AU2023202897B2 - (+)-Azasetron for use in the treatment of ear disorders - Google Patents

(+)-Azasetron for use in the treatment of ear disorders Download PDF

Info

Publication number
AU2023202897B2
AU2023202897B2 AU2023202897A AU2023202897A AU2023202897B2 AU 2023202897 B2 AU2023202897 B2 AU 2023202897B2 AU 2023202897 A AU2023202897 A AU 2023202897A AU 2023202897 A AU2023202897 A AU 2023202897A AU 2023202897 B2 AU2023202897 B2 AU 2023202897B2
Authority
AU
Australia
Prior art keywords
azasetron
hearing loss
composition
pharmaceutically acceptable
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2023202897A
Other languages
English (en)
Other versions
AU2023202897A1 (en
Inventor
Jonas DYHRFJELD-JOHNSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sensorion SA
Original Assignee
Sensorion SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2017/059058 external-priority patent/WO2017178645A1/en
Application filed by Sensorion SA filed Critical Sensorion SA
Priority to AU2023202897A priority Critical patent/AU2023202897B2/en
Publication of AU2023202897A1 publication Critical patent/AU2023202897A1/en
Application granted granted Critical
Publication of AU2023202897B2 publication Critical patent/AU2023202897B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2023202897A 2016-04-14 2023-05-09 (+)-Azasetron for use in the treatment of ear disorders Active AU2023202897B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023202897A AU2023202897B2 (en) 2016-04-14 2023-05-09 (+)-Azasetron for use in the treatment of ear disorders

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662322690P 2016-04-14 2016-04-14
US62/322,690 2016-04-14
EP16180192.3 2016-07-19
EP16180192 2016-07-19
PCT/EP2017/059058 WO2017178645A1 (en) 2016-04-14 2017-04-14 (+)-azasetron for use in the treatment of ear disorders
AU2017248618A AU2017248618B2 (en) 2016-04-14 2017-04-14 (+)-azasetron for use in the treatment of ear disorders
AU2023202897A AU2023202897B2 (en) 2016-04-14 2023-05-09 (+)-Azasetron for use in the treatment of ear disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2017248618A Division AU2017248618B2 (en) 2016-04-14 2017-04-14 (+)-azasetron for use in the treatment of ear disorders

Publications (2)

Publication Number Publication Date
AU2023202897A1 AU2023202897A1 (en) 2023-05-25
AU2023202897B2 true AU2023202897B2 (en) 2025-01-30

Family

ID=65588799

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2023202897A Active AU2023202897B2 (en) 2016-04-14 2023-05-09 (+)-Azasetron for use in the treatment of ear disorders

Country Status (18)

Country Link
US (2) US11612605B2 (https=)
EP (1) EP4335508A3 (https=)
JP (1) JP7158723B2 (https=)
CN (1) CN109310698B (https=)
AU (1) AU2023202897B2 (https=)
CL (1) CL2018002930A1 (https=)
DK (1) DK3442537T3 (https=)
ES (1) ES2975016T3 (https=)
FI (1) FI3442537T3 (https=)
HR (1) HRP20240453T1 (https=)
HU (1) HUE066000T2 (https=)
IL (1) IL262305B (https=)
MX (1) MX384045B (https=)
NZ (1) NZ747201A (https=)
PL (1) PL3442537T3 (https=)
RS (1) RS65379B1 (https=)
SI (1) SI3442537T1 (https=)
ZA (1) ZA201806894B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2882602T3 (es) * 2015-05-18 2021-12-02 Sensorion Azasetrón para usar en el tratamiento de la pérdida auditiva

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133663A1 (en) * 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
WO2016184900A1 (en) * 2015-05-18 2016-11-24 Sensorion Calcineurin inhibitors of the setron family for the treatment of hearing loss

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
US5360800A (en) 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
CA1304082C (en) 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB0009914D0 (en) 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
GB0104554D0 (en) 2001-02-23 2001-04-11 Glaxo Group Ltd New uses
US20030044356A1 (en) 2001-04-20 2003-03-06 Jin Auh Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
GB0213869D0 (en) 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
NZ541009A (en) 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US20040204466A1 (en) 2003-04-14 2004-10-14 Orchid Chemicals And Pharmaceuticals Ltd. Treatment of bronchial asthma using 5-HT3 receptor antagonists
US20070265329A1 (en) 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
EP2725035A1 (en) 2007-10-02 2014-04-30 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract
US20100016218A1 (en) 2008-07-14 2010-01-21 Otonomy, Inc. Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders
EP2253316B1 (en) * 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN101786963B (zh) 2010-03-03 2013-05-08 山东众诚药业股份有限公司 阿扎司琼中间体的合成方法
JP2015511242A (ja) 2012-02-23 2015-04-16 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラリシェルシェ メディカル） 病変性前庭障害の治療に使用するカルシニューリン阻害剤
EP2872128B1 (en) 2012-07-16 2020-02-19 Cornell University Nicotinamide riboside to treat hearing loss
BR112016002205A2 (pt) * 2013-07-31 2017-08-01 Bluepharma Ind Farmaceutica S A filmes orodispersíveis
CN104557906A (zh) 2015-01-21 2015-04-29 扬子江药业集团四川海蓉药业有限公司 一种盐酸阿扎司琼的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010133663A1 (en) * 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
WO2016184900A1 (en) * 2015-05-18 2016-11-24 Sensorion Calcineurin inhibitors of the setron family for the treatment of hearing loss

Also Published As

Publication number Publication date
DK3442537T3 (da) 2024-03-25
EP4335508A3 (en) 2024-07-10
US20230226071A1 (en) 2023-07-20
NZ747201A (en) 2023-02-24
JP7158723B2 (ja) 2022-10-24
US20190083503A1 (en) 2019-03-21
JP2019513780A (ja) 2019-05-30
EP4335508A2 (en) 2024-03-13
FI3442537T3 (fi) 2024-04-04
IL262305B (en) 2022-03-01
HUE066000T2 (hu) 2024-06-28
US11612605B2 (en) 2023-03-28
IL262305A (en) 2018-11-29
HRP20240453T1 (hr) 2024-06-21
MX2018012587A (es) 2019-03-07
CL2018002930A1 (es) 2019-02-15
ES2975016T3 (es) 2024-07-02
SI3442537T1 (sl) 2024-05-31
CN109310698B (zh) 2021-12-24
MX384045B (es) 2025-03-14
PL3442537T3 (pl) 2024-07-15
ZA201806894B (en) 2023-03-29
RS65379B1 (sr) 2024-04-30
AU2023202897A1 (en) 2023-05-25
CN109310698A (zh) 2019-02-05

Similar Documents

Publication Publication Date Title
EP2203050B1 (en) Topical use of r(+)-n-propargyl-1-aminoindan to treat or prevent hearing loss
AU2017248618B2 (en) (+)-azasetron for use in the treatment of ear disorders
AU2023202897B2 (en) (+)-Azasetron for use in the treatment of ear disorders
HK40106593A (en) (+)-azasetron for use in the treatment of ear disorders
JP6271804B1 (ja) 耳炎の治療のための組成物および方法
HK40003071A (en) (+)-azasetron for use in the treatment of ear disorders
HK40003071B (en) (+)-azasetron for use in the treatment of ear disorders
US20230390273A1 (en) 4-phenyl-tetrahydropyridine derivatives for treating hearing diseases
CN110664765B (zh) 一种倍他司汀舌下含片及其制备方法和用途
BR112018071123B1 (pt) (+)-azasetron para uso no tratamento de distúrbios de ouvido
US20220265668A1 (en) Treatment and/or prevention of lesions in the central auditory nervous system
EP4501346A1 (en) Method for the prevention of hearing loss induced by a platinum-based chemotherapy drug
WO2026062170A1 (en) Azasetron for the prevention of hearing loss in subjects receiving cisplatin
AU2024290039A1 (en) Azasetron for the preservation of residual hearing following cochlear implantation
RU2452476C2 (ru) Производные 1-аминоалкилциклогексана для лечения и предупреждения потери слуха
US10350232B1 (en) Medicinal drops
Pawlowski Peter S. Roland, MD

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)