CN109289001A - A kind of Chinese medicine composition and preparation method thereof for treating kidney stone - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating kidney stone Download PDFInfo
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- CN109289001A CN109289001A CN201811346734.XA CN201811346734A CN109289001A CN 109289001 A CN109289001 A CN 109289001A CN 201811346734 A CN201811346734 A CN 201811346734A CN 109289001 A CN109289001 A CN 109289001A
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating kidney stone, be made of raw material from the following weight: 20~30 parts of endothelium corneum gigeriae galli, 20~30 parts of pangolin, 30~50 parts of herba lysimachiae, 10~20 parts of caulis akebiae, 20~30 parts of husky ginger, 10~20 parts of talcum, 25~55 parts of kind peach leaf, 25~55 parts of flower of Japanese banana, 15~45 parts of syrup, clear and bright careless 15~45 parts, 5~35 parts of the rhizome of davallia, 5~35 parts of mantis egg-case, 1~15 part of refined honey also disclose preparation method.Has the function of synergy between the application raw material, have the function that prevent and treat kidney stone jointly, it dissolve stone and it can be promoted per urethram excretes, without kidney damage, have the function of clearing heat and detoxicating, anti-inflammatory, eliminate uronephrosis, while can be to because of impaired renal function after stone operation, with improvement result, can be very good treatment kidney stone, and it is quick, healing time is shorter, cure rate be 97~99%.
Description
Technical field
The invention belongs to pharmaceutical technology field more particularly to a kind of Chinese medicine composition for treating kidney stone and its preparation sides
Method.
Background technique
Kidney stone is a kind of common disease of urinary system, and male's morbidity is more than women, in certain In Limestone Areas because of it
Impurity is excessive in drinking water, and kidney stone Proportion of patients is more than 50%, Symptoms: calculus will affect abdomen when mobile with urine and carry on the back
Bitterly or blood urine, frequent micturition, urodynia are urinated unsmooth, and anuria can occur for serious person, renal function ceremonial dress for royalty exhausts, toxic shock.Influence calculus
There are many factor of formation, and age, sex, race, heredity, environmental factor, eating habit and occupation are related to the formation of calculus.Machine
The metabolic disorder of body, the obstruction of urinary tract, infection, the use of foreign matter and drug are the common disease factors of calculus.Known uropoiesis knot
Stone has 32 kinds of ingredients, and modal composition is calcium oxalate, and other compositions have ammonium magnesium phosphate, uric acid, calcium phosphate and Cystine etc..
Renal calcium oxalate calculus is most multiple, accounts for overall 90% or more calculus, and single water calcium oxalate crystal easily merges ureteral obstruction, high risks
Human health.
Drug therapy can slow down the formation of calcium oxalate crystals, but chemicals will appear some nausea and vomiting or height
The side effect of blood potassium.When pain cannot be alleviated by drug or calculus is relatively large in diameter, it is contemplated that take surgical intervention measure.Wherein wrap
It includes: 1. extracorporeal shock wave lithotripsy；2. placing bracket in ureter, ESWL can also be cooperated to treat；3. broken through ureteroscope
Stone stone-extraction operation；4. percutaneous nephrolithotomy；5. laparoscope Lithotomy.At present to severe person mostly with extracorporeal shock wave into
Row treatment can use drug fossil, row's stone method treatment compared with less serious case to the state of an illness.Operative treatment scheme is usually all wound, and there is also damages
Hurt the risk of surrounding tissue organ, intraoperative hemorrhage.According to statistics, having 50% or more patient with operation follow-up has recurrence, and cannot root
Except calculus, patient will face the torment of recurrent exerbation.
Understanding with people to plant and traditional Chinese medicine, everybody recognizes " integration of drinking and medicinal herbs ".Wish safety and takes
Extensive, the cheap pure natural edible plant fruits and vegetables class raw material of material are applied to research prevention and control disease areas,
Traditional Chinese medicine the reach of science will rapidly be promoted.
Currently, the treatment for the disease, therapeutic agent general treatment used is ineffective in the market, irritation is big,
It is easy to produce side effect, and Chinese medicine is used to treat, although avoiding irritating problem, therapeutic effect is undesirable, works
Slow or treatment cycle is long, such as: patent application CN201710566707.2 discloses a kind of Chinese medicine group that can treat kidney stone
Close object and preparation method thereof.Chinese medicine composition of the present invention includes deer horn glue, Cortex Eucommiae, Chinese gall, hairyvein agrimony, Fructus Corni, crow
It is plum, orange peel, fragrant citrus pericarp, pomelo peel, rhizoma nardostachyos, rush, R.hoofshaped, pyracantha fortuneana, Herba Coluriae longifoliae, dandelion, Radix Glycyrrhizae, Lygodium japonicum, peppery
Green pepper leaf, gardenia, tomato, meadow sweet, wormwood；Experiment and clinical confirmation the traditional chinese medicine composition of the invention treatment kidney stone have good
Effect.The more Chinese medicine but the patent application has been arranged in pairs or groups, higher cost, and preparation process are complicated, inconvenient for operation, no
Conducive to industrialized production.
Therefore, it is particularly important that a kind of novel drugs for treating calculus are developed.
Summary of the invention
The present invention is in order to solve the above technical problems, provide a kind of Chinese medicine composition for treating kidney stone and its preparation side
Method.Pharmaceutical composition of the present invention is pure Chinese medicinal preparation, and mild in medicine property is closed, have no toxic side effect, without any food prohibited, litholysis after
It not will cause internal residual, there is clearing heat and detoxicating, inducing diuresis for treating strangurtia, activating blood circulation and reducing swelling, coronary circulation-promoting pain-relieving, can increase urea, uric acid and chlorine
The effect of changing the excretion of sodium, can effectively treat kidney stone, and raw materials used source is wide, simple and easy to get, reduce production cost.
In order to reach purpose described above, the invention adopts the following technical scheme:
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 20~30 parts of endothelium corneum gigeriae galli wears mountain
20~30 parts of first, 30~50 parts of herba lysimachiae, 10~20 parts of caulis akebiae, 20~30 parts of husky ginger, 10~20 parts of talcum, kind peach leaf 25~55
Part, 25~55 parts of flower of Japanese banana, 15~45 parts of syrup, clear and bright 15~45 parts of grass, 5~35 parts of the rhizome of davallia, 5~35 parts of mantis egg-case, refining
1~15 part of honey.
Further, a kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: in chicken
Golden 21~29 parts, 21~29 parts of pangolin, 35~45 parts of herba lysimachiae, 11~19 parts of caulis akebiae, 21~29 parts of husky ginger, talcum 11~19
Part, 30~50 parts of kind peach leaf, 30~50 parts of flower of Japanese banana, 20~40 parts of syrup, clear and bright 20~40 parts of grass, 10~30 parts of the rhizome of davallia,
10~30 parts of mantis egg-case, 5~10 parts of refined honey.
Further, a kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: in chicken
Golden 25 parts, 25 parts of pangolin, 40 parts of herba lysimachiae, 15 parts of caulis akebiae, 25 parts of husky ginger, 15 parts of talcum, 40 parts of kind peach leaf, flower of Japanese banana 40
Part, 30 parts of syrup, clear and bright careless 30 parts, 20 parts of the rhizome of davallia, 20 parts of mantis egg-case, 3~13 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar.
Further, the rhizome of davallia is the wild rhizome of davallia rhizome being grown on trunk.
Further, a kind of preparation method of Chinese medicine composition that treating kidney stone, comprising the following steps:
(1) endothelium corneum gigeriae galli, pangolin, herba lysimachiae, caulis akebiae, husky ginger, the rhizome of davallia and mantis egg-case are weighed according to parts by weight, are washed
Only, after sunning is lower than 50% to water content, 1~2 times of herba lysimachiae weight of clear water, ultrasonic wave extraction is added, natural filtration separates,
Obtain filtrate and filter residue；
(2) filter residue of step (1) is added into clean kind peach leaf, flower of Japanese banana and clear and bright grass, be sent into dryer 30~
55~65min is dried at 40 DEG C, is sent into micronizer grind into powder；
(3) after talcum feeding micronizer being ground into talcum powder, syrup, refined honey, the filtrate of step (1) and step is added
Suddenly the powder of (2) is uniformly mixed, and preparation is made using conventional preparation techniques to get the Chinese medicine composition in microwave sterilization.
Further, in step (1), the power of the ultrasonic extracting process is 400~500W, frequency is 0.2~
0.6MHz, time are 20~25min.
Further, in step (2) and (3), the frequency of the grinding is 60~80Hz, grinding pressure is 0.3~
0.8MPa, revolving speed are 55~65r/min, and being ground to particle size is 1~10 μm.
Further, in step (3), the frequency of the microwave sterilization is 0.2~0.6KHz, and power is 600~700W, when
Between be 20~25min.
Further, in step (3), the preparation is tablet, pill, capsule, granule, electuary or oral solution.
The pharmacology analysis of each herbal medicine of the present invention is as follows:
Endothelium corneum gigeriae galli: returns spleen, stomach, small intestine, bladder meridian.Function: removing food retention, strengthening the spleen and stomach.The major functions: dyspepsia turgor, vomiting gastric disorder causing nausea,
Dysentery, infantile malnutrition due to digestive disturbances or intestinalparasites are quenched one's thirst, incontinence of urine, sore throat acute tonsillitis, noma aphtha.
Pangolin: return liver, stomach meridian, function: detumescence suppuration, scattered silt dredging collateral, promoting menstruation, lower cream, invigorating blood circulation analgesia.The major functions: ulcer
Sore swells, wind-cold-dampness arthralgia, menostasis, alactation, hemostasis, the accumulation of disease scab.
Talcum: return stomach, bladder meridian.Function: diuresis excreting dampness, clearing away summerheat.The major functions: summer-heat and damp is generated heat, difficult urination urinates red leaching
Drip.
Herba lysimachiae: return liver, kidney bladder meridian.Function: clearing damp and promoting diuresis, it is clearing heat and detoxicating.The major functions: nephritic dropsy, damp and hot, jaundice,
Lithangiuria, sore, carbuncle and painful swelling.
Caulis akebiae: return heart, small intestine, bladder meridian.Function: heat-clearing, Li Shui are promoted lactation.The major functions: bladder damp-heat, the fervid pain of oliguria,
Aphtha, vexed insomnia, foot are swollen.
Husky ginger: return heart, spleen, kidney channel.Function: middle benefit gas dehumidifying, promoting the circulation of qi helps digestion, analgesic.The major functions: coldness and pain in the epigastrium, cold-dampness is vomited and diarrhoea,
Cholera, fullness and oppression of chest and abdomen, diet do not disappear, toothache, rheumatic arthralgia.
Kind peach leaf: bitter, puckery；It is mild-natured.Function: drying damp and strengthening spleen；It is clearing heat and detoxicating.Master is rushed down: dysentery abdominal pain；Dyspeptic abdominal distention；Gums
Swelling and pain；Rheumatic arthralgia；Eczema ulcer on the shank；Furuncle swelling toxin；Treating swelling and pain by traumatic injury；Traumatic hemorrhage；Snakebite and bugbite." Nanning City's drug will ": it receives
Hold back antidiarrheal.Control diarrhea, protracted dysentery, eczema, wound hemorrhage.Guangzhou army " common Chinese herbal medicine handbook ": skin eczema, itch, heat are controlled
Miliaria.
Flower of Japanese banana: sweet what is said or talked about micro-pungent, it is cool；Bushing cool blood, removing blood stasis and acesodyne；Ease constipation, bushing.Slightly sweet flavor, micro-pungent, it is cool in nature；Have
The effect of resolving phlegm and softening hard masses, calming the liver and stasis of blood, promoting menstruation.
Clear and bright grass: it is sweet in flavor, it is mild-natured, it is distributed in lung channel.With expelling pathogenic wind from the body surface, the effect of preventing phlegm from forming and stopping coughing.It is chiefly used in cough ant phlegm, gas
Asthma, flu, favism, muscles and bones pain, abnormal leucorrhea, carbuncle swells etc..
The rhizome of davallia: bitter, temperature；Enter liver and kidney channel；Rich in effective components such as flavones, alkaloid, phenols, there is removing blood stasis and acesodyne, connect
Bone continues muscle, toothache, Low Back Pain, chronic diarrhea and other effects.There is the benefits of hard bone, kidney tonifying, promoting blood circulation, hemostasis.Control kidney deficiency chronic diarrhea and pain in the loins, rheumatism
Numbness pain, dentalgia, tinnitus, the bruise sudden strain of a muscle, bone fracture, ecphyaditis, alopecia areata, corn etc.." Guangxi Chinese medicinal herbal ": " sweet slight bitter is puckery, temperature ".
Mantis egg-case: it is sweet in flavor, salty, it is mild-natured；Return liver and kidney channel.Have effects that astringent sperm contracting urine, tonify the kidney and support yang it is middle.For cunning of passing out semen
Essence, enuresis frequent micturition, urine gonorrhoea." this is through meeting original ": " mantis egg-case, the special inducing astrigency of function, therefore man is deficient, impotence due to deficiency of the kidney, loses in dream
Essence, incontinence of urine gonorrhoea side are mostly used it.Shennong's Herbal says logical five leaching, diuresis water channel again, and lid takes lower burnt empty stagnant to let out."
Refined honey: Gan Ping, bowl spares moisturize, relieving spasm to stop pain, removing toxic substances.The water content of refined honey is then 1 16 or so.Refined honey
Have effects that protection is cardiovascular, anti-inflammation and sterilization, protection angiocarpy be one of important process of refined honey it can purify blood, removing
Cholesterol and triglycerides in blood, and the toxin in blood can be cleared up, leukaemia and hypertension and hyperlipidemia can be prevented
Occur, it is in addition beautiful in flavone compound also rich in, this substance can prevent blood vessel aging, rigid, it is to people
The artery sclerosis of class also has obvious prevention effect；Anti-inflammation and sterilization is also one of important effect of refined honey, and also there are many crude drugs for it
With ingredient king, the intracorporal a variety of viruses of people and bacterium are eliminated, them can be reduced, injury is generated to tissue, usually people go out
Existing gastritis when the common diseases such as enteritis and tracheitis, can eat of refined honey, it can allow human body malaise symptoms to subtract as early as possible more
Gently.The benefit that edible refined honey has relieving insomnia, improves digestive function, present people's life stress is big, work strain, often
There is the symptom had a sleepless night, at this moment can eat of refined honey more, she can allow the nerve of people to be adjusted, and can allow nervous anxiety
Mood is improved, the symptom for allowing her to have a sleepless night can also mitigate therewith, and in life, those are with neurasthenia and anxiety-depression
Crowd eats of refined honey more is also of great benefit to physical recovery；There are also obvious adjustment effects for stomach of the refined honey to the mankind, it is not single
It can promote enterogastric peristalsis, moreover it is possible to promote gastric acid and intestinal fluid secretion, the digestion and absorption of food in stomach can be accelerated, human body can be allowed to disappear
Change function to significantly improve, in addition refined honey can also relax bowel and defecation, can be usually to eat of refined honey not only and prevent just with detoxicating intestine more
It is secret can also weight-reducing, the stature of people can be allowed to become more and more slenderrer.
From the channel tropism of above-mentioned each herbal medicine, function, analysis is cured mainly as can be seen that most drugs have promoting diuresis for stranguria, heat-clearing
Diuresis, coronary circulation-promoting pain-relieving effect have very strong adaptability to treatment kidney stone, and some drugs have and middle QI invigorating, mediation property of medicine, emergency
Analgesic, detoxication complement each other between raw material after the collocation of the application and processing method processing, can enhance drug
Curative effect.
Since present invention employs above technical schemes, have the advantages that
(1) the scientific and reasonable collocation between the application raw material complements each other between raw material, has the function of synergy,
Have the function that prevent and treat kidney stone jointly；The drug energy dissolve stone simultaneously promotees it and per urethram excretes, no kidney damage, tool
There is clearing heat and detoxicating, anti-inflammatory, eliminate uronephrosis, while there can be improvement result to because of impaired renal function after stone operation,
Can be very good treatment kidney stone, and it is quick, healing time is shorter, cure rate be 97~99%.
(2) pharmaceutical composition of the present invention is pure Chinese medicinal preparation, and mild in medicine property is closed, had no toxic side effect, without any food prohibited, knot
Stone dissolution after not will cause internal residual, have clearing heat and detoxicating, inducing diuresis for treating strangurtia, activating blood circulation and reducing swelling, coronary circulation-promoting pain-relieving, can increase urea,
The effect of excretion of uric acid and sodium chloride, can effectively treat kidney stone, and raw materials used source is wide, simple and easy to get, reduce life
Produce cost.
(3) the application is by part material ultrasonic extraction, so that raw material active principle well dissolves out, using the mode of ultramicro grinding
Raw material is crushed to micron level, facilitates drug and enters human body, in addition in raw material be added pharmaceutically acceptable carrier and/or
Excipient --- syrup, therefore tablet, pill, capsule, granule, electuary or oral solution can be made, it is taken convenient for different patients
With preparation method is simple, at low cost.
(4) raw material used herein is the Chinese herbal medicine of integration of drinking and medicinal herbs, does not add any chemical raw material, has no toxic side effect,
It can be eaten for a long time, there is good efficacy to treatment kidney stone, can be used as treatment kidney stone drug, and be also used as protecting
Health food is formed for preventing kidney stone.
Specific embodiment
Specific embodiments of the present invention will be described in further detail below, but the invention is not limited to these realities
Mode is applied, it is claimed to still fall within the claims in the present invention for any improvement or replacement on the present embodiment essence spirit
Range.
Embodiment 1
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 30 parts of endothelium corneum gigeriae galli, pangolin 30
Part, 50 parts of herba lysimachiae, 20 parts of caulis akebiae, 30 parts of husky ginger, 20 parts of talcum, 55 parts of kind peach leaf, 55 parts of flower of Japanese banana, 45 parts of syrup, Clear and Bright
Careless 45 parts, 35 parts of the rhizome of davallia, 35 parts of mantis egg-case, 15 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.
A kind of preparation method of the Chinese medicine composition for the treatment of kidney stone as described above, comprising the following steps:
(1) endothelium corneum gigeriae galli, pangolin, herba lysimachiae, caulis akebiae, husky ginger, the rhizome of davallia and mantis egg-case are weighed according to parts by weight, are washed
Only, after sunning is lower than 50% to water content, 1~2 times of herba lysimachiae weight of clear water, ultrasonic wave extraction is added, natural filtration separates,
Obtain filtrate and filter residue；The power of the ultrasonic extracting process is 400~500W, and frequency is 0.2~0.6MHz, time 20
~25min；
(2) filter residue of step (1) is added into clean kind peach leaf, flower of Japanese banana and clear and bright grass, be sent into dryer 30~
55~65min is dried at 40 DEG C, is sent into micronizer grind into powder；
(3) after talcum feeding micronizer being ground into talcum powder, syrup, refined honey, the filtrate of step (1) and step is added
Suddenly the powder of (2) is uniformly mixed, and preparation is made using conventional preparation techniques to get the Chinese medicine composition in microwave sterilization；Institute
The frequency for stating microwave sterilization is 0.2~0.6KHz, and power is 600~700W, and the time is 20~25min；The preparation be tablet,
Pill, capsule, granule, electuary or oral solution.
Further, in step (2) and (3), the frequency of the grinding is 60~80Hz, grinding pressure is 0.3~
0.8MPa, revolving speed are 55~65r/min, and being ground to particle size is 1~10 μm.
Embodiment 2
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 20 parts of endothelium corneum gigeriae galli, pangolin 20
Part, 30 parts of herba lysimachiae, 10 parts of caulis akebiae, 20 parts of husky ginger, 10 parts of talcum, 25 parts of kind peach leaf, 25 parts of flower of Japanese banana, 15 parts of syrup, Clear and Bright
Careless 15 parts, 5 parts of the rhizome of davallia, 5 parts of mantis egg-case, 1 part of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Embodiment 3
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 21 parts of endothelium corneum gigeriae galli, pangolin 21
Part, 35 parts of herba lysimachiae, 11 parts of caulis akebiae, 21 parts of husky ginger, 11 parts of talcum, 30 parts of kind peach leaf, 30 parts of flower of Japanese banana, 20 parts of syrup, Clear and Bright
Careless 20 parts, 10 parts of the rhizome of davallia, 10 parts of mantis egg-case, 5 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Embodiment 4
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 29 parts of endothelium corneum gigeriae galli, pangolin 29
Part, 45 parts of herba lysimachiae, 19 parts of caulis akebiae, 29 parts of husky ginger, 19 parts of talcum, 50 parts of kind peach leaf, 50 parts of flower of Japanese banana, 40 parts of syrup, Clear and Bright
Careless 40 parts, 30 parts of the rhizome of davallia, 30 parts of mantis egg-case, 10 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Embodiment 5
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 25 parts of endothelium corneum gigeriae galli, pangolin 25
Part, 40 parts of herba lysimachiae, 15 parts of caulis akebiae, 25 parts of husky ginger, 15 parts of talcum, 40 parts of kind peach leaf, 40 parts of flower of Japanese banana, 30 parts of syrup, Clear and Bright
Careless 30 parts, 20 parts of the rhizome of davallia, 20 parts of mantis egg-case, 3~13 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Embodiment 6
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 22 parts of endothelium corneum gigeriae galli, pangolin 22
Part, 33 parts of herba lysimachiae, 12 parts of caulis akebiae, 22 parts of husky ginger, 12 parts of talcum, 35 parts of kind peach leaf, 35 parts of flower of Japanese banana, 25 parts of syrup, Clear and Bright
Careless 25 parts, 15 parts of the rhizome of davallia, 15 parts of mantis egg-case, 3 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Embodiment 7
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 28 parts of endothelium corneum gigeriae galli, pangolin 28
Part, 48 parts of herba lysimachiae, 18 parts of caulis akebiae, 28 parts of husky ginger, 18 parts of talcum, 45 parts of kind peach leaf, 45 parts of flower of Japanese banana, 35 parts of syrup, Clear and Bright
Careless 35 parts, 25 parts of the rhizome of davallia, 25 parts of mantis egg-case, 12 parts of refined honey.
Further, the kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar；The rhizome of davallia is
The wild rhizome of davallia rhizome being grown on trunk.Preparation method is same as Example 1.
Comparative example 1
A kind of Chinese medicine composition for treating kidney stone, is made of raw material from the following weight: 35 parts of endothelium corneum gigeriae galli, pangolin 45
Part, 60 parts of herba lysimachiae, 40 parts of caulis akebiae, 50 parts of husky ginger, 30 parts of talcum, 75 parts of kind peach leaf, 70 parts of flower of Japanese banana, 55 parts of syrup, Clear and Bright
Careless 60 parts, 50 parts of the rhizome of davallia, 55 parts of mantis egg-case, 45 parts of refined honey.Preparation method is same as Example 1.
Comparative example 2
It is carried out according to the embodiment in patent application CN201710566707.2.
Toxicity test
Small white mouse 30,20~25g of weight are taken, male and female dual-purpose is randomly divided into 2 groups, every group 15.Wherein one group is normal
Test group is measured, in addition five groups are super quantity test group.Normal amount test group dosage is 2mg/10g, and excess test group dosage is
4mg/10g, it is each primary daily morning and evening, it even eats one week, administration mode is stomach-filling, and observation is reacted after taking daily.The result shows that: it is each
Group mouse behavior is without exception, and the poisoning symptoms such as no dull, movable reduction, appetite, excrement are without exception, and general signs are good, table
The Chinese medicine composition product safety of bright treatment kidney stone of the invention has no toxic side effect.
Effect test
900 progress clinical tests of volunteer because suffering from kidney stone caused by a variety of causes are selected, under case selection meets
Column condition:
One, it is shown through B ultrasound, x-ray photo radiography or plain film kidney, ureter, bladder has calculus person；
Two, position property calculus size: 0.2~0.4cm, 0.5~0.8cm, 0.8~1.2cm person respectively；
Three, B ultrasound, x-ray photo have typical lithangiuria person, there is kidney stone and ponding person.
Symptom: urine has a pain, and time point drop-wise of urinating, kidney stone is larger, or crushed beat after or surgical site infections answer
Originator.Severe one: double shin calfs portion edema, dysuria, renal function are poor, and the shouting pain of kidney portion adds severe one when urine.
Male is 590, and women is 310, and the age, average age was 46 years old, and stochastic averagina is divided into 9 at 18~76 years old
Group, every group of 100 people respectively take Chinese medicine composition made from the embodiment of the present application 1~7 and comparative example 1~2 to each group patient
With observation patient takes effect.
Patient cures " the disease of tcm Standardization of diagnosis and curative effect " that validation criteria is formulated according to State Administration of Traditional Chinese Medicine:
One, confirm in urinary tract through B ultrasound, x-ray photo without calculus person；
Two, there is significantly row's stone symptom: as urine shouting pain, blood urine, serious person have renal colic person；
Three, calculus is per urethram discharged after treating, and leaves and takes calculus sample, dedicated bedpan attention.
To Chinese medicine composition made from patient daily Examples 1 to 7 and comparative example 1~2, each taking 10ml (or
Person 10g), 3 times a day, 20 are as a treatment course, continuously take 2 course for the treatment of.Observation treatment cure rate, experimental result such as the following table 1
It is shown.
Table 1
| Group | Average onset time | Average cure time | It cures | Effectively | In vain |
| Embodiment 1 | 7d | 35d | 93 | 97 | 3 |
| Embodiment 2 | 5d | 37d | 92 | 98 | 2 |
| Embodiment 3 | 6d | 36d | 94 | 98 | 2 |
| Embodiment 4 | 7d | 34d | 93 | 97 | 3 |
| Embodiment 5 | 4d | 33d | 95 | 99 | 1 |
| Embodiment 6 | 7d | 36d | 93 | 97 | 3 |
| Embodiment 7 | 6d | 35d | 95 | 98 | 2 |
| Comparative example 1 | 9d | 45d | 86 | 89 | 11 |
| Comparative example 2 | 7d | 43d | 90 | 97 | 3 |
By 1 experimental data of table it is found that the Chinese medicine composition cure rate that the application treats kidney stone is 97~99%, cure rate
Up to 99%, and treat can quick acting, generally taking can work once week, and it is shorter to cure the required time, average to exist
It can be cured after taking 35d, reduce the pain of patient；Compared with comparative example 2, various aspects are not much different the application, but this
Apply for that raw material sources are wide, preparation method is simple, and it is at low cost, it is more suitable for commercially producing.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, nothing
By from the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended
Claim rather than above description limit, it is intended that by the institute in the meaning and scope for the equivalent loins for falling in claim
It changes and includes within protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating kidney stone, which is characterized in that be made of raw material from the following weight: endothelium corneum gigeriae galli 20~
30 parts, 20~30 parts of pangolin, 30~50 parts of herba lysimachiae, 10~20 parts of caulis akebiae, 20~30 parts of husky ginger, talcum 10~20 part, kind
25~55 parts of peach leaf, 25~55 parts of flower of Japanese banana, 15~45 parts of syrup, clear and bright careless 15~45 parts, 5~35 parts of the rhizome of davallia, mantis egg-case 5
~35 parts, 1~15 part of refined honey.
2. a kind of Chinese medicine composition for treating kidney stone according to claim 1, which is characterized in that by following parts by weight
Raw material is made: 21~29 parts of endothelium corneum gigeriae galli, 21~29 parts of pangolin, 35~45 parts of herba lysimachiae, 11~19 parts of caulis akebiae, husky ginger 21~29
Part, 11~19 parts of talcum, 30~50 parts of kind peach leaf, 30~50 parts of flower of Japanese banana, 20~40 parts of syrup, clear and bright careless 20~40 parts, bone
Broken benefit 10~30 parts, 10~30 parts of mantis egg-case, 5~10 parts of refined honey.
3. a kind of Chinese medicine composition for treating kidney stone according to claim 1, which is characterized in that by following parts by weight
Raw material is made: 25 parts of endothelium corneum gigeriae galli, 25 parts of pangolin, 40 parts of herba lysimachiae, 15 parts of caulis akebiae, 25 parts of husky ginger, 15 parts of talcum, kind peach leaf 40
Part, 40 parts of flower of Japanese banana, 30 parts of syrup, clear and bright careless 30 parts, 20 parts of the rhizome of davallia, 20 parts of mantis egg-case, 3~13 parts of refined honey.
4. described in any item a kind of Chinese medicine compositions for treating kidney stone according to claim 1~3, it is characterised in that: described
Kind peach leaf is the tender shoots leaf of wild kind of peach；The refined honey is chaste tree nectar.
5. described in any item a kind of Chinese medicine compositions for treating kidney stone according to claim 1~3, it is characterised in that: described
The rhizome of davallia is the wild rhizome of davallia rhizome being grown on trunk.
6. a kind of preparation method for the Chinese medicine composition for treating kidney stone, which comprises the following steps:
(1) endothelium corneum gigeriae galli, pangolin, herba lysimachiae, caulis akebiae, husky ginger, the rhizome of davallia and mantis egg-case are weighed according to parts by weight, are cleaned, are dried in the air
It shines after being lower than 50% to water content, 1~2 times of herba lysimachiae weight of clear water, ultrasonic wave extraction is added, natural filtration separation obtains
Filtrate and filter residue；
(2) filter residue of step (1) is added into clean kind peach leaf, flower of Japanese banana and clear and bright grass, is sent into dryer at 30~40 DEG C
55~65min of lower drying is sent into micronizer grind into powder；
(3) after talcum feeding micronizer being ground into talcum powder, syrup, refined honey, the filtrate of step (1) and step is added
(2) powder is uniformly mixed, and preparation is made using conventional preparation techniques to get the Chinese medicine composition in microwave sterilization.
7. a kind of preparation method of Chinese medicine composition for treating kidney stone according to claim 6, it is characterised in that: in step
Suddenly (1), the power of the ultrasonic extracting process are 400~500W, and frequency is 0.2~0.6MHz, and the time is 20~25min.
8. a kind of preparation method of Chinese medicine composition for treating kidney stone according to claim 6, it is characterised in that: in step
Suddenly (2) and (3), the frequency of the grinding are 60~80Hz, and grinding pressure is 0.3~0.8MPa, and revolving speed is 55~65r/min,
Being ground to particle size is 1~10 μm.
9. a kind of preparation method of Chinese medicine composition for treating kidney stone according to claim 6, it is characterised in that: in step
Suddenly (3), the frequency of the microwave sterilization are 0.2~0.6KHz, and power is 600~700W, and the time is 20~25min.
10. a kind of preparation method of Chinese medicine composition for treating kidney stone according to claim 6, it is characterised in that:
Step (3), the preparation are tablet, pill, capsule, granule, electuary or oral solution.
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2018
- 2018-11-13 CN CN201811346734.XA patent/CN109289001A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 金强: "溶石排石汤治疗泌尿系结石40例", 《浙江中医学院学报》 * |
| 高尚炯: "《家庭实用土单验方》", 29 February 1996, 中国中医药出版社 * |
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