CN104366636A - Gynura procumbens compound preparation as well as preparation method and application thereof - Google Patents
Gynura procumbens compound preparation as well as preparation method and application thereof Download PDFInfo
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- CN104366636A CN104366636A CN201410593469.0A CN201410593469A CN104366636A CN 104366636 A CN104366636 A CN 104366636A CN 201410593469 A CN201410593469 A CN 201410593469A CN 104366636 A CN104366636 A CN 104366636A
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- gynura procumbens
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.
Description
Technical field
The invention belongs to field of health-care beverage, particularly a kind of Gynura procumbens (Lour.) Merr compound formulation and preparation method and application.
Background technology
In recent years, gout has become the more and more higher rich man's disease of the incidence of disease.Gout is also known as " hyperuricemia "
Because biosynthesis of purine metabolism increases, uric acid produces too much or because of the minimizing of RE uric acid, cause hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, causes and organizes foreign matter inflammatory reaction.Gout often accompanies Central obesity, carbohydrate disorders of lipid metabolism, hypertension, artery sclerosis and cardiovascular disease etc. to assemble generation.
Traditional treatment medicine is Western medicine, for the symptom selective therapy that patient with gout different times shows, but the toxic and side effect that ubiquity is serious, as anti-inflammation analgesis medicament colchicin is used for acute attack stage can pain relieving rapidly, but there is overt toxicity to marrow, liver, kidney, can leukaemia be caused; Excretion uric acid medicine probenecid is used for intermittent phase and chronic phase treatment, but responds to intestines and stomach and swash gouty attack,acute; Allopurinol, as the medicine of prevention gout outbreak, also makes medical circle promote to the toxicity of hepatic and renal function and marrow; Other as anti-inflammatory, hormone medicine also can only be the interim pain relieving of " treat the head when the head aches, pin pain cure pin ", and toxic and side effect is also clearly, causes the awkward situation of " take medicine and be impairment of the kidney, do not eat recurrence ".
Because Western medicine side effect is large, also need strict dieting, patient with gout is difficult to adhere to taking.And conventional medicament generally can only single pain relieving deacidification, and gout complication (gouty hypertension, diabetes, vascular sclerosis and hyperlipemia, lithangiuria) is felt simply helpless, can only develop as one pleases.Unbearably, want to treat gout by surgery, but surgical healing rate is very low, postoperative recurrence frequency is high for a lot of patient pain, produces multiple complications, causes body and mind more major injury.
These are all defectiveness in treatment, the bottleneck that kind is few, narrow application range, weak curative effect, side effect become greatly its clinical practice.Treatment gout makes medical circle in a dilemma, and patient with gout also finally can not break away from wrecking of the serious illness.
Along with economic development and lifestyle change, its illness rate rises gradually.According to statistics, existing nearly 9,000 ten thousand patient with gout of China, potential patient 1.2 hundred million, 90% concentrates on the male sex between 25-65 years old, the gout incidence of disease also rises year by year in the speed with annual 10% and in the trend of rejuvenation, has now become second largest threat human life and healthy metabolic system disease.
Therefore, its drug therapy and new drug development more and more cause the attention of people.Therefore antigout class medicine is very large in China market potentiality, but antigout class medicine mostly in the market is old medicine, imitation medicine, expensive and side effect is obvious.Can the novel drugs of comprehensive, safe and effective solution gout problem release if had, market prospects are by considerable in good time.
Summary of the invention
In order to solve above technical problem, the invention provides a kind of Gynura procumbens (Lour.) Merr compound formulation and preparation method and application, preparation safety, health, natural, there is multiple efficacies, be applied to comprehensive, the anti-treatment gout of multipath, adjustment uric acid metabolism can be played to gout, promote uric acid excretion, prevent uric acid crystal, anti-inflammatory analgetic, control the effect of stage of attack arthralgia, swelling and inflammation, decrease blood lipid blood sugar, strengthens renal metabolism, also has the feature of natural compound, natural Health preservation.Preparation method is simple, convenient, the maximum original composition maintaining raw material, green natural.
Solve a kind of Gynura procumbens (Lour.) Merr compound formulation in the present invention of above technical problem, it is characterized in that: described compound closes preparation and is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 75-85%, barley seedling 5-10%, lophatherum gracile 3-6%, frosted mulberry leaf 2-5%, root of kudzu vine 2-4%, Poria cocos 1-3%.
Compound formulation described in prioritization scheme is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 77-82%, barley seedling 5-8%, lophatherum gracile 4-5%, frosted mulberry leaf 2-4%, root of kudzu vine 2-3%, Poria cocos 2-3%.
Further, more excellent scheme can be made up of following percentage by weight raw material by described compound formulation: Gynura procumbens (Lour.) Merr 80%, barley seedling 8%, lophatherum gracile 4%, frosted mulberry leaf 3%, the root of kudzu vine 3%, Poria cocos 2%.
Gynura procumbens (Lour.) Merr: Gynura procumbens (Lour.) Merr is the health care plant of dietotherapeutic, containing multiple flavones, steroids, chlorogenic acid, linoleic acid plus linolenic acid and water-soluble dietary fiber.Clearing and activating the channels and collaterals, anti-inflammatory analgetic; Anti-nucleic acid oxidation, suppresses purine to generate, promotes uric acid excretion, alleviate gout, protect the liver and protect kidney.Blood uric acid can be reduced at high lithemia asymptomatic stage, promote uric acid metabolism, prevent uric acid crystal, dissolve the calculus urate formed, simultaneously can anti-inflammatory analgetic, control stage of attack arthralgia, swelling and inflammatory reaction, all effect is improved to the gout of acute stage and intermittent phase, to reducing blood fat, softening blood vessel, reducing blood pressure, promoting microcirculatory effect.
Barley seedling: barley seedling is rich in mineral matter, can effectively in and human body day by day slant acidity body fluid and be called as " king of basic food ".Patient with gout itself has purine metabolic disturbance uric acid abnormal, if too much eat acid food can increase the weight of the state of an illness, be unfavorable for rehabilitation, and eat base-forming food more and can help to supplement potassium sodium chlorion, maintain acid-base balance, long-term edible blood and the urine of can alkalizing, reduce blood uric acid, increase uric acid excretion, will joint, the urate crystal neutralization at soft tissue place, dissolving, discharge be deposited on, thus effectively reduce gout outbreak.
Lophatherum gracile: heat-clearing, clearing damp diuresis, gets rid of uric acid.There is effect of the relieving restlessness that clears away heart-fire, inducing diuresis for treating strangurtia, accelerate uric acid and discharge with urine, can be used for pyreticosis restlessness and thirst, spiritlessness and weakness, hot urination, the diseases such as aphthae.
Frosted mulberry leaf: anti-inflammatory heat-clearing, Li Shui purifies the blood; Li Shui effect is different from diuresis, not only can promote to urinate, and the excessive moisture amassed in cell can also be made to drain.
The root of kudzu vine: containing compositions such as kudzu root flavone, daucosterol, amino acid, uric acid can be suppressed to be formed, again can hemangiectasis, improves kidney blood circulation, and control uric acid crystal amasss in subcutaneous, among thin vessels and joint.
Poria cocos: softening blood vessel, reduces blood fat, regulates acid-base balance, promotes eubolism in body.
The preparation method of medicine composite preparation in Gynura procumbens (Lour.) Merr in the present invention, is characterized in that: comprise the following steps:
(1) prepare raw material and weigh: choosing fresh, clean Gynura procumbens (Lour.) Merr base of leaf and whole strain plant, cleaning and sterilizing;
(2) dry, 45-55 DEG C, 30-40min;
(3) with fresh Gynura procumbens (Lour.) Merr Weight computation, when Gynura procumbens (Lour.) Merr dehydration is to water content 55-63%, the sections of 0.7-1.5cm length is cut into, little fire cures again, as water content 5-10%, and slightly burnt odor taste time stop cure, for subsequent use after cooling, now sections can be fractureed easily;
Be dewatered to 55-63%, most of moisture is removed, when being convenient to frying, moisture evaporation is faster, saves time and fuel.Until sections can be fractureed easily, be convenient to long-term preservation.Slightly burnt odor taste, makes mouthfeel better.
(4) cooled Gynura procumbens (Lour.) Merr in barley seedling, lophatherum gracile, frosted mulberry leaf, the root of kudzu vine, Poria cocos and step (3) is ground into particle respectively, then mixes;
(5) by the above-mentioned composition of medicine mixed, then the compound formulation of tea in bag, oral liquid, capsule, tablet, powder, particle or other pharmaceutically acceptable formulation is made on request.
Described sections is the sections of 0.7-1.5cm length.
Grain diameter in described step (4) is 1-6mm.
Described lophatherum gracile replaces with cogongrass rhizome, heart of a lotus seed benevolence or corn stigma, and frosted mulberry leaf replaces with Asiatic plantain or desmodium.
The described root of kudzu vine replaces with Chinese yam or the bark of eucommia, and Poria cocos replaces with the Radix Astragali or Gorgon fruit.
Need to pick decontamination before raw material chopping, when pulverizing is to use, nutritional labeling is separated out more abundant, and particle is too large, and composition is not easy whole release, and particle is too little, easily makes soup look muddy, affects mouthfeel.Or it is easy to use when making other formulation.
Described compound formulation in the present invention can be applicable to prevent and treat gout.
According to the mechanism that uric acid produces, prevent and treat the generation that gout will reduce uric acid, reduced the purine in body, strengthen the eliminating of uric acid simultaneously.Traditional gout medicine, as colchicin, has overt toxicity to marrow, liver kidney.The dilemma that all gout patients are all faced with " fearness of taking medicine is harmful to the health, and does not eat and is afraid of recurrence ".Cure the symptoms, not the disease, can only temporary relieve pain, non-evident sympton after entering the gout intermittent phase, but in body, uric acid continues higher, easily delays the best opportunity for the treatment of especially.Compound preparation formula of the present invention carries out overall co-ordination from raw material and consumption, increase and metabolic stress according to gout generation principle and uric acid, nurse one's health from the generation of uric acid and excretion system, reduce uric acid to generate, the unification of kidney triple effect is supported in deacidification lipopenicillinase, treat both principal and secondary aspect of disease, thus reach the object of invention.Such as do not have Gynura procumbens (Lour.) Merr: anti-inflammatory analgesic effect is not obvious, it is not obvious that uric acid level and blood pressure and blood lipoid reduce amplitude.There is no large wheat straw: the PH value of uric acid is higher, and fall is large not.Wherein, Gynura procumbens (Lour.) Merr, suppresses purine to produce, prevents uric acid crystal, anti-inflammatory analgesic; Barley seedling, balance blood and urine pH value; Frosted mulberry leaf, releasing uric acid; Lophatherum gracile, diuresis; Gynura procumbens (Lour.) Merr, the root of kudzu vine, Poria cocos, strengthen renal metabolism.Work in coordination with onset through scientific compatibility, be different from the interim pain relieving of conventional medicament " treat the head when the head aches, pin pain cure pin ", but solve gout problem from source, more can effectively avoid gout to recur.Effectively can remove interior free yl, get rid of vivotoxin, anti-oxidant, remove cholesterol, promote sugar metabolism, reduce blood sugar and glucose in urine, resist the injury of various toxin to kidney and nervous centralis, stop the generation of complication.
Compound preparation in the present invention adopts the health care plant of dietotherapeutic, follows the nutrition and health care theory of integration of drinking and medicinal herbs, in conjunction with other natural drug, natural curing, safe no dependence, and there is good health-care effect, be more suitable for patient with gout and people at highest risk's long-term taking.Comprehensive reservation natural nutrient component, superelevation absorption rate, mouthfeel is better, and effect is more obvious.
Total effect:
1. regulate human body purine metabolism, reduce the synthesis of purine, effectively control high lithemia;
2. alkalize blood and urine pH value, promotes uric acid to decompose and excretion, reduce blood uric acid, prevent gout from showing effect;
3. effectively dissolve calculus urate, prevent uric acid crystal, prevention lithate deposits the destruction of joint and kidney damage that cause;
4. anti-inflammation detumescence, clearing and activating the channels and collaterals, control arthralgia, swelling and inflammatory reaction, prevention urarthritis;
5. adjusting blood lipid, blood sugar, maintenance cardiovascular and cerebrovascular is healthy, prevention gout complication;
6. balanced nutritious, improve metabolism, develop immunitypty, promote body energy.
The present invention has quick-acting antalgesic, promotes human acid-base balance, and the effect of dredging RE uric acid, obviously can recover serum uric acid level, reduce the recurrent exerbation of gout, advantage without any side effects and effect.And preparation technology is simple, raw material sources are wide, are easy to realize industrial scale and produce
Detailed description of the invention
Embodiment 1
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 75, barley seedling 10, lophatherum gracile 5, frosted mulberry leaf 4, the root of kudzu vine 3, Poria cocos 3, and preparation method comprises the following steps:
(1) prepare raw material and weigh: choosing fresh, clean Gynura procumbens (Lour.) Merr base of leaf and whole strain plant, putting into rinsing maching and carry out cleaning and sterilizing with often liter containing 0.8-1.2mg/L Ozone Water;
(2) with fresh Gynura procumbens (Lour.) Merr Weight computation, dry, 50 DEG C, 35min;
(3) make Gynura procumbens (Lour.) Merr dewater to water content 55-63% time, be cut into the sections of 1cm length, cure with the little fire of iron pan, as water content 5-10%, and slightly burnt odor taste time stop cure, cooling after for subsequent use, now sections can be fractureed easily;
Be dewatered to 55-63%, most of moisture is removed, when being convenient to frying, moisture evaporation is faster, saves time and fuel.Until during moisture 5-10%, be convenient to long-term preservation.Slightly burnt odor taste, makes mouthfeel better.
(4) cooled Gynura procumbens (Lour.) Merr in barley seedling, lophatherum gracile, frosted mulberry leaf, the root of kudzu vine, Poria cocos and step (3) is ground into the particle of 5mm length respectively, then mixes;
Raw material is dry product, needs to pick decontamination before chopping.When pulverizing is to use, nutritional labeling is separated out more abundant, and particle is too large, and composition is not easy whole release, and particle is too little, easily makes soup look muddy, affects mouthfeel.
(5) by the above-mentioned composition of medicine mixed, load and filter that tea bag is soaked drinks, 5 grams every bag.Every day 3 times, each time of morning, noon and afternoon, each 1 bag, 200ML boiling water brews 5-8 minute offspring's tea-drinking and uses.
Embodiment 2
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 85, barley seedling 5, lophatherum gracile 3, frosted mulberry leaf 2, the root of kudzu vine 2, Poria cocos 3, and preparation method comprises the following steps:
(1) prepare raw material and weigh: choosing fresh, clean Gynura procumbens (Lour.) Merr base of leaf and whole strain plant, putting into rinsing maching and carry out cleaning and sterilizing with often liter containing 0.8-1.2mg/L Ozone Water;
(2) with fresh Gynura procumbens (Lour.) Merr Weight computation, dry, 45 DEG C, 40min;
(3) make Gynura procumbens (Lour.) Merr dewater to water content 60% time, be cut into the sections of 0.7cm length, cure with the little fire of iron pan, as water content 5-10%, and slightly burnt odor taste time stop cure, cooling after for subsequent use, now sections can be fractureed easily;
(4) cooled Gynura procumbens (Lour.) Merr in barley seedling, lophatherum gracile, frosted mulberry leaf, the root of kudzu vine, Poria cocos and step (3) is ground into the particle of 1mm length respectively, then mixes;
(5) by the above-mentioned composition of medicine mixed, load and filter that tea bag is soaked drinks, 5 grams every bag.Every day 3 times, each time of morning, noon and afternoon, each 1 bag, 200ML boiling water brews 5-8 minute offspring's tea-drinking and uses.
Embodiment 3
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 78, barley seedling 6, lophatherum gracile 6, frosted mulberry leaf 5, the root of kudzu vine 4, Poria cocos 1, making and use method is as embodiment 1.
Embodiment 4
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 82, barley seedling 8, lophatherum gracile 4, frosted mulberry leaf 2, the root of kudzu vine 2, Poria cocos 2, making and use method is as embodiment 2.
Embodiment 5
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 77, barley seedling 8, lophatherum gracile 5, frosted mulberry leaf 4, the root of kudzu vine 3, Poria cocos 3, and preparation method comprises the following steps:
(1) prepare raw material and weigh: choosing fresh, clean Gynura procumbens (Lour.) Merr base of leaf and whole strain plant, putting into rinsing maching and carry out cleaning and sterilizing with often liter containing 0.8-1.2mg/L Ozone Water;
(2) with fresh Gynura procumbens (Lour.) Merr Weight computation, dry, 55 DEG C, 30min;
(3) when making Gynura procumbens (Lour.) Merr dewater to water content 60%, be cut into the sections of 1.5cm length, cure with the little fire of iron pan, until sections can be fractureed easily, similar moisture is completely without, and slightly burnt odor taste, for subsequent use after cooling;
Be dewatered to 60%, most of moisture is removed, when being convenient to frying, moisture evaporation is faster, saves time and fuel.Until moisture completely without, be convenient to long-term preservation.Slightly burnt odor taste, makes mouthfeel better.
(4) cooled Gynura procumbens (Lour.) Merr in barley seedling, lophatherum gracile, frosted mulberry leaf, the root of kudzu vine, Poria cocos and step (3) is ground into the particle of 4mm length respectively, then mixes;
Raw material is dry product, needs to pick decontamination before chopping.When pulverizing is to use, nutritional labeling is separated out more abundant, and particle is too large, and composition is not easy whole release, and particle is too little, easily makes soup look muddy, affects mouthfeel.
(5) by the above-mentioned composition of medicine mixed, put into tank, the appropriate big fire that adds water is fried boiling, then with half an hour at a simmer, leaches liquid; Add water in the dregs of a decoction and again decoct half an hour, then leach liquid; Twice liquid mixing.Respectively drink 1 time in afternoon in the morning in the evening.
Embodiment 6
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 80; barley seedling 8, lophatherum gracile 4, frosted mulberry leaf 3, the root of kudzu vine 3, Poria cocos 2; in other preparation method, content is as embodiment 1; the composition of medicine mixed is ground into 80 order powder; get sucrose and the dextrin mixed powder (3:1) of powder process again, in one-step-granulating method, be mixed and made into particle.Particle is crossed 70 mesh sieves on pelletizing machine, by the particle after whole on pelletizing machine, sprays in the volatile oil solution that appropriate ethanol dissolves, mix, pack with particles packing machine, 3 grams every bag.Every day 2-3 time, each 1 bag, 30 days is a treatment, and hot water is taken after mixing it with water.
Embodiment 7
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 80, barley seedling 5, lophatherum gracile 5, frosted mulberry leaf 4, the root of kudzu vine 3, Poria cocos 3, other preparation method is as embodiment 1, again the composition of medicine mixed is ground into 80 order powder, add 8 dolomols, encapsulated after mixing, 1 gram/.Oral every day 2-3 time, each 3 30 days is a course for the treatment of.
Embodiment 8
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 80, and barley seedling 8, lophatherum gracile 4, frosted mulberry leaf 3, the root of kudzu vine 3, Poria cocos 2, preparation and application is as embodiment 1.
Embodiment 9
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 79, and barley seedling 8, lophatherum gracile 4, frosted mulberry leaf 3, the root of kudzu vine 3, Poria cocos 3, preparation and application is as embodiment 1.
Embodiment 10
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 81, and barley seedling 7, lophatherum gracile 5, frosted mulberry leaf 2, the root of kudzu vine 3, Poria cocos 2, preparation and application is as embodiment 1.
Embodiment 11
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 81, and barley seedling 7, lophatherum gracile 5, frosted mulberry leaf 2, the root of kudzu vine 3, Poria cocos 2, preparation and application is as embodiment 1.
Embodiment 12
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 81, and barley seedling 7, cogongrass rhizome or corn stigma 5, Asiatic plantain 2, Chinese yam 3, the Radix Astragali 2, preparation and application is as embodiment 1.
Embodiment 13
Compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 81, and barley seedling 7, heart of a lotus seed benevolence 5, desmodium 2, the bark of eucommia 3, Gorgon fruit 2, preparation and application is as embodiment 1.
Test 1: animal toxicity experiment of the present invention
Get rabbit 20, body weight 2-2.5kg, divide two groups, often organize 10, wherein one group is overdose test group, and another group is normal amount test group.Adopt and decoct formulation, the content in embodiment 5 and preparation method, administration by gavage administration, super quantity group is 60ml/kg, and normal amount is 30ml/kg every day 2 times, continuous 7 days, observation administration is reacted, and show two groups of rabbit activities, diet is normal, medicine is without bad toxic and side effect.
Test one: efficacy experiment
1, diagnostic criteria
1. asymptomatic hyperuricemia: the generation Chang Shifen of hyperuricemia is hidden to be attacked, the initial stage is be interrupted to occur, gradually in continuation, is not intended to find more than health check-up or when going to a doctor because other are sick.
2. acute gouty arthritis: this has feature most and common symptom for gout, onset is hurried, can be there is obvious redness, heat pain in affected joints within a few hours, normal in night-time attack, wake up because of joint severe pain, local joint can not touch because of pain, even can not lid sheet, limitation of activity.Being most predilection site with foot first sole of the foot toe, is secondly other Minor articulus, ankle, knee, wrist, elbow, the shoulder joint of brothers.Initial stage mostly is simple joint pathology, and both sides alternately occur, and the later stage can be multi-joint pathology, occurs simultaneously or successively.Eat and drink immoderately, drink beyond one's capacity, fatigue, infection, wound, operation, wound, periarticular pressurized, footwear are carried out and uncomfortable etc. all be can be risk factor.Acute attack symptom continues more than one week, then alleviates gradually.After local joint redness disappears, skin can be had to itch, peel, pigmentation.Stage of attack, constitutional symptom can have heating, weak, increased heart rate, headache etc.
3. the gout intermittent phase: the gout intermittent phase refers to the interval of twice acute gouty arthritis outbreak, short then several weeks, long then many decades.Once in a while after some patients the 1st acute arthritis again without outbreak, majority is from long to short.The intermittent phase state of an illness is relatively steady, is also called inactive state.Some patients is uncomfortable after can having former affected joints activity, can alleviate after rest.Still can have hyperuricemia, affect by diet and treatment situation, serum uric acid level is unstable.
4. chronic gravel gout: long-term hyperuricemia fails to correct, and urate crystal extensively can be deposited on articular cartilage, synovial membrane, ligament, subcutaneous, kidney, forms urate calculi gradually, heavy then affect the physiological function of deposition fabric.After wherein the established calculus uric acid of part obtains control, still can melt, reduce, disappear even completely, this is comparatively special the lapsing to of gouty calculus.
5. subcutaneous tophus tubercle: be deposited on subcutaneous formation by urate crystal, be apt to occur in helix, joint periphery (toe, interphalangeal joint, knee joint, elbow joint, wrist joint etc.), tubercle differs in size, sesame size to 1 ~ 2 centimetre major tubercle, irregularity boundary, matter is hard, and table superficial part position is yellow-white.Tubercle well-defined with perienchyma, without touching a tender spot, but as merged bacteriological infection, can have perienchyma's redness, tenderness, having ulceration mouth more.Stone composition is taken out in acupuncture or ulceration secretion microscopy is lithate knot
Brilliant.
6. gouty arthritis,chronic: repeated multiple times acute arthritis shows effect the joint tissue fibrillatable and tophus that cause in the deposition of articular cartilage, synovial membrane, ligament, makes pathology joint damaged deformation gradually, loses motor function.Toe, interphalangeal joint, ankle, knee, wrist joint are easily got involved.
7. chronic gouty nephropathy and kidney stone: urate crystal deposits 2 kinds of forms at kidney, comprises too high can not the discharge in time of uric acid concentration in the not enough renal tubule apurinic acid mineralization (in medullary interstitium, renal tubule, uric acid concentration is normal) that causes of uric acid secretion excretion and renal tubule and lithate deposition in the renal tubule that is detained.Chronic Uric-acid Nephropathy can in these two kinds of uric acid kidneys deposition pattern basis on occur, majority is after the acute gouty arthritis of recurrent exerbation, and minority can occur on the basis only having long-term hyperuricemia.
2, the clinical observation material of drug therapy gout of the present invention
The patient of this observation is totally 58 examples, is all the male sex, the oldest person 75 years old, age reckling 24 years old, the most elder of the course of disease 27 years, the shortest half a year.
Table 1 patient profiles analyzes
Table 2 first attack cause analysis
Table 3 Analysis On Complications
Other performance of table 4 is analyzed
The analysis of table 5 painful area
3, methods for the treatment of
Brew to patient's boiling water and drink product of the present invention, evening each 1 time in afternoon in the morning, each 1 pouch 15 days is a course for the treatment of, takes 6 courses for the treatment of continuously.
4, efficacy assessment standard
Cure: transference cure, physique recovers normal, observes half a year without recidivist;
Take a turn for the better: arthroncus is cut down, pain relief, and physique is progressively recovered;
Invalid: symptom is unchanged.
5, efficacy analysis
58 routine patient with gout, cure 32 examples, cure rate 55%, and take a turn for the better 23 examples, improvement rate 40%, invalid 3 examples, total effective rate 95%.
Table 6 efficacy analysis
Table 7 treats front and back blood uric acid and clinical manifestation analysis
6, typical case analysis:
Open xx, man 46 years old, people from Shandong, for many years, be busy with one's work, dinner party is many in trade, often drink, suffer from goat 12 years, four limbs multi-joint is in continuing outbreak, and length takes colchicin medicine, in many ways to see the doctor for treatment unsatisfactory curative effect, pain relief when taking medicine of the present invention 20 days, 50 days complete and pain frees, do not recur so far again.
Fan XX, 52 years old, people from Sichuan, houses market portion is responsible for, and operating pressure is large, and often work overtime, dinner party is many, gout 9 years, and the outbreak of performance biped redness and swelling of joints pain is frequent, and with renal dysfunction.Can to stand during acute attack walking, uric acid level 503 μm of ol/L.Take the present invention and remove joint part uric acid crystal fast after 15 days, pain relief, joint pigment subtracts light, energy independent ambulation, when taking 35 days, joint part tophus tubercle disappears completely, after taking 90 days, uric acid level reduces to 390 μm of ol/L normal range (NR)s, and gout does not recur again, and gout complication also disappears.
The present invention chooses natural Chinese traditional medicines formula, this integration of drinking and medicinal herbs kind of special interpolation Gynura procumbens (Lour.) Merr, for the medicine of prevention and therapy hyperuricemia and gout, and has synergistic therapeutic action to the complication that gout causes, evident in efficacy, stable, effect that safety has no side effect.The present invention is with low cost, convenient to use, applied widely.
In order to solve above technical problem, the invention provides a kind of safety, healthy, natural, there is the comprehensive of multiple efficacies, the Gynura procumbens (Lour.) Merr compound Chinese medicinal preparation of multipath treatment gout and preparation method, adjustment uric acid metabolism can be played to gout, promote uric acid excretion, prevent uric acid crystal, anti-inflammatory analgetic, control stage of attack arthralgia, the effect of swelling and inflammation, there is adjusting blood lipid simultaneously, blood sugar, reduce blood to glue, prevent blood lipid deposition, maintenance cardiovascular and cerebrovascular is healthy, prevention gout complication, treat both principal and secondary aspect of disease and reach anti-antipodagric effect, also there is disinfection, improve immunity and metabolic effect.
Claims (9)
1. a Gynura procumbens (Lour.) Merr compound formulation, is characterized in that: described compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 75-85%, barley seedling 5-10%, lophatherum gracile 3-6%, frosted mulberry leaf 2-5%, root of kudzu vine 2-4%, Poria cocos 1-3%.
2. a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 1, it is characterized in that: described compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 77-82%, barley seedling 5-8%, lophatherum gracile 4-5%, frosted mulberry leaf 2-4%, root of kudzu vine 2-3%, Poria cocos 2-3%.
3. a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 2, is characterized in that: described compound formulation is made up of following percentage by weight raw material: Gynura procumbens (Lour.) Merr 80%, barley seedling 8%, lophatherum gracile 4%, frosted mulberry leaf 3%, the root of kudzu vine 3%, Poria cocos 2%.
4. the preparation method of a kind of Gynura procumbens (Lour.) Merr compound formulation according to any one of claim 1-3, is characterized in that: comprise the following steps:
(1) prepare raw material and weigh: choosing fresh, clean Gynura procumbens (Lour.) Merr base of leaf and whole strain plant, cleaning and sterilizing;
(2) dry, 45-55 DEG C, 30-40min;
(3) with fresh Gynura procumbens (Lour.) Merr Weight computation, when Gynura procumbens (Lour.) Merr dehydration is to water content 55-63%, be cut into the sections of 0.7-1.5cm length, less fire cures, as water content 5-10% and slightly stop during burnt odor taste curing, for subsequent use after cooling;
(4) cooled Gynura procumbens (Lour.) Merr in barley seedling, lophatherum gracile, frosted mulberry leaf, the root of kudzu vine, Poria cocos and step (3) is ground into particle respectively, then is mixed into composition of medicine;
(5) by the above-mentioned composition of medicine mixed, then the compound formulation of tea in bag, oral liquid, capsule, tablet, powder, particle or other pharmaceutically acceptable formulation is made on request.
5. the preparation method of a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 4, is characterized in that: described sections is the sections of 0.7-1.5cm length.
6. the preparation method of a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 4, is characterized in that: the grain diameter in described step (3) is 1-6mm.
7. a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 1, is characterized in that: described lophatherum gracile replaces with cogongrass rhizome, heart of a lotus seed benevolence or corn stigma, and frosted mulberry leaf replaces with Asiatic plantain or desmodium.
8. a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 1, it is characterized in that: the described root of kudzu vine replaces with Chinese yam or the bark of eucommia, Poria cocos replaces with the Radix Astragali or Gorgon fruit.
9. the application of a kind of Gynura procumbens (Lour.) Merr compound formulation according to claim 1, is characterized in that: described compound formulation is applied to prevents and treats gout.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036680A (en) * | 2007-04-08 | 2007-09-19 | 谢平 | Gynura procumbens troche and method for preparing the same |
| CN102366512A (en) * | 2011-09-04 | 2012-03-07 | 成都绿迪科技有限公司 | Traditional Chinese medicinal formula for treating gout |
| CN102908403A (en) * | 2012-11-13 | 2013-02-06 | 广东新大枫化工科技有限公司 | Chinese materia medica preparation for treating gout and preparation method thereof |
| KR101361846B1 (en) * | 2013-02-14 | 2014-02-13 | 강원대학교산학협력단 | Atural plant composition for modulate enzyme mrna relate to glucose metabolism in cell |
| CN103623099A (en) * | 2013-11-28 | 2014-03-12 | 王未境 | Sweet tea used for gout |
| CN104012729A (en) * | 2014-06-11 | 2014-09-03 | 杨平 | Tea substitute bag capable of lowering uric acid |
-
2014
- 2014-10-30 CN CN201410593469.0A patent/CN104366636B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036680A (en) * | 2007-04-08 | 2007-09-19 | 谢平 | Gynura procumbens troche and method for preparing the same |
| CN102366512A (en) * | 2011-09-04 | 2012-03-07 | 成都绿迪科技有限公司 | Traditional Chinese medicinal formula for treating gout |
| CN102908403A (en) * | 2012-11-13 | 2013-02-06 | 广东新大枫化工科技有限公司 | Chinese materia medica preparation for treating gout and preparation method thereof |
| KR101361846B1 (en) * | 2013-02-14 | 2014-02-13 | 강원대학교산학협력단 | Atural plant composition for modulate enzyme mrna relate to glucose metabolism in cell |
| CN103623099A (en) * | 2013-11-28 | 2014-03-12 | 王未境 | Sweet tea used for gout |
| CN104012729A (en) * | 2014-06-11 | 2014-09-03 | 杨平 | Tea substitute bag capable of lowering uric acid |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105876777A (en) * | 2016-04-12 | 2016-08-24 | 周安琪 | Food having effect of reducing uric acid and preparation technology thereof |
| CN105832794A (en) * | 2016-06-06 | 2016-08-10 | 江西本草天工科技有限责任公司 | Application of Gynura procumbens to production of medicine, healthcare food or functional food for preventing and treating hyperuricemia |
| CN106072560A (en) * | 2016-06-29 | 2016-11-09 | 傅志勇 | A kind of for health product treating gout and preparation method thereof |
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| CN107897441B (en) * | 2017-12-11 | 2021-03-30 | 江西省科学院应用化学研究所 | Gynura procumbens tea for relieving cough caused by smoking and preparation method thereof |
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| CN110772611A (en) * | 2019-12-13 | 2020-02-11 | 赵洪勇 | Traditional Chinese medicine composition for regulating gout |
| CN113244341A (en) * | 2021-07-06 | 2021-08-13 | 贵州百灵企业集团制药股份有限公司 | Medicine for treating kidney disease and preparation method thereof |
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| CN115350177A (en) * | 2022-08-23 | 2022-11-18 | 暨南大学 | Uric acid reducing function of extract and preparation method thereof |
| CN115350177B (en) * | 2022-08-23 | 2023-06-06 | 暨南大学 | Uric acid reducing function of extract and preparation method thereof |
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