KR100609643B1 - Herbal medicine composition for the treatment of dermatitis and a method of manufacturing the same - Google Patents

Abstract

The present invention relates to a herbal composition for treating dermatitis, and a method of manufacturing the same, and specifically to dermatitis including atopic dermatitis, including extracts of mugwort, snakeberry, evening primrose, willow, elm and tangerine, and egg yolk oil (egg yolk oil). It relates to a herbal composition having excellent efficacy and a method for producing the same.

The herbal composition of the present invention enables the development of a therapeutic drug without the side effects while being able to fundamentally treat the dermatitis including atopic dermatitis, which is rapidly increasing and difficult to treat in recent years, and also the majority of inevitable environmental pollution including the sick house syndrome. It enables the development of health food and cosmetic additives that allow modern people to prevent or alleviate the occurrence of dermatitis, including atopic dermatitis.

Dermatitis, atopy, mugwort, snakeberry, evening primrose, willow, elm, tanza, egg                  

Description

A herb medicine composite for treating dermatitis and a manufacturing process of it}

The present invention relates to a herbal composition capable of treating dermatitis, including atopic dermatitis, and a method of manufacturing the same.

Dermatitis (dermatitis) is a disease that causes inflammation of the skin, commonly used in the same sense as eczema (濕疹, eczema). Eczema (eczema) is an allergic disease of the skin caused by the addition of mechanical, physical and chemical stimuli from the outside to eczema stimulation such as drugs and foods acting on the skin from the body. The types are classified as follows.

(1) contact dermatitis: Inflammation of the skin caused by contact with external substances. It has the same symptoms as acute eczema, but differs from eczema in that it occurs as a response to certain externally acting substances. Examples of susceptible substances include lacquer, fig and ginkgo, as well as paints, synthetic resins, leather, rubber, chromium plating, pharmaceuticals, cosmetics and underwear made of synthetic fibers.

(2) Seborrhoic dermatitis: It occurs in the secretion of sebum, such as the head, forehead, and armpits. It is a dermatitis mainly composed of erythema and slender drought. Unlike normal eczema, it is caused by abnormal constitution or sebaceous glands, and the lightest type is dandruff and dryness. Sensitive to sunlight or heat, often worsens in spring and autumn, and is more likely to recur.

(3) atopic dermatitis: Eczema-like skin lesions that occur in atopic dermatitis, also called endogenous eczema and Benny yangjin. Atopic refers to an easy constitution that causes a hypersensitive reaction to food or inhalable substances. Atopic dermatitis can occur at any age, but usually begins in infancy and infants, and most people develop symptoms before age five. Symptoms may relieve or disappear with growth, most of which disappear before puberty and rarely persist in adults. However, the more severe the symptoms, the less likely it is to heal naturally, and even when the symptoms disappear as adults, the skin is usually dry and sensitive to the condition of the skin.

Atopic dermatitis begins with erythematous papules and seizures with severe itching and progresses to acute symptoms with blisters and serous exudates and crusts. The most characteristic symptom is pruritus, which is so severe that it bleeds to bleeding and continues to worsen with a vicious cycle of itching, scratching, and itching.

The pathogenesis and pathophysiology of atopic dermatitis are thought to be due to a combination of genetic and environmental factors and immunological factors, but the exact cause is not known.

In recent years, the incidence of atopic dermatitis has increased worldwide. This is attributed to air pollution, increased exposure to antigens due to changes in residential environment, reduced breastfeeding, and reduced childhood infectious diseases. Estimate. According to a national epidemiological survey conducted by the Korean Academy of Pediatric Allergy and Respiratory Diseases in 1995, 12-24% of elementary school students and 6-8% of middle school students answered that they had been diagnosed with atopic dermatitis, and in 2000, 24.9% of elementary school students 12.8% of middle school students have been diagnosed with atopic dermatitis, and the frequency is increasing in Korea.

Treatment of atopic dermatitis usually aims to alleviate itching and dermatitis, and in most cases, systemic administration of antihistamines to alleviate itching symptoms. In addition, as a basic treatment of atopic dermatitis, steroids (adrenal cortex hormones) with anti-inflammatory and immunosuppressive effects are used to relieve the inflammation of the lesions. If it suddenly worsens, antibiotics are given systemically.

However, such symptomatic therapy is not a fundamental treatment, and corticosteroids inevitably have side effects with long-term use. On the other hand, in the case of refractory atopic dermatitis that does not respond to the above treatment, the combination of ultraviolet treatment and cyclosporin oral preparations, which are immunosuppressive agents, may be helpful, but side effects such as hypertension, nephrotoxicity and hepatotoxicity may occur. Can be.

Therefore, in recent years, interest in herbal treatment methods for such atopic dermatitis has increased, and efforts have been made to develop herbal medicines that have no side effects and can be treated as a source. In oriental medicine, atopic dermatitis is seen as a symptom on the skin as a result of weakened immunity due to weakness of the internal organs, especially lung, rain, and kidneys. Therefore, it is known that not only treatments for improving the symptoms of the skin but also strengthening the lungs to balance the five intestines and smoothing the flow of blood donation are also carried out along with constitution improvement therapy to maintain health.

In the meantime, as a herbal composition for treating atopic dermatitis, the composition for the treatment of skin diseases including rhubarb, rhubarb, yellow white, golden, ringworm and seonhwangwang (Patent No. 2003-0055154), licorice, changja, safflower, pork (pig Herbal composition (public patent 10-2004-0011584) effective in mixing atopic dermatitis, scalp, ginseng, gilyeong, raw yellow sulfur, gold and silver, three hundred seconds, ginger, dermis, baekchul, creation, Astragalus, licorice, Pharmaceutical composition for treating allergic diseases containing peppermint, red pepper, green onion, jujube and medicinal herb as an active ingredient (published patent 10-2004-0030371), dry percentage, uiyiin, Schisandra chinensis, Gilkyung, nachojak, gyngdongdong and Seokchangpo A composition for preventing or treating atopic dermatitis (public patent 10-2004-0050622) and the like has been proposed.

Therefore, the present inventors started with a herbal medicine traditionally known to be effective in treating allergic diseases and skin diseases, and while continuing the clinical experiment process on various herbal plants that are easy to collect in the mountains of Korea, mugwort, snakeberry, The composition comprising the extracts of evening primrose, willow, elm and tangerine and egg yolk oil (vegetable oil) has finally completed the present invention by revealing an excellent effect on dermatitis including atopic dermatitis.

The present invention has been made in order to solve the problems of the above-mentioned known technology, the recent rapid increase, but difficult to cure atopic dermatitis including dermatitis, including the difficult side effects without providing a herbal composition and a method for manufacturing the same will be.

The present invention for achieving the above object, provides a herbal composition for treating dermatitis, including extracts of mugwort, snakeberry, evening primrose, willow, elm and tangerine and egg yolk oil (yolk oil).

 The present invention also provides a method for preparing the herbal composition for treating dermatitis.

Hereinafter, the present invention will be described in detail.

The herbal composition for treating dermatitis of the present invention is characterized in that it comprises the extract of mugwort, snakeberry, evening primrose, willow, elm and tangerine and egg yolk oil (yolk oil).

The wormwood and snakeberry are the whole stems and leaves as well as the roots. Evening primroses are not only the fruit but also the flowers, stems, leaves and roots. Willow and elm are the leaves and stems of the year. The tanza is taken from the ripe fruits of the tanza trees. All of the above herbal materials can be used in the herbal state immediately after being taken or in a dried state. In addition, the extract is obtained by hot water extraction method by mixing or mixing the plant herbal materials, respectively, can be preserved in the form of a concentrated liquid or dry powder.

The egg yolk (卵黃, yolk) refers to the nutritional substances contained in mature unfertilized eggs and pears of chickens, which are oviparous animals, and the egg yolk oil (egg yolk oil) heats the fat contained in the egg yolk It was separated by adding.

Mugwort (Artemisia princeps var. Orientalis) is a perennial herb of the dicotyledon plant Campanula Asteraceae. It is distributed in Korea, Japan, and China, and grows in the size of 60 ~ 120cm in sunny grass. The young leaves of mugwort have been used for edible, stem and leaves for medicinal use. The medicinal herb is harvested from late spring to early summer. The most common use of mugwort is mugwort. When moxa with mugwort increases the number of white blood cells twice as much as usual, it is known to strengthen immunity. Mugwort also has an insecticidal effect, and also acts as a fragrance.

The main components of mugwort are calcium, fiber, vitamin A, vitamin B, and vitamin C. These wormwood contains cineol, cholan, eucalyptol, adenine, monoginine, artemisine, etc., strong blood pressure, detoxification, fever, tonic, gangjeong, anti-inflammatory, analgesic, immunity, diuresis, hemostasis, appetite Efficacy has been found in the back, and recently, it has been found that also has the effect of inhibiting cancer cells. The agreement is written that mugwort is poisonous and controls all chronic diseases, especially for women's diseases and giving birth to children. According to clinical results, it has been reported that fever and blood pressure lowering action, lowering blood sugar level, speeding up recovery of damaged liver, and especially inhibiting hepatitis virus and pandemic virus.

Duchesnea chrysantha is a perennial plant of the Rosaceae of the dicotyledonous plant. It is also called berry, jam, and wild hawk. It is distributed in Korea, China, Japan, Malaysia, and India, and grows in the grass or the hillside. Its roots grow from the nodes as the vines grow to the side. The fruit, despite its name and appearance, tastes neither sweet nor sour.

Folks use the fruit, roots and stems as antipyretics and antitussives. It is effective for skin diseases and circulatory diseases. It is known to stop fever, detoxify, stop coughing and stop blooming. Snake berries show antifungal activity against golden grapes, meningitis twins, erythrocytes, typhoid rods, diphtheria rods, etc., and have been reported to have excellent anti-cancer effects as well as an immune enhancing effect against various diseases.

Evening Primrose (Oenothera odorata) is a biennial plant of the dicotyledonous larvae and is a naturalized plant native to South America Chile, but is distributed throughout the country and grows up to 50 ~ 90cm in heights, roadsides, and glades. Chinese medicine is rooted in the medicine called wolgamcho (月見草), high fever with a cold, sore throat when put into water and take it, and the seeds are used for hyperlipidemia as woldogja (月 見 子).

Native Americans of North America have used wild primroses from ancient times to grind leaves, stems, flowers, and fruits and apply them as external preparations to the affected areas of trauma and skin boils, and also as an oral medicine to soothe coughs and convulsive seizures of asthma. The scientific basis was found to be due to the inclusion of gamma linolenic acid, an essential fatty acid, in the oil from the seeds of evening primrose. Evening primrose oil contains more than 7% to 8% of all fatty acids in the natural form of gamma linolenic acid. Such gamma (γ) -linolenic acid is an unsaturated fatty acid that cannot be synthesized in the body and must be taken from the outside. In nature, it is contained only in evening primroses and breast milk.

Evening Primrose Seed Oil has an excellent effect on disease prevention and health improvement, and is particularly effective in eliminating inflammatory reactions and provoking substances and also for atopic dermatitis and other skin diseases by gamma linolenic acid (omega-6 fatty acid). Is being reported. In particular, a decrease in gamma linolenic acid metabolites has been found in patients with atopic dermatitis, and one of the causes of the rapidly increasing atopic dermatitis is the lack of gamma linolenic acid. When lactating infants do not receive breast milk and are deficient in gamma linolenic acid, atopic dermatitis or asthma is rarely cured.

Willow (Salix koreensis) is a deciduous tree of the dicotyledonous willow tree Willow family, also known as willow or tusks. It is distributed in Korea, Japan, and northeastern China, and is commonly found in fields and streams. It grows about 20m in height and 80cm in diameter.

There are many varieties of willow, most of which can be used as medicines to lower blood pressure, reduce heat, and release lacquer. Willow bark contains tannins, flavonoids, ascorbic acid, glycosides, and fats. Salitin has the effect of reducing the heat and pain in the bones. Willow bark water is effective for pneumonia, colds, fever, cough, headache, urine, etc., killing bacteria and removing inflammation, and has a very strong antiseptic effect. Willow bark helps to relieve pain in fever, which can be used for rheumatoid arthritis, colds, and mucus. Flowers are used for jaundice, spear or knife injuries, stiffening and paralysis due to moisture, swelling, burns, poisoning, and soreness of teeth or gums.

Elm (Ulmus davidiana var. Japonica) is a deciduous broad-leaved tree of the dianthus elmaceae, and is distributed in Korea, Japan, Sakhalin, Kuril Islands, northern China, and East Siberia. It grows to a size of 20m and 60cm in diameter. Chinese characters are used as elm oil or elm powder, and the bark of the bark is called root root. There are many varieties of elm, but the shape of leaves and their use as medicine are the same.

This elm tree has been used as a diuretic medicine, cure or boil medicine since ancient times. Medicines include elm root bark, which contains flavonoids, saponins (hemolysis index 1: 1,900), tannins (3 percent), and a large amount of mucus. It has been reported to enhance the movement of bladder smooth muscle, stop coughing, astringent and anti-inflammatory. Eating the elm root bark essence or applying it to your skin can quickly penetrate and cure various skin diseases and make your skin beautiful and smooth. Elm root bark is also known to have excellent effects on various ulcers such as gastric ulcer, duodenal ulcer, small intestine ulcer and colon ulcer. Elm leaves, on the other hand, act as a natural sleeping pill without side effects, and elm berries have an antiparasitic and antibacterial effect.

Poncirus trifoliata is a deciduous shrub to the dianthus of the dicotyledonous rats. It is native to China and is distributed in the south of Gyeonggi-do. It grows in the size of 3-4m in height, and the fruit is round and yellow and ripens in September. It smells good but cannot be eaten.

Fruits are used as medicines, and the fruits of tangerines are known to relieve skin diseases, crusts of fruit bark, hemorrhoids of root bark, and stems of boils. On the other hand, dried fruit of the tanza is called Ponciri Fructus, which has a peculiar smell, taste, and is used for fragrant gourmet placebo.

Eggs are eggs produced in vitro by female eggs of chickens (Gallus domesticus). Egg yolk consists of 49.4% moisture, 16.2% protein, 32.6% fat, and 1.8% minerals. It contains abundant vitamin A and a small amount of thiamine / riboflavin. The yolk protein is lipobitelin (lipovitellin) and lipovitellenin (lipovitellenin). Egg yolk oil, which is an oil from egg yolk, is known to be effective as an external medicine for hemorrhoids and skin inflammation. The yolk that is not burned starts to harden at 65 ° C and hardens not to flow until it is over 70 ° C.

The herbal composition for treating dermatitis, including the extract of mugwort, snakeberry, evening primrose, willow, elm, and tangerine, and egg yolk oil (egg yolk oil), may be directly applied or orally applied to the affected area of dermatitis depending on the form of the preparation. It is desirable to combine both external and internal use.

The herbal compositions for treating dermatitis are all constituents that have been identified as medicinal plants and plants that are edible and non-toxic, and thus, no additional toxicity test is required.

On the other hand, the herbal composition can be developed as an additive of health foods that can prevent or alleviate the occurrence of dermatitis, including atopic dermatitis, in addition to that can be used in the development of drugs for the treatment of skin diseases, further developed as an additive in cosmetics Of course it can be.

Method for producing a herbal composition for treating dermatitis of the present invention,

1) mugwort 10% to 30%, snakeberry 5% to 15%, evening primrose 10% to 30%, willow 10% to 30%, elm 10% to 30%, tanza Finely chopping and mixing the fruit from 3% by weight to 9% by weight;

2) extracting the herbal ingredients by heating the mixed herbal ingredients and purified water in a container;

3) separating the extract of the plant herbal ingredient by filtering the mixture of the herbal ingredient and the extract; And

4) mixing the egg yolk oil (yolk oil) with the plant herbal extract; Characterized in that consisting of.

The weight ratio of the herbal ingredients of step 1 are all based on the living or frozen state immediately after collection or all dried,

The ratio of the herbal material and purified water of step 2 is 1 (Kg): 1 (L) when all the herbal ingredients are in vivo or frozen storage, and 1 (Kg) when all are dried: Let it be ratio of 1.5 (L)-2 (L). Heating is carried out at a temperature of 80 ° C. to 100 ° C. for 2 hours to 3 hours.

Filtration of the step 3 is to separate the extract containing the solids and the herbal ingredients of the herbal medicine, the extract is preserved in the form of a concentrated liquid by drying or in the state of the filtered liquid solution, or the freeze-drying process of the powder Can be preserved in form.

The method of manufacturing egg yolk oil (vegetable oil) of step 4, after boiling fresh eggs, removes the shell (egg) and whites (egg white), separates only the yolk (egg yolk), crushes them, and puts them in a container at 200 ° C to 300 ° C. Obtained by separate collection of the extract by heating. The mixture is mixed at a ratio of 95% to 99% by volume of the extract of the plant herbal ingredient with 1% to 5% by volume of egg yolk oil (yolk oil), and 0.1% to 0.5% by volume of ethyl alcohol is added as a surfactant. .

The method of manufacturing the herbal composition for treating dermatitis of the present invention configured as described above allows to obtain a herbal composition having excellent effects on dermatitis including atopic dermatitis, and the herbal composition prepared by the above method is used for the preparation of external medicines and external preparations. Processing into any formulation suitable for the method of administration is possible, including in the form of concentrates.

In addition, the preparation method of the herbal composition for treating dermatitis of the present invention configured as described above is applied as a method for preparing a health food additive composition which can prevent or alleviate the occurrence of dermatitis including atopic dermatitis, or the occurrence of dermatitis including atopic dermatitis. It can be applied as a method of manufacturing a cosmetic composition that can prevent or alleviate.

Hereinafter, the present invention will be described in more detail with reference to Examples.

However, the following examples are merely to exemplify the contents of the present invention, and the scope of the present invention is not limited to the examples.

Example 1 Preparation of a herbal composition for treating dermatitis

1 Kg of mugwort (whole herb with roots, living state immediately after harvesting) and 0.5 Kg of snakeberry (whole herb with roots, biological state immediately after harvesting) and evening primrose (whole herb including roots, living body immediately after harvesting) 1 year old stems, fresh stems immediately after harvest) and 1 kg g of elm (leaf and annual stems, fresh stems immediately after harvest) and tangerine (raw fruit, about a third of the weight of the dry body). 0.2Kg was finely chopped and mixed, 5L of water was added thereto, heated at 90 ° C. for 3 hours, and filtered through a cloth to obtain 2 L of extract concentrate.

Peeled 20 boiled eggs were removed, the whites were removed, only the yolks were separated, crushed, crushed and placed in a container and heated at 300 ° C. for 30 minutes to obtain 50 ml of egg yolk oil (yolk oil).

50 ml of the egg yolk oil (egg yolk oil) was mixed with 2 L of the extract water concentrate, and 2.5 ml of ethyl alcohol (10 ml of 25% dilution distilled soju) was added to prepare a 2060 ml herbal composition for treating dermatitis.

<Test Example 1> The dermatitis treatment effect of the herbal composition

The herbal composition obtained as a result of Example 1 was applied to the affected area by atopic dermatitis patients who volunteered the test between June and August 2004, and the following results were obtained. The following subjects were chronic patients who had not seen any improvement of symptoms by hospital treatment. After applying the herbal composition to the affected area 30 times a day for 30 times twice a day, all were satisfied with the treatment effect and reported side effects. There was no case.

name date of birth address effect Lee Hyung Woo 1950.11.09 # 1010, Yuchang High Living, Yongbong-dong, Buk-gu, Gwangju cure Sang-Ok Kim 1956.05.13 # 102, 105, Kumho Apartment, Gyerim-dong, Dong-gu, Gwangju cure An Sung Bok 1966.01.15 # 807, 101, Maegok-dong, Buk-gu, Gwangju cure Former Nakho 1968.03.15 # 405, 502, Siyeong Apartment, Geumho-dong, Seo-gu, Gwangju cure Seo 1971.01.07 401-1212, Seola 4-cha Apartment, 861 Ilsim-ri, Hwasun-eup, Hwasun-gun, Jeonnam cure Lee Jae Woo November 30, 1971 181-32 Usan-dong, Buk-gu, Gwangju cure Choi Young Rang 1974.10.24 # 814, 105, Ilsan Apartment, Unam-dong, Buk-gu, Gwangju cure Dong Won Lee 1976.07.03 956-7, Wolsan 4-dong, Nam-gu, Gwangju cure Kim Young Bum 1976.08.07 # 901, 306 Dong Jugong Apartment Building, Dongrim-dong, Buk-gu, Gwangju cure Young-un Jo 1992.07.06 # 305, Unam Apartment 42, Unam-dong, Buk-gu, Gwangju cure

Test Example 2 Hair Dandruff Treatment Effect of Herbal Composition

When the herbal composition obtained as a result of Example 1 was applied to the affected area by the hair dandruff patient who volunteered the test between March and May 2004, the following results were obtained. The following subjects were also chronic patients with severe hair dandruff. After applying the herbal medicine to the affected area for 30 times twice a day, all of them were satisfied with the therapeutic effect, and no side effects were reported.

name date of birth address effect Lee Hyung Woo 1950.11.09 # 1010, Yuchang High Living, Yongbong-dong, Buk-gu, Gwangju cure Yun Gi Kim 1955.02.09 352-1, Gakhwa-dong, Buk-gu, Gwangju cure River Hong Bo 1960.03.25 # 303, Kumho Apartment, Maegok-dong, Buk-gu, Gwangju cure Seo Shun Bong 1968.01.20 205, Ochi Suitesville, Ochi-dong, Buk-gu, Gwangju cure Yeom Seung Hak 1970.04.29 874-7, Sangmu 2-dong, Seo-gu, Gwangju cure Chae Seung-hak 1976.02.28 # 1 220, Life 1-dong, Sok-dong, Mokpo-si, Jeonnam cure Yeonhwa Kim 1977.01.24 108-5, Yanglim-dong, Nam-gu, Gwangju cure Somi Young November 13, 1980 28-4, Wolsan 1-dong, Nam-gu, Gwangju cure

As described above, the herbal composition for treating dermatitis of the present invention and a method for manufacturing the same can enable the development of an effective therapeutic agent without side effects while being capable of fundamental treatment for dermatitis including atopic dermatitis, which is rapidly increasing and difficult to treat in recent years. do.

In addition, the herbal composition for treating dermatitis of the present invention and a method of manufacturing the same are health food additives and cosmetic additives to prevent or alleviate the occurrence of dermatitis, including atopic dermatitis, many modern people, including so-called sick house syndrome, which cannot avoid environmental pollution. Enable development

Claims (5)

1) mugwort 10% to 30%, snakeberry 5% to 15%, evening primrose 10% to 30%, willow 10% to 30%, elm 10% to 30%, tanza Finely chopping and mixing the fruit from 3% by weight to 9% by weight; 2) extracting the herbal ingredients by heating the mixed herbal ingredients and purified water in a container; 3) separating the extract of the plant herbal ingredient by filtering the mixture of the herbal ingredient and the extract; And 4) mixing the plant herb extract 95 to 99% by volume and egg yolk oil (yolk oil) 1% to 5% by volume; Method for producing a herbal composition for treating dermatitis, characterized in that consisting of. A herbal composition for treating dermatitis prepared by the method of claim 1. delete delete delete