CN1122521C - Coptis liquid for relieving inflammation and moistening skin and its preparing process - Google Patents
Coptis liquid for relieving inflammation and moistening skin and its preparing process Download PDFInfo
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- CN1122521C CN1122521C CN 00131118 CN00131118A CN1122521C CN 1122521 C CN1122521 C CN 1122521C CN 00131118 CN00131118 CN 00131118 CN 00131118 A CN00131118 A CN 00131118A CN 1122521 C CN1122521 C CN 1122521C
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Abstract
The present invention discloses new medicine for preventing the infection of an incision wound. Coptis, phellodendron bark, baical skullcap root, garden burnet root, giant knotweed rhizome, radix glycyrrhiza, honeysuckle stem, borneol and ethanol are used as raw materials, the raw materials are proportionally prepared and ripened after the pretreatment of a cutting-off process, a pulverizing process, etc., according to different characteristics of traditional Chinese medicine, and then an aqueous agent is obtained by sterilization. The present invention has the advantages of unique prescription and manufacturing method and significant treating effect.
Description
The present invention relates to a kind of medicament of antiinflammatory skin moistening, specifically it is to be the Chinese patent medicine mixture of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
The existing preventive preparation that is used for infection of incisional wound there is no special-purpose medicine.Its clinical practice Western medicine is used metronidazole always, or metronidazole and gentamycin flushing otch, makes every effort to reach the purpose of prevention infection of incisional wound.Also useful Chinese medicine yinhua mixture areosol or preparations such as Mel, rifampicin gauze are applied in clinical after the infection of incisional wound, also have in otch built-in " Pan Shi pipe ", or the experimentation of preventing infection of incisional wound as antibiotic such as gentamycin " sequential therapy ", but the effective percentage of its prevention infection of incisional wound is lower.Particularly, basic hospital three class incision infection rates are higher, and patient's medical expense height, patient's misery is bigger, treatment cycle is long.Cicatrix does not dwindle basically, and the cicatrix surface irregularity.
The object of the present invention is to provide a kind of partial antiinflammatory of reinforcement that has, microcirculation improvement is eliminated hemorrhage (hematocele) in the otch, promotes the healing of otch (damage), and the wound pain is removed in skin care, strengthens the medicament of patient's body constitution and body's immunity.Particularly at the Rhizoma Coptidis antiinflammatory skin lotion that has unique effects aspect prevention and the treatment infection of incisional wound.
Another object of the present invention provides the preparation method of this Rhizoma Coptidis antiinflammatory skin lotion.
Solution of the present invention is based on motherland's medical science to infection of incisional wound and pathogenetic understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medical treasure-house, filter out heat-clearing and toxic substances removing (antiinflammatory), blood circulation promoting and blood stasis dispelling, activating collaterals and eliminating stagnation, reducing swelling and alleviating pain, the body resistance strengthening and constitution consolidating, the homologous natural edible-plant medicine of medicated diet.By the theory of Chinese medical science prescription, skim the cream off milk, it is reached eliminate otch inflammation on every side, improve otch blood circulation on every side, promote the absorption of hematocele in the otch, promote new epithelial growth, quicken the healing of otch, avoid and prevent the effect of infection of incisional wound.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Rhizoma Coptidis 60-120 Cortex Phellodendri 60-120 Radix Scutellariae 35-95
Radix Sanguisorbae 20-80 Rhizoma Polygoni Cuspidati 35-95 Radix Glycyrrhizae 25-55
Caulis Lonicerae 25-55 Borneolum Syntheticum 5-25 ethanol 50-100
Weight (part) ratio range of the formula optimization of preparation medicine of the present invention is:
Rhizoma Coptidis 80-100 Cortex Phellodendri 80-100 Radix Scutellariae 50-80
Radix Sanguisorbae 40-70 Rhizoma Polygoni Cuspidati 55-80 Radix Glycyrrhizae 40-50
Caulis Lonicerae 30-50 Borneolum Syntheticum 10-20 ethanol 70-90
The optimum weight of medicine of the present invention (part) proportioning is:
Rhizoma Coptidis 100 Cortex Phellodendris 100 Radix Scutellariaes 75
Radix Sanguisorbae 60 Rhizoma Polygoni Cuspidati 75 Radix Glycyrrhizaes 45
Caulis Lonicerae 45 Borneolum Syntheticums 15 ethanol 75
Above-mentioned each component is made medicine production method of the present invention is:
1, earlier Borneolum Syntheticum is ground into fine powder, the section sheet that is cut into 5-7cm is cleaned, dried to Caulis Lonicerae.
2, get Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae and be ground into coarse powder respectively.
3, the coarse powder of getting Caulis Lonicerae and Radix Scutellariae, Radix Glycyrrhizae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati four Chinese medicine decocts with water three times, each 60-120 minute, add Borneolum Syntheticum fine powder and Rhizoma Coptidis, the coarse powder of Cortex Phellodendri again, continuous frying in shallow oil 10-30 minute, collecting decoction is cooled to 5 ℃-30 ℃, add 70-95% ethanol again, filter, collect filtrate, discard residue and add an amount of antiseptic again, shake up.
4, above-mentioned whole filtrates are packed in the different bottle of specification, sealed,, carry out, sterilization treatment 10-30 minute, can be prevented or treat the Rhizoma Coptidis antiinflammatory skin lotion of infection of incisional wound at 100-115 ℃.
The disinfecting action here is to adopt step type cooling ripening sterilization, and temperature is raised to 115 ℃ rapidly, and segmentation is reduced to 100 ℃ then, sterilization time is 30 minutes, be mixed liquor 115 ℃ of insulations 10 minutes down, and then cool to 105 ℃ and kept 10 minutes, be cooled to 100 ℃ again and kept 10 minutes.
An important feature of the present invention is to contain abundant nutrition such as protein and each seed amino acid etc. in the medicament, also contains various trace elements such as potassium, magnesium, calcium, zinc, ferrum in addition in therapeutic agent of the present invention.These aminoacid and various trace elements can absorb by capillary of skin and enter blood circulation, thus the body constitution of enhancing body.
Another important feature of the present invention is to contain materials such as abundant berberine, phellodendrine, the gentle matter of grass, Radix Sanguisorbae soap, glycyrrhizin, corticoid in the medicament.Can strengthen leukocytic phagocytic function, especially extremely strong to the effect of antibacterials such as golden Portugal bacterium, bacillus enteritidis, enterococcus, bacillus pyocyaneus, Candida albicans, Bacillus typhi, dysentery bacterium, has the broad-spectrum antiseptic antiinflammation, can directly strengthen the resistance against diseases of local skin, and the absorption of hemorrhage (hydrops) and reducing swelling and alleviating pain in the promotion otch, promote new epithelial growth, reduce infective agent, the discomfort or the untoward reaction of antipruritic, pain relieving, releasing postoperative wound.Promote wound healing.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the homologous natural edible-plant medicine of medicated diet for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment or the prevention infection of incisional wound of the Chinese medicine of respectively distinguishing the flavor of, do not have chemical sweeting agent, powerless antagonism and incompatibility, nontoxic, side effect and untoward reaction.
2, changed the shortcoming of the unformed medicament of existing infection of incisional wound, compared with Western medicine prevention infection of incisional wound: reduced the infection of incisional wound rate, reduced patient's the medical time, saved medical expense, and reduced patient's misery.
For showing prevention or the therapeutic effect of medicament of the present invention to infection of incisional wound, with simple appendicitis, suppuration appendicitis, this three classes infection of incisional wound of gangrene (perforation) property appendicitis on former treatment basis, the Western medicine antiinflammatory of stopping using, local topical medicament of the present invention.Through 208 routine case clinical observations.Wherein male 116 examples, women 92 examples; Age 5-79 year, average 42 years old; Simple appendicitis 44 examples (accounting for 21.16%), suppurative appendicitis 81 examples (accounting for 38.94%), gangrene (perforation) property appendicitis 83 examples (accounting for 39.90%). matched group 198 examples: adopt metronidazole and gentamycin flushing otch, wherein: simple appendicitis 82 examples (accounting for 41.42%), suppurative appendicitis 60 examples (accounting for 30.3%), gangrenous appendicitis 56 examples account for (28.28%). and the anti-inflammatory treatment method is identical routinely for two groups of postoperatives.
Usage, consumption: drench this medicinal liquid 10-20ml4-6 time/day on the otch dressing for skin, postoperative three days more change dressings is once used and is drenched medicinal liquid with quadrat method and take out stitches until otch and afterwards got final product in 2-3 days.Be generally the course of treatment 7-10 days.
Observational technique: observe feeling of patient, wound has or not the pain sense of discomfort, and wound how are you feeling today before and after the medication has or not comfort or pain sense of discomfort to disappear, and pushing wound has painlessly, checks that wound has or not red, swollen, hot, phenomenon and hemorrhage phenomenon bitterly.
Criterion of therapeutical effect:
1, produce effects: the healing of otch first class, around reaching, otch do not have red, swollen, hot, pain performance, no secretions, cicatrix is little, smooth, pushes no any discomfort sense.
2, effective: the healing of otch first class, otch and around red, heat and sense of discomfort are arranged.
3, invalid: otch second-third class healing, red, swollen, hot, performance bitterly that otch has, otch has abscess, hydrops or hematoma, and the piece of infiltration or hematoma are arranged, and has the piece of infiltration or suture pinprick that secretions is arranged, and otch suppurates and need open wide drain person by row.
Appendicitis belongs to motherland's medical science " acute appendicitis " category, by pyretic toxicity institute extremely, although after the appendicitis excision, still have pyretic toxicity to be stored in the body, so, use Rhizoma Coptidis antiinflammatory skin lotion external application otch skin, just for poison after removing in the body, and by the poison, the heat that are forming due to the damage (mechanicalness and bacillary).
Table 1 liang group three class wound healings and infection are relatively
Treatment group matched group example number first (%) second (%) infects routine number first (%) second (%) third (%) sense
Rate % dyes rate % pure 44 44 100.00 000 82 72 87.80 10 12.20 00 12.20 suppurative 81 81 100.00 000 60 40 66.67 18 30.00 2 3.33 33.33 gangrene 83 80 100.00 33 3.6 56 28 50.00 20 35.71 8 14.29 50.00 and adds up to 208 205 98.56 33 1.44 198 140 70.71 48 24.24 10 5.05 29.29 (1) x2=5.83, p＜0.01 (2) x
2=31.46, p＜0.01 (3) x
2=41.52, p＜0.01 (4) x
2=71.07, p＜0.01
By table 1 as seen: treatment group and each ranks of matched group more variant, the first class healing prevention total effective rate of treatment group and matched group otch is 98.56%＞70.71%, learns by statistics and handles x
2=71.07, (p＜0.01), the infection of incisional wound rate is 1.44%＜29.29%, t=8.34, and there is the utmost point significance meaning bilateral p＜0.01.
Table 2 liang group prevention three class infection of incisional wound total effective rates are relatively. and the routine digital display that divides into groups is imitated number significant figure invalid number total effective rate % obvious effective rate % treatment group n=208 184 21 3 98.56 88.56 matched group n=198 114 26 58 70.71 57.58
Two groups of obvious effective rates are 88.46%＞57.88%, and t=7.39 (p＜0.01) has utmost point significance meaning.
Table 3 liang group appendicitis patient's length of stay compares: the longest number of days of routine number total bed number of days the shortest number of days of average time in hospital day divides into groups
X treatment group n=208 1,624 74 10 matched group n=198 3,632 18 10 26
Table 4 a liang group appendicitis patient is in hospital mean and expense relatively: (the routine number X ± S of grouping of X ± S) (my god) X ± S (unit) treatment group n=208 7.0 ± 2.15 850.0 ± 212.33 matched group n=198 18.0 ± 4.25 1390 ± 443.14
Two groups of appendicitis patients difference in means t=31.39 (P＜0.01) that is in hospital, its medical expense relatively t=15.77 (P＜0.01) all has utmost point significance meaning.
The drain situation of two groups of appendicitis operative incisions relatively, after the treatment group self-application Rhizoma Coptidis antiinflammatory skin lotion, when operation, all do not carry out drain, its infection of incisional wound prevention effective percentage reaches 98.56%, and in matched group 198 examples, 40 examples (gangrene 28 examples is arranged, suppurative 12 examples) all used the method for cigarette drain, consequently infection of incisional wound rate still has 29.29%.Statement of facts; Used Rhizoma Coptidis antiinflammatory skin lotion person and do not used this medicinal liquid person, aspect the healing of otch and the infection evident difference and utmost point significance meaning have been arranged.
The suitability of this medicament is strong, and is of many uses, except the prevention that is applied to all kinds of infections of incisional wound, also can be applicable to damage, vasculitis, skin ulcer, oral ulcer, the acute and chronic otitis media of slight burn, various skin, soft tissue; Various dermatosiss, skin infection etc.Particularly the first class healing rate to the mastocarcinoma otch is 100%, and healing time is 7-10 days 28-58 days less than existing additive method, and (p＜0.01) has significant clinical practice meaning.
Embodiment:
Take by weighing raw material by following proportioning:
Rhizoma Coptidis 100g Cortex Phellodendri 100g Radix Scutellariae 75g
Radix Sanguisorbae 60g Rhizoma Polygoni Cuspidati 75g Radix Glycyrrhizae 45g
Caulis Lonicerae 45g Borneolum Syntheticum 15g 95% ethanol 75ml
Production method is as follows:
Borneolum Syntheticum is ground into fine powder, Caulis Lonicerae (is cleaned, dry) be cut into 5-7cm the section sheet, with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Sanguisorbae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati Six-element medicine is ground into coarse powder respectively, earlier with Caulis Lonicerae and Radix Scutellariae, Radix Glycyrrhizae, Radix Sanguisorbae, the coarse powder of Rhizoma Polygoni Cuspidati four Chinese medicine adds decocting three times, each 105 minutes, add Borneolum Syntheticum fine powder and Rhizoma Coptidis again, the coarse powder of Cortex Phellodendri, continuous frying in shallow oil 15 minutes (amounting to two hours), collecting decoction is put coldly, adds 95% ethanol again and shakes up, leave standstill, filter, collect filtrate, adding an amount of antiseptic again shakes up, finished product is packed in the bottle of various different sizes, adds a cover, and carries out 100 ℃ of sterilization treatment insulation 15 minutes.
Claims (7)
1, the medicament of treatment infection of incisional wound, it is a kind of be characterised in that it be by as the medicament made of following weight (part) proportion raw material.
Rhizoma Coptidis 60-120 Cortex Phellodendri 60-120 Radix Scutellariae 35-95
Radix Sanguisorbae 20-80 Rhizoma Polygoni Cuspidati 35-95 Radix Glycyrrhizae 25-55
Caulis Lonicerae 25-55 Borneolum Syntheticum 5-25 ethanol 50-100
2, the medicament of treatment wound according to claim 1 infection of incisional wound, wherein the weight proportion of each raw material is: Rhizoma Coptidis 80-100 Cortex Phellodendri 80-100 Radix Scutellariae 50-80
Radix Sanguisorbae 40-70 Rhizoma Polygoni Cuspidati 55-80 Radix Glycyrrhizae 40-50
Caulis Lonicerae 30-50 Borneolum Syntheticum 10-20 ethanol 70-90
3, the medicament of treatment infection of incisional wound according to claim 1, wherein the weight of each raw material (part) proportioning is:
Rhizoma Coptidis 100 Cortex Phellodendris 100 Radix Scutellariaes 75
Radix Sanguisorbae 60 Rhizoma Polygoni Cuspidati 75 Radix Glycyrrhizaes 45
Caulis Lonicerae 45 Borneolum Syntheticums 15 ethanol 75
4,, it is characterized in that described medicament is a water preparation according to the medicament of claim 1,2 or 3 described treatment infections of incisional wound.
5, the medicaments preparation method of treatment infection of incisional wound according to claim 4, it is characterized in that earlier Borneolum Syntheticum being ground into fine powder, Caulis Lonicerae is cleaned, dry the section sheet that is cut into 5-7cm, get Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae is ground into coarse powder respectively, with Caulis Lonicerae and Radix Scutellariae, Radix Glycyrrhizae, Radix Sanguisorbae, the coarse powder of Rhizoma Polygoni Cuspidati four Chinese medicine decocts with water three times, each 60-120 minute, add Borneolum Syntheticum fine powder and Rhizoma Coptidis again, the coarse powder of Cortex Phellodendri, continuous frying in shallow oil 10-30 minute, collecting decoction, cooling adds ethanol 50-100ml again, filters, collect liquid, under 100 ℃ of-115 ℃ of temperature sterilization treatment 10-30 minute, make.
6, the medicaments preparation method of treatment wound according to claim 5 infection of incisional wound, disinfecting action wherein are to adopt the anti-ladder type cooling of segmentation sterilization, and rapidly to 115 ℃, to reduce to 100 ℃ of sterilization times be 10-30 minute in segmentation then temperature.
7, the medicaments preparation method of treatment wound according to claim 6 infection of incisional wound, wherein disinfecting action be with mixed liquor 115 ℃ of down insulations 10 minutes, and then cool to 105 ℃ and kept 10 minutes, be cooled to 100 ℃ again and kept 10 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131118 CN1122521C (en) | 2000-11-06 | 2000-11-06 | Coptis liquid for relieving inflammation and moistening skin and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131118 CN1122521C (en) | 2000-11-06 | 2000-11-06 | Coptis liquid for relieving inflammation and moistening skin and its preparing process |
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| Publication Number | Publication Date |
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| CN1293968A CN1293968A (en) | 2001-05-09 |
| CN1122521C true CN1122521C (en) | 2003-10-01 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100367971C (en) * | 2006-04-06 | 2008-02-13 | 山西大学 | Baicalin dropping pill and its preparing method |
| CN101129557B (en) * | 2007-07-31 | 2010-04-14 | 雷超清 | Traditional Chinese medicine for treating bacterial infection |
| CN103768277B (en) * | 2012-10-19 | 2017-09-05 | 孝昌县第一人民医院 | A kind of clinical medicine compounding method for treating burn wound |
| CN103285118B (en) * | 2013-05-13 | 2015-04-15 | 张强 | Snake oil burn cream |
| CN104257787A (en) * | 2014-10-27 | 2015-01-07 | 青岛大学附属医院 | Traditional Chinese medicine composition for treating oral ulcer |
| CN109464549A (en) * | 2018-10-16 | 2019-03-15 | 谭国川 | A kind of paste and production method for treating skin trauma and infection |
| CN114344379A (en) * | 2022-01-19 | 2022-04-15 | 陈林 | Herbal medicine formula for treating general ulceration and application thereof |
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