CN109364104A - The Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved - Google Patents
The Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The present invention provides a kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing methods that Rhizoma Et Radix Notopterygii utilization rate can be improved, and are related to the brewed technical field of Chinese medicine, comprising the following steps: are sliced Rhizoma Et Radix Notopterygii, 30-35 DEG C of low temperature drying to moisture content is stand-by lower than 20%；Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 20-30min, cellulase, pectase is added after mixing evenly, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump by sealing, after sealing dipping 2-5h, it drains, is placed in drying in baking oven, takes out and immerse in saline solution, it takes out, the dry 10-15min of microwave irradiation；It will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, it is warming up at 160-180 DEG C and fries, frying time 10-15min, appropriate yellow rice wine is sprayed into using watering can every 1-3min when frying, it takes out rapidly and is put into 5-10 DEG C of refrigerator after frying, 5-10d, the present invention can reinforce notopterygium wind dispelling dehumidifying, inducing meastruation to relieve menalgia effect using the brewed Rhizoma Et Radix Notopterygii of yellow rice wine, improve the curative effect that Rhizoma Et Radix Notopterygii controls rheumatic arthralgia.
Description
Technical field
The present invention relates to the brewed technical fields of Chinese medicine, and in particular to a kind of Rhizoma Et Radix Notopterygii medicine materical crude slice that Rhizoma Et Radix Notopterygii utilization rate can be improved is brewed
Method.
Background technique
Rhizoma Et Radix Notopterygii, Chinese medicine name.Alias Qiang is green, shield Qiang envoy, Hu king envoy, Qiang is sliding, moves back wind envoy, black powder, Umbelliferae, Rhizoma Et Radix Notopterygii
Platymiscium, perennial herb, 60-120 centimetres high, rhizome is sturdy, and elongation is in Bamboo-shaped.Rootstock has withered leaf sheath.Stem is upright,
Cylinder, it is hollow, indulge straight stria, band purple.Its is warm-natured, relieving exterior syndrome and dispelling cold, dispellieg cold and dampness, for affection of exogenous wind-cold, it is headache and adiapneustia,
Cold-dampness numbness, upper limb rheumatalgia pain.It is grown in 2000-4000 meters of height above sea level of border and shrubbery；It is distributed in Chinese Shaanxi, four
River, Gansu, Qinghai, Tibet, Rhizoma Et Radix Notopterygii function expelling cold, eliminating, wind-expelling pain-stopping are used for cold, have headache concurrently, based on bodily pain, often
With medicines such as radix saposhnikoviae, the roots of Dahurain angelica with use.The wet effect of notopterygium wind dispelling is also very significant, the product commonly used for expelling wind and eliminating dampness.
The chemical component of Chinese medicine be it is very complicated, for certain specific Chinese medicine, it is contained therein have it is certain
Physiological action chemical component, during treating disease, it may be possible to rise therapeutic effect effective component, it is also possible to nothing
Imitate even harmful ingredient.Although also not fully aware of for the effective component of most of Chinese medicines at present, people from
The chemical component that physiological action may be played in Chinese medicine is recognized in practice, mainly in alkaloids, glucoside, volatile oil, tree
In several constituents such as rouge, organic acid, grease, inorganic salts.Processing seeks to retain medicative ingredient, and removal is invalid even
It is harmful ingredient.One of the characteristics of Chinese medicine can just be used as medicine after having to pass through processing, this is middle medical drugs.Chinese medicine preparation is root
According to traditional Chinese medical theory, require to be adopted according to the needs and drug self property of diagnosis and treatment based on an overall analysis of the illness and the patient's condition medication, and adjustment, the different of preparation
The pharmaceutical technology taken.Chinese medicine preparation is the summary of Chinese medicine Long-term clinical medication experience.The determination of processing procedure should be with clinical demand
For foundation.Whether processing procedure is reasonable, whether method is appropriate.
Rhizoma Et Radix Notopterygii is brewed first recorded in the Tang Dynasty " celestial being awards treating trauma and fracture secret recipe ", and the Song Dynasty increases cutting, water in which rice has been washed is soaked, roasted, is parched with wine
System.Increasing face is fried again, Herba Epimedii mixes steaming for the Qing Dynasty, sweet stir-fry method.Currently, based on being used so that slice is raw.
Chinese patent CN108310028A discloses a kind of concocting method of Rhizoma Et Radix Notopterygii medicine materical crude slice, is related to Chinese medicine processing technology neck
Domain.Including following raw material: loguat leaf, sargentodoxa cuneata, folium isatidis, radix scutellariae, Rhizoma Et Radix Notopterygii, tea polyphenols, maltose, yellow vinegar.The invention Rhizoma Et Radix Notopterygii
The concocting method of medicine materical crude slice is easy, and Rhizoma Et Radix Notopterygii medicine materical crude slice forming is not easy to go mouldy, which reduces the stream of Rhizoma Et Radix Notopterygii effective component
It loses, to improve the utilization rate of Rhizoma Et Radix Notopterygii, the Rhizoma Et Radix Notopterygii medicine materical crude slice of preparation is in good taste, have and dissipates exterior cold, wind-damp dispelling, sharp joint, analgesic
Effect.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing methods that Rhizoma Et Radix Notopterygii utilization rate can be improved.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
30-35 DEG C of low temperature drying is stand-by lower than 20% to moisture content；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 20-30min, cellulase, pectase stirring is added
After even, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 2-5h, takes out the drip of Rhizoma Et Radix Notopterygii piece by sealing
It is dry, it is placed in 50-55 DEG C of dry 3-6h in baking oven, takes out and immerses in saline solution, is taken out after impregnating 1-3min, microwave irradiation is dry
10-15min；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 160-180 DEG C and fry, the frying time
10-15min sprays into appropriate yellow rice wine using watering can every 1-3min when frying, takes out rapidly after frying and is put into 5-10 DEG C
In refrigerator, 5-10d.
Further, in step (1) every with a thickness of 0.1-0.3cm.
Further, step (2) cellulase, pectase weight ratio be 1-5:1-5.
Further, step (2) cellulase, pectase total weight be Rhizoma Et Radix Notopterygii sheet weight 1-3%.
Further, the mass concentration of saline solution is 20-35% in step (2).
Further, the frequency of microwave irradiation is 915MHz in step (2).
Further, machine for stir-frying Chinese medicine heating rate is 15-25 DEG C/min in step (3).
(3) beneficial effect
The present invention provides a kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing methods that Rhizoma Et Radix Notopterygii utilization rate can be improved, and have the advantages that
Yellow rice wine contain functional oligose abundant, these oligosaccharide be in brewing process, effect of the material through microbial enzyme and
It generates, after functional oligose enters human body, is not absorbed by the body, does not generate heat, but can promote in enteron aisle beneficial to micro- life
The growth and development of object Bifidobacterium can improve function of intestinal canal, strengthen immunity, promote absorption of the human body to Rhizoma Et Radix Notopterygii pharmacological property, improve
Rhizoma Et Radix Notopterygii utilization rate, and the kind current blood vessels of yellow rice wine can reinforce notopterygium wind dispelling dehumidifying, inducing meastruation to relieve menalgia using yellow rice wine brewed Rhizoma Et Radix Notopterygii
Effect improves the curative effect that Rhizoma Et Radix Notopterygii controls rheumatic arthralgia, and cellulase, pectinase treatment can destroy Rhizoma Et Radix Notopterygii cell wall, is conducive to Rhizoma Et Radix Notopterygii
Absorption to yellow rice wine, subsequent salt water retting can play the role of similar salt and process, can rise and propose the efficacy of a drug, enhance dispelling wind and eliminating dampness
Effect, microwave irradiation can rapid evaporation water, prevent beneficiating ingredient to be lost.
Specific embodiment
Embodiment 1:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 32 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 25min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 5:2, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
1.5%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 3h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in
52 DEG C of dry 5h in baking oven take out and immerse in the saline solution that mass concentration is 25%, take out after impregnating 2min, and microwave irradiation is dry
14min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 165 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 20 DEG C/min, frying time 12min, sprays into appropriate yellow rice wine using watering can every 1min when frying, after frying rapidly
Taking-up is put into 8 DEG C of refrigerator, 6d.
Embodiment 2:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 30 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 28min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 1:3, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
2%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 3h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
52 DEG C of dry 3h in case take out and immerse in the saline solution that mass concentration is 30%, take out after impregnating 3min, and microwave irradiation is dry
14min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 170 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 20 DEG C/min, frying time 14min, sprays into appropriate yellow rice wine using watering can every 1min when frying, after frying rapidly
Taking-up is put into 6 DEG C of refrigerator, 7d.
Embodiment 3:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 35 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 28min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 3:2, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
2%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 5h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
52 DEG C of dry 6h in case take out and immerse in the saline solution that mass concentration is 24%, take out after impregnating 3min, and microwave irradiation is dry
14min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 168 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 18 DEG C/min, frying time 12min, sprays into appropriate yellow rice wine using watering can every 3min when frying, after frying rapidly
Taking-up is put into 6 DEG C of refrigerator, 10d.
Embodiment 4:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 33 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 30min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 4:3, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
1%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 5h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
54 DEG C of dry 6h in case take out and immerse in the saline solution that mass concentration is 35%, take out after impregnating 2min, and microwave irradiation is dry
12min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 172 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 15 DEG C/min, frying time 15min, sprays into appropriate yellow rice wine using watering can every 2min when frying, after frying rapidly
Taking-up is put into 5 DEG C of refrigerator, 10d.
Embodiment 5:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 30 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 20min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 1:1, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
1%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 2h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
50 DEG C of dry 3h in case take out and immerse in the saline solution that mass concentration is 20%, take out after impregnating 1min, and microwave irradiation is dry
10min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 160 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 15 DEG C/min, frying time 10min, sprays into appropriate yellow rice wine using watering can every 1min when frying, after frying rapidly
Taking-up is put into 5 DEG C of refrigerator, 5d.
Embodiment 6:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 35 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 30min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 5:3, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
3%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 5h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
55 DEG C of dry 6h in case take out and immerse in the saline solution that mass concentration is 35%, take out after impregnating 3min, and microwave irradiation is dry
15min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 180 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 25 DEG C/min, frying time 15min, sprays into appropriate yellow rice wine using watering can every 3min when frying, after frying rapidly
Taking-up is put into 10 DEG C of refrigerator, 10d.
Embodiment 7:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 30 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 30min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 1:5, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
1%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 5h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
50 DEG C of dry 6h in case take out and immerse in the saline solution that mass concentration is 20%, take out after impregnating 3min, and microwave irradiation is dry
10min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 180 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 15 DEG C/min, frying time 15min, sprays into appropriate yellow rice wine using watering can every 1min when frying, after frying rapidly
Taking-up is put into 10 DEG C of refrigerator, 5d.
Embodiment 8:
A kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, comprising the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
Every with a thickness of 0.1-0.3cm, 35 DEG C of low temperature dryings to moisture content are stand-by lower than 20%；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 20min, cellulase is added, pectase stirs evenly
Afterwards, seal, cellulase, pectase weight ratio be 5:1, and the total weight of cellulase, pectase is Rhizoma Et Radix Notopterygii sheet weight
3%, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 2h, Rhizoma Et Radix Notopterygii piece is taken out and drains, be placed in baking
55 DEG C of dry 3h in case take out and immerse in the saline solution that mass concentration is 35%, take out after impregnating 1min, and microwave irradiation is dry
15min, the frequency of microwave irradiation are 915MHz；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 160 DEG C and fry, machine for stir-frying Chinese medicine heating speed
Degree is 25 DEG C/min, frying time 15min, sprays into appropriate yellow rice wine using watering can every 1min when frying, after frying rapidly
Taking-up is put into 10 DEG C of refrigerator, 5d.
The Rhizoma Et Radix Notopterygii medicine materical crude slice and commercially available common Rhizoma Et Radix Notopterygii medicine materical crude slice for taking above-described embodiment 1-8 to prepare, according to " People's Republic of China's medicine
Allusion quotation " a Rhizoma Et Radix Notopterygii quality standard and four 0100 ruless of preparations carry out full item inspections.
Test:
(1) the Rhizoma Et Radix Notopterygii medicine materical crude slice of Example 1-8 preparation is ground into powder 1g, and respectively plus methanol 5ml, ultrasonic treatment 20 minutes are quiet
It sets, takes supernatant as test solution.Nodakenin reference substance separately is taken, adds methanol that solution of every 1ml containing 0.5mg is made,
As reference substance solution.It is tested according to thin-layered chromatography (VI B of annex), draws each 2-4 μ l of above two solution, put respectively in same
On silica gel g thin-layer plate with the preparation of 3% sodium acetate solution, with chloroform/methanol (8:2) for solvent, it is unfolded, takes out, dry in the air
It is dry, it sets and is inspected under ultraviolet lamp (365nm), in sample chromatogram, at the position corresponding to the chromatogram of the reference substance, show identical indigo plant
Color fluorescence spot, effective component are identical.
(2) limit test of microbe is carried out after eliminating test sample bacteriostatic activity using membrane-filter procedure.Aerobic bacteria is total, mould
Bacterium and saccharomycete sum are according to four " non-sterile product limit test of microbe: microorganism meter of the Pharmacopoeia of the People's Republic of China
Number method (general rule 1105) " checks；Detection of Salmonella, bile tolerance gram-negative bacteria etc. control bacterium according to the Pharmacopoeia of the People's Republic of China four
Portion's " non-sterile product limit test of microbe: Control bacteria examination method (general rule 1106) " checks that inspection result is according to " the Chinese people
Republic's pharmacopeia " four " non-sterile product limitation standard in microbe (general rule 1107) is determined.As the result is shown according to the present invention
Embodiment 1-8 preparation Rhizoma Et Radix Notopterygii medicine materical crude slice whole indexs it is qualified, and the mould of commercially available common Rhizoma Et Radix Notopterygii medicine materical crude slice, saccharomycete sum and
Aerobic bacteria sum is unqualified；
(3) the Rhizoma Et Radix Notopterygii medicine materical crude slice and commercially available common Rhizoma Et Radix Notopterygii medicine materical crude slice of 1-8 of embodiment of the present invention preparation, in 40 ± 2 DEG C of temperature, relative humidity
It places 6 months under the conditions of 75 ± 5%, in 0,1,2,3,6 the end of month inspection by sampling appearance, moisture and active constituent content, adds
Fast stability test is the result shows that commercially available common Rhizoma Et Radix Notopterygii medicine materical crude slice has generated mildew phenomena the 2nd the end of month, and effective component contains
Amount gradually decreases during study on the stability, until the content of effective component drops to 20% when 6 months study on the stability are completed,
And 1-8 of the embodiment of the present invention preparation Rhizoma Et Radix Notopterygii medicine materical crude slice without mildew, the content of effective component is dropped by less than 5%.
To sum up, Rhizoma Et Radix Notopterygii medicine materical crude slice items quality prepared by the present invention is qualified, and can place for a long time, and property is stablized.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method that Rhizoma Et Radix Notopterygii utilization rate can be improved, which comprises the following steps:
(1) fibrous root and silt are removed after harvesting Rhizoma Et Radix Notopterygii, is dried, and surface impurity is removed, clear water is protected from light after cleaning to be dried, it is sliced,
30-35 DEG C of low temperature drying is stand-by lower than 20% to moisture content；
(2) Rhizoma Et Radix Notopterygii piece is added in yellow rice wine, after ultrasonic vibration handles 20-30min, cellulase, pectase stirring is added
After even, sealing system is evacuated to 0.8-1.2 atmospheric pressure using vacuum pump, after sealing impregnates 2-5h, takes out the drip of Rhizoma Et Radix Notopterygii piece by sealing
It is dry, it is placed in 50-55 DEG C of dry 3-6h in baking oven, takes out and immerses in saline solution, is taken out after impregnating 1-3min, microwave irradiation is dry
10-15min；
(3) it will be added in machine for stir-frying Chinese medicine by above-mentioned processed Rhizoma Et Radix Notopterygii piece, and be warming up at 160-180 DEG C and fry, the frying time
10-15min sprays into appropriate yellow rice wine using watering can every 1-3min when frying, takes out rapidly after frying and is put into 5-10 DEG C
In refrigerator, 5-10d.
2. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (1)
In every with a thickness of 0.1-0.3cm.
3. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (2)
Cellulase, pectase weight ratio be 1-5:1-5.
4. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (2)
Cellulase, pectase total weight be Rhizoma Et Radix Notopterygii sheet weight 1-3%.
5. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (2)
The mass concentration of middle saline solution is 20-35%.
6. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (2)
The frequency of middle microwave irradiation is 915MHz.
7. the Rhizoma Et Radix Notopterygii medicine materical crude slice brewing method of Rhizoma Et Radix Notopterygii utilization rate can be improved as described in claim 1, which is characterized in that step (3)
Middle machine for stir-frying Chinese medicine heating rate is 15-25 DEG C/min.
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| CN112336759A (en) * | 2020-08-18 | 2021-02-09 | 河西学院 | Processing method of notopterygium root decoction pieces |
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Application publication date: 20190222 |