CN109288967A - A kind of composition and preparation method thereof can promote traumatic wounds healing - Google Patents

A kind of composition and preparation method thereof can promote traumatic wounds healing Download PDF

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Publication number
CN109288967A
CN109288967A CN201811165987.7A CN201811165987A CN109288967A CN 109288967 A CN109288967 A CN 109288967A CN 201811165987 A CN201811165987 A CN 201811165987A CN 109288967 A CN109288967 A CN 109288967A
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parts
extract
composition
traumatic wounds
preparation
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吴学谦
吴思昊
杨胜祥
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Zhejiang A&F University ZAFU
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Zhejiang A&F University ZAFU
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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Abstract

The invention discloses a kind of compositions and preparation method thereof that can promote traumatic wounds healing, particularly belong to field of Chinese medicinal composition, based on parts by weight, the composition includes following component: 20~30 parts of radix tetrastigme, 10~20 parts of climbing groundsel, 5~10 parts of Radix Isatidis, 20~30 parts of roxburgh anoectochilus terminal bud, 10~15 parts of euphorbia fischeriana, 5~10 parts of chitosan, 3~7 parts of Fructus Forsythiae, 10~18 parts of honeysuckle, 5~10 parts of herba setariae viridis grass, 5~10 parts of frog clothing, 2~8 parts of peppermint, tealeaves 3~7,5~10 parts of semen momordicae, rose 8~16,3~7 parts of lemon, 8~15 parts of honey.The present invention has the advantages that promote wound healing and prevents traumatic wounds from being infected by germ.

Description

A kind of composition and preparation method thereof can promote traumatic wounds healing
Technical field
The invention belongs to field of Chinese medicinal composition, specially a kind of composition that can promote traumatic wounds healing and its preparation Method.
Background technique
Skin is the maximum organ of human body area, is body and extraneous mechanical barrier, various ulcer, wound or burnt degree Defect of skin is clinical common one of illness, these symptoms may cause a series of problems of body, such as bacterium infection, Moisture and protein are excessively lost.Studies have shown that skin wound healing is a complicated pathophysiological process, generally comprise Inflammatory phase, proliferation period and remodeling phase.In wound healing process, when especially damaging serious, continuous anoxic, necrosis, sense are organized The factors such as dye can all make the agglutination of wound extend, and healing is difficult.
Post-traumatic skin is easy the infection by germ, to cause the symptoms such as running sore or redness.Also, normal gauze Perhaps gauze or dressing are easy to bond together due to absorbing skin diffusate with skin when wound is wrapped up in dressing, To cause secondary insult during removing gauze or dressing in the later period.
Summary of the invention
The present invention provides a kind of composition and preparation method thereof that can promote traumatic wounds healing, the composition, which has, to be promoted The advantages of into wound healing and preventing traumatic wounds from being infected by germ.
To achieve the above object, the invention provides the following technical scheme:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves 20~30 parts green, 10~20 parts of climbing groundsel, 5~10 parts of Radix Isatidis, 20~30 parts of roxburgh anoectochilus terminal bud, 10~15 parts of euphorbia fischeriana, shell is poly- 5~10 parts of sugar, 3~7 parts of Fructus Forsythiae, 10~18 parts of honeysuckle, 5~10 parts of herba setariae viridis grass, 5~10 parts of frog clothing, 2~8 parts of peppermint, Tealeaves 3~7,5~10 parts of semen momordicae, rose 8~16,3~7 parts of lemon, 8~15 parts of honey.
Wherein, radix tetrastigme is known as the title of natural plants antibiotic, has clearing heat and detoxicating, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain etc. Effect, can inhibit the growth of wound site germ, to be more conducive to the reparation of wound.Climbing groundsel, Radix Isatidis, radix euphorbiae lantu are big Halberd, chitosan, Fructus Forsythiae and honeysuckle all have antibacterial disinfection, anti-infectious effect, meanwhile, the effective component of said herbal medicine After wound enters patient's body, it is greatly improved the immunocompetence of patient itself, promotes impaired skin tissue regeneration.And And herba setariae viridis grass, frog clothing, peppermint, tealeaves and semen momordicae have effects that swelling and pain relieving, can reduce patient because trauma draws The pain of hair.Rose, lemon and honey can supplement mineral element and vitamin appropriate for human body, can promote wound wound The wound healing of mouth, greatly shortens the time of healing.
The present invention is blended by said herbal medicine component according to preset proportion, and is sprayed at traumatic wounds, Wound can not only be prevented to be infected in agglutination, and can promote the self-regeneration of skin histology, to contract significantly The time of wound healing is subtracted.Due in said components, same components have the function of a variety of different, have between each component Synergistic effect, so that method provided by the present invention is in the better effect for promoting wound healing.
Preferably, the composition further includes at least one of Auricularia extract, Thallus Laminariae (Thallus Eckloniae) extract.Auricularia extract and Rich in trace quantity mineral substance elements such as sodium, zinc in Thallus Laminariae (Thallus Eckloniae) extract, after being absorbed by the body, the healing of wound can be effectively facilitated.
Preferably, the composition further includes at least one of peanut oil, walnut oil.
Preferably, the composition further includes at least one of tomato extract, apple extract.Tomato extract, It is rich in each biostearin in apple extract, can promote traumatic wounds and quickly heal.
Preferably, the composition further includes at least one of rice bran, kudzuvine root starch.Containing vitamin and on a small quantity in rice bran Mine trace element can promote the regeneration of skin histology.Kudzuvine root starch not only has fungistatic effect simultaneously, and ethanol solution is in colloid Shape can adhere at traumatic wounds, so that the effective component in Chinese herbal medicine not easily runs off.Also, the mixture of rice bran and kudzuvine root starch The soft-shell with hardness can be formed after solidification, protect traumatic wounds not by the invasion of alien bacteria, advantageously In the reparation of skin histology.
As further preferred, described composition, based on parts by weight, including following component: 25 parts of radix tetrastigme, a thousand li 15 parts of light, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, 14 parts of honeysuckle, dog tail 8 parts of grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, rose 12,5 parts of lemon, 9 parts of honey, Auricularia extract 6 Part, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil, 3 parts of kudzuvine root starch.
Preferably, the preparation method of Auricularia extract and Thallus Laminariae (Thallus Eckloniae) extract respectively includes following steps:
The preparation of Thallus Laminariae (Thallus Eckloniae) extract:
(1) clean kelp being placed in 60~80 DEG C of warm water, ultrasound 20~30min of extraction repeats extraction 3 times, Merge the filtrate obtained three times, revolving arrives Thallus Laminariae (Thallus Eckloniae) extract to dry.
The same step of the preparation method of Auricularia extract (1).
Preferably, the preparation method of tomato extract and apple extract respectively includes following steps:
The preparation of tomato extract
S01, it dices after cleaning tomato, is placed on 15~20min of extraction in 40~50 DEG C of tepidarium, filtrate is through macropore Resin adsorption removes depigmentaton, collects the filtrate that decoloration is completed, and revolving arrives tomato extract to dry.
The preparation method of apple extract is the same as step S01.
The present invention also provides the preparation method of above-mentioned composition, which includes the following steps:
A, it is dried after cleaning each component, accurately weighs each component by ratio of weight and the number of copies, processing of being milled after being uniformly mixed, Obtain hybrid solid powder；
B, the ethanol solution that enough mass fractions are 60~80%, ultrasound leaching are added in obtained hybrid solid powder After mentioning 40~60min, filtering obtains filtrate；
C, filtrate is rotated to medicinal extract shape, and is the second that 1:2 is added that mass fraction is 40% according to the mass ratio with medicinal extract Alcoholic solution redissolves, and obtains mixed solution；
D, emulsifier is added in mixed solution, obtains the composition that can promote traumatic wounds healing after mixing.
Preferably, emulsifier is polysorbas20 in step d.
The invention has the benefit that
The present invention is blended by said herbal medicine component according to preset proportion, and is sprayed at traumatic wounds, Wound can not only be prevented to be infected in agglutination, and can promote the self-regeneration of skin histology, to contract significantly The time of wound healing is subtracted.Due in said components, same components have the function of a variety of different, have between each component Synergistic effect, so that method provided by the present invention is in the better effect for promoting wound healing.
Specific embodiment
Embodiment 1
The present embodiment provides a kind of technical solutions:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 25 parts green, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, honeysuckle 14 parts, 8 parts of herba setariae viridis grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, rose 12,5 parts of lemon, 9 parts of honey, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil, 3 parts of kudzuvine root starch.
The preparation method of above-mentioned composition includes the following steps:
A, 25 parts of radix tetrastigme are taken, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, chitosan 7 Part, 5 parts of Fructus Forsythiae, 14 parts of honeysuckle, 8 parts of herba setariae viridis grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, rose 12, 5 parts of lemon clean after dry, accurately weigh each component by ratio of weight and the number of copies, milled processing after being uniformly mixed, obtain mixing and consolidate Body powder.
B, the ethanol solution that enough mass fractions are 70%, ultrasound extraction are added in obtained hybrid solid powder After 45min, filtering obtains filtrate.9 parts of honey of the addition in filtrate, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, peanut oil 3 Part, 2 parts of walnut oil, 3 parts of kudzuvine root starch, after mixing, obtain mixed liquor.
C, mixed liquor is rotated to medicinal extract shape, and according to the mass ratio with medicinal extract be 1:2 be added mass fraction be 40% Ethanol solution redissolves, and obtains mixed solution.
D, polysorbas20 is added in mixed solution, obtains the composition that can promote traumatic wounds healing after mixing.
Embodiment 2
The present embodiment provides a kind of technical solutions:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 20 parts green, 10 parts of climbing groundsel, 5 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 10 parts of euphorbia fischeriana, 5 parts of chitosan, 3 parts of Fructus Forsythiae, honeysuckle 10 parts, 5 parts of herba setariae viridis grass, 5 parts of frog clothing, 2 parts of peppermint, 3 parts of tealeaves, 5 parts of semen momordicae, 8 parts of rose, 3 parts of lemon, honey 8 Part, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil, 3 parts of kudzuvine root starch.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Embodiment 3
The present embodiment provides a kind of technical solutions:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 23 parts green, 16 parts of climbing groundsel, 7 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, honeysuckle 13 parts, 8 parts of herba setariae viridis grass, 7 parts of frog clothing, 6 parts of peppermint, 4 parts of tealeaves, 7 parts of semen momordicae, 14 parts of rose, 4 parts of lemon, honey 12 parts, 4 parts of Auricularia extract, 3 parts of Thallus Laminariae (Thallus Eckloniae) extract, 4 parts of peanut oil, 1 part of walnut oil, 2 parts of kudzuvine root starch.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Embodiment 4
The present embodiment provides a kind of technical solutions:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 30 parts green, 20 parts of climbing groundsel, 10 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 15 parts of euphorbia fischeriana, 10 parts of chitosan, 7 parts of Fructus Forsythiae, gold and silver Spend 18 parts, 10 parts of herba setariae viridis grass, 10 parts of frog clothing, 8 parts of peppermint, 7 parts of tealeaves, 10 parts of semen momordicae, 16 parts of rose, 7 parts of lemon, 15 parts of honey.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Comparative example 1
This comparative example provides a kind of technical solution:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: dog tail Bars 8 parts of grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, rose 12,5 parts of lemon, 9 parts of honey, Auricularia extract 6 parts, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil, 3 parts of kudzuvine root starch.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Comparative example 2
This comparative example provides a kind of technical solution:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 25 parts green, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, honeysuckle 14 parts, rose 12,5 parts of lemon, 9 parts of honey, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, walnut oil 2 Part, 3 parts of kudzuvine root starch.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Comparative example 3
This comparative example provides a kind of technical solution:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 25 parts green, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, honeysuckle 14 parts, 8 parts of herba setariae viridis grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, 3 parts of kudzuvine root starch.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Comparative example 4
This comparative example provides a kind of technical solution:
A kind of composition can promote traumatic wounds healing, based on parts by weight, the composition includes following component: three leaves It is 25 parts green, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, 13 parts of euphorbia fischeriana, 7 parts of chitosan, 5 parts of Fructus Forsythiae, honeysuckle 14 parts, 8 parts of herba setariae viridis grass, 8 parts of frog clothing, 5 parts of peppermint, tealeaves 5,8 parts of semen momordicae, rose 12,5 parts of lemon, 9 parts of honey, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil.
The preparation method is the same as that of Example 1 for above-mentioned composition.
Test case 1
This test case is for probing into composition provided by the invention to the therapeutic effect of the external wound of white rabbit.
Same batch is chosen, quality is in white rabbit 270 of 4~5 kilograms, is randomly divided into 9 groups, and number is A~I respectively. Composition provided by Examples 1 to 4, comparative example 1~4, each administration are smeared respectively in the traumatic wounds of A~H group white rabbit Dosage is 2 ± 0.1g, and twice a day, the time that is administered continuously is 15 days.The pure water of the quality such as I group white rabbit smearing does control experiment Processing.After 15 days, white rabbit traumatic wounds situation statistics such as the following table 1:
The external traumatic wounds situation statistical form of 1 white rabbit of table
Test case 2
On the basis of test case 1, this test case continues human experimentation.
The patient 90 for choosing wound at arm, is randomly divided into 9 groups, and number is a~i respectively.Wherein, in a~h group white rabbit Traumatic wounds successively smear Examples 1 to 4, composition provided by comparative example 1~4 respectively, and each dosage is 2 ± 0.1g, twice a day, the time that is administered continuously are 15 days.The pure water of the quality such as i group white rabbit smearing does control experiment processing.15 days Afterwards, white rabbit traumatic wounds situation statistics such as the following table 2:
The external traumatic wounds situation statistical form of 2 volunteer of table
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, It is still possible to modify the technical solutions described in the foregoing embodiments, or part of technical characteristic is carried out etc. With replacement, all within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in this Within the protection scope of invention.

Claims (10)

1. a kind of composition that can promote traumatic wounds healing, which is characterized in that based on parts by weight, including following component:
20~30 parts of radix tetrastigme, 10~20 parts of climbing groundsel, 5~10 parts of Radix Isatidis, 20~30 parts of roxburgh anoectochilus terminal bud, euphorbia fischeriana 10~15 Part, 5~10 parts of chitosan, 3~7 parts of Fructus Forsythiae, 10~18 parts of honeysuckle, 5~10 parts of herba setariae viridis grass, 5~10 parts of frog clothing, peppermint 2~8 parts, 3~7 parts of tealeaves, 5~10 parts of semen momordicae, 8~16 parts of rose, 3~7 parts of lemon, 8~15 parts of honey.
2. a kind of composition that can promote traumatic wounds healing according to claim 1, which is characterized in that further include agaric At least one of extract, Thallus Laminariae (Thallus Eckloniae) extract.
3. a kind of composition that can promote traumatic wounds healing according to claim 1, which is characterized in that further include peanut At least one of oil, walnut oil.
4. a kind of composition that can promote traumatic wounds healing according to claim 1, which is characterized in that further include tomato At least one of extract, apple extract.
5. a kind of composition that can promote traumatic wounds healing according to claim 1, which is characterized in that further include rice At least one of chaff, kudzuvine root starch.
6. any a kind of composition that can promote traumatic wounds healing according to claim 1~5, which is characterized in that with Parts by weight meter, including following component: 25 parts of radix tetrastigme, 15 parts of climbing groundsel, 8 parts of Radix Isatidis, 25 parts of roxburgh anoectochilus terminal bud, euphorbia fischeriana 13 Part, 7 parts of chitosan, 5 parts of Fructus Forsythiae, 14 parts of honeysuckle, 8 parts of herba setariae viridis grass, 8 parts of frog clothing, 5 parts of peppermint, 5 parts of tealeaves, semen momordicae 8 Part, rose 12,5 parts of lemon, 9 parts of honey, 6 parts of Auricularia extract, 2 parts of Thallus Laminariae (Thallus Eckloniae) extract, 3 parts of peanut oil, 2 parts of walnut oil, 3 parts of kudzuvine root starch.
7. a kind of composition that can promote traumatic wounds healing according to claim 2, which is characterized in that Auricularia extract Following steps are respectively included with the preparation method of Thallus Laminariae (Thallus Eckloniae) extract:
The preparation of Thallus Laminariae (Thallus Eckloniae) extract:
(1) clean kelp is placed in 60~80 DEG C of warm water, ultrasound 20~30min of extraction repeats extraction 3 times, merges The filtrate obtained three times, revolving arrive Thallus Laminariae (Thallus Eckloniae) extract to dry.
The same step of the preparation method of Auricularia extract (1).
8. a kind of composition that can promote traumatic wounds healing according to claim 4, which is characterized in that tomato extract Following steps are respectively included with the preparation method of apple extract:
The preparation of tomato extract
S01, it dices after cleaning tomato, is placed on 15~20min of extraction in 40~50 DEG C of tepidarium, filtrate is through macroreticular resin It is adsorbed and removed pigment, collects the filtrate that decoloration is completed, revolving arrives tomato extract to dry.
The preparation method of apple extract is the same as step S01.
9. the preparation method of composition according to claim 5, which comprises the steps of:
A, it is dried after cleaning each component, accurately weighs each component by ratio of weight and the number of copies, processing of being milled after being uniformly mixed obtains Hybrid solid powder；
B, the ethanol solution that enough mass fractions are 60~80%, ultrasound extraction 40 are added in obtained hybrid solid powder After~60min, filtering obtains filtrate；
C, filtrate is rotated to medicinal extract shape, and is that the ethyl alcohol that 1:2 addition mass fraction is 40% is molten according to the mass ratio with medicinal extract Liquid redissolves, and obtains mixed solution；
D, emulsifier is added in mixed solution, obtains the composition that can promote traumatic wounds healing after mixing.
10. the preparation method of composition according to claim 9, which is characterized in that in step d, emulsifier is polysorbas20.
CN201811165987.7A 2018-10-08 2018-10-08 A kind of composition and preparation method thereof can promote traumatic wounds healing Pending CN109288967A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793840A (en) * 2019-03-13 2019-05-24 浙江理工大学 Radix tetrastigme wound healing promoting cream and preparation method thereof
CN112451547A (en) * 2020-12-31 2021-03-09 中国海洋大学 Method for preparing scald ointment by using marine fish leftovers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103006923A (en) * 2012-12-26 2013-04-03 杨桂香 Chinese medicinal liquid band-aid and preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103006923A (en) * 2012-12-26 2013-04-03 杨桂香 Chinese medicinal liquid band-aid and preparation method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793840A (en) * 2019-03-13 2019-05-24 浙江理工大学 Radix tetrastigme wound healing promoting cream and preparation method thereof
CN112451547A (en) * 2020-12-31 2021-03-09 中国海洋大学 Method for preparing scald ointment by using marine fish leftovers
CN112451547B (en) * 2020-12-31 2023-05-05 中国海洋大学 Method for preparing scald ointment by using sea fish offal

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Application publication date: 20190201