CN109303879B - 一种治疗湿疹的中药贴膏剂及其制备方法 - Google Patents
一种治疗湿疹的中药贴膏剂及其制备方法 Download PDFInfo
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- CN109303879B CN109303879B CN201811385039.4A CN201811385039A CN109303879B CN 109303879 B CN109303879 B CN 109303879B CN 201811385039 A CN201811385039 A CN 201811385039A CN 109303879 B CN109303879 B CN 109303879B
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- sodium alginate
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Abstract
本发明涉及医疗用品领域,尤其涉及一种治疗湿疹的中药贴膏剂及其制备方法。包括膏药层和透气抗菌基层,膏药层由以下重量份数的原料制成:黄连6‑9份,丹皮3‑7份,徐长卿3‑6份,苍耳子7‑18份,蝉衣5‑15份,白鲜皮5‑15份,苦参8‑17份,防风3‑16份,枳壳5‑10份,桔梗8‑20份,土茯苓5‑15份,荆芥5‑13份和连翘5‑15份,透气抗菌基层为聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠‑聚乙烯醇凝胶膜,本发明在多孔海藻酸钠‑聚乙烯醇凝胶膜表面上成功接枝聚羟乙基丙烯酰胺,具有优异的透气性和抗菌性。
Description
技术领域
本发明涉及医疗用品领域,尤其涉及一种治疗湿疹的中药贴膏剂及其制备方法。
背景技术
湿疹是由多种内外因素引起的瘙痒剧烈的一种皮肤炎症反应,其发病机制复杂,一般认为与变态反应有一定关系。作为一种常见的炎症性皮肤病,湿疹损害处常有渗出潮湿倾向,多形性皮疹,以红斑、丘疹、水疱,渗出、糜烂为特征,由于湿疹瘙痒较重,患者很容易将湿疹抓破,引起细菌的感染,因此,通过贴膏剂对湿疹进行治疗时,如何增加透气性并且同时能够预防细菌对于湿疹部位的侵染,也显得尤其重要。
例如,一种在中国专利文献上公开的“一种治疗湿疹皮炎的外用药物组合物及其制备方法”,其公告号CN101926858A,其公开了一种治疗湿疹皮炎的外用药物组合物,它是由下述重量配比的原料药制备而成的外用药剂:黄芩27-81份、棘豆27-81份、大黄19-57份、诃子27-81份。该发明药物对湿疹和皮炎,包括接触性皮炎、过敏性皮炎、自敏性皮炎、传染性湿疹样皮炎等均具有很好的疗效。但该发明的膏剂由于不具备抗菌效果,在外用时,会引起细菌的感染,加重患者的病情。
发明内容
本发明是为了克服目前上述问题,提出了一种透气,且具有抗菌功能的用于治疗湿疹的中药贴膏剂。
为了实现上述目的,本发明采用以下技术方案:
一种治疗湿疹的中药贴膏剂,其特征在于,贴膏剂包括膏药层和透气抗菌基层,所述膏药层由以下重量份数的原料制成:黄连6-9份,丹皮3-7份,徐长卿3-6份,苍耳子7-18份,蝉衣5-15份,白鲜皮5-15份,苦参8-17份,防风3-16份,枳壳5-10份,桔梗8-20份,土茯苓5-15份,荆芥5-13份和连翘5-15份,所述透气抗菌基层为聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜。
本发明的中药贴膏剂包括两层结构,其中膏药层由十三味中药熬制而成,能够消炎止痒,用于治疗湿疹,贴膏剂透气抗菌基层为采用海藻酸钠和聚乙烯醇制备得到的凝胶构成,并且赋予其更为强大的透气性和抗菌性能,使得贴膏剂在使用时,不但舒适透气,并且能够防止细菌侵染病患处,大大提高了贴膏剂的实用性,并且,海藻酸钠和聚乙烯醇制备得到的凝胶绿色环保,在贴膏剂使用完之后,能够自然降解从而不污染环境。
作为优选,所述贴膏剂的制备步骤如下:
(1)将海藻酸钠与聚乙烯醇溶于去离子水中,放置5-7h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入交联剂溶液,固化12-24h后干燥,得到海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入盐酸水溶液中浸渍3-6h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将羟乙基丙烯酰胺接枝于多孔海藻酸钠-聚乙烯醇凝胶膜的表面和孔壁上,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜,用于作为贴膏剂的透气抗菌基层;
(6)将制备膏药层的原料碾碎成细粉,混合后加入5-10倍重量的60-70%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.2-1.3的稠膏,然后将稠膏涂于步骤(5)所得聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
本发明贴膏剂采用海藻酸钠-聚乙烯醇凝胶膜作为基层,为了增加贴膏剂的透气性,发明人在制备海藻酸钠-聚乙烯醇凝胶膜时混入了CaCO3颗粒,随后,将混入CaCO3颗粒的海藻酸钠-聚乙烯醇凝胶膜放置于盐酸水溶液中,此时海藻酸钠-聚乙烯醇凝胶膜中的CaCO3颗粒会溶于盐酸水溶液中,得到了多孔海藻酸钠-聚乙烯醇凝胶膜,多孔海藻酸钠-聚乙烯醇凝胶膜上的孔洞相互连通,赋予多孔海藻酸钠-聚乙烯醇凝胶膜更好的透气性,随后,为了赋予其抗菌性能,利用了多孔海藻酸钠-聚乙烯醇凝胶膜表面富含的羟基,将多孔海藻酸钠-聚乙烯醇凝胶膜进行了羟乙基丙烯酰胺接枝,由于多孔海藻酸钠-聚乙烯醇凝胶膜上具有大量的孔洞,因此,羟乙基丙烯酰胺不仅能接枝在多孔海藻酸钠-聚乙烯醇凝胶膜的表面,也能接枝在多孔海藻酸钠-聚乙烯醇凝胶膜内部的孔洞内,使得接枝表面积大大增加,从而使得其抗菌性能大大增加,随后,将膏药层的原料制成浓稠的稠膏,随后将其涂覆于羟乙基丙烯酰胺接枝的多孔海藻酸钠-聚乙烯醇凝胶膜表面,切段,盖衬后,即得贴膏剂成品。
作为优选,步骤(1)中所述海藻酸钠与聚乙烯醇的质量比为1-5:1。
作为优选,步骤(2)中所述CaCO3粒径为800-2500目。
CaCO3粒径用来调控多孔海藻酸钠-聚乙烯醇凝胶膜的孔径,从而使得多孔海藻酸钠-聚乙烯醇凝胶膜具有较高的透气性和较高的抗菌性,800-2500目粒径的CaCO3使得多孔海藻酸钠-聚乙烯醇凝胶膜具有较高透气性和较高抗菌性的同时,不影响多孔海藻酸钠-聚乙烯醇凝胶膜其本身的强度。
作为优选,步骤(3)中所述交联剂为含有2-4wt%CaCl2的饱和硼酸溶液。
海藻酸钠的交联剂为CaCl2,聚乙烯醇的交联剂为硼酸,因此使用含有2-4wt%CaCl2的饱和硼酸溶液时,海藻酸钠与聚乙烯醇混合物更易凝胶。
作为优选,步骤(5)中所述羟乙基丙烯酰胺的接枝包括以下步骤:
(a)将多孔海藻酸钠-聚乙烯醇凝胶膜放于3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在20-25℃下静置8-12h,随后依次使用乙醇和去离子水吹干;
(b)将吹干后的多孔海藻酸钠-聚乙烯醇凝胶膜置于羟乙基丙烯酰、三-(N,N-二甲氨基乙基)胺和甲醇混合液中溶液中,随后加入溴化亚铜,在氮气保护下,常温下反应10-18h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜。
由于多孔海藻酸钠-聚乙烯醇凝胶膜表面具有大量的羟基,因此,将多孔海藻酸钠-聚乙烯醇凝胶膜放于3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷与多孔海藻酸钠-聚乙烯醇凝胶膜表面的羟基发生脱水反应,从而在多孔海藻酸钠-聚乙烯醇凝胶膜表面成功得接枝所需引发剂,随后,将多孔海藻酸钠-聚乙烯醇凝胶膜置于单体羟乙基丙烯酰和配体三-(N,N-二甲氨基乙基)胺溶液中,加入溴化亚铜,在氮气保护下,反应一段时间之后,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜,由于聚羟乙基丙烯酰胺具有优异的生物分子黏附性能,因此聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜具有优异的抗菌性能,方便实际使用。
作为优选,步骤(b)中所述羟乙基丙烯酰和三-(N,N-二甲氨基乙基)胺的摩尔比为30-35:1。
作为优选,步骤(b)中所述羟乙基丙烯酰和溴化亚铜的摩尔比为60-70:1。
作为优选,所述透气抗菌基层的厚度为3-5mm。
因此,本发明具有如下有益效果:本发明使用多孔海藻酸钠-聚乙烯醇凝胶膜作为贴膏剂的基层,具有优异的透气性,并且,在多孔海藻酸钠-聚乙烯醇凝胶膜表面上成功接枝聚羟乙基丙烯酰胺,赋予其优异的抗菌性能,且由于多孔海藻酸钠-聚乙烯醇凝胶膜内部具有大量孔洞,使得聚羟乙基丙烯酰胺具有更多的接枝面积,使得其抗菌性能更为优异。
具体实施方式
以下结合具体实施例对本发明方案进行更加清楚、完整地描述,显然所描述实施例仅为本发明一部分实施例,而不是全部实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明的保护范围。
实施例1:贴膏剂的制备包括以下步骤:
(1)将20g海藻酸钠与20g聚乙烯醇溶于100g去离子水中,放置5h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入5g的1400目CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入0.9g的含有2wt%CaCl2的饱和硼酸溶液,固化12h后干燥,得到厚度为3mm的海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入0.09mol/L盐酸水溶液中浸渍5h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将多孔海藻酸钠-聚乙烯醇凝胶膜浸没于1wt%3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在25℃下静置8h,随后依次使用乙醇和去离子水吹干;
(6)将吹干后的50g多孔海藻酸钠-聚乙烯醇凝胶膜浸没于50mmol羟乙基丙烯酰、1.6mmol三-(N,N-二甲氨基乙基)胺、50ml甲醇和50ml去离子水的混合溶液中,随后加入0.83mmol溴化亚铜,在氮气保护下,常温下反应14h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜;
(7)取重量份数为黄连9份,丹皮3份,徐长卿5份,苍耳子12份,蝉衣5份,白鲜皮15份,苦参17份,防风10份,枳壳5份,桔梗14份,土茯苓15份,荆芥5份和连翘15份十三味中药作为制备膏药层的原料,将上述十三味中药碾碎成细粉,混合后加入5倍重量的60%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.25的稠膏,然后将稠膏涂于步骤(6)所得聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
实施例2:贴膏剂的制备包括以下步骤:
(1)将50g海藻酸钠与20g聚乙烯醇溶于120g去离子水中,放置6h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入7g的2000目CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入0.8g含有3wt%CaCl2的饱和硼酸溶液,固化14h后干燥,得到厚度为5mm的海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入0.1mol/L盐酸水溶液中浸渍4h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将多孔海藻酸钠-聚乙烯醇凝胶膜浸没于1.5wt%3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在22℃下静置9h,随后依次使用乙醇和去离子水吹干;
(6)将吹干后的50g多孔海藻酸钠-聚乙烯醇凝胶膜浸没于55mmol羟乙基丙烯酰、1.43mmol三-(N,N-二甲氨基乙基)胺、60ml甲醇和50ml去离子水的混合溶液中,随后加入0.71mmol溴化亚铜,在氮气保护下,常温下反应12h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜;
(7)取重量份数为黄连8份,丹皮7份,徐长卿3份,苍耳子12份,蝉衣15份,白鲜皮5份,苦参12份,防风16份,枳壳5份,桔梗15份,土茯苓15份,荆芥5份和连翘10份十三味中药作为制备膏药层的原料,将上述十三味中药碾碎成细粉,混合后加入10倍重量的65%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.2的稠膏,然后将稠膏涂于步骤(6)所得聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
实施例3:贴膏剂的制备包括以下步骤:
(1)将70g海藻酸钠与20g聚乙烯醇溶于140g去离子水中,放置7h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入5g的2500目CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入0.6g含有3wt%CaCl2的饱和硼酸溶液,固化18h后干燥,得到厚度为4mm的海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入0.1mol/L盐酸水溶液中浸渍6h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将多孔海藻酸钠-聚乙烯醇凝胶膜浸没于1wt%3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在20℃下静置12h,随后依次使用乙醇和去离子水吹干;
(6)将吹干后的50g多孔海藻酸钠-聚乙烯醇凝胶膜浸没于50mmol羟乙基丙烯酰、1.48mmol三-(N,N-二甲氨基乙基)胺、60ml甲醇和60ml去离子水的混合溶液中,随后加入0.78mmol溴化亚铜,在氮气保护下,常温下反应10h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜;
(7)取重量份数为黄连6份,丹皮5份,徐长卿6份,苍耳子7份,蝉衣10份,白鲜皮15份,苦参8份,防风10份,枳壳10份,桔梗8份,土茯苓10份,荆芥13份和连翘5份十三味中药作为制备膏药层的原料,将上述十三味中药碾碎成细粉,混合后加入10倍重量的65%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.3的稠膏,然后将稠膏涂于步骤(6)所得聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
实施例4:贴膏剂的制备包括以下步骤:
(1)将100g海藻酸钠与20g聚乙烯醇溶于150g去离子水中,放置7h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入8.5g的800目CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入0.7g含有3wt%CaCl2的饱和硼酸溶液,固化24h后干燥,得到厚度为4mm的海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入0.09mol/L盐酸水溶液中浸渍3h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将多孔海藻酸钠-聚乙烯醇凝胶膜放浸没于1.3wt%3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在25℃下静置10h,随后依次使用乙醇和去离子水吹干;
(6)将吹干后的50g多孔海藻酸钠-聚乙烯醇凝胶膜浸没于50mmol羟乙基丙烯酰、1.57mmol三-(N,N-二甲氨基乙基)胺、40ml甲醇和60ml去离子水的混合溶液中,随后加入0.8mmol溴化亚铜,在氮气保护下,常温下反应18h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜;
(7)取重量份数为黄连9份,丹皮3份,徐长卿5份,苍耳子18份,蝉衣5份,白鲜皮10份,苦参17份,防风3份,枳壳8份,桔梗20份,土茯苓5份,荆芥9份和连翘15份十三味中药作为制备膏药层的原料,将上述十三味中药碾碎成细粉,混合后加入5倍重量的70%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.28的稠膏,然后将稠膏涂于步骤(6)所得聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
贴膏剂含膏量测定方法:将精密称定质量后的贴膏剂成品放入有盖玻璃仪器中,加入正己烷直至浸没,浸泡2-4小时后取出,再采用正己烷洗涤三次,将洗涤后的贴膏剂置于105℃下干燥0.5h,随后冷却,精密称定重量,计算减少的质量,按面积计算含膏量,其中含膏量在1.7g/100cm2以上符合药品检验要求。
含膏量(g/100cm<sup>2</sup>) | |
实施例1 | 1.82 |
实施例2 | 1.93 |
实施例3 | 1.95 |
实施例4 | 1.89 |
以上4个实施例的含膏量均大于1.7g/100cm2,因此均符合药品检验要求。
对比例1:与实施例1的区别在于,步骤(2)中不添加的CaCO3。
对比例2:与实施例1的区别在于,步骤(2)中添加的CaCO3的粒径为3000目。
对比例3:与实施例1的区别在于,步骤(2)中添加的CaCO3的粒径为400目。
将实施例1、对比例1和对比例2制备得到的透气抗菌基层分别进行透气性和强度测试,所得结果如下表所示。
透气系数(m<sup>2</sup>/s·kPa) | 拉伸强度(MPa) | |
实施例1 | 1.2 | 15.1 |
对比例1 | 0.76 | 17.4 |
对比例2 | 0.81 | 16.7 |
对比例3 | 1.7 | 6.5 |
由上表可知,相对于不添加CaCO3颗粒的对比例1,若添加的CaCO3的目数过大,例如对比例2,其透气系数上升较少,说明其透气性增长不明显;若添加的CaCO3的目数过小,例如对比例3,虽然其透气系数上升明显,但其拉伸强度大幅下降,而实施例1中,添加的CaCO3的目数适中,因此其透气抗菌基层具有较高的透气系数和拉伸强度。
对比例4:与实施例1的区别在于,步骤(4)所得多孔海藻酸钠-聚乙烯醇凝胶膜不进行聚羟乙基丙烯酰胺的接枝改性,直接作为贴膏剂的基层。
将实施例1中制备的透气抗菌基层与对比例4中所得未进行聚羟乙基丙烯酰胺的接枝改性的贴膏剂的基层置于大肠杆菌菌液中在37℃下恒温培养24h,染色后通过荧光显微镜探测不同基层中大肠杆菌的吸附量,所得数据如下表所示。
大肠杆菌粘附密度(个/cm<sup>2</sup>) | |
实施例1 | 4.1×10<sup>5</sup> |
对比例4 | 5.7×10<sup>6</sup> |
由上表可知,通过聚羟乙基丙烯酰胺的接枝改性后,基层大肠杆菌粘附密度明显下降,说明其具有较高的抗菌性能。
Claims (3)
1.一种治疗湿疹的中药贴膏剂,其特征在于,贴膏剂包括膏药层和透气抗菌基层,所述膏药层由以下重量份数的原料制成:黄连6-9份,丹皮3-7份,徐长卿3-6份,苍耳子7-18份,蝉衣5-15份,白鲜皮5-15份,苦参8-17份,防风3-16份,枳壳5-10份,桔梗8-20份,土茯苓5-15份,荆芥5-13份和连翘5-15 份,所述透气抗菌基层为聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜;
所述聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜的制备方法如下:
(1)将质量比为1-5:1的海藻酸钠与聚乙烯醇溶于去离子水中,放置5-7h至充分溶解,得到混合液;
(2)搅拌状态下在所得混合液中加入粒径为1400目的CaCO3颗粒;
(3)在步骤(2)中所得溶液滴入含有2-4wt% CaCl2的饱和硼酸溶液,固化12-24h后干燥,得到海藻酸钠-聚乙烯醇凝胶膜;
(4)将海藻酸钠-聚乙烯醇凝胶膜放入盐酸水溶液中浸渍3-6h,随后使用去离子水清洗,烘干后得到多孔海藻酸钠-聚乙烯醇凝胶膜;
(5)将羟乙基丙烯酰胺接枝于多孔海藻酸钠-聚乙烯醇凝胶膜的表面和孔壁上,具体包括以下步骤:
(a)将多孔海藻酸钠-聚乙烯醇凝胶膜放于3-(2-溴异丁酰胺基)正丙基三甲氧基硅氧烷的氯仿溶液中,在20-25℃下静置8-12h,随后依次使用乙醇和去离子水吹干;
(b)将吹干后的多孔海藻酸钠-聚乙烯醇凝胶膜置于羟乙基丙烯酰、三-( N, N-二甲氨基乙基) 胺和甲醇混合液中溶液中,所述羟乙基丙烯酰和三-(N,N-二甲氨基乙基)胺的摩尔比为30-35:1,随后加入溴化亚铜,所述羟乙基丙烯酰和溴化亚铜的摩尔比为60-70:1,在氮气保护下,常温下反应10-18h,随后将多孔海藻酸钠-聚乙烯醇凝胶膜取出,用蒸馏水清洗,烘干,得到聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜。
2.根据权利要求1所述一种治疗湿疹的中药贴膏剂,其特征在于,所述透气抗菌基层的厚度为3-5mm。
3.根据权利要求1所述贴膏剂的制备方法,其特征在于,包括以下制备步骤:
将制备膏药层的原料碾碎成细粉,混合后加入5-10倍重量的60-70%的乙醇溶液进行回流煎煮,随后过滤,将滤液浓缩至相对密度为1.2-1.3的稠膏,然后将稠膏涂于聚羟乙基丙烯酰胺接枝改性的多孔海藻酸钠-聚乙烯醇凝胶膜表面,随后切段,盖衬,得到贴膏剂成品。
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