CN103405649A - External pharmaceutical composition for recovery after nervus peroneus communis injury - Google Patents
External pharmaceutical composition for recovery after nervus peroneus communis injury Download PDFInfo
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- CN103405649A CN103405649A CN2013103601481A CN201310360148A CN103405649A CN 103405649 A CN103405649 A CN 103405649A CN 2013103601481 A CN2013103601481 A CN 2013103601481A CN 201310360148 A CN201310360148 A CN 201310360148A CN 103405649 A CN103405649 A CN 103405649A
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Abstract
invention is characterized by comprising the following active pharmaceutical ingredients in parts by weight: Solanum lyratum, rhizoma pleionis, schefflera arboricola, Herb of Paniculate Spotflower, securinega suffruticosa, mulberry seed, glossy privet fruit, immature bitter orange, Cassia alata, Glechoma longituba, Amblystegium serpens and Cladostachys amaranthoides. The clinical experiment proves that the invention has the characteristics of favorable curative effect and higher safety after nervus peroneus communis injury, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of externally-applied medicinal composition for rehabilitation after common peroneal nerve injury.
Background technology
Common peroneal nerve (the nervus peroneus communis) neck of fibula that detours place location tables is shallow, and be close to periosteum, therefore fracture of fibular neck or use fixation device can not involved at that time, cause the paralysis of shank extensor and cause drop foot, dorsiflexion of foot, the dysfunction of turning up occur, in being, turn down the deformity of hanging down.And stretch thumb, stretch apodization function and lose, be flexion, and before anterolateral crural and instep, inboard sensory disturbance.Reparation after common peroneal nerve injury is one of the difficult problem in Neurology Department field.The essence of neuranagenesis is that injured neurons forms new aixs cylinder, can rebuild synaptic contact with target organ, and recovers normal function.Wherein any one link goes wrong. all will affect the functional rehabilitation after common peroneal nerve injury.
The common peroneal nerve injury medicine of current clinical use has exogenous neurotrophic factor, adenylic acid Cycloxygenase activator and cyclic adenosine monophosphate, Protein kinase C, inflammatory factor, vitamin B complex etc.(the nerve growth factor of the nerve growth factor in exogenous neurotrophic factor wherein, NGF) curative effect is the most reliable, but also there is side effect in application NGF: sprouting of int normal neural axon can cause the untoward reaction such as chronic pain and abnormal neural reflex to occur.Therefore still need at present, explore the cheap medicine that a class can promote neural Fast Growth, can guarantee again regenerating nerve fiber function.
Chinese medicine after common peroneal nerve injury is circulation of qi promoting promoting blood circulation to remove obstruction in the collateral on the bases that are vigorate qi and replenish the blood more, but actual clinical effect not obvious.Acupuncture effect obviously is better than Chinese medicine, but the patient is difficult to adhere to.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little externally-applied medicinal composition for rehabilitation after common peroneal nerve injury of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of externally-applied medicinal composition for rehabilitation after common peroneal nerve injury is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Solani Lyratis, 6 ~ 12 parts of Pseudobulbus Cremastrae Seu Pleioness, 3 ~ 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 6 ~ 12 parts of Herba Spilanthis Acmellae, 3 ~ 10 parts of Cacumen Securinegae Suffruticosaes, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Fructus Ligustri Lucidi, 6 ~ 12 parts of Fructus Aurantii Immaturuss, 6 ~ 12 parts of Folium Cassiae Alataes, 1 ~ 5 part of HUOXUEDAN, 10 ~ 25 parts of 3 ~ 10 parts, nine layers wind of Folium Salicis Babylonicae moss.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Herba Solani Lyratis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 6 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Aurantii Immaturuss, 10 parts of Folium Cassiae Alataes, 2 parts of HUOXUEDAN, 20 parts of 6 parts, nine layers wind of Folium Salicis Babylonicae moss.
Wherein said: Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.But merit clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Pseudobulbus Cremastrae Seu Pleiones, be orchid Cremastra appendiculata Cremastra appendiculata (D.Don) Makino, pleione bulbocodioides Pleione bulbocodioides(Franch.) the dry pseudobulb of Rolfe or Pleione yunnanensis Pleione yunnanensis Rolfe.Sweet, the micro-suffering of nature and flavor, cold.Enter liver, stomach warp.But the merit heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), for Araliaceae Schefflera plant schefflera arboricola Scheffleva arboricola Hayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (Wight et Arn.) Harms, be used as medicine with stem and leaf.Nature and flavor are bitter, sweet, temperature.But merit pain relieving dissipating blood stasis, detumescence.
Herba Spilanthis Acmellae, be the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.But merit relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.
Cacumen Securinegae Suffruticosae, be euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse or the root of Rehd..Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.But merit expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, cold.GUIXIN, liver, kidney channel.The merit YIN nourishing of can enriching blood, promote the production of body fluid and moisturize.
Fructus Ligustri Lucidi, be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..The nature and flavor sweet, bitter, cold.Return liver, kidney channel.But the merit nourishing the liver and kidney, the improving eyesight black hair.
Fructus Aurantii Immaturus, be the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety or Fructus Citri sinensis Citrus sinensis Osbeck.But merit dispelling the stagnated QI intestinal stasis relieving.Nature and flavor are bitter, hot, sour, temperature.Return spleen, stomach warp.But merit dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm.
Folium Cassiae Alatae, for pulse family Folium Cassiae Alatae Cassia alata L., be used as medicine with leaf.The nature and flavor suffering, temperature.But the merit parasite killing is antipruritic.
HUOXUEDAN, be labiate HUOXUEDAN G.hederacea L.var .longituba Nakai; The herb of G.hederacea auct.non L..Bitter in the mouth; Hot; Cool in nature.Return liver; Gallbladder; Urinary bladder channel.But the merit dampness removing is treating stranguria; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.
The Folium Salicis Babylonicae moss, be Amblystegiaceae Folium Salicis Babylonicae moss Amblystegium serpens(Hedw.) plant of B.S.G..Nature and flavor are puckery; Flat.But merit astringing to arrest bleeding.
Nine layers of wind, be the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, invigorates blood circulation, and dredging collateral.
Composition principle: at present after the common peroneal nerve injury repairing and treating in the Neurology Department category Chinese medicine be circulation of qi promoting promoting blood circulation to remove obstruction in the collateral on the basis of vigorate qi and replenish the blood, but actual clinical effect not obvious more.Inventor's clinical research is for many years found, common peroneal nerve injury is except stagnation of QI blood stasis, after common peroneal nerve injury, the limbs channels is obstructed, to body fluid, stay poly-loose relevantly, surely belong to the traditional Chinese medical science and be referred to as " phlegm stagnating in meridian ", accumulation of phlegm blocks, in network, QI and blood is not all right, also can cause blood stasis, and " accumulation of blood is both of a specified duration, also can turn to expectorant water " (" treatise on blood trouble " volume five).So, because expectorant causes the stasis of blood, the long-pending stasis of blood is reduced phlegm, and phlegm and blood stasis, glue work are for suffering from, then obstructed till passages through which vital energy circulates, and four ends do not reach and produce the malnutrition in nerve distribution area territory.Therefore, after common peroneal nerve injury, main pathological basis is to be the accumulation of phlegm folder stasis of blood.Expectorant, the stasis of blood are pathological product, are again paathogenic factors; Being both the mark of disease, is also basis of disease, and the accumulation of phlegm of wherein especially take is main pathological factor.Therefore its treatment, should invigorate blood circulation, eliminate the phlegm, eliminating stagnation, dredging collateral go forward side by side, can promote local recovery after common peroneal nerve injury.
Compared with prior art, the present invention has following characteristics.
1, Herba Solani Lyrati and Pseudobulbus Cremastrae Seu Pleiones coordinate for monarch drug, wherein: but Herba Solani Lyrati merit clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, inventor's cell culture experiments proves: Herba Solani Lyrati decocting liquid is for having unique logical stagnant effect after the common peroneal nerve injury reparation, its mechanism of action may be that Herba Solani Lyrati can promote local growth associated protein (Growth associated protein-43, synthesizing GAP-43), and specific proteins GAP-43 is in the growth of nerve fiber, grow, axon regeneration and synaptic function the important role such as maintain, and the adjusting of participation neurotransmitter release, in neural growth again or regeneration, can determine and induce nervous process to grow along correct direction, and there is no a side effect of sprouting of that int normal neural axon of NGF, and the Pseudobulbus Cremastrae Seu Pleiones dispersing strength is strong, can strengthen the logical stagnant effect of Herba Solani Lyrati, reach the effect of eliminating the retardance of meridians accumulation of phlegm.We avoid using eliminating phlegm eliminating stagnation medicine, and its reason is that the meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, the nerve conduction irritability, easily cause the untoward reaction such as chronic pain and abnormal neural reflex.
2, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) pain relieving dissipating blood stasis for subsidence of swelling, the Herba Spilanthis Acmellae expelling wind and removing dampness, reducing swelling and alleviating pain, auxiliary Herba Solani Lyrati and Pseudobulbus Cremastrae Seu Pleiones are dispelled the phlegm-damp in meridians, remove long-pending this pathologic basis of wet retention of phlegm.
3, the Fructus Mori yin nourishing of enriching blood, the Fructus Ligustri Lucidi nourishing the liver and kidney, the Fructus Aurantii Immaturus dispelling the stagnated QI reduces phlegm, and from the phlegm-damp upstream and downstream, trains benefit respectively, helps Herba Solani Lyrati processed, Pseudobulbus Cremastrae Seu Pleiones, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Spilanthis Acmellae, and anti-its got rid of evils too and just hinders.
4, nine layers of wind promoting blood circulation to remove obstruction in the collateral of enriching blood, Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, the strong muscle of kidney tonifying, two flavor blood system medicines, return liver, kidney channel, reinforcement and elimination in combination, and the motionless blood of invigorating blood circulation, and the strong muscle effect of dredging collateral is arranged.
5, inventor's experimentation shows: low dose of HUOXUEDAN can increase the neurocyte liveness effectively.
6, Folium Cassiae Alatae can reduce our local skin stimulates, and is beneficial to the Drug Percutaneous Absorption rate.
7, in the loose dredging collateral medicine of one row, add low dose of Folium Salicis Babylonicae moss, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 6 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Aurantii Immaturuss, 10 parts of Folium Cassiae Alataes, 2 parts of HUOXUEDAN, 20 parts of 6 parts, nine layers wind of Folium Salicis Babylonicae moss.
The preparation method of embodiment 1 is: Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Spilanthis Acmellae, Cacumen Securinegae Suffruticosae, Fructus Mori, Fructus Ligustri Lucidi, Fructus Aurantii Immaturus, Folium Cassiae Alatae, HUOXUEDAN, Folium Salicis Babylonicae moss, nine layers of wind mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and concentrate drying dresses after pulverizing.
Embodiment 2, the crude drug weight proportion: 10 parts of Herba Solani Lyratis, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 3 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 6 parts of Herba Spilanthis Acmellae, 3 parts of Cacumen Securinegae Suffruticosaes, 6 parts of Fructus Mori, 6 parts of Fructus Ligustri Lucidi, 6 parts of Fructus Aurantii Immaturuss, 6 parts of Folium Cassiae Alataes, 1 part of HUOXUEDAN, 10 parts of 3 parts, nine layers wind of Folium Salicis Babylonicae moss.
Embodiment 3, the crude drug weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 6 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Aurantii Immaturuss, 10 parts of Folium Cassiae Alataes, 2 parts of HUOXUEDAN, 20 parts of 6 parts, nine layers wind of Folium Salicis Babylonicae moss.
Embodiment 4, the crude drug weight proportion: 30 parts of Herba Solani Lyratis, 12 parts of Pseudobulbus Cremastrae Seu Pleioness, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 12 parts of Herba Spilanthis Acmellae, 10 parts of Cacumen Securinegae Suffruticosaes, 12 parts of Fructus Mori, 12 parts of Fructus Ligustri Lucidi, 12 parts of Fructus Aurantii Immaturuss, 12 parts of Folium Cassiae Alataes, 5 parts of HUOXUEDAN, 25 parts of 10 parts, nine layers wind of Folium Salicis Babylonicae moss.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Cacumen Securinegae Suffruticosae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) HUOXUEDAN, Folium Salicis Babylonicae moss were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Herba Solani Lyrati, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Spilanthis Acmellae, Fructus Mori, Folium Cassiae Alatae, Fructus Aurantii Immaturus, nine layers of wind are decocted with water 2 times, filter, merging filtrate, be concentrated into relative density 1.1, obtains water extraction liquid;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added to the water extraction liquid of step 3 gained, stir, be concentrated into relative density 1.36.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Effective combination of said medicine, coordinate mutually, invigorates blood circulation, eliminates the phlegm, dredging collateral, effectively reach the purpose that promotes neural reparation after the common peroneal nerve injury treatment, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: compressing or the soft tissue contusion that accept for medical treatment year January in January, 2011 ~ 2013 cause common peroneal nerve injury 69 examples, and the common peroneal nerve crack conditions does not all appear in all patients.Male's 46 examples wherein, women's 23 examples, 14 ~ 67 years old age, average 27.9 years old.
1.1.2 grouping: be divided at random matched group 24 examples, dress group 22 examples, unguentum group 23 examples.Before three groups of patient treatments, compare on sex, age, the state of an illness, and the difference not statistically significant (P > 0.05), have comparability.
1.2 method.
1.2.1 administering mode: matched group takes conventional therapy and function to rebuild, capable plaster slab is fixed in case of necessity, dressing group adopts embodiment 1 gained medicament part to dress on the basis of matched group, the unguentum group adopts the local external application of embodiment 3 gained unguentum on the basis of matched group, dress group and unguentum group changed dressings once in every 3 days, after after treatment, 4 weeks removing the below elbow cast holder, 6 days intervals of every medication expose 1 day, and be 16 weeks total course for the treatment of.
1.2.2 observation index and evaluation methodology: 16 week checks after treatment, measure respectively the 30g pressure sensation, 2g sense of touch, the 5g pain sensation of skin in injured nerve domination zone and at 2 and differentiate and feel that patient's number of<10 mm and percent and differentiate the numerical value contrast of feeling and make comparison at 2.
2 results.
2.1 in 16 weeks after treatment, differentiate and feel for three groups of pressure sensations, sense of touch, the pain sensation and 2 > patient of 10mm compares, and the results are shown in following table:
| Group | Number of cases | Pressure sensation (%) | Sense of touch | The pain sensation | Differentiate for 2 and feel |
| Matched group | 24 | 70.83% | 70.83% | 41.67% | 20.83% |
| Dress group | 22 | 100% | 100% | 72.73% | 50% |
| The unguentum group | 23 | 100% | 100% | 82.61% | 69.57% |
Display application the present invention as a result dresses or the patient of unguentum external application differentiates recovery feel aspect apparently higher than blank group (P<0.05) the pain sensation and at 2.
2.2 three groups of adverse reactions of patients incidence rates relatively: three groups any obvious adverse reaction record all do not occur, dress group and unguentum group local skin and obvious red and swollen pruritus do not occur, the equal omnidistance completed treatment of all cases.
3. conclusion.
This result of study shows, the present invention dresses or the unguentum external application can accelerate to repair the nervous tissue after damage, improves nervous tissue and transmits and dysbolismus.And follow up a case by regular visits to and do not find in the medication process to occur any untoward reaction, illustrate that this externally-applied medicinal composition clinical practice is safe.
Claims (2)
1. the externally-applied medicinal composition for rehabilitation after common peroneal nerve injury, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Solani Lyratis, 6 ~ 12 parts of Pseudobulbus Cremastrae Seu Pleioness, 3 ~ 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 6 ~ 12 parts of Herba Spilanthis Acmellae, 3 ~ 10 parts of Cacumen Securinegae Suffruticosaes, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Fructus Ligustri Lucidi, 6 ~ 12 parts of Fructus Aurantii Immaturuss, 6 ~ 12 parts of Folium Cassiae Alataes, 1 ~ 5 part of HUOXUEDAN, 10 ~ 25 parts of 3 ~ 10 parts, nine layers wind of Folium Salicis Babylonicae moss.
2. a kind of externally-applied medicinal composition for rehabilitation after common peroneal nerve injury according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Herba Solani Lyratis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 6 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10 parts of Herba Spilanthis Acmellae, 6 parts of Cacumen Securinegae Suffruticosaes, 10 parts of Fructus Mori, 10 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Aurantii Immaturuss, 10 parts of Folium Cassiae Alataes, 2 parts of HUOXUEDAN, 20 parts of 6 parts, nine layers wind of Folium Salicis Babylonicae moss.
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Cited By (1)
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| CN105214045A (en) * | 2015-10-27 | 2016-01-06 | 刘小民 | The preparation method of external used medicine and medicine composition after a kind of nerve injury |
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