CN1025109C - Process for preparing injection of bitter cassia holo-element - Google Patents
Process for preparing injection of bitter cassia holo-element Download PDFInfo
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- CN1025109C CN1025109C CN 90107984 CN90107984A CN1025109C CN 1025109 C CN1025109 C CN 1025109C CN 90107984 CN90107984 CN 90107984 CN 90107984 A CN90107984 A CN 90107984A CN 1025109 C CN1025109 C CN 1025109C
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- injection
- medicinal liquid
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- radix sophorae
- sophorae flavescentis
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Abstract
The present invention provides a method for preparing a Chinese herbal medicine injection for resisting cancer and stopping cancer pain. The present invention has the technological characteristics that lightyellow sophora roots and cassia barks are used as raw materials; then, the raw materials are repeatedly boiled and frozen, and are repeatedly purified and filtered with alcohol, acid and alkali to obtain the Chinese herbal medicine injection. Through clinical observation, the injection prepared by the method has the function of resisting cancer, and particularly, the injection has obvious effect of stopping cancer pain. The injection has the advantages of no toxicity and no side effect, and is suitable for various cancer patients.
Description
The present invention relates to the method that effective component extracting is made anticancer injection from plant (Chinese herbal medicine).
Cancer is a kind of pilosity on the our times, is difficult to the disease of capturing again.Prior treatment method all can not be effected a radical cure as operation, chemotherapy, diathermy etc., and the medicine of existing various curing oncomas, cancer all has the part curative effect, but can not effect a radical cure; Some medicine also has very big side effect.And, almost do not have specific treatment way for the pain that cancer produces.The Bleomycin A5 hydrochloride. (Western medicine injection) that Hebei Pharmaceutical Factory, Tianjin City produces just has side effect such as heating, gastrointestinal reaction, alopecia, acroanesthesia, lung toxic reaction.The cisplatin (Western medicine, injection) that brocade continent pharmaceutical factory produces also has the untoward reaction of gastrointestinal, hemogram, and the disadvantage of injury of kidney is arranged, and the using dosage discomfort has been quickened the deterioration of cancer from another channel.More than two kinds of some antitumaous effects of medicine, but all do not have the only effect of cancer pain.The Tianxian Capsule (oral medicine of medicinal herb components) that Changbai Mountain pharmaceutical factory produces has certain effect to ending cancer pain, but not obvious, can't use for being difficult for oral cancer patient (digestive disease).Under cancer patient pain situation unbearably, mainly be to sting and the morphine pain relieving with Du Leng.But these two kinds of medicines all are drugs, and the pain management time is short, uses strong toxicity continuously.
Now, the manufacture method of herbal injection mainly contains water seaoning, the way of distillation, solvent system extraction method etc.Water seaoning can only be extracted the part effective ingredient; The way of distillation can only extract volatile oil in the medicine and volatile ingredient, and other extracts active ingredients of many Chinese herbal medicine is not come out; Influence the therapeutic effect of medicine, the solvent system extraction method can be extracted the middle pharmaceutically active ingredient that is dissolved in each solvent, but used solvent the more, operation is just more complicated, step is longer, and the jammer that produces between each solvent can just the more should not be made in industrial work.
Task of the present invention provides a kind ofly to be had anti-cancer function and controls the cancer pain effect significantly and the preparation method of avirulence, the herbal injection that has no side effect.
For solving above-mentioned task, the Chinese herbal medicine that injection provided by the invention adopted is Radix Sophorae Flavescentis and Cortex Cinnamomi, and its manufacture method adopts to boil freezes alcohol and analyse the soda acid method of purification.The main technique flow process is: 1. clean Radix Sophorae Flavescentis and Cortex Cinnamomi are cut into pieces respectively, and be divided into 9～15: 1 ratio, 2. respectively a kind of dilute acid soln such as major-minor medicinal hydrochloric acid, acetic acid soaked, boil and boil, extract decocting liquid, be boiled into pasty state; 3. the ethanol that adds the same weight of mass, cold preservation in temperature-1～0 ℃; 4. with medical filtration after the cold preservation, and add a kind of dilute alkaline soln adjust pHs such as sodium hydroxide, potassium hydroxide; 5. above-mentioned operation is carried out repeatedly twice back and propose ethanol; 6. major-minor medicinal liquid is mixed reheat, filtration, adjust pH to 8.0～8.5; 7. the soil temperature 80 that adds former pharmaceutical quantities 1% is carried out fine straining again, obtains the finished product medicinal liquid; 8. bottle at last, seal, sterilize, pack.
Major-minor medicine Radix Sophorae Flavescentis of the present invention and cinnamomic ratio are 11～13: 1, and its effect is better.
The used dilute acid soln glacial acetic acid solution of 1% concentration preferably in acidization, used dilute alkaline soln 25～28% sodium hydroxide solution preferably in the alkalization process.
The effect why injection of the present invention's preparation can reach anticancer, end cancer pain, its mechanism at first is that the main and auxiliary medicine Radix Sophorae Flavescentis and the Cortex Cinnamomi of being adopted contain the curing oncoma composition.Explain according to book on Chinese herbal medicine: " Radix Sophorae Flavescentis cures mainly stagnation of QI in chest and abdomen, lump in the abdomen, remove mediocre swollen, settling five organs, flat gastric qi, treat malignant boil; The contained volatile oil of Cortex Cinnamomi has the abirritate effect, gets rid of the digestive tract pneumatosis, relaxes the digestive tract spasmic pain.The present invention with the warm nature of Cortex Cinnamomi, help kidney yang, get rid of the cold deficiency of principal agent, Cortex Cinnamomi also has a surname to lead the effect of hundred medicines simultaneously, so utilize its a surname to lead the through sick institute of principal agent, the help principal agent improves curative effect.
Secondly, manufacture method of the present invention is compared with other preparation method of existing Chinese medicine, its obvious improvement is: adopting boils repeatedly boils, freezing repeatedly, pure, sour, alkali is purification repeatedly, drawn the advantage of water extraction and solvent extraction method, various effective ingredient in the Chinese herbal medicine fully can be extracted, reach therapeutic effect.
Embodiment one:
Radix Sophorae Flavescentis and Cortex Cinnamomi are cleaned up in the enamel service sink with the room temperature tap water, place chamber ventilation airing to the water content of drying in the shade to be no more than 5%, the reuse microtome cuts into pieces (thickness is 0.5-0.6mm), and getting Radix Sophorae Flavescentis and cinnamomic weight ratio is 12: 1, takes following technological process then;
(1) with the glacial acetic acid (CH of 1% concentration
3COOH, 99.0% analytical pure) mix by weight 4: 1 of solution and Radix Sophorae Flavescentis fragment, boils to boil in the still at enamel and boil 30 minutes, takes out decocting liquid.Medicinal residues boil by carrying out boiling the second time with quadrat method for the first time.Again medicinal residues are boiled by 1: 2 adding distil water for the third time with former pharmaceutical quantities and boil 30 minutes.
(2) three decocting liquids are mixed, carry out coarse filtration with filter;
(3) filtrate is boiled in the still at enamel heat, be concentrated into pasty state;
(4) by weight 1: 1 of mass is added 95% medical ethanol;
(5) will add (1～0 ℃) cold preservation 24 hours in fridge of alcoholic acid medicinal liquid.
(6) medicinal liquid of cold preservation is taken out from fridge filter immediately, obtain the alkyd medicinal liquid;
(7) sodium hydroxide solution with 25～28% concentration is 9.0 with above-mentioned medicinal liquid adjust pH;
(8) by weight 1: 1 95% medical ethanol and above-mentioned medicinal liquid be blended in-1～0 ℃ of following cold preservation 24 hours;
(9) medicinal liquid after the cold preservation is obtained alkali alcohol medicinal liquid through filter paper filtering;
(10) extract ethanol with above-mentioned medicinal liquid distillation, and with heat exchanger, obtain containing the alkali medicinal liquid;
(11) the above-mentioned alkali medicinal liquid that contains is added glacial acetic acid (the same technical standard) adjust pH to 5.0;
(12) contain sour medicinal liquid and be heated to boiling point above-mentioned;
(13) filter;
(14) the Cortex Cinnamomi medicinal liquid is made by above-mentioned technological process fully, and main and auxiliary medicinal liquid is mixed;
(15) mixed medicinal liquid is heated to boiling point, filters again;
(16) above-mentioned medicinal liquid is added the NaoH solution adjust pH to 8.5 of 25%～28% concentration, be clear and bright liquid;
(17) add the soil temperature 80 of former medicament weight 1%;
(18) filter with filter bulb, get the finished product medicinal liquid;
(19) with bottling machine with pack into peace bottle of finished product medicinal liquid;
(20) the peace bottle closure of medicinal liquid will be housed with sealing machine;
(21) carry out sterilization treatment;
(22) pack.
The injection of pressing above-mentioned example manufacturing has anti-cancer function through clinical trial, and it is particularly evident that it ends the cancer pain effect, inject pain relief in back 20 minutes, inject after 20 injections no longer pain, according to 367 routine various cancer patients' treatments, analgesic anticarcinogen 366 examples that take effect, rate 99.1% takes effect, good to 124 routine analgesic effects in the 125 example pain property cancers, account for 99.2%, produce effects 117 examples, obvious effective rate 93.6%, an invalid example.This medicine does not have any toxic reaction, side effect such as no leukopenia, alopecia, spontaneous perspiration.In addition, this medicine also has differentiates it is cancer whether effect, and for the pain that is not cancer, this medicine does not then have analgesic effect.
Embodiment two:
Getting Radix Sophorae Flavescentis and Cortex Cinnamomi weight ratio is 9: 1, carries out acidify, simplifies processing with the hydrochloric acid solution and the potassium hydroxide solution of 0.6% concentration, and other technological procedure is identical with example one, and its medicine meets specification requirement.The clinic trial observing effect is satisfied, but the individual patient medication has fidgety sense slightly.
Embodiment three:
Get Radix Sophorae Flavescentis and the Cortex Cinnamomi weight ratio is 15: 1, press the medicine that the technological procedure of embodiment one is made, meet specification requirement.Clinic trial is observed, and it is also satisfied to end cancer pain and anticancer effect, and the patient does not have fidgety, but individual patient has the asthenia phenomenon.
Claims (3)
1, the manufacture method of a kind of hardship, injection of bitter cassia holo-element is characterized in that:
(1) get clean Radix Sophorae Flavescentis that cuts into pieces and Cortex Cinnamomi, its ratio is 9～15: 1;
(2) Radix Sophorae Flavescentis soaked, boils and boil, get it and be fried boiling in 4: 1 by weight with the glacial acetic acid solution of 1% concentration, so repeat twice, the medicinal residues adding distil water is boiled boil again, get its decocting liquid;
(3) decocting liquid with three acquisitions mixes, and filters, and with the filtrate heating, is concentrated into pasty state;
(4) by weight 1: 1 of mass is added ethanol, cold preservation 24 hours in-1～0 ℃ of temperature then;
(5) with the medical filtration after the cold preservation, the solution adjust pH that adds dilute alkali is 9.0;
(6) added ethanol by 1: 1 for the second time, then by above-mentioned condition cold preservation, filtration;
(7) extract ethanol;
(8) add acid solution adjust pH to 5.0 for the second time;
(9) above-mentioned acid-containing solution is heated to boiling point, filtration;
(10) be 5.0 Cortex Cinnamomi medicinal liquid with there being method obtain pH value equally;
(11) major-minor medicinal liquid is mixed, heat to boiling point, filtration;
(12) the solution adjust pH that adds dilute alkali is 8.0～8.5, is clear and bright liquid;
(13) add the soil temperature 80 of former pharmaceutical quantities 1%;
(14) obtain the finished product medicinal liquid behind the fine straining;
(15) bottle at last, seal, sterilize, pack.
2, the manufacture method of hardship according to claim 1, the complete plain injection in osmanthus is characterized in that: Radix Sophorae Flavescentis is 11～13: 1 with cinnamomic ratio.
3, the manufacture method of hardship according to claim 1 and 2, injection of bitter cassia holo-element is characterized in that added dilute alkaline soln is the sodium hydroxide solution of 25～28% concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90107984 CN1025109C (en) | 1990-09-19 | 1990-09-19 | Process for preparing injection of bitter cassia holo-element |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90107984 CN1025109C (en) | 1990-09-19 | 1990-09-19 | Process for preparing injection of bitter cassia holo-element |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1050326A CN1050326A (en) | 1991-04-03 |
| CN1025109C true CN1025109C (en) | 1994-06-22 |
Family
ID=4880790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90107984 Expired - Fee Related CN1025109C (en) | 1990-09-19 | 1990-09-19 | Process for preparing injection of bitter cassia holo-element |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1025109C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062181C (en) * | 1997-07-16 | 2001-02-21 | 山西金晶药业有限公司 | Compound sophora flavescens injection |
-
1990
- 1990-09-19 CN CN 90107984 patent/CN1025109C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1050326A (en) | 1991-04-03 |
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Address after: 047105 Su Zhen, Changzhi County, Shanxi Applicant after: Great-Wall Machinery Factory, Changzhi City Address before: 046000 No. 110 South Yanan Road, Shanxi, Changzhi Applicant before: Great-Wall Machinery Factory, Changzhi City |
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Free format text: CORRECT: APPLICANT; FROM: GREAT-WALL MACHINERY FACTORY, CHANGZHI CITY TO: FOUNDRY, CHANGZHI COUNTY, SHANXI PROVINCE |
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