CN109432316A - For traditional Chinese medicine composition for herpes and preparation method thereof - Google Patents
For traditional Chinese medicine composition for herpes and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to one kind for traditional Chinese medicine composition for herpes and preparation method thereof, is made of following raw material components: 20 parts by weight of viola mandshurica, 15 parts by weight of dandelion, 20 parts by weight of honeysuckle, 15 parts by weight of Cortex Phellodendri, 15 parts by weight of rhizoma imperatae, 2 parts by weight of 15 parts by weight of isatis root, 20 parts by weight of Orostachys fimbriatus and borneol etc..Preparation method: weighing each raw material component in proportion, dry after cleaning, crushing；It is extracted later using steam distillation, filters and collect filtrate, be concentrated into paste, obtain Chinese medicine composition.Traditional Chinese medicine composition for herpes of the present invention selects the Chinese medicinal material containing active skull cap components, prescription proportion science, it is mild non-stimulated, safe without toxic side effect, it is flexible and convenient when use, it, can be effective for inhibiting and/or treating the diseases such as shingles zoster, pruitus, carbuncle boils boils, abscess with excellent activating blood circulation and reducing swelling, phencyclidine, anti-inflammatory anti-itch, clearing heat and detoxicating, putrefaction-removing granulation-promoting, detoxification dissipating bind and other effects.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to one kind for traditional Chinese medicine composition for herpes and its
Preparation method.
Background technique
It is well known that shingles zoster is the acute infection dermatoses as caused by varicella virus.To this virus
After the children of no immunity are infected, varicella occurs.Become carrier after some patientss are infected without symptom.Due to
Virus has neurotropism, can be hidden for a long time after infection in the neuron of spinal nerve posterior root ganglion, when lower for the resistance
Or when tired, infection, flu, virus can regrow breeding, and move to skin along nerve fibre, make the nerve invaded and skin
Skin generates strong inflammation.Fash generally has Unilateral and the characteristics of be distributed by nerve segment, is made of the bleb of cluster, and
With pain；Age is bigger, and neuralgia is heavier.
It is reported that: the crowd of institute's has age is likely to that shingles zoster can be obtained, and the acne although children can generally flood also has
Obtain shingles zoster.Usually, shingles zoster is easy in the elderly, women, 50 years old or more, hypoimmunity or defect, close
It " acts like a tyrant " on the person of phase over fatigue.In general, the age is bigger, and the state of an illness can be more serious, restores slower；Have immune
The patient of defect is easy to happen disseminated herpes zoster.
In addition, the treatment means of such disease are mostly based on doctor trained in Western medicine and physical therapy, treatment cycle is long, and pain is big costly, and
Side reaction is larger after Western medicine medication, mostly palliative；Traditional traditional Chinese medicine for oral administration also fears many patients, more because debating disease
It is incorrect and perverse trend is caused to be difficult to send out, add taste callus.Based on this, needs a kind of obvious effect and there is powerful applicability
Traditional Chinese medicine composition for herpes, to alleviate the pain of many patients.
Summary of the invention
For the defects in the prior art, the present invention is intended to provide it is a kind of for traditional Chinese medicine composition for herpes and
Preparation method.Traditional Chinese medicine composition for herpes of the present invention selects the Chinese medicinal material containing active skull cap components, prescription
Proportion science, mild non-stimulated, safe without toxic side effect, when use, are flexible and convenient, have excellent activating blood circulation and reducing swelling, enriching yin cool
Blood, anti-inflammatory anti-itch, clearing heat and detoxicating, putrefaction-removing granulation-promoting, detoxification dissipating bind and other effects, can effective for inhibit and/or treat shingles zoster,
The diseases such as pruitus, carbuncle boils boils, abscess.
For this purpose, the invention provides the following technical scheme:
In a first aspect, the present invention provides one kind for traditional Chinese medicine composition for herpes, raw material components are by weight
Meter, comprising: 10~30 parts by weight of viola mandshurica, 5~25 parts by weight of dandelion, 10~50 parts by weight of honeysuckle, Cortex Phellodendri 10~30
Parts by weight, 5~30 parts by weight of 5~20 parts by weight of rhizoma imperatae, 5~20 parts by weight of isatis root and Orostachys fimbriatus.
Preferably, raw material components further include: 1~5 weight of 0.1~3 parts by weight of borneol, 5~20 parts by weight of menthol and radix scutellariae
Measure part.
Preferably, it is made of following raw material components: 20 parts by weight of viola mandshurica, 15 parts by weight of dandelion, 20 weight of honeysuckle
Measure part, 15 parts by weight of Cortex Phellodendri, 15 parts by weight of rhizoma imperatae, 15 parts by weight of isatis root, 20 parts by weight of Orostachys fimbriatus, 2 parts by weight of borneol, peppermint
1 parts by weight of 5 parts by weight of brain and radix scutellariae.
Preferably, it is made of following raw material components: 10 parts by weight of viola mandshurica, 25 parts by weight of dandelion, 10 weight of honeysuckle
Measure part, 30 parts by weight of Cortex Phellodendri, 5 parts by weight of rhizoma imperatae, 20 parts by weight of isatis root, 5 parts by weight of Orostachys fimbriatus, 0.1 parts by weight of borneol, peppermint
5 parts by weight of 20 parts by weight of brain and radix scutellariae.
Preferably, it is made of following raw material components: 30 parts by weight of viola mandshurica, 5 parts by weight of dandelion, 50 weight of honeysuckle
Part, 10 parts by weight of Cortex Phellodendri, 20 parts by weight of rhizoma imperatae, 5 parts by weight of isatis root, 30 parts by weight of Orostachys fimbriatus, 3 parts by weight of borneol, menthol 5
3 parts by weight of parts by weight and radix scutellariae.
It should be noted that each bulk pharmaceutical chemicals of preparation the traditional chinese medicine composition of the invention are matched according to parts by weight, producing
When can according to corresponding ratio increase or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production
Can in grams, weight can increase or reduce, but the bulk pharmaceutical chemicals quality proportioning constant rate between each composition.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition, comprising the following steps: S1: claim in proportion
Each raw material component is taken, it is dry after cleaning, crushing；S2: each raw material component after drying is extracted using steam distillation,
Filtrate is filtered and collected later, obtains Chinese medicine composition.
Preferably, further includes: the filtrate for obtaining S2 to paste.
Preferably, in S1, each raw material component is crushed to 60~200 mesh.
Preferably, in S2, the extraction time of steam distillation is 50~100min, and the additional amount of water is raw material components
3~8 times of gross mass.
The third aspect, Chinese medicine composition provided by the invention preparation treatment shingles zoster, pruitus, carbuncle boils boils,
The drug of abscess and/or the application in medicated premix.Specifically, Chinese medicine composition of the invention is applied to affected part, preferably
Daily 1~2 time, and ten days as a treatment course, so as to effectively cure shingles zoster.
The above technical solution of the present invention has the following advantages over the prior art:
(1) applicant has found by numerous studies: traditional Chinese medicine composition for herpes of the present invention is selected containing natural
The Chinese medicinal material of active constituent, prescription proportion science, mild non-stimulated, safe without toxic side effect, when use, are flexible and convenient, have
Excellent activating blood circulation and reducing swelling, phencyclidine, anti-inflammatory anti-itch, clearing heat and detoxicating, putrefaction-removing granulation-promoting, detoxification dissipating bind and other effects, can be effective for
Inhibit and/or treat the diseases such as shingles zoster, pruitus, carbuncle boils boils, abscess.
(2) preparation method provided by the invention is used, the same of each bulk pharmaceutical chemicals active constituent can retained to greatest extent
When, the effective component in each raw medicinal material can sufficiently be released, to make the Chinese medicine composition being finally prepared not
Only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for curing various diseases.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Ground illustrates technical solution of the present invention, therefore is only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following embodiment, is all provided with
Three repeated experiments are set, data are the average value or mean+SD of three repeated experiments.
Viola mandshurica as used in the following examples, dandelion, honeysuckle, Cortex Phellodendri, rhizoma imperatae, isatis root, borneol, Orostachys fimbriatus
Meet the pertinent regulations under each medicinal material item of " Chinese Pharmacopoeia " text.Before feeding intake, by identification, ingredients material object and title phase
Symbol, quality comply with standard.
The present invention provides one kind for traditional Chinese medicine composition for herpes, and raw material components are by weight, comprising: purple
Flower 10~30 parts by weight of Chinese violet, 5~25 parts by weight of dandelion, 10~50 parts by weight of honeysuckle, 10~30 parts by weight of Cortex Phellodendri, cogongrass
5~30 parts by weight of 5~20 parts by weight of root, 5~20 parts by weight of isatis root and Orostachys fimbriatus；And it is also preferable to include borneols 0.1 for raw material components
1~5 parts by weight of~3 parts by weight, 5~20 parts by weight of menthol and radix scutellariae.
In addition, being directed to above-mentioned Chinese medicine composition, applicant specially devises preparation method, comprising the following steps:
S1: weighing each raw material component in proportion, cleans, is crushed to 60~200 mesh, dries later.
S2: each raw material component after drying is extracted using steam distillation, filters and collect filtrate later, will
The filtrate that S2 is obtained obtains Chinese medicine composition to paste.Wherein, the extraction time of steam distillation is 50~100min, and water
Additional amount be 3~8 times of raw material components gross mass.
It is illustrated With reference to embodiment:
Embodiment one
The present embodiment provides one kind to be used for traditional Chinese medicine composition for herpes, is prepared by following raw material components:
20 parts by weight of viola mandshurica, 15 parts by weight of dandelion, 20 parts by weight of honeysuckle, 15 parts by weight of Cortex Phellodendri, 15 parts by weight of rhizoma imperatae, plate
Blue 15 parts by weight of root and 20 parts by weight of Orostachys fimbriatus.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 100 mesh, dries later.
S2: each raw material component after drying is extracted using steam distillation, filters and collect filtrate later, will
The filtrate that S2 is obtained obtains Chinese medicine composition to paste.Wherein, the extraction time of steam distillation is 80min, and the addition of water
Amount is 5 times of raw material components gross mass.
Embodiment two
The present embodiment provides one kind to be used for traditional Chinese medicine composition for herpes, is prepared by following raw material components:
20 parts by weight of viola mandshurica, 15 parts by weight of dandelion, 20 parts by weight of honeysuckle, 15 parts by weight of Cortex Phellodendri, 15 parts by weight of rhizoma imperatae, plate
Blue 15 parts by weight of root, 20 parts by weight of Orostachys fimbriatus, 1 parts by weight of 2 parts by weight of borneol, 5 parts by weight of menthol and radix scutellariae.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 100 mesh, dries later.
S2: each raw material component after drying is extracted using steam distillation, filters and collect filtrate later, will
The filtrate that S2 is obtained obtains Chinese medicine composition to paste.Wherein, the extraction time of steam distillation is 80min, and the addition of water
Amount is 5 times of raw material components gross mass.
Embodiment three
The present embodiment provides one kind to be used for traditional Chinese medicine composition for herpes, is prepared by following raw material components:
10 parts by weight of viola mandshurica, 25 parts by weight of dandelion, 10 parts by weight of honeysuckle, 30 parts by weight of Cortex Phellodendri, 5 parts by weight of rhizoma imperatae, plate
Blue 20 parts by weight of root, 5 parts by weight of Orostachys fimbriatus, 5 parts by weight of 0.1 parts by weight of borneol, 20 parts by weight of menthol and radix scutellariae.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 200 mesh, dries later.
S2: each raw material component after drying is extracted using steam distillation, filters and collect filtrate later, will
The filtrate that S2 is obtained obtains Chinese medicine composition to paste.Wherein, the extraction time of steam distillation is 50min, and the addition of water
Amount is 3 times of raw material components gross mass.
Example IV
The present embodiment provides one kind to be used for traditional Chinese medicine composition for herpes, is prepared by following raw material components:
30 parts by weight of viola mandshurica, 5 parts by weight of dandelion, 50 parts by weight of honeysuckle, 10 parts by weight of Cortex Phellodendri, 20 parts by weight of rhizoma imperatae, plate
Blue 5 parts by weight of root, 30 parts by weight of Orostachys fimbriatus, 3 parts by weight of 3 parts by weight of borneol, 5 parts by weight of menthol and radix scutellariae.
By above-mentioned raw materials component, Chinese medicine composition of the invention is prepared:
S1: weighing each raw material component in proportion, cleans, is crushed to 60 mesh, dries later.
S2: each raw material component after drying is extracted using steam distillation, filters and collect filtrate later, will
The filtrate that S2 is obtained obtains Chinese medicine composition to paste.Wherein, the extraction time of steam distillation be 100min, and water plus
Enter 8 times that amount is raw material components gross mass.
In addition, the effect of in order to further evaluate each embodiment Chinese medicine composition, carry out following clinical trial:
Call-up age 18~60 years old Patients with Herpes Zoster 200 (male to female ratio 1:1).The Symptoms of patient are not
With degree papule miliary to soybean-sized, tufted distribution is without fusion or blister, and tonic vesicle wall is shinny, limpid vesicle fluid, outside
Week, skin was normal between each cluster blister group, the diseases such as the conscious burning heat sensation of pruitus, illing skin or neuralgia around with blush.Tool
Body, patient is divided into 4 groups, every group of 50 people try out the Chinese medicine composition of embodiment respectively.Detailed directions are as follows: cleaning skin
Afterwards, the Chinese medicine composition of 3~5g is taken to be applied to affected part.It continuously tries out Chinese medicine composition provided by the invention 10 days, records each trouble
The curative effect of person, specific data are as shown in table 1.
Observation of curative effect standard is divided into healing, effective and invalid；It cures: shingles zoster, pruitus, carbuncle boils boils, abscess
Etc. symptoms disappear, skin attenuate and acne print disappear；Effective: the symptoms such as shingles zoster, pruitus, carbuncle boils boils, abscess are obvious
Mitigate；It is invalid: to improve before and after the symptom treatments such as shingles zoster, pruitus, carbuncle boils boils, abscess unobvious.
The curative effect statistical form of each embodiment Patients with Herpes Zoster of table 1
| It cures | It is effective | In vain | |
| Embodiment one | 43 | 7 | 0 |
| Embodiment two | 49 | 1 | 0 |
| Embodiment three | 49 | 1 | 0 |
| Example IV | 48 | 2 | 0 |
Certainly, the case where being enumerated in addition to embodiment one to example IV, the type and weight percent of other raw material components,
Condition and parameter in preparation process etc. are also possible.
Traditional Chinese medicine composition for herpes of the present invention selects the Chinese medicinal material containing active skull cap components, prescription proportion
Science, mild non-stimulated, safe without toxic side effect, when use, are flexible and convenient, have excellent activating blood circulation and reducing swelling, phencyclidine, disappear
Scorching antipruritic, clearing heat and detoxicating, putrefaction-removing granulation-promoting, detoxification dissipating bind and other effects, can be effective for inhibiting and/or treating shingles zoster, skin
The diseases such as itch, carbuncle boils boils, abscess.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (10)
1. one kind is used for traditional Chinese medicine composition for herpes, which is characterized in that raw material components are by weight, comprising:
10~30 parts by weight of viola mandshurica, 5~25 parts by weight of dandelion, 10~50 parts by weight of honeysuckle, 10~30 weight of Cortex Phellodendri
Part, 5~30 parts by weight of 5~20 parts by weight of rhizoma imperatae, 5~20 parts by weight of isatis root and Orostachys fimbriatus.
2. according to claim 1 be used for traditional Chinese medicine composition for herpes, which is characterized in that further include:
1~5 parts by weight of 0.1~3 parts by weight of borneol, 5~20 parts by weight of menthol and radix scutellariae.
3. according to claim 2 be used for traditional Chinese medicine composition for herpes, which is characterized in that by following raw material groups
Divide and be made:
20 parts by weight of viola mandshurica, 15 parts by weight of dandelion, 20 parts by weight of honeysuckle, 15 parts by weight of Cortex Phellodendri, 15 weight of rhizoma imperatae
Part, 15 parts by weight of isatis root, 20 parts by weight of Orostachys fimbriatus, 1 parts by weight of 2 parts by weight of borneol, 5 parts by weight of menthol and radix scutellariae.
4. according to claim 2 be used for traditional Chinese medicine composition for herpes, which is characterized in that by following raw material groups
Divide and be made:
10 parts by weight of viola mandshurica, 25 parts by weight of dandelion, 10 parts by weight of honeysuckle, 30 parts by weight of Cortex Phellodendri, 5 weight of rhizoma imperatae
Part, 20 parts by weight of isatis root, 5 parts by weight of Orostachys fimbriatus, 5 parts by weight of 0.1 parts by weight of borneol, 20 parts by weight of menthol and radix scutellariae.
5. according to claim 2 be used for traditional Chinese medicine composition for herpes, which is characterized in that by following raw material groups
Divide and be made:
30 parts by weight of viola mandshurica, 5 parts by weight of dandelion, 50 parts by weight of honeysuckle, 10 parts by weight of Cortex Phellodendri, 20 weight of rhizoma imperatae
Part, 5 parts by weight of isatis root, 30 parts by weight of Orostachys fimbriatus, 3 parts by weight of 3 parts by weight of borneol, 5 parts by weight of menthol and radix scutellariae.
6. the preparation method of any one of Claims 1 to 5 Chinese medicine composition, which comprises the following steps:
S1: weighing each raw material component in proportion, dry after cleaning, crushing；
S2: each raw material component after the drying is extracted using steam distillation, is filtered and is collected filtrate later, obtain
To the Chinese medicine composition.
7. the preparation method of Chinese medicine composition according to claim 6, which is characterized in that further include:
The filtrate that the S2 is obtained is to paste.
8. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that:
In the S1, each raw material component is crushed to 60~200 mesh.
9. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that:
In the S2, the extraction time of the steam distillation is 50~100min, and the additional amount of water is that raw material components are total
3~8 times of quality.
10. any one of Claims 1 to 5 Chinese medicine composition preparation treatment shingles zoster, pruitus, carbuncle boils boils,
The drug of abscess and/or the application in medicated premix.
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| CN201811510149.9A CN109432316A (en) | 2018-12-11 | 2018-12-11 | For traditional Chinese medicine composition for herpes and preparation method thereof |
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| CN110974912A (en) * | 2019-12-31 | 2020-04-10 | 云南康旭生物科技有限公司 | Gel composition for treating uterine inflammation and preparation method thereof |
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| CN101390994A (en) * | 2008-10-23 | 2009-03-25 | 蒋月芳 | Medicine for treating herpes zoster |
| CN102357155A (en) * | 2011-10-27 | 2012-02-22 | 潘根起 | Traditional Chinese medicine combination for treating herpes zoster |
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| CN110974912A (en) * | 2019-12-31 | 2020-04-10 | 云南康旭生物科技有限公司 | Gel composition for treating uterine inflammation and preparation method thereof |
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