CN109200150A - 一种治疗前列腺癌的药物及其制备方法 - Google Patents
一种治疗前列腺癌的药物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗前列腺癌的药物及其制备方法,所述治疗前列腺癌的药物包括如下原料:皂角刺、益母草、紫石英、金银花、丹参、王不留行、仙茅、仙灵脾、蛇床子、覆盆子、金樱子、车前子、生大黄、板蓝根、山豆根、牛膝、川芎、甲珠、硝石、通草、五味子、肉桂、川厚朴、甘草、水蛭、
Description
技术领域
本发明属中药领域,具体涉及一种治疗前列腺癌的药物及其制备方法。
背景技术
传统中医认为,癌瘤常呈慢肿渐趋,无急痛的症状,且病因病机突出,病理性质严峻,应归属于阴疽范畴。因而,需采用传统医学汗、吐、下、和、温、补、清、消八大治疗法则中的温、补、清、消四大治法,并且须要四法并举,综合进行治疗,才能保障应症对法而奏特效。
其中,温是指温化、温散癌瘤,水寒则冰、则凝,水热则沸、则化。癌瘤亦然,须用壮热之药才能温散化解;此补是指补充元气,强其根本,实现扶正驱邪,添助药力的目的;此清是指将体内被温散化解的癌细胞清除出体外;此消即消通道路,使药有进路,邪有去路。只有如此,才是治疗癌症的真正有效之法。
前列腺癌多因前列腺炎、前列腺增生等疾病失治变性而致。而前列腺炎、前列腺增生等疾病青少年罕见,中老年频发。由此可知,其病因多属肾元虚损、司为无力导致气滞血瘀、湿热交阻及水道不通而患。治疗的关键便是补虚强肾治其本,解毒化瘀治其标,双管齐下,标本同治。
公开号为CN108339041A的专利提出一种用于治疗前列腺癌的中药,由如下重量份的原料组成:喜树果7份、益母草8份、黄连3份、昆布8份、粉萆薢10份、地枫皮7份、荔枝核6份、鸭跖草11份和蓍草1份,所述中药总有效率达84%,且未见副作用,安全有效。但受限于组分数量,仍有进一步研发的空间。
发明内容
为了解决现有技术存在的问题,本发明提供了一种治疗前列腺癌的药物及其制备方法。所述治疗前列腺癌的药物通过原料的科学组合,达到标本兼治,有良好的治愈效果。所述制备方法简单易操作,且可将药物制备成小蜜丸或浓缩膏,大大拓宽了受众人群。
本发明的方案为,提供一种治疗前列腺癌的药物,包括如下重量份的原料:皂角刺24~36份、益母草24~36份、紫石英24~36份、金银花24~36份、丹参12~18份、王不留行12~18份、仙茅12~18份、仙灵脾12~18份、蛇床子12~18份、覆盆子12~18份、金樱子12~18份、车前子12~18份、生大黄12~18份、板蓝根12~18份、山豆根12~18份、牛膝12~18份、川芎8~12份、甲珠8~12份、硝石8~12份、通草8~12份、五味子8~12份、肉桂8~12份、川厚朴8~12份、甘草8~12份、水蛭7~11份、虫7~11份、虻虫4~8份和蜈蚣2~4份。
优选地,所述治疗前列腺癌的药物,包括如下重量份的原料:皂角刺30份、益母草30份、紫石英30份、金银花30份、丹参15份、王不留行15份、仙茅15份、仙灵脾15份、蛇床子15份、覆盆子15份、金樱子15份、车前子15份、生大黄15份、板蓝根15份、山豆根15份、牛膝15份、川芎10份、甲珠10份、硝石10份、通草10份、五味子10份、肉桂10份、川厚朴10份、甘草10份、水蛭9份、虫9份、虻虫6份和蜈蚣3份。
本发明还提供一种所述治疗前列腺癌的药物的制备方法,包括以下步骤:
(1)将各原料混合后,加入白酒炙制,得原料混合物;
(2)将步骤(1)所述原料混合物进行纳米粉碎,得到粉碎后原料;将所述粉碎后原料与蜂蜜均匀混合,即得治疗前列腺癌的药物。
再将上述治疗前列腺癌的药物制成0.2~0.3g/丸的小蜜丸,装瓶即可。
本发明还提供一种所述治疗前列腺癌的药物的服用方法:成人每日2次,早晚空腹时服用,每次9~12g,服用60~90min后再进食;儿童用量减半。另外,病情严重者可酌情增量服用。
优选地,步骤(1)中,所述各原料总量与白酒的重量比为1:0.1~0.12,所述白酒的酒精度为42~52%vol。
优选地,步骤(1)中,所述炙制的方法为:将白酒等量分2~3次加入原料中进行翻炒,每次翻炒时间3~5min。
优选地,步骤(2)中,所述粉碎后原料的粒度为300~500nm。
优选地,步骤(2)中,所述粉碎后原料与蜂蜜的重量比为1:0.15~0.20;所述蜂蜜为油菜花蜂蜜。
本发明再提供一种所述治疗前列腺癌的药物的制备方法,包括以下步骤:
(i)将各原料与水混合后浸泡,再进行煎煮,过滤后得药汁;
(ii)将药汁进一步浓缩成膏,即得治疗前列腺癌的药物。
优选地,步骤(i)中,所述各原料总量与水的重量比为1:2~4;所述浸泡用水的温度为30~45℃,所述浸泡时间为2~3h;所述煎煮方法为:先以武火煎煮5~10min,再转文火煎煮90~120min。
优选地,步骤(ii)中,所述浓缩温度为50~60℃;所述浓缩至原体积的1/4~1/3。
相应的,本发明再提供一种所述治疗前列腺癌的药物的服用方法:成人每日2次,早晚空腹时服用,每次120~150ml,服用60~90min后再进食;儿童用量减半。另外,病情严重者可酌情增量服用。
服用药物期间有如下注意事项:
(1)服用期间不可有性生活;(2)服用需连续,不可间断;(3)禁食白糖、葱、姜、蒜等辛辣食物及白萝卜、绿豆等反药性的食物。
本发明的有益效果为:
1、本发明所述的治疗前列腺癌的药物,以仙茅、仙灵脾、蛇床子、覆盆子、金樱子、五味子、车前子、紫石英和肉桂补虚强肾,先治其本;以金银花、板蓝根、山豆根、虻虫、蜈蚣、水蛭和虫解毒化瘀,再治其标;以丹参、川芎、甲珠、硝石、皂角刺、王不留行、益母草、通草、川厚朴和生大黄通关祛瘀,攻坚散积;以牛膝引药下行;以甘草解毒,调和诸药,共奏治疗前列腺癌。综上可得,原料组分标本兼治,缺一不可,作用相互协同,对前列腺癌有良好的治愈效果。
2、本发明所述的治疗前列腺癌的药物的制备方法,可通过不同的工艺将原料制备成小蜜丸或浓缩膏,大大拓展了受众人群。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(1)将240g皂角刺、360g益母草、240g紫石英、360g金银花、120g丹参、180g王不留行、120g仙茅、180g仙灵脾、120g蛇床子、180g覆盆子、120g金樱子、180g车前子、120g生大黄、180g板蓝根、120g山豆根、180g牛膝、80g川芎、120g甲珠、80g硝石、120g通草、80g五味子、120g肉桂、80g川厚朴、120g甘草、70g水蛭、110g虫、40g虻虫和40g蜈蚣混合后,分2次等量加入203g浓度为52%vol的白酒进行翻炒,每次翻炒时间为3min,完毕后,得原料混合物;
(2)将步骤(1)所述原料混合物粉碎至粒度为300~350nm,得到粉碎后原料,将所述粉碎后原料与油菜花蜂蜜均匀混合,所述粉碎后原料与油菜花蜂蜜的重量比为1:0.15,并制成0.2~0.3g/丸的小蜜丸,即得治疗前列腺癌的药物。
实施例2
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(1)将360g皂角刺、240g益母草、360g紫石英、240g金银花、180g丹参、120g王不留行、180g仙茅、120g仙灵脾、180g蛇床子、120g覆盆子、180g金樱子、120g车前子、180g生大黄、120g板蓝根、180g山豆根、120g牛膝、120g川芎、80g甲珠、120g硝石、80g通草、120g五味子、80g肉桂、120g川厚朴、80g甘草、110g水蛭、70g虫、80g虻虫和20g蜈蚣混合后,分3次等量加入163g浓度为42%vol的白酒进行翻炒,每次翻炒时间为5min,完毕后,得原料混合物;
(2)将步骤(1)所述原料混合物粉碎至粒度为450~500nm,得到粉碎后原料,将所述粉碎后原料与油菜花蜂蜜均匀混合,所述粉碎后原料与油菜花蜂蜜的重量比为1:0.2,并制成0.2~0.3g/丸的小蜜丸,即得治疗前列腺癌的药物。
实施例3
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(1)将300g皂角刺、300g益母草、300g紫石英、300g金银花、150g丹参、150g王不留行、150g仙茅、150g仙灵脾、150g蛇床子、150g覆盆子、150g金樱子、150g车前子、150g生大黄、150g板蓝根、150g山豆根、150g牛膝、100g川芎、100g甲珠、100g硝石、100g通草、100g五味子、100g肉桂、100g川厚朴、100g甘草、90g水蛭、90g虫、60g虻虫和30g蜈蚣混合后,分2次等量加入204g浓度为52%vol的白酒进行翻炒,每次翻炒时间4min,完毕后,得原料混合物;
(2)将步骤(1)所述原料混合物粉碎至粒度为350~450nm,得到粉碎后原料,将所述粉碎后原料与油菜花蜂蜜均匀混合,所述粉碎后原料与油菜花蜂蜜的重量比为1:0.17,并制成0.2~0.3g/丸的小蜜丸,即得治疗前列腺癌的药物。
实施例4
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(i)将240g皂角刺、360g益母草、240g紫石英、360g金银花、120g丹参、180g王不留行、120g仙茅、180g仙灵脾、120g蛇床子、180g覆盆子、120g金樱子、180g车前子、120g生大黄、180g板蓝根、120g山豆根、180g牛膝、80g川芎、120g甲珠、80g硝石、120g通草、80g五味子、120g肉桂、80g川厚朴、120g甘草、70g水蛭、110g虫、40g虻虫和40g蜈蚣与8120g温度为30℃的水混合浸泡3h,完毕后再以武火煎煮5min,后转文火继续煎煮120min,过滤后得药汁;
(ii)将步骤(i)所得的药汁在50℃条件下浓缩至原体积的1/4,即得治疗前列腺癌的药物。
实施例5
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(i)将360g皂角刺、240g益母草、360g紫石英、240g金银花、180g丹参、120g王不留行、180g仙茅、120g仙灵脾、180g蛇床子、120g覆盆子、180g金樱子、120g车前子、180g生大黄、120g板蓝根、180g山豆根、120g牛膝、120g川芎、80g甲珠、120g硝石、80g通草、120g五味子、80g肉桂、120g川厚朴、80g甘草、110g水蛭、70g虫、80g虻虫和20g蜈蚣与16320g温度为45℃的水混合浸泡2h,完毕后再以武火煎煮10min,后转文火继续煎煮90min,过滤后得药汁;
(ii)将步骤(i)所得的药汁在60℃条件下浓缩至原体积的1/3,即得治疗前列腺癌的药物。
实施例6
本实施例提供一种治疗前列腺癌的药物的制备方法,包括如下步骤:
(i)将300g皂角刺、300g益母草、300g紫石英、300g金银花、150g丹参、150g王不留行、150g仙茅、150g仙灵脾、150g蛇床子、150g覆盆子、150g金樱子、150g车前子、150g生大黄、150g板蓝根、150g山豆根、150g牛膝、100g川芎、100g甲珠、100g硝石、100g通草、100g五味子、100g肉桂、100g川厚朴、100g甘草、90g水蛭、90g虫、60g虻虫和30g蜈蚣与12210g温度为38℃的水混合浸泡2.5h,完毕后再以武火煎煮8min,后转文火继续煎煮105min,过滤后得药汁;
(ii)将步骤(i)所得的药汁在55℃条件下浓缩至原体积的1/3,即得治疗前列腺癌的药物。
在2008~2018年之间,发明人接诊治疗前列腺癌患者151人,其中有效108人:有效者中显效94人;显效者中临床治愈85人。由此可得,有效率为71.5%;显效率为62.3%,治愈率为56.3%。
其中,有效标准为:比较治疗之前或前期所进行的治疗情况,自我感觉症状有所缓解,生存质量有所改善;显效标准为:比较同类患者,临床表现病理周期拉长,生存质量明显改善,生命延长一年以上;临床治愈标准为:各样体检指标基本正常,生命期5年以上。
现选取如下典型案例,用以说明所述治疗前列腺癌的药物的效果。
案例1:
徐某,男,61岁,唐山人;徐先生尿频、尿急、尿痛、尿线分叉、小腹时儿胀痛、伴腰膝酸软、头昏、口渴、大便干结。初时于社区医院做前列腺增生治疗2个月,症状加重,入上级医院治疗,完善各项检查,诊断为前列腺癌。10次放疗,3次化疗,症状未缓解,身体反而更差。发明人进行后续诊断,诊见为:体虚弱、面暗淡、目无光华、舌暗红、苔黄厚及脉沉弦。徐先生服用本发明所述治疗前列腺癌的药物,先服用浓缩膏16d,每天4次,分别于6点、11点、18点,23点各服1次,每次130ml,患者自诉大便不再干结,尿频,尿急,尿痛症状好转;照法续服32d,症状进一步好转,大便顺畅,小便无潴留,少愎按压无疼痛;改服小蜜丸62d,每日3次,每次9g,分别于3餐前90min温开水送服。120天后复查,各项指数均接近正常。
案例2:
谭某,男,68岁,沧州人;谭先生排尿困难2年余,肛诊前列腺III肿大,中间沟消失,质硬。经氟哌酸、乙烯雌酚治疗1周后仍无好转,怀疑癌变,抽样检查证实为前列腺癌,前后共经7次放疗和4次化疗。发明人进行后续诊断,诊见为:精神萎顿、面色晦滞、舌质暗紫、苔薄白及脉弦细涩。谭先生服用本发明所述治疗前列腺癌的药物,先服用浓缩膏24d,每天4次,分别于6点、11点、18点,23点各服1次,每次130ml,患者自诉大便不再干结,少腹硬满渐变松软;照法续服40d,症状进一步好转,大便顺畅,少愎按压无疼痛;再后改服小蜜丸72d,每日3次,每次9g,分别于3餐前90min温开水送服。经复查后,各项指数明显好转,无转移扩散。
案例3:
肖某,男,82岁,廊坊人;病历记载:肖先生反复排尿不畅、滴沥不尽9年,加重1周;直肠指诊前列腺大如鸡卵,中间沟消失;B超显示前列腺4.9cm×5.2cm,残余尿量>70m1。进一步完全检查结论为前列腺肿大恶性改变,考虑年事已高,寻求中医保守治疗。发明人进行后续诊断,诊见为:舌暗红、苔薄白、脉细涩,由于尿潴留已上导尿管。肖先生服用本发明所述治疗前列腺癌的药物,先服用浓缩膏24d,每天4次,分别于6点、11点、18点,23点各服1次,每次130ml,患者自诉大便不再干结,少腹硬满渐变松软;照法续服40d,症状进一步好转,大便顺畅,少愎按压无疼痛;再后改服小蜜丸72d,每日3次,每次9g,分别于3餐前90min温开水送服。经复查后,各项指数明显好转,无转移扩散。
案例4:
杨某,男,75岁,张家口人;杨先生患前列腺增生10年,屡治屡次复发,6个月前加重,直肠指诊前列腺Ⅲ级肿大,中间沟消失,质硬,完善各项检查结论为:前列腺肿大癌变。后由发明人进行诊断,诊见为:舌质黯淡、舌边明显瘀斑、苔薄白及脉沉迟而涩。杨先生服用本发明所述治疗前列腺癌的药物,先服用浓缩膏64d,每天4次,分别于6点、11点、18点,23点各服1次,每次130ml,患者自诉大便顺畅,少愎按压无疼痛;再后改服小蜜丸72d,每日3次,每次9g,分别于3餐前90min温开水送服。经复查后,前列腺癌肿部位缩小为I级,相关指数不正常范围缩小。
案例5:
田某,男,62岁;病历记录患前列腺癌术后化疗4次,疗效不佳,后续经发明人治疗诊见:精神不振、头发脱落、面黄如蜡、舌体瘦而紫、苔黄中带绿及脉浮细而滑。田先生服用本发明所述治疗前列腺癌的药物,先服用浓缩膏64d,每天4次,分别于6点、11点、18点,23点各服1次,每次130ml,患者自诉症状逐渐好转,食胃好转明显,每餐能吃汤食接近常量,精气神明显增强,体重增加8公斤,大便顺畅;再后改服小蜜丸72d,每日3次,每次9g,分别于3餐前90min温开水送服。经复查后,相关指数不正常值范围均有缩小。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗前列腺癌的药物,其特征在于,包括如下重量份的原料:皂角刺24~36份、益母草24~36份、紫石英24~36份、金银花24~36份、丹参12~18份、王不留行12~18份、仙茅12~18份、仙灵脾12~18份、蛇床子12~18份、覆盆子12~18份、金樱子12~18份、车前子12~18份、生大黄12~18份、板蓝根12~18份、山豆根12~18份、牛膝12~18份、川芎8~12份、甲珠8~12份、硝石8~12份、通草8~12份、五味子8~12份、肉桂8~12份、川厚朴8~12份、甘草8~12份、水蛭7~11份、虫7~11份、虻虫4~8份和蜈蚣2~4份。
2.根据权利要求1所述的治疗前列腺癌的药物,其特征在于,包括如下重量份的原料:皂角刺30份、益母草30份、紫石英30份、金银花30份、丹参15份、王不留行15份、仙茅15份、仙灵脾15份、蛇床子15份、覆盆子15份、金樱子15份、车前子15份、生大黄15份、板蓝根15份、山豆根15份、牛膝15份、川芎10份、甲珠10份、硝石10份、通草10份、五味子10份、肉桂10份、川厚朴10份、甘草10份、水蛭9份、虫9份、虻虫6份和蜈蚣3份。
3.权利要求1或2所述的治疗前列腺癌的药物的制备方法,其特征在于,包括以下步骤:
(1)将各原料混合后,加入白酒炙制,得原料混合物;
(2)将步骤(1)所述原料混合物进行纳米粉碎,得到粉碎后原料;将所述粉碎后原料与蜂蜜均匀混合,即得治疗前列腺癌的药物。
4.根据权利要求3所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(1)中,所述各原料总量与白酒的重量比为1:0.1~0.12,所述白酒的酒精度为42~52%vol。
5.根据权利要求3所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(1)中,所述炙制的方法为:将白酒等量分2~3次加入原料中进行翻炒,每次翻炒时间3~5min。
6.根据权利要求3所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(2)中,所述粉碎后原料的粒度为300~500nm。
7.根据权利要求3所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(2)中,所述粉碎后原料与蜂蜜的重量比为1:0.15~0.20;所述蜂蜜为油菜花蜂蜜。
8.权利要求1或2所述的治疗前列腺癌的药物的制备方法,其特征在于,包括以下步骤:
(i)将各原料与水混合后浸泡,再进行煎煮,过滤后得药汁;
(ii)将药汁进一步浓缩成膏,即得治疗前列腺癌的药物。
9.根据权利要求8所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(i)中,所述各原料总量与水的重量比为1:2~4;所述浸泡用水的温度为30~45℃,所述浸泡时间为2~3h;所述煎煮方法为:先以武火煎煮5~10min,再转文火煎煮90~120min。
10.根据权利要求8所述的治疗前列腺癌的药物的制备方法,其特征在于,步骤(ii)中,所述浓缩温度为50~60℃;所述浓缩至原体积的1/4~1/3。
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