CN105477439A - Traditional Chinese medicine preparation for treating simplex type blood-heat type anaphylaxis purpura - Google Patents

Traditional Chinese medicine preparation for treating simplex type blood-heat type anaphylaxis purpura Download PDF

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CN105477439A
CN105477439A CN201610065568.0A CN201610065568A CN105477439A CN 105477439 A CN105477439 A CN 105477439A CN 201610065568 A CN201610065568 A CN 201610065568A CN 105477439 A CN105477439 A CN 105477439A
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grams
parts
radix
chinese medicine
medicine preparation
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周爱妍
杨晓梅
孟云芳
王雷
李安英
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating simplex type blood-heat type anaphylaxis purpura. The traditional Chinese medicine preparation is prepared from, by weight, 30 parts of roots of rehmannia, 25 parts of peony bark, 15 parts of thorn pear roots, 20 parts of radix paeoniae rubra, 25 parts of eleocharis dulcis, 20 parts of indigo naturalis, 15 parts of wintergreen, 30 parts of lalang grass rhizomes, 15 parts of lithospermum, 15 parts of caulis bambusae in taeniam, 15 parts of carbonized sanguisorba roots, 20 parts of scutellaria baicalensis, 15 parts of bletilla striata, 20 parts of fructus forsythia, 30 parts of gentiana triflora an 25 parts of liquorice. The preparation method includes the steps that water is added to the materials for being decocted twice, filtrate is concentrated, dried and put into capsules, and the traditional Chinese medicine preparation is obtained. Three to five particles of the traditional Chinese medicine preparation is orally taken twice a day when being used for treatment, and seven days constitute a treatment course. The traditional Chinese medicine preparation mainly achieves the effects of removing heat to cool blood, eliminating stasis to remove speckles and nourishing yin to produce body fluid, meanwhile can adjust immunity, has the effects of resisting to inflammation and calming and resisting to irritability, can obviously relieve the anaphylactic reaction caused by histamine and is definite in curative effect, less in concurrent purpura nephritis, less is side effect, safe and convenient.

Description

A kind of Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura, belong to technical field of Chinese medicines.
Background technology
Anaphylactoid purpura, also known as Henoch-Schonlein purpura, is a kind of allergic angiitis of invading skin and the tiny tremulous pulse of other organs and blood capillary, often accompany stomachache, arthralgia and renal damage, but platelet does not reduce.Be apt to occur in Children and teenager, start to have heating, headache, arthralgia, general malaise etc.Skin lesion shows as syringe needle to Semen Glycines size petechia, ecchymosis or urticaria sample erythra, and vesicle, blood blister can occur severe patient, even ulcer.Be apt to occur in extremity and stretch side, especially two lower limb and buttocks.Skin lesion is symmetrical, occurs in batch, easily recurs.Only have skin lesion person to claim simple purpura, with suffering from abdominal pain, suffering from diarrhoea, have blood in stool, even gastrointestinal hemorrhage person is called gastrointestinal type purpura; Schoenlein purpura is called with arthroncus, pain, even hydrarthrosis person; Companion hematuria, albuminuria, renal damage person is called renal purpura.
The treatment of primary disease; clinically except the elimination cause of disease; often apply Claritin, reduce the treatments such as vascular permeability medicine, anticoagulant medicine, adrenocortical hormone, immunosuppressant; but there is following defect: curative effect is not good enough; easy concurrent henoch Schonlein purpura nephritis; in application hormone therapy process, due to the impact of the factor such as body constitution and environmental change, often there will be bounce-back or aggravation phenomenon.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura, it has, and therapeutic effect is good, the advantage such as have no side effect.
The present invention is achieved by the following technical solutions:
Treating a Chinese medicine preparation for simple type blood-heat type anaphylactoid purpura, is be made up of the crude drug of following weight portion: 25 ~ 35 parts, the Radix Rehmanniae, Cortex Moutan 20 ~ 30 parts, Radix Rosae Normalis 10 ~ 20 parts, Radix Paeoniae Rubra 15 ~ 25 parts, black taro 20 ~ 30 parts, Indigo Naturalis 15 ~ 25 parts, Herba pyrolae japonicae 10 ~ 20 parts, Rhizoma Imperatae 25 ~ 35 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 20 parts, charred Radix Sanguisorbae 10 ~ 20 parts, Radix Scutellariae 15 ~ 25 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Fructus Forsythiae 15 ~ 25 parts, G. triflora 25 ~ 35 parts, 20 ~ 30 parts, Radix Glycyrrhizae.
Preferably, be made up of the crude drug of following weight portion: 30 parts, the Radix Rehmanniae, Cortex Moutan 25 parts, Radix Rosae Normalis 15 parts, Radix Paeoniae Rubra 20 parts, black taro 25 parts, Indigo Naturalis 20 parts, Herba pyrolae japonicae 15 parts, Rhizoma Imperatae 30 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Caulis Bambusae In Taenia 15 parts, charred Radix Sanguisorbae 15 parts, Radix Scutellariae 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Fructus Forsythiae 20 parts, G. triflora 30 parts, 25 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of described treatment simple type blood-heat type anaphylactoid purpura is: get each crude drug, mixing, add 10 times amount (weight multiple) water, decoct 2 ~ 3 hours, filter to get filtrate and filtering residue, in filtering residue, add 8 times amount (weight multiple) water, decoct 1.5 ~ 2.5 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste (relative proportion 1.34 ~ 1.40), vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
The Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura of the present invention, being applicable to children's's blood-heat type Simplex anaphylactoid purpura Chinese medical discrimination is injury of blood collaterals by heat card person.During treatment, oral, every day 2 times, each 3 ~ 5 (every content of dispersion 0.5 gram), 7 days courses for the treatment of, usual 1 ~ 2 course for the treatment of can cure.
Anaphylactoid purpura belongs to the traditional Chinese medical science " blood disorder " " purpura " " hematohidrosis " " hemorrhagic disease with purpura " category, how can not have under one's command caused by blood because pathogenic heat injure blood network, the absurd row of forcing blood or the deficiency of vital energy.Anaphylactoid purpura is clinical the most common with the absurd passerby of pathogenic heat forcing blood.Chinese medicine preparation of the present invention is based on clearing away heat and cooling blood, eliminating blood stasis and removing ecchymoses, YIN nourishing and the production of body fluid promoting, simultaneously can immunity moderation, there is antiinflammatory calm, anti-allergic effects, the anaphylaxis that histamine can be made to cause obviously alleviates, strengthening the body resistance, treatment anaphylactoid purpura determined curative effect, concurrent henoch Schonlein purpura nephritis is few, few side effects, safe ready.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1 prepares the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Formula is: 30 grams, the Radix Rehmanniae, Cortex Moutan 25 grams, Radix Rosae Normalis 15 grams, Radix Paeoniae Rubra 20 grams, black taro 25 grams, Indigo Naturalis 20 grams, Herba pyrolae japonicae 15 grams, Rhizoma Imperatae 30 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Caulis Bambusae In Taenia 15 grams, charred Radix Sanguisorbae 15 grams, Radix Scutellariae 20 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Fructus Forsythiae 20 grams, G. triflora 30 grams, 25 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, decoct 2.5 hours, filter to get filtrate and filtering residue, add 8 times amount (weight multiple) water in filtering residue, decoct 2 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste (relative proportion 1.35), vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
Said medicine, being applicable to children's's blood-heat type Simplex anaphylactoid purpura Chinese medical discrimination is injury of blood collaterals by heat card person.During treatment, oral, every day 2 times, each 3 ~ 5 (every content of dispersion 0.5 gram), 7 days courses for the treatment of, usual 1 ~ 2 course for the treatment of can cure.
Embodiment 2 prepares the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Formula is: 25 grams, the Radix Rehmanniae, Cortex Moutan 20 grams, Radix Rosae Normalis 20 grams, Radix Paeoniae Rubra 25 grams, black taro 20 grams, Indigo Naturalis 15 grams, Herba pyrolae japonicae 20 grams, Rhizoma Imperatae 35 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Caulis Bambusae In Taenia 10 grams, charred Radix Sanguisorbae 20 grams, Radix Scutellariae 25 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Fructus Forsythiae 15 grams, G. triflora 35 grams, 30 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, decoct 2 hours, filter to get filtrate and filtering residue, add 8 times amount (weight multiple) water in filtering residue, decoct 2 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste, vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
Embodiment 3 prepares the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Formula is: 35 grams, the Radix Rehmanniae, Cortex Moutan 30 grams, Radix Rosae Normalis 10 grams, Radix Paeoniae Rubra 15 grams, black taro 30 grams, Indigo Naturalis 25 grams, Herba pyrolae japonicae 10 grams, Rhizoma Imperatae 25 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Caulis Bambusae In Taenia 20 grams, charred Radix Sanguisorbae 10 grams, Radix Scutellariae 15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 grams, Fructus Forsythiae 25 grams, G. triflora 25 grams, 20 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, decoct 3 hours, filter to get filtrate and filtering residue, add 8 times amount (weight multiple) water in filtering residue, decoct 1.5 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste, vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
Embodiment 4 prepares the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Formula is: 28 grams, the Radix Rehmanniae, Cortex Moutan 28 grams, Radix Rosae Normalis 13 grams, Radix Paeoniae Rubra 20 grams, black taro 22 grams, Indigo Naturalis 23 grams, Herba pyrolae japonicae 14 grams, Rhizoma Imperatae 31 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Caulis Bambusae In Taenia 16 grams, Radix Sanguisorbae 18 grams, Radix Scutellariae 17 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 grams, Fructus Forsythiae 22 grams, G. triflora 30 grams, 24 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, decoct 2 hours, filter to get filtrate and filtering residue, add 8 times amount (weight multiple) water in filtering residue, decoct 2 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste, vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
Embodiment 5 prepares the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura
Formula is: 33 grams, the Radix Rehmanniae, Cortex Moutan 23 grams, Radix Rosae Normalis 15 grams, Radix Paeoniae Rubra 22 grams, black taro 26 grams, Indigo Naturalis 19 grams, Herba pyrolae japonicae 17 grams, Rhizoma Imperatae 26 grams, Radix Arnebiae (Radix Lithospermi) 18 grams, Caulis Bambusae In Taenia 13 grams, Radix Sanguisorbae 15 grams, Radix Scutellariae 22 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 16 grams, Fructus Forsythiae 18 grams, G. triflora 28 grams, 25 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, decoct 2.5 hours, filter to get filtrate and filtering residue, add 8 times amount (weight multiple) water in filtering residue, decoct 1.5 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste, vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
Clinical data:
(1) patient data: patient 83 example, is First episode, man 54 example, female 29 example, at 6 ~ 13 years old age, the course of disease 1 ~ 5 day, is simple type.
(2) therapeutic modality: patient takes medicine (every day twice, each 4, every content of dispersion 0.5 gram) prepared by embodiment 1, and treat 7 days was 1 course for the treatment of, and after 2 courses for the treatment of, observe and decide adds up curative effect.
(3) criterion of therapeutical effect: clinical symptoms and sign disappear completely, normally, drug withdrawal observes 3 months without recidivist for curing for renal function and uroscopy; Clinical symptoms and sign disappear, normal renal function, uroscopy urine protein (± ~+) or erythrocyte (± ~+) for effective; Clinical symptoms and sign disappear substantially, normal renal function, and uroscopy urine protein (+) or erythrocyte (+) are for taking a turn for the better; Invalid without transferring to well through treating 2 weeks all diseases.
(4) therapeutic outcome; Patient 83 example, cures 71 examples (85.5%), effective 6 examples, and take a turn for the better 3 examples, invalid 3 examples, total effective rate 96.4%.All patients are and find that there is concurrent nephritis.
Case is illustrated:
Case 1: patient Tan, female, 9 years old, there is purpura in front pair of lower limb, buttocks, color and luster is scarlet, erythra is intensive, needle point to Semen Glycines size, part be linked to be sheet.Give drug oral of the present invention (prepared by embodiment 1).After taking medicine 1 week, skin lesion obviously alleviates; After taking medicine 2 weeks, symptom and sign all disappears.Continue 1 week consolidate curative effect of taking medicine.Follow up a case by regular visits to half a year, have no recurrence.
Case 2: patient Tang so-and-so, man, 10 years old, extremity are loose the granular petechia of foxtail millet, and partial fusion is in blocks, and that touches is in the way.Without heating, without arthralgia, without stomachache.Mind is clear, lassitude, and extremity are dispersed in symmetry petechia, and lower limb are especially many, and bilateral bulbar conjunctiva is congested.Cardiopulmonary check without exception.Give drug oral of the present invention (prepared by embodiment 1), after treating one week, erythra goes down, and only two lower limb are shown in and are dispersed in remote hemorrhage point, and deflorescence after two weeks, routine blood test is normal.Continue to take two courses for the treatment of with consolidate curative effect.Follow up a case by regular visits to half a year, have no recurrence.

Claims (7)

1. treat the Chinese medicine preparation of simple type blood-heat type anaphylactoid purpura for one kind, it is characterized in that: be made up of the crude drug of following weight portion: 25 ~ 35 parts, the Radix Rehmanniae, Cortex Moutan 20 ~ 30 parts, Radix Rosae Normalis 10 ~ 20 parts, Radix Paeoniae Rubra 15 ~ 25 parts, black taro 20 ~ 30 parts, Indigo Naturalis 15 ~ 25 parts, Herba pyrolae japonicae 10 ~ 20 parts, Rhizoma Imperatae 25 ~ 35 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Caulis Bambusae In Taenia 10 ~ 20 parts, charred Radix Sanguisorbae 10 ~ 20 parts, Radix Scutellariae 15 ~ 25 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Fructus Forsythiae 15 ~ 25 parts, G. triflora 25 ~ 35 parts, 20 ~ 30 parts, Radix Glycyrrhizae.
2. the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura according to claim 1, is characterized in that: be made up of following crude drug: 30 parts, the Radix Rehmanniae, Cortex Moutan 25 parts, Radix Rosae Normalis 15 parts, Radix Paeoniae Rubra 20 parts, black taro 25 parts, Indigo Naturalis 20 parts, Herba pyrolae japonicae 15 parts, Rhizoma Imperatae 30 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Caulis Bambusae In Taenia 15 parts, charred Radix Sanguisorbae 15 parts, Radix Scutellariae 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Fructus Forsythiae 20 parts, G. triflora 30 parts, 25 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura according to claim 1, is characterized in that: be made up of following crude drug: 25 grams, the Radix Rehmanniae, Cortex Moutan 20 grams, Radix Rosae Normalis 20 grams, Radix Paeoniae Rubra 25 grams, black taro 20 grams, Indigo Naturalis 15 grams, Herba pyrolae japonicae 20 grams, Rhizoma Imperatae 35 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Caulis Bambusae In Taenia 10 grams, charred Radix Sanguisorbae 20 grams, Radix Scutellariae 25 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Fructus Forsythiae 15 grams, G. triflora 35 grams, 30 grams, Radix Glycyrrhizae.
4. the Chinese medicine preparation for the treatment of simple type blood-heat type anaphylactoid purpura according to claim 1, is characterized in that: be made up of following crude drug: 35 grams, the Radix Rehmanniae, Cortex Moutan 30 grams, Radix Rosae Normalis 10 grams, Radix Paeoniae Rubra 15 grams, black taro 30 grams, Indigo Naturalis 25 grams, Herba pyrolae japonicae 10 grams, Rhizoma Imperatae 25 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Caulis Bambusae In Taenia 20 grams, charred Radix Sanguisorbae 10 grams, Radix Scutellariae 15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 grams, Fructus Forsythiae 25 grams, G. triflora 25 grams, 20 grams, Radix Glycyrrhizae.
5. the Chinese medicine preparation for the treatment of anaphylactoid purpura according to claim 1, is characterized in that: be made up of following crude drug: 28 grams, the Radix Rehmanniae, Cortex Moutan 28 grams, Radix Rosae Normalis 13 grams, Radix Paeoniae Rubra 20 grams, black taro 22 grams, Indigo Naturalis 23 grams, Herba pyrolae japonicae 14 grams, Rhizoma Imperatae 31 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Caulis Bambusae In Taenia 16 grams, Radix Sanguisorbae 18 grams, Radix Scutellariae 17 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 13 grams, Fructus Forsythiae 22 grams, G. triflora 30 grams, 24 grams, Radix Glycyrrhizae.
6. the Chinese medicine preparation for the treatment of anaphylactoid purpura according to claim 1, is characterized in that: be made up of following crude drug: 33 grams, the Radix Rehmanniae, Cortex Moutan 23 grams, Radix Rosae Normalis 15 grams, Radix Paeoniae Rubra 22 grams, black taro 26 grams, Indigo Naturalis 19 grams, Herba pyrolae japonicae 17 grams, Rhizoma Imperatae 26 grams, Radix Arnebiae (Radix Lithospermi) 18 grams, Caulis Bambusae In Taenia 13 grams, Radix Sanguisorbae 15 grams, Radix Scutellariae 22 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 16 grams, Fructus Forsythiae 18 grams, G. triflora 28 grams, 25 grams, Radix Glycyrrhizae.
7. the preparation method of the Chinese medicine preparation of the treatment simple type blood-heat type anaphylactoid purpura according to any one of claim 1 ~ 6, it is characterized in that: get each crude drug, mixing, add 10 times amount (weight multiple) water, decoct 2 ~ 3 hours, filter to get filtrate and filtering residue, in filtering residue, add 8 times amount (weight multiple) water, decoct 1.5 ~ 2.5 hours, filter to get filtrate; Merge the filtrate of twice, be evaporated to thick paste, vacuum drying, pulverize, cross 80 mesh sieves, obtain extract medicated powder, incapsulate, to obtain final product.
CN201610065568.0A 2016-01-29 2016-01-29 Traditional Chinese medicine preparation for treating simplex type blood-heat type anaphylaxis purpura Pending CN105477439A (en)

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Application publication date: 20160413