glycol and 10g pericarpium zanthoxyli schinifolii extract are mixed and heated by 700g conductivity
To 90 DEG C and 25min is kept the temperature, obtains mixture a；
(2) mixture a is cooled to 50 DEG C, and 20g glycerol, 20g Radix Gentianae extract, 5g clary activity is added
Peptide, 5g lavender plant active peptides, 0.5g fatty acid glyceride, 1g decoyl hydroximic acid and 1g parahydroxyacet-ophenone, in 25r/min
Stirring rate under mix 20min.
With reference to GB 27951-2011, the cleaning solution removed acarid, repair skin resulting to Examples 1 to 5 carries out quality
Evaluation, performance rating include 5 aspects：Sensory properties, kills microbiological indicator, security requirement and stability at physical and chemical index.
Evaluation sensory properties method be：It is checked with visual method and removes acarid obtained by Examples 1 to 5, repairs skin
The color and clarity of cleaning solution.
The detection method of physical and chemical index is：The cleaning solution removed acarid obtained by detection Examples 1 to 5 respectively, repair skin
The content of middle lead, mercury and arsenic, three's content are limited to lead < 40mg/L, mercury < 1mg/L, arsenic < 10mg/L.
Kill microbiological test method be：It presses《Disinfection technology standard》Method is measured.Microorganism is killed to refer to
Mark is as shown in table 1.
Table 1 kills microbiological indicator
Security requirement detection method is：It presses《Disinfection technology standard》Method is measured.Detection project is acute
Oral toxicity test, an intact skin irritant test, damaged skin irritant test, acute eye irritation test, skin metamorphosis examination
It tests and mutagenicity test.
Detection of Stability requirement：It is required that sewing shelf life of products is more than December.
It is as a result as follows after detecting：
Sensory properties testing result is：It is transparent, clear that acarid, the cleaning solution color of reparation skin are removed obtained by Examples 1 to 5
Clearly, it is visible by naked eyes precipitating.
The testing result of physical and chemical index is：The results are shown in Table 2 for it.
The physical and chemical index result of acarid, the cleaning solution for repairing skin is removed obtained by 2 Examples 1 to 5 of table
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Lead/mg/L | 0.003 | 0.005 | 0.004 | 0.007 | 0.004 |
| Mercury/mg/L | It is not detected | It is not detected | It is not detected | It is not detected | It is not detected |
| Arsenic/mg/L | 0.002 | 0.004 | 0.003 | 0.005 | 0.003 |
Killing microorganism detection result is：Removing acarid, the killing for the cleaning solution for repairing skin obtained by Examples 1 to 5 are micro-
Biological indicators result is respectively as shown in table 3, table 4, table 5, table 6 and table 7.
The killing microbiological indicator result of the cleaning solution of removing acarid, reparation skin obtained by 3 embodiment 1 of table
The killing microbiological indicator result of the cleaning solution of removing acarid, reparation skin obtained by 4 embodiment 2 of table
The killing microbiological indicator result of the cleaning solution of removing acarid, reparation skin obtained by 5 embodiment 3 of table
The killing microbiological indicator result of the cleaning solution of removing acarid, reparation skin obtained by 6 embodiment 4 of table
The killing microbiological indicator result of the cleaning solution of removing acarid, reparation skin obtained by 7 embodiment 5 of table
Security requirement testing result is：The safety of acarid, the cleaning solution for repairing skin is removed obtained by Examples 1 to 5
It is required that testing result is as shown in table 8.
8 security requirement testing result of table
Detection of Stability result is：The shelf-life of acarid, the cleaning solution for repairing skin is removed obtained by Examples 1 to 5 through surveying
Determine more than December.
Conclusion (of pressure testing)：Remove obtained by Examples 1 to 5 acarid, repair the cleaning solution of skin sensory properties, physical and chemical index,
Kill microbiological indicator, 5 aspects of security requirement and stability meet and are higher than national standard.
For the anti-mite effect for verifying the cleaning solution, tested as follows：
Test method：Dust mite is collected from natural environment, and according to the photophobia of acarid, is moved with the of short duration irradiation of fluorescent tube
Dynamic dust mite, and dust mite is separated and collected under an optical microscope with writing brush, every 100~105 dust mites are placed in diameter 50mm, height
In the glassware of 20mm, acarid feed is contained in vessel, 5 groups are arranged altogether.After the completion by cleaning solution obtained by Examples 1 to 5 point
Di Ru not be in 5 glasswares, and sealed with preservative film, be placed under 25 DEG C of isoperibols for 24 hours, after count the inactivation of dust mite
Number simultaneously calculates killing rate.
Wherein, the identification standard for inactivating acarid is：Inactive acarid, which is considered as, in 5min has inactivated.
Total acarid number in killing rate=(total acarid number-survival acarid number in glassware)/glassware.
Experimental result is as shown in table 9.
The acarid killing rate of cleaning solution obtained by 9 Examples 1 to 5 of table
Experimental result：Cleaning solution obtained by Examples 1 to 5 to acarid for 24 hours in single killing rate between 65~70%, i.e.,
If adhering to using the cleaning solution, there is preferable killing effect to acarid.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of cleaning solution removed acarid, repair skin, which is characterized in that the raw material including following parts by weight：Distilled water 65
~75 parts, 15~25 parts of propylene glycol, 1~3 part of glycerol, 1~3 part of Radix Gentianae extract, 0.5~1.5 part of pericarpium zanthoxyli schinifolii extract, rat-tail
0.25~0.75 part and 0.25~0.75 part of lavender plant active peptides of careless plant active peptides.
2. the cleaning solution according to claim 1 removed acarid, repair skin, which is characterized in that further include that parts by weight are
0.1~0.5 part of preservative.
3. the cleaning solution according to claim 2 removed acarid, repair skin, which is characterized in that the preservative is sweet
The mixture of oil and fat acid esters, decoyl hydroximic acid and parahydroxyacet-ophenone.
4. the cleaning solution according to claim 3 removed acarid, repair skin, which is characterized in that the glycerine fatty acid
The weight ratio of ester, decoyl hydroximic acid and parahydroxyacet-ophenone is 1：1~2：1~2.
5. the cleaning solution according to claim 4 removed acarid, repair skin, which is characterized in that including following parts by weight
Raw material：70 parts of distilled water, 20 parts of propylene glycol, 2 parts of glycerol, 2 parts of Radix Gentianae extract, 1 part of pericarpium zanthoxyli schinifolii extract, clary
0.5 part of active peptide, 0.5 part of lavender plant active peptides, 0.05 part of fatty acid glyceride, 0.1 part of decoyl hydroximic acid and to hydroxyl
0.1 part of acetophenone.
6. the cleaning solution according to claim 5 removed acarid, repair skin, which is characterized in that the distilled water is led
Electric rate≤0.1mS/m.
7. the preparation method of the described in any item cleaning solutions removed acarid, repair skin of claim 1~6, which is characterized in that
Include the following steps：
(1) distilled water, propylene glycol and pericarpium zanthoxyli schinifolii extract are mixed and heated heat preservation, obtain mixture a；
(2) mixture a is cooled down, and surplus stock is added and stirs evenly.
8. removing the preparation method of acarid, the cleaning solution for repairing skin according to claim 7, which is characterized in that step (1)
In, the temperature of the heating is 80~90 DEG C, and the time of heat preservation is 25~35min.
9. removing the preparation method of acarid, the cleaning solution for repairing skin according to claim 7, which is characterized in that step (2)
In, it is described to be cooled to 40~50 DEG C.
10. removing the preparation method of acarid, the cleaning solution for repairing skin according to claim 7, which is characterized in that step
(2) in, the revolving speed of the stirring is 15~25r/min, and the time of stirring is 20~30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811187985.8A CN108904399A (en) | 2018-10-12 | 2018-10-12 | It is a kind of to remove acarid, cleaning solution of reparation skin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811187985.8A CN108904399A (en) | 2018-10-12 | 2018-10-12 | It is a kind of to remove acarid, cleaning solution of reparation skin and preparation method thereof |
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| CN108904399A true CN108904399A (en) | 2018-11-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110804499A (en) * | 2019-11-11 | 2020-02-18 | 高艳艳 | Mite-killing laundry detergent and preparation method thereof |
| EP4129316A4 (en) * | 2020-04-24 | 2023-11-01 | Smilebiotek Guangzhou Limited | Application of radix gentianae macrophyllae and monomer compound thereof in killing mites |
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| CN106726658A (en) * | 2017-03-13 | 2017-05-31 | 福州美乐莲生物科技有限公司 | Preservative of a kind of hydroximic acid containing decoyl and parahydroxyacet-ophenone and its preparation method and application and the cosmetics containing the preservative |
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2018
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| CN105802725A (en) * | 2015-12-29 | 2016-07-27 | 中华全国供销合作总社南京野生植物综合利用研究所 | Preparation method and application of novel functional plant powdered oil |
| CN106726658A (en) * | 2017-03-13 | 2017-05-31 | 福州美乐莲生物科技有限公司 | Preservative of a kind of hydroximic acid containing decoyl and parahydroxyacet-ophenone and its preparation method and application and the cosmetics containing the preservative |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110804499A (en) * | 2019-11-11 | 2020-02-18 | 高艳艳 | Mite-killing laundry detergent and preparation method thereof |
| EP4129316A4 (en) * | 2020-04-24 | 2023-11-01 | Smilebiotek Guangzhou Limited | Application of radix gentianae macrophyllae and monomer compound thereof in killing mites |
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