CN105214045A - The preparation method of external used medicine and medicine composition after a kind of nerve injury - Google Patents
The preparation method of external used medicine and medicine composition after a kind of nerve injury Download PDFInfo
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- CN105214045A CN105214045A CN201510716463.2A CN201510716463A CN105214045A CN 105214045 A CN105214045 A CN 105214045A CN 201510716463 A CN201510716463 A CN 201510716463A CN 105214045 A CN105214045 A CN 105214045A
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Abstract
The invention discloses preparation method and the medicine composition of external used medicine after a kind of nerve injury, get Herba Solani Lyrati 10-30 part, Fructus Ligustri Lucidi 6-12 part, Folium Cassiae Alatae 6-12 part, Fructus Viburni Foetidi leaf 1-5 part, Folium Salicis Babylonicae moss 3-9 part, nine layers of wind 15-25 part, Caulis Erycibes 6-12 part, Cacumen Securinegae Suffruticosae 2-10 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-10 part, Herba Spilanthis Acmellae 6-12 part, HUOXUEDAN 1-5 part, Rhizoma Zingiberis Recens 2-10 part, Radix Puerariae 1-5 part, Herba Menthae 1-9 part, Fructus Forsythiae 5-15 part, Poria 3-9 part, Fructus Schisandrae Chinensis 3-9 part mixing and water adding decocts, filtrate is gone after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, concentrate drying dresses after pulverizing.The present invention has unique logical stagnant effect, the maintenance of the growth promoter of nerve fiber, axon regeneration and synaptic function can be promoted, grow again neural or can determine to grow along correct direction with inducing neural projection in regeneration, normal neural axon can not be made to sprout, also there is the multi-efficiencies such as pain relieving dissipating blood stasis, promoting blood circulation to remove obstruction in the collateral, contribute to the treatment after nerve injury and recovery.
Description
Technical field
The present invention relates to drug world, specifically the preparation method of external used medicine and medicine composition after a kind of nerve injury.
Background technology
Common peroneal nerve (nervusperoneuscommunis) the neck of fibula place location tables that detours is shallow, and be close to periosteum, therefore fracture of fibular neck or use fixation device can not be involved at that time, shank extensor is caused to paralyse and cause drop foot, there is dorsiflexion of foot, dysfunction of turning up, in varus apron deformity.And stretch thumb, stretch apodization function and lose, in flexion, and before anterolateral crural and instep, inner side sensory disturbance.Reparation after common peroneal nerve injury is one of the difficult problem in Neurology Department field.The essence of neuranagenesis is that injured neurons forms new aixs cylinder, can rebuild synaptic contact, and recover normal function with target organ.Wherein any one link goes wrong, and all will affect the functional rehabilitation after common peroneal nerve injury.
The common peroneal nerve injury medicine of current Clinical practice has exogenous neurotrophic factor, adenylic acid Cycloxygenase activator and cyclic adenosine monophosphate, Protein kinase C, inflammatory factor, vitamin B complex etc.Nerve growth factor (nervegrowthfactor in its exogenous neurotrophic factor, NGF) curative effect is the most reliable, but also there is side effect in application NGF: sprouting of int normal neuronal aixs cylinder, can cause the untoward reaction such as chronic pain and abnormal neuron reflection to occur.Therefore exploration one class of still needing at present can promote neural growth fast, can ensure again the inexpensive drugs of regenerated nervous fibers function.Chinese medicine after common peroneal nerve injury is the based uplink gas promoting blood circulation to remove obstruction in the collateral being vigorate qi and replenish the blood then more, but actual clinical effect not obvious.Acupuncture effect is obviously better than Chinese medicine, but patient is difficult to adhere to.
Summary of the invention
The object of the present invention is to provide preparation method and the medicine composition of external used medicine after a kind of nerve injury, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
The preparation method of external used medicine after a kind of nerve injury, get Herba Solani Lyrati 10-30 part, Fructus Ligustri Lucidi 6-12 part, Folium Cassiae Alatae 6-12 part, Fructus Viburni Foetidi leaf 1-5 part, Folium Salicis Babylonicae moss 3-9 part, nine layers of wind 15-25 part, Caulis Erycibes 6-12 part, Cacumen Securinegae Suffruticosae 2-10 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-10 part, Herba Spilanthis Acmellae 6-12 part, HUOXUEDAN 1-5 part, Rhizoma Zingiberis Recens 2-10 part, Radix Puerariae 1-5 part, Herba Menthae 1-9 part, Fructus Forsythiae 5-15 part, Poria 3-9 part, Fructus Schisandrae Chinensis 3-9 part mixing and water adding decocts, filtrate is gone after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, concentrate drying dresses after pulverizing.
External used medicine after a kind of nerve injury, it is made up of the medical material of following weight portion, Herba Solani Lyrati 15-25 part, Fructus Ligustri Lucidi 8-10 part, Folium Cassiae Alatae 8-10 part, Fructus Viburni Foetidi leaf 2-4 part, Folium Salicis Babylonicae moss 5-7 part, nine layers of wind 17-23 part, Caulis Erycibes 7-11 part, Cacumen Securinegae Suffruticosae 4-8 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4-8 part, Herba Spilanthis Acmellae 8-10 part, HUOXUEDAN 2-4 part, Rhizoma Zingiberis Recens 3-9 part, Radix Puerariae 2-4 part, Herba Menthae 3-7 part, Fructus Forsythiae 7-13 part, Poria 4-8 part, Fructus Schisandrae Chinensis 4-8 part.
As the present invention's further scheme: external used medicine after described nerve injury, it is made up of the medical material of following weight portion, Herba Solani Lyrati 20 parts, Fructus Ligustri Lucidi 9 parts, Folium Cassiae Alatae 9 parts, 3 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts, Caulis Erycibes 9 parts, Cacumen Securinegae Suffruticosae 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts, Herba Spilanthis Acmellae 9 parts, HUOXUEDAN 3 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Puerariae 3 parts, Herba Menthae 5 parts, Fructus Forsythiae 10 parts, 6 parts, Poria, Fructus Schisandrae Chinensis 6 parts.
Wherein said:
Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati SolanumlyratumThunb..Sweet in the mouth, hardship, cold in nature.Return liver, gallbladder, kidney channel.Merit can clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), is Araliaceae Schefflera plant schefflera arboricola SchefflevaarboricolaHayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (WightetArn.) Harms, is used as medicine with stem and leaf.Nature and flavor are bitter, sweet, temperature.Merit can pain relieving dissipating blood stasis, detumescence.
Cacumen Securinegae Suffruticosae is browse or the root of euphorbia plant Suffrutescent Securinega Twig Securinegasuffruticosa (Pall.) Rehd..Acrid in the mouth, hardship; Slightly warm in nature.Return liver; Kidney; Spleen channel.Merit can expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi LigustrumlucidumAit..Nature and flavor sweet, bitter, cold.Return liver, kidney channel.Merit can nourishing the liver and kidney, improving eyesight black hair.
Folium Cassiae Alatae, is pulse family Folium Cassiae Alatae CassiaalataL., is used as medicine with leaf.Nature and flavor are pungent, temperature.Merit can parasite killing, antipruritic.
HUOXUEDAN is labiate HUOXUEDAN G.HederaceaL.var.longitubaNakai; G.hederaceaauct.nonL. herb.Bitter in the mouth; Pungent; Cool in nature.Return liver; Gallbladder; Wing skin warp.Merit can dampness removing treating stranguria; Heat-clearing and toxic substances removing; Loose addiction detumescence.
Folium Salicis Babylonicae moss is the plant of Amblystegiaceae Folium Salicis Babylonicae moss Amblystegiumserpens (Hedw.) B.S.G..Nature and flavor are puckery; Flat.Merit can astringing to arrest bleeding.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus SpatholobussuberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.
Fructus Viburni Foetidi leaf is the leaf of Radix Ophiopogonis place plant pod lotus ViburnumfoetidrmWall..Puckery; Property is put down.Merit can be detoxified; Symplectic bone.
Compared with prior art, the present invention has unique logical stagnant effect, the maintenance of the growth of nerve fiber, growth, axon regeneration and synaptic function can be promoted, grow again neural or can determine to grow along correct direction with inducing neural projection in regeneration, normal neural axon can not be made to sprout, meanwhile, also there is the multi-efficiencies such as pain relieving dissipating blood stasis, promoting blood circulation to remove obstruction in the collateral, contribute to the treatment after nerve injury and recovery.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
Raw material weight proportioning: Herba Solani Lyrati 20 parts, Fructus Ligustri Lucidi 9 parts, Folium Cassiae Alatae 9 parts, 3 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts, Caulis Erycibes 9 parts, Cacumen Securinegae Suffruticosae 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts, Herba Spilanthis Acmellae 9 parts, HUOXUEDAN 3 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Puerariae 3 parts, Herba Menthae 5 parts, Fructus Forsythiae 10 parts, 6 parts, Poria, Fructus Schisandrae Chinensis 6 parts.
The preparation method of embodiment 1 is: Herba Solani Lyrati, Fructus Ligustri Lucidi, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, nine layers of wind, Caulis Erycibes, Cacumen Securinegae Suffruticosae, the Rhizoma Atractylodis Macrocephalae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Spilanthis Acmellae, HUOXUEDAN, Rhizoma Zingiberis Recens, Radix Puerariae, Herba Menthae, Fructus Forsythiae, Poria, Fructus Schisandrae Chinensis mixing and water adding are decocted, filtrate is gone after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying dresses after pulverizing.
Embodiment 2
Raw material weight proportioning: get Herba Solani Lyrati 10 parts, Fructus Ligustri Lucidi 6 parts, Folium Cassiae Alatae 6 parts, 1 part, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 3 parts, nine layers of wind 15 parts, Caulis Erycibes 6 parts, Cacumen Securinegae Suffruticosae 2 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2 parts, Herba Spilanthis Acmellae 6 parts, HUOXUEDAN 1 part, 2 parts, Rhizoma Zingiberis Recens, Radix Puerariae 1 part, Herba Menthae 1 part, Fructus Forsythiae 5 parts, 3 parts, Poria, Fructus Schisandrae Chinensis 3 parts.
Embodiment 3
Raw material weight proportioning: get Herba Solani Lyrati 30 parts, Fructus Ligustri Lucidi 12 parts, Folium Cassiae Alatae 12 parts, 5 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 9 parts, nine layers of wind 25 parts, Caulis Erycibes 12 parts, Cacumen Securinegae Suffruticosae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 parts, Herba Spilanthis Acmellae 12 parts, HUOXUEDAN 5 parts, 10 parts, Rhizoma Zingiberis Recens, Radix Puerariae 5 parts, Herba Menthae 9 parts, Fructus Forsythiae 15 parts, 9 parts, Poria, Fructus Schisandrae Chinensis 9 parts.
Embodiment 4
Raw material weight proportioning: Herba Solani Lyrati 20 parts, Fructus Ligustri Lucidi 9 parts, Folium Cassiae Alatae 9 parts, 3 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts, Caulis Erycibes 9 parts, Cacumen Securinegae Suffruticosae 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts, Herba Spilanthis Acmellae 9 parts, HUOXUEDAN 3 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Puerariae 3 parts, Herba Menthae 5 parts, Fructus Forsythiae 10 parts, 6 parts, Poria, Fructus Schisandrae Chinensis 6 parts.
The Chinese medicine of embodiment 2-4 can be prepared from by following method:
(1) Fructus Ligustri Lucidi, Cacumen Securinegae Suffruticosae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) HUOXUEDAN, Folium Salicis Babylonicae moss are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Herba Solani Lyrati, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, nine layers of wind, Caulis Erycibes, the Rhizoma Atractylodis Macrocephalae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Spilanthis Acmellae, Rhizoma Zingiberis Recens, Radix Puerariae, Herba Menthae, Fructus Forsythiae, Poria, Fructus Schisandrae Chinensis are decocted with water 2 times, filter, merging filtrate, is concentrated into relative density 1.1, obtains Aqueous extracts;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the Aqueous extracts of step 3 gained, stir, be concentrated into relative density 1.36.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
The efficient combination of said medicine, coordinates mutually, invigorates blood circulation, eliminates the phlegm, dredging collateral, effectively reach the object promoting CO2 laser weld after common peroneal nerve injury treatment, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
Case selection: the compressing that in June ,-2013 in January, 2012 accepts for medical treatment or soft tissue contusion cause common peroneal nerve injury 69 example, and common peroneal nerve crack conditions does not all appear in all patients.Wherein male 40 example, women 29 example, age 20-63 year, 28.5 years old mean age.
Grouping: be divided into matched group 24 example at random, dress group 22 example, unguentum group 23 is routine, compare in sex, age, the state of an illness before three groups of patient treatments, no significant difference (P > 0.05), has comparability.
Administering mode: matched group takes conventional therapy and function to rebuild, if desired row plaster slab fix, dress group adopts embodiment 1 gained medicament local to dress on the basis of matched group, unguentum group adopts embodiment 4 gained unguentum Local out dressing on the basis of matched group, dress group and unguentum group within every 3 days, change dressings once, after within after treatment 4 weeks, removing below elbow cast holder, every medication 6 days intervals expose 1 day, and total course for the treatment of is 16 weeks.
Observation index and evaluation methodology: check in 16 weeks after treatment, measure the 30g pressure sensation of skin in injured nerve domination region respectively, 2g sense of touch, the 5g pain sensation and 2 differentiate and feel that patient's numbers of < 10mm and percent and differentiate the numerical value of feeling and contrast to make and compare at 2.
Latter 16 weeks for the treatment of, compares three groups of pressure sensations, sense of touch, the pain sensation and 2 patients differentiating feel > 10mm, the results are shown in following table:
| Group | Number of cases | Pressure sensation | Sense of touch | The pain sensation | Differentiate for 2 and feel |
| Matched group | 24 | 70.83％ | 70.83％ | 41.67％ | 20.83％ |
| Dress group | 22 | 100％ | 100％ | 72.73％ | 50％ |
| Unguentum group | 23 | 100％ | 100％ | 82.61％ | 69.57％ |
The present invention of result display application dresses or the patient of unguentum external application differentiates recovery feels in apparently higher than blank group (P < 0.05) the pain sensation and at 2.
Three groups of adverse reactions of patients incidence rates compare: any obvious record of bad behavior does not all appear in three groups of patients, dress group and unguentum group local skin there is not obvious red and swollen pruritus, the equal omnidistance completed treatment of all cases.
This result of study shows, and the present invention dresses or unguentum external application can accelerate the nervous tissue after repairing damage, improves nervous tissue and transmits and dysbolismus.And do not find in following up a case by regular visits to occur any untoward reaction in medication process, illustrate that this externally-applied medicinal composition clinical practice is safe.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, can also makes a variety of changes under the prerequisite not departing from this patent aim.
Claims (3)
1. the preparation method of external used medicine after a nerve injury, it is characterized in that, get Herba Solani Lyrati 10-30 part, Fructus Ligustri Lucidi 6-12 part, Folium Cassiae Alatae 6-12 part, Fructus Viburni Foetidi leaf 1-5 part, Folium Salicis Babylonicae moss 3-9 part, nine layers of wind 15-25 part, Caulis Erycibes 6-12 part, Cacumen Securinegae Suffruticosae 2-10 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-10 part, Herba Spilanthis Acmellae 6-12 part, HUOXUEDAN 1-5 part, Rhizoma Zingiberis Recens 2-10 part, Radix Puerariae 1-5 part, Herba Menthae 1-9 part, Fructus Forsythiae 5-15 part, Poria 3-9 part, Fructus Schisandrae Chinensis 3-9 part mixing and water adding decocts, filtrate is gone after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, concentrate drying dresses after pulverizing.
2. after a nerve injury, the medicine of external used medicine forms, it is characterized in that, it is made up of the medical material of following weight portion, Herba Solani Lyrati 15-25 part, Fructus Ligustri Lucidi 8-10 part, Folium Cassiae Alatae 8-10 part, Fructus Viburni Foetidi leaf 2-4 part, Folium Salicis Babylonicae moss 5-7 part, nine layers of wind 17-23 part, Caulis Erycibes 7-11 part, Cacumen Securinegae Suffruticosae 4-8 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4-8 part, Herba Spilanthis Acmellae 8-10 part, HUOXUEDAN 2-4 part, Rhizoma Zingiberis Recens 3-9 part, Radix Puerariae 2-4 part, Herba Menthae 3-7 part, Fructus Forsythiae 7-13 part, Poria 4-8 part, Fructus Schisandrae Chinensis 4-8 part.
3. after nerve injury according to claim 2, the medicine of external used medicine forms, it is characterized in that, it is made up of the medical material of following weight portion, Herba Solani Lyrati 20 parts, Fructus Ligustri Lucidi 9 parts, Folium Cassiae Alatae 9 parts, 3 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts, Caulis Erycibes 9 parts, Cacumen Securinegae Suffruticosae 6 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts, Herba Spilanthis Acmellae 9 parts, HUOXUEDAN 3 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Puerariae 3 parts, Herba Menthae 5 parts, Fructus Forsythiae 10 parts, 6 parts, Poria, Fructus Schisandrae Chinensis 6 parts.
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Citations (3)
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| CN103393954A (en) * | 2013-08-19 | 2013-11-20 | 刘建贞 | Preparation method of ointment for helping rehabilitation of peroneal nerve injury |
| CN103405649A (en) * | 2013-08-19 | 2013-11-27 | 刘建贞 | External pharmaceutical composition for recovery after nervus peroneus communis injury |
| CN104645052A (en) * | 2013-08-19 | 2015-05-27 | 刘建贞 | Preparation method of external medicine for nerve injury |
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- 2015-10-27 CN CN201510716463.2A patent/CN105214045A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393954A (en) * | 2013-08-19 | 2013-11-20 | 刘建贞 | Preparation method of ointment for helping rehabilitation of peroneal nerve injury |
| CN103405649A (en) * | 2013-08-19 | 2013-11-27 | 刘建贞 | External pharmaceutical composition for recovery after nervus peroneus communis injury |
| CN104645052A (en) * | 2013-08-19 | 2015-05-27 | 刘建贞 | Preparation method of external medicine for nerve injury |
Non-Patent Citations (2)
| Title |
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| 韩卢丽 等: "补阳还五汤治疗下肢神经损伤56例", 《四川中医》 * |
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