CN106177446B - It is a kind of for treating the Chinese materia medica preparation of bell paralysis - Google Patents
It is a kind of for treating the Chinese materia medica preparation of bell paralysis Download PDFInfo
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Abstract
A kind of is with Radix Angelicae Sinensis, Rhizoma Chuanxiong, scorpio, centipede, rhizoma typhonii, Rhizoma Et Radix Notopterygii, rhizoma polygonati, Radix Astragali, thizoma curculiginis, HERBA EPIMEDII for treating the Chinese materia medica preparation of bell paralysis, and Radix Glycyrrhizae is bulk pharmaceutical chemicals, is prepared into oral preparations according to the common process and auxiliary material of pharmacy of Chinese materia medica.Clinical trial shows, Chinese materia medica preparation of the present invention has significant clinical efficacy to treatment bell paralysis, it is substantially shorter the course for the treatment of, patient facial region's nervous function and every facioplegia symptom can be effectively improved, significantly improve the facial body and social function of patient, improve the facial disabled degree of patient, promotes the recovery of facial paralysis patient facial muscle muscular strength.The Chinese herbal medicine of the drug utilization without any toxicity and side effects is bulk pharmaceutical chemicals, safely, effectively, without side-effects to human body, is worth clinically promotion and application.
Description
Technical field
The present invention relates to a kind of Chinese materia medica preparations for treating bell paralysis, belong to technical field of Chinese medicine.
Background technique
Bell paralysis (Idiopathic facial palsy) is also known as facial neuritis (facial
Neuritis), Bell's palsy (Bell ' s palsy), be because of facial nerve nonspecific inflammation in stylomastoid foramen caused by peripheral face
Neuroparalysis clinically to be known as peripheral facial paralysis more.Common symptom be volume line disappear, cannot the volume of wrinkling frown, palpebral fissure cannot close
It closes or dysraphism, double eyeball top rotation outward, exposes white sclera when eye closing；Nasolabial groove shoals, ptosis of labial angle, grinningly when
Bicker is askew to strong side；Air-blowing, gas leakage of whistling, food are easily detained sick side gums etc..The bell paralysis cause of disease is unknown, more
Since virus infection, autonomic nervous function shakiness lead to local nerve nutrient vessel spasm, neural ischemia, oedema cause facial nerve
It is pressurized in bone facial canal and facial muscle paralysis occurs.
In China, the annual disease incidence of facial neuritis is (26-34)/100,000, and illness rate is about 2,58/,100,000, age of onset
It is most commonly seen with 20~40 years old, male compared with women be it is common, have 75%~90% patient that can fully recover, but still have 15%~20% trouble
There are different degrees of facial nerve function obstacles by person, such as facial spasm, facial muscle synkinesia, the unusual sense of taste and crocodile tear sign
Deng.Bell paralysis generally in acute attack, can spontaneous remission, not threat to life is common clinical and multiple
Disease.Although bell paralysis is without lethal danger, due to influencing image appearance after illness, caused to patient's body and mind larger
Pain, so that patient is generated huge psychological pressure, show as the symptoms such as fear, anxiety, and then it is normal to have seriously affected patient
Work and life.Therefore the effective treatment means for actively inquiring into bell paralysis are the main of current medical personnel
Task.
Chinese medicine thinks that bell paralysis disease is due to working excessively, and healthy energy is insufficient, blood virtual loss, and train of thought is hollow,
Battalion defends imbalance, striae of the skin and muscles being loose, weakened defensive QI, and heresy of chill or wind-heat is taken advantage of a weak point in opponent's defence invasion human body, above alters and hangs out in face, contamination flesh
Skin enters through middle network, so that facial sun is bright, few positive two block through passages through which vital energy circulates, muscles along the regular meridians dystrophy, muscle is indulged to delay and do not receive and fall ill.Therefore it treats
The method of upper more dispelling wind and removing obstruction in the meridians, can also cooperate acupuncture, massage etc. to treat.The common drug of Western medicine such as cortex hormone of aadrenaline (fill in
Meter Song, hydrocortisone, prednisone etc.), antiviral agent, trophic nerve medicine (vitB6, vitB1, vitB12 etc.).Wherein hormone
It is most common drug, although can reduce the inflammatory edema of facial nerve using hormone in early days, alleviates symptom, but there are many for hormone
Contraindication and side effect.
Our seminars in long-term clinical practice, according to the Pathogenesis Theory of Chinese medicine and combine clinical development go out to treat it is special
" the wind-dispelling particle " for sending out peripheral facial paralysis, is by Radix Angelicae Sinensis, Rhizoma Chuanxiong, scorpio, bombyx batryticatus, Radix Astragali, centipede, Radix Isatidis, Radix Paeoniae Alba, Radix Glycyrrhizae
Deng composition (" western traditional Chinese medicine " the 10th the 82-83 pages of phases of volume 26 in 2013).Clinical test results are shown, are somebody's turn to do " wind-dispelling particle " and are existed
It treats bell paralysis and obtains good therapeutic effect: treatment group's cure rate 54.82%, obvious effective rate 29.95%, control group cure rate
41.58%, obvious effective rate 26.84%, curative effect compares between 2 groups, and difference is statistically significant (P < 0.01).Treatment group's total effective rate is high
In control group, difference is statistically significant (P < 0.05).Although we achieve certain achievement under study for action, however, I
Still with for this research achievement it is not satisfactory.
Summary of the invention
In order to solve the problems in the prior art, the purpose of the present invention is to a kind of body significantly more treatment idiopathics of curative effect
The Chinese materia medica preparation of facioplegia.
The present invention passes through the disease to bell paralysis disease on the basis of " the wind-dispelling particle " that this seminar develops
Because having done further in-depth study, on the basis of " wind-dispelling particle " prescription, by adjusting the ratio of prescription, each component, into
And improve the mechanism of action of drug, to reach better therapeutic effect.
The Chinese materia medica preparation of bell paralysis of the invention is with Radix Angelicae Sinensis, Rhizoma Chuanxiong, scorpio, centipede, rhizoma typhonii, Qiang
Living, rhizoma polygonati, Radix Astragali, thizoma curculiginis, HERBA EPIMEDII, Radix Glycyrrhizae is that bulk pharmaceutical chemicals carry out prescription.The present invention on the basis of " wind-dispelling particle " prescription,
Bombyx batryticatus, Radix Isatidis, three taste of Radix Paeoniae Alba have been deleted, while having increased rhizoma typhonii again, Rhizoma Et Radix Notopterygii, rhizoma polygonati, thizoma curculiginis, the HERBA EPIMEDII five tastes.Wherein
Radix Angelicae Sinensis, Rhizoma Chuanxiong blood circulation promoting nourishes blood；Scorpio, centipede expelling wind and relieving convulsion, remove obstruction in channels to relieve pain；Radix Astragali invigorating qi for consolidating superficies；Rhizoma typhonii, acrid flavour, sweet, property
Temperature, it is toxic.Return stomach, Liver Channel.With wind-dispelling phlegm, the effect of arresting convulsion is jerked, detoxicating and resolving a mass, analgesic.Rhizoma Et Radix Notopterygii, warm-natured, dispellieg cold and dampness is used for
Affection of exogenous wind-cold, headache and adiapneustia, cold-dampness numbness, upper limb rheumatalgia pain.Rhizoma polygonati, sweet and neutral.Returns spleen, lung, kidney channel.With boosting qi and nourishing yin, it is good for
Spleen, moistening lung, the function of kidney-nourishing.Thizoma curculiginis, warm-natured, acrid flavour is micro- salty.Enter kidney, Liver Channel.Function: there is warm kidney sun, the benefits of strengthening the bone.Celestial spirit
Spleen, also known as Herba Epimedii, warm-natured, acrid flavour enters liver and kidney channel.Have effects that tonifying kidney and strengthening yang, dispelling wind and eliminating dampness.The present invention is white by increasing
Monkshood, Rhizoma Et Radix Notopterygii, rhizoma polygonati, thizoma curculiginis, the HERBA EPIMEDII five tastes further enhance the effect that QI invigorating consolidates, and make itself and Radix Angelicae Sinensis, Rhizoma Chuanxiong,
Scorpio, centipede, after cooperation, wind-dispelling, removing toxic substances, dredging collateral function greatly enhanced, bell paralysis disease is controlled
Therapeutic effect is significantly improved.
In Chinese materia medica preparation of the present invention, each raw material is matched by following parts by weight: 40-50 parts of Radix Angelicae Sinensis, 15-25 parts of Rhizoma Chuanxiong,
3-8 parts of scorpio, 3-8 parts of centipede, 6-12 parts of rhizoma typhonii, 6-12 parts of Rhizoma Et Radix Notopterygii, 15-22 parts of rhizoma polygonati, 15-22 parts of Radix Astragali, thizoma curculiginis 6-12
Part, 6-12 parts of HERBA EPIMEDII, 3-8 parts of Radix Glycyrrhizae.
Optimum ratio: 43-47 parts of Radix Angelicae Sinensis, 18-22 parts of Rhizoma Chuanxiong, 5-6 parts of scorpio, 5-6 parts of centipede, 8-10 parts of rhizoma typhonii, Qiang
It is 8-10 parts, 18-20 parts of rhizoma polygonati, 18-20 parts of Radix Astragali, 8-10 parts of thizoma curculiginis, 8-10 parts of HERBA EPIMEDII, 5-8 parts of Radix Glycyrrhizae living.
Optimum proportioning: 45 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiong, 5 parts of scorpio, 5 parts of centipede, 10 parts of rhizoma typhonii, 10 parts of Rhizoma Et Radix Notopterygii, rhizoma polygonati 20
Part, 20 parts of Radix Astragali, 10 parts of thizoma curculiginis, 10 parts of HERBA EPIMEDII, 5 parts of Radix Glycyrrhizae.
Chinese materia medica preparation of the invention can be prepared into oral preparations according to the common process and auxiliary material of pharmacy of Chinese materia medica, such as oral administration
Preparation is capsule, granule, tablet, pill etc..
Illustrate that pharmaceutical preparation of the present invention does specifically the therapeutic effect of bell paralysis below by clinical data
Explanation.
1 clinical data
1.1. case selection standard
1.1.1 tcm diagnosis standard
The national teaching material " science of acupuncture and moxibustion " of reference regular higher education " 15 " (Shi Xuemin chief editor, China Traditional Chinese Medicine Publishing House,
2007).
(1) onset is unexpected, spring and autumn be it is more, often have catch cold history or have one side cheek, in ear, the pain after ear at Wangue or hair
Heat.
(2) side face is stiff, numb, sheds tears, and volume line disappears, and nasolabial groove shoals, and eye cannot be closed, and bicker is led to strong side
It draws.
(3) side cannot close one's eyes, and the drum cheek grinningly waits movement.
(4) electromyogram can behave as exception.
1.1.2 Western medicine diagnostic criteria
Referring to regular higher education " 15 " National planning teaching material " neurology " the 5th edition (Wang Weizhi chief editor, the people
Health, which is published, shuts out, and 2004).
(1) medical history: onset is anxious, history of drying of often suffering from cold, or has virus infection history.
(2) show: side facial expression muscle is paralysed suddenly, sick side volume line disappears, and palpebral fissure cannot be closed, and nasolabial groove shoals,
Ptosis of labial angle rouses the cheek, gas leakage when whistling, and food is easily stranded between the tooth cheek of disease side, can listen with 2/3 ageusia before sick side tongue
Feel allergy, more tears etc..
(3) brain CT, MRI checks normal.
Grade scale
Using House-Brackmann facial nerve function grade form[1], the table is by U.S.'s Head and neck tumour --- otolaryngology
Meeting, the face nerve disease committee are recommended, and the evaluation criterion as face nerve functional rehabilitation uses.
I grades: function is normal；Facial all areas function is normal；It is equivalent to facial function 100%.
II grade: slight dysfunction；It is overall: to perceive slight facial muscle inability when examining, can have very slight
Synkinesia.Static symmetric and tension are normal, the good movement more than volume moderate when movement, and eye is micro- firmly can be completely closed,
Micro- asymmetry fond of food that is not salty；It is equivalent to facial function 76-99%.
III grade: moderate dysfunction；Overall two sides difference is obvious, but lossless face, perceives not serious associated
Movement, contracture and (or) hemifacial spasm；Symmetry and tension are normal when static.Move the mild to moderate movement of inch volume, ophthalmically acceptable power
Can completely it is closed, mouth with strength when slight force it is weak；It is equivalent to facial function 51-75%.
IV grade: middle severe dysfunction；Overall obvious powerless and (or) disfiguring asymmetry, static symmetric and tension are just
Often, volume without motion when movement, eye cannot be completely closed, mouth with strength when it is asymmetric；Facial function 26-50%.
V grade: severe dysfunction；The overall movement that can have just perceived；Static asymmetric, volume without motion when movement, eye is not
It can closed, micro- movement fond of food that is not salty completely；It is equivalent to facial function 1-25%.
VI grade: complete paralysis；Without any movement；Facial function 0%.
1.1.4 staging
In early days (acute stage): morbidity started to 15 days；
Mid-term (convalescence): 16 days to 6 months (morbidity half a month --- the related movement of facial muscle occurs)；
Advanced stage (linkage phase and spasm period): after morbidity 6 months (after the related movement of facial muscle occurs).
1.1.5 case is included in standard
(1) meet the tcm diagnosis standard and Western medicine diagnostic criteria of above-mentioned bell paralysis.
(2) male or female, the age is between 18-70 years old
(3) Informed choice voluntarily participates in this researcher after agreeing to.
(4) following exclusion criteria persons are not met simultaneously.
1.1.6 case exclusion criteria
(1) tcm diagnosis standard and Western medicine diagnostic criteria person are not met.
(2) there is Ipsilateral mastoidea pain, external auditory canal, auricle feel decline and external auditory canal, eardrum bleb (Hunt syndrome)
Person.
(3) person that is diagnosed as actue infectious polyradiculoneuritis.
(4) secondary to tympanitis, labyrinthitis, the otogenic facial paralysis of mastoiditis and parotitis, meningitis, rear cranium
Peripheral Facial Paralysis Patients caused by nest tumour, suppurative mandibular lymphnoditis.
(5) Traumatic Facial damages the wounded.
(6) severe infection or the bad person of hypertension, blood glucose control.
(7) merge the heart, the cerebrovascular or liver, kidney, lung and hemopoietic system or other systems serious disease or mental disease, puerperium
The patient of phase.
(8) other treatment has been received or has received, the index observer of this research may be influenced.
1.1.7 it rejects and the standard that falls off
(1) the peripheral facial paralysis person secondary to other diseases (such as tympanitis, tumour) is diagnosed as after being included in grouping.
(2) voluntarily bolter.
(3) because a variety of causes does not complete treatment and observer, as unfinished entire course of therapy person, observation of curative effect by regulation
Record imperfect person, not by the infull person of predetermined treatment or data.
(4) it falls off naturally in observation, person lost to follow-up.
(5) subject's compliance is poor, and the person that should not continue reception test.
1.2 general information
Whole selected cases 346, were hospitalized and outpatient from 2008~2016 Gansu Provincial Hospital of Traditional Chinese Medicine, wherein
It rejects and falls off 19, totally 327 complete entire research process, and patient is divided into treatment group 167, control group 160 at random
Example, two groups of patient's ordinary circumstances are relatively shown in Table 1~5.
Table 1-5 is shown: the totally classification, the disabled index of face of two groups of Genders, age, the course of disease, H-B grading scale
(FDI) scale score, no significant difference (P> 0.05), it is comparable.
2. test method
2.1 treatment method
Control group: oral strong pine 30mg 1 time/d, continuous 7 days, was then gradually reduced at 7-10 days；Take orally compound dimension life
Plain B2 piece, 3 times/d；Intramuscular injection vitamin B12, 500ug, 1 time/d；Chloromycetin eyedrops, daily eye drip for several times, with shielding angle
Film.
Treatment group: there is the granular preparation of prescription preparation of the present invention；Usage and dosage: it 15g/ times, 3 times/day, takes after mixing it with water.2 groups with
10 days are 1 course for the treatment of, 2~6 course for the treatment of of general treatment.
2.2 observation index and method
2.2.1 safety observations
(1) general physical examination project；
(2) blood, urine, feces are conventional, biochemical conventional, ECG examination in test into group when inspection, to exclude severe primary
Disease.Adverse drug reaction is recorded simultaneously.
2.2.2 electrophysiological index
Electromyography (EMG): orbicular muscle of eye, the mouth wheel circle of strong side and Ipsilateral are detected respectively using same core round needle electrode
Flesh, waveform, time limit, wave amplitude and the maximum of motor unit potential when observing spontaneous potential when being inserted into current potential, muscular relaxation and gently exerting oneself
Current potential is raised when firmly shrinking.
2.2.3 efficacy evaluation
(1) House-Brackmann facial nerve function totality grading scale.
(2) facioplegia grading grade form: improving this table by the symptom and sign of observing pretherapy and post-treatment patient,
And analysis is compared to the scoring of each group patient variation.
(3) disabled index (FDI) scale of face: it is divided into somatic function and social life function two parts, according in scale
The problem of proposition, carries out disabled degree and curative effect by the variation of the body and socio-psychology-status of patient's facial nerve disease
Evaluation.FDI scale shares 10 problems, 1 ~ 5 reflection somatic function (FDIP), 6 ~ 10 reflection social life functions
On facial neurological dysfunction and thus (FDIS), the table is simple and easy to do, and bring social mentality influences to carry out thoroughly evaluating,
It is of great significance in terms of therapeutic evaluation.
2.3 efficacy assessment standard
Efficacy of Traditional Chinese Medicine evaluation criteria etc. is worked out " peripheral using Professional Committee, Chinese Association of Chinese and Western Medicine neurology department
The combination of Chinese tradiational and Western medicine evaluation of facioplegia and criterion of therapeutical effect (draft) " it is evaluated.
Recovery from illness: I grade of HB scale；The scoring of facioplegia grading is 100 points.
It is effective: II grade of HB scale；Facioplegia grading scoring 75 points or more, it is 100 points less than.
It is effective: III grade of HB scale；Facioplegia grading scores at 75 points or less, 50 points or more.
It is invalid: IV grade of HB scale and following；Facioplegia grading scores 50 points and less.
2.4 statistical method
Data processing is carried out using SPSS13.0 software, normal distribution data results use mean ± standard deviation (± s) table
Show, skewness data results are indicated using median (interquartile range) M (Q).Quantitative data is examined using t and rank sum test,
Qualitative data uses χ2Inspection and rank sum test.P< 0.05(bilateral) think that difference is statistically significant.
3 results
The classification of 3.1 curative effect marking scales is compared
3.1.1House-Brackmann facial nerve function totally compare by classification
Table 6 shows that totally classification is poor compared with before treatment for House-Brackmann facial nerve function after treatment group's treatment
It is different it is statistically significant (P< 0.01), illustrate to make moderate progress before treating the relatively treatment of rear face nervous function.
Table 7 shows that totally classification is poor compared with before treatment for House-Brackmann facial nerve function after control group treatment
It is different it is statistically significant (P< 0.01), illustrate to make moderate progress before treating the relatively treatment of rear face nervous function.
Table 8 shows that two groups of patient House-Brackmann facial nerve functions totally compare by classification after treatment, and difference has system
Meter meaning (P< 0.01), illustrate that treatment group improves facial nerve function better than control group.
3.1.2 facioplegia grading scoring is compared
Table 9 shows that the facioplegia degree of every symptom makes moderate progress before relatively treating after treatment group's treatment, and difference is equal
Statistically significant (P< 0.01).
Table 10 shows that the facioplegia degree of every symptom makes moderate progress before relatively treating after control group treatment, difference
Statistically significant (P< 0.01).
Table 11 shows that the facioplegia degree scoring of two groups of patient's individual event symptoms is compared after treatment, and difference is without statistics
Meaning (P> 0.05).
Table 12 shows that two groups of patient's treatments increase before neural paralysis grading total score is relatively treated below, difference
Statistically significant (P< 0.01)；Neural paralysis grading total score treatment group is higher than control group below for treatment, and difference has statistics
Meaning (P< 0.01).The degree that prompt treatment group improves facial nerve function is substantially better than control group.
3.1.3 (± S) is compared in disabled index (FDI) scoring of face
Table 13 shows that two groups of patients treat before rear quarters body function total score is relatively treated and increase, and difference has statistics meaning
Justice (P< 0.01)；Treat rear quarters body function total score treatment group be higher than control group, difference it is statistically significant (P< 0.01).
Table 14 shows that social function total score increases before relatively treating after two groups of patient's treatments, and difference has statistics meaning
Justice (P< 0.01)；After treatment social function total score treatment group be higher than control group, difference it is statistically significant (P< 0.01).
Two groups of patient's electromyogram (ENG) results compare after 3.2 treatments
Table 15 shows that treatment group EMG restores normal person 57.36% after treatment, and control group 42.63%, two groups are compared, and difference has
Statistical significance (P< 0.01).
3.3 curative effects compare
3.3.1 two groups of patient's curative effects compare
The display of table 16, treatment group's cure rate 58.68%, obvious effective rate 26.95%, control group cure rate 40.62%, obvious effective rate
25.62%, curative effect compares between two groups, difference it is statistically significant (P< 0.01).Treatment group's total effective rate is higher than control group, difference
Statistically significant (P< 0.05).
3.3.2 different patient's curative effects by stages compare
Table 17 show, treatment group's early stage, mid-term, patients with terminal cure rate be respectively 66.27%, 49.02%, 57.58%,
Curative effect between three groups compares, difference it is statistically significant (P< 0.05).
Table 18 show, control group early stage, mid-term, patients with terminal cure rate be respectively 56.18%, 38.60%, 15.91%,
Curative effect between three groups compares, difference it is statistically significant (P< 0.01).
Table 19 is shown, in early days with patients with terminal treatment group compared with control group curative effect, no significant difference (P>
0.05)；Treatment group's patients with terminal cure rate 57.58%, obvious effective rate 24.24%, it is control group patients with terminal cure rate 17.65%, effective
Rate 14.71%, two groups of patient's curative effects compare, difference it is statistically significant (P< 0.01).Show treatment group to patients with terminal curative effect
Better than control group.
3.4 safety observations
Two groups of patients are showed no adverse reaction before and after treatment.Pretherapy and post-treatment blood, urine, feces are conventional, biochemistry is conventional, electrocardiogram is equal
It shows no obvious abnormalities.
Above-mentioned clinical data shows that totally classification is poor compared with before treatment for H-B face nerve function after two groups of patient's treatments
It is different it is statistically significant (P< 0.01), illustrate two kinds of therapies to all improvement of the face nerve function of patient.Treatment group
Treating rear H-B classification to reach I grade and II patient is 64.47% and 29.34%, and H-B classification reaches I grade and II after control group treatment
Patient be 43.13% and 25.63%, two groups are compared, difference it is statistically significant (P< 0.01), illustrate that treatment group improves patient
Facial nerve function is substantially better than control group, shows that a kind of composition for treating bell paralysis can effectively improve facial paralysis trouble
The facial nerve function of person.
Clinical data also shows, the facioplegia degree scoring of two groups of patients each individual event symptom before and after treatment is compared, poor
It is different it is statistically significant (P< 0.01), before two groups of patient's facioplegia grading total scores are relatively treated after treatment
Improve, difference it is statistically significant (P< 0.01), illustrate that two kinds of therapies can effectively improve every facioplegia symptom, such as
Nasolabial groove shoals, palpebral fissure asymmetry etc., while the recovery for the adjoint sensory disturbance such as promote hypercacusis, hypogeusia, thus
Improve entire facial nerve function on the whole, reduces influence of the facial paralysis to daily life and social life, nerve is numb below for treatment
Numbness grading total score treatment group be higher than control group, difference it is statistically significant (P< 0.01).Illustrate that treatment group improves facial nerve
The degree of paralysis is better than control group, shows that a kind of composition for treating bell paralysis can effectively improve facial paralysis patient's
Facioplegia symptom.
Clinical data shows that the normal person's (60.45%) for the treatment of group EMG recovery is higher than control group (41.53%) after treatment, two groups
Compare, difference have statistical difference (P< 0.01).Show that a kind of composition for treating bell paralysis promotes facial paralysis to suffer from
The recovery of person's facial muscle muscular strength.
Clinical data shows, treatment group's cure rate 58.68%, obvious effective rate 26.95%, control group cure rate 40.62%, effective
Rate 25.62%, curative effect compares between two groups, difference it is statistically significant (P< 0.01).Treatment group's total effective rate is higher than control group, poor
It is different it is statistically significant (P< 0.05).Illustrate the curative effect for the treatment of group better than control group, shows a kind of to treat idiopathic facial fiber crops
The composition treatment bell paralysis of numbness has significant clinical efficacy.
Different patient's curative effects by stages compare, treatment group's early stage, mid-term, patients with terminal cure rate be 66.27%,
49.02%, 57.58%, the curative effect between three groups compares, difference it is statistically significant (P< 0.05).Control group early stage, mid-term, advanced stage
The cure rate of patient is respectively 60.76%, 42.55%, 17.65%, and the curative effect between three groups compares, difference it is statistically significant (P<
0.01).Illustrate to get over patient early treatment, can more obtain significant curative effect.
Two kinds of therapies compare early stage and mid-term patient's curative effect, no significant difference (P> 0.05), treatment group's advanced stage
Patient's cure rate 57.58%, obvious effective rate 24.24%, control group patients with terminal cure rate 17.65%, obvious effective rate 14.71%, two groups of trouble
Person's curative effect compares, difference it is statistically significant (P< 0.01)；Illustrate treatment group to the curative effect of patients with terminal better than control group, table
A kind of bright composition for treating bell paralysis also has significant curative effect to advanced refractory patient.
Specific embodiment
The prescription of Chinese materia medica preparation of the present invention and preparation are described further below by specific embodiment.
The preparation of embodiment 1, granule
Raw material proportioning: in parts by weight
45 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiong, 5 parts of scorpio, 5 parts of centipede, 10 parts of rhizoma typhonii, 10 parts of Rhizoma Et Radix Notopterygii, 20 parts of rhizoma polygonati, Radix Astragali 20
Part, 10 parts of thizoma curculiginis, 10 parts of HERBA EPIMEDII, 5 parts of Radix Glycyrrhizae.
Preparation process:
(1) scorpio, centipede in prescription are ground into fine powder, cross 80 meshes, it is spare；
(2) remaining all medicine adds water to cook 2 times, and merging filtrate when being concentrated into 1:1, is set in container and is cooled to room temperature, and second is added
Alcohol makes alcohol content up to 60%, stands 12 hours or more, recycles ethyl alcohol, is condensed into medicinal extract, specific gravity 1.18 at 20 DEG C, spare.
(3) medicinal extract is mixed with fine powder, is stirred evenly, adjusted humidity with 70% ethyl alcohol, softwood is made, pelletize, drying is whole
Grain, packing, 15g/ bags.
(4) quality examination, packing.
Usage and dosage: it 15g/ times, 3 times/day, takes after mixing it with water.10 days are 1 course for the treatment of.
The preparation of embodiment 2, capsule
Raw material proportioning: in parts by weight
40 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiong, 3 parts of scorpio, 3 parts of centipede, 6 parts of rhizoma typhonii, 6 parts of Rhizoma Et Radix Notopterygii, 15 parts of rhizoma polygonati, Radix Astragali 15
Part, 6 parts of thizoma curculiginis, 6 parts of HERBA EPIMEDII, 3 parts of Radix Glycyrrhizae.
(1) scorpio, centipede in prescription are ground into fine powder, cross 80 meshes, it is spare；
(2) remaining all medicine adds water to cook 2 times, and merging filtrate when being concentrated into 1:1, is set in container and is cooled to room temperature, and second is added
Alcohol makes alcohol content up to 60%, stands 12 hours or more, recycles ethyl alcohol, is condensed into medicinal extract, specific gravity 1.18 at 20 DEG C, spare;.
(3) medicinal extract is mixed with fine powder, is stirred evenly, adjusted humidity with 70% ethyl alcohol, softwood is made, pelletize, drying is whole
It is spare after grain；
(4) it dispenses: being placed on capsule filling machine and be packed as 0.5g/.1g is equivalent to crude drug 10g；
(5) it polishes, quality examination, packing.
Usage and dosage: it 8 tablets/time, 3 times/day, takes after mixing it with water.10 days are 1 course for the treatment of.
The preparation of embodiment 3, tablet
Raw material proportioning: in parts by weight
50 parts of Radix Angelicae Sinensis, 25 parts of Rhizoma Chuanxiong, 8 parts of scorpio, 8 parts of centipede, 12 parts of rhizoma typhonii, 12 parts of Rhizoma Et Radix Notopterygii, 22 parts of rhizoma polygonati, Radix Astragali 22
Part, 12 parts of thizoma curculiginis, 12 parts of HERBA EPIMEDII, 8 parts of Radix Glycyrrhizae.
Preparation process:
(1) scorpio, centipede in prescription are ground into fine powder, cross 80 meshes, it is spare；
(2) remaining all medicine adds water to cook 2 times, and merging filtrate when being concentrated into 1:1, is set in container and is cooled to room temperature, and second is added
Alcohol makes alcohol content up to 60%, stands 12 hours or more, recycles ethyl alcohol, is condensed into medicinal extract, specific gravity 1.18 at 20 DEG C, spare.
(3) medicinal extract is mixed with fine powder, is stirred evenly, adjusted humidity with 70% ethyl alcohol, softwood is made, pelletize, drying is whole
It is spare after grain；
(4) tabletting: being added a certain amount of magnesium stearate and superfine silica gel powder, is packed into tabletting machine, makes every sheet weight
0.5g；
(5) quality examination, packaging.
Usage and dosage: it 8-10 pieces/times, 3 times/day, takes after mixing it with water.10 days are 1 course for the treatment of.
The preparation of embodiment 4, pill
Raw material proportioning: in parts by weight
43 parts of Radix Angelicae Sinensis, 18 parts of Rhizoma Chuanxiong, 5 parts of scorpio, 5 parts of centipede, 8 parts of rhizoma typhonii, 8 parts of Rhizoma Et Radix Notopterygii, 18 parts of rhizoma polygonati, Radix Astragali 18
Part, 8 parts of thizoma curculiginis, 8 parts of HERBA EPIMEDII, 5 parts of Radix Glycyrrhizae.
Preparation process:
(1) scorpio, centipede in prescription are ground into fine powder, cross 80 meshes, it is spare；
(2) remaining all medicine adds water to cook 2 times, and merging filtrate when being concentrated into 1:1, is set in container and is cooled to room temperature, and second is added
Alcohol makes alcohol content up to 60%, stands 12 hours or more, recycles ethyl alcohol, is condensed into medicinal extract, specific gravity 1.18 at 20 DEG C, spare.
(3) drug and matrix mix: fine drug powder and medicinal extract being added in Macrogol 3000, heating is uniformly mixed, standby
With；
(4) dripping: choosing water-insoluble condensate liquid, and drug and matrix and condensate liquid are added in pill dripping machine, carries out dripping.
Every ball weight is 0.25g；
(5) it cools down, washes ball, selects ball；
(6) quality examination, packaging.
Usage and dosage: it 16 tablets/time, 3 times/day, takes after mixing it with water.10 days are 1 course for the treatment of.
Embodiment 5, the soft preparation by wafer
Raw material proportioning: in parts by weight
47 parts of Radix Angelicae Sinensis, 22 parts of Rhizoma Chuanxiong, 6 parts of scorpio, 6 parts of centipede, 10 parts of rhizoma typhonii, 10 parts of Rhizoma Et Radix Notopterygii, 20 parts of rhizoma polygonati, Radix Astragali 20
Part, 10 parts of thizoma curculiginis, 10 parts of HERBA EPIMEDII, 8 parts of Radix Glycyrrhizae.
Scorpio, centipede in prescription are ground into fine powder by preparation process (1), cross 200 meshes, spare；
(2) remaining all medicine adds water to cook 2 times, and merging filtrate when being concentrated into 1:1, is set in container and is cooled to room temperature, and second is added
Alcohol makes alcohol content up to 60%, stands 12 hours or more, recycles ethyl alcohol, is condensed into medicinal extract, specific gravity 1.18 at 20 DEG C, spare.
(3) dry: medicinal extract to be placed in drying in microwave dryer, crushed after being dried crosses 200 meshes, and drug is thin with crushing
Powder is uniformly mixed, spare；
(4) medicinal powder is mixed with matrix: it takes medicinal powder to be added in soybean oil, mixes well, medicinal powder and soybean oil ratio are 0.5:
1.It is added a certain amount of wetting agent, suspension is spare after glidant；
(5) it pelletizes: the drug of mixing and matrix being placed in encapsulating machine, pelletized, every weight 0.5g；
(6) quality examination, packaging.
Usage and dosage: it 16 tablets/time, 3 times/day, takes after mixing it with water.10 days are 1 course for the treatment of.
Claims (4)
1. a kind of for treating the Chinese materia medica preparation of bell paralysis, be with Radix Angelicae Sinensis, Rhizoma Chuanxiong, scorpio, centipede, rhizoma typhonii,
Rhizoma Et Radix Notopterygii, rhizoma polygonati, Radix Astragali, thizoma curculiginis, HERBA EPIMEDII, Radix Glycyrrhizae are bulk pharmaceutical chemicals, are prepared into according to the common process and auxiliary material of pharmacy of Chinese materia medica
Oral preparations；Each raw material is matched by following parts by weight:
40-50 parts of Radix Angelicae Sinensis, 15-25 parts of Rhizoma Chuanxiong, 3-8 parts of scorpio, 3-8 parts of centipede, 6-12 parts of rhizoma typhonii, 6-12 parts of Rhizoma Et Radix Notopterygii, rhizoma polygonati
15-22 parts, 15-22 parts of Radix Astragali, 6-12 parts of thizoma curculiginis, 6-12 parts of HERBA EPIMEDII, 3-8 parts of Radix Glycyrrhizae.
2. a kind of for treating the Chinese materia medica preparation of bell paralysis as described in claim 1, it is characterised in that: each raw material
It is matched by following parts by weight:
43-47 parts of Radix Angelicae Sinensis, 18-22 parts of Rhizoma Chuanxiong, 5-6 parts of scorpio, 5-6 parts of centipede, 8-10 parts of rhizoma typhonii, 8-10 parts of Rhizoma Et Radix Notopterygii, rhizoma polygonati
18-20 parts, 18-20 parts of Radix Astragali, 8-10 parts of thizoma curculiginis, 8-10 parts of HERBA EPIMEDII, 5-8 parts of Radix Glycyrrhizae.
3. a kind of for treating the Chinese materia medica preparation of bell paralysis as described in claim 1, it is characterised in that: each raw material
It is matched by following parts by weight:
45 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Chuanxiong, 5 parts of scorpio, 5 parts of centipede, 10 parts of rhizoma typhonii, 10 parts of Rhizoma Et Radix Notopterygii, 20 parts of rhizoma polygonati, 20 parts of Radix Astragali,
10 parts of thizoma curculiginis, 10 parts of HERBA EPIMEDII, 5 parts of Radix Glycyrrhizae.
4. a kind of for treating the Chinese materia medica preparation of bell paralysis as described in claim 1, it is characterised in that: in described
Formulation is capsule, granule, tablet, pill.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340350A (en) * | 2000-08-26 | 2002-03-20 | 甘肃省中医院 | Chewing medicine for treating facial paralysis and its preparing process |
| CN101549119A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for treating idiopathic facial palsy |
| CN103393863A (en) * | 2013-08-14 | 2013-11-20 | 河南中医学院 | Traditional Chinese medicine for treating peripheral facial paralysis |
-
2016
- 2016-08-31 CN CN201610782582.2A patent/CN106177446B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340350A (en) * | 2000-08-26 | 2002-03-20 | 甘肃省中医院 | Chewing medicine for treating facial paralysis and its preparing process |
| CN101549119A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for treating idiopathic facial palsy |
| CN103393863A (en) * | 2013-08-14 | 2013-11-20 | 河南中医学院 | Traditional Chinese medicine for treating peripheral facial paralysis |
Non-Patent Citations (2)
| Title |
|---|
| 祛风颗粒治疗特发性面神经麻痹78例;周毓萍等;《西部中医药》;20131231;第26卷(第10期);81-83 |
| 祛风颗粒治疗特发性面神经麻痹78例;窦友义等;《中国中医药信息杂志》;20150131;第12卷(第1期);59 |
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