CN109223990A - Pass through the Chinese medicine composition and preparation method thereof of ear acupoint application treatment facial paralysis - Google Patents
Pass through the Chinese medicine composition and preparation method thereof of ear acupoint application treatment facial paralysis Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 208000004929 Facial Paralysis Diseases 0.000 title claims abstract description 33
- 208000036826 VIIth nerve paralysis Diseases 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
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- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 15
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- 235000008434 ginseng Nutrition 0.000 claims abstract description 15
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims abstract description 12
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- A61K36/232—Angelica
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof by ear acupoint application treatment facial paralysis, are made of following raw material components: 20 parts of Radix Angelicae Sinensis, 15 parts of radix achyranthis bidentatae, 12 parts of Rhizoma Gastrodiae, 15 parts of Rhizoma Atractylodis Macrocephalae, 6 parts of ginseng, 12 parts of Rhizoma Chuanxiong, 12 parts of fructus lycii, 20 parts of Radix Astragali, 15 parts of Radix Notoginseng, 12 parts of cordyceps sinensis and 10 parts of safflower.Preparation method: weighing each raw material component in proportion, dry after cleaning, crushing；It decocts and extracts later, filter and collect filtrate；Paste is concentrated the filtrate to, Chinese medicine composition is obtained.The traditional chinese medicine composition of the invention selects the Chinese medicinal material containing active skull cap components, prescription proportion science, it is mild non-stimulated, safe without toxic side effect, it is flexible and convenient when use, have the function of excellent cold extermination warm blood, increase immunity, fast quick-recovery of face and other effects, it can be effective for root pain after treatment facial neural convulsion, wry mouth and heterotropia, ear, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the diseases such as the cold acid of face deadlock is swollen.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of Chinese medicine group by ear acupoint application treatment facial paralysis
Close object and preparation method thereof.
Background technique
It is well known that facial paralysis (facioplegia, facial paralysis, wry mouth and heterotropia) is with facial expression muscle movement dysfunction
For a kind of common disease, the frequently-occurring disease of main feature.Chinese medicine thinks: before generation, most of patients has under tired and physical strength this disease
The case where drop；And Chinese medicine thinks, the occurrence of this disease main cause is because " healthy tendency " void relatively is in heresy interior, that Head And Face is had a cold
Caused by invasion.As being sayed in " General Treatise on the Cause and Symptoms of Diseases ": askew hemiplegia mouth is physically weak wind-engaging, enables mouth askew out-of-the-way.The heresy of chill invades people
Body causes blockage of channel, and qi and blood numbness hinders among passages through which vital energy circulates, leads to passages through which vital energy circulates dystrophy and this disease occurs.
In addition, facial paralysis is as a kind of common disease, frequently-occurring disease, not by age limit.General symptom is facial paralysis, and patient is past
It is all unable to complete toward movements such as most basic lift eyebrow, eye closing, drum mouths；Its cause of disease 80% is fallen ill the above are virus infection, hair
The duration of an exhibition is 5~6 days, and other wounds, inflammation etc. can also fall ill.In current treatment method, doctor trained in Western medicine is with antiviral and trophic nerve
Drug therapy, but antiviral drugs can not be such that the facial nerve being damaged restores, and the drug of trophic nerve can not make its extensive
Multiple, often acute stage, needs to go to department of traditional Chinese medicine and applies acupuncture and Chinese medicine treatment.Chinese medicine acupuncture, acusector, Chinese medicine therapeutic effect are slow,
It can be cured compared with less serious case, severe one is difficult to cure, and acupuncture leaves serious sequelae, such as prosopospasm, is difficult to cure.
Based on this, the Chinese medicine composition of a kind of obvious effect and the facial paralysis with powerful applicability is needed, to alleviate
The pain of many patients.
Summary of the invention
For the defects in the prior art, the present invention is intended to provide a kind of Chinese medicine by ear acupoint application treatment facial paralysis
Composition and preparation method thereof.The Chinese medicine composition of facial paralysis of the present invention selects the Chinese medicinal material containing active skull cap components,
Prescription proportion science, mild non-stimulated, safe without toxic side effect, when use, are flexible and convenient, have excellent cold extermination warm blood, increase
Immunity, the fast quick-recovery of face's function and other effects, can be askew effective for facial neural convulsion caused by facial paralysis sequelae, mouth
Eye tiltedly, root pain after ear, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the diseases such as the cold acid of face deadlock is swollen.
For this purpose, the invention provides the following technical scheme:
In a first aspect, the present invention provides a kind of Chinese medicine composition for facial paralysis, raw material components by weight, are wrapped
It includes: 10~30 parts by weight of Radix Angelicae Sinensis, 5~20 parts by weight of radix achyranthis bidentatae, 5~20 parts by weight of Rhizoma Gastrodiae, 10~30 parts by weight of Rhizoma Atractylodis Macrocephalae, ginseng 3~7
Parts by weight, 5~20 parts by weight of Rhizoma Chuanxiong, 5~20 parts by weight of fructus lycii, 10~30 parts by weight of Radix Astragali, 5~20 parts by weight of Radix Notoginseng, winter worm
2~20 parts by weight of 3~20 parts by weight of summer grass and safflower.
Preferably, raw material components include: 20 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Rhizoma Gastrodiae, 15 weight of Rhizoma Atractylodis Macrocephalae
Part, 6 parts by weight of ginseng, 12 parts by weight of Rhizoma Chuanxiong, 12 parts by weight of fructus lycii, 20 parts by weight of Radix Astragali, 15 parts by weight of Radix Notoginseng, cordyceps sinensis 12
10 parts by weight of parts by weight and safflower.
Preferably, raw material components include: 30 parts by weight of Radix Angelicae Sinensis, 5 parts by weight of radix achyranthis bidentatae, 20 parts by weight of Rhizoma Gastrodiae, 30 weight of Rhizoma Atractylodis Macrocephalae
Part, 3 parts by weight of ginseng, 5 parts by weight of Rhizoma Chuanxiong, 20 parts by weight of fructus lycii, 10 parts by weight of Radix Astragali, 20 parts by weight of Radix Notoginseng, 3 weight of cordyceps sinensis
Measure part and 20 parts by weight of safflower.
Preferably, raw material components include: 10 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of radix achyranthis bidentatae, 6 parts by weight of Rhizoma Gastrodiae, 10 weight of Rhizoma Atractylodis Macrocephalae
Part, 7 parts by weight of ginseng, 20 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of fructus lycii, 30 parts by weight of Radix Astragali, 5 parts by weight of Radix Notoginseng, 20 weight of cordyceps sinensis
Measure part and 2 parts by weight of safflower.
It should be noted that each bulk pharmaceutical chemicals of preparation the traditional chinese medicine composition of the invention are matched according to parts by weight, producing
When can according to corresponding ratio increase or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production
Can in grams, weight can increase or reduce, but the bulk pharmaceutical chemicals quality proportioning constant rate between each composition.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition, comprising the following steps: S1: claim in proportion
Each raw material component is taken, it is dry after cleaning, crushing；S2: each raw material component after drying is subjected to decoction extraction, filters and receives later
Collect filtrate；S3: concentrating the filtrate to paste, obtains Chinese medicine composition.
Preferably, in S1, each raw material component is crushed to 60~200 mesh.
Preferably, in S2, the time for decocting extraction is 50~100min, and preferably first boils 5~10min by intense fire, later
It is boiled by slow fire again.
The third aspect, Chinese medicine composition provided by the invention are quick in preparation cold extermination warm blood, increase immunity, face's function
The drug of recovery and/or the application in medicated premix.Preferably, the fast quick-recovery of face's function includes caused by facial paralysis
Root pain after facial neural convulsion, wry mouth and heterotropia, ear, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the stiff cold acid of face is swollen
One of or it is a variety of.Specifically, by Chinese medicine composition plug of the invention in Ipsilateral ear mouth, drug effect is gone directly lesion, and can be straight
The facial nerve for acting on entire side is connect, to cure facial paralysis；It is preferred that once a day, and 12 days as a treatment course.
The above technical solution of the present invention has the following advantages over the prior art:
(1) applicant has found by numerous studies: the Chinese medicine composition selection of facial paralysis of the present invention contains natural activity
The Chinese medicinal material of ingredient, prescription proportion science, mild non-stimulated, safe without toxic side effect, when use, are flexible and convenient, have excellent
Cold extermination warm blood, increase immunity, the fast quick-recovery of face's function and other effects, can be effective for face caused by facial paralysis sequelae
Root pain after portion's nerve spasm, wry mouth and heterotropia, ear, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the stiff cold acid of face is swollen etc.
Disease.
(2) preparation method provided by the invention is used, the same of each bulk pharmaceutical chemicals active constituent can retained to greatest extent
When, the effective component in each raw medicinal material can sufficiently be released, to make the Chinese medicine composition being finally prepared not
Only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for curing various diseases.
(3) Chinese medicine composition of facial paralysis provided by the invention has powerful applicability, removes neuronal edema, is also applicable in
Facial paralysis caused by wound etc. or even the rare auditory nerve time postoperative facial paralysis of tumor can also cure in ear.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical solution of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following embodiment, is all provided with
Three repeated experiments are set, data are the average value or mean+SD of three repeated experiments.
Radix Angelicae Sinensis as used in the following examples, radix achyranthis bidentatae, Rhizoma Gastrodiae, Rhizoma Atractylodis Macrocephalae, ginseng, Rhizoma Chuanxiong, fructus lycii, Radix Astragali, Radix Notoginseng, worm summer in winter
Grass and safflower meet the pertinent regulations under each medicinal material item of " Chinese Pharmacopoeia " text.Before feeding intake, by identification, ingredients is real
Object is consistent with title, and quality complies with standard.It is illustrated With reference to embodiment:
The present invention provides a kind of Chinese medicine composition for facial paralysis, and raw material components are by weight, comprising: Radix Angelicae Sinensis 10
~30 parts by weight, 5~20 parts by weight of radix achyranthis bidentatae, 5~20 parts by weight of Rhizoma Gastrodiae, 10~30 parts by weight of Rhizoma Atractylodis Macrocephalae, 3~7 parts by weight of ginseng, river
5~20 parts by weight of rhizome of chuanxiong, 5~20 parts by weight of fructus lycii, 10~30 parts by weight of Radix Astragali, 5~20 parts by weight of Radix Notoginseng, cordyceps sinensis 3~20
2~20 parts by weight of parts by weight and safflower.
In addition, being directed to above-mentioned Chinese medicine composition, applicant specially devises preparation method, comprising the following steps:
S1: weighing each raw material component in proportion, cleans, is crushed to 60~200 mesh, dries later.
S2: each raw material component after drying decoct and extracts 50~100min, and first boils 5~10min by intense fire, it
It is boiled by slow fire again afterwards；Filtrate is filtered and collected later, obtains Chinese medicine composition.
It is illustrated With reference to embodiment:
Embodiment one
The present embodiment provides a kind of Chinese medicine compositions for facial paralysis, are prepared by following raw material components: Radix Angelicae Sinensis
20 parts by weight, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Rhizoma Gastrodiae, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, 6 parts by weight of ginseng, 12 parts by weight of Rhizoma Chuanxiong, fructus lycii
12 parts by weight, 20 parts by weight of Radix Astragali, 10 parts by weight of 15 parts by weight of Radix Notoginseng, 12 parts by weight of cordyceps sinensis and safflower.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 100 mesh, dries later.
S2: each raw material component after drying decoct and extracts 80min, and first boils 8min by intense fire, later mild fire again
It boils；Filtrate is filtered and collected later, obtains Chinese medicine composition.
Embodiment two
The present embodiment provides a kind of Chinese medicine compositions for facial paralysis, are prepared by following raw material components: Radix Angelicae Sinensis
30 parts by weight, 5 parts by weight of radix achyranthis bidentatae, 20 parts by weight of Rhizoma Gastrodiae, 30 parts by weight of Rhizoma Atractylodis Macrocephalae, 3 parts by weight of ginseng, 5 parts by weight of Rhizoma Chuanxiong, fructus lycii 20
Parts by weight, 10 parts by weight of Radix Astragali, 20 parts by weight of 20 parts by weight of Radix Notoginseng, 3 parts by weight of cordyceps sinensis and safflower.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 60 mesh, dries later.
S2: each raw material component after drying decoct and extracts 100min, and first boils 10min by intense fire, literary again later
Fire boils；Filtrate is filtered and collected later, obtains Chinese medicine composition.
Embodiment three
The present embodiment provides a kind of Chinese medicine compositions for facial paralysis, are prepared by following raw material components: Radix Angelicae Sinensis
10 parts by weight, 20 parts by weight of radix achyranthis bidentatae, 6 parts by weight of Rhizoma Gastrodiae, 10 parts by weight of Rhizoma Atractylodis Macrocephalae, 7 parts by weight of ginseng, 20 parts by weight of Rhizoma Chuanxiong, fructus lycii 5
Parts by weight, 30 parts by weight of Radix Astragali, 2 parts by weight of 5 parts by weight of Radix Notoginseng, 20 parts by weight of cordyceps sinensis and safflower.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 200 mesh, dries later.
S2: each raw material component after drying decoct and extracts 50min, and first boils 5min by intense fire, later mild fire again
It boils；Filtrate is filtered and collected later, obtains Chinese medicine composition.
Comparative example
This comparative example provides a kind of Chinese medicine composition for facial paralysis, is prepared by following raw material components: Radix Angelicae Sinensis
20 parts by weight, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Rhizoma Gastrodiae, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, 6 parts by weight of ginseng, 12 parts by weight of Rhizoma Chuanxiong, Radix Astragali
20 parts by weight, 10 parts by weight of 15 parts by weight of Radix Notoginseng, 12 parts by weight of cordyceps sinensis and safflower.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 100 mesh, dries later.
S2: each raw material component after drying decoct and extracts 80min, and first boils 8min by intense fire, later mild fire again
It boils；Filtrate is filtered and collected later, obtains Chinese medicine composition.
In addition, the effect of in order to further evaluate each embodiment Chinese medicine composition, carry out following clinical trial:
Call-up age 18~50 years old facial paralysis patient 100 (male to female ratio 1:1).The Symptoms of patient are as follows: face
Root pain after neural spasm, wry mouth and heterotropia, ear, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the diseases such as the stiff cold acid of face is swollen
Shape.Specifically, patient is divided into 4 groups, every group of 25 people try out the Chinese medicine composition of embodiment and comparative example respectively.It is specific to use
Method are as follows: after cleaning skin, take the Chinese medicine composition plug of 3~5g in Ipsilateral ear mouth.Continuously try out Chinese medicine group provided by the invention
It closes object 12 days, records the curative effect of each patient, specific data are as shown in table 1.
Observation of curative effect standard is divided into healing, effective and invalid；Cure: symptom disappears；Effective: symptom mitigates；It is invalid: symptom
Without any change.
The curative effect statistical form of each embodiment and comparative example facial paralysis patient of table 1
| It cures | It is effective | In vain | |
| Embodiment one | 23 | 2 | 0 |
| Embodiment two | 21 | 4 | 0 |
| Embodiment three | 20 | 5 | 0 |
| Comparative example | 15 | 10 | 0 |
Certainly, the case where being enumerated in addition to embodiment one to embodiment three, the type and weight percent of other raw material components,
Condition and parameter in preparation process etc. are also possible.
The Chinese medicine composition of facial paralysis of the present invention selects the Chinese medicinal material containing active skull cap components, prescription proportion section
It learns, mild non-stimulated, safe without toxic side effect, when use is flexible and convenient, has excellent cold extermination warm blood, increases immunity, face
Fast quick-recovery of portion's function and other effects, can be effective for facial neural convulsion caused by facial paralysis sequelae, wry mouth and heterotropia, ear after
Root pain, facial numbness/pain, the linkage of mouth eye, facial muscle atrophy, the diseases such as the stiff cold acid of face is swollen.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (9)
1. a kind of Chinese medicine composition for facial paralysis, which is characterized in that raw material components are by weight, comprising:
10~30 parts by weight of Radix Angelicae Sinensis, 5~20 parts by weight of radix achyranthis bidentatae, 5~20 parts by weight of Rhizoma Gastrodiae, 10~30 parts by weight of Rhizoma Atractylodis Macrocephalae, ginseng 3~
7 parts by weight, 5~20 parts by weight of Rhizoma Chuanxiong, 5~20 parts by weight of fructus lycii, 10~30 parts by weight of Radix Astragali, 5~20 parts by weight of Radix Notoginseng, winter worm
2~20 parts by weight of 3~20 parts by weight of summer grass and safflower.
2. the Chinese medicine composition according to claim 1 for facial paralysis, it is characterised in that:
20 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Rhizoma Gastrodiae, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, 6 parts by weight of ginseng, 12 weight of Rhizoma Chuanxiong
Measure part, 12 parts by weight of fructus lycii, 20 parts by weight of Radix Astragali, 10 parts by weight of 15 parts by weight of Radix Notoginseng, 12 parts by weight of cordyceps sinensis and safflower.
3. the Chinese medicine composition according to claim 1 for facial paralysis, it is characterised in that:
30 parts by weight of Radix Angelicae Sinensis, 5 parts by weight of radix achyranthis bidentatae, 20 parts by weight of Rhizoma Gastrodiae, 30 parts by weight of Rhizoma Atractylodis Macrocephalae, 3 parts by weight of ginseng, 5 weight of Rhizoma Chuanxiong
Part, 20 parts by weight of fructus lycii, 10 parts by weight of Radix Astragali, 20 parts by weight of 20 parts by weight of Radix Notoginseng, 3 parts by weight of cordyceps sinensis and safflower.
4. the Chinese medicine composition according to claim 1 for facial paralysis, it is characterised in that:
10 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of radix achyranthis bidentatae, 6 parts by weight of Rhizoma Gastrodiae, 10 parts by weight of Rhizoma Atractylodis Macrocephalae, 7 parts by weight of ginseng, 20 weight of Rhizoma Chuanxiong
Part, 5 parts by weight of fructus lycii, 30 parts by weight of Radix Astragali, 2 parts by weight of 5 parts by weight of Radix Notoginseng, 20 parts by weight of cordyceps sinensis and safflower.
5. the preparation method of any one of Claims 1 to 4 Chinese medicine composition, which comprises the following steps:
S1: weighing each raw material component in proportion, dry after cleaning, crushing；
S2: each raw material component after the drying is subjected to decoction extraction, filters later and collects filtrate；
S3: the filtrate is concentrated into paste, obtains the Chinese medicine composition.
6. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that:
In the S1, each raw material component is crushed to 60~200 mesh.
7. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that:
In the S2, the time for decocting extraction is 50~100min, and preferably first boils 5~10min by intense fire, literary again later
Fire boils.
8. any one of Claims 1 to 4 Chinese medicine composition is quick in preparation cold extermination warm blood, increase immunity, face's function
The drug of recovery and/or the application in medicated premix.
9. application according to claim 8, it is characterised in that:
The fast quick-recovery of face's function includes root pain, facial numbness/pain, mouth after facial neural convulsion, wry mouth and heterotropia, ear
Eye linkage, facial muscle atrophy, one of the cold acid of face deadlock is swollen or a variety of.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370895A (en) * | 2010-08-24 | 2012-03-14 | 丰建萍 | Traditional Chinese medicine composition for treating facial paralysis |
| CN107550974A (en) * | 2017-10-30 | 2018-01-09 | 潘畅 | Externally-applied medicinal composition of facial paralysis and application thereof |
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2018
- 2018-11-21 CN CN201811392787.5A patent/CN109223990A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370895A (en) * | 2010-08-24 | 2012-03-14 | 丰建萍 | Traditional Chinese medicine composition for treating facial paralysis |
| CN107550974A (en) * | 2017-10-30 | 2018-01-09 | 潘畅 | Externally-applied medicinal composition of facial paralysis and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 胡树能: "补阳还五散加味贴敷治疗面瘫", 《家庭中医药》 * |
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