CN109310698B - 用于治疗耳部病症的(+)-阿扎司琼 - Google Patents

用于治疗耳部病症的(+)-阿扎司琼 Download PDF

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Publication number
CN109310698B
CN109310698B CN201780036585.4A CN201780036585A CN109310698B CN 109310698 B CN109310698 B CN 109310698B CN 201780036585 A CN201780036585 A CN 201780036585A CN 109310698 B CN109310698 B CN 109310698B
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China
Prior art keywords
azasetron
hearing loss
composition
pharmaceutically acceptable
compound
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CN201780036585.4A
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Chinese (zh)
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CN109310698A (zh
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乔纳斯·戴赫弗耶德-约翰逊
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Sensorion SA
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Sensorion SA
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Priority claimed from PCT/EP2017/059058 external-priority patent/WO2017178645A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780036585.4A 2016-04-14 2017-04-14 用于治疗耳部病症的(+)-阿扎司琼 Active CN109310698B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662322690P 2016-04-14 2016-04-14
US62/322,690 2016-04-14
EP16180192.3 2016-07-19
EP16180192 2016-07-19
PCT/EP2017/059058 WO2017178645A1 (en) 2016-04-14 2017-04-14 (+)-azasetron for use in the treatment of ear disorders

Publications (2)

Publication Number Publication Date
CN109310698A CN109310698A (zh) 2019-02-05
CN109310698B true CN109310698B (zh) 2021-12-24

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ID=65588799

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CN201780036585.4A Active CN109310698B (zh) 2016-04-14 2017-04-14 用于治疗耳部病症的(+)-阿扎司琼

Country Status (18)

Country Link
US (2) US11612605B2 (https=)
EP (1) EP4335508A3 (https=)
JP (1) JP7158723B2 (https=)
CN (1) CN109310698B (https=)
AU (1) AU2023202897B2 (https=)
CL (1) CL2018002930A1 (https=)
DK (1) DK3442537T3 (https=)
ES (1) ES2975016T3 (https=)
FI (1) FI3442537T3 (https=)
HR (1) HRP20240453T1 (https=)
HU (1) HUE066000T2 (https=)
IL (1) IL262305B (https=)
MX (1) MX384045B (https=)
NZ (1) NZ747201A (https=)
PL (1) PL3442537T3 (https=)
RS (1) RS65379B1 (https=)
SI (1) SI3442537T1 (https=)
ZA (1) ZA201806894B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2882602T3 (es) * 2015-05-18 2021-12-02 Sensorion Azasetrón para usar en el tratamiento de la pérdida auditiva

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002067987A2 (en) * 2001-02-23 2002-09-06 Glaxo Group Limited Combinations of a 5ht1 receptor agonist with an analgesic, and an anti-emetic and/or a gastroprokinetic agent
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
EP2253316A1 (en) * 2009-05-20 2010-11-24 INSERM (Institut National de la Santé et de la Recherche Medicale) serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of vestibular deficits
CN102458400A (zh) * 2009-05-20 2012-05-16 国立健康与医学研究所 用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
WO2016184900A1 (en) * 2015-05-18 2016-11-24 Sensorion Calcineurin inhibitors of the setron family for the treatment of hearing loss

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US4695578A (en) 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
US5360800A (en) 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
CA1304082C (en) 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB0009914D0 (en) 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
US20030044356A1 (en) 2001-04-20 2003-03-06 Jin Auh Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
GB0213869D0 (en) 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
NZ541009A (en) 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US20040204466A1 (en) 2003-04-14 2004-10-14 Orchid Chemicals And Pharmaceuticals Ltd. Treatment of bronchial asthma using 5-HT3 receptor antagonists
US20070265329A1 (en) 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
EP2725035A1 (en) 2007-10-02 2014-04-30 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract
US20100016218A1 (en) 2008-07-14 2010-01-21 Otonomy, Inc. Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders
CN101786963B (zh) 2010-03-03 2013-05-08 山东众诚药业股份有限公司 阿扎司琼中间体的合成方法
JP2015511242A (ja) 2012-02-23 2015-04-16 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラリシェルシェ メディカル） 病変性前庭障害の治療に使用するカルシニューリン阻害剤
EP2872128B1 (en) 2012-07-16 2020-02-19 Cornell University Nicotinamide riboside to treat hearing loss
BR112016002205A2 (pt) * 2013-07-31 2017-08-01 Bluepharma Ind Farmaceutica S A filmes orodispersíveis
CN104557906A (zh) 2015-01-21 2015-04-29 扬子江药业集团四川海蓉药业有限公司 一种盐酸阿扎司琼的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002067987A2 (en) * 2001-02-23 2002-09-06 Glaxo Group Limited Combinations of a 5ht1 receptor agonist with an analgesic, and an anti-emetic and/or a gastroprokinetic agent
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
EP2253316A1 (en) * 2009-05-20 2010-11-24 INSERM (Institut National de la Santé et de la Recherche Medicale) serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of vestibular deficits
CN102458400A (zh) * 2009-05-20 2012-05-16 国立健康与医学研究所 用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
WO2016184900A1 (en) * 2015-05-18 2016-11-24 Sensorion Calcineurin inhibitors of the setron family for the treatment of hearing loss

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
putting chirality to work: the strategy of chiral switches;Israel Agranat et al.;《nature reviews drug discovery》;20021031;第1卷(第10期);第753-768页 *

Also Published As

Publication number Publication date
DK3442537T3 (da) 2024-03-25
EP4335508A3 (en) 2024-07-10
US20230226071A1 (en) 2023-07-20
NZ747201A (en) 2023-02-24
JP7158723B2 (ja) 2022-10-24
US20190083503A1 (en) 2019-03-21
JP2019513780A (ja) 2019-05-30
EP4335508A2 (en) 2024-03-13
FI3442537T3 (fi) 2024-04-04
IL262305B (en) 2022-03-01
HUE066000T2 (hu) 2024-06-28
US11612605B2 (en) 2023-03-28
IL262305A (en) 2018-11-29
HRP20240453T1 (hr) 2024-06-21
MX2018012587A (es) 2019-03-07
AU2023202897B2 (en) 2025-01-30
CL2018002930A1 (es) 2019-02-15
ES2975016T3 (es) 2024-07-02
SI3442537T1 (sl) 2024-05-31
MX384045B (es) 2025-03-14
PL3442537T3 (pl) 2024-07-15
ZA201806894B (en) 2023-03-29
RS65379B1 (sr) 2024-04-30
AU2023202897A1 (en) 2023-05-25
CN109310698A (zh) 2019-02-05

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